{"title":"Determination of Knowledge, Attitudes and Behaviors of Healthcare Service Providers on Sorting of Biomedical Wastes","authors":"E. Kartal","doi":"10.20515/OTD.939936","DOIUrl":"https://doi.org/10.20515/OTD.939936","url":null,"abstract":"","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126729650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Dolgun, N. Acar, E. Ozakın, F. Kaya, M. Çanakçı, E. Arslan, T. Çağlayan
The aim of the study was to evaluate the compliance of the number of B-lines on focused lung ultrasound with the clinical heart failure classification of the New York Heart Association (NYHA) and NT-proBNP levels in the emergency department. This prospective study was conducted in a tertiary university hospital emergency department. Patients over 18 years of age complaining of shortness of breath or heart failure diagnosis between January 2016 and July 2016. The number of B-lines according to the BLUE point regions was measured. Correlations between the clinical heart failure stage, NT-proBNP level and number of B-lines on ultrasonography were analyzed. Of the 143 patients, 92 (64.3%) were male and 51 (35.7%) were female. The median age was 73.00 (66.00-79.00). There was a very strong correlation between the number of B-lines and NYHA stages for each region (r > 0.85 for all variables; p <0.001 for all). There was also a strong and direct correlation between the number of B-lines and the NT-proBNP levels for each region (r > 0.70; p <0.001). Regarding the shortness of breath numerical score (r > 0.45; p <0.001), there was an inverse relationship with ejection fraction (EF). The relationship between the EF and BLUE points was moderate, but negative and significant (p <0.001). NT-proBNP levels, the NHYA classification, and lung ultrasound can be used as a tool in the emergency department for a faster diagnosis and decision-making in lung congestion.
{"title":"Strong and Direct Correlation in Heart Failure Between B-Lines and NT-ProBNP Levels","authors":"H. Dolgun, N. Acar, E. Ozakın, F. Kaya, M. Çanakçı, E. Arslan, T. Çağlayan","doi":"10.20515/OTD.906035","DOIUrl":"https://doi.org/10.20515/OTD.906035","url":null,"abstract":"The aim of the study was to evaluate the compliance of the number of B-lines on focused lung ultrasound with the clinical heart failure classification of the New York Heart Association (NYHA) and NT-proBNP levels in the emergency department. This prospective study was conducted in a tertiary university hospital emergency department. Patients over 18 years of age complaining of shortness of breath or heart failure diagnosis between January 2016 and July 2016. The number of B-lines according to the BLUE point regions was measured. Correlations between the clinical heart failure stage, NT-proBNP level and number of B-lines on ultrasonography were analyzed. Of the 143 patients, 92 (64.3%) were male and 51 (35.7%) were female. The median age was 73.00 (66.00-79.00). There was a very strong correlation between the number of B-lines and NYHA stages for each region (r > 0.85 for all variables; p <0.001 for all). There was also a strong and direct correlation between the number of B-lines and the NT-proBNP levels for each region (r > 0.70; p <0.001). Regarding the shortness of breath numerical score (r > 0.45; p <0.001), there was an inverse relationship with ejection fraction (EF). The relationship between the EF and BLUE points was moderate, but negative and significant (p <0.001). NT-proBNP levels, the NHYA classification, and lung ultrasound can be used as a tool in the emergency department for a faster diagnosis and decision-making in lung congestion.","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128596199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tip fakultesi ogrencilerinin COVID-19 hastaligi ile ilgili bilgi duzeylerinin saptanmasi, iliskili oldugu dusunulen bazi degiskenlerin incelenmesi ve COVID-19 hastaligi ile ilgili davranislarinin degerlendirilmesi amaclanmistir. 01.08.2020-30.10.2020 tarihleri arasinda Eskisehir Osmangazi Universitesi Tip Fakultesi ogrencileri uzerinde yapilan kesitsel tipte bir arastirmadir. 