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Host Immune Response to Malaria 宿主对疟疾的免疫反应
Pub Date : 2021-07-28 DOI: 10.33086/iimj.v2i2.1681
Reqgi First Trasia
Malaria is still a health threat, especially for children and pregnant women in endemic areas. The World Health Organization (WHO) reports 228 million cases of malaria occur worldwide and an estimated 405,000 deaths from malaria globally in 2018. A series of malaria control efforts according to WHO recommendations have been carried out widely. However, these programs face obstacles. Therefore, the existence of an effective malaria vaccine is absolutely necessary in a series of malaria control strategies. Development of a malaria vaccine requires a basic concept regarding the host's immune response to malaria. Unfortunately, only a few in Indonesia have reviewed how the immune response is. This article will present an understanding of how the human immune system responds to Plasmodium falciparum.
疟疾仍然是一种健康威胁,特别是对流行地区的儿童和孕妇。世界卫生组织(世卫组织)报告称,2018年全球发生2.28亿例疟疾病例,估计有40.5万人死于疟疾。根据世卫组织的建议,已广泛开展了一系列疟疾控制工作。然而,这些项目面临障碍。因此,在一系列疟疾控制战略中,有效疟疾疫苗的存在是绝对必要的。疟疾疫苗的开发需要一个关于宿主对疟疾免疫反应的基本概念。不幸的是,印度尼西亚只有少数人审查了免疫反应的情况。本文将介绍人类免疫系统对恶性疟原虫的反应。
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引用次数: 0
Exploring Past, Present and Future of Orthotics and Prosthetics in Pakistan 探索巴基斯坦矫形术和假肢的过去、现在和未来
Pub Date : 2021-07-28 DOI: 10.33086/iimj.v2i2.1883
Maria Liaqat, Saima Shaukat, M. Babur
This is a qualitative study to explore the perception of Orthotists and Prosthetists regarding past, present and future of their profession. The Qualitative research approach using individual interviews. Data was collected from professionals of some private and some government sector in Rawalpindi, Peshawar and Lahore during April 2019 to July 2019. The sample size was 12. A demographic questionnaire and standarized instrument from Nvivo was filled satisfying the inclusion criteria. A comprehensive audio-videography have been developed, recorded, transcripted and documented. Data was transcribed and thematic analysis along with characteristics was drawn manually. Data verification was done with the help of coders. After the extraction of data followings results are emerged.  General category themes are trainings and seminars, opportunities, government setup, lack of coherence among professionals, uniform curriculum, and establishment of council, effects of earthquake, German contribution and techniques/technology. Barriers are identified at the level are lack of awareness/ acknowledgement, low job opportunities, no proper workshops, poor referral system, limited resources and old technologies. It is concluded that the field of orthotics and prosthetics in Pakistan need attention in the following categories i.e. trainings and seminars, job opportunities, uniform curriculum, unity among professionals, establishment of council, acknowledgment at government level and awareness among other health professionals.
这是一项质性研究,旨在探讨矫形师和义肢师对其职业的过去、现在和未来的看法。使用个体访谈的定性研究方法。数据是在2019年4月至2019年7月期间从拉瓦尔品第、白沙瓦和拉合尔的一些私营部门和一些政府部门的专业人员中收集的。样本量为12。填写Nvivo的人口统计问卷和标准化仪器,满足纳入标准。已编制、记录、抄写和记录了一套全面的视听录像系统。对数据进行转录,并手工绘制专题分析和特征。数据验证是在编码人员的帮助下完成的。数据提取后得到如下结果:一般类别的主题是培训和研讨会,机会,政府设置,专业人员之间缺乏一致性,统一课程,建立理事会,地震的影响,德国的贡献和技术/技术。在这一级确定的障碍是缺乏认识/承认、低就业机会、没有适当的讲习班、差的转诊制度、有限的资源和陈旧的技术。结论是,巴基斯坦的矫形术和假肢领域需要注意以下几方面,即培训和研讨会、就业机会、统一课程、专业人员之间的团结、建立理事会、政府一级的认可和其他卫生专业人员的认识。
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引用次数: 1
Clinical Characteristic of Congenital Fetal Anomaly In Tertiary Referral Hospital in East Java, Indonesia 印度尼西亚东爪哇三级转诊医院先天性胎儿异常的临床特征
Pub Date : 2021-07-28 DOI: 10.33086/iimj.v2i2.1624
