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ISFRI Guidelines Working Group: Best practice standards for non-contrast postmortem computed tomography (PMCT) of overdose ISFRI指南工作组:过量非对比死后计算机断层扫描(PMCT)的最佳实践标准
IF 0.8 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-04-25 DOI: 10.1016/j.fri.2025.200635
Jamie Elifritz , Heather Jarrell , Fabrice Dedouit , Laura Filograna , ISFRI guidelines Working Group
Postmortem computed tomography (PMCT) has emerged as a valuable tool in forensic investigations, supporting the investigation of suspected overdoses. While not specific, Cerebral edema, pulmonary edema, and urinary bladder distention (the overdose triad) can suggest overdose in unsuspected cases. Furthermore, a high-density basal layer in the stomach may indicate intentional therapeutic medical overdose. Challenges include short agonal intervals and decomposition changes. Confirmatory blood toxicology is necessary. Dual-energy computed tomography (DECT) can play a role in differentiation of material contributing to dense basal layers and body packing scenarios. PMCT serves as a valuable complement to autopsy findings, aiding in the assessment of internal pathology while also offering a non-invasive alternative in specific forensic contexts where autopsy may not be performed.
尸体计算机断层扫描(PMCT)已成为法医调查的一种有价值的工具,支持对疑似过量用药的调查。脑水肿、肺水肿和膀胱膨胀(“过量三联征”)虽然没有特异性,但可能提示在未被怀疑的病例中过量用药。此外,胃中高密度的基底层可能表明有意的治疗性药物过量。挑战包括短时间间隔和分解变化。确认血液毒理学是必要的。双能计算机断层扫描(DECT)可以在导致致密基底层和身体堆积的材料分化中发挥作用。PMCT是对尸检结果的宝贵补充,有助于评估内部病理,同时也为无法进行尸检的特定法医环境提供非侵入性替代方案。
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引用次数: 0
A deep-learning-aided diagnosis of drowning using post-mortem lung computed tomography 用死后肺计算机断层扫描深度学习辅助诊断溺水
IF 0.8 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-04-25 DOI: 10.1016/j.fri.2025.200629
Amber Habib Qureshi, Takuro Ishii, Yoshifumi Saijo
Identifying the cause of death using postmortem CT images is crucial since it provides a non-invasive, objective approach for forensic investigations while offering significant advantages in terms of time efficiency and cost-effectiveness compared to traditional autopsy methods. However, due to varied lung conditions in the postmortem CT images, a standardized method to diagnose drowning using CT images has not been established. This study aimed to devise a deep-learning-aided framework for diagnosing drowning from postmortem lung CT images. First, to find the suitable convolutional neural network (CNN) architecture for classifying lung CT images into drowning and non-drowning cases, three well-known CNNs, AlexNet, VGG16, and MobileNet, were trained with a single-institute postmortem CT image dataset and the performance and generalizability were also evaluated using images extracted from a public decedent CT image database. The results showed that VGG16 architecture outperformed the three models with the highest mean AUC-ROC and accuracy values of 88.42 % and 80.56 % respectively for drowning image classification, as well as the highest generalizability with an AUC-ROC of 71.79 % on a public image dataset. Additionally, the case-based diagnosis was performed using probability scores given from the model to each slice taken in the same subject. The final diagnosis accuracy was 96 % on the original dataset and 79 % on the public dataset, showing the strong potential that the devised framework can be used as a screening tool to identify drowning cases using postmortem CT images.
