Ines Damayanti Octaviani, Gusti Ayu Maharatih, Adriesti Herdaetha
Insomnia is one of the various symptoms frequently found in patients with post-covid syndrome (PCS) (19.1%). The WHO Stress Management (WSM) is an eclectic psychotherapy that combines mindfulness and relaxation which, theoretically, can be effective in treating insomnia due to PCS. This study aimed to explore the effectiveness of WSM in improving the Insomnia Severity Index Score for people with PCS. This was a quasi-experimental pre-test-post-test control study on 18 participants in the population of online self-isolation group in the Telegram who experienced insomnia. The intervention applied was WSM. These participants were compared to 18 controls who only received psychoeducation. Clinical insomnia symptoms were examined using the Insomnia Severity Index (ISI) before the intervention, then the control group was given sleep hygiene psychoeducation, and the treatment group was given WSM in 5 Zoom on-cam meetings once a week for 30-60 minutes. A re-assessment using the ISI post-test was then performed, and data were analyzed statistically. There was a change in score for insomnia symptoms in the treatment group (delta score 27.50) compared to the control group (delta score 9.50, p=0.00; OR 0.00, p=0,99, 95% CI). Thus, WSM can improve the insomnia score in the population with PCS.
{"title":"Effectiveness of WHO Stress Management for Improving Insomnia Severity Index Score in Telegram’s Self-Isolated Online Group Population","authors":"Ines Damayanti Octaviani, Gusti Ayu Maharatih, Adriesti Herdaetha","doi":"10.15395/mkb.v55n2.2753","DOIUrl":"https://doi.org/10.15395/mkb.v55n2.2753","url":null,"abstract":"Insomnia is one of the various symptoms frequently found in patients with post-covid syndrome (PCS) (19.1%). The WHO Stress Management (WSM) is an eclectic psychotherapy that combines mindfulness and relaxation which, theoretically, can be effective in treating insomnia due to PCS. This study aimed to explore the effectiveness of WSM in improving the Insomnia Severity Index Score for people with PCS. This was a quasi-experimental pre-test-post-test control study on 18 participants in the population of online self-isolation group in the Telegram who experienced insomnia. The intervention applied was WSM. These participants were compared to 18 controls who only received psychoeducation. Clinical insomnia symptoms were examined using the Insomnia Severity Index (ISI) before the intervention, then the control group was given sleep hygiene psychoeducation, and the treatment group was given WSM in 5 Zoom on-cam meetings once a week for 30-60 minutes. A re-assessment using the ISI post-test was then performed, and data were analyzed statistically. There was a change in score for insomnia symptoms in the treatment group (delta score 27.50) compared to the control group (delta score 9.50, p=0.00; OR 0.00, p=0,99, 95% CI). Thus, WSM can improve the insomnia score in the population with PCS.","PeriodicalId":40791,"journal":{"name":"Majalah Kedokteran Bandung-MKB-Bandung Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45758089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Chaidir, D. N. Pascapurnama, Claudia Selviyanti, Cindy Natasha, M. Jihadah, P. Santoso
Indonesia ranks thirdamong countries with the largest number of TB cases after India and China. Globally, more than 3-4% of all TB cases are Multidrug-Resistant Tuberculosis (MDR TB). MDR TB is a more complicated TB that needs extra treatments, which extend treatment time and increase adverse effects. Thus, MDR TB patients and their families often feel demotivated about completing treatment, leading to loss to follow up, which contributes to the never-ending transmission and greatly affects the success rate of the national TB control program. Thus, better knowledge and perception on MDR treatment for patients and families plays a crucial role in dealing with this issue. A cross-sectional study was performed from April to June 2019 to evaluate the effectiveness of visual educational media for TB patients and their caregivers. Participants consisted of 144 patients diagnosed with MDR TB and their caregivers or family members (n=22). A pre-test was administered before an education session by a nurse and visual media were used as the educational material. At the end of the session, a post-test was performed. The post-test score was then compared to the pre-test score to evaluate the session’s effectiveness using the paired t-test. Result showed significant increase in the post-test score (t= 3.249, df=3, p=0.04), with the caregivers attained a higher score, showing better improvement in knowledge after the session compared to the patient group. Hence, the MDR TB educational intervention using visual media is considered effective to increase participants ‘understanding of MDR TB. It is expected that with increased knowledge on MDR TB, the treatment success rate will increase and becomes the catalyst for the nationwide TB control strategy.
