{"title":"Active Surveillance in Prostate Cancer","authors":"V. Izol, N. Akdoğan","doi":"10.4274/uob.820","DOIUrl":"https://doi.org/10.4274/uob.820","url":null,"abstract":"","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":"16 1","pages":"127-132"},"PeriodicalIF":0.2,"publicationDate":"2017-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49274827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Beksac, M. Dönmez, Ç. Aydın, D. Baydar, M. Yazıcı, A. Ergen, B. Akdogan
Persistent Müllerian duct syndrome (PMDS) is defined as the presence of Müllerian remnants in a phenotypically and karyotypically male (1). PMDS is caused either by the lack of anti-Müllerian hormone, receptor insensitivity or a defect in the timing of the release of Müllerian inhibiting factor (MIF). PMDS is regarded as a form of pseudohermaphroditism due to presence of uterus and is shown to be inherited autosomal recessively (2). Although it is predominantly seen in pediatric age group presenting as undescended testis with or without inguinal hernia, it might be presented as an inguinal or intraabdominal mass in adulthood (3). Herein we report 2 cases of PMDS with review of the literature. Case Presentations
{"title":"A Rare Presentation of Germ Cell Neoplasia: Persistant Müllerian Duct Syndrome","authors":"A. Beksac, M. Dönmez, Ç. Aydın, D. Baydar, M. Yazıcı, A. Ergen, B. Akdogan","doi":"10.4274/UOB.825","DOIUrl":"https://doi.org/10.4274/UOB.825","url":null,"abstract":"Persistent Müllerian duct syndrome (PMDS) is defined as the presence of Müllerian remnants in a phenotypically and karyotypically male (1). PMDS is caused either by the lack of anti-Müllerian hormone, receptor insensitivity or a defect in the timing of the release of Müllerian inhibiting factor (MIF). PMDS is regarded as a form of pseudohermaphroditism due to presence of uterus and is shown to be inherited autosomal recessively (2). Although it is predominantly seen in pediatric age group presenting as undescended testis with or without inguinal hernia, it might be presented as an inguinal or intraabdominal mass in adulthood (3). Herein we report 2 cases of PMDS with review of the literature. Case Presentations","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":"16 1","pages":"101-104"},"PeriodicalIF":0.2,"publicationDate":"2017-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47902449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Koparal, C. Acar, Betul Ogut, E. Tokat, Fatih Bicaklioglu, I. Gönül, A. Batur, T. Sözen
{"title":"Do Length and Tumor Grades of Positive Surgical Margin Have an Impact on Biochemical Recurrence After Prostatectomy","authors":"M. Koparal, C. Acar, Betul Ogut, E. Tokat, Fatih Bicaklioglu, I. Gönül, A. Batur, T. Sözen","doi":"10.4274/UOB.859","DOIUrl":"https://doi.org/10.4274/UOB.859","url":null,"abstract":"","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":"16 1","pages":"86-91"},"PeriodicalIF":0.2,"publicationDate":"2017-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48622242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effect of Sex and Age Differences on Pathology Results in Primary Bladder Cancer Patients","authors":"H. Türk, Sıtkı Ün, Batuhan Ergani","doi":"10.4274/uob.857","DOIUrl":"https://doi.org/10.4274/uob.857","url":null,"abstract":"","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":"16 1","pages":"81-85"},"PeriodicalIF":0.2,"publicationDate":"2017-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47986569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relationship Between Human Papilloma Virus and Bladder