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Hardening mechanism of waste polyolefin mixtures in the presence of modified bentonite clay 改性膨润土存在下废聚烯烃混合物的硬化机理
Pub Date : 2023-10-31 DOI: 10.29235/1561-8323-2023-67-5-433-440
V. M. Shapovalov, D. L. Podobed, S. V. Zotov, A. A. Boyka
The aim of the work is to obtain and study polymer composite materials based on mixtures of secondary polyolefins and modified polydisperse bentonite clay. The formation features of the structure of mixtures of waste polyolefins in the presence of this-type filler are studied. The data on the changes in the mechanical strength of mixed composites, as well as the results of physico-chemical studies are presented. Mixtures based on waste polymers in the presence of highly dispersed particles of modified polydisperse bentonite are characterized by the improvement of the strength of composites due to increased interfacial interaction in them and by the formation of structure uniformity of the material. This to some extent compensates for the loss of cohesive strength of secondary polymers due to thermal degradation processes. The following conclusions are made: at the phase boundaries, the molecular mobility of polymer chains decreases, which leads to changing the crystallization conditions and to appearing a nonequilibrium stress state; introducing bentonite increases crystalline due to the initiation of physico-chemical interaction; the strength grows due to increased interfacial interaction and structure uniformity; the formation mechanism of a complex of properties of composites consists of two-level adsorption – a modifier on filler particles and active polymer groups on the modified filler surface.
本工作的目的是制备和研究基于二次聚烯烃与改性多分散膨润土混合的高分子复合材料。研究了该填料存在下废聚烯烃混合物结构的形成特征。给出了混合复合材料力学强度变化的数据和理化研究结果。以高分散改性多分散膨润土颗粒为基础的废聚合物混合物的特点是由于其中界面相互作用的增加和材料结构均匀性的形成而提高了复合材料的强度。这在一定程度上弥补了由于热降解过程而造成的二次聚合物内聚强度的损失。得出以下结论:在相界处,聚合物链的分子迁移率降低,导致结晶条件发生改变,出现非平衡应力状态;引入膨润土后,由于物化相互作用的引发,结晶增加;由于界面相互作用和结构均匀性的增加,强度增加;复合材料性能复合物的形成机理是两级吸附——改性剂对填料颗粒的吸附和改性填料表面活性聚合物基团的吸附。
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引用次数: 0
Сomparative analysis of the species abundance and structure of plant communities involving <i>Rhamnus cathartica</i> in Belarus and in the midwestern regions of the USA Сomparative大鼠属植物群落&lt;i&gt; /i&gt;在白俄罗斯和美国中西部地区
Pub Date : 2023-10-31 DOI: 10.29235/1561-8323-2023-67-5-399-409
A. V. Spirydovich, N. B. Vlasava, A. D. Ahabalayeva, D. V. Dubovik, A. N. Skuratovich, Yu. K. Vinogradova, V. N. Reshetnikov
The history of intentional introduction of Rhamnus cathartica L. into the Midwestern regions of the USA is briefly described. The species abundance and structure of plant communities, in which Rhamnus cathartica, a native species for Belarus and invasive in the USA grows, has been studied. We compared the studied parameters (floristic description of the monitoring plots, field enumeration of Rhamnus cathartica individuals, average height, projective coverage of the accompanying herb species) at two permanent sample plots in Belarus and three permanent sample plots in the Midwestern regions of the USA. The data confirmed the hypothesis of increased competitiveness of non-native species in the secondary range (EICA). In American populations, compared to Belarusian populations, Rhamnus cathartica has larger sizes, higher seed production, higher number of juvenile individuals, and higher total number of individuals in the population up to the formation of single-species thickets. Invading Rhamnus cathartica into natural plant communities in the USA reduces the number of herbaceous species 8 times! As control measures, the Minnesota Arboretum has begun balding the areas invaded by Rhamnus cathartica, removing juvenile plants (one to five years old) and replanting native tree species.