984 ogrenci calisma grubunu olusturdu. Yazarlar tarafindan hazirlanan 26 soru ile ogrencilerin COVID-19 hastaligi ile ilgili bilgileri, 15 soru ile davranislari degerlendirildi. Her dogru cevaba “1 puan” verildi, yanlis cevaplara puan verilmedi. Mann Whitney U testi ve Kruskal Wallis Analizi kullanilmistir. Calisma grubunda 501 (%50.9) kadin vardi. Yaslari 17-35 arasinda degismekteydi, ortalama 20.77±2.18 yil idi. Ogrencilerin COVID-19 hastaligi ile ilgili bilgi sorularindan aldiklari puanlar 5-25 arasinda degismekte olup ortalama 18.82±3.16 puan idi. Parcalanmis aile yapisina sahip olanlarda, dorduncu sinif ve uzerinde ogrenim gormekte olanlarda ve hastalik hakkinda bilgisinin yeterli oldugunu bildirenlerde COVID-19 hastaligi ile ilgili bilgi puanlarinin daha yuksek oldugu saptanmistir (her biri icin; p≤0.05). Bu calismada en cok dogru bilinen bilgi sorusu %97.4 ile “COVID-19 hastaliginin etkeni ile temas edenler 14 gun sure ile izolasyona alinir” iken en cok yanlis bilinen ise %64.8 ile “Tibbi olmayan kumas maskelerin koruyuculugu yoktur” bilgi sorusu idi. Ogrencilerin COVID-19 hastaligi ile ilgili davranis sorularindan aldiklari puanlar 0-15 arasinda degismekte olup ortalama 10.00±2.02 idi. Ogrencilerin COVID-19 hastaligi ile ilgili bilgileri iyi duzeydeydi, bilgi ve davranis duzeyleri arasinda pozitif yonde zayif bir iliski vardi. Bilgi duzeylerinin arttirilmasi icin yetkin saglik otoriteleri tarafindan daha etkili bilgilendirme calismalarinin yapilmasi yararli olabilir. Hastalik hakkinda bilgi ve davranis duzeyleri arasindaki iliskinin ortaya konabilmesi icin daha kapsamli calismalara ihtiyac vardir.
{"title":"Bir Tıp Fakültesi Öğrencilerinin COVID-19 Hastalığı ile İlgili Bilgi Düzeylerinin ve Davranışlarının Değerlendirilmesi","authors":"Selva Dilan Gölbaşi, Sevil Sungur, Hatice Aygar, Sevil Aydoğan Gedik, Seval Çalışkan Pala, C. Çam, Didem Oktar, Ahmet Ay, Tuğçe Arslan Torba, Didem Arslantaş, Alaettin Unsal","doi":"10.20515/OTD.907362","DOIUrl":"https://doi.org/10.20515/OTD.907362","url":null,"abstract":"Tip fakultesi ogrencilerinin COVID-19 hastaligi ile ilgili bilgi duzeylerinin saptanmasi, iliskili oldugu dusunulen bazi degiskenlerin incelenmesi ve COVID-19 hastaligi ile ilgili davranislarinin degerlendirilmesi amaclanmistir. 01.08.2020-30.10.2020 tarihleri arasinda Eskisehir Osmangazi Universitesi Tip Fakultesi ogrencileri uzerinde yapilan kesitsel tipte bir arastirmadir. 984 ogrenci calisma grubunu olusturdu. Yazarlar tarafindan hazirlanan 26 soru ile ogrencilerin COVID-19 hastaligi ile ilgili bilgileri, 15 soru ile davranislari degerlendirildi. Her dogru cevaba “1 puan” verildi, yanlis cevaplara puan verilmedi. Mann Whitney U testi ve Kruskal Wallis Analizi kullanilmistir. Calisma grubunda 501 (%50.9) kadin vardi. Yaslari 17-35 arasinda degismekteydi, ortalama 20.77±2.18 yil idi. Ogrencilerin COVID-19 hastaligi ile ilgili bilgi sorularindan aldiklari puanlar 5-25 arasinda degismekte olup ortalama 18.82±3.16 puan idi. Parcalanmis aile yapisina sahip olanlarda, dorduncu sinif ve uzerinde ogrenim gormekte olanlarda ve hastalik hakkinda bilgisinin yeterli oldugunu bildirenlerde COVID-19 hastaligi ile ilgili bilgi puanlarinin daha yuksek oldugu saptanmistir (her biri icin; p≤0.05). Bu calismada en cok dogru bilinen bilgi sorusu %97.4 ile “COVID-19 hastaliginin etkeni ile temas edenler 14 gun sure ile izolasyona alinir” iken en cok yanlis bilinen ise %64.8 ile “Tibbi olmayan kumas maskelerin koruyuculugu yoktur” bilgi sorusu idi. Ogrencilerin COVID-19 hastaligi ile ilgili davranis sorularindan aldiklari puanlar 0-15 arasinda degismekte olup ortalama 10.00±2.02 idi. Ogrencilerin COVID-19 hastaligi ile ilgili bilgileri iyi duzeydeydi, bilgi ve davranis duzeyleri arasinda pozitif yonde zayif bir iliski vardi. Bilgi duzeylerinin arttirilmasi icin yetkin saglik otoriteleri tarafindan daha etkili bilgilendirme calismalarinin yapilmasi yararli olabilir. Hastalik hakkinda bilgi ve davranis duzeyleri arasindaki iliskinin ortaya konabilmesi icin daha kapsamli calismalara ihtiyac vardir.","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125751925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It was aimed to investigate the effect of malnutrition with and the risk of malnutrition in elderly individuals with regards to other geriatric syndromes and comprehensive geriatric assessment (CGA) parameters. Patients who applied to the geriatric outpatient clinic between January 2019 and June 2020 were included in the study. 