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Effect of intraoperative vasopressor use on free flap outcome following major head-and-neck reconstructive surgeries 术中使用血管升压药对头颈部大型重建手术后游离皮瓣效果的影响
IF 0.1 Q4 Medicine Pub Date : 2020-07-01 DOI: 10.4103/jhnps.jhnps_53_20
S. Rajan, Karthik C. Babu, Pulak Tosh
Introduction: Major head-and-neck surgeries involving wide excision of the tumor usually necessitate reconstruction with free flaps for tissue cover. Even with meticulous fluid management with crystalloids, colloids, albumin, blood, and blood products, many patients become hemodynamically unstable and require the use of vasopressors perioperatively. Objectives: The purpose of this analysis was to assess the safety, role, and present-day trends of the use of vasopressor agents in free flap surgeries and to find any relation of graft rejection or failure of flap surgeries or postoperative complications with perioperative use of such agents. Methods: Reviewing the literature regarding the usage of vasopressors in head-and-neck free flap surgeries, percentage of flap survival, thrombosis of the artery, venous edema, and need for revision surgery were analyzed. Most of the published data had shown that optimizing hemodynamic stability with vasopressors had a more beneficial effect on overall flap perfusion and minimized the complications of iatrogenic fluid overload. The common conclusion was that perioperative vasopressor administration was not detrimental to free flap survival. Conclusion: Based on available data, it is concluded that perioperative use of vasopressors does not adversely affect free flap outcome in patients undergoing head-and-neck reconstructive surgeries and could even be beneficial considering the avoidance of complications of liberal intravenous fluid administration.
引言:涉及肿瘤广泛切除的主要头颈部手术通常需要用游离皮瓣进行组织覆盖重建。即使使用晶体、胶体、白蛋白、血液和血液制品进行精细的液体管理,许多患者的血液动力学也会变得不稳定,需要在围手术期使用血管升压药。目的:本分析的目的是评估血管升压药在游离皮瓣手术中的安全性、作用和当前趋势,并发现移植排斥反应或皮瓣手术失败或术后并发症与围手术期使用此类药物的任何关系。方法:回顾有关血管升压药在头颈部游离皮瓣手术中的应用、皮瓣存活率、动脉血栓形成、静脉水肿以及翻修手术的必要性的文献。大多数已发表的数据表明,使用血管升压药优化血液动力学稳定性对皮瓣整体灌注有更有益的影响,并将医源性液体超负荷的并发症降至最低。普遍的结论是围手术期使用血管升压药对游离皮瓣的存活率没有损害。结论:根据现有数据,可以得出结论,在接受头颈部重建手术的患者中,围手术期使用血管升压药不会对游离皮瓣的效果产生不利影响,甚至可以避免自由静脉输液的并发症。
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引用次数: 1
Characteristics and patterns of surgical interventions in differentiated thyroid cancer with distant metastasis 分化型甲状腺癌症远处转移手术干预的特点与模式
IF 0.1 Q4 Medicine Pub Date : 2020-07-01 DOI: 10.4103/jhnps.jhnps_54_20
M. Kathar, P. Jain, K. Manikantan, R. Sharan, A. Pattatheyil
Objective: Unlike most head and neck cancers, the presence of distant metastasis (DM) does not preclude curative intent treatment and surgical interventions are common in metastatic disease. This research attempts to study the demographics, patterns of metastasis, and surgical interventions in patients of differentiated thyroid cancer (DTC) with DM. Materials and Methods: The retrospective cohort study of thirty-two patients of DTC with radiologically or histopathologically/cytopathologically confirmed DM who underwent surgery at a tertiary care center from August 2011 to December 2018. Results: The study population comprised of 59% of women and had a median age of 55 (19–79) years. Thorax was the most common site of metastasis, documented in 56% patients, while 53% of patients had bone metastases. Multiple DM were noted in 8 patients. Surgery for metastatic sites was possible in 14 patients (44%), with debulking and spine fixation being the most common surgical intervention for metastasis. The median dose of radioactive iodine (RAI) received by patients was 400 (25–749) mCi in one to four sessions (median-2 sessions). Three patients received conventional chemotherapy, while four received Sorafenib. Conclusion: Metastasectomy in DTC with DM is feasible in selected patients, and surgical interventions are most commonly performed on the spine to prevent neurological complications. RAI ablation is universally administered in this subset of patients and in very high doses, often distributed in multiple sessions. The role of chemotherapy and tyrosine kinase inhibitor is still restricted to palliative settings and cost constraints remain a detriment to more widespread use.
