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Wenlafaksyna XR, zastosowanie kliniczne większych dawek (> 150 mg) 文拉法辛XR,高剂量临床应用(>150 mg)
Q4 Medicine Pub Date : 2020-05-30 DOI: 10.5603/psych.2020.0014
Paweł Mierzejewski
This paper discusses the dual serotonergic-noradrenergic mechanism of action of venlafaxine, its indications for use, and dosage. Special attention was paid to the clinical application of higher doses of the drug, above 150 mg in the treatment of depression and anxiety disorders. Venlafaxine is one of the most effective antidepressants. The maximum recommended dose is 225 mg/day for anxiety disorders and 375 mg/day for major depression. The use of higher doses of the drug allows to take full advantage of its dual mechanism of action and improve its effectiveness.
本文讨论了文拉法辛的5 -羟色胺能-去甲肾上腺素能双重作用机制、使用适应症和剂量。特别注意高剂量药物的临床应用,在治疗抑郁症和焦虑症中超过150毫克。文拉法辛是最有效的抗抑郁药之一。最大推荐剂量为焦虑症患者每天225毫克,重度抑郁症患者每天375毫克。使用更高剂量的药物可以充分利用其双重作用机制并提高其有效性。
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引用次数: 0
The relationship between personality characteristics and the quality of life in patients with epilepsy 癫痫患者人格特征与生活质量的关系
Q4 Medicine Pub Date : 2020-05-30 DOI: 10.5603/psych.2020.0012
A. Shamsi, Reyhaneh Sadat Tohidi, M. Shamekhi, H. Amirifard, Alireza Ansarimoghadam
Introduction: Identification of effective factors in the quality of life (QOL) of patients with epilepsy is important in improving their quality of life. Regarding this, the present study aimed to investigate the relationship between personality characteristics and QOL in patients with epilepsy. Material and methods: This cross-sectional study was conducted on 100 epileptic patients referred to Neurology Clinic of Ali-ibn Abi Talib Hospital in Zahedan, Iran in 2015. The NEO Personality Inventory (NEO-PI) and Short Form Health Survey (SF-12) questionnaires were used to determine the personality characteristics and QOL scores, respectively. Results: The mean of QOL score was 28.94±4.58. Age, gender, marital status, education level, and duration of epilepsy had no significant correlation with the QOL. The QOL showed a negative correlation with openness to experience and neuroticism. However, this variable had a direct correlation with conscientiousness, agreeableness, and extraversion. There was a significant relationship between the predictor variables (extraversion and neuroticism) and the criterion variable (QOL). Therefore, extraversion and neuroticism can be considered as the predictors of the QOL. Conclusions: The extraversion and neuroticism seem to be two predictors of the QOL in the epileptic patients. Accordingly, whereas the patients with high levels of neuroticism had low QOL, this value was higher in those with high levels of extraversion.
引言:确定影响癫痫患者生活质量(QOL)的因素对提高他们的生活质量很重要。为此,本研究旨在探讨癫痫患者的人格特征与生活质量之间的关系。材料和方法:这项横断面研究是对2015年在伊朗扎黑丹Ali ibn Abi Talib医院神经科门诊就诊的100名癫痫患者进行的。NEO人格问卷(NEO-PI)和短期健康调查(SF-12)分别用于确定人格特征和生活质量分数。结果:生活质量评分平均值为28.94±4.58。年龄、性别、婚姻状况、文化程度和癫痫持续时间与生活质量无显著相关性。生活质量与体验开放性和神经质呈负相关。然而,这个变量与尽责性、宜人性和外向性有直接的相关性。预测变量(外向性和神经质)与标准变量(QOL)之间存在显著关系。因此,外向性和神经质可以被认为是生活质量的预测因素。结论:外向性和神经质似乎是癫痫患者生活质量的两个预测因素。因此,尽管具有高水平神经质的患者的生活质量较低,但在具有高水平外向性的患者中,这一值更高。
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引用次数: 0
Telewizyta (e-wizyta) na czas kryzysu epidemicznego — rekomendacje w zakresie prowadzenia wizyt online w opiece psychiatrycznej
Q4 Medicine Pub Date : 2020-05-30 DOI: 10.5603/psych.2020.0011
Marek Krzystanek, M. Matuszczyk, I. Krupka-Matuszczyk, A. Koźmin-Burzyńska, Seweryn Segiet, J. Przybyło
Telepsychiatry includes the medical services through modern digital media. On-line psychiatric and psychotherapeutic treatment is effective and safe as well as therapeutically equivalent compared to traditional off-line treatment. In times of epidemic crisis and restrictions on outpatient advice, telepsychiatry is an alternative and recommended method. The article presents recommendations on conducting online visits in psychiatric care prepared by the Scientific Section of Telepsychiatry of the Polish Psychiatric Association. The form and subject of conducting tele-visits were discussed, including reactive and somatic factors, and a psychiatric and somatic tele-visit scheme was also proposed.