{"title":"Effective Visual Media to Increase Knowledge and Comprehension of Multidrug Resistant Tuberculosis Among Patients and Their Caregivers","authors":"L. Chaidir, D. N. Pascapurnama, Claudia Selviyanti, Cindy Natasha, M. Jihadah, P. Santoso","doi":"10.15395/mkb.v55n2.2986","DOIUrl":"https://doi.org/10.15395/mkb.v55n2.2986","url":null,"abstract":"Indonesia ranks thirdamong countries with the largest number of TB cases after India and China. Globally, more than 3-4% of all TB cases are Multidrug-Resistant Tuberculosis (MDR TB). MDR TB is a more complicated TB that needs extra treatments, which extend treatment time and increase adverse effects. Thus, MDR TB patients and their families often feel demotivated about completing treatment, leading to loss to follow up, which contributes to the never-ending transmission and greatly affects the success rate of the national TB control program. Thus, better knowledge and perception on MDR treatment for patients and families plays a crucial role in dealing with this issue. A cross-sectional study was performed from April to June 2019 to evaluate the effectiveness of visual educational media for TB patients and their caregivers. Participants consisted of 144 patients diagnosed with MDR TB and their caregivers or family members (n=22). A pre-test was administered before an education session by a nurse and visual media were used as the educational material. At the end of the session, a post-test was performed. The post-test score was then compared to the pre-test score to evaluate the session’s effectiveness using the paired t-test. Result showed significant increase in the post-test score (t= 3.249, df=3, p=0.04), with the caregivers attained a higher score, showing better improvement in knowledge after the session compared to the patient group. Hence, the MDR TB educational intervention using visual media is considered effective to increase participants ‘understanding of MDR TB. It is expected that with increased knowledge on MDR TB, the treatment success rate will increase and becomes the catalyst for the nationwide TB control strategy.","PeriodicalId":40791,"journal":{"name":"Majalah Kedokteran Bandung-MKB-Bandung Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43172953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bryan Arista Hartono, J. Henrina, Doddy M Turmudzi
Type 1 Diabetes Mellitus (T1DM) is a chronic endocrinological disease due to an autoimmune process. The prevalence of T1DM is 9.5% worldwide, with the incidence of 15 out of 100,000 people, ranging from childhood to 40 years of age. Autoimmunity-related late-onset Diabetes Mellitus (DM) patients could be diagnosed as classic T1DM or latent autoimmune diabetes in adults (LADA). A 30-year-old male patient with unremarkable previous medical history was admitted to the emergency room with dyspnea for the last three days that was worsened six-hour before admission. Physical examinations showed a body Mass Index (BMI) of 18.75 kg/m2, irregular pulse, and Kussmaul breathing. The patient was diagnosed with diabetic ketoacidosis (DKA) on May 23, 2019. He was discharged with subcutaneous insulin pen injections. Two years later, he was readmitted with DKA due to discontinuing his treatment. He stated that the reason for stopping the insulin was because he was tired of injecting it. The patient was hospitalized and was discharged with oral antidiabetic agents to cope with his injection tiredness issue. One week later, the patient complained of dyspnea and was diagnosed with recurrent DKA. He was hospitalized and prescribed subcutaneous insulin. In this kind of situation, a diagnosis of LADA for patients presenting with DKA without prior history of DM in early adulthood needs to be considered. In contrast to the classic T1DM, the need for insulin occurs late in LADA. Affordable and widely available ancillary examinations are needed, including in remote hospitals. Finally, motivational support for patients is as important as the pharmacological treatment since lifelong insulin injections are needed.
