Behzad Jafarinia, R. Rashti, L. Mohebbi, Javad Moazen, Elham Kord
Background: Schistosomiasis, after malaria, is the second most important parasitic disease in the world in terms of morbidity and mortality and is one of the 14 neglected tropical diseases. In 2016, about 206.4 million people needed preventive treatment for the disease. Objectives: This study evaluated schistosomiasis’s incidence rate and spatial-temporal cluster distribution in the north of Khuzestan province, Iran. Methods: This cross-sectional study collected data from January 1977 to December 2001. The data of 1,390 definitive patients with Schistosoma haematobium in the north of Khuzestan province, Iran, were analyzed for the disease incidence in rural districts over five-year periods. Also, the changes in median age and sex were examined. Spatial scan statistics were used to diagnose and evaluate the spatial clusters of S. haematobium cases. The pure retrospective temporal analysis and retrospective spatial-temporal analysis were carried out to identify the temporal clusters and spatial-temporal clusters of schistosomiasis with high rates, respectively, using the discrete Poisson model. Results: The schistosomiasis incidence decreased over the years, with the last case reported in 2001. Using Kulldorff’s spatial scan method, spatial clustering showed nine high-risk areas in the north of Khuzestan province from 1977 to 2001. Besides, S. haematobium was not randomly distributed in this area. Spatial-temporal clusters identified three high-risk areas during the study period. Temporal clusters decreased from 17 months and five days to one day, and they mainly occurred in the winter and summer. Conclusions: The study indicated a zero incidence and vanishing S. haematobium endemicity in the northern region of Khuzestan province of Iran in 2002. Due to snail vectors of the disease resident in this region, the disease surveillance still needs continuation.
{"title":"Vanishing Schistosomiasis Endemicity in North of Khuzestan Province, Iran: A Twenty-Five-Year Assessment","authors":"Behzad Jafarinia, R. Rashti, L. Mohebbi, Javad Moazen, Elham Kord","doi":"10.5812/tms-118034","DOIUrl":"https://doi.org/10.5812/tms-118034","url":null,"abstract":"Background: Schistosomiasis, after malaria, is the second most important parasitic disease in the world in terms of morbidity and mortality and is one of the 14 neglected tropical diseases. In 2016, about 206.4 million people needed preventive treatment for the disease. Objectives: This study evaluated schistosomiasis’s incidence rate and spatial-temporal cluster distribution in the north of Khuzestan province, Iran. Methods: This cross-sectional study collected data from January 1977 to December 2001. The data of 1,390 definitive patients with Schistosoma haematobium in the north of Khuzestan province, Iran, were analyzed for the disease incidence in rural districts over five-year periods. Also, the changes in median age and sex were examined. Spatial scan statistics were used to diagnose and evaluate the spatial clusters of S. haematobium cases. The pure retrospective temporal analysis and retrospective spatial-temporal analysis were carried out to identify the temporal clusters and spatial-temporal clusters of schistosomiasis with high rates, respectively, using the discrete Poisson model. Results: The schistosomiasis incidence decreased over the years, with the last case reported in 2001. Using Kulldorff’s spatial scan method, spatial clustering showed nine high-risk areas in the north of Khuzestan province from 1977 to 2001. Besides, S. haematobium was not randomly distributed in this area. Spatial-temporal clusters identified three high-risk areas during the study period. Temporal clusters decreased from 17 months and five days to one day, and they mainly occurred in the winter and summer. Conclusions: The study indicated a zero incidence and vanishing S. haematobium endemicity in the northern region of Khuzestan province of Iran in 2002. Due to snail vectors of the disease resident in this region, the disease surveillance still needs continuation.","PeriodicalId":408913,"journal":{"name":"Trends in Medical Sciences","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126303317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Heart failure (HF) is recognized as a structural and functional heart complication. Many studies have revealed that anemia plays an ambiguous role in this complication and can be a significant prognostic parameter in HF. In our trial, for clarification of this issue, the relationship between HF and anemia was studied. Methods: In this case-control study, 273 patients admitted to the CCU and post-CCU wards of Dezful Hospital, who were selected by the available sampling method, were studied. In this investigation, among 273 patients with HF, hematological, biochemical, and heart functional parameters were assessed and compared with 89 healthy volunteers. Consequently, the correlation between hematological parameters and functional heart parameters in the patients was evaluated via Pearson’s correlation coefficient. Results: The study subjects were tried to have similar conditions regarding their demographic characteristics. The mean age of the included participants was 53.68 ± 2.17 years. Our data revealed that HF occurs mainly at the age of 50 to 70 years, and patients had an 8.7% mortality risk. Hematocrit (HCT) had a significant reduction in the HF group in comparison to the normal range (P-value < 0.05), and HCT level in healthy subjects (P-value 0.02). Further, anemia is positively correlated with HF mortality rate and severity of HF indices in patients (P-value = 0.01). Conclusions: The results of our study, consistent with other previous studies, showed that HF patients have a low HCT level, and this reduction is associated with a marked decline in health status indices in HF patients. Also, our results revealed that patients with the lowest level of HCT are at high risk for HF symptoms.