使用死后CT图像确定死因至关重要,因为它为法医调查提供了一种非侵入性、客观的方法,同时与传统尸检方法相比,在时间效率和成本效益方面具有显著优势。然而,由于死后CT图像中肺部状况的不同,尚未建立一种标准化的方法来诊断溺水。本研究旨在设计一个深度学习辅助框架,用于从死后肺部CT图像中诊断溺水。首先,为了找到合适的卷积神经网络(CNN)架构,将肺部CT图像分类为溺水和非溺水病例,使用单个机构的尸体CT图像数据集训练三个著名的CNN, AlexNet, VGG16和MobileNet,并使用从公开的死者CT图像数据库中提取的图像来评估其性能和泛化性。结果表明,VGG16架构在溺水图像分类上的平均AUC-ROC最高,准确率分别为88.42%和80.56%,在公共图像数据集上的泛化性最高,AUC-ROC为71.79%。此外,基于病例的诊断是使用从模型到同一受试者的每个切片给出的概率分数进行的。原始数据集的最终诊断准确率为96%,公共数据集的最终诊断准确率为79%,表明所设计的框架可以用作使用死后CT图像识别溺水病例的筛查工具的巨大潜力。
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引用次数: 0
Stature estimation based on vertical measurements of the skull using three-dimensional images from postmortem computed tomography in a Japanese population 基于日本人群死后计算机断层扫描三维图像的头骨垂直测量的身高估计
IF 0.8 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-04-18 DOI: 10.1016/j.fri.2025.200628
Shoken Suzuki , Maki Ohtani , Yuhei Matsuo , Masayuki Fukuda , Sohtaro Mimasaka
We aimed to evaluate the correlation between stature and vertical skull measurements based on three-dimensional (3D) computed tomography (CT) images, develop a stature estimation formula, and validate it in a Japanese population. The “training” and “validation” datasets consisted of 275 and 49 identified individuals who underwent postmortem CT. Two skull measurements, the linear distances from the basion to the bregma (Basion–Bregma) and the posterior nasal spine to the bregma (PNS–Bregma), were obtained from 3D CT images that solely extracted cranial data. Pearson product-moment correlation coefficients assessed stature-skull correlations. Multiple regression analysis was performed to assess whether stature was dependent on sex. A stature estimation formula was developed based on the regression analysis. Validation tests were performed for each formula. Significant correlations were observed between stature and skull measurements. The correlation coefficients were 0.790 for stature and Basion–Bregma, and 0.782 for stature and PNS–Bregma. Sex status was statistically significant as an independent variable in regression analysis and influences the estimation of stature. For the stature estimation formula, the coefficient of determination adjusted for the degree of freedom (R*2) was 0.730, and the standard error of estimation (SEE) was 5.55 cm when using three variables: sex status, Basion–Bregma, and PNS–Bregma. The validation test exhibited high reliability; mean error (MA) = 0.10 cm and mean absolute error (MAE) = 4.64 cm. Vertical skull measurements from 3D CT images may be helpful for stature estimation in Japanese individuals, particularly in cases where better predictors are unavailable.
我们的目的是评估基于三维计算机断层扫描(CT)图像的身材与垂直头骨测量值之间的相关性,开发一种身材估算公式,并在日本人群中进行验证。训练 "和 "验证 "数据集分别由 275 人和 49 人组成,他们都接受了尸检 CT。两个头骨测量值,即从基底到前囟的线性距离(Basion-Bregma)和从后鼻骨脊到前囟的线性距离(PNS-Bregma),都是从仅提取头骨数据的三维 CT 图像中获得的。皮尔逊积矩相关系数评估了身材与头骨的相关性。进行多元回归分析以评估身材是否取决于性别。在回归分析的基础上制定了一个身材估算公式。每个公式都进行了验证测试。结果表明,身材与头骨测量值之间存在显著的相关性。身材与 Basion-Bregma 的相关系数为 0.790,身材与 PNS-Bregma 的相关系数为 0.782。在回归分析中,性别状况作为一个自变量对身材的估计有显著的统计学影响。使用性别状况、Basion-Bregma 和 PNS-Bregma 这三个变量估算身材时,经自由度调整的决定系数(R*2)为 0.730,估算标准误差(SEE)为 5.55 厘米。验证测试显示出较高的可靠性;平均误差 (MA) = 0.10 厘米,平均绝对误差 (MAE) = 4.64 厘米。通过三维 CT 图像进行头骨垂直测量可能有助于估计日本人的身材,尤其是在没有更好的预测指标的情况下。
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引用次数: 0
Assessment of knee ossification timings: Development and validation of an ordinal scoring protocol for age estimation using medical imaging 评估膝关节骨化时间:开发和验证使用医学影像进行年龄估计的顺序评分方案
IF 0.8 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-04-17 DOI: 10.1016/j.fri.2025.200625
Taliah Swart , Samantha K. Rowbotham , Soren Blau , Nicolene Lottering

