Pub Date : 2022-06-01DOI: 10.1177/26339447221111606
S. R. Mohammed, S. Teelucksingh, V. Naraynsingh
The Fit India Movement is a nationwide campaign to promote and encourage the incorporation of physical activity and sports into the daily lives of the Indian people. Amongst the objectives is to instill the importance of fitness in students and their families, certainly a most worthy endeavor. Whilst we fully support the promotion of fitness activities among persons of all age groups in India, we would yet like to extend a word of caution regarding barefooted exercising, especially among those persons afflicted with diabetes mellitus. These persons are at greatly increased risk of foot trauma and ulceration. A multidisciplinary approach to caring for diabetes is costly and therefore impractical in low-resource areas. We therefore wish to highlight the “slipping slipper sign”, that is, unrecognized loss of a slipper from a person’s feet while walking, which has been demonstrated to reflect severe peripheral neuropathy. This sign can be elicited by nonmedical staff and is an effective method of identifying high-risk patients who warrant further specialized testing for peripheral neuropathy.
{"title":"Using the Slipping Slipper Sign as a Public Health Message to Protect the Feet of Patients With Diabetes","authors":"S. R. Mohammed, S. Teelucksingh, V. Naraynsingh","doi":"10.1177/26339447221111606","DOIUrl":"https://doi.org/10.1177/26339447221111606","url":null,"abstract":"The Fit India Movement is a nationwide campaign to promote and encourage the incorporation of physical activity and sports into the daily lives of the Indian people. Amongst the objectives is to instill the importance of fitness in students and their families, certainly a most worthy endeavor. Whilst we fully support the promotion of fitness activities among persons of all age groups in India, we would yet like to extend a word of caution regarding barefooted exercising, especially among those persons afflicted with diabetes mellitus. These persons are at greatly increased risk of foot trauma and ulceration. A multidisciplinary approach to caring for diabetes is costly and therefore impractical in low-resource areas. We therefore wish to highlight the “slipping slipper sign”, that is, unrecognized loss of a slipper from a person’s feet while walking, which has been demonstrated to reflect severe peripheral neuropathy. This sign can be elicited by nonmedical staff and is an effective method of identifying high-risk patients who warrant further specialized testing for peripheral neuropathy.","PeriodicalId":40062,"journal":{"name":"Journal, Indian Academy of Clinical Medicine","volume":"31 1","pages":"45 - 46"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75623959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1177/26339447221127080
Arvind Kumar, Tania Bansal, A. Bery, A. Sood
Background: Cardiac structural and functional abnormalities have been described in patients of liver cirrhosis. The constellation of these abnormalities is termed as cirrhotic cardiomyopathy (CCM) and its prevalence remains unknown, mostly because the disease is latent and shows itself when the patient is subjected to stress. This study was designed to evaluate the prevalence of cardiac dysfunction in patients of liver cirrhosis and to analyze its relation with model for end-stage liver disease (MELD) score. Methods: Hundred patients of liver cirrhosis were enrolled for the study and divided into 3 groups according to MELD score: ≤9, 10-19, and ≥20. All study participants underwent detailed cardiac assessment with Doppler echocardiography. Prevalence of cardiac dysfunction and its relation with MELD score was determined. Results: Prevalence of CCM and diastolic dysfunction (DD) was 48% and 30%, respectively. A total of 82%, 59%, and 50% patients had prolonged corrected QT interval (QTc), isovolumic relaxation time (IVRT), and deceleration time (DT), respectively. Prevalence of CCM, DD and prolonged QTc, IVRT, and DT had significant correlation with MELD score (P < .05). Conclusion: Patients with cirrhosis had impaired cardiac function, mainly present as CCM and DD, and the extent of dysfunction was correlated with the MELD score. Hence, MELD scoring system can be used to predict risk of occurrence of cardiac dysfunction in cirrhosis.