{"title":"Consequences of Anemia in Patients with Chronic Heart Failure","authors":"Shima Yazdanfar, Neda Shakerian, Mohammad Reza Atabi, Azam Sadeghiniya, Maysam Mard-Soltani","doi":"10.5812/tms-3598","DOIUrl":"https://doi.org/10.5812/tms-3598","url":null,"abstract":"Background: Heart failure (HF) is recognized as a structural and functional heart complication. Many studies have revealed that anemia plays an ambiguous role in this complication and can be a significant prognostic parameter in HF. In our trial, for clarification of this issue, the relationship between HF and anemia was studied. Methods: In this case-control study, 273 patients admitted to the CCU and post-CCU wards of Dezful Hospital, who were selected by the available sampling method, were studied. In this investigation, among 273 patients with HF, hematological, biochemical, and heart functional parameters were assessed and compared with 89 healthy volunteers. Consequently, the correlation between hematological parameters and functional heart parameters in the patients was evaluated via Pearson’s correlation coefficient. Results: The study subjects were tried to have similar conditions regarding their demographic characteristics. The mean age of the included participants was 53.68 ± 2.17 years. Our data revealed that HF occurs mainly at the age of 50 to 70 years, and patients had an 8.7% mortality risk. Hematocrit (HCT) had a significant reduction in the HF group in comparison to the normal range (P-value < 0.05), and HCT level in healthy subjects (P-value 0.02). Further, anemia is positively correlated with HF mortality rate and severity of HF indices in patients (P-value = 0.01). Conclusions: The results of our study, consistent with other previous studies, showed that HF patients have a low HCT level, and this reduction is associated with a marked decline in health status indices in HF patients. Also, our results revealed that patients with the lowest level of HCT are at high risk for HF symptoms.","PeriodicalId":408913,"journal":{"name":"Trends in Medical Sciences","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126190170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pouya Safarzadeh Kozani, Seyed Mohamad Javad Mirarefin, Sara Sheikhi, Narges Baharifar, Mehdi Sheikhi, Nasir Shams, Mojtaba Nikbakht, A. Sheikhi
{"title":"COVID-19 Vaccines in Iran","authors":"Pouya Safarzadeh Kozani, Seyed Mohamad Javad Mirarefin, Sara Sheikhi, Narges Baharifar, Mehdi Sheikhi, Nasir Shams, Mojtaba Nikbakht, A. Sheikhi","doi":"10.5812/tms-127067","DOIUrl":"https://doi.org/10.5812/tms-127067","url":null,"abstract":"<jats:p />","PeriodicalId":408913,"journal":{"name":"Trends in Medical Sciences","volume":"16 14","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133203788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pouya Safarzadeh Kozani, Narges Baharifar, Mehdi Sheikhi, Fatemeh Kiani, Forough Chamaie Nejad, Seyed Mohamad Javad Mirarefin, A. Sheikhi
{"title":"COVID-19 Treatment and Management: Two Years After the Outbreak","authors":"Pouya Safarzadeh Kozani, Narges Baharifar, Mehdi Sheikhi, Fatemeh Kiani, Forough Chamaie Nejad, Seyed Mohamad Javad Mirarefin, A. Sheikhi","doi":"10.5812/tms-127016","DOIUrl":"https://doi.org/10.5812/tms-127016","url":null,"abstract":"<jats:p />","PeriodicalId":408913,"journal":{"name":"Trends in Medical Sciences","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121662192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Preeclampsia is one of the complications of pregnancy that endangers the life of the mother and the fetus. This complication accounts for 18% of maternal mortality and is the second leading cause of maternal mortality in Iran. Various studies have shown the important role of platelets in the pathogenesis of preeclampsia. Objectives: This study was conducted to evaluate platelet parameters in patients with preeclampsia compared to healthy pregnant women who were referred to Ganjavian hospital in Dezful city in 2019. Methods: In this study, which is a retrospective case-control study, the files of women who gave birth in Ganjavian hospital in 2019 were examined. The files of the case group, which included people with preeclampsia, were selected as available samples (104 people), and the control group, which included pregnant women without preeclampsia, were randomly selected using a table of random numbers (104 cases). Criteria for entering the study in the group with preeclampsia included BP ≥ 140/90 mmHg, proteinuria of more than 300 mg in 24-hour urine or 30 mg consistently in random urine samples, and gestational age over 20 weeks. Also, people with any underlying disease, such as diabetes, chronic hypertension, known platelet disorders, multiple birth, and drug use (heparin, aspirin) in the group with preeclampsia were excluded from the study. The data of this study were analyzed using SPSS software version 20, and independent t-test, and Mann-Whitney