首页 > 最新文献

Indian Journal of Dermatopathology and Diagnostic Dermatology最新文献

英文 中文
Dermoscopic evaluation of crusted scabies: A case report 皮肤镜评价结痂性疥疮1例
Pub Date : 2021-01-01 DOI: 10.4103/ijdpdd.ijdpdd_42_20
B. Ankad, V. Koti, Sahebpatel Mahajabeen, Balakrishna P. Nikam
{"title":"Dermoscopic evaluation of crusted scabies: A case report","authors":"B. Ankad, V. Koti, Sahebpatel Mahajabeen, Balakrishna P. Nikam","doi":"10.4103/ijdpdd.ijdpdd_42_20","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_42_20","url":null,"abstract":"","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124456509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leukemia cutis presenting as non-healing ulcers with marginal umbilicated nodules 皮肤白血病表现为未愈合溃疡伴边缘脐状结节
Pub Date : 2021-01-01 DOI: 10.4103/ijdpdd.ijdpdd_108_20
Arunima Ray, I. Agrawal, R. Patnayak, B. Kar
{"title":"Leukemia cutis presenting as non-healing ulcers with marginal umbilicated nodules","authors":"Arunima Ray, I. Agrawal, R. Patnayak, B. Kar","doi":"10.4103/ijdpdd.ijdpdd_108_20","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_108_20","url":null,"abstract":"","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131564570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pseudoepitheliomatous keratotic and micaceous balanitis: A distinct entity 假性上皮瘤性角化和云母性龟头炎:一个独特的实体
Pub Date : 2021-01-01 DOI: 10.4103/ijdpdd.ijdpdd_93_20
A. Salloum, Julien Bachour, Nagham Bazzi, H. Mégarbané
Pseudoepitheliomatous keratotic and micaceous balanitis (PKMB), an uncommon glans penis skin disorder, affects mainly elderly men and can progress to verrucous carcinoma or invasive squamous cell carcinoma. A 22-year-old male presented with a 5-year history of a slightly pruritic thick scaly plaque on the glans penis that appeared 2 months after undergoing circumcision. Physical examination revealed a well-defined hyperkeratotic plaque with thin mica-like scales. Histological examination of previous biopsies showed acanthosis with elongation of the rete ridges, prominent granular cell layer, and marked orthokeratotic hyperkeratosis. The diagnosis of plaque-stage PKMB was made. The patient had monthly sessions of topical liquid nitrogen and after 20 weeks, the plaque shrank significantly.
假性上皮瘤性角化云母性龟头炎(PKMB)是一种罕见的龟头皮肤疾病,主要影响老年男性,可发展为疣状癌或侵袭性鳞状细胞癌。一例22岁男性患者,在行包皮环切术2个月后,出现阴茎龟头有轻微瘙痒的厚鳞状斑块,5年病史。体格检查发现一个清晰的角化过度斑块,有薄云母样鳞片。先前活检的组织学检查显示棘皮增生,网状嵴伸长,颗粒细胞层突出,明显的角化过度。诊断为斑块期PKMB。患者每月进行局部液氮治疗,20周后,斑块明显缩小。
{"title":"Pseudoepitheliomatous keratotic and micaceous balanitis: A distinct entity","authors":"A. Salloum, Julien Bachour, Nagham Bazzi, H. Mégarbané","doi":"10.4103/ijdpdd.ijdpdd_93_20","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_93_20","url":null,"abstract":"Pseudoepitheliomatous keratotic and micaceous balanitis (PKMB), an uncommon glans penis skin disorder, affects mainly elderly men and can progress to verrucous carcinoma or invasive squamous cell carcinoma. A 22-year-old male presented with a 5-year history of a slightly pruritic thick scaly plaque on the glans penis that appeared 2 months after undergoing circumcision. Physical examination revealed a well-defined hyperkeratotic plaque with thin mica-like scales. Histological examination of previous biopsies showed acanthosis with elongation of the rete ridges, prominent granular cell layer, and marked orthokeratotic hyperkeratosis. The diagnosis of plaque-stage PKMB was made. The patient had monthly sessions of topical liquid nitrogen and after 20 weeks, the plaque shrank significantly.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127167124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glomus tumor of uncertain malignant potential in the arm of an elderly female – Report of an unusual case 一位老年女性手臂上不确定恶性潜能的血管球瘤-罕见病例报告
Pub Date : 2020-07-01 DOI: 10.4103/ijdpdd.ijdpdd_53_20
Monal Trisal, Sabina Khan, M. Husain, M. Hassan, N. Ahmad, S. Jetley
Malignant glomus tumors (GTs) are very rare, and diagnosis requires consideration of specific histologic criteria based on a combination of criteria such as size of the tumor, degree of nuclear atypia, and the level of mitotic activity. GTs that do not fulfill the histologic criteria for malignancy but show at least one feature other than nuclear atypia should be classified as GT of uncertain malignant potential (GTUMP). We report the case of a 65-year-old female with a slowly progressing soft-tissue swelling in the right lower arm near the elbow joint that was successfully treated through wide surgical excision and histologically diagnosed as a GTUMP. On follow-up after 3 months, there was no evidence of recurrence or metastasis. Malignant GTs and GTUMPs are rare, and the nomenclature and classification of these tumors is controversial. These findings and the difficulty of differential diagnosis in a continuum between benignity and malignancy prompted our report.
