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Correlation between Estrogen Receptorβ (ERβ), Neurofilament Protein (NF), and Protein Gene Product 9.5 (PGP9.5) Expressions as a Marker of Pain on Adenomyosis Etiopathogenesis 雌激素受体β(ERβ)、神经丝蛋白(NF)和蛋白基因产物9.5(PGP9.5)表达作为疼痛标志物在腺肌病发病机制中的相关性
IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2021-12-01 DOI: 10.15395/mkb.v53n4.2363
Arief Setiawan, Ruswana Anwar, Tita Husnitawati, T. Djuwantono, W. Permadi
Adenomyosis is a pathological condition characterized by the presence of endometrial glands and stroma within the myometrium. Endometrial like cells development was influenced by local inflammatory reactions, increases local estradiol due to asynchromatized estrogen synthesis (ERβ) and then stimulated to proliferation and fibrosis, are also irritation on small nerve fibers in women with painful characterized symptoms on adenomyosis. There are expressions of neurofilament protein (NF) and protein gene product 9.5 (PGP 9.5) is a highly specific pan-neuronal marker for microfilament nerve fibers and is related to presenting pain with adenomyosis symptoms. A retrospective immunohistochemical study of thirty samples histopathological of adenomyosis as study groups and 30 with control groups between 25–49 ages which were established at Dr. Hasan Sadikin General Hospital and the satellites in April 2014–May 2015. This case-control analyzed ERβ, NF, and PGP 9.5 expressions compared and correlation between study groups and controls. The results showed there were significant differences in expression of ERβ, NF, and PGP 9.5 on adenomyosis higher than the control study (p<0.05). The intensity was higher and very strong into the study groups (p<0,001). Cut off point of ERβ was more than>6(sensitivity 66.7%; specificity 70%), NF>3 (sensitivity 93%; specificity 46%), PGP 9.5>4 (sensitivity 90%; specificity 67%). Odds Ratio (CI 95%) ERβ>6= 4.67; NF >3=12.25; PGP 9.5 >4=24.75 (p<0.001). The value of histoscore of ERβ and PGP9.5 have correlates to adenomyosis, the differences were statistically significant (p<0.05). The conclusion were that the adenomyosis had higher ERβ, NF, and PGP 9.5 expressions. There are simultant correlates and positive values between ERβ, NF, and PGP9.5 based on etiophatogenesis of pain on adenomyosis.
子宫腺肌病是一种病理性疾病,其特征是子宫肌层内存在子宫内膜腺体和间质。子宫内膜样细胞的发育受到局部炎症反应的影响,由于雌激素合成不同步(ERβ)而增加局部雌二醇,然后刺激增殖和纤维化,也是对子宫腺肌病疼痛症状女性小神经纤维的刺激。神经丝蛋白(NF)和蛋白基因产物9.5(PGP 9.5)的表达是微丝神经纤维的高度特异性泛神经元标志物,与子宫腺肌症症状的疼痛有关。2014年4月至2015年5月,Hasan Sadikin医生综合医院和卫星公司对30个年龄在25-49岁之间的子宫腺肌病组织病理学样本和30个对照组进行了回顾性免疫组织化学研究。该病例对照分析了研究组和对照组之间ERβ、NF和PGP 9.5的表达及其相关性。结果显示,ERβ、NF和PGP 9.5在子宫腺肌病中的表达高于对照研究(p6(敏感性66.7%;特异性70%),NF>3(敏感性93%;特异性46%),PGP 9.5>4(敏感性90%;特异性67%)。比值比(CI 95%)ERβ>6=4.67;NF>3=12.25;ERβ和PGP9.5的组织学评分与子宫腺肌症相关,差异有统计学意义(p<0.05)。ERβ、NF和PGP9.5在子宫腺肌症疼痛发生的基础上存在同时的相关性和正值。
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引用次数: 0
Relationship between Knowledge, Attitude, and Behavior on Head and Neck Cancer among Health Workers and Community in Bandung, Indonesia 印尼万隆市卫生工作者和社区对癌症知识、态度和行为的关系
IF 0.1 Pub Date : 2021-12-01 DOI: 10.15395/mkb.v53n4.2480
Y. A. Dewi, Ifiq Budiyan Nazar
Head and neck cancer is the sixth most common cancer in the world with increasing incidence and mortality in the last three decades. The hidden location of head and neck tumors and their atypical symptoms cause difficulties in diagnosis. Most patients are first diagnosed at an advanced stage. Several factors allegedly related to the incidence of head and neck cancer are knowledge and attitude of the public on early detection of cancer. This study aimed to determine the relationship between knowledge, attitude, and behavior of health workers and community towards head and neck cancer in Bandung, Indonesia. This was a cross-sectional analytical descriptive study using chi-square test as the statistical test. Subjects for this study were sampled using the proportional cluster random sampling on health care workers and community in 30 community health centers in Bandung City during the period of July–August 2019. Data were obtained through a questionnaire distributed to the subjects. This questionnaire included items on knowledge, attitude, and behavior towards head and neck cancer. Of the 650 respondents, most were 40–49 years old (25%), female (62,2%), patients (74%), high school (49%). The levels of knowledge and attitude have a significant relationship with the behavior of early detection of head and neck cancer (p=0.015). The awareness and knowledge of health workers and community on early detection of head and neck cancer are high in Bandung, Indonesia.