Objectives

Assessing skeletal maturity using epiphyseal and morphological features with modern, reliable evaluation protocols is crucial for human identification efforts and paediatric growth monitoring. This study aims to develop and validate a scoring system for knee skeletal development on post-mortem computed tomography (PMCT) and magnetic resonance imaging (MRI) acquired from Australian and New Mexican children.

Materials & Methods

A protocol for the skeletal knee was developed on 30 PMCT and 30 T2-weighted MRI scans of subadults aged eight- to- 22 years. DICOM image stacks from a Brisbane children’s hospital and the New Mexico Decedent Image Database (NMDID) underwent multiplanar reconstruction and anatomical alignment. The protocol comprised a three- to- six stage scoring process at four epiphyseal fusion and seven maturity indicator sites. Three observers of varying experience levels assessed the images across three days, with reliability quantified using an intraclass correlation coefficient (ICC).

Results

The protocol demonstrated high reliability and consistency, with excellent intraobserver agreement for CT (ICC = 0.985 (95 % CI: 0.93-1.00)) and MRI (ICC = 0.979 (95 % CI: 0.85-1.00)). Mean inter-observer reliability measures were good for CT (ICC = 0.886 (95 % CI: 0.75-0.95)) and MRI (ICC = 0.852 (95 % CI: 0.68-0.95)). The tibial tubercle demonstrated the most variability and long-bone epiphyseal union the least

Conclusions

This research presents a highly reproducible method for assessing skeletal development of the knee in subadults, aligned with modern imaging standards. The methodology will have application in forensic human identification, age confirmation and clinical growth assessment
目的:采用现代可靠的评估方案,利用骨骺和形态学特征评估骨骼成熟度,对于人类识别工作和儿科生长监测至关重要。本研究旨在通过对澳大利亚和新墨西哥儿童的死后计算机断层扫描(PMCT)和磁共振成像(MRI)来开发和验证膝关节骨骼发育的评分系统。材料,方法对30例8 ~ 22岁的亚成人患者进行PMCT和30例t2加权MRI扫描,建立骨性膝关节的扫描方案。来自布里斯班儿童医院的DICOM图像堆栈和新墨西哥已故图像数据库(NMDID)进行了多平面重建和解剖对齐。该方案包括在4个骨骺融合和7个成熟度指标部位进行3到6个阶段的评分过程。三名不同经验水平的观察员在三天内评估了这些图像,并使用类内相关系数(ICC)对可靠性进行了量化。结果该方案具有较高的可靠性和一致性,CT (ICC = 0.985 (95% CI: 0.93-1.00))和MRI (ICC = 0.979 (95% CI: 0.85-1.00))的观察者内一致性很好。CT (ICC = 0.886 (95% CI: 0.75-0.95))和MRI (ICC = 0.852 (95% CI: 0.68-0.95))的平均观察者间信度测量良好。胫骨结节表现出最大的可变性,长骨骨骺愈合最少。结论:本研究提出了一种高度可重复的方法来评估亚成人膝关节骨骼发育,与现代成像标准一致。该方法将在法医人体鉴定、年龄确认和临床生长评估中得到应用
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引用次数: 0
High diagnostic accuracy of postmortem CT for hemothorax with volume estimation challenges: A comparative study with autopsy 死后 CT 对血气胸的诊断准确性很高,但存在体积估计方面的挑战:与尸检的比较研究
IF 0.8 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-04-17 DOI: 10.1016/j.fri.2025.200626
Punpramepree Yeesakhorn , Wanlapha Tungsub , Nitima Saksobhavivat , Wisarn Worasuwannarak

Background

Estimating hemothorax volume via postmortem computed tomography (PMCT) remains challenging because of postmortem artifacts that can impact interpretation and accuracy. This study aimed to evaluate the accuracy of PMCT in estimating hemothorax volume compared with standard autopsy.