U test at a significant level lower than 0.05. Results: There was no statistically significant difference in demographic factors between the two case and control groups. There was a statistically significant difference between the mean hemoglobin in healthy women 11.91 ± 1.30 and preeclampsia 10.89 ± 1.09 (P < 0.0001). Also, according to the findings, the individuals of the two groups had a significant difference in terms of mean platelet volume (MPV): healthy women: 10.79 ± 1.24 and preeclampsia women: 12.98 ± 1.16 (P < 0.0001). Also, the results of the Mann-Whitney U test showed that there was a statistically significant difference between the number of platelets in healthy women (284.52 ± 60.58 mm3) and preeclampsia women (149.30 ± 30.38 mm3) (P < 0.0001). Conclusions: Considering the importance of reducing the complications and mortality of pregnant mothers, early detection of changes in platelet factors during pregnancy can be a predictive factor in identifying people at risk for preeclampsia.
{"title":"Evaluation of Platelet Parameters in Patients with Preeclampsia in Comparison with Healthy Pregnant Women Referring to Ganjavian Hospital in Dezful City in 2019","authors":"Nastaran Mirsamiyazdi, Mahnaz Nosratabadi, Leila Masoudiyekta, Radman Amiri, Fahimeh Papi ahmadi, H. Bahrami","doi":"10.5812/tms-121181","DOIUrl":"https://doi.org/10.5812/tms-121181","url":null,"abstract":"Background: Preeclampsia is one of the complications of pregnancy that endangers the life of the mother and the fetus. This complication accounts for 18% of maternal mortality and is the second leading cause of maternal mortality in Iran. Various studies have shown the important role of platelets in the pathogenesis of preeclampsia. Objectives: This study was conducted to evaluate platelet parameters in patients with preeclampsia compared to healthy pregnant women who were referred to Ganjavian hospital in Dezful city in 2019. Methods: In this study, which is a retrospective case-control study, the files of women who gave birth in Ganjavian hospital in 2019 were examined. The files of the case group, which included people with preeclampsia, were selected as available samples (104 people), and the control group, which included pregnant women without preeclampsia, were randomly selected using a table of random numbers (104 cases). Criteria for entering the study in the group with preeclampsia included BP ≥ 140/90 mmHg, proteinuria of more than 300 mg in 24-hour urine or 30 mg consistently in random urine samples, and gestational age over 20 weeks. Also, people with any underlying disease, such as diabetes, chronic hypertension, known platelet disorders, multiple birth, and drug use (heparin, aspirin) in the group with preeclampsia were excluded from the study. The data of this study were analyzed using SPSS software version 20, and independent t-test, and Mann-Whitney U test at a significant level lower than 0.05. Results: There was no statistically significant difference in demographic factors between the two case and control groups. There was a statistically significant difference between the mean hemoglobin in healthy women 11.91 ± 1.30 and preeclampsia 10.89 ± 1.09 (P < 0.0001). Also, according to the findings, the individuals of the two groups had a significant difference in terms of mean platelet volume (MPV): healthy women: 10.79 ± 1.24 and preeclampsia women: 12.98 ± 1.16 (P < 0.0001). Also, the results of the Mann-Whitney U test showed that there was a statistically significant difference between the number of platelets in healthy women (284.52 ± 60.58 mm3) and preeclampsia women (149.30 ± 30.38 mm3) (P < 0.0001). Conclusions: Considering the importance of reducing the complications and mortality of pregnant mothers, early detection of changes in platelet factors during pregnancy can be a predictive factor in identifying people at risk for preeclampsia.","PeriodicalId":408913,"journal":{"name":"Trends in Medical Sciences","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122279623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shahzad Mehranfard, Ferdos Pelarak, R. Kousari, Leila Kalani
Background: An important challenge for universities and research managers is to motivate faculty members to carry out research and increase the number of articles, which increases the university’s research ranking. The first stage in organizing research in the community is the achievement of a correct understanding of the capabilities and available facilities and realizing the weaknesses and strengths of research programs. Objectives: This study was conducted to investigate the barriers to research from the perspective of the faculty members of Dezful University of Medical Sciences, Khuzestan, Iran. Methods: This descriptive-analytical cross-sectional study was performed to determine the barriers to research from the perspective of the faculty members of Dezful University of Medical Sciences. The data