目的:与大多数头颈癌不同,远处转移(DM)的存在并不排除治疗意图,手术干预在转移性疾病中很常见。本研究旨在研究分化型癌症(DTC)合并DM患者的人口统计学、转移模式和手术干预。材料和方法:对2011年8月至2018年12月在三级护理中心接受手术的32名经放射学或组织病理学/细胞病理学证实的糖尿病性糖尿病患者进行回顾性队列研究。结果:研究人群由59%的女性组成,中位年龄为55(19-79)岁。胸部是最常见的转移部位,56%的患者记录在案,而53%的患者有骨转移。8例患者出现多发性糖尿病。14名患者(44%)可以对转移部位进行手术治疗,其中去毛刺和脊柱固定是转移最常见的手术干预措施。患者接受的放射性碘(RAI)的中位剂量在一到四个疗程(中位-2疗程)中为400(25-749)mCi。三名患者接受常规化疗,四名患者接受索拉非尼。结论:DTC合并DM的转移切除术在选定的患者中是可行的,并且手术干预最常见于脊柱,以预防神经系统并发症。RAI消融术在这部分患者中普遍使用,剂量非常高,通常分布在多个疗程中。化疗和酪氨酸激酶抑制剂的作用仍然局限于姑息治疗,成本限制仍然不利于更广泛的使用。
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引用次数: 0
Conducting interdepartmental tele-joint clinic during the coronavirus disease 2019 pandemic in a tertiary cancer care center 2019冠状病毒病大流行期间在三级癌症护理中心开展跨部门远程联合门诊
IF 0.1 Q4 Medicine Pub Date : 2020-07-01 DOI: 10.4103/jhnps.jhnps_59_20
K. Bhattacharya, S. Kulkarni, A. Janu, Anand Jadhav, S. Nair, A. Joshi, N. Khattry, Sudeep Gupta, N. Shetty
Introduction: The coronavirus disease 2019 pandemic has posed numerous challenges to health care across the globe. Time is of the essence in cancer care to prevent disease progression. Materials and Methods: TrueConf ®, a local area network-based software, has been used for holding joint clinic meetings which are an essential part of cancer management at our hospital. Results: A total of 12 meetings were held over a period of 12 weeks where 42 patients were examined and their clinicoradiological evaluation was done. Further treatment decisions were made based on these joint clinics. Conclusion: TrueConf ® is an economical platform and easily implementable system, easing decision-making for critical cases, avoiding crowding in outpatient departments.
简介:2019冠状病毒病大流行给全球医疗保健带来了许多挑战。时间是癌症预防疾病进展的关键。材料和方法:TrueConf®是一种基于局域网的软件,用于召开联合临床会议,这是我院癌症管理的重要组成部分。结果:在12周的时间里,共举行了12次会议,对42名患者进行了检查,并对他们进行了临床病理评估。根据这些联合诊所做出了进一步的治疗决定。结论:TrueConf®是一个经济实惠的平台,易于实施,简化了危重病例的决策,避免了门诊拥挤。
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引用次数: 0
Prognosticators for quality of life in surgically treated head-and-neck cancer patients 手术治疗头颈癌患者生活质量的预后因素
IF 0.1 Q4 Medicine Pub Date : 2020-07-01 DOI: 10.4103/jhnps.jhnps_57_20
N. Gupta, Shripal Jani, Priya Dubey, Zainab Fidvi, M. Kapre
Introduction: Physiological, functional, and psychological implications of head-and-neck cancer treatment are significant. Improving outcomes in cancer care must include due diligence to quality of life (QOL) along with disease control. This study assesses QOL of head-and-neck cancer patients before and after treatment and explores predictive factors. Materials and Methods: Prospective observational study of consecutive head-and-neck cancer patients. QOL assessments were made at baseline, and different stages of their treatment and prognostic factors such as age, gender, socioeconomic strata, comorbidities, tumor stage, requirement of reconstruction, adjuvant treatment, were examined. EORTC QOL questionnaire-H and N0 35 were employed, and prognostic factor correlation was studied by logistic regression analysis. Results: Ninety-eight patients at least 12 months post-treatment scored worst for dryness of the mouth (33.4), followed by sticky saliva (23.4). Although results steadily improved over time, this did not reach statistical significance (P = 0.235). Stage of the primary tumor, requirement of reconstruction, and adjuvant treatment were statistically significant prognostic factors (P < 0.05). Conclusion: Understanding of QOL parameters would improve treatment planning, counseling of head-and-neck cancer patients and care-givers and enable physical, functional, and social rehabilitation.