460 patients were examined. The patients were divided into three groups according to malnutrition, malnutrition-risk, and normal nutritional status. These three groups were compared in terms of geriatric syndromes and CGA parameters. The well-nourished group and the risk of malnutrition and malnutrition group were compared in terms of geriatric syndromes and CGA parameters adjusted for age and gender. Of 460 patients, 64.5% of these patients were female, and the mean age was 77.75±8.12, 65 had malnutrition, and 141 had malnutrition-risk. When the well-nourished group was compared with the malnutrition and malnutrition-risk group, age, education year, frequency of cerebrovascular disease were statistically different. The frequency of falls, dementia, sleep disturbance, urinary incontinence, orthostatic hypotension, polypharmacy, sarcopenia, and frailty was higher in groups with malnutrition and malnutrition-risk than in the normal group (p<0.05). Also, activities of daily living (ADLs) and gait and balance scores were lower in the group with malnutrition and malnutrition risk (p<0.05). In the regression analysis adjusted for age and gender, geriatric depression, urinary incontinence, dementia, orthostatic hypotension, sarcopenia, and frailty were increased in the group with malnutrition and malnutrition risk compared to the normal group (p<0.05). Malnutrition and risk of malnutrition is associated with other geriatric syndromes and deterioration in ADLs. Therefore, nutritional evaluation must be included in the assessment of older adults, and necessary interventions should be made to optimize the nutritional status.
{"title":"Nutritional Status Might Be Related to Physical Performance and Functionality in Older Adults","authors":"Suleyman Emre Kocyigit, Ali Ekrem Aydin, A. Işık","doi":"10.20515/OTD.936969","DOIUrl":"https://doi.org/10.20515/OTD.936969","url":null,"abstract":"It was aimed to investigate the effect of malnutrition with and the risk of malnutrition in elderly individuals with regards to other geriatric syndromes and comprehensive geriatric assessment (CGA) parameters. Patients who applied to the geriatric outpatient clinic between January 2019 and June 2020 were included in the study. 460 patients were examined. The patients were divided into three groups according to malnutrition, malnutrition-risk, and normal nutritional status. These three groups were compared in terms of geriatric syndromes and CGA parameters. The well-nourished group and the risk of malnutrition and malnutrition group were compared in terms of geriatric syndromes and CGA parameters adjusted for age and gender. Of 460 patients, 64.5% of these patients were female, and the mean age was 77.75±8.12, 65 had malnutrition, and 141 had malnutrition-risk. When the well-nourished group was compared with the malnutrition and malnutrition-risk group, age, education year, frequency of cerebrovascular disease were statistically different. The frequency of falls, dementia, sleep disturbance, urinary incontinence, orthostatic hypotension, polypharmacy, sarcopenia, and frailty was higher in groups with malnutrition and malnutrition-risk than in the normal group (p<0.05). Also, activities of daily living (ADLs) and gait and balance scores were lower in the group with malnutrition and malnutrition risk (p<0.05). In the regression analysis adjusted for age and gender, geriatric depression, urinary incontinence, dementia, orthostatic hypotension, sarcopenia, and frailty were increased in the group with malnutrition and malnutrition risk compared to the normal group (p<0.05). Malnutrition and risk of malnutrition is associated with other geriatric syndromes and deterioration in ADLs. Therefore, nutritional evaluation must be included in the assessment of older adults, and necessary interventions should be made to optimize the nutritional status.","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132068520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gastrointestinal stromal tumor (GIST) gastrointestinal sistemin en sik gorulen, kajal hucrelerinden koken alan mezenkimal tumorudur. Siklikla 50 yas sonrasi ve %60 oraninda midede, ikinci siklikla jejunum ve ileumda (%30) gorulur. Ince barsak yerlesimliler midede bulunanlara gore %40-50 daha fazla malign seyirlidir. Ayrica ince bagirsak GISTleri mide GISTleri gibi ayirt edici histolojik alt tipler olusturmazlar. Cogunlukla igsi hucrelidirler. Epiteloidler ise cok kucuk bir kismini olusturur. Bizim sunacagimiz olguda epiteloid ve igsi hucre ozelliklerine ek olarak pleksiform buyume paterni ve zeminde miksoid stroma bulunmaktadir.