F. Amani, P WardhanaM., I CinintaN., A AryanandaR., E GumilarK., I AldikaM., B. Wicaksono, E. Ernawati, A. Sulistyono, Aditiawarman Aditiawarman, J HermantoT., Nadir Abdullah, G DachlanE
Background: Congenital fetal anomalies were defined as any structural defect present at birth. Congenital fetal anomalies are an important causes of neonatal morbidity and mortality in developed and developing countries that affect health care system. Reliable data on these congenital anomalies are still lacking, especially in Indonesia. Objective: This study aims to determine the characteristic profile of congenital fetal anomaly in single tertiary hospital in East Java, Indonesia. Methods: Retrospective cross-sectional by using medical record data of dr. Soetomo General Hospital on January – December 2017. Results: There were 58 cases (4,3%) with fetal congenital anomaly from 1360 deliveries in 2017. The majority of cases were referral cases (51 cases; 88%) and only seven cases were booked cases in obstetric outpatient dr. Soetomo General Hospital. Most of these congenital fetal anomaly cases ( 25 cases / 43,1%) were born from mother with ages 20 – 30 years old. Most cases (34 cases; 58,64%) were diagnosed first at third trimester (gestational age > 28 weeks). There were 36 cases (62%) had active termination of pregnancy. Thirty eight percent (22 cases) were born at 37-42 weeks and majority were born section caesaria. The three highest proportion of organ systems involved in fetal congenital anomalies were those of abdomen (22 cases; 37,9%); head (20 cases; 34,5%); thorax and muskuloskeletal (each 12 cases; 20,7%). Conclusion: The incidence of congenital fetal anomaly in dr. Soetomo Hospital at 2017 was 4,3%. Omphalocele and CTEV were two most common types of congenital fetal anomaly found. Most cases of congenital fetal anomalies have a poor prognosis, 67% cases born died. Further research about  risk factors and comprehensive database are needed on cases of congenital anomaly to establish appropriate prevention and management.
背景:先天性胎儿畸形被定义为出生时存在的任何结构性缺陷。先天性胎儿畸形是影响发达国家和发展中国家卫生保健系统的新生儿发病率和死亡率的重要原因。关于这些先天性异常的可靠数据仍然缺乏,特别是在印度尼西亚。目的:本研究的目的是确定先天性胎儿畸形在单一三级医院在东爪哇,印度尼西亚的特点。方法:回顾性横断面分析苏东莫总医院2017年1 - 12月病案资料。结果:2017年1360例分娩中胎儿先天性异常58例(4.3%)。大多数病例是转介病例(51例;88%),只有7例是Soetomo综合医院产科门诊预约病例。这些先天性胎儿异常病例(25例/ 43.1%)大多是20 - 30岁的母亲所生。多数病例(34例;58(64%)在妊娠晚期(胎龄> 28周)首次确诊。主动终止妊娠36例(62%)。38%(22例)在37-42周出生,多数为剖宫产。胎儿先天性畸形受累比例最高的三个器官系统是腹部(22例;37岁的9%);头部(20例;34岁的5%);胸、骨骼肌各12例;20日,7%)。结论:2017年Soetomo医生医院先天性胎儿畸形发生率为4.3%。脐膨出和CTEV是两种最常见的先天性胎儿畸形。多数先天性胎儿畸形预后较差,67%的新生儿死亡。需要进一步研究先天性异常的危险因素,建立全面的病例数据库,以制定相应的预防和管理措施。
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引用次数: 2
Characteristic of Pregnancy in Woman with Rheumatic Mitral Stenosis in Dr. Soetomo Hospital Surabaya from 2015 – 2017 2015 - 2017年泗水Soetomo医生医院风湿性二尖瓣狭窄患者妊娠特征分析
Pub Date : 2021-07-26 DOI: 10.33086/IIMJ.V2I1.1589
J. Relmasira, B. Wicaksono
Background: Cardiac disease is 1 of the major causes of maternal mortality. Mitral Stenosis (MS) is a particularly high-risk condition for a pregnant woman in emerging countries, the main cause of MS is a complication from rheumatic heart disease. Objective: To study the maternal and perinatal outcome of pregnancies complicated by mitral stenosis from rheumatic heart disease. Methods: We conduct a cross-sectional retrospective study using electronic medical data records in dr. Soetomo General Hospital over the period of 3 years from 2015 – 2017 involving 36 cases of pregnant women complicated by rheumatic mitral stenosis. The maternal and perinatal outcome was reviewed. Result: Most of the pregnant women with rheumatic mitral stenosis were at 29 - 34 weeks of gestational age. Majority of the patient (61,1 %) was in NYHA II classification for heart failure degree. The Degree of MS was moderate (75 %) and severe (25 %), with a maternal mortality rate was 4/36 patients (11,1 %), and all of the patients were with severe MS had class III/IV heart failure. The main reason for hospital admission was heart failure (50 %). 