Methods

Forty deceased individuals who underwent both PMCT and autopsy were examined. PMCT volumes were manually segmented, and the results were compared with autopsy findings. Spearman's rank correlation and paired t-tests were used to assess accuracy.

Results

PMCT showed a high diagnostic accuracy for hemothorax, with correlation coefficients of 0.859 and 0.794 on the left and right sides, respectively. However, the mean absolute percentage error (MAPE) for volume estimation was relatively high, suggesting caution when relying solely on PMCT for volume estimation.

Conclusion

PMCT is a reliable tool for diagnosing hemothorax; however, its accuracy in volume estimation remains limited for manual segmentation methods. Further refinement of the imaging techniques is required for more precise volume measurements.
通过死后计算机断层扫描(PMCT)估计胸血容量仍然具有挑战性,因为死后的伪影会影响解释和准确性。本研究旨在评估PMCT与标准尸检相比在估计胸血容量方面的准确性。方法对40例同时进行PMCT和尸检的死者进行分析。人工分割PMCT体积,并将结果与尸检结果进行比较。使用Spearman秩相关和配对t检验来评估准确性。结果spmct对血胸的诊断准确率较高,左右两侧的相关系数分别为0.859和0.794。然而,体积估计的平均绝对百分比误差(MAPE)相对较高,建议仅依靠PMCT进行体积估计时要谨慎。结论pmct是诊断血胸的可靠工具;然而,对于人工分割方法,其体积估计的准确性仍然有限。为了更精确地测量体积,需要进一步改进成像技术。
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引用次数: 0
Dental age estimation based on imaging of lower third molars in Western Indian population 基于西印度人口下三磨牙影像的牙龄估计
IF 0.8 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-04-17 DOI: 10.1016/j.fri.2025.200624
Deepa Jatti Patil, Chandramani B. More, Rashmi Venkatesh
The study aimed to determine age by assessing the discernibility of the periodontal ligament (PDL) and root canal (RC) on panoramic radiographs of mandibular third molars. In this retrospective study, 2000 panoramic radiographs of individuals aged between 16 to 40 were analysed, including both males and females. The radiographic discernibility of PDL and RC in mandibular third molars was assessed according to the study by Olze et al. which was categorised into four stages. At each stage, the minimum, maximum, and standard deviation were assessed. Statistical analysis was conducted to examine the relationship between age, sex, and PDL/RC stage. There was a notable disparity in the average age of individuals at different stages of PDL and RC. There was a considerable increase in the average age from PDL & RC stage 0 to stage 3. By considering the minimum and maximum values for each stage, individuals can be classified as being older than 17 years if they are in stage 1, and older than 20 years if they are in stages 2 and 3. These classifications are determined based on the combined results of the PDL and RC stages. The radiographic discernibility of PDL and RC can be utilised as a promising method to determine age in the western Indian population.
本研究旨在通过评估下颌第三磨牙全景x线片牙周韧带(PDL)和根管(RC)的可分辨性来确定年龄。在这项回顾性研究中,分析了2000张年龄在16至40岁之间的个体的全景x线片,包括男性和女性。根据Olze等人的研究,评估下颌第三磨牙PDL和RC的x线片可分辨性,并将其分为四个阶段。在每个阶段,评估最小值、最大值和标准差。统计分析年龄、性别与PDL/RC分期的关系。PDL和RC不同阶段个体的平均年龄存在显著差异。从PDL &;RC阶段0到阶段3。通过考虑每个阶段的最小值和最大值,可以将处于阶段1的个体划分为年龄大于17岁,处于阶段2和阶段3的个体划分为年龄大于20岁。这些分类是根据PDL和RC阶段的综合结果确定的。放射学上PDL和RC的区别可以作为一种有前途的方法来确定西印度人口的年龄。
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引用次数: 0
Stature estimation and craniometry–a computed tomography scan based study in South Indian adult population 身高估计和颅部测量-一项基于南印度成年人的计算机断层扫描研究
IF 0.8 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-04-17 DOI: 10.1016/j.fri.2025.200627
Kirthika Ravi , Siddhartha Das , Ambika Prasad Patra , Deepak Barathi Subramania , Harichandrakumar Kottyen Thazhath

