Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367635
Nicholas Skapura, Guozhu Dong
Discovering useful patterns in medical time series data such as EEG and EMG recordings is an important step for gaining useful insights into the data and medical problem under investigation, and for building accurate classifiers. However, pattern mining algorithms often require a binning step, which maps the time series data into a representation in terms of discretized values, in order to discover patterns. How the intervals are constructed has a significant impact on the quality of the mined patterns. We propose a novel binning technique, called Distribution Skew-based Binning (or DS Binning), which uses the distribution of the classes associated with the numerical attribute values to construct the intervals. Experiments show that this method outperforms existing binning methods in facilitating the discovery of high quality patterns from multivariate EEG/EMG time series data, leading to higher classification accuracy. Our experiments demonstrate that DS binning can provide approximately a 5-10% improvement in classification accuracy over other binning methods in multiple scenarios.
{"title":"Distribution skew-based binning: Towards mining highly discriminative patterns from EEG/EMG time series","authors":"Nicholas Skapura, Guozhu Dong","doi":"10.1109/BIBE.2015.7367635","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367635","url":null,"abstract":"Discovering useful patterns in medical time series data such as EEG and EMG recordings is an important step for gaining useful insights into the data and medical problem under investigation, and for building accurate classifiers. However, pattern mining algorithms often require a binning step, which maps the time series data into a representation in terms of discretized values, in order to discover patterns. How the intervals are constructed has a significant impact on the quality of the mined patterns. We propose a novel binning technique, called Distribution Skew-based Binning (or DS Binning), which uses the distribution of the classes associated with the numerical attribute values to construct the intervals. Experiments show that this method outperforms existing binning methods in facilitating the discovery of high quality patterns from multivariate EEG/EMG time series data, leading to higher classification accuracy. Our experiments demonstrate that DS binning can provide approximately a 5-10% improvement in classification accuracy over other binning methods in multiple scenarios.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129489345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367699
Jeong-Cheol Lee, I. Song, Suk-Young Kim, S. Rhee
The bioactive and degradable 70poly(50lactic-co-50glycoric acid)/30(60SiO2-40CaO) composite, which had a dual pore structure, was synthesized by a gas expansion method. The bioactive 60SiO2-40CaO powders were prepared through a sol-gel method from tetraethyl orthosilicate and calcium nitrate tetrahydrate under nitric acidic condition followed by the heat treatment at 900°C for 1 h. The 70poly(50lactic-co-50glycoric acid)/30(60SiO2-40CaO) composite was then synthesized by a solvent casting method using 1,1,3,3-hexafluoro-2-propanol as a solvent. The disk-shaped 70poly(50lactic-co-50glycoric acid)/30(60SiO2-40CaO) composite was loaded into the custom-made high-pressure gas chamber and then carbon dioxide gas was introduced until achieving a final pressure of 20 MPa. After 1 day of loading, the carbon dioxide gas was released rapidly. The samples were observed by FE-SEM, the phase was evaluated by X-ray diffractometer, and its bioactivity was assessed in simulated body fluid. As a result, double pore structure was developed in the poly(50lactic-co-50glycoric acid) matrix after releasing the carbon dioxide gas and 60SiO2-40CaO particles were observed to place randomly among the poly(50lactic-co-50glycoric acid) matrix. After soaking in simulated body fluid for 1 week, flake-like low crystalline hydroxyl carbonate apatite was formed on the surface of the composite. The practical implication of the results is that it has promising potential for use as a scaffold material for bone tissue engineering due to its bioactivity and degradability.