38 % of women with NYHA Class III/IV had severe MS. Most accompanying valve diseases occur at the patient with severe MS, with Tricuspid Regurgitation as the most accompanying valve disease (66,67 %) followed by Mitral Regurgitation (36,11 %) and Aortic Regurgitation (25 %). Percutaneous Transmitral Valve Commissurotomy (PTMC) was the chosen surgical intervention for valve correction. For a patient with Moderate MS, 6/8 (75 %) of the pregnancy terminated at ³ 34 weeks of gestational age, compared with 18/28 (64,28 %) patient with Severe MS the pregnancy terminated at < 34 weeks of gestational age. Cesarean section was the most chosen method of delivery for most of the cases. Fetal weight (4/7 cases) at delivery for Moderate MS was > 2500 g, compared with (7/18 cases) was < 2000 g for Severe MS. APGAR Score for Moderate MS cases was 8-10 for 5/7 cases, compared with Severe MS, 16/24 cases were < 8. Conclusions: Cardiac and obstetric complications from rheumatic mitral disease remain a major challenge in this disease. Early diagnosis and management with good adherent to pre-conceptional and prenatal care remain a key factor for preventing maternal and fetal morbidity and mortality.
背景:心脏病是孕产妇死亡的主要原因之一。二尖瓣狭窄(MS)是新兴国家孕妇特别高风险的疾病,MS的主要原因是风湿性心脏病的并发症。目的:探讨风湿性心脏病合并二尖瓣狭窄的妊娠结局及围产儿结局。方法:利用dr. Soetomo综合医院2015 - 2017年3年间的电子医疗数据记录,对36例合并风湿性二尖瓣狭窄的孕妇进行横断面回顾性研究。回顾了产妇和围产期结局。结果:风湿性二尖瓣狭窄以29 ~ 34周妊娠为主。大多数患者(61.1%)心衰程度为NYHA II级。重度MS分为中度(75%)和重度(25%),产妇死亡率为4/36(11.1%),重度MS均为III/IV级心力衰竭。住院的主要原因是心力衰竭(50%)。NYHA III/IV级患者中有38%发生严重MS,大多数并发瓣膜疾病发生在严重MS患者中,三尖瓣反流是最常见的瓣膜疾病(66.67%),其次是二尖瓣反流(36.11%)和主动脉反流(25%)。经皮肾外传瓣膜合并术(PTMC)是矫正瓣膜的首选手术方法。中度多发性硬化症患者中,6/8(75%)的妊娠终止于34周孕龄,而重度多发性硬化症患者中,18/28(64.28%)的妊娠终止于< 34周孕龄。剖宫产是大多数病例中最常用的分娩方式。中度MS分娩时胎重(4/7)> 2500 g,重度MS分娩时胎重(7/18)< 2000 g,中度MS分娩时APGAR评分为8-10(5/7),重度MS分娩时APGAR评分为16/24(8)。结论:风湿性二尖瓣疾病的心脏和产科并发症仍然是该疾病的主要挑战。早期诊断和管理与良好的坚持孕前和产前护理仍然是预防孕产妇和胎儿发病率和死亡率的关键因素。
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引用次数: 0
Effects of Breathing Exercises on Lung Volumes and Capacities Among Smokers 呼吸练习对吸烟者肺容量和容量的影响
Pub Date : 2020-12-30 DOI: 10.33086/IIMJ.V2I1.1829
Iman Zahra, Maria Liaqat, U. Qadeer
Objective: To determine the effect of deep breathing exercises on lung volumes and capacities among smokers. Methodology: The participants were divided into a control group and an experimental group. The control group was not given any treatment, while the experimental group performed deep breathing exercise techniques. The experimental group performed exercises for six weeks. After six weeks lung function tests were performed to evaluate the effects. Data were compared at baseline and after the intervention. To check within the group's changes paired sample t-test was used. To check between groups changes independent sample t-test was used for normally distributed data. Results: In the experimental group, significant changes (p ≤ 0.05) were observed after the intervention. While comparing groups, significant differences (p ≤ 0.05) were observed in some variables between experimental and control groups.Conclusion: It was concluded that deep breathing exercises are useful among smokers. As deep breathing helps in improving lung volumes and capacities.