简要叙述了美国中西部地区有意引种鼠李(Rhamnus cathartica L.)的历史。本文研究了白俄罗斯本土种、美国入侵种大鼠李(Rhamnus cathartica)的物种丰度和群落结构。在白俄罗斯的2个永久样地和美国中西部的3个永久样地,对监测样地的区系描述、野鼠李个体数、平均高度、伴生草本植物的投影盖度进行了比较。这些数据证实了非本地物种在次要范围(EICA)竞争力增强的假设。在美洲种群中,与白俄罗斯种群相比,大鼠的体型更大,种子产量更高,幼个体数量更多,种群中个体总数更高,直至形成单种灌丛。入侵鼠李鼠(Rhamnus cathartica)进入美国的天然植物群落,使草本物种的数量减少了8倍!作为控制措施,明尼苏达植物园已经开始在被鼠李入侵的地区进行秃顶,移除幼树(1到5岁),重新种植本地树种。
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引用次数: 0
Predictive model for identifying new CYP19A1 ligands on the KNIME analytical platform 在KNIME分析平台上鉴定新的CYP19A1配体的预测模型
Pub Date : 2023-10-31 DOI: 10.29235/1561-8323-2023-67-5-388-398
M. I. Shaladonova, Ya. V. Dzichenka, S. A. Usanov
The purpose of this study was to create a database of the chemical compounds – ligands of human steroid-hydroxylating cytochrome CYP19A1 (aromatase) in order to build a predictive model. The idea was to create a model on the basis of the machinery learning method such as random forest for two types of ligands – with steroidal (I type) and non-steroidal structure (II type). Two predictive models were built with the help of the KNIME analytical platform. Topological descriptors of the chemical structure were used as training data when building a model that takes into account their correlation between the structure of the molecule and the biological effect. The selection of the feature importance of the descriptors, optimal parameters of random forest and the definition of applicability domain of the models were carried out. The assessment of the ability to predict the results of a test sample was performed for each model. The quality marks of the obtained models indicated a rather high predictive ability of the models and the prospects of their use for identification of new human CYP19A1 ligands as potential drugs for treatment of hormone-dependent tumors.
本研究的目的是建立人类类固醇羟化细胞色素CYP19A1(芳香化酶)的化合物配体数据库,以建立预测模型。这个想法是在随机森林等机器学习方法的基础上,为两种类型的配体——具有甾体(I型)和非甾体结构(II型)——创建一个模型。在KNIME分析平台的帮助下,建立了两个预测模型。化学结构的拓扑描述符被用作构建模型时的训练数据,该模型考虑了分子结构与生物效应之间的相关性。对描述符的特征重要性、随机森林的最优参数和模型的适用范围进行了选择。对每个模型预测测试样本结果的能力进行评估。所获得的模型的质量标记表明,该模型具有较高的预测能力,并有望用于鉴定新的人类CYP19A1配体作为治疗激素依赖性肿瘤的潜在药物。
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引用次数: 0
Changes in the level of metallothioneins, zinc and copper in blood plasma of patients with chronic lymphocytic leukemia 慢性淋巴细胞白血病患者血浆金属硫蛋白、锌、铜水平的变化
Pub Date : 2023-10-31 DOI: 10.29235/1561-8323-2023-67-5-410-416
E. I. Slobozhanina, E. V. Shamova, G. P. Zubritskaya, A. Yu. Kohan, E. I. Venskaya, I. Yu. Lendina, D. I. Suvorov, I. A. Iskrov
The relationship between the content of metallothioneins, copper and zinc ions in peripheral blood plasma in chronic lymphocytic leukemia (CLL) depending on the disease progression was studied. It was shown that in patients with CLL in blood plasma with a progressive disease, partial and complete remission, the values of the zinc-to-copper ratios significantly decreased in comparison to similar indicators of practically healthy donors. It was established that in patients with CLL, the level of metallothioneins in blood plasma decreases with the disease progression compared to other studied groups, which indicates a reduced function of cysteine-containing metallothionein proteins. Based on the obtained data, it can be concluded that the zinc-to-copper concentration ratio and the level of metallothionenins in peripheral blood plasma are potential diagnostic and prognostic markers in chronic leukemia.