Background

Stature estimation contributes to the identification of an individual which is one of the objectives of a medicolegal autopsy. Stature can be estimated by measuring various landmarks of the cranium. Owing to the geographical variations, the regression formula used for one population may not be applicable to other populations. This CT scan study was conducted with an aim to develop regression formulas for the different cranial parameters in a South Indian adult population.

Methodology

511 patients scheduled for elective CT scans of the head and neck were recruited. Twenty-nine cranial variables were studied in each of these patients. Simple and multivariate linear regression was performed to establish a predictive stature estimation model. Pearson correlation and the predictive stature estimation model were considered significant if the P value was ≤ 0.05.

Results

All the cranial measurements showed a statistically significant correlation with stature in the overall population except for right orbital height, left orbital height and minimum distance between the condyles. The proportion of variance of stature explained by the model was found to be 27 % for the overall population, whereas it was 20 % and 21 % respectively for the males and females.

Conclusion

Our results suggest that the studied cranial measurements have a positive correlation with stature and can be used to estimate the stature, but the R2 values are not so encouraging.
身高估计有助于识别个体,这是法医尸检的目标之一。身高可以通过测量头盖骨的各种标志来估计。由于地理上的差异,用于一个人口的回归公式可能不适用于其他人口。本CT扫描研究进行的目的是开发回归公式的不同颅参数在印度南部的成年人人口。方法招募511例计划择期进行头部和颈部CT扫描的患者。在这些患者中研究了29个颅变量。采用简单线性回归和多元线性回归建立了预测身高的模型。如果P值≤0.05,则认为Pearson相关性和预测身高估计模型显著。结果除右眼眶高度、左眼眶高度和髁间最小距离外,所有颅骨测量值与总体人群身高均有统计学意义。该模型解释的身高差异比例在总人口中为27%,而在男性和女性中分别为20%和21%。结论颅骨尺寸与身高呈正相关,可用于身高的估计,但R2值并不理想。
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引用次数: 0
3D dental images in forensic odontology: A scoping review of superimposition approaches utilizing 3D imaging 法医牙科学中的3D牙科图像:利用3D成像的叠加方法的范围审查
IF 0.8 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-28 DOI: 10.1016/j.fri.2024.200622
Harry Perkins , Thao Liang Chiam , Alex Forrest , Denice Higgins

Background

Forensic odontology is crucial for human identification, especially in disaster scenarios, using comparisons between antemortem and postmortem dental data. Advances in 3D imaging have shifted practices from traditional 2D methods to 3D superimposition techniques, necessitating a comprehensive review. This scoping review maps current 3D superimposition methodologies in forensic odontology, focusing on key processes, sources of error, and research gaps.

Methods

We used Arksey and O'Malley's framework, searching PubMed, Embase, Scopus, and DOSS for studies from January 2017. Search strategies incorporated MeSH and Emtree terms, Boolean operators, and truncations. Inclusion criteria required studies to utilize 3D superimposition techniques for comparing dental imaging, with exclusions for 2D imaging, non-forensic focus, and inaccessible texts. Data were extracted on anatomical features, imaging techniques, methods, and outcomes.

Results

From 545 records, 20 studies met inclusion criteria. Most employed surface-based superimposition. Methodologies varied widely, with inconsistent software use and a lack of standardization. Root Mean Square (RMS) values were commonly used to assess alignment, but thresholds differed significantly across studies. Key challenges include operator variability and limited access to affordable software.