引言:头颈部癌症治疗的生理、功能和心理意义重大。改善癌症护理的结果必须包括对生活质量(QOL)的尽职调查以及疾病控制。本研究评估了癌症头颈部患者治疗前后的生活质量,并探讨了预测因素。材料与方法:对连续的癌症头颈部患者进行前瞻性观察研究。在基线时进行生活质量评估,并检查其治疗的不同阶段和预后因素,如年龄、性别、社会经济阶层、合并症、肿瘤分期、重建要求、辅助治疗。采用EORTC生活质量问卷-H和N0 35,并通过logistic回归分析研究预后因素相关性。结果:治疗后至少12个月的98名患者口腔干燥评分最差(33.4),其次是唾液粘稠(23.4)。尽管随着时间的推移,结果稳步改善,但这并没有达到统计学意义(P=0.235),结论:了解癌症患者和护理人员的生活质量参数有助于改善其治疗计划和咨询,促进其身体、功能和社会康复。
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引用次数: 0
A Clinical Study of Second Branchial Cleft Anomalies: Our Experience in a Teaching Hospital in Northern India 第二鳃裂畸形的临床研究:我们在印度北部一家教学医院的经验
IF 0.1 Q4 Medicine Pub Date : 2020-07-01 DOI: 10.4103/jhnps.jhnps_28_20
M. Anoop, R. Avtar, W. Akhtar, Y. Yadav
Background: Branchial cleft anomalies are of five types. Among these, second branchial cleft anomalies are the most common developmental disorders. The aim of the study was to evaluate the clinical data in various subsets among the patients who had been diagnosed and treated for second branchial anomalies in the past 2 years. Materials and Methods: The present study was a retrospective study conducted from January 2018 to January 2020 in our institute. We collected the clinical data from patient’s medical records, radiological reports, surgical files, and histopathological reports. Results: A total of 22 patients presented with second branchial cleft anomalies. Among these, 18 (81.8%) were branchial cysts and 4 (18.2%) were branchial sinuses. There was no branchial fistula. The highest number of cases belonged to the second decade (72.7%). The mean age was found to be 16.8 years. The male-to-female ratio was 1.75:1. The rural-to-urban ratio was 3.4:1. There was no proclivity to any one side of the neck. All 22 patients underwent surgical excision as the treatment. There was no recurrence. Conclusion: We concluded that branchial cysts are the main type among second branchial cleft anomalies. Most patients belonged to the second decade of life. Early detection and reaching correct diagnosis are the major factors influencing treatment outcome. Preferably, surgical excision has to be performed in noninfected neck. Meticulous dissection helps in avoiding recurrence. Genetic disorders such as branchio-oto-renal syndrome have to be kept in mind in the evaluation of any branchial cleft anomalies.
