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Application of Graph Theory in DNA similarity analysis of Evolutionary Closed Species. 图论在进化封闭物种DNA相似性分析中的应用。
Pub Date : 2021-01-01 DOI: 10.17762/PAE.V58I1.1282
W. Karunasena, G. Wijesiri
DNA is a complex molecule that consists of biological information that is passed down from generation to generation. With the evolution over time, there are different kinds of species that evolved from a common ancestor because of the occurrence of DNA sequence rearrangements. DNA sequence similarity analysis is a major challenge since the number of sequences is rapidly increasing in the DNA database. In this research, we based a mathematical method to analyze the similarity of two DNA sequences using Graph Theory. This mathematical method started by modeling a weighted directed graph for each DNA sequence, constructing its adjacency matrix, and converting it to the representative vector for each graph. From these vectors, the similarity was determined by distance measurements such as Euclidean, Cosine, and Correlation. By keeping this method as the based method, we will check whether it is applicable for any DNA fragments in considered genomes and molecular similarity coefficients can be used as distance measurements. We will obtain similarities using the graph spectrum instead of the representative vector. Then we will compare the results from the representative vector and that of the graph spectrum. The modified method is tested by using the mitochondrial DNA of Human, Gorilla, and Orangutan. It gives the same result when the number of nucleotides in DNA fragments is increased.
DNA是一种复杂的分子,由代代相传的生物信息组成。随着时间的推移,由于DNA序列重排的发生,从一个共同的祖先进化出了不同种类的物种。随着DNA数据库中序列数量的迅速增加,DNA序列相似性分析是一个重大挑战。在本研究中,我们基于图论的数学方法来分析两个DNA序列的相似性。该数学方法首先为每个DNA序列建模加权有向图,构造其邻接矩阵,并将其转换为每个图的代表向量。从这些向量,相似性是由距离测量,如欧几里得,余弦和相关性确定。通过将该方法作为基础方法,我们将检查它是否适用于考虑的基因组中的任何DNA片段,并且分子相似性系数可以用作距离测量。我们将使用图谱而不是代表性向量来获得相似度。然后将代表性向量的结果与图谱的结果进行比较。利用人类、大猩猩和猩猩的线粒体DNA对改进后的方法进行了测试。当DNA片段中核苷酸的数量增加时,结果也是一样的。
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引用次数: 1
Legal status of pharmaceutical industry secrecy In the UAE legal system 制药工业保密在阿联酋法律体系中的法律地位
Pub Date : 2020-10-03 DOI: 10.17762/PAE.V58I1.1515
Jihad S Younes
Facing the problem of matching growth and status, starting work, starting work, starting work, starting work, starting work, starting work, starting work, and the United Arab Emirates. This harmonization - by approving a set of exceptions of this nature has some of the effects and the secret idea behind it. As we see him, he relied on the idea of ​​public order in order to set some exceptions related to the inventions themselves by excluding some of them from the requirement to obtain a patent certificate, which is stipulated in Article 6 of the Law on the Organization and Protection of Industrial Property, and he also made exceptions related to the rights established for the inventor, which are It gives him the power to monopolize and dominate the invention if the inventor has what is in conflict with the objectives of scientific research, which is stipulated in Article 19 of the aforementioned law, and we see that the UAE legislator has organized the idea of ​​compulsory licensing contracts for pharmaceutical products in accordance with the interests of both the licensee and the licensee. Both. Research problem: considering that the pharmaceutical industry in the UAE is a strategic industry, and because of the fluctuation of drug prices in the global and local market. Therefore, the problem of this research will focus not on the extent to which the pharmaceutical industry in the Emirates can activate its role in the UAE national economy in light of the UAE pharmaceutical legislation, and whether these legislations were able to create a balance between secrecy in the pharmaceutical industry and scientific progress in this industry. research assumes: 1- There is no relationship between advances in the pharmaceutical industry in the UAE and the confidentiality imposed by the TRIPS Agreement. 