研究了慢性淋巴细胞白血病(CLL)患者外周血金属硫蛋白、铜、锌离子含量与疾病进展的关系。研究表明,在病情进展、部分缓解和完全缓解的血浆CLL患者中,与实际健康供者的类似指标相比,锌铜比的值显着降低。与其他研究组相比,CLL患者血浆中金属硫蛋白水平随着疾病进展而降低,这表明含半胱氨酸金属硫蛋白的功能降低。根据所获得的数据,可以得出结论,外周血血浆锌铜浓度比和金属硫蛋白水平是慢性白血病潜在的诊断和预后指标。
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引用次数: 0
Integrated assessment of technogenic transformation of the geological environment in the southwestern region of Belarus 白俄罗斯西南地区地质环境技术改造综合评价
Pub Date : 2023-10-31 DOI: 10.29235/1561-8323-2023-67-5-425-432
E. A. Kukharik, A. V. Matveyev
The article presents the results of assessment of technogenic transformation of the geological environment in the territory of the southwestern region of Belarus under the influence of various human economic activities. The research was based on the application of a complex methodology, including the study of published and fund sources, geological, geomorphological, topographic and cadastral maps, plans of settlements, remote survey data and materials of field and route observations, cartometric and cartographic works. It is shown that over the past 150 years, a noticeable restructuring of the earth’s surface, the structure and composition of the cover deposits has taken place in the region. This is due to a hydro-reclamation and residential development of the territory, road and railway construction, mining, accumulation of solid waste and other activities. The total volume of technogenically displaced soils in this area is 780.7 million m3, and the calculated indicator of the intensity of technogenic geological processes is 182 m3/km2/year. It is 2.4 times higher than the total impact on the earth’s surface of the region of modern exogenous geological processes.
本文介绍了在各种人类经济活动的影响下,对白俄罗斯西南部地区境内地质环境进行技术改造的评价结果。这项研究的基础是应用一种复杂的方法,包括研究已出版的和资金来源、地质、地貌、地形和地籍地图、住区规划、远程调查数据和实地和路线观测资料、制图和制图工作。结果表明,在过去的150年里,该地区的地表发生了明显的变化,覆盖层的结构和组成也发生了变化。这是由于境内的水利填海和住宅开发、公路和铁路建设、采矿、固体废物积累等活动造成的。该区技术置换土壤总量为7.807亿m3,技术地质作用强度计算指标为182 m3/km2/年。它比现代外源地质作用对该地区地表的总影响高2.4倍。
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引用次数: 0
Quantum-chemical study of the stability of solvents with respect to strong organic bases 溶剂对强有机碱稳定性的量子化学研究
Pub Date : 2023-10-31 DOI: 10.29235/1561-8323-2023-67-5-380-387
A. V. Kulsha, O. A. Ivashkevich
The possibility of theoretical calculation of the ionization constants of strong organic bases in dimethyl sulfoxide and hexametapole was studied by the DLPNO-CCSD (T) and DFT methods. By comparison with the experimental data available in the literature, it has been established that the error of such calculations lies within 1–2 pKa units. The stability of some ionizing solvents against strong organic bases is investigated, the mechanisms of decomposition of solvent molecules in strongly basic media are predicted, and the corresponding energy barriers are estimated. According to the calculations, among ionizing solvents, hexamethylphosphoramide has the highest resistance to superbases, being able to maintain pH > 50 at room temperature. At the same time, 1,3-dimethyl-2-imidazolidinone gradually decomposes under these conditions, while tetrahydrofuran and pivalonitrile are even less stable.