{"title":"Diagnostic Challenge of Adult-onset Type 1 Diabetes Mellitus in a Remote Hospital","authors":"Bryan Arista Hartono, J. Henrina, Doddy M Turmudzi","doi":"10.15395/mkb.v55n2.2842","DOIUrl":"https://doi.org/10.15395/mkb.v55n2.2842","url":null,"abstract":"Type 1 Diabetes Mellitus (T1DM) is a chronic endocrinological disease due to an autoimmune process. The prevalence of T1DM is 9.5% worldwide, with the incidence of 15 out of 100,000 people, ranging from childhood to 40 years of age. Autoimmunity-related late-onset Diabetes Mellitus (DM) patients could be diagnosed as classic T1DM or latent autoimmune diabetes in adults (LADA). A 30-year-old male patient with unremarkable previous medical history was admitted to the emergency room with dyspnea for the last three days that was worsened six-hour before admission. Physical examinations showed a body Mass Index (BMI) of 18.75 kg/m2, irregular pulse, and Kussmaul breathing. The patient was diagnosed with diabetic ketoacidosis (DKA) on May 23, 2019. He was discharged with subcutaneous insulin pen injections. Two years later, he was readmitted with DKA due to discontinuing his treatment. He stated that the reason for stopping the insulin was because he was tired of injecting it. The patient was hospitalized and was discharged with oral antidiabetic agents to cope with his injection tiredness issue. One week later, the patient complained of dyspnea and was diagnosed with recurrent DKA. He was hospitalized and prescribed subcutaneous insulin. In this kind of situation, a diagnosis of LADA for patients presenting with DKA without prior history of DM in early adulthood needs to be considered. In contrast to the classic T1DM, the need for insulin occurs late in LADA. Affordable and widely available ancillary examinations are needed, including in remote hospitals. Finally, motivational support for patients is as important as the pharmacological treatment since lifelong insulin injections are needed.","PeriodicalId":40791,"journal":{"name":"Majalah Kedokteran Bandung-MKB-Bandung Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41992842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Finny Alifiyatur Roosyidah, R. Yulia, F. Herawati, Heru Wijono
Diabetic ulcers can progress into tissue death, or gangrene, which create a risk for amputation. Measures for preventing other complications and accelerating wound healing in diabetic ulcers include blood sugar level control, diet adjustment, wound care, antidiabetic drug administration, and comorbid therapy. This leads to the use of various drugs that can potentially trigger drug interactions. This study aimed to identify possible drug interactions in the therapeutic management of diabetic ulcer patients treated in Husada Utama Hospital Surabaya, Indonesia, from January 2020–June 2022. This was a descriptive observational study using retrospective data from medical records. Results showed that 103 types of drugs were administered to 48 research samples with 41 of them experienced drug interactions (n=263 cases). Based on the severity of drug interactions, 31 cases were categorized as major cases (11.79%), with drug-class antibiotic-antiemetic interactions as the most frequent interactions. This study proves that it is essential for doctors and pharmacists.
{"title":"Drug Interactions in Diabetic Ulcer Patients in an Indonesian Private Hospital","authors":"Finny Alifiyatur Roosyidah, R. Yulia, F. Herawati, Heru Wijono","doi":"10.15395/mkb.v55n2.2982","DOIUrl":"https://doi.org/10.15395/mkb.v55n2.2982","url":null,"abstract":"Diabetic ulcers can progress into tissue death, or gangrene, which create a risk for amputation. Measures for preventing other complications and accelerating wound healing in diabetic ulcers include blood sugar level control, diet adjustment, wound care, antidiabetic drug administration, and comorbid therapy. This leads to the use of various drugs that can potentially trigger drug interactions. This study aimed to identify possible drug interactions in the therapeutic management of diabetic ulcer patients treated in Husada Utama Hospital Surabaya, Indonesia, from January 2020–June 2022. This was a descriptive observational study using retrospective data from medical records. Results showed that 103 types of drugs were administered to 48 research samples with 41 of them experienced drug interactions (n=263 cases). Based on the severity of drug interactions, 31 cases were categorized as major cases (11.79%), with drug-class antibiotic-antiemetic interactions as the most frequent interactions. This study proves that it is essential for doctors and pharmacists.","PeriodicalId":40791,"journal":{"name":"Majalah Kedokteran Bandung-MKB-Bandung Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44122215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Baginda Aflah, Erwin Pradian, Nurita Dian Kestriani
This retrospective descriptive study aimed to understand the outcomes of HFNC therapy in severe COVID-19 patients admitted to isolation ICU during the period of January to June 2021 in Dr. Hasan Sadikin General Hospital Bandung, Indonesia. A total of 134 patients with severe COVID-19 were admitted to the isolation ICU and received HFNC. Among them, 44 patients (32.8%, N:134) were successfully weaned from HFNC and 90 patients (67.2%, N:134) failing HFNC with 10 patients (7.5%, N:134) died on HFNC use, 72 patients (53.9%, N:134) died on ventilator use, 4 patients (2.9%, N:134) moved rooms under HFNC use, and 4 patients (2.9%, N:134) moved to non-ICU isolation with ventilator use as the outcome. Patients’ median age was 60 years, most were male (52.3 %, N:134), median BMI was 25.4 kg/m2, with hypertension and diabetes mellitus as the main comorbidities. There was an improvement in the SpO2 on the first day after the use of HFNC. The ROX index had a median value of 3.6 on the first day, with the lowest ROX index of 3.2 and the highest of 4.4 during the treatment time. There was an improvement in the P/F Ratio in successful patients with a median initial P/F Ratio of 86.7 to 200.1 at the end of treatment. Overall, HFNC improves the hypoxemic conditions in early admission but does not correlate with general patient outcomes.
