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Importance of Malignant Core Length in the Detection of Clinically Significant Prostate Cancer in Transrectal Prostate Biopsies 经直肠前列腺活检中恶性核心长度在检测临床显著前列腺癌症中的重要性
IF 0.3 Q4 UROLOGY & NEPHROLOGY Pub Date : 2023-01-09 DOI: 10.4274/jus.galenos.2022.2022.0084
G. Dündar, Anıl Erkan
Objective: To examine cores obtained using prostate biopsy under transrectal ultrasound guidance and determine the ideal total malignant core length for the diagnosis of clinically significant prostate cancer (PCa). Materials and Methods: From the beginning of 2017 to the end of 2021, 1.611 transrectal ultrasonography-guided prostate biopsy procedures were retrospectively analyzed. The data were divided into two groups as PCa and non-cancer (non-Ca) according to the pathology reports. The PCa group was further divided into two subgroups as clinically significant and non-significant. After comparing the core numbers and lengths between the groups, a statistical analysis was undertaken to determine the optimal cut-off value of the total malignant core length in predicting the diagnosis of clinically significant PCa. Results: A total of 1.181 biopsy procedures were included in the evaluation. The mean malignant core lengths of the clinically significant and non-significant PCa groups were 6.7±5.1 and 3.6±2.9, respectively, indicating a statistically significant difference between these subgroups. In the presence of PCa, the mean length of malignant cores was found to have an area under the curve value of 0.708 (95% confidence interval: 0.654-0.759) in the prediction of clinically significant PCa, and it had 56.44% sensitivity and 78.05% specificity at a cut-off value of >4.7 cm. Conclusion
目的:在经直肠超声引导下检查前列腺活检获得的核心,并确定诊断具有临床意义的前列腺癌症(PCa)的理想总恶性核心长度。材料与方法:回顾性分析2017年初至2021年底1.611例经直肠超声引导前列腺活检术。根据病理报告将数据分为PCa和非癌(非Ca)两组。PCa组进一步分为两个亚组,即临床显著组和非显著组。在比较了两组之间的核心数量和长度后,进行了统计分析,以确定总恶性核心长度在预测具有临床意义的前列腺癌诊断中的最佳截止值。结果:共有1.181个活检程序被纳入评估。临床显著和非显著前列腺癌组的平均恶性核心长度分别为6.7±5.1和3.6±2.9,表明这些亚组之间存在统计学显著差异。在PCa存在的情况下,发现恶性核心的平均长度在预测临床显著PCa的曲线下面积值为0.708(95%置信区间:0.654-0.759),在临界值>4.7cm时,其敏感性为56.44%,特异性为78.05%。结论
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引用次数: 0
How an Emergency can Effect Urological Emergencies: COVID-19 急诊如何影响泌尿外科急诊:COVID-19
IF 0.3 Q4 UROLOGY & NEPHROLOGY Pub Date : 2022-12-12 DOI: 10.4274/jus.galenos.2022.2022.0067
Anıl Erkan, G. Dündar, Çağlar Boyacı, M. Kılıç, M. Demirbaş
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引用次数: 0
Relationship of Seminal Plasma Anti-Müllerian Hormone Concentration with Sperm Morphology and Sperm DNA Damage 精浆抗<s:1>勒氏激素浓度与精子形态及精子DNA损伤的关系
IF 0.3 Q4 UROLOGY & NEPHROLOGY Pub Date : 2022-12-01 DOI: 10.4274/jus.galenos.2022.2021.0121
Gurkan Turhan, N. Çil, C. Kabukçu, T. Turan, İ. Fenkçi, Gülçin Abban Mete
Recent investigations have demonstrated that seminal plasma anti-Müllerian hormone (AMH) was associated with sperm count and motility. There was no relation between both semen and blood AMH levels and Kruger morphology and sperm DNA breaks. Observing high numbers of TUNEL-positive sperm in groups, including the normozoospermic group, points to the importance of detecting DNA breaks in idiopathic infertility cases. Both DNA fragmentation testing and conventional semen analysis can be used together for the evaluation of male fertility potential.