远程精神病学包括通过现代数字媒体提供的医疗服务。与传统的离线治疗相比,在线精神病学和心理治疗既有效又安全,治疗效果也相当。在流行病危机和门诊咨询限制时期,远程精神病学是一种替代和推荐的方法。这篇文章提出了由波兰精神病学协会远程精神病学科学部门准备的关于在精神病学护理中进行在线访问的建议。讨论了远程访问的形式和主题,包括反应性和躯体性因素,并提出了精神病学和躯体性远程访问方案。
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引用次数: 3
Pacjent z rozpoznaniem organicznych zaburzeń urojeniowych z odczynem depresyjnym — podejście interdyscyplinarne oraz postępowanie w przypadku dodatniego wyniku COVID-19
Q4 Medicine Pub Date : 2020-05-30 DOI: 10.5603/psych.2020.0017
Michał Wroński, Zuzanna Dukaczewska, J. Samochowiec
In this paper we share clinical observations and insights regarding the management and treatment of an uncooperative patient requiring an interdisciplinary approach due to diagnosis of delusional disorder, depressive symptoms, alcohol dependence syndrome, numerous complaints related to concomitant somatic diseases, and coronavirus infection (COVID-19). Our aim was to highlight the significance of a holistic approach to the patient, and scrupulous documentation of existing somatic diseases in psychiatric hospital discharge summary reports. Due to the common lack of compliance on the part of psychiatric patients, it proves utterly important to establish cooperation between healthcare providers and families of the mentally ill. Coronavirus infection (COVID-19) becomes another, additional complication in the management of psychiatric inpatients. We believe that the discussed interdisciplinary approach, together with increased family or institutional supervision can contribute to the improvement of psychiatric patients’ physical and mental health status as well as general functioning.
在本文中,我们分享了关于管理和治疗一位由于诊断妄想障碍、抑郁症状、酒精依赖综合征、伴随躯体疾病的许多投诉和冠状病毒感染(COVID-19)而需要跨学科方法的不合作患者的临床观察和见解。我们的目的是强调对患者采取整体方法的重要性,并在精神病院出院总结报告中仔细记录现有的躯体疾病。由于精神病患者普遍缺乏依从性,因此在医疗保健提供者和精神病患者家属之间建立合作是非常重要的。冠状病毒感染(COVID-19)成为精神科住院患者管理中的另一个并发症。我们相信所讨论的跨学科方法,加上增加家庭或机构的监督,可以有助于改善精神病患者的身心健康状况和一般功能。
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引用次数: 0
„Odkochałem się w sobie” — uraz narcystyczny jako przyczyna pojawienia się objawów depresyjnych u młodych osób “我爱上了自恋型酸奶,这是年轻人出现抑郁症状的原因
Q4 Medicine Pub Date : 2020-05-30 DOI: 10.5603/psych.2020.0018
Sławomir Murawiec
The work presents a case report of a patient with symptoms classified as depression. An in-depth interview revealed a specific problem of this patient, as well as for many other people with similar constellations of psychological processes. On the one hand, high demands addressed to himself, that is expectation of the career level and achievements at worldwide importance. On the other hand, in a situation of confrontation with the requirements of studies and life circumstances, a sense of loss of self-esteem, a sense of lack of future, sense of lost life, self-destructive tendencies and active maintaining of inertness and self-destruction.