{"title":"Therapeutic Outcome of High Flow Nasal Cannula (HFNC) for Severe COVID-19 Patients in Isolation Intensive Care Unit","authors":"Baginda Aflah, Erwin Pradian, Nurita Dian Kestriani","doi":"10.15395/mkb.v55n2.2875","DOIUrl":"https://doi.org/10.15395/mkb.v55n2.2875","url":null,"abstract":"This retrospective descriptive study aimed to understand the outcomes of HFNC therapy in severe COVID-19 patients admitted to isolation ICU during the period of January to June 2021 in Dr. Hasan Sadikin General Hospital Bandung, Indonesia. A total of 134 patients with severe COVID-19 were admitted to the isolation ICU and received HFNC. Among them, 44 patients (32.8%, N:134) were successfully weaned from HFNC and 90 patients (67.2%, N:134) failing HFNC with 10 patients (7.5%, N:134) died on HFNC use, 72 patients (53.9%, N:134) died on ventilator use, 4 patients (2.9%, N:134) moved rooms under HFNC use, and 4 patients (2.9%, N:134) moved to non-ICU isolation with ventilator use as the outcome. Patients’ median age was 60 years, most were male (52.3 %, N:134), median BMI was 25.4 kg/m2, with hypertension and diabetes mellitus as the main comorbidities. There was an improvement in the SpO2 on the first day after the use of HFNC. The ROX index had a median value of 3.6 on the first day, with the lowest ROX index of 3.2 and the highest of 4.4 during the treatment time. There was an improvement in the P/F Ratio in successful patients with a median initial P/F Ratio of 86.7 to 200.1 at the end of treatment. Overall, HFNC improves the hypoxemic conditions in early admission but does not correlate with general patient outcomes.","PeriodicalId":40791,"journal":{"name":"Majalah Kedokteran Bandung-MKB-Bandung Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41741887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Sumayyah, P. Suryadarma, Rachmawati Noverina, Wireni Ayuningtyas, F. Wirakusumah, A. Faried
Hyperinflammation in COVID-19 patients is one of the causes of the high mortality rate of COVID-19. An in vitro model mimicking the inflammatory responses in COVID-19 patients is important in the efforts of finding new drug candidates for this disease. Lipopolysaccharide (LPS) can increase the proinflammatory cytokine interleukin 8 in response to the presence of foreign substances. This preliminary study sought to explore the use of the A549 cells as an in vitro inflammatory model. This study was conducted from August to November 2022 at the stem cell research and development laboratory of Bio Farma Indonesia. The exposure of 100, 500, and 1000 g/mL doses of LPS administered for 24, 72, and 120 hours on the A549 cells was analyzed for cell viability, population doubling time (PDT), and the presence of proinflammatory cytokine IL-8. The group differences were examined using one- and two-way analysis of variance in IBM SPSS Statistics Version 29, with a p-value of 0.05 considered significant. Cells exposed to a dose of 1000 g/mL LPS had a lower viability and a higher proliferation rate (p<0.05) based on the viability and PDT. Viability, PDT, and pro-inflammatory cytokines showed concentration- and time-dependent responses. Therefore, increased levels of the proinflammatory cytokine IL-8 in cells exposed to LPS at a dose of 1000 g/mL for 24 hours can be used as a mimic to study hyperinflammation in COVID-19 patients.