最近的研究表明,精浆抗勒氏激素(AMH)与精子数量和活力有关。精液和血液AMH水平与克鲁格形态和精子DNA断裂没有关系。在包括正常精子组在内的组中观察到大量tunel阳性精子,指出了在特发性不孕症病例中检测DNA断裂的重要性。DNA片段检测和传统的精液分析可以一起用于男性生育潜力的评估。
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引用次数: 0
Effects of COVID-19 Lockdown on People’s Sexual Lives in Turkiye 新冠肺炎封锁对土耳其人民性生活的影响
IF 0.3 Q4 UROLOGY & NEPHROLOGY Pub Date : 2022-12-01 DOI: 10.4274/jus.galenos.2022.2022.0034
M. Kılıç, E. Köseoğlu, F. Tekkalan, E. Costantini, F. Trama, E. Illiano, T. Tarcan
Objective: To evaluate the impact of coronavirus disease-2019 (COVID-19) lockdown on the sexual lives of couples who live in Turkiye. Material(s) and Method(s): One hundred ninety-three sexually active participants. While sexual functions were evaluated with the international erectile function index-15 in men and the female sexual function index in women, Hamilton anxiety scale (HAM) was used to measure anxiety level. Married people filled out the Marriage adjustment test (MAT) questionnaire. The effects of the quarantine period on the relationship were evaluated with a questionnaire created specifically for this study. Result(s): Sexual improvement and worsening were observed in 8.8%, and 15%, respectively. It did not change for 76.2%. Sexually deteriorated subjects had a higher HAM score (p=0.003). The MAT score was lower in sexually deteriorated subjects (p=0.004). The rate of sexual worsening was higher in women than in men (28.6% vs. 12%, p=0.02). Women's HAM scores were higher (p=0.002). The MAT score was also found to be higher in women (p=0.0037). 58% of sexually deteriorated participants did not feel safe at home during the COVID-19 period, whereas all of those sexually improved participants felt safe at home. Conclusion(s): During the COVID-19 lockdown period, sexual deterioration was detected in 15% of sexually active people. This worsening was associated with the HAM score. Additionally, it was revealed that feeling safe at home is related to sexual life. While the relationship between sexually worsening and the MAT score was significant in men, it was revealed that the level of anxiety in women affected sexual life more significantly. © Copyright 2022 by the Association of Urological Surgery / Journal of Urological Surgery published by Galenos Publishing House.
目的:评估2019冠状病毒病(新冠肺炎)封锁对居住在土耳其的夫妇性生活的影响。材料和方法:193名性活跃的参与者。男性采用国际勃起功能指数-15评估性功能,女性采用女性性功能指数评估性功能。汉密尔顿焦虑量表(HAM)用于测量焦虑水平。已婚人士填写了婚姻适应测试(MAT)问卷。隔离期对这种关系的影响通过专门为本研究创建的问卷进行了评估。结果:性别改善和恶化的发生率分别为8.8%和15%。76.2%的受试者没有变化。性行为恶化受试者的HAM评分较高(p=0.003)。性行为退化受试者MAT评分较低(p=0.004)。女性的性行为恶化率高于男性(28.6%对12%,p=0.02)。女性HAM评分更高(p=0.002)。女性MAT评分也更高(p=0.0037)。58%的性行为退化参与者新冠肺炎期间在家感觉不安全,而所有性改善的参与者在家感觉安全。结论:在新冠肺炎封锁期间,15%的性活跃者出现性恶化。这种恶化与HAM评分有关。此外,研究表明,在家感到安全与性生活有关。虽然男性的性恶化与MAT评分之间的关系很显著,但研究表明,女性的焦虑程度对性生活的影响更为显著。©泌尿外科协会/Galenos出版社出版的《泌尿外科杂志》版权所有2022。
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引用次数: 0
Water Vapor Thermal Therapy (Rezum™) for Benign Prostate Hyperplasia: Initial Experience from Turkiye 水蒸气热疗(Rezum™) 治疗良性前列腺增生:土耳其的初步经验
IF 0.3 Q4 UROLOGY & NEPHROLOGY Pub Date : 2022-12-01 DOI: 10.4274/jus.galenos.2022.2022.0053
M. Tuna, Tunkut Doğanca, Ömer Burak Argun, B. Z. Pirdal, İ. Tüfek, C. Obek, A. Kural
? Rezum™ system is a safe minimal invasive treatment modality for benign prostate hyperplasia treatment. This is the first study from Turkiye that reports the initial short-term results of Rezum™ therapy.