{"title":"Prevalence of Cardiac Dysfunction in Cirrhosis and Its Relation With Meld Score","authors":"Arvind Kumar, Tania Bansal, A. Bery, A. Sood","doi":"10.1177/26339447221127080","DOIUrl":"https://doi.org/10.1177/26339447221127080","url":null,"abstract":"Background: Cardiac structural and functional abnormalities have been described in patients of liver cirrhosis. The constellation of these abnormalities is termed as cirrhotic cardiomyopathy (CCM) and its prevalence remains unknown, mostly because the disease is latent and shows itself when the patient is subjected to stress. This study was designed to evaluate the prevalence of cardiac dysfunction in patients of liver cirrhosis and to analyze its relation with model for end-stage liver disease (MELD) score. Methods: Hundred patients of liver cirrhosis were enrolled for the study and divided into 3 groups according to MELD score: ≤9, 10-19, and ≥20. All study participants underwent detailed cardiac assessment with Doppler echocardiography. Prevalence of cardiac dysfunction and its relation with MELD score was determined. Results: Prevalence of CCM and diastolic dysfunction (DD) was 48% and 30%, respectively. A total of 82%, 59%, and 50% patients had prolonged corrected QT interval (QTc), isovolumic relaxation time (IVRT), and deceleration time (DT), respectively. Prevalence of CCM, DD and prolonged QTc, IVRT, and DT had significant correlation with MELD score (P < .05). Conclusion: Patients with cirrhosis had impaired cardiac function, mainly present as CCM and DD, and the extent of dysfunction was correlated with the MELD score. Hence, MELD scoring system can be used to predict risk of occurrence of cardiac dysfunction in cirrhosis.","PeriodicalId":40062,"journal":{"name":"Journal, Indian Academy of Clinical Medicine","volume":"121 1","pages":"6 - 11"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75099852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1177/26339447221127081
R. Mormile
Corresponding author: Raffaella Mormile, Division of Pediatrics and Neonatology, Moscati Hospital, Aversa, Italy, Via A. Gramsci-81031, Italy. E-mail: raffaellamormile@alice.it Aspirin use has been suggested to reduce the risk of hepatocellular carcinoma (HCC).1 It has been reported that aspirin may have beneficial effect as a chemopreventive or adjuvant chemotherapeutic agent in HCC.2 The benefit of aspirin in reducing HCC risk has been proposed to be doserelated and apparent after 5 or more years of use.1 However, it is still unclear whether aspirin administration should be recommended to different populations of patients at risk for HCC.2 According to studies in animal models, it has been hypothesized that the mechanism of cancer preventive action of aspirin against HCC may be related to its antiplatelet and anti-inflammatory activities.2 HCC represents one of the most aggressive malignancies, whose prognosis is extremely poor, mainly due to its high propensity of invasion and metastasis.3 To date, an effective therapeutic approach against invasive or/and metastatic HCC still remains rare.3 Vascular invasion is particularly common in patients with HCC given that liver is an organ rich in blood vessels.3 It has been recognized that microRNA 126 (miR126) exerts a protective role against HCC.3,4,5 microRNAs (miRNAs) have emerged to be linked to human cancer onset and progression having an impact on invasion and metastasis.3 miR-126 belongs to the most abundantly expressed miRNAs in endothelial cells where it is responsible for vascular development.4 Both strands of miR-126: miR-126-3p and miR-126-5p, appear to be biologically active.4 Overexpression of miR-126 in nude mice has been tested to result in reduced weight and less new blood vessels in HCC.6 It has been verified that microRNA-126 (miR-126) is aberrantly downregulated and plays a critical role in carcinogenesis in several cancers, including HCC.5 It has been detected that miR-126 functions as a tumor suppressor in human HCC.5 miR126-3p has been demonstrated to counteract invasion and metastasis in HCC.3 Increasing evidence has revealed that miR-126 is markedly reduced in HCC cell lines and tissues as well as negatively connected with clinic-pathologic parameters.5 Low expression levels of miR-126 have been connected with a poor overall survival, late TNM stage, and the presence of recurrence in HCC.5 Inhibition of miR-126 has been proved to reduce cell apoptosis, and enhanced cell proliferation and tumor angiogenesis.6 Over-expression of miR126 has been shown to significantly reduce cell proliferation metastasis and promote apoptosis in vitro.5 miR-126 represents one of the most copious miRNAs in human platelets.7 miR-126 has been linked to platelet function and reactivity.4 Platelets have been discovered to supply important amounts of miR-126 upon activation into the surrounding plasma in vitro.7 Platelets and platelet microvesicles have been identified to discharge high levels of miR12