Cancer","authors":"O. Inci, E. Taştekin, H. Akdere","doi":"10.4274/UOB.556","DOIUrl":"https://doi.org/10.4274/UOB.556","url":null,"abstract":"","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":"16 1","pages":"92-94"},"PeriodicalIF":0.2,"publicationDate":"2017-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46984735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"What are the New Developments in Urinary, Serum and Tissue Biomarkers in Prostate Cancer?","authors":"H. Şahin, M. Çetinkaya, H. Deliktaş","doi":"10.4274/uob.620","DOIUrl":"https://doi.org/10.4274/uob.620","url":null,"abstract":"","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":"43 1","pages":"95-100"},"PeriodicalIF":0.2,"publicationDate":"2017-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70977338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primary Adrenal Lymphoma: A Case Report","authors":"I. Kazaz, Ayhan Arslan, Nergiz Erkut, O. Kutlu","doi":"10.4274/uob.876","DOIUrl":"https://doi.org/10.4274/uob.876","url":null,"abstract":"","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":"16 1","pages":"105-107"},"PeriodicalIF":0.2,"publicationDate":"2017-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49029673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zeliha Ertürk, Esra Büber, H. Özen, Ö. Çelikbıçak, B. Salih, N. Acan
Amaç: Lokal ve sistemik yan etkilerine rağmen, yüksek riskli kasa invaziv olmayan mesane kanserinde (KİOMK) Bacillus Calmette-Guérin (BCG) uygulanması altın standart tedavidir. Biz mesane kanseri tedavisi için canlı suşlar yerine daha az toksik ve daha güçlü terapötik ajanlar geliştirmeyi hedefledik. Gereç ve Yöntem: İmmünostimülan ve sitotoksik aktiviteleri BCG ile benzerlik gösteren patojen olmayan Mycobacterium brumae suşu kullanıldı. Bakteriler ısı muamelesinden sonra sonike edildi. Sulu çözeltiyle ve asetonla ekstre edilerek hazırlanmış örnekler ters faz ve kuvvetli iyon değiştirici kolonlar kullanılarak yüksek performanslı sıvı kromatografisi uygulandı. Örneklerin tümör nekroz faktörü-α (TNF-α) uyarıcı aktiviteleri ve matriks-yardımlı lazer desorpsiyon-iyonlaştırmalı-kütle spektrometri çıktıları incelendi. Bulgular: Sonuç olarak, m/z oranları 1800 ve 3600 dolayındaki iki bileşenin TNF-α uyarıcı aktiviteden sorumlu olabileceği ortaya çıkarıldı. Sonuç: Bu bileşenler KİOMK tedavisi için yeni ajanlar geliştirme potansiyeline sahiptir. Anahtar Kelimeler: Mycobacterium brumae, kasa invaziv olmayan mesane kanseri, yüksek performanslı sıvı kromatografisi, matriks-yardımlı lazer desorpsiyon-iyonlaştırmalı kütle spektrometri, tümör nekroz faktörü-α Objective: Immunotherapy with intravesical Bacillus Calmette-Guérin (BCG) application is a gold standard treatment for high risk non-muscle invasive bladder cancer (NMIBC), despite its local and systemic side effects. We aimed to develop less toxic and more powerful therapeutic agents for the treatment of bladder cancer than live strain. Materials and Methods: Non-pathogenic Mycobacterium brumae strains resembling BCG in immunostimulating and cytotoxic activities were used. The bacteria were sonicated after heat treatment. Samples prepared by aqueous solution and acetone were subjected to high performance liquid chromatography on reverse phase and strong ion exchange columns. Tumour necrosis factor-α (TNF-α) stimulating activities and the matrixassisted laser desorption/ionization-mass spectroscopy findings of the samples were analysed. Results: As a result, it was revealed that two components, m/z ratios around 1800 and another around m/z 3600 could be responsible for TNF-α stimulating activity. Conclusion: These components have a potential to develop of new agents for NMIBC treatment.