目的:探讨深呼吸运动对吸烟者肺容量和肺容量的影响。方法:将参与者分为对照组和实验组。对照组不进行任何治疗,实验组进行深呼吸练习。实验组进行为期六周的锻炼。6周后进行肺功能测试以评估效果。将基线和干预后的数据进行比较。为了检查组内的变化,使用配对样本t检验。对于正态分布的数据,采用独立样本t检验来检验组间变化。结果:实验组干预后出现显著变化(p≤0.05)。组间比较,实验组与对照组在部分变量上差异有统计学意义(p≤0.05)。结论:深呼吸练习对吸烟者有益。因为深呼吸有助于提高肺容量和容量。
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引用次数: 0
Body Mass Index and Albumin Level In Severe Preeclampsia Conservative Treatment Cases 重度子痫前期保守治疗的体重指数和白蛋白水平
Pub Date : 2020-09-01 DOI: 10.33086/IIMJ.V1I2.1614
Esmond Winarko, M. Yusuf
Background : Severe preeclampsia is an obstetrical problem and one of the leading cause of death in obstetric. Conservative treatment for severe preeclampsia is a complicated and risky choice, but still a considerable option to achieve a better fetal outcome. Many factors that influence the results of conservative management are complex and still very much controversial. Objective: To study the BMI and albumin level of severe preeclampsia patients who underwent conservative management in dr. Soetomo General Hospital obstetric ward in 2018 – 2019. Method: This is a descriptive cross sectional study, where the data are obtained from morning reports, obstetric ward registry and dr. Soetomo General Hospital medical record during 2018 – 2019. Results: The total conservative cases were 51 in 2018 and 69 in 2019. The majority of the patients were 20-34 years old, multigravida, non-booked cases, Javanese ethnicity, and addressed in Surabaya. Most of them were obese (with BMI ≥ 30 kg/m2) with similar BMI distribution in the successful and unsuccessful conservative management groups. Most of our patients had albumin level below 3,5 g/dl. The majority of the patients were terminated by caesarean section with the fetal outcome mostly weighed less than 2000 g. Conclusion: The majority of the patients treated conservatively were 20-34 years old, multigravida, non-booked cases, Javanese ethnicity, and addressed in Surabaya. Most of the patients have BMI ≥ 30 kg/m2 and albumin levels below 3,5.
背景:重度子痫前期是一种产科疾病,也是产科死亡的主要原因之一。严重子痫前期的保守治疗是一个复杂和危险的选择,但仍然是一个相当大的选择,以获得更好的胎儿结局。许多影响保守管理结果的因素是复杂的,并且仍然非常有争议。目的:研究2018 - 2019年苏东莫综合医院产科病房保守治疗的重度子痫前期患者的BMI和白蛋白水平。方法:这是一项描述性横断面研究,数据来自2018 - 2019年早间报告、产科病房登记和dr. Soetomo总医院的病历。结果:2018年保守病例51例,2019年保守病例69例。大多数患者年龄为20-34岁,多胎,未预约病例,爪哇族,在泗水就诊。保守管理成功组和不成功组以肥胖(BMI≥30 kg/m2)居多,BMI分布相似。大多数患者的白蛋白水平低于3.5 g/dl。多数患者以剖宫产方式终止妊娠,胎儿重量多小于2000克。结论:保守治疗的患者多为20-34岁、多胎、未预约病例、爪哇族、居住在泗水。多数患者BMI≥30 kg/m2,白蛋白水平低于3,5。
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International Islamic Medical Journal
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