{"title":"Synthesis of a bioactive and degradable 70Poly(50Lactic-co-50Glycoric acid)/30(60SiO2-40CaQ) composite with dual pore structure","authors":"Jeong-Cheol Lee, I. Song, Suk-Young Kim, S. Rhee","doi":"10.1109/BIBE.2015.7367699","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367699","url":null,"abstract":"The bioactive and degradable 70poly(50lactic-co-50glycoric acid)/30(60SiO2-40CaO) composite, which had a dual pore structure, was synthesized by a gas expansion method. The bioactive 60SiO2-40CaO powders were prepared through a sol-gel method from tetraethyl orthosilicate and calcium nitrate tetrahydrate under nitric acidic condition followed by the heat treatment at 900°C for 1 h. The 70poly(50lactic-co-50glycoric acid)/30(60SiO2-40CaO) composite was then synthesized by a solvent casting method using 1,1,3,3-hexafluoro-2-propanol as a solvent. The disk-shaped 70poly(50lactic-co-50glycoric acid)/30(60SiO2-40CaO) composite was loaded into the custom-made high-pressure gas chamber and then carbon dioxide gas was introduced until achieving a final pressure of 20 MPa. After 1 day of loading, the carbon dioxide gas was released rapidly. The samples were observed by FE-SEM, the phase was evaluated by X-ray diffractometer, and its bioactivity was assessed in simulated body fluid. As a result, double pore structure was developed in the poly(50lactic-co-50glycoric acid) matrix after releasing the carbon dioxide gas and 60SiO2-40CaO particles were observed to place randomly among the poly(50lactic-co-50glycoric acid) matrix. After soaking in simulated body fluid for 1 week, flake-like low crystalline hydroxyl carbonate apatite was formed on the surface of the composite. The practical implication of the results is that it has promising potential for use as a scaffold material for bone tissue engineering due to its bioactivity and degradability.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132267387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367639
A. Arasteh, B. Vahdat
In this research, a web-based simulator is developed, which can be used for generating image sequences of moving spermatozoa cells. It can be used for assessment of multiple object tracking algorithms, especially Computer Aided Sperm Analysis (CASA) systems. The developed software has many useful parameters such as blurring images or adding noise and it also gives full control of sperm counts and types. To illustrate performance of the developed simulator, three parameters (spermatozoa population, standard deviation of Gaussian blur filter and noise intensity) have been swept and the results of three different multiple object tracking algorithms were compared as an application of this simulation.
{"title":"Multiple cell tracking algorithm assessment using simulation of spermatozoa movement","authors":"A. Arasteh, B. Vahdat","doi":"10.1109/BIBE.2015.7367639","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367639","url":null,"abstract":"In this research, a web-based simulator is developed, which can be used for generating image sequences of moving spermatozoa cells. It can be used for assessment of multiple object tracking algorithms, especially Computer Aided Sperm Analysis (CASA) systems. The developed software has many useful parameters such as blurring images or adding noise and it also gives full control of sperm counts and types. To illustrate performance of the developed simulator, three parameters (spermatozoa population, standard deviation of Gaussian blur filter and noise intensity) have been swept and the results of three different multiple object tracking algorithms were compared as an application of this simulation.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126075060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367678
M. Biler, P. Trouillas
This theoretical contribution provides some important recommendations to evaluate the optical properties of natural polyphenols. UV-Vis absorption spectra can be accurately evaluated using regular hybrid DFT functionals. Non-covalent supramolecular assemblies existing between (anthocyanin) pigments and (phenolic) copigments require dispersion correction (to tackle geometrical features) and long-range corrections (to tackle optical properties and charge transfer excited states).
{"title":"Key issues in computing optical properties of natural polyphenols","authors":"M. Biler, P. Trouillas","doi":"10.1109/BIBE.2015.7367678","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367678","url":null,"abstract":"This theoretical contribution provides some important recommendations to evaluate the optical properties of natural polyphenols. UV-Vis absorption spectra can be accurately evaluated using regular hybrid DFT functionals. Non-covalent supramolecular assemblies existing between (anthocyanin) pigments and (phenolic) copigments require dispersion correction (to tackle geometrical features) and long-range corrections (to tackle optical properties and charge transfer excited states).","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128426803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367688
T. Exarchos, K. Stefanou, G. Rigas, A. Bibas, D. Kikidis, Christos Nikitas, F. Wuyts, Berina Ihtijarevic, L. Maes, Massimo Cenciarini, C. Maurer, D. Iliopoulou, Nora Macdonald, D. Bamiou, L. Luxon, Marios Prasinos, G. Spanoudakis, D. Koutsouris, D. Fotiadis
In this work we present the decision support of the EMBalance platform. EMBalance is a platform for the management of balance disorders in terms of diagnosis, treatment and evolution. The EMBalance platform aims to extend existing but generic and currently uncoupled balance modelling activities leading to a multi-scale and patient-specific balance model, which will be incorporated in a Decision Support System (DSS), towards the early diagnosis, prediction and the efficient treatment planning of balance disorders. The diagnosis part of the decision support system uses various data ranging from demographic characteristics to clinical examinations, auditory and vestibular tests. Currently we present some initial technical choices and indicative results of the decision support system for diagnosing balance disorders, based on data mining techniques and clinical guidelines.
