Pub Date : 2018-07-01DOI: 10.4103/ijdpdd.ijdpdd_37_17
Preema Sinha, P. Singh, Arijit Sen, A. Sood
Orofacial granulomatosis (OFG) comprises a group of diseases characterized by noncaseating granulomatous inflammation affecting the soft tissues of the oral and maxillofacial region. The classic presentation of OFG is a nontender recurrent labial swelling that eventually becomes persistent; however, the clinical presentation can be highly variable, making the diagnosis difficult to establish. Herein, we report the rare case of a 15-year-old patient, suffering from OFG and discoid lupus erythematosus; this coexistence of two such rare entities together hardly finds a mention in the literature.
{"title":"Coexisting orofacial granulomatosis with discoid lupus erythematosus: Report of a rare case","authors":"Preema Sinha, P. Singh, Arijit Sen, A. Sood","doi":"10.4103/ijdpdd.ijdpdd_37_17","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_37_17","url":null,"abstract":"Orofacial granulomatosis (OFG) comprises a group of diseases characterized by noncaseating granulomatous inflammation affecting the soft tissues of the oral and maxillofacial region. The classic presentation of OFG is a nontender recurrent labial swelling that eventually becomes persistent; however, the clinical presentation can be highly variable, making the diagnosis difficult to establish. Herein, we report the rare case of a 15-year-old patient, suffering from OFG and discoid lupus erythematosus; this coexistence of two such rare entities together hardly finds a mention in the literature.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"58 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123223256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.4103/ijdpdd.ijdpdd_22_18
Aida Valencia-Guerrero, K. Dresser, K. Cornejo
Dermatitis herpetiformis (DH), also known as Duhring-Brocq dermatitis, is an autoimmune, chronic subepidermal blistering disorder characterized by an intensely pruritic, papulovesicular eruption. It is linked to gluten sensitivity and considered to be a cutaneous manifestation of celiac disease. It has been demonstrated that sera from most patients with DH demonstrate autoantibodies against epidermal transglutaminase (eTG) and tissue transglutaminase (tTG). Therefore, the aim of the study was to evaluate the diagnostic utility of eTG and tTG immunohistochemistry in identifying patients with DH. A total of 15 skin biopsies from patients with an established diagnosis of DH confirmed by histopathology and direct immunofluorescence (DIF) studies were evaluated. Six cases were used as controls in which the clinical differential included DH and were found to be nondiagnostic by both histopathology and DIF evaluations. Eight (55%) of the DH cases were positive for eTG expression, while none of the controls showed any immunoreactivity (P = 0.0456). All 15 (100%) DH cases showed faint granular staining for tTG in the epidermal basal layers with similar results in all 6 (100%) control cases. Our study indicates eTG immunohistochemistry may aid in identifying patients with DH, with a diagnostic sensitivity and specificity of 55% and 100%, respectively. tTG does not appear to be a useful immunomarker in this setting.