目的是将卡氏杆菌（BCG）应用于非高危储存癌症的金标准治疗，尽管存在局部和全身副作用。我们的目标是开发毒性更小、更强的治疗剂，而不是癌症治疗的活水。Gereçve Yöntem：Il mmünostimülan ve sitotoksik aktiviteleri BCG ile benzerlik gösteren patojen olmayan分枝杆菌brumae suşu kullanıldı。细菌经过热处理后就消失了。高效液相色谱法已应用于反相离子交换柱和强力离子交换柱的水分辨率和asetone提取样品。研究了肿瘤坏死因子α（TNF-α）预警活性和基质辅助激光解吸电离质谱的实例。事件：因此，1800至3600之间的两种成分被证明是TNF-α警告活性的原因。结果：这些成分有能力开发用于KIOMK治疗的新药物。关键词：布鲁马分枝杆菌、无创性美沙拉烷癌症、高效液相色谱法、基质辅助激光解吸电离质谱法、肿瘤坏死因子-α，尽管它有局部和系统的副作用。我们的目标是开发比活菌株毒性更小、更强大的治疗剂来治疗膀胱癌症。材料和方法：使用具有类似BCG的免疫刺激和细胞毒性活性的非致病性布鲁马分枝杆菌菌株。热处理后对细菌进行超声处理。用水溶液和丙酮制备的样品在反相和强离子交换柱上进行高效液相色谱。分析了样品的肿瘤坏死因子-α（TNF-α）刺激活性和基质辅助激光解吸/电离质谱结果。结果：两组分，m/z比值在1800左右和m/z比值约在3600左右，可能对TNF-α的刺激活性起作用。结论：这些成分具有开发新的NMIBC治疗药物的潜力。
{"title":"Mycobacterium Brumae Extract Fractions with Potential Immunotherapeutic Activity for Bladder Cancer","authors":"Zeliha Ertürk, Esra Büber, H. Özen, Ö. Çelikbıçak, B. Salih, N. Acan","doi":"10.4274/UOB.905","DOIUrl":"https://doi.org/10.4274/UOB.905","url":null,"abstract":"Amaç: Lokal ve sistemik yan etkilerine rağmen, yüksek riskli kasa invaziv olmayan mesane kanserinde (KİOMK) Bacillus Calmette-Guérin (BCG) uygulanması altın standart tedavidir. Biz mesane kanseri tedavisi için canlı suşlar yerine daha az toksik ve daha güçlü terapötik ajanlar geliştirmeyi hedefledik. Gereç ve Yöntem: İmmünostimülan ve sitotoksik aktiviteleri BCG ile benzerlik gösteren patojen olmayan Mycobacterium brumae suşu kullanıldı. Bakteriler ısı muamelesinden sonra sonike edildi. Sulu çözeltiyle ve asetonla ekstre edilerek hazırlanmış örnekler ters faz ve kuvvetli iyon değiştirici kolonlar kullanılarak yüksek performanslı sıvı kromatografisi uygulandı. Örneklerin tümör nekroz faktörü-α (TNF-α) uyarıcı aktiviteleri ve matriks-yardımlı lazer desorpsiyon-iyonlaştırmalı-kütle spektrometri çıktıları incelendi. Bulgular: Sonuç olarak, m/z oranları 1800 ve 3600 dolayındaki iki bileşenin TNF-α uyarıcı aktiviteden sorumlu olabileceği ortaya çıkarıldı. Sonuç: Bu bileşenler KİOMK tedavisi için yeni ajanlar geliştirme potansiyeline sahiptir. Anahtar Kelimeler: Mycobacterium brumae, kasa invaziv olmayan mesane kanseri, yüksek performanslı sıvı kromatografisi, matriks-yardımlı lazer desorpsiyon-iyonlaştırmalı kütle spektrometri, tümör nekroz faktörü-α Objective: Immunotherapy with intravesical Bacillus Calmette-Guérin (BCG) application is a gold standard treatment for high risk non-muscle invasive bladder cancer (NMIBC), despite its local and systemic side effects. We aimed to develop less toxic and more powerful therapeutic agents for the treatment of bladder cancer than live strain. Materials and Methods: Non-pathogenic Mycobacterium brumae strains resembling BCG in immunostimulating and cytotoxic activities were used. The bacteria were sonicated after heat treatment. Samples prepared by aqueous solution and acetone were subjected to high performance liquid chromatography on reverse phase and strong ion exchange columns. Tumour necrosis factor-α (TNF-α) stimulating activities and the matrixassisted laser desorption/ionization-mass spectroscopy findings of the samples were analysed. Results: As a result, it was revealed that two components, m/z ratios around 1800 and another around m/z 3600 could be responsible for TNF-α stimulating activity. Conclusion: These components have a potential to develop of new agents for NMIBC treatment.","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":"16 1","pages":"70-76"},"PeriodicalIF":0.2,"publicationDate":"2017-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47606928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of Imaging in Testicular Cancer Diagnosis, Staging and Follow-up","authors":"N. Voyvoda, Bekir Voyvoda, Özden Çamurdan","doi":"10.4274/UOB.694","DOIUrl":"https://doi.org/10.4274/UOB.694","url":null,"abstract":"","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":"16 1","pages":"51-56"},"PeriodicalIF":0.2,"publicationDate":"2017-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48751041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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