{"title":"Diagnosis of balance disorders using decision support systems based on data mining techniques","authors":"T. Exarchos, K. Stefanou, G. Rigas, A. Bibas, D. Kikidis, Christos Nikitas, F. Wuyts, Berina Ihtijarevic, L. Maes, Massimo Cenciarini, C. Maurer, D. Iliopoulou, Nora Macdonald, D. Bamiou, L. Luxon, Marios Prasinos, G. Spanoudakis, D. Koutsouris, D. Fotiadis","doi":"10.1109/BIBE.2015.7367688","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367688","url":null,"abstract":"In this work we present the decision support of the EMBalance platform. EMBalance is a platform for the management of balance disorders in terms of diagnosis, treatment and evolution. The EMBalance platform aims to extend existing but generic and currently uncoupled balance modelling activities leading to a multi-scale and patient-specific balance model, which will be incorporated in a Decision Support System (DSS), towards the early diagnosis, prediction and the efficient treatment planning of balance disorders. The diagnosis part of the decision support system uses various data ranging from demographic characteristics to clinical examinations, auditory and vestibular tests. Currently we present some initial technical choices and indicative results of the decision support system for diagnosing balance disorders, based on data mining techniques and clinical guidelines.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117081579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367657
P. Bountris, Charalambos Tsirmpas, M. Haritou, A. Pouliakis, Ioannis N. Kouris, P. Karakitsos, D. Koutsouris
In most cases, cervical cancer (CxCa) develops as a result of underestimated abnormalities present in cytology via the test Papanicolaou (Pap test). Although it is the sole test that has proved its value for cancer prevention, Pap test is prone to human errors as it is performed via the microscope and requires skilled personnel. Consequently, molecular techniques have emerged in the recent years, aiming to replace Pap test or support the diagnosis as ancillary tests. These include DNA micro-arrays identifying Human Papillomavirus (HPV) subtypes, mRNA techniques such as nucleic acid based amplification or flow cytometry identifying E6/E7 oncogenes, and immunocytochemistry techniques such as overexpression of p16. These techniques are either highly sensitive or highly specific, but not both at the same time, thus no perfect method is available today. Moreover, most of the published studies compare two tests against each other, which, however, are using different population study groups, therefore it is questionable if the results can be used to perform a direct comparison between the available tests. In this paper, we adopt a sophisticated approach to assess the value of several well-known and widely applied CxCa tests in detecting high-grade cervical intraepithelial neoplasia and CxCa (CIN2+), by employing an Ensemble Feature Ranking framework. Applying the proposed framework we managed to directly compare and rank the studied CxCa tests and several HPV genotypes according to their efficacy in detecting CIN2+ lesions. The results suggest that HPV mRNA tests perform better than HPV DNA testing for the triage of abnormal Pap tests. Such findings may guide cytopathologists in a step by step basis to decide which tests to perform following an abnormal Pap test, in order to decrease uncertainty, improve accuracy and reduce time to diagnosis and resources.