恶性血管球瘤(GTs)非常罕见,诊断需要考虑基于肿瘤大小、核非典型性程度和有丝分裂活性水平等综合标准的特定组织学标准。不符合恶性肿瘤的组织学标准,但表现出除核非典型性以外至少一个特征的GT应归类为恶性潜能不确定GT (gump)。我们报告一例65岁女性右下臂肘关节附近缓慢进展的软组织肿胀,通过广泛手术切除成功治疗,组织学诊断为gump。3个月后随访,无复发或转移迹象。恶性GTs和GTUMPs是罕见的,这些肿瘤的命名和分类是有争议的。这些发现和鉴别诊断的困难在良性和恶性之间的连续性促使我们的报告。
{"title":"Glomus tumor of uncertain malignant potential in the arm of an elderly female – Report of an unusual case","authors":"Monal Trisal, Sabina Khan, M. Husain, M. Hassan, N. Ahmad, S. Jetley","doi":"10.4103/ijdpdd.ijdpdd_53_20","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_53_20","url":null,"abstract":"Malignant glomus tumors (GTs) are very rare, and diagnosis requires consideration of specific histologic criteria based on a combination of criteria such as size of the tumor, degree of nuclear atypia, and the level of mitotic activity. GTs that do not fulfill the histologic criteria for malignancy but show at least one feature other than nuclear atypia should be classified as GT of uncertain malignant potential (GTUMP). We report the case of a 65-year-old female with a slowly progressing soft-tissue swelling in the right lower arm near the elbow joint that was successfully treated through wide surgical excision and histologically diagnosed as a GTUMP. On follow-up after 3 months, there was no evidence of recurrence or metastasis. Malignant GTs and GTUMPs are rare, and the nomenclature and classification of these tumors is controversial. These findings and the difficulty of differential diagnosis in a continuum between benignity and malignancy prompted our report.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130741545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Loss of expression of claudin-1 in psoriasis is associated with proliferative state of keratinocytes claudin-1在银屑病中的表达缺失与角质形成细胞的增殖状态有关
Pub Date : 2020-07-01 DOI: 10.4103/ijdpdd.ijdpdd_85_20
M. Madakshira, B. Radotra, U. Saikia
Background: Psoriasis is a chronic remitting and relapsing inflammatory disease, with a prevalence of 0.44%–2.5% and is characterized by T-cell-mediated rapid turnover of epithelial cells. Claudin-1 protein is an integral part of the keratinocyte tight junction and has a role in proliferation, differentiation, and cell adhesion. Aim: The aim of the study was to investigate the role of claudin-1 expression in relation to keratinocyte proliferation in psoriasis. Materials and Methods: Fifty cases of psoriasis were included in the study. Skin biopsies were subjected to claudin-1 and Ki67 immunohistochemistry. Claudin-1 expression in the basal and spinous layers was scored. Ki67 proliferation index was assessed. Seven cases of normal skin biopsies were also included as controls. Fisher's exact test was applied for statistical analysis. Results: The cases had a wide age range (14–78 years), with a mean of 46 years with a male preponderance (4:1). The basal cell layer showed a complete loss of expression for claudin-1 in 82% (n = 42). The spinous layer showed a decrescendo pattern of loss of claudin-1 expression in 96% (n = 48). The association of loss of expression of claudin-1 between the basal layer and spinous layer was statistically significant (P = 0.0229). The association of loss of expression of claudin-1 and high Ki67 proliferative index was also statistically significant (P < 0.00001). Conclusion: Our study showed consistent loss of expression of claudin-1 in the lower layers of the epidermis in psoriasis, which is also the site of intense proliferative activity. The cytokine soup released by the T-cells may be responsible for downregulation of claudin-1, which is one of the triggers for proliferation.