头颈癌是世界上第六大常见癌症,在过去三十年中发病率和死亡率不断上升。头颈部肿瘤的隐匿位置和非典型症状给诊断带来困难。大多数患者在晚期才被确诊。据称与头颈癌发病率有关的几个因素是公众对早期发现癌症的知识和态度。本研究旨在确定印度尼西亚万隆卫生工作者和社区对头颈癌的知识、态度和行为之间的关系。本研究为横断面分析描述性研究,采用卡方检验作为统计检验。本研究于2019年7 - 8月对万隆市30个社区卫生中心的医护人员和社区进行比例整群随机抽样。数据是通过分发给受试者的问卷获得的。问卷内容包括对头颈癌的认知、态度和行为。在650名受访者中,大多数为40-49岁(25%),女性(62.2%),患者(74%),高中生(49%)。知识和态度水平与头颈癌早期发现行为有显著关系(p=0.015)。在印度尼西亚万隆,卫生工作者和社区对早期发现头颈癌的认识和知识很高。
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引用次数: 0
FLOTAC Technique for Soil-Transmitted Helminth Infection Diagnosis 土壤传播蠕虫感染诊断的FLOTAC技术
IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2021-12-01 DOI: 10.15395/mkb.v52n4.2545
H. Pangaribuan, T. Supali, H. Wibowo
Human helmintiasis is a neglected disease with significant economic impacts caused by its effects on performance and cognition. The burden of many helminth infections is not well understood due to the lack of progress in detecting low-intensity infection in elimination programs. Furthermore, the decision for individual and community treatments, as well as the community-based control program evaluation, obviously depends on the technics used for parasitological diagnostic. A well-established diagnostic technic will be beneficial to detect and eliminate the disease. Therefore, this study aimed to compare the performance of FLOTAC and FECT technics for detecting helminth infections in human stool. A total of 149 fecal specimens were collected from schoolchildren in Nangapanda village, Ende District, East Nusa Tenggara Province in 2012. The sensitivity of both technics was analyzed using the kappa analysis. Positive results from both technics were used as the gold standard. The sensitivity of FLOTAC for diagnosing T. Trichiura, A. lumbricoides and hookworm infections were 100%, 100%, and 82%, respectively, while the sensitivity of FECT was 80%, 7%, and 18%, respectively. FLOTAC yielded considerably higher mean faecal egg counts (11,452, 1,038, and 19 eggs per gram stool (EPG) for A lumbricoides T. Trichiura , and hookworm). FLOTAC technique was considerably more sensitive than FECT in diagnosing soil-transmitted helminth infections. In conclusion, FLOTAC can be used as a diagnosis tool for future helminth control
人类helmintisis是一种被忽视的疾病,其对表现和认知的影响会对经济产生重大影响。由于在消灭计划中检测低强度感染缺乏进展,许多蠕虫感染的负担尚不清楚。此外,个人和社区治疗的决定,以及社区控制计划的评估,显然取决于用于寄生虫学诊断的技术。一种成熟的诊断技术将有助于检测和消除这种疾病。因此,本研究旨在比较FLOTAC和FECT技术检测人类粪便中蠕虫感染的性能。2012年,共从东努沙登加拉省恩德区Nangapanda村的学童身上采集了149份粪便样本。采用kappa分析法对两种工艺的敏感性进行了分析。两种工艺的阳性结果均作为金标准。FLOTAC诊断鞭虫、蛔虫和钩虫感染的敏感性分别为100%、100%和82%,而FECT诊断鞭虫感染的灵敏度分别为80%、7%和18%。FLOTAC产生了相当高的平均粪蛋数(对于蛔虫、鞭虫和钩虫,每克粪便中有11452、1038和19个蛋)。FLOTAC技术在诊断土壤传播的蠕虫感染方面比FECT敏感得多。总之,FLOTAC可以作为未来蠕虫控制的诊断工具
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引用次数: 0
Accuracy of Urine Cytology In Detecting Bladder Cancer 尿细胞学检测膀胱癌的准确性
IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2021-12-01 DOI: 10.15395/mkb.v53n4.2460
A. Syahreza, Ferry Safriadi