通讯作者:Raffaella Mormile，儿科和新生儿科，Moscati医院，avversa, Italy, Via A. Gramsci-81031, Italy。E-mail: raffaellamormile@alice.it阿司匹林已被建议用于降低患肝细胞癌(HCC)的风险据报道，阿司匹林作为HCC的化学预防或辅助化疗药物可能有有益的作用。2阿司匹林在降低HCC风险方面的益处被认为是剂量相关的，并且在使用5年或更长时间后才显现出来然而，目前尚不清楚阿司匹林是否应该推荐给不同人群的HCC高危患者。2根据动物模型的研究，有人假设阿司匹林对HCC的防癌作用机制可能与其抗血小板和抗炎活性有关HCC是最具侵袭性的恶性肿瘤之一，其预后极差，主要是由于其极易侵袭和转移迄今为止，针对侵袭性或/和转移性HCC的有效治疗方法仍然很少鉴于肝脏是一个血管丰富的器官，血管侵犯在HCC患者中尤为常见人们已经认识到microRNA 126 (miR126)对hcc具有保护作用，3,4,5 microRNA (miRNAs)已被发现与人类癌症的发生和进展有关，并对侵袭和转移产生影响。3 miR-126是内皮细胞中表达最丰富的mirna，在内皮细胞中负责血管发育miR-126的两条链:miR-126-3p和miR-126-5p似乎具有生物活性在裸鼠中，miR-126过表达可导致hcc体重减轻和新生血管减少。6已经证实，microRNA-126 (miR-126)异常下调，在几种癌症的致癌过程中起关键作用。研究发现miR-126在人HCC中具有抑瘤作用，miR-126 -3p在HCC中具有抑制侵袭和转移的作用。越来越多的证据表明，miR-126在HCC细胞系和组织中显著降低，并与临床病理参数呈负相关miR-126的低表达水平与hcc的总生存率差、TNM晚期和复发有关。抑制miR-126已被证明可以减少细胞凋亡，增强细胞增殖和肿瘤血管生成在体外实验中，miR126过表达可显著降低细胞增殖转移和促进细胞凋亡。5 miR-126是人类血小板中最丰富的mirna之一。miR-126与血小板功能和反应性有关已经发现血小板在体外激活到周围血浆后提供重要量的miR-126已经确定血小板和血小板微泡释放高水平的miR126，这在很大程度上促成了循环中的miR-126.7阿司匹林治疗似乎导致血小板相关的miR-126.7水平下降。研究发现，健康离体血小板的激活似乎可以促进细胞内miR126的释放，而这一事件被阿司匹林抑制当血小板的激活被阿司匹林阻断时，miR-126的释放已被观察到被撤回综上所述，我推测阿司匹林的使用可能不会对HCC产生保护作用，因为它对循环miR-126水平有负面影响。相反，我认为阿司匹林可能通过其抗血小板活性下调miR126的表达，从而导致HCC的发生。因此，我认为有必要进行进一步的临床试验，以确定阿司匹林是否可以作为一种安全有效的靶向肝癌的药物。
{"title":"Aspirin Use for Primary Prevention of HCC: Friend or Foe?","authors":"R. Mormile","doi":"10.1177/26339447221127081","DOIUrl":"https://doi.org/10.1177/26339447221127081","url":null,"abstract":"Corresponding author: Raffaella Mormile, Division of Pediatrics and Neonatology, Moscati Hospital, Aversa, Italy, Via A. Gramsci-81031, Italy. E-mail: raffaellamormile@alice.it Aspirin use has been suggested to reduce the risk of hepatocellular carcinoma (HCC).1 It has been reported that aspirin may have beneficial effect as a chemopreventive or adjuvant chemotherapeutic agent in HCC.2 The benefit of aspirin in reducing HCC risk has been proposed to be doserelated and apparent after 5 or more years of use.1 However, it is still unclear whether aspirin administration should be recommended to different populations of patients at risk for HCC.2 According to studies in animal models, it has been hypothesized that the mechanism of cancer preventive action of aspirin against HCC may be related to its antiplatelet and anti-inflammatory activities.2 HCC represents one of the most aggressive malignancies, whose prognosis is extremely poor, mainly due to its high propensity of invasion and metastasis.3 To date, an effective therapeutic approach against invasive or/and metastatic HCC still remains rare.3 Vascular invasion is particularly common in patients with HCC given that liver is an organ rich in blood vessels.3 It has been recognized that microRNA 126 (miR126) exerts a protective role against HCC.3,4,5 microRNAs (miRNAs) have emerged to be linked to human cancer onset and progression having an impact on invasion and metastasis.3 miR-126 belongs to the most abundantly expressed miRNAs in endothelial cells where it is responsible for vascular development.4 Both strands of miR-126: miR-126-3p and miR-126-5p, appear to be biologically active.4 Overexpression of miR-126 in nude mice has been tested to result in reduced weight and less new blood vessels in HCC.6 It has been verified that microRNA-126 (miR-126) is aberrantly downregulated and plays a critical role in carcinogenesis in several cancers, including HCC.5 It has been detected that miR-126 functions as a tumor suppressor in human HCC.5 miR126-3p has been demonstrated to counteract invasion and metastasis in HCC.3 Increasing evidence has revealed that miR-126 is markedly reduced in HCC cell lines and tissues as well as negatively connected with clinic-pathologic parameters.5 Low expression levels of miR-126 