{"title":"Pleksiform Miksoid Gastrointestinal Stromal Tümör, İnce Barsak Yerleşimli Nadir Bir Histolojik Patern: Olgu Sunumu","authors":"Leymune Parlak, Rabia Altunbaş, E. Özdemir, Emine Zeynep Tarini, Buket Gedik","doi":"10.20515/OTD.913177","DOIUrl":"https://doi.org/10.20515/OTD.913177","url":null,"abstract":"Gastrointestinal stromal tumor (GIST) gastrointestinal sistemin en sik gorulen, kajal hucrelerinden koken alan mezenkimal tumorudur. Siklikla 50 yas sonrasi ve %60 oraninda midede, ikinci siklikla jejunum ve ileumda (%30) gorulur. Ince barsak yerlesimliler midede bulunanlara gore %40-50 daha fazla malign seyirlidir. Ayrica ince bagirsak GISTleri mide GISTleri gibi ayirt edici histolojik alt tipler olusturmazlar. Cogunlukla igsi hucrelidirler. Epiteloidler ise cok kucuk bir kismini olusturur. Bizim sunacagimiz olguda epiteloid ve igsi hucre ozelliklerine ek olarak pleksiform buyume paterni ve zeminde miksoid stroma bulunmaktadir.","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123143651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nadire Eser, H. S. Büyüknacar, E. Kumcu, C. Göçmen
The aim of this study was to investigate the effect of neocuproine (NC), a selective Cu(I) chelator, on the spontaneous contractions (SC) and basal tension (BT) in isolated mouse bladder tissues. The spontaneous contractions and basal tension in the isolated bladder strips were recorded to evaluate the amplitude and frequency parameters. NC (100 μM) caused a significant inhibition on spontaneous contractions (SC) in the isolated mouse bladder. We also evaluated the effects of cuprizone, a selective Cu(II)-chelator, and various selective or nonselective purinoceptor antagonists on the SC and also on the basal tension (BT). Of them, a non-selective purinergic antagonist suramin, a P2X receptor antagonist PPADS, a P2X3 antagonist NF 110, a P2 receptor activator ATP or a P2Y1 antagonist MRS 2179 significantly reversed NC-induced inhibition on the SC whereas cuprizone was found ineffective. The results showed that both P2X and P2Y receptors are playing role in the inhibitory effect of NC on the mouse bladder function. Ca2+ addition to the organ bath medium also dose-dependently reversed the NC-induced inhibition suggesting the role of myogenic mechanism. These findings suggest that intracellular calcium reduction, purinergic pathway and Cu(I) but not Cu(II) may have an important role in the inhibitory activity of NC on mouse bladder function.