2- The UAE’s accession to the TRIPS Agreement had a negative impact on the pharmaceutical industry. 3- The Emirati legislator was able to create a consensus between commitment to confidentiality and the manufacture of medicines. research aims: 1- Introducing confidentiality in the pharmaceutical industry. 2- Identifying the main obstacles to the pharmaceutical industry in the UAE. 3- Developing proposals to activate the role of local legislation to create a balance between confidentiality and the pharmaceutical industry. research importance: The importance of the research lies in focusing on the balance between confidentiality and the local pharmaceutical industry to have a developmental role. Thus, we will try to reveal the state of the pharmaceutical industry in the UAE. And how to stimulate the pharmaceutical industry through national legislation Research methodology: The researcher will rely on a descriptive approach to analyze and characterize the special industrial reality in medicine in the UAE and analyze private legislation Based on the foregoing, and in order to understand the position of the Emirati legislator on the idea of ​​secrecy
面对成长与地位匹配的问题,开始工作,开始工作,开始工作,开始工作,开始工作,开始工作,开始工作,开始工作,开始工作,和阿联酋。这种协调-通过批准一系列这种性质的例外有一些效果和背后的秘密思想。正如我们所看到的,他依靠公共秩序的理念来设定一些与发明本身相关的例外,通过将其中一些排除在获得专利证书的要求之外,这是《工业产权组织和保护法》第6条规定的,他还制定了与为发明人建立的权利相关的例外,这给了他垄断和支配发明的权力,如果发明人有与科学研究目标相冲突的东西,这是上述法律第19条规定的,我们看到阿联酋立法者根据被许可人和被许可人的利益组织了医药产品强制许可合同的想法。两者都有。研究问题:考虑到阿联酋的制药行业是战略性行业,并且由于全球和当地市场的药品价格波动。因此,本研究的问题将不集中在阿联酋制药立法能够在多大程度上激活其在阿联酋国民经济中的作用,以及这些立法是否能够在制药行业的保密性和该行业的科学进步之间建立平衡。研究假设:1-阿联酋制药业的进步与TRIPS协议规定的保密之间没有关系。2-阿联酋加入TRIPS协议对制药业产生了负面影响。3-阿联酋立法者能够在保密承诺和药品生产之间达成共识。研究目的:1-在制药行业引入保密。确定阿联酋制药业的主要障碍。3-提出建议,激活地方立法的作用,在保密和制药行业之间建立平衡。研究的重要性:研究的重要性在于注重保密性与当地医药行业之间的平衡,具有发展作用。因此,我们将试图揭示阿联酋制药行业的现状。以及如何通过国家立法来刺激制药业的研究方法:研究者将依靠描述性的方法来分析和表征阿联酋医药行业的特殊工业现实,并在此基础上分析私人立法,为了更多地了解阿联酋立法者对制药业保密理念的立场,这一要求必须分为两个研究。首先,我们回顾了制药行业的保密概念。第二:共同努力减轻制药行业保密的负面影响。
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引用次数: 0
CRYPTOCURRENCY: AN INSIGHT INTO THE MALAYSIAN REGULATORY APPROACH 加密货币:对马来西亚监管方法的洞察
Pub Date : 2020-09-10 DOI: 10.17762/PAE.V58I2.2319
N. Nawang, I. Azmi
Cryptocurrency like Bitcoin, Ethereum and many others are closely affiliated with the financial technology (fintech) industry. These digital or virtual currencies are encrypted using cryptography and distributed on public ledger (blockchain) across decentralised peer-to-peer (P2P) networks. Since cryptocurrencies are issued by private entities and technically beyond the controls of any states, they may be exploited by criminals for illicit purposes such as money laundering, terrorism financing and many others. Thus, this article will examine whether cryptocurrency amounts to a new form of money under the existing rules on financial services and analyse how it should be regulated. This study is a qualitative research that adopts pure legal research methodology by analysing existing laws on national currency and digital currency. Further, the study analysed other secondary sources including academic books, journal articles, conference papers, and other materials in newspapers or reputable websites. The output of the research is expected to provide an overview on the regulatory framework for cryptocurrency in Malaysia. In conclusion, the government has favoured a minimalist approach so as not to stiffen the innovation and future development of cryptocurrency in the country.