该工作提出了一个病例报告的病人的症状分类为抑郁症。一个深入的访谈揭示了这个病人的一个特殊问题,以及许多其他有类似心理过程星座的人的问题。一方面,对自己提出了很高的要求,即期望自己的职业水平和成就具有世界重要性。另一方面,在与学习和生活环境的要求对抗的情况下,出现自尊心的丧失、未来的缺乏、生命的丧失、自我毁灭倾向和主动保持惰性和自我毁灭。
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引用次数: 0
Farmakologiczne leczenie choroby Alzheimera — współczesne możliwości
Q4 Medicine Pub Date : 2020-05-30 DOI: 10.5603/psych.2020.0016
L. Bidzan
Approximately 46 million people worldwide have Alzheimer’s disease (AD). Treatments to prevent or slow down cognitive decline in AD remain an urgent therapeutic need. During the last decades the use of b secretase inhibitors as well as immunotherapy against Ab, antioxidants and anti-inflammatory agents as well as natural products and many others have been investigated. Although considerable efforts have been made to develop more effective therapeutic agents for AD therapy, clinical trials failed to reach efficacy endpoints in improving cognitive function in most cases to date or have been terminated due to adverse events. Current pharmacotherapy of AD is still limited to cholinesterase inhibitors and the N-methyl-D-aspartate antagonist memantine which were approved at the turn of the century. Despite critical opinions on the efficacy of acetylcholinesterase inhibitors and memantine, it should be said that these drugs improve memory and other cognitive functions throughout most of the duration of the disease. As Memantine, and the AChEIs target two different aspects of AD pathology their complementary mechanisms offer superior benefit as combination therapy. Moreover preclinical studies have shown that memantine and AChEIs have neuroprotective effects.
全世界约有4600万人患有阿尔茨海默病(AD)。预防或减缓阿尔茨海默病认知能力下降的治疗仍然是一项迫切的治疗需求。在过去的几十年里,对b分泌酶抑制剂的使用以及针对Ab的免疫疗法、抗氧化剂和抗炎剂以及天然产物和许多其他药物进行了研究。尽管已经做出了相当大的努力来开发更有效的阿尔茨海默病治疗药物,但迄今为止,在大多数病例中,临床试验未能达到改善认知功能的疗效终点,或者由于不良事件而终止。目前阿尔茨海默病的药物治疗仍然局限于胆碱酯酶抑制剂和n -甲基- d -天冬氨酸拮抗剂美金刚,这两种药物是在世纪之交批准的。尽管对乙酰胆碱酯酶抑制剂和美金刚的疗效持批评意见,但应该说这些药物在疾病的大部分时间内都能改善记忆和其他认知功能。Memantine和AChEIs针对AD病理的两个不同方面,它们的互补机制作为联合治疗提供了更好的益处。此外,临床前研究表明,美金刚和乙酰胆酸抑制剂具有神经保护作用。
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引用次数: 1
Arypiprazol w dawce maksymalnej 30 mg i w połączeniu z olanzapiną 最大剂量为30 mg的阿立哌唑与奥氮平联合用药
Q4 Medicine Pub Date : 2020-05-30 DOI: 10.5603/psych.2020.0013
Paweł Mierzejewski
Aripiprazole is an antipsychotic drug with unique pharmacological properties showing ago-antagonistic effects against the D2 receptor and is classified as a III generation antipsychotic. Clinical and preclinical studies indicate efficacy and safety of high doses of aripiprazole in selected patients, supporting the decision to use the drug at a maximum dose of 30 mg/day. This paper presents the mechanism of action of high doses of aripiprazole and discusses clinical situations when it is appropriate to use the drug at the maximum dose. The second part of the study presents arguments for beneficial effects of the combination of aripiprazole with olanzapine and other antipsychotic drugs of II generation.