背景:鳃裂畸形可分为五种类型。其中,第二鳃裂异常是最常见的发育障碍。本研究的目的是评估在过去2年中诊断和治疗过第二鳃裂异常的患者的不同亚群的临床资料。材料与方法:本研究为回顾性研究,于2018年1月至2020年1月在我所进行。我们从患者的医疗记录、放射学报告、手术档案和组织病理学报告中收集临床资料。结果:22例患者出现第二鳃裂畸形。其中鳃裂囊肿18例(81.8%),鳃裂窦4例(18.2%)。无鳃裂瘘。病例数最多的是第二个十年(72.7%)。平均年龄为16.8岁。男女比例为1.75:1。城乡比例为3.4:1。颈部的任何一侧都没有倾斜。22例患者均行手术切除治疗。无复发。结论:鳃裂囊肿是第二鳃裂畸形的主要类型。大多数患者属于生命的第二个十年。早期发现和正确诊断是影响治疗效果的主要因素。最好在未感染的颈部进行手术切除。细致的解剖有助于避免复发。遗传性疾病,如支耳肾综合征,必须牢记在评估任何鳃裂异常。
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引用次数: 2
Response to "Ocular Melanoma: A Rare Entity" 对“眼黑色素瘤:一种罕见的实体”的反应
IF 0.1 Q4 Medicine Pub Date : 2020-07-01 DOI: 10.4103/jhnps.jhnps_8_20
M. Al-Mendalawi
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引用次数: 0
Interleukins in Periodontics 牙周病中的白细胞介素
IF 0.1 Q4 Medicine Pub Date : 2020-07-01 DOI: 10.4103/jhnps.jhnps_26_20
Shivani Sachdeva, H. Saluja, Amit Mani, Tanupriya Sonkar
Key modulators of inflammation are interleukins (ILs). There is a complex network of interactions in acute and chronic inflammation which is modulated by ILs. Mechanistic explanations for positive and negative interactions between individual ILs will also depend on new insights into the signal transduction pathways for each IL. ILs are the cytokines that act specifically as mediators between leukocytes. Approximately more than 35 ILs have been described, each having unique biological activity and role in periodontal health or disease. It seems quite likely that the lymphocyte may behave in a manner similar as a neuron that receives information from several other neurons and integrates the positive and negative signals and then corresponds accordingly by initiating or refraining from initiating action potential. Like a neuron, the response of the lymphocyte will depend both on the positive and negative signals and also on the nature of their individual signal transduction pathways.
炎症的关键调节剂是白细胞介素(il)。在急性和慢性炎症中有一个复杂的相互作用网络,由il调节。单个白细胞介素之间积极和消极相互作用的机制解释也将取决于对每种白细胞介素信号转导途径的新见解。白细胞介素是白细胞之间特异性作为介质的细胞因子。大约有超过35种il被描述,每一种都有独特的生物活性和在牙周健康或疾病中的作用。淋巴细胞的行为方式似乎很可能类似于一个神经元,它接收来自其他几个神经元的信息,整合积极和消极的信号,然后通过启动或抑制启动动作电位来做出相应的反应。像神经元一样,淋巴细胞的反应既取决于正信号和负信号,也取决于它们各自信号转导途径的性质。
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引用次数: 0
Developing the South Asian region's first head-and-neck surgical oncology multi-institutional program: Journey, milestones, challenges, and future 发展南亚地区首个头颈外科肿瘤学多机构项目:历程、里程碑、挑战和未来
IF 0.1 Q4 Medicine Pub Date : 2020-07-01 DOI: 10.4103/jhnps.jhnps_46_20
D. Mandlik, S. Chopra, D. Balasubramanian, V. Kekatpure, S. Iyer, J. Dabholkar, Kaustubh D. Patel
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引用次数: 0
Pattern of Head-and-Neck Malignancies in the Pediatric Population 儿童头颈部恶性肿瘤的发病模式
IF 0.1 Q4 Medicine Pub Date : 2020-07-01 DOI: 10.4103/jhnps.jhnps_21_20
V. Mungutwar, Manya Thakur, Harbans Singh, Sushma Singh, D. Hota
Background: Head-and-neck malignancies are uncommon in childhood unlike in adults, also it contributes to low proportion of overall cancer incidence among children. The number in India has been increasing in the recent past. Hence, we conducted a study to know the pattern of head-and-neck cancers in hospitalized patients of 0–18 years’ age group. Aim: The aim was to study the pattern of different types of head-and-neck malignancies in the pediatric age group (<18 years) in a referral hospital. Subject and Methods: We have conducted an observational study of pediatric head-and-neck malignancies in our tertiary care center. All children in the age group of 0–18 years were included in the study. A total of 72 cases were taken retrospectively and prospectively from various departments of hospital which deal with pediatric patients. Results: Our study comprises total 72 cases, maximum cases were of acute lymphocytic leukemia with secondaries in neck n = 21, followed by 9 cases were of acute myeloid leukemia with secondaries in the neck. Carcinomas of the nasopharynx and parotid both were 8 in number; 15 cases were of Hodgkin/non-Hodgkin lymphoma with involvement of neck nodes. The least number of cases was of carcinoma mandible, Burkitt lymphoma, and chronic myeloid leukemia with secondary neck nodes. Most cases presented with right-sided neck mass or lymphadenopathy. Male-to-female ratio was 1.78:1 in all cases. Most of the cases were diagnosed either by bone marrow aspiration biopsy, fine-needle aspiration cytology, or excisional biopsy. Conclusion: Malignancy is one of the differentials of pediatric neck masses. Hematological malignancies and lymphomas are still two major contributors of head-and-neck cancers in the pediatric age group.
