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Bio-inspired Hardware Central Pattern Generator (hCPG) as a Therapy for Cardiorespiratory Disease 仿生硬件中枢模式发生器(hCPG)在心血管疾病治疗中的应用
Pub Date : 2016-05-24 DOI: 10.4108/EAI.3-12-2015.2262517
Ashok S. Chauhan, Le Zhao, J. Paton, A. Nogaret
We report on a hCPG device, which is a network of silicon neurons, and its applications to cardiorespiratory therapy. We study the chaotic dynamics of neurons that compete through mutually inhibitory synapses and demonstrate the emergence of multistable behavior. We were able to select the spatio-temporal sequences associated with stable modes of oscillation by imparting different initial conditions with timed current steps mimicking delayed stimuli. We constructed the phase lag maps of the hCPG for various connectivities of the network. We also describe a simpler two neuron hCPG which generates a two-phase rhythmic pattern for vagus nerve stimulation and modulation of heart rate by respiration to obtain artificial respiratory sinus-arrhythmia (RSA).
我们报道了一种hCPG装置,它是一个硅神经元网络,及其在心肺治疗中的应用。我们研究了通过相互抑制突触竞争的神经元的混沌动力学,并证明了多稳定行为的出现。我们可以通过赋予不同的初始条件和模拟延迟刺激的定时电流步来选择与稳定振荡模式相关的时空序列。我们针对不同的网络连接构造了hCPG的相位滞后图。我们还描述了一种更简单的双神经元hCPG,它产生两相节律模式,通过呼吸刺激迷走神经和调节心率,从而获得人工呼吸窦性心律失常(RSA)。
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引用次数: 0
A Consideration of Realizing the Brain Inspired Computer 实现脑启发计算机的思考
Pub Date : 2016-05-24 DOI: 10.4108/EAI.3-12-2015.2262461
Kosuke Nishihara, Norihiko Taya, Toshiyuki Kanoh
Characteristics of Ultra-large Scale, Ultra-high Autonomy, and Ultra-low Power are required for the system which is necessary to solve social problems we will face in the future. In order to realize them, we focused on the mechanism of brain which features excellent scalability, environmental adaptability, and power-saving ability. In this paper, we consider about the new computing architecture, Brain Inspired Computing, which is based upon the brain mechanism.
该系统需要具备超大规模、超高自治、超低功耗的特点,这是解决未来社会问题所必需的。为了实现这些目标,我们重点研究了具有良好可扩展性、环境适应性和节能能力的大脑机制。在本文中,我们考虑了一种新的计算架构,即基于大脑机制的脑启发计算。
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引用次数: 4
A Study of the Role of the Maintained-Discharge Parameter in the Divisive Normalization Model of V1 Neurons 维持放电参数在V1神经元分裂归一化模型中的作用研究
Pub Date : 2016-05-24 DOI: 10.4108/EAI.3-12-2015.2262400
T. Sawada, A. Petrov
The divisive normalization model [Heeger, 1992] accounts successfully for a wide range of phenomena observed in single-cell physiological recordings from neurons in primary visual cortex (V1). Using mathematical analyses and simulation experiments, we investigated the role of the maintained-discharge (base firing rate) parameter in this model. We developed an implementation that can take grayscale images as inputs and applied it to the types of visual stimuli used in a comprehensive suite of published physiological studies. We found that three empirical phenomena are closely associated with the maintained-discharge parameter: (A) the existence of inhibitory regions in the receptive fields of simple cells in V1, (B) the supersaturation effect in the contrast sensitivity curves, and (C) the narrowing/widening of the spatial-frequency tuning curves when the stimulus contrast decreases. The model predicts two patterns of these phenomena: One possibility is that a neuron can show A, B, and widening (C); the other possibility is to show not-A, not-B, and narrowing (C). This interdependence is a potentially falsifiable prediction of the divisive normalization model.