{"title":"An ensemble feature ranking framework for the assessment of the efficacy of cervical cancer detection tests and human papillomavirus genotypes in the detection of high-grade cervical intraepithelial neoplasia and cervical carcinoma","authors":"P. Bountris, Charalambos Tsirmpas, M. Haritou, A. Pouliakis, Ioannis N. Kouris, P. Karakitsos, D. Koutsouris","doi":"10.1109/BIBE.2015.7367657","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367657","url":null,"abstract":"In most cases, cervical cancer (CxCa) develops as a result of underestimated abnormalities present in cytology via the test Papanicolaou (Pap test). Although it is the sole test that has proved its value for cancer prevention, Pap test is prone to human errors as it is performed via the microscope and requires skilled personnel. Consequently, molecular techniques have emerged in the recent years, aiming to replace Pap test or support the diagnosis as ancillary tests. These include DNA micro-arrays identifying Human Papillomavirus (HPV) subtypes, mRNA techniques such as nucleic acid based amplification or flow cytometry identifying E6/E7 oncogenes, and immunocytochemistry techniques such as overexpression of p16. These techniques are either highly sensitive or highly specific, but not both at the same time, thus no perfect method is available today. Moreover, most of the published studies compare two tests against each other, which, however, are using different population study groups, therefore it is questionable if the results can be used to perform a direct comparison between the available tests. In this paper, we adopt a sophisticated approach to assess the value of several well-known and widely applied CxCa tests in detecting high-grade cervical intraepithelial neoplasia and CxCa (CIN2+), by employing an Ensemble Feature Ranking framework. Applying the proposed framework we managed to directly compare and rank the studied CxCa tests and several HPV genotypes according to their efficacy in detecting CIN2+ lesions. The results suggest that HPV mRNA tests perform better than HPV DNA testing for the triage of abnormal Pap tests. Such findings may guide cytopathologists in a step by step basis to decide which tests to perform following an abnormal Pap test, in order to decrease uncertainty, improve accuracy and reduce time to diagnosis and resources.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131268704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367666
I. Končar, M. Sladojevic, D. Nikolić, Z. Milosevic, M. Dragaš, I. Banzić, M. Marković, N. Filipovic, L. Davidovic
The role of intraluminal thrombus (ILT) has special attention in these studies. One of the papers showed that asymmetrical intraluminal thrombus deposition (ATDI) has an important role in growth of the AAA. The aim of our study was to assess the asymmetrical thrombus deposition index in ruptured and symptomatic aneurysms. We collected data for 33 aneurysms, 21 (63.63%) asymptomatic and 12 (33.37%) ruptured or symptomatic. Asymmetrical thrombus deposition index (ATDI) was measured by Onis DICOM viewer software. Also, lumen's geometrical centre (LGC) was defined and ATDI was considered positive when the LGC was laid on the posterior section of the sac (meaning dominant anterior ILT distribution) and negative when it was laid on the anterior section (meaning dominant posterior ILT distribution). Maximum aneurysm diameter was 63.4mm in average (50-100mm, SD=12.89); 59.8mm in asymptomatic and 71.16mm in symptomatic or ruptured aneurysm (p=0.012). The absolute value of asymmetric thrombus deposition index was significantly higher in symptomatic/ruptured compared to asymptomatic aneurysm, 0.54 and 0.33, respectively (p=0.041), while there was no difference in frequency of positive or negative thrombus deposition (p=0.261). There was no significant correlation between maximal aneurysm size and absolute value of ATDI (p=0.505). Values of thrombus deposition index are correlating with the development of symptomatology or rupture of the AAA. This variable should be included in much wider mathematical rupture prediction model in order to have more accurate rupture risk assessment.