One of the most prevalent and deadly cancers in men is bladder cancer. To achieve the best possible outcome, physicians need to diagnose it promptly. The gold standard for diagnosis is tissue biopsy, but this method is invasive. There is another option for non-invasive diagnostic using urine cytology. The purpose of this study was to measure the accuracy of urine cytology in diagnosed bladder cancer patients. This study extracted data from patients medical records in a tertiary hospital in Indonesia from 2009–2019. The diagnostic accuracy was then compared between urine cytology and biopsy as the gold standard. Data on subjects’ baseline characteristics and diagnostic accuracy (sensitivity, specificity, PPV, and NPV) were collected. Results were then stratified according to the American Joint Committee on Cancer pathology staging for bladder cancer. Of 124 study subjects, male was more dominant (male,88% versus female, 12%) Seventy-five patients had a T1-tumor stage. Overall, the diagnostic accuracy was as follows:sensitivity, 47.8%; specificity, 90.9%; PPV, 98.2%; and NPV, 14.5%. High-grade tumors were shown to have a higher sensitivity. The highest accuracy was found in the MIBC grade T3, which was 90.68%. For diagnostic accuracy, urine cytology offered high specificity, but low sensitivity. The exploration of other markers is needed to establish a non-invasive but accurate method to diagnose bladder cancer.
癌症是男性中最常见和致命的癌症之一。为了达到最好的结果,医生需要及时诊断。诊断的金标准是组织活检,但这种方法是侵入性的。使用尿液细胞学进行非侵入性诊断还有另一种选择。本研究的目的是测量诊断为膀胱癌症患者的尿液细胞学检查的准确性。这项研究从印度尼西亚一家三级医院2009-2019年的患者病历中提取了数据。然后将尿液细胞学和活检的诊断准确性作为金标准进行比较。收集受试者的基线特征和诊断准确性(敏感性、特异性、PPV和NPV)的数据。然后根据美国癌症联合委员会癌症膀胱病理分期对结果进行分层。在124名研究受试者中,男性占主导地位(男性占88%,女性占12%),75名患者为T1肿瘤分期。总体而言,诊断准确率如下:敏感性为47.8%;特异性为90.9%;PPV为98.2%;NPV为14.5%。MIBC T3级的准确率最高,为90.68%。就诊断准确率而言,尿液细胞学提供了高特异性,但敏感性低。需要探索其他标志物,以建立一种非侵入性但准确的方法来诊断癌症。
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引用次数: 0
Agreement on Overt Disseminated Intravascular Coagulation in Sepsis Patients between International Society of Thrombosis and Haemostasis Criteria and Japanese Ministry of Health and Welfare Criteria 国际血栓和止血学会标准与日本卫生和福利部标准对败血症患者明显弥散性血管内凝血的一致
IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2021-12-01 DOI: 10.15395/mkb.v53n4.2398
Dwika Audiyananda, Leni Lismayanti, B. Andriyoko
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引用次数: 0
The End of the Middle East’s Unipolar Era 中东单极时代的终结
IF 0.1 Pub Date : 2021-09-03 DOI: 10.1163/21983534-08020008
S. Mousavian, S. Ameri
This Policy Insight article argues that a growing security partnership between Russia, Iran, China, Turkey, Iraq, and Syria (rictis) will push the Middle East into an era of bipolarity. The paper demonstrates that rictis has significant convergence on regional security issues, and that these interests are distinct from those held by the American Security Camp, a collection of states that include the United States, Saudi Arabia, Israel, and the United Arab Emirates. The paper also argues that rictis has military and energy advantages that allow it to confront the American Camp’s regional dominance. Our analysis demonstrates how rictis might help deter unilateralism and democratize regional decision-making.