新冠肺炎患者的炎症是新冠肺炎高死亡率的原因之一。模拟新冠肺炎患者炎症反应的体外模型对于寻找该疾病的新候选药物非常重要。脂多糖（LPS）可增加促炎细胞因子白细胞介素8，以应对外来物质的存在。这项初步研究试图探索A549细胞作为体外炎症模型的用途。这项研究于2022年8月至11月在印度尼西亚Bio-Farma的干细胞研发实验室进行。对A549细胞暴露于100、500和1000 g/mL剂量的LPS 24、72和120小时进行细胞活力、群体倍增时间（PDT）和促炎细胞因子IL-8的存在分析。使用IBM SPSS Statistics Version 29中的单因素和双向方差分析来检验组间差异，p值为0.05被认为是显著的。基于活力和PDT，暴露于1000g/mL LPS剂量的细胞具有较低的活力和较高的增殖率（p<0.05）。活力、PDT和促炎细胞因子显示出浓度和时间依赖性反应。因此，在暴露于1000 g/mL剂量的LPS 24小时的细胞中，促炎细胞因子IL-8水平的增加可以用作研究新冠肺炎患者过度炎症的模拟物。
{"title":"Dose and Time-Dependent Lipopolysaccharide Exposure on A549 Cell Model Influences Pro-Inflammatory Cytokine Interleukin 8","authors":"Sarah Sumayyah, P. Suryadarma, Rachmawati Noverina, Wireni Ayuningtyas, F. Wirakusumah, A. Faried","doi":"10.15395/mkb.v55n2.3143","DOIUrl":"https://doi.org/10.15395/mkb.v55n2.3143","url":null,"abstract":"Hyperinflammation in COVID-19 patients is one of the causes of the high mortality rate of COVID-19. An in vitro model mimicking the inflammatory responses in COVID-19 patients is important in the efforts of finding new drug candidates for this disease. Lipopolysaccharide (LPS) can increase the proinflammatory cytokine interleukin 8 in response to the presence of foreign substances. This preliminary study sought to explore the use of the A549 cells as an in vitro inflammatory model. This study was conducted from August to November 2022 at the stem cell research and development laboratory of Bio Farma Indonesia. The exposure of 100, 500, and 1000 g/mL doses of LPS administered for 24, 72, and 120 hours on the A549 cells was analyzed for cell viability, population doubling time (PDT), and the presence of proinflammatory cytokine IL-8. The group differences were examined using one- and two-way analysis of variance in IBM SPSS Statistics Version 29, with a p-value of 0.05 considered significant. Cells exposed to a dose of 1000 g/mL LPS had a lower viability and a higher proliferation rate (p<0.05) based on the viability and PDT. Viability, PDT, and pro-inflammatory cytokines showed concentration- and time-dependent responses. Therefore, increased levels of the proinflammatory cytokine IL-8 in cells exposed to LPS at a dose of 1000 g/mL for 24 hours can be used as a mimic to study hyperinflammation in COVID-19 patients.","PeriodicalId":40791,"journal":{"name":"Majalah Kedokteran Bandung-MKB-Bandung Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46752484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saskia Oktaviani Puteri, R. Ratnawati, Nura Eky Vikawati
Lung vital capacity of is different for each individual depending on personal characteristics, such as age, body mass index (BMI), and exercise habits or environmental factors, such as exposure to cigarette smoke. This study aimed to determine the relationship between personal characteristics, duration of exposure to cigarette smoke, and lung vital capacity in passive smokers in one of the areas in Indonesia. This study was a cross-sectional observational analytic study conducted during the period of August to September 2019. Data were collected through interviews and measurements using the Contec SP10BT spirometer. Participants were sampled consecutively with only women who did not smoke but had at least one family member who actively smoked and was over 20 years old participated in this study. Women were selected as the population due to the fact that the proportion of passive smokers among women is higher than men, while the age group of above 20 years old was selected with a consideration of the average age for the optimum lung capacity. The relationship between personal characteristics and a history of exposure to cigarette smoke with lung vital capacity was analyzed using Pearson and Spearman correlation test. There is a significant relationship between age, exercise habits, duration of exposure to cigarette smoke, and vital lung capacity (p=0.000; p=0.018; p=0.000) among the participants of the study. However, further research is still needed to be able to generalize this finding into a broader community.