{"title":"The utility of tissue and epidermal transglutaminase immunohistochemistry in dermatitis herpetiformis","authors":"Aida Valencia-Guerrero, K. Dresser, K. Cornejo","doi":"10.4103/ijdpdd.ijdpdd_22_18","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_22_18","url":null,"abstract":"Dermatitis herpetiformis (DH), also known as Duhring-Brocq dermatitis, is an autoimmune, chronic subepidermal blistering disorder characterized by an intensely pruritic, papulovesicular eruption. It is linked to gluten sensitivity and considered to be a cutaneous manifestation of celiac disease. It has been demonstrated that sera from most patients with DH demonstrate autoantibodies against epidermal transglutaminase (eTG) and tissue transglutaminase (tTG). Therefore, the aim of the study was to evaluate the diagnostic utility of eTG and tTG immunohistochemistry in identifying patients with DH. A total of 15 skin biopsies from patients with an established diagnosis of DH confirmed by histopathology and direct immunofluorescence (DIF) studies were evaluated. Six cases were used as controls in which the clinical differential included DH and were found to be nondiagnostic by both histopathology and DIF evaluations. Eight (55%) of the DH cases were positive for eTG expression, while none of the controls showed any immunoreactivity (P = 0.0456). All 15 (100%) DH cases showed faint granular staining for tTG in the epidermal basal layers with similar results in all 6 (100%) control cases. Our study indicates eTG immunohistochemistry may aid in identifying patients with DH, with a diagnostic sensitivity and specificity of 55% and 100%, respectively. tTG does not appear to be a useful immunomarker in this setting.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129325865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.4103/ijdpdd.ijdpdd_63_18
Kristofer Holte, A. Biswas
There has been relatively little change during the past four decades in the way dermatopathologists approach and interpret biopsies obtained from inflammatory skin disorders. If anything, there has been a stronger emphasis on clinicopathologic correlation as an aid to arrive at a clinically meaningful diagnosis. Nevertheless, new and novel observations made under the microscope have improved our understanding of several existing conditions and paved the way toward recognition of newer entities. This review looks at a selection of inflammatory dermatoses which are either newly recognized or where unique microscopic findings published in recent years have refined our understanding of some established conditions.
{"title":"Emerging inflammatory dermatoses: New entities, novel observations, and concept review of selected established conditions","authors":"Kristofer Holte, A. Biswas","doi":"10.4103/ijdpdd.ijdpdd_63_18","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_63_18","url":null,"abstract":"There has been relatively little change during the past four decades in the way dermatopathologists approach and interpret biopsies obtained from inflammatory skin disorders. If anything, there has been a stronger emphasis on clinicopathologic correlation as an aid to arrive at a clinically meaningful diagnosis. Nevertheless, new and novel observations made under the microscope have improved our understanding of several existing conditions and paved the way toward recognition of newer entities. This review looks at a selection of inflammatory dermatoses which are either newly recognized or where unique microscopic findings published in recent years have refined our understanding of some established conditions.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122332367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.4103/ijdpdd.ijdpdd_42_18
S. Attili
Dermal melanophages are ubiquitous, present in a number of inflammatory and noninflammatory dermatoses. Dermal pigment incontinence is a result of effete keratinocytes or pigment-laden melanocytes (either naturally senescent or destroyed as a result of inflammation), dropping down into the papillary dermis. Subsequent mopping up of the melanin by dermal macrophages result in melanophages. The identification of the occasional melanophage in the dermis is nondiagnostic, as they represent mopping up of incidental senescent epidermal keratinocytes or melanocytes. A number of inflammatory dermatoses (including psoriasiform and spongiotic) result in dermal melanophages, though this is not well documented. This paper is the first to have attempted to confirm and quantify the presence of melanophages in diseases traditionally not associated with clinical pigmentation[1] (such as psoriasis, etc.). It is however common knowledge that psoriasis in Indian skin is usually pigmented.!