背景:与成人不同,头颈部恶性肿瘤在儿童期并不常见,它也导致儿童癌症总发病率较低。印度的这一数字最近一直在增加。因此,我们进行了一项研究,以了解0-18岁年龄组住院患者的头颈癌模式。目的:研究转诊医院中儿童年龄组(<18岁)不同类型头颈部恶性肿瘤的发病模式。主题和方法:我们在我们的三级护理中心对儿童头颈部恶性肿瘤进行了一项观察性研究。所有0-18岁年龄组的儿童都被纳入了这项研究。共有72例病例是从医院处理儿科患者的各个部门进行回顾性和前瞻性研究的。结果:我们的研究共包括72例病例,其中21例为颈部继发的急性淋巴细胞白血病,其次是颈部继发的9例急性髓系白血病。鼻咽和腮腺癌共8例;霍奇金/非霍奇金淋巴瘤合并颈部淋巴结15例。病例数最少的是下颌骨癌、伯基特淋巴瘤和伴有继发性颈淋巴结的慢性粒细胞白血病。大多数病例表现为右侧颈部肿块或淋巴结病。男女比例均为1.78:1。大多数病例是通过骨髓穿刺活检、细针穿刺细胞学或切除活检诊断的。结论:恶性肿瘤是儿童颈部肿块的一种鉴别诊断方法。血液系统恶性肿瘤和淋巴瘤仍然是儿童年龄组头颈癌的两个主要原因。
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引用次数: 0
Flaps based on facial arteriovenous system for the reconstruction of head-and-neck cancer defects 基于面部动静脉系统的皮瓣重建癌症头颈部缺损
IF 0.1 Q4 Medicine Pub Date : 2020-07-01 DOI: 10.4103/jhnps.jhnps_56_20
Nageswara R. Noothanapati, Krishnakumar Thankappan, N. Akali, T. Patel, D. Balasubramanian, S. Iyer
Facial artery is a branch of the external carotid system extending from the upper neck to the nasion. Various flaps are described in the literature based on the facial artery and vein in the neck and face to reconstruct the head-and-neck cancer defects, either superiorly based or inferiorly based. This article summarizes the flaps and their variations based on the facial arteriovenous system. The flap harvest techniques, the indications, advantages and the limitations of the nasolabial flap, facial artery myomucosal flap, and submental flap are described, with appropriate case demonstrations. Variations of the flaps are also discussed.
面动脉是颈外动脉系统的一个分支,从上颈部延伸到鼻窦。文献中描述了基于颈部和面部的面动脉和静脉的各种皮瓣重建头颈部肿瘤缺损,无论是基于上基还是基于下基。本文综述了基于面部动静脉系统的皮瓣及其变异。本文介绍了鼻唇瓣、面动脉肌粘膜瓣和颏下瓣的手术方法、适应证、优点和局限性,并进行了病例说明。还讨论了皮瓣的变化。
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引用次数: 2
期刊
Journal of Head & Neck Physicians and Surgeons
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