{"title":"Relationship between Age, Exercise Habits, Cigarette Smoke Duration Exposure, and Lung Vital Capacity in Passive Smokers","authors":"Saskia Oktaviani Puteri, R. Ratnawati, Nura Eky Vikawati","doi":"10.15395/mkb.v55n2.2169","DOIUrl":"https://doi.org/10.15395/mkb.v55n2.2169","url":null,"abstract":"Lung vital capacity of is different for each individual depending on personal characteristics, such as age, body mass index (BMI), and exercise habits or environmental factors, such as exposure to cigarette smoke. This study aimed to determine the relationship between personal characteristics, duration of exposure to cigarette smoke, and lung vital capacity in passive smokers in one of the areas in Indonesia. This study was a cross-sectional observational analytic study conducted during the period of August to September 2019. Data were collected through interviews and measurements using the Contec SP10BT spirometer. Participants were sampled consecutively with only women who did not smoke but had at least one family member who actively smoked and was over 20 years old participated in this study. Women were selected as the population due to the fact that the proportion of passive smokers among women is higher than men, while the age group of above 20 years old was selected with a consideration of the average age for the optimum lung capacity. The relationship between personal characteristics and a history of exposure to cigarette smoke with lung vital capacity was analyzed using Pearson and Spearman correlation test. There is a significant relationship between age, exercise habits, duration of exposure to cigarette smoke, and vital lung capacity (p=0.000; p=0.018; p=0.000) among the participants of the study. However, further research is still needed to be able to generalize this finding into a broader community.","PeriodicalId":40791,"journal":{"name":"Majalah Kedokteran Bandung-MKB-Bandung Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47921472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Transurethral resection of the prostate (TURP) is the most frequently used urology surgical method to manage benign prostate hyperplasia (BPH). Despite the relatively efficacious treatment, urethral stricture (US) may form after TURP. The prevalence of the urethral strictures (US) following TURP ranges from 2.2% to 9.8%. The study aimed to identify the predictors of urethral strictures in patients receiving TURP. This study was a retrospective cohort study on patients underwent TURP in Dr. Hasan Sadikin General Hospital Bandung, Indonesia, between 2015 and 2019. Data were obtained from medical records and urology registry of a minimum 12-month follow-up period. Data on patient demographics, estimated volume of the prostate, total resected prostate, and operating time were extracted. Multiple logistic regression was utilized to determine the odds ratio difference between groups. A total of 451 TURP cases were performed between 2015 and 2019, with 22 (4.87%) cases of post TURP US identified. The mean estimated prostate weight was 45.6 g and resected prostate weight was 20.4 g, with a 0.37 gr/min resection rate. Prostate weight, operating time, and duration of catheterization after surgery were not significantly different statistically. Slower resection rate and smaller resected volume are the statistically significant predictors of increased occurrence of urethral stricture (p<0.05). Lower resection rate is also a predictor for urethral stricture after TURP procedure.