have been connected with a poor overall survival, late TNM stage, and the presence of recurrence in HCC.5 Inhibition of miR-126 has been proved to reduce cell apoptosis, and enhanced cell proliferation and tumor angiogenesis.6 Over-expression of miR126 has been shown to significantly reduce cell proliferation metastasis and promote apoptosis in vitro.5 miR-126 represents one of the most copious miRNAs in human platelets.7 miR-126 has been linked to platelet function and reactivity.4 Platelets have been discovered to supply important amounts of miR-126 upon activation into the surrounding plasma in vitro.7 Platelets and platelet microvesicles have been identified to discharge high levels of miR12","PeriodicalId":40062,"journal":{"name":"Journal, Indian Academy of Clinical Medicine","volume":"34 1","pages":"51 - 52"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90698527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1177/26339447221146344
P. Indu
{"title":"Vaccines and Beyond","authors":"P. Indu","doi":"10.1177/26339447221146344","DOIUrl":"https://doi.org/10.1177/26339447221146344","url":null,"abstract":"","PeriodicalId":40062,"journal":{"name":"Journal, Indian Academy of Clinical Medicine","volume":"218 1","pages":"5 - 5"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73135998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1177/26339447221131718
P. Srikanth, Shweta Kapote
Children are a country’s greatest asset, so it is profoundly distressing that so many of children have recently been found guilty of horrific crimes such as rape, murder, theft, kidnapping, etc. Movies are recognized to be a powerful medium of influence, and many of them depict the use of alcohol or other drugs as a heroic feat. In other circumstances, the younger generation is influenced by movie scenes. There are approximately 472 million children under the age of 18 in the country, and numerous similar incidents occur every day.1 The National Crime Statistics Bureau (NCRB) reports that 29,768 children were arrested by the police in 2020 for a variety of infractions. The highest crime rate was recorded in Chhattisgarh (21.4%), followed by Madhya Pradesh (16.8%), Jharkhand (0.4%), and Nagaland (0.4%).2 According to the most recent NCRB 2020 report, children were accused of committing rape (937), murder (842), attempted murder (981), injury (5867), and attack on women (1154), kidnapping (725), and theft (6081). The number of youngsters registered as offenders under the Protection of Children from Sexual Offenses (POCSO) Act of 2012, the arms Act 1959, and the Narcotic Drugs and Psychotropic Substances (NDPS) Act 1985 were 1668, 260, and 264 respectively.2 Many offenders are between the ages of 16 and 18. As a result, there is an upsurge in juvenile crime across the country. There was overwhelming preference at the time for severe punishment for the young defendant in the Delhi “Nirbhaya” event. According to the Juvenile Justice Act, a sentence of more than 3 years is not possible if the accused was under 18 at the time of the offence.3 The Juvenile Justice (Care and Protection of Children) Act, 2015, states that minors who commit serious crimes should be charged as majors.3 According to a legal advocate (Civil Laws), several factors, including dysfunctional families, poverty, inadequate education, a decline in moral values, mental disorders, emotional maladjustment, personality traits, peer pressure, and neighborhood influence, will affect children who engage in such criminal offences.4 The mental health professionals have also emphasized the significance of a number of psychosocial factors that contribute to a child’s offensive behavior, including the child’s upbringing, a lack of necessities, the influence of social media, addiction to drugs or alcohol, online gaming, a lack of supervision, hostile parenting practices, a lack of social support, unhealthy coping mechanisms, single parenting, peer pressure, etc. Therefore, identifying these bio-psycho-social determinants and promptly delivering customized bio-psycho-social therapies is the need of the hour. Most children go astray because there is insufficient monitoring and supervision by family members and an inability to recognize what their children are doing wrong. Decades of research all over the world discovered strong links connecting parental behavior and children’s conduct. Parents shou