分裂归一化模型[Heeger, 1992]成功地解释了初级视觉皮层(V1)神经元单细胞生理记录中观察到的广泛现象。通过数学分析和仿真实验,研究了维持放电(基本射速)参数在该模型中的作用。我们开发了一种实现方法,可以将灰度图像作为输入,并将其应用于一系列已发表的生理学研究中使用的视觉刺激类型。我们发现,维持放电参数与三个经验现象密切相关:(A) V1简单细胞感受野中存在抑制区,(B)对比敏感性曲线的过饱和效应,(C)刺激对比度降低时空间-频率调谐曲线变窄/变宽。该模型预测了这些现象的两种模式:一种可能性是神经元可以显示a、B和扩展(C);另一种可能性是显示非a、非b和缩小(C)。这种相互依赖是分裂归一化模型的潜在可证伪预测。
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引用次数: 2
Changes in variance of neuronal signals may be perceptually relevant for stereo vision 神经元信号方差的变化可能与立体视觉的感知相关
Pub Date : 2016-05-24 DOI: 10.4108/EAI.3-12-2015.2262431
Nela Cicmil, A. Parker, K. Krug
We measured the variance/mean (v/m) ratio of neuronal firing rates in visual areas V1, V2 and V5/MT in response to correlated and anti-correlated random dot stereograms. Disparity-selective neurons in early visual areas V1 and V2 showed no significant difference in v/m ratios to the two types of stereo-stimuli, but neurons in area V5/MT had a significantly greater v/m ratio for anti-correlated compared to correlated stimuli. These results demonstrate that neurons in a visual area higher in the cortical hierarchy have a greater response variability to anti-correlated stimuli, which do not give rise to a coherent stereo percept. A recurrent cortical network including V5/MT that quenches neural variability may contribute to solving the stereo correspondence problem.
我们测量了V1、V2和V5/MT视觉区神经元放电率的方差/均值(v/m)比,以响应相关和反相关的随机点立体图。早期视觉区V1和V2的差异选择神经元对两种立体刺激的v/m比无显著差异,但V5/MT区神经元对反相关刺激的v/m比显著高于相关刺激。这些结果表明,皮层层次较高的视觉区域的神经元对反相关刺激有更大的反应变异性,这不会产生连贯的立体感知。包括V5/MT在内的周期性皮层网络抑制神经变异性,可能有助于解决立体对应问题。
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引用次数: 1
Robust Functional Profile Identification for DSC Thermograms DSC热图的鲁棒功能轮廓识别
Pub Date : 2016-05-24 DOI: 10.4108/EAI.3-12-2015.2262549
A. M. Kwon, D. Ren, Ming Ouyang, N. Garbett
Differential scanning calorimetry is an emerging technique with an attempt to characterize a subject's disease status according to heat capacity profiles, which are called thermograms. However, thermograms exhibit large shape variations, and the sample size is typically small. Therefore, it is important to extract robust characterization of thermograms representing the clinical status for further study. The current study identifies the representative heat capacity profiles from functional principle components which are derived from the bootstrap distribution of the deepest heat capacity function according to the functional data depth, instead of the original thermogram data set. 71 thermograms are obtained from two groups (healthy, cervical carcinoma), and functional PCA are conducted with the original thermogram data set and the bootstrap data set of the deepest heat capacity functions. Examining the first three PCs of the two groups between the two data sets, the bootstrap data set shows more distinctive difference in modes of variation between the two groups in comparison with the original thermogram data set, and the representative heat profiles are reconstructed with the PCs which are derived from the bootstrap sample sets. 90% confidence intervals of the representative heat profiles can be directly obtained from the same bootstrap set.