{"title":"Predictors of Urethral Stricture After Transurethral Resection of the Prostate Procedure","authors":"Daniel Saputra, A. Agil, A. Mustafa","doi":"10.15395/mkb.v55n2.2763","DOIUrl":"https://doi.org/10.15395/mkb.v55n2.2763","url":null,"abstract":"Transurethral resection of the prostate (TURP) is the most frequently used urology surgical method to manage benign prostate hyperplasia (BPH). Despite the relatively efficacious treatment, urethral stricture (US) may form after TURP. The prevalence of the urethral strictures (US) following TURP ranges from 2.2% to 9.8%. The study aimed to identify the predictors of urethral strictures in patients receiving TURP. This study was a retrospective cohort study on patients underwent TURP in Dr. Hasan Sadikin General Hospital Bandung, Indonesia, between 2015 and 2019. Data were obtained from medical records and urology registry of a minimum 12-month follow-up period. Data on patient demographics, estimated volume of the prostate, total resected prostate, and operating time were extracted. Multiple logistic regression was utilized to determine the odds ratio difference between groups. A total of 451 TURP cases were performed between 2015 and 2019, with 22 (4.87%) cases of post TURP US identified. The mean estimated prostate weight was 45.6 g and resected prostate weight was 20.4 g, with a 0.37 gr/min resection rate. Prostate weight, operating time, and duration of catheterization after surgery were not significantly different statistically. Slower resection rate and smaller resected volume are the statistically significant predictors of increased occurrence of urethral stricture (p<0.05). Lower resection rate is also a predictor for urethral stricture after TURP procedure.","PeriodicalId":40791,"journal":{"name":"Majalah Kedokteran Bandung-MKB-Bandung Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47070751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dian Tjahyadi, B. Irsyad, A. Pramatirta, Santi Andayani
Infertility affects physical and mental health and has various consequences. In vitro fertilization (IVF) is one of the Assisted Reproductive Technology (ART) programs that include several phases, requiring longer time, more patience, and is expensive. This may make women who undergo the ART program to have higher stress level, especially anxiety. This study aimed to determine the relationship between anxiety and quality of life in infertile patients undergoing assisted reproductive technology programs. This was a cross-sectional observational analytic study performed at Aster Fertility Clinic, Dr. Hasan Sadikin General Hospital and Bandung Fertility Center, Limijati Hospital Bandung, Indonesia, from February until April 2020. The analysis was performed using the DASS21 scale and FertiQol count on 27 subjects undergoing the IVF program and 30 control subjects who were pregnant without IVF program. The statistical analyses used to determine the condition of anxiety and the condition of quality of life were the Chi-square and the Mann-Whitney tests, while the relationship between anxiety and quality of life as the main subject was measured using the Spearman correlation test. The anxiety level as measured with the DASS21 instrument in the subject and control groups was 6.2 vs 0.7 with p<0.001. From the analysis of the FertiQol instrument in the subject and control groups, the scores were 79.6 vs. 98.9 for the mind-body domain (p<0.001); 68.8 vs 98.5 for the emotional domain (p < 0.001); 83.2 vs 95.7 for the relational domain (p<0.001); and 77.6 vs 97.6 for the social domain (p<0.001). For the overall FertiQol core domains, the score was 77.3 vs 97.7 (p<0.001). The correlation between anxiety and the FertiQol total core domains were evident from the results of the Spearman correlation test, with an r-value of -0.479 (p<0.001). Therefore, there is a significant negative correlation between anxiety and quality of life.
不孕症影响身体和精神健康，并有各种后果。体外受精(IVF)是辅助生殖技术(ART)项目之一，它包括几个阶段，需要更长的时间，更多的耐心，而且价格昂贵。这可能会使接受抗逆转录病毒治疗的妇女有更高的压力水平，特别是焦虑。本研究旨在确定接受辅助生殖技术治疗的不孕患者的焦虑与生活质量之间的关系。这是一项横断面观察性分析研究，于2020年2月至4月在印度尼西亚万隆的阿斯特生育诊所、哈桑·萨迪金博士综合医院和万隆生育中心、Limijati医院进行。采用DASS21量表和FertiQol计数对27名接受体外受精的受试者和30名未接受体外受精的对照组进行分析。确定焦虑状况和生活质量状况的统计分析采用卡方检验和Mann-Whitney检验，而作为主要被试的焦虑与生活质量的关系采用Spearman相关检验。用DASS21量表测量的受试者和对照组的焦虑水平分别为6.2 vs 0.7, p<0.001。从FertiQol仪器的分析来看，受试者和对照组的心身领域得分分别为79.6比98.9 (p<0.001);情绪领域为68.8比98.5 (p < 0.001);关系域为83.2 vs 95.7 (p<0.001);社会领域的得分为77.6比97.6 (p<0.001)。对于整个FertiQol核心域，得分为77.3比97.7 (p<0.001)。Spearman相关检验结果显示，焦虑与FertiQol总核心域之间存在明显的相关性，r值为-0.479 (p<0.001)。因此，焦虑与生活质量之间存在显著的负相关。