这篇政策洞察文章认为,俄罗斯、伊朗、中国、土耳其、伊拉克和叙利亚之间日益增长的安全伙伴关系将把中东推向一个两极时代。本文表明,rictis在地区安全问题上有显著的趋同,这些利益与美国安全阵营(包括美国、沙特阿拉伯、以色列和阿拉伯联合酋长国等国家的集合)所持有的利益不同。文章还认为,中国拥有军事和能源优势,可以对抗美国阵营的地区主导地位。我们的分析表明,rictis可能有助于阻止单边主义和民主化区域决策。
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引用次数: 0
Governance by Perpetual Conflict: How Early Colonial Political Practices Undermine Democracy in Post-Civil War Sri Lanka 长期冲突的治理:早期殖民政治实践如何破坏内战后斯里兰卡的民主
IF 0.1 Pub Date : 2021-09-03 DOI: 10.1163/21983534-08020002
B. Perera
The 1978 Constitution of Sri Lanka established a semi-presidential system within the country with constitutional provisions for a powerful executive presidency. Three decades later, practices of the presidents in the post-war period show commonalities with the Sinhala monarchy that prevailed in early colonial Sri Lanka. To substantiate this argument, this paper focuses on four kings from the Sithavaka and Kandyan kingdoms who reigned in Sri Lanka during the Portuguese colonization and the early years of Dutch colonization, i.e. from 1521 to 1687. These kings governed by feeding off perpetual conflict, using such as a political tool to retain their dictatorial authority and political relevance. Despite being formally constrained by the 1978 Constitution, presidents in the post-war period engage in a similar form of governance. However, this local conceptualization of the executive as a monarch clashes with the substantive democratic rationality of the office of president, which requires constitutional and political checks that apply beyond elections. Due to this clash between governance by perpetual conflict, which gains legitimacy from and has been instituted since Sri Lanka’s early colonial past, and democratic governance, the establishment of democratic constitutional norms within the country has been unstable.
1978年的斯里兰卡宪法确立了该国的半总统制,宪法规定了一个强大的执行总统。三十年后,战后总统的做法显示出与早期殖民斯里兰卡盛行的僧伽罗君主制的共同点。为了证实这一论点,本文将重点放在葡萄牙殖民时期和荷兰殖民初期(即1521年至1687年)统治斯里兰卡的Sithavaka和Kandyan王国的四位国王身上。这些国王通过不断的冲突来进行统治,利用这种政治工具来保持他们的独裁权威和政治相关性。尽管受到1978年宪法的正式约束,但战后时期的总统也采取了类似的治理形式。然而,这种将行政机构视为君主的地方性概念与总统办公室的实质性民主合理性相冲突,后者需要适用于选举之外的宪法和政治检查。由于长期冲突的治理与民主治理之间的冲突,这种冲突从斯里兰卡早期的殖民历史中获得合法性并已建立,在该国建立民主宪法规范一直不稳定。
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引用次数: 0
China’s Humanistic Zhong-Yong Approach to Educational Partnerships for International Development in Post-Covid-19: Confucian and Ubuntu Perspectives on Confucius Institutes and Classrooms in Africa 新冠肺炎疫情后,中国人文主义的“中勇”国际教育合作:非洲孔子学院和孔子课堂的儒家与乌班图视角
IF 0.1 Pub Date : 2021-09-03 DOI: 10.1163/21983534-08020006
Jun Li
Based on broad observations of the development of Confucius Institutes and Classrooms in Africa over a decade, this article focuses on educational partnerships between Chinese and African educational institutions and their implications for international development, as they relate to international development in the era of post-Covid-19. The author identifies the Confucian Zhong-Yong approach to educational partnerships through Confucius Institutes and Classrooms in Africa, a pragmatic model for educational development centered on Confucianism. Three core characteristics of Confucian educational partnerships – demand-driven, ethics-based and pragmatic – are seen as the key to the success of such partnerships. Reflecting on Ubuntu from a Confucian perspective, the author concludes that China’s humanistic Zhong-Yong approach to partnerships has a unique potential to re-envision education for international development in ways that may be of interest to such international developmental agencies as the Asian Infrastructure Investment Bank, the World Bank, and the United Nations.