{"title":"Groove Misplaced Childhood—Supervision Is an Obligatory Defence","authors":"P. Srikanth, Shweta Kapote","doi":"10.1177/26339447221131718","DOIUrl":"https://doi.org/10.1177/26339447221131718","url":null,"abstract":"Children are a country’s greatest asset, so it is profoundly distressing that so many of children have recently been found guilty of horrific crimes such as rape, murder, theft, kidnapping, etc. Movies are recognized to be a powerful medium of influence, and many of them depict the use of alcohol or other drugs as a heroic feat. In other circumstances, the younger generation is influenced by movie scenes. There are approximately 472 million children under the age of 18 in the country, and numerous similar incidents occur every day.1 The National Crime Statistics Bureau (NCRB) reports that 29,768 children were arrested by the police in 2020 for a variety of infractions. The highest crime rate was recorded in Chhattisgarh (21.4%), followed by Madhya Pradesh (16.8%), Jharkhand (0.4%), and Nagaland (0.4%).2 According to the most recent NCRB 2020 report, children were accused of committing rape (937), murder (842), attempted murder (981), injury (5867), and attack on women (1154), kidnapping (725), and theft (6081). The number of youngsters registered as offenders under the Protection of Children from Sexual Offenses (POCSO) Act of 2012, the arms Act 1959, and the Narcotic Drugs and Psychotropic Substances (NDPS) Act 1985 were 1668, 260, and 264 respectively.2 Many offenders are between the ages of 16 and 18. As a result, there is an upsurge in juvenile crime across the country. There was overwhelming preference at the time for severe punishment for the young defendant in the Delhi “Nirbhaya” event. According to the Juvenile Justice Act, a sentence of more than 3 years is not possible if the accused was under 18 at the time of the offence.3 The Juvenile Justice (Care and Protection of Children) Act, 2015, states that minors who commit serious crimes should be charged as majors.3 According to a legal advocate (Civil Laws), several factors, including dysfunctional families, poverty, inadequate education, a decline in moral values, mental disorders, emotional maladjustment, personality traits, peer pressure, and neighborhood influence, will affect children who engage in such criminal offences.4 The mental health professionals have also emphasized the significance of a number of psychosocial factors that contribute to a child’s offensive behavior, including the child’s upbringing, a lack of necessities, the influence of social media, addiction to drugs or alcohol, online gaming, a lack of supervision, hostile parenting practices, a lack of social support, unhealthy coping mechanisms, single parenting, peer pressure, etc. Therefore, identifying these bio-psycho-social determinants and promptly delivering customized bio-psycho-social therapies is the need of the hour. Most children go astray because there is insufficient monitoring and supervision by family members and an inability to recognize what their children are doing wrong. Decades of research all over the world discovered strong links connecting parental behavior and children’s conduct. Parents shou","PeriodicalId":40062,"journal":{"name":"Journal, Indian Academy of Clinical Medicine","volume":"34 1","pages":"47 - 48"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82086578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1177/26339447221130933
Saajid Anwar, Anoushka Agarwal, P. Velammal, S. Menon
Bladder cancer is a common malignancy in women and is the fourth most common malignancy in men. Bladder cancer ranges from nonaggressive and usually noninvasive tumors that recur and require long-term invasive follow-up to aggressive and invasive tumors with high disease-specific mortality. Bacillus Calmette Guerin (BCG) intravesical immunotherapy, a vaccine derived from attenuated Mycobacterium strains - Bovis is one of the most effective bladder cancer therapies currently available. Reactive arthritis has occurred in between 0.5% and 1% of bladder cancer patients treated with intravesical BCG immunotherapy. Here, we present a 66-year-old man diagnosed with urothelial carcinoma undergoing intravesical BCG therapy with high-grade fever and polyarthralgia.