{"title":"Dermal melanophages: Does quantitative assessment play a role in the diagnosis of inflammatory skin diseases?","authors":"S. Attili","doi":"10.4103/ijdpdd.ijdpdd_42_18","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_42_18","url":null,"abstract":"Dermal melanophages are ubiquitous, present in a number of inflammatory and noninflammatory dermatoses. Dermal pigment incontinence is a result of effete keratinocytes or pigment-laden melanocytes (either naturally senescent or destroyed as a result of inflammation), dropping down into the papillary dermis. Subsequent mopping up of the melanin by dermal macrophages result in melanophages. The identification of the occasional melanophage in the dermis is nondiagnostic, as they represent mopping up of incidental senescent epidermal keratinocytes or melanocytes. A number of inflammatory dermatoses (including psoriasiform and spongiotic) result in dermal melanophages, though this is not well documented. This paper is the first to have attempted to confirm and quantify the presence of melanophages in diseases traditionally not associated with clinical pigmentation[1] (such as psoriasis, etc.). It is however common knowledge that psoriasis in Indian skin is usually pigmented.!","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126656344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.4103/ijdpdd.ijdpdd_56_18
R. Dhurat
Trichoscopy is evolving as an indispensable aid to the dermatologist by providing valuable clues on dermatoscopy of the scalp and hair. Trichoscopy presents as a bridging tool between clinical and histological diagnosis. It is useful to distinguish congenital atrichia from other forms of childhood hair loss such as alopecia universalis. There are a set of women who present with chronic hair loss without any discernible reduction in hair density over the crown. Such early forms are often overlooked, and clinical evaluation may not be adequate to make the right diagnosis. Trichoscopy has been widely used as a diagnostic as well as a prognostic tool to measure anisotrichosis in cases of overt androgenetic alopecia and female pattern hair loss (FPHL) and to distinguish them from telogen effluvium. It can be used to distinguish FPHL from diffuse and subtotal alopecia areata (AA) as well as trichotillomania from AA which can have similar clinical presentations. Trichoscopy also helps in monitoring treatment response in patients of AA. It is also useful in diagnosing infectious conditions such as noninflammatory tinea capitis, seborrheic dermatitis, piedra, and pediculosis. Trichoscopy represents a valuable, noninvasive and low-cost technique, still underutilized, to rapidly differentiate clinically frequent hair disorders.
{"title":"Utility of trichoscopy","authors":"R. Dhurat","doi":"10.4103/ijdpdd.ijdpdd_56_18","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_56_18","url":null,"abstract":"Trichoscopy is evolving as an indispensable aid to the dermatologist by providing valuable clues on dermatoscopy of the scalp and hair. Trichoscopy presents as a bridging tool between clinical and histological diagnosis. It is useful to distinguish congenital atrichia from other forms of childhood hair loss such as alopecia universalis. There are a set of women who present with chronic hair loss without any discernible reduction in hair density over the crown. Such early forms are often overlooked, and clinical evaluation may not be adequate to make the right diagnosis. Trichoscopy has been widely used as a diagnostic as well as a prognostic tool to measure anisotrichosis in cases of overt androgenetic alopecia and female pattern hair loss (FPHL) and to distinguish them from telogen effluvium. It can be used to distinguish FPHL from diffuse and subtotal alopecia areata (AA) as well as trichotillomania from AA which can have similar clinical presentations. Trichoscopy also helps in monitoring treatment response in patients of AA. It is also useful in diagnosing infectious conditions such as noninflammatory tinea capitis, seborrheic dermatitis, piedra, and pediculosis. Trichoscopy represents a valuable, noninvasive and low-cost technique, still underutilized, to rapidly differentiate clinically frequent hair disorders.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126890798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.4103/ijdpdd.ijdpdd_41_18
Astuty Apurwa, C. Desai, Shweta Agarwal, S. Patil
Spiny keratoderma is a rare disease; first described by Brown as “punctuate keratoderma”. It is characterized by asymptomatic keratotic pin point papules over palms and soles, resembling the old fashioned music box spine. The spiny spicules are often misdiagnosed and has a very subtle histopathological difference from punctate porokeratosis. With only less than 40 cases reported worldwide, we report our case as the very few mentioned in Indian literature.