比特币、以太坊等加密货币与金融科技(fintech)行业密切相关。这些数字或虚拟货币使用密码学进行加密,并分布在分散的点对点(P2P)网络上的公共分类账(区块链)上。由于加密货币是由私人实体发行的,在技术上不受任何国家的控制,因此它们可能被犯罪分子利用,用于洗钱、恐怖主义融资等非法目的。因此,本文将研究在现有的金融服务规则下,加密货币是否相当于一种新的货币形式,并分析应如何对其进行监管。本研究是一项定性研究,采用纯法律研究的方法,通过分析国家货币和数字货币的现行法律。此外,该研究还分析了其他二手资源,包括学术书籍、期刊文章、会议论文以及报纸或知名网站上的其他材料。该研究的成果预计将提供马来西亚加密货币监管框架的概述。总之,政府倾向于采取极简主义的方法,以免加强该国加密货币的创新和未来发展。
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引用次数: 6
REASONS FOR CHOOSING ARABIC LANGUAGE AS A THIRD LANGUAGE: A CASE STUDY IN UITM PERAK 选择阿拉伯语作为第三语言的原因:以马来西亚为例
Pub Date : 2020-08-25 DOI: 10.17762/PAE.V58I2.2306
Muhammad Anas Al-Muhsin, K. Mohd, Nur Syafiqah Subri, Nurul Afifa Ishak
With the increasing demand for Arabic courses in universities in Malaysia, it shows that students has their own reasons for choosing Arabic Language to study. The Arabic as a third language course is an elective subject offered to undergraduate students in UiTM. Starting from June 1999, UiTM has decided that third language courses should become one of the university’s requirement subjects, making it compulsory to all first degree students.  The purpose of this study was to identify the reasons of UiTM students for choosing to study Arabic Language as their third language. The sampling involves 320 students from UiTM, who have enrolled in level 1, 2 and 3 Arabic course. This quantitative field research employs questionnaires and purposive sampling technique as the methods of data collection. The main findings are: most of them choose to learn Arabic language because it is the language of Islam and for them to understand more about Islam and also for worshipping purpose. Besides, most of them choose to learn the language for the purpose of their future career.
随着马来西亚大学对阿拉伯语课程的需求不断增加,这表明学生选择阿拉伯语学习有自己的原因。阿拉伯语作为第三语言的课程是为阿联酋理工大学本科生开设的选修课程。自1999年6月起,澳门科技大学决定将第三语文课程列为大学必修科目之一,所有学士学位学生都必须修这门课程。本研究的目的是确定UiTM学生选择学习阿拉伯语作为第三语言的原因。抽样调查涉及来自联合理工大学的320名学生,他们参加了1级、2级和3级阿拉伯语课程。本定量实地研究采用问卷调查和目的抽样技术作为数据收集方法。主要发现是:大多数人选择学习阿拉伯语,因为这是伊斯兰教的语言,让他们更多地了解伊斯兰教,也出于崇拜的目的。此外,他们中的大多数人选择学习语言是为了他们未来的职业生涯。
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引用次数: 2
Political Connection and Enterprise Development (A case study of Nishat Business Group) 政治关系与企业发展(以尼沙特集团为例)
Pub Date : 2020-07-06 DOI: 10.33094/26410249.2020.21.8.25
A. Shoukat
This paper explores what role political connections of any business group of developing country have in its expansion and growth. Starting from explaining the different mediums through which business groups are related to politics, we focus to investigates a little studied but common mechanism that firms use to obtain state favors: business owners use political connections to seek influence to the top offices and commercial banks. Using Pakistan’s biggest private business group as a case study, we find that the accessibility to loans of the business group in favored political regimes is beyond the approved range. Once their favored ruling party is in power, the debt to equity ratio of these firms had increased dramatically without supportive increase in ROA and ROE. Same as, the other descriptive discussion on the strategic decisions of this group enabled us to infer about the benefits business group had availed during its favored regimes. So we conclude that the political power does influence the financing strategies of politically connected business group. Due to which their accessibility to bank loans facilitated them to expand their businesses and capture more market share.