{"title":"The Copper (I) Chelator Neocuproine Inhibits Mouse Bladder Function, but not the Copper (II) Chelator Cuprizone","authors":"Nadire Eser, H. S. Büyüknacar, E. Kumcu, C. Göçmen","doi":"10.20515/OTD.894353","DOIUrl":"https://doi.org/10.20515/OTD.894353","url":null,"abstract":"The aim of this study was to investigate the effect of neocuproine (NC), a selective Cu(I) chelator, on the spontaneous contractions (SC) and basal tension (BT) in isolated mouse bladder tissues. The spontaneous contractions and basal tension in the isolated bladder strips were recorded to evaluate the amplitude and frequency parameters. NC (100 μM) caused a significant inhibition on spontaneous contractions (SC) in the isolated mouse bladder. We also evaluated the effects of cuprizone, a selective Cu(II)-chelator, and various selective or nonselective purinoceptor antagonists on the SC and also on the basal tension (BT). Of them, a non-selective purinergic antagonist suramin, a P2X receptor antagonist PPADS, a P2X3 antagonist NF 110, a P2 receptor activator ATP or a P2Y1 antagonist MRS 2179 significantly reversed NC-induced inhibition on the SC whereas cuprizone was found ineffective. The results showed that both P2X and P2Y receptors are playing role in the inhibitory effect of NC on the mouse bladder function. Ca2+ addition to the organ bath medium also dose-dependently reversed the NC-induced inhibition suggesting the role of myogenic mechanism. These findings suggest that intracellular calcium reduction, purinergic pathway and Cu(I) but not Cu(II) may have an important role in the inhibitory activity of NC on mouse bladder function.","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127276609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gulcin Gunden, Sevginaz Işik, H. Ü. Teke, O. Çilingir, Nur Oğuz Davutoğlu, E. Erzurumluoglu, S. Kocagil, S. Artan, B. D. Aras
Chronic lymphocytic leukemia (CLL) is known as type of leukemia originating from clonal mature B lymphocytes and has genetic heterogeneity. Many studies have been done to clarify the genome of CLL. In these studies, del(13q) is reported as the most common chromosomal aberration. Although this anomaly is associated with good prognosis when isolated, patients have clinical heterogeneity. In addition, in many gene mutations including TP53, NOTCH1 and SF3B1 gene mutations, poor prognosis has been identified. The prognostic significance of these genes has begun to be demonstrated. According to these data, we aimed to determine the mutation rate of NOTCH1 and SF3B1 genes and to investigate the prognostic effects (disease stages, TTFT and OS) in 43 cases with isolated del(13q) by using FISH method. We investigated the most common mutations of NOTCH1 and SF3B1 gene in CLL by using Sanger sequencing method. While frameshift 7541_7542delCT mutation was detected in the NOTCH1 gene in 1 out of 42 CLL cases with clinical heterogeneity, mutation in the SF3B1 gene couldn’t be detected. As a result of our study, it was observed that NOTCH1 and SF3B1 gene mutations weren’t associated with isolated del(13q) which is compatible with the literature data. Our study is the first study that evaluates NOTCH1 and SF3B1 gene mutations with prognostic parameters of isolated del(13q) with CLL patients in the Turkish population. As a result; It was concluded that there may be different reasons responsible for the clinical heterogeneity of isolated del(13q) cases and further studies are needed to reveal these reasons
{"title":"Analyzing The Mutations Of Notch1 And Sf3b1 Genes In Cases With CLL Detected Isolated 13q Deletion","authors":"Gulcin Gunden, Sevginaz Işik, H. Ü. Teke, O. Çilingir, Nur Oğuz Davutoğlu, E. Erzurumluoglu, S. Kocagil, S. Artan, B. D. Aras","doi":"10.20515/OTD.916009","DOIUrl":"https://doi.org/10.20515/OTD.916009","url":null,"abstract":"Chronic lymphocytic leukemia (CLL) is known as type of leukemia originating from clonal mature B lymphocytes and has genetic heterogeneity. Many studies have been done to clarify the genome of CLL. In these studies, del(13q) is reported as the most common chromosomal aberration. Although this anomaly is associated with good prognosis when isolated, patients have clinical heterogeneity. In addition, in many gene mutations including TP53, NOTCH1 and SF3B1 gene mutations, poor prognosis has been identified. The prognostic significance of these genes