{"title":"Spiny keratoderma: The gritty tale","authors":"Astuty Apurwa, C. Desai, Shweta Agarwal, S. Patil","doi":"10.4103/ijdpdd.ijdpdd_41_18","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_41_18","url":null,"abstract":"Spiny keratoderma is a rare disease; first described by Brown as “punctuate keratoderma”. It is characterized by asymptomatic keratotic pin point papules over palms and soles, resembling the old fashioned music box spine. The spiny spicules are often misdiagnosed and has a very subtle histopathological difference from punctate porokeratosis. With only less than 40 cases reported worldwide, we report our case as the very few mentioned in Indian literature.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"75 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116348511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.4103/ijdpdd.ijdpdd_28_18
R. Tirumalae, Inchara K. Yeliur, R. Ramesh, S. Manjunath
The term “collision tumor” implies the occurrence of two or more neoplasms in a single biopsy specimen. This is a rare feature in skin biopsies, with most of the reported combinations involving melanocytic lesions or basal cell carcinomas. Combinations of adnexal tumors are found very sporadically. We report a 67-year-old woman with a scalp nodule, clinically suspected to be verrucous carcinoma, who underwent a wide excision. Histopathology showed apocrine poroma with adjacent regressing pilomatricoma.
{"title":"Pilomatricoma with apocrine poroma: A novel cutaneous collision tumor","authors":"R. Tirumalae, Inchara K. Yeliur, R. Ramesh, S. Manjunath","doi":"10.4103/ijdpdd.ijdpdd_28_18","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_28_18","url":null,"abstract":"The term “collision tumor” implies the occurrence of two or more neoplasms in a single biopsy specimen. This is a rare feature in skin biopsies, with most of the reported combinations involving melanocytic lesions or basal cell carcinomas. Combinations of adnexal tumors are found very sporadically. We report a 67-year-old woman with a scalp nodule, clinically suspected to be verrucous carcinoma, who underwent a wide excision. Histopathology showed apocrine poroma with adjacent regressing pilomatricoma.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121448092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.4103/ijdpdd.ijdpdd_32_17
Rubal Jain, Sandeep S. Ojha, Abhishek Sharma
Syringocystadenoma papilliferum (SCAP) is a rare skin adnexal neoplasm of apocrine gland. One-third of SCAP cases are associated with nevus of Jadassohn. Its transition to squamous cell carcinoma is a rare entity. A strong clinical acumen, prompt excision, and confirmation by histopathology underline treatment of this cutaneous tumor. We report a case of this rare association in the deltoid region of a 55-year-old female.
{"title":"Syringocystadenoma papilliferum associated with naves sebaceous of jadassohn and squamous cell carcinoma","authors":"Rubal Jain, Sandeep S. Ojha, Abhishek Sharma","doi":"10.4103/ijdpdd.ijdpdd_32_17","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_32_17","url":null,"abstract":"Syringocystadenoma papilliferum (SCAP) is a rare skin adnexal neoplasm of apocrine gland. One-third of SCAP cases are associated with nevus of Jadassohn. Its transition to squamous cell carcinoma is a rare entity. A strong clinical acumen, prompt excision, and confirmation by histopathology underline treatment of this cutaneous tumor. We report a case of this rare association in the deltoid region of a 55-year-old female.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"443 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133723035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.4103/ijdpdd.ijdpdd_38_18
V. Gopalakrishnan, Jayasree Chandrasekharan, A. Prakash, Panachakunnel Samuel Mathew, B. Krishnanand
Sir, Wells syndrome (WS) is a rare inflammatory dermatoses first described by Wells in 1971.[1] It is characterized by acute, recurrent, and inflammatory urticarial and cellulitis-like indurated plaques with diffuse tissue eosinophilia, marked edema, and fibrinoid “flame figures.” [2] Eosinophilic panniculitis (EP) is a rare type of panniculitis with prominent eosinophilic infiltration of subcutaneous fat.[3] Both are rare entities by themselves; their association is even rarer.