用DLPNO-CCSD (T)和DFT方法研究了理论计算二甲基亚砜和六偏极中强有机碱电离常数的可能性。通过与文献中已有的实验数据的比较,已经确定这种计算的误差在1-2个pKa单位以内。研究了某些电离溶剂对强有机碱的稳定性,预测了溶剂分子在强碱性介质中的分解机理,并估计了相应的能垒。根据计算,在电离溶剂中,六甲基磷酰胺对超碱的抗性最高,能保持pH >室温下50度。同时,1,3-二甲基-2-咪唑烷酮在这些条件下逐渐分解,而四氢呋喃和戊腈则更不稳定。
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引用次数: 0
Tolerance of several construction materials and polycrystalline SiC to blistering and flecking due to ion implantation and annealing 几种建筑材料和多晶碳化硅对离子注入和退火引起的起泡和斑点的耐受性
Pub Date : 2023-10-31 DOI: 10.29235/1561-8323-2023-67-5-373-379
V. V. Pilko (jr.), F. F. Komarov, V. V. Pilko
The results on the tolerance of several construction materials (D16T alloy, Zr, ЭИ-847, 12Х18Н9Т steels) and polycrystаlline SiC to blistering and flecking after irradiation with 500 keV He+ ions and following annealing have been high-lighted. Samples of stainless steels, zirconium, D16T alloy and silicon carbide were irradiated with helium ions in the range from 1016 to 3 · 1018 ion/cm 2 . Immediately after irradiation and annealing under temperatures from 300 to 750 °C, the optical microscopy was used to study the structure of surface layers. Temperature and fluence ranges of tolerance to blistering and flecking were determined for all examined materials. Primary types of material structure distortions were reviewed.
研究了几种建筑材料(D16T合金、Zr、ЭИ-847、12Х18Н9Т钢)和多晶碳化硅在500 keV He+离子辐照和退火后对起泡和斑点的耐受性。对不锈钢、锆、D16T合金和碳化硅样品进行1016 ~ 3·1018离子/ cm2范围内的氦离子辐照。在300 ~ 750℃的温度下辐照和退火后,立即使用光学显微镜研究表面层的结构。对所有被检测材料的耐起泡和起斑的温度和影响范围进行了测定。综述了材料结构畸变的主要类型。
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引用次数: 0
Role of CD68+ and CD206+ cells in the progression of toxic liver fibrosis in rats CD68+和CD206+细胞在大鼠中毒性肝纤维化进展中的作用
Pub Date : 2023-10-31 DOI: 10.29235/1561-8323-2023-67-5-417-424
E. I. Lebedeva, A. T. Shchastniy, A. S. Babenka
The aim of the work was to evaluate the role of stellate macrophages in a large number of points of toxic liver fibrosis in rats. Liver fibrosis and cirrhosis in male Wistar rats were induced with thioacetamide at a dose of 200 mg/kg animal weight for 17 weeks. Histological preparations of the liver were stained with hematoxylin and eosin according to the Mallory method. Immunohistochemical examination was performed on paraffin sections using monoclonal mouse antibodies CD68 and polyclonal rabbit antibodies CD206. The fibrosis degree was determined according to the Ishak semi-quantitative scale. Toxic liver fibrosis before the start of its transformation into cirrhosis (9 weeks) was accompanied by an increase in the number of CD68+ cells compared with the control. At all subsequent experiment stages, no differences were found in comparison to the control. In the liver of control rats, CD206+ cells were practically absent. Throughout the experiment, their number remained above the control point – 3 weeks. With the progression of liver cirrhosis, a decrease in the number of CD206+ cells was noted, but it did not reach a level of 3 weeks. Morphologically, two different groups of CD68+ cells were identified. One group of cells had a pterygoid shape and they were located mainly in the liver sinusoids. The second group of CD68+ cells had a round shape and different localization. They were detected around the vessels of portal zones, surrounded brown pigment accumulations in connective tissue septa, were observed near single lying groups or groups of giant hepatocytes and liver cells containing brown pigment in the cytoplasm, and were also noted in the foci of necrosis of hepatocytes. Cells, expressing the CD206 marker, are round in shape and are elongated and located in the liver sinusoids. Presumably, round-shaped CD68+ cells perform a phagocytic function, and pterygoid-shaped CD68+ cells transdifferentiate into CD206+ cells that have anti-inflammatory properties.