{"title":"Reactive Arthritis after BCG Therapy in Bladder Carcinoma","authors":"Saajid Anwar, Anoushka Agarwal, P. Velammal, S. Menon","doi":"10.1177/26339447221130933","DOIUrl":"https://doi.org/10.1177/26339447221130933","url":null,"abstract":"Bladder cancer is a common malignancy in women and is the fourth most common malignancy in men. Bladder cancer ranges from nonaggressive and usually noninvasive tumors that recur and require long-term invasive follow-up to aggressive and invasive tumors with high disease-specific mortality. Bacillus Calmette Guerin (BCG) intravesical immunotherapy, a vaccine derived from attenuated Mycobacterium strains - Bovis is one of the most effective bladder cancer therapies currently available. Reactive arthritis has occurred in between 0.5% and 1% of bladder cancer patients treated with intravesical BCG immunotherapy. Here, we present a 66-year-old man diagnosed with urothelial carcinoma undergoing intravesical BCG therapy with high-grade fever and polyarthralgia.","PeriodicalId":40062,"journal":{"name":"Journal, Indian Academy of Clinical Medicine","volume":"5 1","pages":"37 - 38"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87519039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1177/26339447221123393
L. Mezni, Farah Elhadadi, M. Meziane, N. Ismaili, L. Benzekri, K. Senouci
Pityriasis lichenoides et varioliformis acuta (PLEVA) is an uncommon skin disorder, clinically characterized by an acute onset of a polymorphic eruption. The disease has an unpredictable course, the pathogenesis is not fully understood, and many treatments have been proposed while self-resolution may occur. Hence, We report a puzzling case of PLEVA in its early stage of transition to a febrile ulceronecrotic Mucha-Habermann disease.
{"title":"Mucha-Habermann Disease: The Quandary Continues","authors":"L. Mezni, Farah Elhadadi, M. Meziane, N. Ismaili, L. Benzekri, K. Senouci","doi":"10.1177/26339447221123393","DOIUrl":"https://doi.org/10.1177/26339447221123393","url":null,"abstract":"Pityriasis lichenoides et varioliformis acuta (PLEVA) is an uncommon skin disorder, clinically characterized by an acute onset of a polymorphic eruption. The disease has an unpredictable course, the pathogenesis is not fully understood, and many treatments have been proposed while self-resolution may occur. Hence, We report a puzzling case of PLEVA in its early stage of transition to a febrile ulceronecrotic Mucha-Habermann disease.","PeriodicalId":40062,"journal":{"name":"Journal, Indian Academy of Clinical Medicine","volume":"74 1","pages":"42 - 44"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74521181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1177/26339447221111604
Abhisek Gautam, H. Mahapatra, V. Batra, L. Pursnani, M. Balakrishnan, Amandeep Singh, S. Patil, M. Prabhakaran
Minimal change disease has been associated with different types of vaccinations, and several case reports have associated the development of this disease with COVID vaccinations as well. We present here a case report of a 19-year-old male who developed minimal change nephrotic syndrome following the second dose of Covishield ChAdOx1 nCoV vaccine. He had received his first dose 2 months prior which was uneventful. He developed fever 3 days after second vaccination and 1 week later developed edema, frothuria, and oliguria. His reports showed a 24-h urine protein of 3.7 g per day, serum creatinine of 1.9 mg/dL, and serum albumin of 1.9 g/dL. He underwent a kidney biopsy which showed features consistent with minimal change disease. He was started on prednisolone at 1 mg/kg body weight. He responded well to treatment and attained complete remission after 33 days of steroids with 24-h urine protein of 195 mg/day, serum creatinine of 0.6 mg/dL, and serum albumin of 5.1 g/dL. This case highlights the possibility of occurrence of minimal change disease post Covishield vaccination even after the second dose despite an uneventful first dose.