差示扫描量热法是一种新兴技术,它试图根据热容曲线(称为热图)来表征受试者的疾病状态。然而,热像图表现出很大的形状变化,并且样本量通常很小。因此,提取具有鲁棒性表征的代表临床状态的热像图以供进一步研究是非常重要的。本研究从功能主成分中识别具有代表性的热容剖面,而不是从原始热图数据集中识别具有代表性的热容剖面,该热容剖面是根据功能数据深度从最深层热容函数的bootstrap分布中得到的。从两组(健康组和宫颈癌组)获得71张热像图,并使用原始热像图数据集和最深层热容函数的bootstrap数据集进行功能性PCA。对两组数据集之间的前3个pc进行检验,与原始热像图数据集相比,自举数据集在两组之间的变化模式差异更明显,并使用自举样本集导出的pc重建了代表性的热廓线。有代表性的热廓线90%的置信区间可以直接从同一自举集得到。
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引用次数: 2
A Deconvolutional Competitive Algorithm for Building Sparse Hierarchical Representations 构建稀疏层次表示的反卷积竞争算法
Pub Date : 2016-05-24 DOI: 10.4108/EAI.3-12-2015.2262428
Dylan M. Paiton, Sheng Y. Lundquist, William Shainin, Xinhua Zhang, Peter F. Schultz, Garrett T. Kenyon
Sparse coding methods have been used to study how hierarchically organized representations in the visual cortex can be learned from unlabeled natural images. Here, we describe a novel Deconvolutional Competitive Algorithm (DCA), which explicitly learns non-redundant hierarchical representations by enabling competition both within and between sparse coding layers. All layers in a DCA are trained simultaneously and all layers contribute to a single image reconstruction. Because the entire hierarchy in a DCA comprises a single dictionary, there is no need for dimensionality reduction between layers, such as MAX pooling. We show that a 3-layer DCA trained on short video clips exhibits a clear segregation of image content, with features in the top layer reconstructing large-scale structures while features in the middle and bottom layers reconstruct progressively finer details. Compared to lower levels, the representations at higher levels are more invariant to the small image transformations between consecutive video frames recorded from hand-held cameras. The representation at all three hierarchical levels combine synergistically in a whole image classification task. Consistent with psychophysical studies and electrophysiological experiments, broad, low-spatial resolution image content was generated first, primarily based on sparse representations in the highest layer, with fine spatial details being filled in later, based on representations from lower hierarchical levels.
稀疏编码方法已被用于研究如何从未标记的自然图像中学习视觉皮层中的分层组织表征。在这里,我们描述了一种新的反卷积竞争算法(DCA),它通过启用稀疏编码层内部和之间的竞争来明确地学习非冗余的分层表示。DCA中的所有层都是同时训练的,所有层都有助于单个图像重建。由于DCA中的整个层次结构由单个字典组成,因此不需要在层之间进行降维,例如MAX池。我们表明,在短视频剪辑上训练的3层DCA显示出图像内容的清晰分离,顶层的特征重建大规模结构,而中间层和底层的特征逐渐重建更精细的细节。与较低级别相比,较高级别的表示对手持摄像机记录的连续视频帧之间的小图像变换更加不变性。所有三个层次的表示在整个图像分类任务中协同结合。与心理物理研究和电生理实验一致,首先生成广泛的、低空间分辨率的图像内容,主要基于最高层的稀疏表示,然后根据较低层次的表示填充精细的空间细节。
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引用次数: 4
Evolving Mixed Societies: A one-dimensional modelling approach 进化的混合社会:一维建模方法
Pub Date : 2016-05-24 DOI: 10.4108/EAI.3-12-2015.2262514
M. Bodi, M. Szopek, Payam Zahadat, T. Schmickl
Natural self-organising collective systems like social insect societies are often used as a source of inspiration for robotic applications. In return, developing such self-organising robotic systems can lead to a better understanding of natural collective systems. By unifying the communication channels of the natural and artificial agents these two collective systems can be merged into one bio-hybrid society. In this work we demonstrate the feasibility of such a bio-hybid society by introducing a simple one-dimensional model. A set of patches forms a one-dimensional arena, each patch represents a stationary robot, which is controlled by an AHHS (Artificial Homeostatic Hormone System) control software. The stationary robots are able to produce different types of environmental stimuli. Simulated bees react diversely to the different stimuli types. An evolutionary computation algorithm changes the properties of the AHHS and defines the interactions between the robots and their properties of stimuli emission. The task is an aggregation of simulated bees at a predefined aggregation spot. We demonstrate that an evolved AHHS is a very feasible tool for controlling these stationary robots. Furthermore we show that an AHHS even works robustly in different setups and dynamic environments even though the controller was not specially evolved for these purposes.