{"title":"Intraluminal thrombus asymmetrical deposition in ruptured and symptomatic abdominal aortic aneurysm","authors":"I. Končar, M. Sladojevic, D. Nikolić, Z. Milosevic, M. Dragaš, I. Banzić, M. Marković, N. Filipovic, L. Davidovic","doi":"10.1109/BIBE.2015.7367666","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367666","url":null,"abstract":"The role of intraluminal thrombus (ILT) has special attention in these studies. One of the papers showed that asymmetrical intraluminal thrombus deposition (ATDI) has an important role in growth of the AAA. The aim of our study was to assess the asymmetrical thrombus deposition index in ruptured and symptomatic aneurysms. We collected data for 33 aneurysms, 21 (63.63%) asymptomatic and 12 (33.37%) ruptured or symptomatic. Asymmetrical thrombus deposition index (ATDI) was measured by Onis DICOM viewer software. Also, lumen's geometrical centre (LGC) was defined and ATDI was considered positive when the LGC was laid on the posterior section of the sac (meaning dominant anterior ILT distribution) and negative when it was laid on the anterior section (meaning dominant posterior ILT distribution). Maximum aneurysm diameter was 63.4mm in average (50-100mm, SD=12.89); 59.8mm in asymptomatic and 71.16mm in symptomatic or ruptured aneurysm (p=0.012). The absolute value of asymmetric thrombus deposition index was significantly higher in symptomatic/ruptured compared to asymptomatic aneurysm, 0.54 and 0.33, respectively (p=0.041), while there was no difference in frequency of positive or negative thrombus deposition (p=0.261). There was no significant correlation between maximal aneurysm size and absolute value of ATDI (p=0.505). Values of thrombus deposition index are correlating with the development of symptomatology or rupture of the AAA. This variable should be included in much wider mathematical rupture prediction model in order to have more accurate rupture risk assessment.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114371883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367693
D. Zlenko, P. Krasilnikov, I. Stadnichuk
Using methods of molecular modeling, we have derived a universal spatial model of the orange carotenoid protein (OCP) and phycobilisome (PBS) core interaction in process of energy excess dissipation. The protrusion of the phy-cobilin domain (PB) of the core-membrane linker polypeptide (Lcm) forms the interaction site for the OCP central cavity on the PBS core surface. This spatial arrangement has to be the most advantageous one because the LCM, as the major terminal PBS-fluorescence emitter, gathers energy from the other phycobiliproteins within the PBS before quenching by OCP. In agreement with the constructed model, the small fluorescence recovery protein (FRP) also interacts with the OCPs central cavity weakening the PBS and OCP binding.
{"title":"Interaction of the orange carotenoid protein with the phycobilisome core and fluorescence recovery protein","authors":"D. Zlenko, P. Krasilnikov, I. Stadnichuk","doi":"10.1109/BIBE.2015.7367693","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367693","url":null,"abstract":"Using methods of molecular modeling, we have derived a universal spatial model of the orange carotenoid protein (OCP) and phycobilisome (PBS) core interaction in process of energy excess dissipation. The protrusion of the phy-cobilin domain (PB) of the core-membrane linker polypeptide (Lcm) forms the interaction site for the OCP central cavity on the PBS core surface. This spatial arrangement has to be the most advantageous one because the LCM, as the major terminal PBS-fluorescence emitter, gathers energy from the other phycobiliproteins within the PBS before quenching by OCP. In agreement with the constructed model, the small fluorescence recovery protein (FRP) also interacts with the OCPs central cavity weakening the PBS and OCP binding.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129284151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367682
Z. Milosevic, D. Nikolić, I. Šaveljić, Milos D. Radovic, V. Isailović, N. Zdravković, N. Filipovic
Benign paroxysmal positional vertigo (BPPV) is the most commonly diagnosed vertigo syndrome that affects 15% of older persons. BPPV is characterized by sudden attacks of dizziness and nausea triggered by changes in head orientation, and primarily afflicts the posterior canal. We are modeling human semicircular canals (SSC) which considers the morphology of the organs and the composition of the biological tissues and their viscoelastic and mechanical properties. The Navier-Stokes equations of balance of linear momentum and the continuity equation with application of Penalty method are used. For fluid-structure interaction problem we use loose coupling methodology with ALE (Arbitrary Lagrangian Eulerian) formulation. The tissue of SSC has nonlinear constitutive laws, leading to materially-nonlinear finite element formulation. The incremental-iterative equation is using for nonlinear wall tissue problem. Our results simulate many dynamics position of head and dynamic fluid parameters, shear stress, effective wall stress of membrane. This could help in better diagnostic and therapy process for BPPV disease.