{"title":"Minimal Change Disease After Second Dose of Covishield Vaccination","authors":"Abhisek Gautam, H. Mahapatra, V. Batra, L. Pursnani, M. Balakrishnan, Amandeep Singh, S. Patil, M. Prabhakaran","doi":"10.1177/26339447221111604","DOIUrl":"https://doi.org/10.1177/26339447221111604","url":null,"abstract":"Minimal change disease has been associated with different types of vaccinations, and several case reports have associated the development of this disease with COVID vaccinations as well. We present here a case report of a 19-year-old male who developed minimal change nephrotic syndrome following the second dose of Covishield ChAdOx1 nCoV vaccine. He had received his first dose 2 months prior which was uneventful. He developed fever 3 days after second vaccination and 1 week later developed edema, frothuria, and oliguria. His reports showed a 24-h urine protein of 3.7 g per day, serum creatinine of 1.9 mg/dL, and serum albumin of 1.9 g/dL. He underwent a kidney biopsy which showed features consistent with minimal change disease. He was started on prednisolone at 1 mg/kg body weight. He responded well to treatment and attained complete remission after 33 days of steroids with 24-h urine protein of 195 mg/day, serum creatinine of 0.6 mg/dL, and serum albumin of 5.1 g/dL. This case highlights the possibility of occurrence of minimal change disease post Covishield vaccination even after the second dose despite an uneventful first dose.","PeriodicalId":40062,"journal":{"name":"Journal, Indian Academy of Clinical Medicine","volume":"89 8","pages":"24 - 27"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72424283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1177/26339447221103023
Riya Kataria, N. Senthil, Suja Lakshmanan, A. Anil
Infective endocarditis is an infection commonly caused by bacterial pathogens and is known to affect intracardiac structures. We herein report a previously healthy man who presented with complications of infective endocarditis caused by Enterococcal faecalis and was further managed with appropriate antibiotics without the needed surgical interventions.
{"title":"A Successful Medical Management of Enterococcal Endocarditis Presenting as Cellulitis","authors":"Riya Kataria, N. Senthil, Suja Lakshmanan, A. Anil","doi":"10.1177/26339447221103023","DOIUrl":"https://doi.org/10.1177/26339447221103023","url":null,"abstract":"Infective endocarditis is an infection commonly caused by bacterial pathogens and is known to affect intracardiac structures. We herein report a previously healthy man who presented with complications of infective endocarditis caused by Enterococcal faecalis and was further managed with appropriate antibiotics without the needed surgical interventions.","PeriodicalId":40062,"journal":{"name":"Journal, Indian Academy of Clinical Medicine","volume":"07 1","pages":"19 - 23"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80039979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1177/26339447221123401
K. Vysakha, Jyothi Edakalavan, Lakshmy M Rajappan, Sasikumari O, Shahul Hameed
Aspergillosis species of fungus causes invasive disease in the setting of immunocompromise. Of the various manifestations, invasive aspergillosis is the severest form and failure to timely identify and treat the infection will lead to mortality and morbidity. The difficult task is to isolate the pathogen and confirm the diagnosis as the criteria for the same are stringent. In the setting of severe COVID-19, this poses a risk, especially in a resource-limited setting. We report a case of Covid-associated pulmonary aspergillosis in a resource-limited setting which was confirmed by histopathologic. We would like to highlight that a high index of suspicion and evaluation in the right setting is necessary to identify the pathogen.
{"title":"Covid-Associated Pulmonary Aspergillosis: Does Law of Parsimony Always Work in Resource-Limited Setting?","authors":"K. Vysakha, Jyothi Edakalavan, Lakshmy M Rajappan, Sasikumari O, Shahul Hameed","doi":"10.1177/26339447221123401","DOIUrl":"https://doi.org/10.1177/26339447221123401","url":null,"abstract":"Aspergillosis species of fungus causes invasive disease in the setting of immunocompromise. Of the various manifestations, invasive aspergillosis is the severest form and failure to timely identify and treat the infection will lead to mortality and morbidity. The difficult task is to isolate the pathogen and confirm the diagnosis as the criteria for the same are stringent. In the setting of severe COVID-19, this poses a risk, especially in a resource-limited setting. We report a case of Covid-associated pulmonary aspergillosis in a resource-limited setting which was confirmed by histopathologic. We would like to highlight that a high index of suspicion and evaluation in the right setting is necessary to identify the pathogen.","PeriodicalId":40062,"journal":{"name":"Journal, Indian Academy of Clinical Medicine","volume":"21 1","pages":"32 - 36"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83125042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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