本工作的目的是评估星状巨噬细胞在大鼠中毒性肝纤维化的大量点中的作用。用200 mg/kg动物体重的硫乙酰胺诱导雄性Wistar大鼠肝纤维化和肝硬化,持续17周。按Mallory法对肝组织进行苏木精和伊红染色。石蜡切片采用小鼠单克隆抗体CD68和兔多克隆抗体CD206进行免疫组化检查。按Ishak半定量评分法测定纤维化程度。与对照组相比,毒性肝纤维化在转化为肝硬化之前(9周)伴有CD68+细胞数量的增加。在随后的所有实验阶段,与对照组相比没有发现差异。在对照大鼠的肝脏中,CD206+细胞几乎不存在。在整个实验过程中,它们的数量保持在控制点(3周)以上。随着肝硬化的进展,CD206+细胞的数量减少,但没有达到3周的水平。形态学上鉴定出两组不同的CD68+细胞。一组细胞呈翼状,主要分布于肝窦内。第二组CD68+细胞呈圆形,定位不同。在门静脉区血管周围,结缔组织间隔褐色色素堆积周围,在单个或成群的巨大肝细胞和细胞质中含有褐色色素的肝细胞附近,在肝细胞坏死灶处也可见。表达CD206标记物的细胞呈圆形,呈细长状,位于肝窦内。据推测,圆形CD68+细胞具有吞噬功能,翼状CD68+细胞转分化为具有抗炎特性的CD206+细胞。
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引用次数: 0
Comparison theorem in blow-up problems for reaction diffusion equations and for their approximations 反应扩散方程爆破问题中的比较定理及其近似
Pub Date : 2023-10-30 DOI: 10.29235/1561-8323-2023-67-5-366-372
D. A. Schadinskii
In this paper, blow-up sufficient conditions and upper bound of blow-up time for solution of Neumann and Dirichlet problems for reaction diffusion equations with non-linear gradient have been obtained. These equations have been found from the comparison of theorems, Jensen’s inequality and conservations laws. By using a similar proof approach for the finite-difference case, the finite-difference scheme was constructed, approximating the above-mentioned Neumann problem, for which sufficient conditions and upper bound of blow-up time, consistent with appropriate conditions and bound for the appropriate differential problem, have been obtained.
本文给出了具有非线性梯度的反应扩散方程的Neumann和Dirichlet问题解的爆破充分条件和爆破时间上界。这些方程是通过比较定理、延森不等式和守恒定律得到的。利用类似的有限差分情形的证明方法,构造了近似上述Neumann问题的有限差分格式,得到了该格式的爆破时间的充分条件和上界,与适当微分问题的适当条件和上界相一致。
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引用次数: 0
On the Bernoulli–Euler–Lagrange–Aitken numerical method for roots of polynomials 关于多项式根的伯努利-欧拉-拉格朗日-艾特肯数值方法
Pub Date : 2023-10-30 DOI: 10.29235/1561-8323-2023-67-359-365
A. V. Lebedev, Yu. V. Trubnikov, M. M. Chernyavsky
The article presents a development of the Euler–Lagrange method for calculation of all roots of an arbitrary polynomial P(z) with complex coefficients based on the calculation of the limits of ratios of determinants (as in the Bernoulli–Aitken–Nikiporets methods) built by means of the Taylor and Laurent series coefficients for the function P′(z) / P(z).
本文提出了欧拉-拉格朗日方法的发展,用于计算具有复系数的任意多项式P(z)的所有根,该方法基于计算行列式比值的极限(如在伯努利-艾特肯-尼基波特方法中),该方法是通过函数P ' (z) / P(z)的泰勒和劳伦级数系数建立的。
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引用次数: 0
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