Conclusions

The rapid advancement of 3D imaging in forensic odontology highlights the need for standardized methods. While surface-based techniques are promising, establishing uniform benchmarks and developing open-source tools are crucial for improving reliability and global adoption.
法医牙科学对人类身份识别至关重要,特别是在灾难场景中,通过比较死前和死后的牙齿数据。3D成像的进步已经将传统的2D方法转变为3D叠加技术,因此有必要进行全面的审查。这范围审查地图当前3D叠加方法在法医牙科学,重点是关键过程,错误的来源,和研究差距。方法我们使用Arksey和O'Malley的框架,检索PubMed、Embase、Scopus和DOSS从2017年1月开始的研究。搜索策略包括MeSH和Emtree术语、布尔运算符和截断。纳入标准要求研究利用3D叠加技术来比较牙科成像,排除2D成像、非法医焦点和无法获取的文本。提取有关解剖特征、成像技术、方法和结果的数据。结果545份文献中,20项研究符合纳入标准。大多数采用基于表面的叠加。方法差异很大,软件使用不一致,缺乏标准化。均方根(RMS)值通常用于评估对齐性,但不同研究的阈值差异显著。主要的挑战包括操作人员的可变性和有限的可负担软件。结论随着法医口腔医学三维成像技术的快速发展,迫切需要标准化的三维成像方法。虽然基于表面的技术很有前途,但建立统一的基准和开发开源工具对于提高可靠性和全球采用至关重要。
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引用次数: 0
Development of automatic 3D model comparison (ModelMatch3D) for forensic identification and testing using odontology data 开发自动3D模型比较(ModelMatch3D),用于使用牙科学数据进行法医鉴定和测试
IF 0.8 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-28 DOI: 10.1016/j.fri.2024.200621
Jiwon Choi , Seongwon Choi , Arthur Porto , Harry Perkins , Sanmarié Schlebusch , Denice Higgins , Ove A. Peters , Christine I. Peters , Alex Forrest
Three-dimensional (3D) imaging techniques including radiographic and optical surface scans are used in many medical fields including dentistry. Comparison of the resulting antemortem (AM) and postmortem (PM) data has been limited, partly due to the absence of specialised, affordable software. To address this gap, we introduce ModelMatch3D, an open-source software built upon the established 3D Slicer platform, designed to automate general 3D comparison tasks and enable rapid comparison of 3D surface data. It requires minimal preparation of datasets prior to use.
ModelMatch3D was evaluated using de-identified 3D dental scans sourced from a collection at the University of Adelaide. Dental data was selected due to its recognised importance as one of the three major identifiers by INTERPOL. Although we tested it with dental data, it can be applied to any 3D surface datasets of distinctive shape, extending its utility beyond forensic science.
ModelMatch3D runs on all major operating systems ensuring wide accessibility. It runs well on lower-end systems without discrete graphics capability. Its broad compatibility and minimal computing requirements enable its deployment in diverse forensic environments, providing an easy-to-use, automated method for rapid comparison and where multiple victims are involved, ranking of matches for subsequent expert inspection.
Technically, ModelMatch3D employs advanced algorithms for point cloud processing and feature extraction which enable rapid handling of substantial databases with no need for preprocessing.
We believe that ModelMatch3D fills a gap in forensic identification and opens avenues for comparison of other hard tissues and structures, providing a robust platform for enhancing computational forensics.