collection tool was a questionnaire consisting of two personal information sections and a questionnaire containing 39 items in four domains. The SPSS software (version 21), independent t-test, and analysis of variance were used to analyze the data. Results: The mean age of the participants was 26.9 ± 7.43 years. Additionally, 25 (50%) and 25 (50%) subjects were male and female. Moreover, 34 (68%), 13 (23%), and 3 (6%) participants were working in the Medical School, Nursing School, and Paramedical School, respectively. Conclusions: From the perspective of the faculty members, there were several barriers to research activities, the most important of which was related to the individual domain and financial support for the researcher. Furthermore, the specification of the research process by eliminating cumbersome administrative rules and creating a balance between obligatory hours dedicated to research and education can be an effective stage in the process of performing research activities.
{"title":"How Can Faculty Members Produce More Articles?","authors":"Shahzad Mehranfard, Ferdos Pelarak, R. Kousari, Leila Kalani","doi":"10.5812/tms-123315","DOIUrl":"https://doi.org/10.5812/tms-123315","url":null,"abstract":"Background: An important challenge for universities and research managers is to motivate faculty members to carry out research and increase the number of articles, which increases the university’s research ranking. The first stage in organizing research in the community is the achievement of a correct understanding of the capabilities and available facilities and realizing the weaknesses and strengths of research programs. Objectives: This study was conducted to investigate the barriers to research from the perspective of the faculty members of Dezful University of Medical Sciences, Khuzestan, Iran. Methods: This descriptive-analytical cross-sectional study was performed to determine the barriers to research from the perspective of the faculty members of Dezful University of Medical Sciences. The data collection tool was a questionnaire consisting of two personal information sections and a questionnaire containing 39 items in four domains. The SPSS software (version 21), independent t-test, and analysis of variance were used to analyze the data. Results: The mean age of the participants was 26.9 ± 7.43 years. Additionally, 25 (50%) and 25 (50%) subjects were male and female. Moreover, 34 (68%), 13 (23%), and 3 (6%) participants were working in the Medical School, Nursing School, and Paramedical School, respectively. Conclusions: From the perspective of the faculty members, there were several barriers to research activities, the most important of which was related to the individual domain and financial support for the researcher. Furthermore, the specification of the research process by eliminating cumbersome administrative rules and creating a balance between obligatory hours dedicated to research and education can be an effective stage in the process of performing research activities.","PeriodicalId":408913,"journal":{"name":"Trends in Medical Sciences","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115242167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Duy Khanh Nguyen, D. Nguyen, M. Le, Long D. Le, H. Tran, Nhân Hữu Kha, A. V. Trần, Bao Lam Thai Tran
Background: Deep vein thrombosis (DVT) is a severe complication in patients with acute ischemic stroke. It can cause severe pulmonary embolism, which may result in death. DVT prevalence in ischemic stroke patients ranges from 20 to 70%. Enoxaparin in prophylactic treatment can decrease the risk of developing DVT in patients with acute ischemic stroke. However, optimal enoxaparin dosing for prophylactic treatment in DVT remains elusive. Dosing between 0.3 - 0.5 IU/mL could decrease the prevalence of DVT without increased complications. Objectives: This study aims to evaluate the benefits and risks of prophylactic treatment in DVT patients with dosing of enoxaparin (Lovenox of Sanofi-Aventis Vietnam Company) 40 mg (4,000 units of anti-Xa, 0.4 mL) once daily. Methods: Following a cross-sectional design, 58 patients with acute ischemic stroke, who met the inclusion criteria, were studied. Participants received prophylactic treatment of the lower extremities DVT with enoxaparin. Results: The mean Wells score was 2.14 ± 0.35. Based on the Wells criteria for DVT, all cases had paralysis, muscle weakness, and bedridden recently > 3 days. Also, 4 cases (6.9%) had leg edema; 1 case (1.7%) had superficial collateral veins; 3 cases (5.3%) had previously documented DVT. Thrombocytopenia > 50% after treatment has a non-statistically significant decrease. The 2nd ultrasound showed no case of DVT. Conclusions: Enoxaparin was not the primary cause of thrombocytopenia in prophylactic treatment. Enoxaparin is a 100% effective means to prevent lower extremity DVT in average-risk patients, and it does not increase the risk of bleeding.