{"title":"Eosinophilic panniculitis in wells syndrome: A unique association","authors":"V. Gopalakrishnan, Jayasree Chandrasekharan, A. Prakash, Panachakunnel Samuel Mathew, B. Krishnanand","doi":"10.4103/ijdpdd.ijdpdd_38_18","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_38_18","url":null,"abstract":"Sir, Wells syndrome (WS) is a rare inflammatory dermatoses first described by Wells in 1971.[1] It is characterized by acute, recurrent, and inflammatory urticarial and cellulitis-like indurated plaques with diffuse tissue eosinophilia, marked edema, and fibrinoid “flame figures.” [2] Eosinophilic panniculitis (EP) is a rare type of panniculitis with prominent eosinophilic infiltration of subcutaneous fat.[3] Both are rare entities by themselves; their association is even rarer.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133634132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.4103/ijdpdd.ijdpdd_21_17
Devleena Dev Barman, Palas Bhattacharyya, P. Ray, S. Sarkar, R. Sarkar, A. Roy
Aims and Objectives: Papulosquamous lesions, the largest conglomerate of skin diseases, are characterized by scaling papules and plaques which amount to lots of confusion, and hence, a definitive histopathological diagnosis has a significant role. Our study was thus aimed at evaluation of correlation between clinical diagnosis with histopathological diagnosis of different noninfectious erythematous papulosquamous skin lesions encountered in a tertiary care center. Materials and Methods: A total of 50 cases of noninfectious erythematous, papulosquamous lesions prediagnosed by dermatologists of the same institute were included over a period of 1 year. Diagnosis was confirmed by histopathological examination using hematoxylin and eosin stain. Cases were tabulated according to the distribution of age, gender, localization of lesions, clinical, and histopathological diagnosis. Results: Majority of the patients were in the 20–40 years age group (66%) with slight female preponderance (52%). The limbs (42%) were most frequently involved site. Histopathologically, lichen planus was the most common (52%) followed by psoriatic lesions (20%), pityriasis rosea (4%), pityriasis rubra pilaris (4%), subacute cutaneous lupus erythmatosus (4%), prurigo simplex (4%), pityriasis lichenoides chronica (4%), urticaria (2%) and ashy dermatosis (2%). Correlation of clinical with histopathological diagnosis was positive in 92% cases and negative in 8% cases. Conclusion: The contribution of histopathology to the final diagnosis was significant. Skin biopsy is thus valuable in daily dermatology practice and appropriate clinicopathological correlation is very important for the effective diagnosis and treatment of patients.
{"title":"Clinicopathological correlation of noninfectious erythematous papulosquamous cutaneous lesions in a tertiary care hospital","authors":"Devleena Dev Barman, Palas Bhattacharyya, P. Ray, S. Sarkar, R. Sarkar, A. Roy","doi":"10.4103/ijdpdd.ijdpdd_21_17","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_21_17","url":null,"abstract":"Aims and Objectives: Papulosquamous lesions, the largest conglomerate of skin diseases, are characterized by scaling papules and plaques which amount to lots of confusion, and hence, a definitive histopathological diagnosis has a significant role. Our study was thus aimed at evaluation of correlation between clinical diagnosis with histopathological diagnosis of different noninfectious erythematous papulosquamous skin lesions encountered in a tertiary care center. Materials and Methods: A total of 50 cases of noninfectious erythematous, papulosquamous lesions prediagnosed by dermatologists of the same institute were included over a period of 1 year. Diagnosis was confirmed by histopathological examination using hematoxylin and eosin stain. Cases were tabulated according to the distribution of age, gender, localization of lesions, clinical, and histopathological diagnosis. Results: Majority of the patients were in the 20–40 years age group (66%) with slight female preponderance (52%). The limbs (42%) were most frequently involved site. Histopathologically, lichen planus was the most common (52%) followed by psoriatic lesions (20%), pityriasis rosea (4%), pityriasis rubra pilaris (4%), subacute cutaneous lupus erythmatosus (4%), prurigo simplex (4%), pityriasis lichenoides chronica (4%), urticaria (2%) and ashy dermatosis (2%). Correlation of clinical with histopathological diagnosis was positive in 92% cases and negative in 8% cases. Conclusion: The contribution of histopathology to the final diagnosis was significant. Skin biopsy is thus valuable in daily dermatology practice and appropriate clinicopathological correlation is very important for the effective diagnosis and treatment of patients.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121107597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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