三维(3D)成像技术,包括放射成像和光学表面扫描,在许多医学领域,包括牙科使用。所得到的死前(AM)和死后(PM)数据的比较是有限的,部分原因是缺乏专门的、负担得起的软件。为了解决这一差距,我们引入了ModelMatch3D,这是一款基于已建立的3D切片器平台的开源软件,旨在自动完成一般3D比较任务,并实现3D表面数据的快速比较。它在使用前需要最少的数据集准备。ModelMatch3D是使用来自阿德莱德大学收集的去识别3D牙科扫描进行评估的。选择牙科数据是因为国际刑警组织承认其作为三大标识符之一的重要性。虽然我们用牙齿数据进行了测试,但它可以应用于任何独特形状的3D表面数据集,将其用途扩展到法医科学之外。ModelMatch3D运行在所有主要的操作系统上,确保广泛的可访问性。它在没有独立图形功能的低端系统上运行良好。其广泛的兼容性和最低的计算要求使其能够部署在不同的法医环境中,提供一种易于使用的自动化方法,用于快速比较,并在涉及多名受害者的情况下,对匹配进行排序,以便随后的专家检查。在技术上,ModelMatch3D采用先进的算法进行点云处理和特征提取,无需预处理即可快速处理大量数据库。我们相信,ModelMatch3D填补了法医鉴定的空白,并为其他硬组织和结构的比较开辟了途径,为增强计算取证提供了一个强大的平台。
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引用次数: 0
Correlation between epicardial fat volume and postmortem radiological and autopsy findings in cases of sudden death: A pilot study 猝死病例中心外膜脂肪体积与死后放射学和尸检结果的相关性:一项初步研究
IF 0.8 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-23 DOI: 10.1016/j.fri.2024.200620
Jessika Camatti , Anna Laura Santunione , Stefano Draisci , Drago Antonella , Maria Grazia Amorico , Guido Ligabue , Enrico Silingardi , Pietro Torricelli , Rossana Cecchi
Epicardial fat volume (EFV) has recently been recognized as a good predictor of multivessel coronary artery disease, and the Coronary Artery Calcium Score (CACS) is a parameter that estimates the amount of calcium in the coronary tree. Both of these parameters can be assessed non-invasively by cardiac computed tomography. Previous studies have investigated a correlation between autopsy results and radiologically calculated EFV and CACS.
The present study aims to investigate a correlation between EFV and other radiological (CACS and the presence of coronary artery opacification defects on Multi-Phase Post-Mortem Computed Tomography Angiography (MPMCTA)) and autoptic (presence of coronary stenosis) findings, in order to verify whether EFV can be considered a good predictor of radiological and autoptic coronary findings.
A cohort of 21 subjects who died suddenly was examined. Firstly, MPMCTA was performed, then autopsy was carried out. EFV and CACS were radiologically calculated, the detection of opacification defects on MPMCTA was investigated and the presence of coronary stenoses on autopsy was assessed.
21 deceased individuals (51 ± 10,77 years; 19 men) were evaluated. Statistically significant correlations were found between levels of EFV > 125 mL (cut-off indicated for prognostic risk stratification) and CACS > 0 (signifying the presence of coronary calcifications), opacification defects on MPMCTA, and coronary stenosis on autopsy.
The volume of the epicardial fat, detected radiologically, is a promising additional tool in the assessment and risk stratification for sudden death. Further research is needed to better explore the application of radiologically calculated EFV in cases of sudden death.
心外膜脂肪体积(EFV)最近被认为是多支冠状动脉疾病的良好预测指标,冠状动脉钙评分(CACS)是估计冠状动脉树中钙含量的参数。这两个参数都可以通过心脏计算机断层扫描无创地评估。先前的研究调查了尸检结果与放射学计算的EFV和CACS之间的相关性。本研究旨在探讨EFV与其他影像学(CACS和多期死后计算机断层血管造影(MPMCTA)中冠状动脉混浊缺陷的存在)和自噬(冠状动脉狭窄的存在)表现之间的相关性,以验证EFV是否可以被认为是冠状动脉影像学和自噬表现的良好预测指标。研究人员对21名突然死亡的研究对象进行了调查。首先进行MPMCTA检查,然后进行尸检。影像学上计算EFV和CACS,研究MPMCTA上发现的混浊缺陷,并评估尸检时冠状动脉狭窄的存在。死亡21例(51±10.77岁);19名男性)接受评估。EFV和gt水平之间存在统计学上显著的相关性;125ml(预后危险分层临界值)和CACS;0(表示存在冠状动脉钙化),MPMCTA显示不透明缺陷,尸检显示冠状动脉狭窄。心外膜脂肪的体积,放射检测,是一个很有前途的额外工具,在猝死的评估和风险分层。放射学计算EFV在猝死病例中的应用有待进一步研究。
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Forensic Imaging
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