阿立哌唑是一种具有独特药理特性的抗精神病药物,对D2受体具有ago-拮抗作用,被归类为第三代抗精神病药物。临床和临床前研究表明,在选定的患者中,高剂量阿立哌唑的有效性和安全性,支持最大剂量为30毫克/天的用药决定。本文介绍了大剂量阿立哌唑的作用机理,并讨论了最大剂量用药的临床情况。研究的第二部分提出了阿立哌唑与奥氮平和其他II代抗精神病药物联合使用的有益效果的论点。
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引用次数: 0
Nowe technologie a zdrowie psychiczne — szanse i trudności
Q4 Medicine Pub Date : 2020-03-05 DOI: 10.5603/PSYCH.2020.0007
Ł. Cichocki, M. Karbownik
The article describes the possible consequences of using/abusing new technologies in the context of mental health. It is an attempt to reflect how smartphones, e-mail, computer games, social media affect our lives, things we can do to increase potential benefits and minimize the risks associated with these technologies. Through not only scientific but also personal perspective, the authors try to bring the conclusions from work to life practice.
这篇文章描述了在心理健康方面使用/滥用新技术的可能后果。它试图反映智能手机、电子邮件、电脑游戏、社交媒体如何影响我们的生活,以及我们可以做些什么来增加潜在的好处,并将与这些技术相关的风险降到最低。作者试图通过科学和个人的视角,将工作中的结论运用到生活实践中。
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引用次数: 1
Konsekwencje zachowań agresywnych ze strony pacjentów z zaburzeniami psychicznymi dla personelu medycznego 精神障碍患者攻击行为对医务人员的影响
Q4 Medicine Pub Date : 2020-03-05 DOI: 10.5603/PSYCH.2020.0004
Anna Mosiołek, Jacek Gierus, Mateusz Margański, Katarzyna Margańska, A. Szulc
Wstep: Badanie mialo na celu ocene czestości zachowan agresywnych ze strony pacjentow z zaburzeniami psychicznymi oraz deklarowane sposoby radzenia sobie przez personel medyczny w celu unikniecia konsekwencji agresji. Material i metody: Badanie mialo charakter ankietowy, zostalo przeprowadzone jednorazowo, w 5 miastach w Polsce. Oceniono 102 ankiety wypelnione przez pracownikow medycznych pracujących w placowkach medycznych z pacjentami z zaburzeniami psychicznymi. Ankieta skladala sie z cześci demograficzno-opisowej oraz z 14 pytan dotyczących rodzajow agresji, czestości zachowan agresywnych, sposobow radzenia sobie z agresją oraz rodzaju szkod ponoszonych przez personel. Wyniki: Wiekszośc badanych osob doświadczyla agresji ze strony pacjentow o co najmniej umiarkowanym zasileniu, a u znacznej cześci badanych wskutek tych zdarzen wyksztalcilo sie wypalenie zawodowe lub szkody psychiczne. Glownym sposobem radzenia sobie ze skutkami agresji jest omawianie sytuacji w zespole, nieco rzadziej — stosowanie procedur. Wnioski: Poziom narazenia personelu na agresje nie spotyka sie z wystarczającymi środkami zapobiegawczymi. Autorzy rekomendują wdrazanie w placowkach ochrony zdrowia zarządzania ryzykiem klinicznym.
引言:本研究的目的是评估精神障碍患者攻击性行为的频率,以及医务人员为避免攻击性后果而宣布的应对方式。材料和方法:该调查在波兰的五个城市进行了一次。对在精神障碍患者医疗机构工作的医疗专业人员完成的102项调查进行了评估。该调查包括人口统计和描述性部分,以及14个关于攻击类型、攻击行为频率、如何应对攻击以及员工遭受的伤害类型的问题。结果:大多数受试者经历了来自至少中等供电的患者的攻击,并且很大一部分受试者因这些事件而产生倦怠或精神损伤。处理攻击影响的主要方法是在团队中讨论情况,减少使用程序的频率。结论:没有采取足够的预防措施,使人员暴露在侵略之下。作者建议在医疗机构实施临床风险管理。
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引用次数: 0
Zespół Kasandry
Q4 Medicine Pub Date : 2020-03-05 DOI: 10.5603/psych.2020.0008
Justyna Holka-Pokorska, A. Kucharski
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引用次数: 0
期刊
Psychiatria
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