{"title":"Enoxaparin in the Prevention of Deep Vein Thrombosis in Patients with Acute Ischemic Stroke","authors":"Duy Khanh Nguyen, D. Nguyen, M. Le, Long D. Le, H. Tran, Nhân Hữu Kha, A. V. Trần, Bao Lam Thai Tran","doi":"10.5812/tms-122415","DOIUrl":"https://doi.org/10.5812/tms-122415","url":null,"abstract":"Background: Deep vein thrombosis (DVT) is a severe complication in patients with acute ischemic stroke. It can cause severe pulmonary embolism, which may result in death. DVT prevalence in ischemic stroke patients ranges from 20 to 70%. Enoxaparin in prophylactic treatment can decrease the risk of developing DVT in patients with acute ischemic stroke. However, optimal enoxaparin dosing for prophylactic treatment in DVT remains elusive. Dosing between 0.3 - 0.5 IU/mL could decrease the prevalence of DVT without increased complications. Objectives: This study aims to evaluate the benefits and risks of prophylactic treatment in DVT patients with dosing of enoxaparin (Lovenox of Sanofi-Aventis Vietnam Company) 40 mg (4,000 units of anti-Xa, 0.4 mL) once daily. Methods: Following a cross-sectional design, 58 patients with acute ischemic stroke, who met the inclusion criteria, were studied. Participants received prophylactic treatment of the lower extremities DVT with enoxaparin. Results: The mean Wells score was 2.14 ± 0.35. Based on the Wells criteria for DVT, all cases had paralysis, muscle weakness, and bedridden recently > 3 days. Also, 4 cases (6.9%) had leg edema; 1 case (1.7%) had superficial collateral veins; 3 cases (5.3%) had previously documented DVT. Thrombocytopenia > 50% after treatment has a non-statistically significant decrease. The 2nd ultrasound showed no case of DVT. Conclusions: Enoxaparin was not the primary cause of thrombocytopenia in prophylactic treatment. Enoxaparin is a 100% effective means to prevent lower extremity DVT in average-risk patients, and it does not increase the risk of bleeding.","PeriodicalId":408913,"journal":{"name":"Trends in Medical Sciences","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121157186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Previous studies have shown the altered levels of long-chain polyunsaturated fatty acids (LCPUFAs) in pathological hypoxic conditions. Elevated soluble fms-like tyrosine kinase-1 (sFlt-1) expression in hypoxia plays an important role in the pathogenesis of placental as preeclampsia. Objectives: The eicosapentaenoic acid (EPA; 20:5, n-3) as LCPUFAs (omega-3) might attenuate sFlt-1 and hypoxia-inducible factor-1α (HIF-1α) expressions and secretions. Methods: JEG-3 cells were incubated with dimethyloxalylglycine (DMOG) and EPA. The SFlt-1 gene expression was determined using a real-time polymerase chain reaction. The protein secretion of sFlt-1 and HIF-1α were analyzed using Western blot. Results: The incubation of JEG-3 cells with DMOG significantly elevated messenger ribonucleic acid (mRNA) expression and protein secretion of sFlt-1 (P < 0.05); nevertheless, EPA decreased mRNA expression and protein secretion of sFlt-1 (P < 0.05). Moreover, EPA inhibited the effect of DMOG on sFlt-1 (P = 0.0361) gene expression and protein secretion and HIF-1α (P = 0.0241) protein secretion. Conclusions: The sFlt-1 expression decreased by n-3 fatty acids in trophoblast tumor cell line under induced hypoxia conditions. It seems that changes in sFlt-1 expression are mediated by the transcription factor HIF-1α.