has begun to be demonstrated. According to these data, we aimed to determine the mutation rate of NOTCH1 and SF3B1 genes and to investigate the prognostic effects (disease stages, TTFT and OS) in 43 cases with isolated del(13q) by using FISH method. We investigated the most common mutations of NOTCH1 and SF3B1 gene in CLL by using Sanger sequencing method. While frameshift 7541_7542delCT mutation was detected in the NOTCH1 gene in 1 out of 42 CLL cases with clinical heterogeneity, mutation in the SF3B1 gene couldn’t be detected. As a result of our study, it was observed that NOTCH1 and SF3B1 gene mutations weren’t associated with isolated del(13q) which is compatible with the literature data. Our study is the first study that evaluates NOTCH1 and SF3B1 gene mutations with prognostic parameters of isolated del(13q) with CLL patients in the Turkish population. As a result; It was concluded that there may be different reasons responsible for the clinical heterogeneity of isolated del(13q) cases and further studies are needed to reveal these reasons","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125541401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Son donemde oksidatif stresin norodejeneratif hastaliklarda onemli rolu olduguna dair bulgular artis gostermektedir. Oksidatif stres ve etkilerinin, kritik beyin bolgelerinde hasara neden oldugu; boylece noronal sinyal iletisimini duzenleyen mekanizmalarda bozulma ile ortaya ciktigi dusunulmektedir. Klinik calismalarda, cesitli norodejeneratif hastaliklardan muzdarip hastalarda antioksidan enzim, lipid peroksidasyonu ve nitrik oksit duzeylerinde belirgin degisiklikler saptanmistir. Mitokondri kompleksinde elektron akisi sirasinda bazi elektronlarin zincirden kacmasi ile reaktif oksijen radikalleri olusmakta ve elektron transport zincir inhibisyonu ile mitokondrial islev bozuklugu gelismektedir. Mitokondrial islev bozuklugu ve oksidatif hasar, hucre ici sinyal sisteminde, hucre ici kalsiyum dengesinde ve DNA yapisinda degisiklikler olusturarak sinir sisteminde kalici olumsuzluklara neden olabilir. Bu makalede, mevcut bilgiler gozden gecirilerek, klinik, hayvan ve hucre kulturu calismalari ile norodejeneratif hastaliklarin oksidatif denge ile iliskisi analiz edilmistir.
最近，越来越多的证据表明，氧化应激在神经退行性疾病中扮演着重要角色。氧化应激及其影响被认为会对重要的大脑区域造成损害，导致调节神经元信号的机制受损。临床研究发现，各种神经退行性疾病患者体内的抗氧化酶、脂质过氧化和一氧化氮水平都发生了显著变化。在线粒体复合体的电子流动过程中，当一些电子从链条中逸出时就会形成活性氧自由基，线粒体功能障碍就会随着电子传递链的抑制而产生。线粒体功能障碍和氧化损伤可能导致细胞内信号系统、细胞内钙平衡和 DNA 结构发生变化，并可能给神经系统带来永久性问题。本文通过临床、动物和细胞培养研究，回顾了目前的知识，并分析了氧化平衡与神经退行性疾病之间的关系。
{"title":"Nörodejeneratif Hastalıklarda Oksidatif Stresin Rolü","authors":"Güllü Kaymak, H. Aydin","doi":"10.20515/OTD.845217","DOIUrl":"https://doi.org/10.20515/OTD.845217","url":null,"abstract":"Son donemde oksidatif stresin norodejeneratif hastaliklarda onemli rolu olduguna dair bulgular artis gostermektedir. Oksidatif stres ve etkilerinin, kritik beyin bolgelerinde hasara neden oldugu; boylece noronal sinyal iletisimini duzenleyen mekanizmalarda bozulma ile ortaya ciktigi dusunulmektedir. Klinik calismalarda, cesitli norodejeneratif hastaliklardan muzdarip hastalarda antioksidan enzim, lipid peroksidasyonu ve nitrik oksit duzeylerinde belirgin degisiklikler saptanmistir. Mitokondri kompleksinde elektron akisi sirasinda bazi elektronlarin zincirden kacmasi ile reaktif oksijen radikalleri olusmakta ve elektron transport zincir inhibisyonu ile mitokondrial islev bozuklugu gelismektedir. Mitokondrial islev bozuklugu ve oksidatif hasar, hucre ici sinyal sisteminde, hucre ici kalsiyum dengesinde ve DNA yapisinda degisiklikler olusturarak sinir sisteminde kalici olumsuzluklara neden olabilir. Bu makalede, mevcut bilgiler gozden gecirilerek, klinik, hayvan ve hucre kulturu calismalari ile norodejeneratif hastaliklarin oksidatif denge ile iliskisi analiz edilmistir.","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131111505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"İleri Yaşlı Hastalarda (85 yaş ve üzeri) İnkarsere İnguinal Herni Cerrahisi Deneyimlerimiz","authors":"Murat Kartal","doi":"10.20515/OTD.912572","DOIUrl":"https://doi.org/10.20515/OTD.912572","url":null,"abstract":"","PeriodicalId":409672,"journal":{"name":"Osmangazi Journal of Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125842078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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