本文探讨了发展中国家任何一个商业集团的政治关系在其扩张和成长过程中所起的作用。从解释商业集团与政治相关的不同媒介开始,我们重点调查了企业用来获得国家恩惠的一种研究不多但常见的机制:企业主利用政治关系寻求对高层办公室和商业银行的影响。以巴基斯坦最大的私营企业集团为例,我们发现,在受青睐的政治体制下,该企业集团的贷款可及性超出了批准范围。一旦他们支持的执政党执政,这些公司的债务股本比急剧增加,没有支持ROA和ROE的增加。同样的,另一个关于该集团战略决策的描述性讨论使我们能够推断出商业集团在其有利的制度下所获得的利益。因此,我们得出结论,政治权力确实会影响政治关联企业集团的融资策略。由于他们获得银行贷款的便利,他们扩大了业务,占据了更多的市场份额。
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引用次数: 1
Analysis Of Constructive Learning Models In Forming Religious Characters Of Early Childhood 幼儿宗教品格形成的建构性学习模式分析
Pub Date : 2020-06-15 DOI: 10.15294/ijeces.v9i1.38141
M. Mulyati, Tjipto Sumadi, E. Yetti
The purpose of this study is to provide an overview of the development of learning models that can stimulate students to interpret every learning activity in shaping the character of early childhood. The research method is a qualitative method in which the researcher captures the phenomenon of the development of religious and moral values of early childhood is only limited to habituation and the discovery of data that the teacher does not compile a special program of character development in learning. The study was conducted in  Jakarta with 60 samples consisting of University students Open early childhood education programs  majors who are early childhood education programs teachers in DKI Jakarta. Data analysis techniques from interviews, observation and questionnaire distribution and also documentation. The results of the study stated that a constructive learning model is needed that is able to give meaning to the learning process in character development
本研究的目的是概述学习模式的发展,这些模式可以激发学生在塑造幼儿性格的过程中解释每一个学习活动。研究方法是一种定性的方法,研究者捕捉到幼儿的宗教和道德价值观的发展仅限于习惯化的现象,并发现教师在学习中没有编制专门的品格发展计划的数据。这项研究是在雅加达进行的,有60个样本,包括在雅加达DKI担任早期儿童教育课程教师的开放幼儿教育专业的大学生。数据分析技术从访谈,观察和问卷调查分发和文件。研究结果表明,需要一种建设性的学习模式,使品格发展的学习过程具有意义
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引用次数: 0
The Effectiveness of Information Service in Improving Students’ Self Control Against Sexual Harassment in Vocational School in Padang 巴东职业学校信息服务在提高学生对性骚扰自我控制中的作用
Pub Date : 2019-01-23 DOI: 10.31227/osf.io/x5n9a
F. Firman, H. Nirwana, Yeni Karneli, R. Hariko, S. Syahniar
Information service as one type of guidance and counseling services in schools has lost its function in helping students to control themselves from performing sexual harassment. This research aims to determine the effectiveness of information service in improving students’ self control against sexual harassment. This is a quantitative research with an experimental design. The research population is students of a Vocational School in Padang and the sampling technique is cluster random sampling. Data collection was performed through a questionnaire on self-control and data were analyzed using t test. The results of the test reveal that information service is effective in improving students’ self control against sexual harassment, with the help of Guidance and Counseling teachers/ the school’s Counselor to prevent sexual harassment in schools.
信息服务作为学校的一种指导和咨询服务,在帮助学生控制性骚扰行为方面已经失去了作用。本研究旨在确定信息服务在提高学生对性骚扰的自我控制能力方面的有效性。这是一项具有实验设计的定量研究。研究对象为巴东某职业学校学生,抽样方法为整群随机抽样。数据收集采用自我控制问卷,数据分析采用t检验。测试结果表明,信息服务在提高学生对性骚扰的自我控制能力方面是有效的,在辅导教师/学校辅导员的帮助下,预防校园性骚扰。
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引用次数: 1
期刊
Psychology and Education Journal
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