{"title":"Computer modeling of semicircular canals in the vestibular system","authors":"Z. Milosevic, D. Nikolić, I. Šaveljić, Milos D. Radovic, V. Isailović, N. Zdravković, N. Filipovic","doi":"10.1109/BIBE.2015.7367682","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367682","url":null,"abstract":"Benign paroxysmal positional vertigo (BPPV) is the most commonly diagnosed vertigo syndrome that affects 15% of older persons. BPPV is characterized by sudden attacks of dizziness and nausea triggered by changes in head orientation, and primarily afflicts the posterior canal. We are modeling human semicircular canals (SSC) which considers the morphology of the organs and the composition of the biological tissues and their viscoelastic and mechanical properties. The Navier-Stokes equations of balance of linear momentum and the continuity equation with application of Penalty method are used. For fluid-structure interaction problem we use loose coupling methodology with ALE (Arbitrary Lagrangian Eulerian) formulation. The tissue of SSC has nonlinear constitutive laws, leading to materially-nonlinear finite element formulation. The incremental-iterative equation is using for nonlinear wall tissue problem. Our results simulate many dynamics position of head and dynamic fluid parameters, shear stress, effective wall stress of membrane. This could help in better diagnostic and therapy process for BPPV disease.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130307736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367627
S. Mayya, Vivek Jilla, V. N. Tiwari, Mithun M. Nayak, R. Narayanan
Continuous monitoring of an individual's stress levels is essential to manage stress and mental state in an effective way. With increasing ubiquity of wearable heart rate monitors and their unobtrusiveness, HRV (Heart rate variability) derived from heart rate signals has emerged as one of the most relevant parameters for continuous monitoring of stress. In the present work, we have made an attempt to address the challenges about distinguishing between stressed and non-stressed state of a person based on just one minute of IBI (Inter Beat Interval) records with good accuracy. Such ultra-short term analysis of HRV is particularly advantageous towards capturing very short term fluctuations in mental stress levels and enhanced scope for frequent monitoring. We have analyzed various time domain, frequency domain and nonlinear HRV features to narrow down to a most influential set of features for accurate classification between stressed and non-stressed state. We have identified RMSSD (root mean square of successive differences) of IBI series to be the most direct indicator of stressed state. We also provide a continuous stress score which, when used in continuous monitoring scenario, provides the user with adequate details about his/her stress levels. This helps the user to understand stress patterns across a day in a better way and to take appropriate measures to manage stressful situations. We have developed and deployed a system, based on above concept, on smartphone as an android application for real-time stress monitoring.
{"title":"Continuous monitoring of stress on smartphone using heart rate variability","authors":"S. Mayya, Vivek Jilla, V. N. Tiwari, Mithun M. Nayak, R. Narayanan","doi":"10.1109/BIBE.2015.7367627","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367627","url":null,"abstract":"Continuous monitoring of an individual's stress levels is essential to manage stress and mental state in an effective way. With increasing ubiquity of wearable heart rate monitors and their unobtrusiveness, HRV (Heart rate variability) derived from heart rate signals has emerged as one of the most relevant parameters for continuous monitoring of stress. In the present work, we have made an attempt to address the challenges about distinguishing between stressed and non-stressed state of a person based on just one minute of IBI (Inter Beat Interval) records with good accuracy. Such ultra-short term analysis of HRV is particularly advantageous towards capturing very short term fluctuations in mental stress levels and enhanced scope for frequent monitoring. We have analyzed various time domain, frequency domain and nonlinear HRV features to narrow down to a most influential set of features for accurate classification between stressed and non-stressed state. We have identified RMSSD (root mean square of successive differences) of IBI series to be the most direct indicator of stressed state. We also provide a continuous stress score which, when used in continuous monitoring scenario, provides the user with adequate details about his/her stress levels. This helps the user to understand stress patterns across a day in a better way and to take appropriate measures to manage stressful situations. We have developed and deployed a system, based on above concept, on smartphone as an android application for real-time stress monitoring.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130475191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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