{"title":"Effect of Eicosapentaenoic Acid on sFlt-1 and HIF-1α Expression Under Induced Hypoxia Conditions in Trophoblast Tumor Cell Line (JEG-3)","authors":"Cobra Moradian, B. Motlagh, Zahra Afshari","doi":"10.5812/tms-122263","DOIUrl":"https://doi.org/10.5812/tms-122263","url":null,"abstract":"Background: Previous studies have shown the altered levels of long-chain polyunsaturated fatty acids (LCPUFAs) in pathological hypoxic conditions. Elevated soluble fms-like tyrosine kinase-1 (sFlt-1) expression in hypoxia plays an important role in the pathogenesis of placental as preeclampsia. Objectives: The eicosapentaenoic acid (EPA; 20:5, n-3) as LCPUFAs (omega-3) might attenuate sFlt-1 and hypoxia-inducible factor-1α (HIF-1α) expressions and secretions. Methods: JEG-3 cells were incubated with dimethyloxalylglycine (DMOG) and EPA. The SFlt-1 gene expression was determined using a real-time polymerase chain reaction. The protein secretion of sFlt-1 and HIF-1α were analyzed using Western blot. Results: The incubation of JEG-3 cells with DMOG significantly elevated messenger ribonucleic acid (mRNA) expression and protein secretion of sFlt-1 (P < 0.05); nevertheless, EPA decreased mRNA expression and protein secretion of sFlt-1 (P < 0.05). Moreover, EPA inhibited the effect of DMOG on sFlt-1 (P = 0.0361) gene expression and protein secretion and HIF-1α (P = 0.0241) protein secretion. Conclusions: The sFlt-1 expression decreased by n-3 fatty acids in trophoblast tumor cell line under induced hypoxia conditions. It seems that changes in sFlt-1 expression are mediated by the transcription factor HIF-1α.","PeriodicalId":408913,"journal":{"name":"Trends in Medical Sciences","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132900263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pouya Safarzadeh Kozani, Pooria Safarzadeh Kozani, A. Sheikhi
{"title":"Idecabtagene Vicleucel: The Ultimate CAR T-Cell Therapy for Multiple Myeloma?","authors":"Pouya Safarzadeh Kozani, Pooria Safarzadeh Kozani, A. Sheikhi","doi":"10.5812/tms.123859","DOIUrl":"https://doi.org/10.5812/tms.123859","url":null,"abstract":"<jats:p />","PeriodicalId":408913,"journal":{"name":"Trends in Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122957759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Bahrami, Vahid Kheirandish, Kosar Mousavi, Fatemeh Hosseini Nik, Liley Mahmudi
Background: In Iran, the presence of the patient’s family is forbidden at coronary care units (CCUs), and the patient will be hospitalized without the presence of the family at these units. The issue of being away from family is one of the main causes of tenseness in patients of CCUs and has some side effects, such as isolation and seclusion, after discharge. Objectives: The present study aimed to investigate the effect of face-to-face visiting and behind-the-glass visiting on patients’ anxiety at CCUs. Methods: This quasi-experimental study was performed on 80 random patients at the CCU of Dr. Ganjavian hospital, Dezful, Iran, by considering inclusion and exclusion criteria. The visiting time in both groups was 20 minutes, and the questionnaires were collected by the researchers from patients 10 minutes before and after visiting. Results: The average obvious and hidden anxiety in patients significantly reduced after the visit. Anxiety in the group of face-to-face visiting was more reduced than in the other group [face-to-face (P = 0.0008) and behind-the-glass (P = 0.02)]. Conclusions: Face-to-face visiting is an appropriate method to reduce anxiety in the patients of CCUs. It is suggested to adopt this method to improve the visits in this unit.
背景:在伊朗，冠状动脉监护病房(CCUs)禁止患者家属在场，患者将在没有家属在场的情况下住院。远离家人的问题是ccu患者紧张的主要原因之一，并且在出院后会产生一些副作用，如隔离和隔离。目的:本研究旨在探讨面对面访问和玻璃后访问对CCUs患者焦虑的影响。方法:采用纳入和排除标准，随机选取伊朗Dezful Dr. Ganjavian医院CCU收治的80例患者进行准实验研究。两组访视时间均为20分钟，访视前后10分钟由研究人员收集问卷。结果:访视后患者明显焦虑和隐性焦虑的平均水平明显降低。面对面访视组的焦虑程度明显低于另一组[面对面(P = 0.0008)和玻璃后(P = 0.02)]。结论:面对面拜访是减少ccu患者焦虑的合适方法。建议采用这种方法来提高该单位的访问量。
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