本文基于对非洲孔子学院和孔子课堂十多年发展的广泛观察,重点关注中非教育机构之间的教育伙伴关系及其对国际发展的影响,因为它们关系到后新冠肺炎时代的国际发展。作者在非洲通过孔子学院和孔子课堂确定了儒家的中庸方法,这是一种以儒家思想为中心的教育发展的务实模式。儒家教育伙伴关系的三个核心特征——需求驱动、伦理为基础和务实——被视为这种伙伴关系成功的关键。从儒家的角度反思乌班图,作者得出结论,中国人文主义的中庸合作方式具有独特的潜力,可以以亚洲基础设施投资银行、世界银行和联合国等国际发展机构感兴趣的方式重新构想国际发展教育。
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引用次数: 1
Varieties of Clientelism in Comparative Democracies: Power, State Formation and Citizenship in the Philippines, Bosnia and Herzegovina 比较民主中的庇护主义的多样性:权力、国家形成和公民身份在菲律宾、波斯尼亚和黑塞哥维那
IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2021-09-03 DOI: 10.1163/21983534-08020005
Cleo Calimbahin
Clientelism in comparative democracies have evolved through time within informal and formal institutions. Using the book by Brkovic, that follows the tradition of challenging the unidimensional view of clientelism in Bosnia and Herzegovina, this essay provides the Philippine case as contrast and comparison. The article examines how both countries’ experience can open new avenues for us to understand the durability of clientelism and its relationship with formal and informal institutions. Brokovic’s agency and personhood within clientelistic relationships accounts for the endurance of this practice in democratic societies that experienced transition. Clientelism persists in part due to the reliability of personal relations over the ability of public institutions to deliver. This review article will probe clientelism, as it manifests in the politics of the Philippines and its democratic institutions. Among the multiple types of clientelistic relationship in the Philippines, some emphasize the role of machine politics, corruption, and coercion. Brković’s book provides a new lens of analysis by looking at clientelism through personhood and agency as power. The contribution of the book on the discourse of clientelism can deepen the understanding of Philippine politics because it encourages an analysis that looks at the exercise of democracy through personhood, agency, and informal institutions. It invites us to view clientelism not just through corruption and violence. By combining the analysis that utilizes formal and informal institutions, personhood and structuralist, this essay explains why some countries that have transitioned into democracies remain ambiguous states and explain the persistence of clientelism.
相对民主国家的庇护主义在非正式和正式机构中随着时间的推移而演变。布尔科维奇的书沿袭了传统,对波斯尼亚和黑塞哥维那的裙带主义的单一性观点提出了挑战,本文以菲律宾为例进行对比和比较。本文考察了两国的经验如何为我们理解裙带关系的持久性及其与正式和非正式机构的关系开辟了新的途径。Brokovic在代理关系中的代理和人格解释了这种做法在经历转型的民主社会中的持久性。裙带关系之所以持续存在,部分原因在于私人关系的可靠性高于公共机构提供服务的能力。这篇评论文章将探讨庇护主义,因为它体现在菲律宾的政治和民主制度中。在菲律宾多种类型的裙带关系中,有些强调机器政治、腐败和胁迫的作用。布尔科维奇的书提供了一个新的分析视角,通过人格和代理作为权力来看待裙带主义。这本书对庇护主义话语的贡献可以加深对菲律宾政治的理解,因为它鼓励通过人格、代理和非正式机构来分析民主的行使。它让我们审视裙带关系,而不仅仅是腐败和暴力。通过结合运用正式和非正式制度、人格和结构主义的分析,本文解释了为什么一些过渡到民主国家仍然是模棱两可的国家,并解释了庇护主义的持续存在。
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引用次数: 0
The Paulo Freire System 保罗·弗莱雷系统
IF 0.1 Pub Date : 2021-09-03 DOI: 10.1163/21983534-08020007
C. Torres
This article discusses the origins and structure of what for the lack of a better term I will call the ‘Paulo Freire System’. Focusing on the historical experience of Angicos which catapulted Freire to world fame as an adult educator, a major claim of this article is that Freire’s work was a much more ambitious and revolutionary project than transforming adult education and literacy training becoming another landmark in the history of popular education in the region. The Angicos experience connecting public education with popular culture, the system that Freire and associates imagined in the sixties aimed for a profound and revolutionary transformation of public education in Brazil. With his exile in 1964, popular education becomes a model that could deeply affect public education worldwide. Represented theoretically in the pages of Pedagogy of the Oppressed, a pedagogical classic of the twenty first century, education is for Freire critical hermeneutics, addressing the dilemmas of citizenship building with a postcolonial ethics.
本文讨论了“保罗·弗莱雷系统”的起源和结构,因为没有更好的术语,我将称之为“保罗·弗莱雷系统”。这篇文章的主要观点是,弗莱雷的工作是一个更雄心勃勃和革命性的项目,而不是将成人教育和扫盲培训转变为该地区大众教育史上的另一个里程碑。Angicos的经验将公共教育与流行文化联系起来,Freire和同事在60年代设想的系统旨在对巴西的公共教育进行深刻而革命性的转变。随着1964年他的流亡,大众教育成为了深刻影响世界公共教育的典范。在《被压迫者的教育学》这本21世纪的经典教学著作中,教育是弗雷尔批判解释学的理论代表,用后殖民伦理来解决公民建设的困境。
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引用次数: 2
期刊
Majalah Kedokteran Bandung-MKB-Bandung Medical Journal
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