?Rezum™ 该系统是一种安全的微创治疗良性前列腺增生的方法。这是土耳其第一项报告Rezum初步短期结果的研究™ 治疗
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引用次数: 0
Determining an Approach to Small Testicular Masses by Examining Scrotal Doppler Ultrasonography and Serum Tumor Markers 通过检查阴囊多普勒超声和血清肿瘤标志物确定睾丸小肿块的方法
IF 0.3 Q4 UROLOGY & NEPHROLOGY Pub Date : 2022-12-01 DOI: 10.4274/jus.galenos.2022.2021.0123
I. Erol
Objective: In our study, we retrospectively analyzed the pathology results of radical orchiectomy operations performed in our clinic and to correlate preoperative color Doppler ultrasonography (CDUSG) findings with small-testicular masses (SmTM) with negative serum tumor markers (STM). Materials and Methods: Male patients (n=98) who underwent radical orchiectomy between January 2010 and January 2021 to treat intratesticular solid lesions that were detected via CDUSG were evaluated retrospectively. All patients were evaluated in terms of age, atrophic testis, echogenicity, size of tumoral lesions, testicular palpability, preoperative STM and postoperative pathology results. Results: Expression of at least one STM was elevated in 58 (59.2%) patients preoperatively. STM elevation continued to occur in 25 (25.5%) patients postoperatively; furthermore, 81 (82.7%) patients presented with malignant pathology. The mean age of patients was 39.47±15.20 years, whereas the mean age of patients with benign pathology was higher than patients with malignant pathology (p=0.008). The mean size of malignant lesions was significantly greater than that of benign lesions (5.4 vs 3.5 cm; p=0.033). Statistically elevated STM, lower age, heterogeneity in CDUSG, and large lesion size were found as parameters predicting malignancy. Although lesions in 9 (45%) of 20 STM-negative patients with a lesion smaller than 3 cm were benign, benign pathology was detected in 6 (75%) of 8 STM-negative patients with a lesion smaller than 1.5 cm. Conclusion: CDUSG plays an important role in detecting small non-palpable masses. Especially in STM-negative patients with a SmTM, CDUSG can reasonably guide the decision-making phase although it cannot provide definitive diagnosis. Radical orchiectomy, which is the traditional approach for all solid testicular lesions, leads to unnecessary treatment in patients with benign lesions, so testicular-sparing surgery should be preferred in STM-negative non-palpable SmTMs because the risk of cancer is low.
目的:在我们的研究中,我们回顾性分析了我们临床上进行的睾丸根治术的病理结果,并将术前彩色多普勒超声(CDUSG)检查结果与血清肿瘤标记物(STM)阴性的睾丸小肿块(SmTM)相关联。材料和方法:对2010年1月至2021年1月期间接受睾丸根治性切除术治疗经CDUSG检测到的睾丸内实体性病变的男性患者(n=98)进行回顾性评估。所有患者均根据年龄、睾丸萎缩、回声、肿瘤病变大小、睾丸触诊能力、术前STM和术后病理结果进行评估。结果:58例(59.2%)患者术前至少有一种STM表达升高。术后仍有25例(25.5%)患者出现STM升高;81例(82.7%)患者有恶性病理表现。患者平均年龄为39.47±15.20岁,而良性病变患者的平均年龄高于恶性病变患者(p=0.008)。恶性病变的平均大小显著大于良性病变(5.4vs 3.5cm;p=0.033)。统计上,STM升高,年龄降低,CDUSG异质性,发现大的病变大小是预测恶性肿瘤的参数。虽然20例STM阴性患者中有9例(45%)病变小于3cm为良性,但8例STM阳性患者中有6例(75%)病变小于1.5cm为良性。特别是在患有SmTM的STM阴性患者中,CDUSG可以合理地指导决策阶段,尽管它不能提供明确的诊断。根治性睾丸切除术是治疗所有睾丸实体病变的传统方法,会导致良性病变患者进行不必要的治疗,因此STM-阴性、无法触及的SmTM应首选睾丸切除术,因为癌症的风险较低。
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引用次数: 0