自然的自组织集体系统,如群居昆虫社会,经常被用作机器人应用的灵感来源。反过来,开发这种自组织机器人系统可以更好地理解自然集体系统。通过统一自然和人工智能体的沟通渠道,这两个集体系统可以合并成一个生物混合社会。在这项工作中,我们通过引入一个简单的一维模型来证明这种生物杂交社会的可行性。一组贴片构成一个一维的竞技场,每个贴片代表一个静止的机器人,由AHHS (Artificial Homeostatic Hormone System,人工体内平衡激素系统)控制软件控制。这种固定的机器人能够产生不同类型的环境刺激。模拟蜜蜂对不同类型的刺激有不同的反应。一种进化计算算法改变了AHHS的特性,定义了机器人之间的相互作用及其刺激发射特性。该任务是在预定义的聚集点聚集模拟蜜蜂。我们证明了一个进化的AHHS是一个非常可行的工具来控制这些静止的机器人。此外,我们表明AHHS甚至可以在不同的设置和动态环境中健壮地工作,即使控制器不是专门为这些目的而进化的。
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引用次数: 1
Coordination of Contractility, Adhesion and Flow in Migrating Physarum Amoebae : Experiments and Modeling 阿米巴绒泡菌迁移过程中收缩、粘附和流动的协调:实验和模型
Pub Date : 2016-05-24 DOI: 10.4108/EAI.3-12-2015.2262456
R. Guy, Owen L. Lewis, Shun Zhang, J. C. Álamo
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引用次数: 1
Adaptive dynamics for shape optimization inspired by the use-and-growth rule in a simple organism of slime mold 受简单黏菌使用与生长规律启发的形状优化自适应动力学
Pub Date : 2016-05-24 DOI: 10.4108/EAI.3-12-2015.2262501
T. Nakagaki
A kind of huge amoeboid organism named {¥it Physarum} plasmodium constructs a intricate network of veins for circulating nutrients and signals over the entire body. The network shape is drastically re-organized within an hour in response to external conditions. We may extract an algorithm for optimal design of functional network from the primitive organism.
一种巨大的变形虫生物,叫做绒泡菌疟原虫,在整个身体中构建了一个复杂的静脉网络,用于循环营养物质和信号。网络形状会在一小时内根据外部条件进行彻底的重组。我们可以从原始生物中提取功能网络的优化设计算法。
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引用次数: 0
Children Lung Function Diagnostics - New Methods For Handling of Clinical Data 儿童肺功能诊断-处理临床资料的新方法
Pub Date : 2016-05-24 DOI: 10.4108/EAI.3-12-2015.2262457
J. Horáček, V. Koucký, M. Hladík
In our talk we would like to introduce a new approach to handling of clinical data obtained during children lung function testing. We focus on multiple breath inert gas washout test (MBW) which is a new and promising method. We combine traditional approaches with unconventional methods of interval analysis. That helps us to develop new robust algorithms not suffering from typical drawbacks of classical methods. These algorithms enable further processing of the clinical data extrapolation, prediction, regression, checking validity of measurement.
在我们的演讲中,我们将介绍一种处理儿童肺功能测试中获得的临床数据的新方法。多次呼吸惰性气体冲洗试验(MBW)是一种很有前途的新方法。我们将传统的方法与非常规的区间分析方法相结合。这有助于我们开发新的鲁棒算法,而不会遭受经典方法的典型缺点。这些算法能够进一步处理临床数据外推,预测,回归,检查测量的有效性。
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引用次数: 0
期刊
International Conference on Bio-inspired Information and Communications Technologies
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