{"title":"Anxiety (DASS21) and the Quality of Life (FertiQol) of Infertile Women Underwent In Vitro Fertilization","authors":"Dian Tjahyadi, B. Irsyad, A. Pramatirta, Santi Andayani","doi":"10.15395/mkb.v55n2.2934","DOIUrl":"https://doi.org/10.15395/mkb.v55n2.2934","url":null,"abstract":"Infertility affects physical and mental health and has various consequences. In vitro fertilization (IVF) is one of the Assisted Reproductive Technology (ART) programs that include several phases, requiring longer time, more patience, and is expensive. This may make women who undergo the ART program to have higher stress level, especially anxiety. This study aimed to determine the relationship between anxiety and quality of life in infertile patients undergoing assisted reproductive technology programs. This was a cross-sectional observational analytic study performed at Aster Fertility Clinic, Dr. Hasan Sadikin General Hospital and Bandung Fertility Center, Limijati Hospital Bandung, Indonesia, from February until April 2020. The analysis was performed using the DASS21 scale and FertiQol count on 27 subjects undergoing the IVF program and 30 control subjects who were pregnant without IVF program. The statistical analyses used to determine the condition of anxiety and the condition of quality of life were the Chi-square and the Mann-Whitney tests, while the relationship between anxiety and quality of life as the main subject was measured using the Spearman correlation test. The anxiety level as measured with the DASS21 instrument in the subject and control groups was 6.2 vs 0.7 with p<0.001. From the analysis of the FertiQol instrument in the subject and control groups, the scores were 79.6 vs. 98.9 for the mind-body domain (p<0.001); 68.8 vs 98.5 for the emotional domain (p < 0.001); 83.2 vs 95.7 for the relational domain (p<0.001); and 77.6 vs 97.6 for the social domain (p<0.001). For the overall FertiQol core domains, the score was 77.3 vs 97.7 (p<0.001). The correlation between anxiety and the FertiQol total core domains were evident from the results of the Spearman correlation test, with an r-value of -0.479 (p<0.001). Therefore, there is a significant negative correlation between anxiety and quality of life.","PeriodicalId":40791,"journal":{"name":"Majalah Kedokteran Bandung-MKB-Bandung Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46872432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.1163/21983534-10020003
Herlin Chien, I. Rado
Due to the concentration of people and industries, cities are the main human habitats where residents can create opportunities for flourishing economic, political and social lives. However, these diverse anthropogenic activities also create flows of material and energy within cities that are inevitably produced and wasted. In order to investigate how cities can better reduce and repurpose the flows of material and energy, this paper adopts the urban metabolism approach to frame cities as a complex socio-ecological system where natural and human systems co-produce the environment the urban population depends on. To illustrate urban metabolism at work, we have selected Thaklong municipality in Thailand and Pingtung county in Taiwan as case studies to compare different innovative measures taken by university departments to reduce organic waste through action research oriented repurposing experiments. Although the size of the cities, the type of targeted organic waste varies and local culture differs, the case studies of Thaklong and Pingtung show that the university departments as change agents and the stakeholders as recipients of proposed change face similar opportunities and challenges.
{"title":"University Departments as Change Agents in the Organic Waste Management Sector: Lessons from Action Research Initiatives in Thailand and Taiwan","authors":"Herlin Chien, I. Rado","doi":"10.1163/21983534-10020003","DOIUrl":"https://doi.org/10.1163/21983534-10020003","url":null,"abstract":"\u0000Due to the concentration of people and industries, cities are the main human habitats where residents can create opportunities for flourishing economic, political and social lives. However, these diverse anthropogenic activities also create flows of material and energy within cities that are inevitably produced and wasted. In order to investigate how cities can better reduce and repurpose the flows of material and energy, this paper adopts the urban metabolism approach to frame cities as a complex socio-ecological system where natural and human systems co-produce the environment the urban population depends on. To illustrate urban metabolism at work, we have selected Thaklong municipality in Thailand and Pingtung county in Taiwan as case studies to compare different innovative measures taken by university departments to reduce organic waste through action research oriented repurposing experiments. Although the size of the cities, the type of targeted organic waste varies and local culture differs, the case studies of Thaklong and Pingtung show that the university departments as change agents and the stakeholders as recipients of proposed change face similar opportunities and challenges.","PeriodicalId":40791,"journal":{"name":"Majalah Kedokteran Bandung-MKB-Bandung Medical Journal","volume":"17 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84840246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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