Mycobacterium bovis Associated Aneurysm of the Common Iliac Artery After Bacillus Calmette-Guérin Intravesical Treatment for Urothelial Carcinoma 卡介苗-谷氨酰胺膀胱内治疗尿路上皮癌后髂总动脉牛分枝杆菌相关性动脉瘤
IF 0.3 Q4 UROLOGY & NEPHROLOGY Pub Date : 2022-12-01 DOI: 10.4274/jus.galenos.2022.2021.0122
D. Voci, N. Kucher, A. Zimmermann, S. Barco
A 54-year-old man with a non-invasive urothelial carcinoma (T1N0M0) was scheduled for transurethral resection after a 2-year treatment with adjuvant Bacillus CalmetteGuérin (BCG) instillation therapy. During this period, the patient received antibiotic therapy (Rifampicin, Isoniazid, Ethambutol) for a suspected Mycobacterium bovis systemic infection with B symptoms and lymphadenopathy. A culture of Mycobacterium bovis BCG grew from the sputum of the patient. The preoperative computed tomography (CT) showed an aneurysm of the left common iliac artery with a diameter of approximately 3.5 cm (Figure 1) and a dissection of the right common iliac artery (Figure 2). These findings had not been documented in a previous CT scan done 8 months before. The clinical and imaging findings were consistent with those of a BCG-associated mycotic aneurysm. A xenopericardial graft replacement via midline laparotomy was performed two days after diagnosis without complications. A Ziehl-Neelson staining procedure and a polymerase chain reaction (IS6110 and M65 methods) were performed on an intraoperative tissue sample and confirmed the diagnosis. The patient could be discharged home a few days after the procedure with the same established preoperative antibiotic therapy. After consultation with the infectiologists in the domo, the patient was recommended to continue the antibiotic therapy for another 4 months.
一例54岁男性非侵袭性尿路上皮癌(T1N0M0)在接受辅助卡介苗(BCG)灌注治疗2年后,计划经尿道切除。在此期间,患者接受了抗生素治疗(利福平、异烟肼、乙胺丁醇),以治疗疑似牛分枝杆菌全身感染,伴有B型症状和淋巴结病。病人的痰中培养出牛分枝杆菌卡介苗。术前CT显示左侧髂总动脉动脉瘤,直径约3.5 cm(图1),右侧髂总动脉夹层(图2)。这些发现在8个月前的CT扫描中未见记录。临床和影像学表现与bcg相关的真菌性动脉瘤一致。诊断后2天通过中线剖腹行异种心包置换术,无并发症。对术中组织样本进行Ziehl-Neelson染色和聚合酶链反应(IS6110和M65方法)并确认诊断。患者可在手术后几天出院回家,并采用相同的术前抗生素治疗。在与domo的感染专家会诊后,建议患者继续抗生素治疗4个月。
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引用次数: 0
Specific Effects of Some Metabolic Syndrome Components on Kidney Stone Formation: A Multicentric Multidisciplinary Study 某些代谢综合征成分对肾结石形成的特异性影响:一项多中心多学科研究
IF 0.3 Q4 UROLOGY & NEPHROLOGY Pub Date : 2022-12-01 DOI: 10.4274/jus.galenos.2022.2021.0119
Batuhan Ergani, H. Türk, Mustafa Karabıçak, H. Yılmaz
Kidney stones can develop because of specific changes in the kidney tissue due to various diseases such as type 2 diabetes, hypertension, metabolic syndrome, and non-alcoholic fatty liver. Particularly, a triple mechanism is recognized between metabolic syndrome, non-alcoholic fatty liver disease and syndrome, and atherosclerosis the formation of kidney stones. To our results; triglyceride level and waist circumference were found to have a statistically significant effect on kidney stone formation. The formation of kidney stones caused by these risk factors in the patient can be prevented by eliminating these factors through preventable or treatable modifications.
肾结石的发生是由于各种疾病如2型糖尿病、高血压、代谢综合征和非酒精性脂肪肝引起的肾组织的特殊变化。特别是,代谢综合征、非酒精性脂肪性肝病和综合征与动脉粥样硬化形成肾结石之间存在三重机制。我们的结果;甘油三酯水平和腰围对肾结石的形成有显著的影响。由这些危险因素引起的肾结石的形成可以通过可预防或可治疗的改变来消除这些因素。
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引用次数: 0
Multidisciplinary Collaborative Operations of Urology and Other Surgical Specialties: Thirteen Years of Experience at a Single Center 泌尿外科和其他外科专业的多学科合作手术:在单一中心的十三年经验
IF 0.3 Q4 UROLOGY & NEPHROLOGY Pub Date : 2022-12-01 DOI: 10.4274/jus.galenos.2022.2021.0136
Ubeyd Sungur, H. Polat, Habip Yılmaz, Ekrem Güner
The multidisciplinary evaluation is known be an essential component of today’s medical practice. The urology department requires to be in communication with other surgical branches throughout the preoperative, intraoperative and postoperative periods due to the close neighboring of numerous organs and iatrogenic injuries. This is the first study in the literature to present a review of cases in which multidisciplinary surgeries were performed with the involvement of urology and other surgical specialties.
多学科评估被认为是当今医疗实践的重要组成部分。由于泌尿外科脏器众多,医源性损伤多,需要在术前、术中、术后与其他外科部门保持沟通。这是文献中第一个对涉及泌尿外科和其他外科专业的多学科手术病例进行回顾的研究。
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引用次数: 0
External Validation of CHOKAI and STONE Scores for Detecting Ureter Stones in the Eastern Turkish Population CHOKAI和STONE评分在东土耳其人群中检测输尿管结石的外部验证
IF 0.3 Q4 UROLOGY & NEPHROLOGY Pub Date : 2022-12-01 DOI: 10.4274/jus.galenos.2022.2022.0036
F. Ok, Emrullah Durmuş
Objective: To investigate the effectiveness of CHOKAI and STONE scoring systems in predicting ureter stones in patients admitted to emergency and urology departments. Materials and Methods: This was a single-center prospective observational study. Patients over the age of 18 years with back, flank, or lower abdominal pain and suspected of ureteral stones and performed non-contrast abdominal computed tomography for diagnostic imaging were included. Each patient’s CHOKAI and STONE score was calculated on their medical interviews and physical and laboratory findings. Receiver operating characteristic analysis was used for the sensitivity and specificity of the scoring systems at optimal cut-off values. Results: Of the 348 patients in the study, 228 were detected with ureteral stones. For the CHOKAI score, the area under the curve (AUC) at an optimal cut-off point of 8 was 0.923 [95% confidence interval (CI), 0.894-0.952], with a sensitivity of 0.842, and specificity of 0.975, a positive likelihood ratio (LR+) of 33.68, and a negative likelihood ratio (LR-) 0.162. For the STONE score, the AUC at an optimal cut-off point of 9 was 0.847 (95% CI, 0.807-0.887), with a sensitivity of 0.697 and specificity of 0.900, an LR+ of 6.97, and an LR- 0.336. Conclusion: The CHOKAI score is more sensitive and specific than the STONE score in predicting ureteral stones. Using the CHOKAI score in routine practice will reduce radiation exposure and cost and prevent time loss for serious differential diagnosis.
目的:探讨CHOKAI和STONE评分系统预测急诊和泌尿外科患者输尿管结石的有效性。材料和方法:这是一项单中心前瞻性观察性研究。包括年龄超过18岁、背部、腹部或下腹疼痛、怀疑有输尿管结石并进行非对比腹部计算机断层扫描进行诊断成像的患者。每位患者的CHOKAI和STONE评分是根据他们的医学访谈、身体和实验室检查结果计算得出的。受试者操作特征分析用于评分系统在最佳截止值下的敏感性和特异性。结果:在本研究的348名患者中,228人被检测出输尿管结石。对于CHOKAI评分,最佳截止点8的曲线下面积(AUC)为0.923[95%置信区间(CI),0.894-0.952],敏感性为0.842,特异性为0.975,正似然比(LR+)为33.68,负似然比(LR-)为0.162。对于STONE评分,最佳截止点9的AUC为0.847(95%CI,0.807-0.887),敏感性为0.697,特异性为0.900,LR+为6.97,LR-0.336。结论:CHOKAI评分在预测输尿管结石方面比STONE评分更为敏感和特异。在常规实践中使用CHOKAI评分将减少辐射暴露和成本,并防止严重鉴别诊断的时间损失。
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引用次数: 0
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Journal of Urological Surgery
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