背景:银屑病是一种慢性缓解性和复发性炎症性疾病,患病率为0.44%-2.5%,以t细胞介导的上皮细胞快速更新为特征。Claudin-1蛋白是角质形成细胞紧密连接的一个组成部分,在增殖、分化和细胞粘附中起作用。目的:探讨claudin-1表达在银屑病中与角质细胞增殖的关系。材料与方法:选取50例银屑病患者作为研究对象。皮肤活检进行claudin-1和Ki67免疫组化。测定细胞基底层和棘层中Claudin-1的表达。测定Ki67增殖指数。7例正常皮肤活检作为对照。采用费雪精确检验进行统计分析。结果:本组病例年龄广泛(14 ~ 78岁),平均46岁,以男性为主(4:1)。82%的基底细胞层完全丧失claudin-1的表达(n = 42)。棘层显示96%的claudin-1表达减少(n = 48)。claudin-1表达缺失在基底层和棘层之间的相关性有统计学意义(P = 0.0229)。claudin-1表达缺失与Ki67高增殖指数的相关性也有统计学意义(P < 0.00001)。结论:我们的研究表明,在银屑病中,claudin-1在表皮下层的表达持续缺失,而这也是银屑病增殖活性强烈的部位。t细胞释放的细胞因子汤可能导致claudin-1的下调,claudin-1是细胞增殖的触发因素之一。
{"title":"Loss of expression of claudin-1 in psoriasis is associated with proliferative state of keratinocytes","authors":"M. Madakshira, B. Radotra, U. Saikia","doi":"10.4103/ijdpdd.ijdpdd_85_20","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_85_20","url":null,"abstract":"Background: Psoriasis is a chronic remitting and relapsing inflammatory disease, with a prevalence of 0.44%–2.5% and is characterized by T-cell-mediated rapid turnover of epithelial cells. Claudin-1 protein is an integral part of the keratinocyte tight junction and has a role in proliferation, differentiation, and cell adhesion. Aim: The aim of the study was to investigate the role of claudin-1 expression in relation to keratinocyte proliferation in psoriasis. Materials and Methods: Fifty cases of psoriasis were included in the study. Skin biopsies were subjected to claudin-1 and Ki67 immunohistochemistry. Claudin-1 expression in the basal and spinous layers was scored. Ki67 proliferation index was assessed. Seven cases of normal skin biopsies were also included as controls. Fisher's exact test was applied for statistical analysis. Results: The cases had a wide age range (14–78 years), with a mean of 46 years with a male preponderance (4:1). The basal cell layer showed a complete loss of expression for claudin-1 in 82% (n = 42). The spinous layer showed a decrescendo pattern of loss of claudin-1 expression in 96% (n = 48). The association of loss of expression of claudin-1 between the basal layer and spinous layer was statistically significant (P = 0.0229). The association of loss of expression of claudin-1 and high Ki67 proliferative index was also statistically significant (P < 0.00001). Conclusion: Our study showed consistent loss of expression of claudin-1 in the lower layers of the epidermis in psoriasis, which is also the site of intense proliferative activity. The cytokine soup released by the T-cells may be responsible for downregulation of claudin-1, which is one of the triggers for proliferation.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131621768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary cutaneous mucinous carcinoma: A rare case report 原发性皮肤黏液癌1例报告
Pub Date : 2020-07-01 DOI: 10.4103/ijdpdd.ijdpdd_9_20
K. Roopa, M. Jadhav, S. Kittur, G. Pise
Primary cutaneous mucinous carcinoma is a rare slowly growing neoplasm showing predilection for the head and neck, particularly the eyelids. On occasion, it affects other sites including scalp, face, ear, axillae, thorax, abdomen, groin, foot, hand, and vulva. Fewer than 150 cases have been reported in the literature. A 70-year-old man presented with an asymptomatic raised lesion over the left side of the face for 1 year. Microscopically, the diagnosis of primary cutaneous mucinous carcinoma was made, which was later confirmed by immunohistochemistry. Mucinous carcinoma of the skin has a relatively good prognosis with rare distant metastases, but has risk of local recurrence. Diagnosing it and differentiating it from metastatic carcinoma helps the clinician in further management of the patient.
原发性皮肤黏液癌是一种罕见的生长缓慢的肿瘤,多发生于头颈部,尤其是眼睑。有时,它会影响其他部位,包括头皮、面部、耳朵、腋窝、胸部、腹部、腹股沟、脚、手和外阴。文献报道的病例不足150例。一个70岁的男人提出了一个无症状的凸起病变在左侧脸1年。显微镜下诊断为原发性皮肤黏液癌,免疫组化证实。皮肤黏液性癌预后较好,很少有远处转移,但有局部复发的危险。诊断它并将其与转移性癌区分开来有助于临床医生进一步治疗患者。
{"title":"Primary cutaneous mucinous carcinoma: A rare case report","authors":"K. Roopa, M. Jadhav, S. Kittur, G. Pise","doi":"10.4103/ijdpdd.ijdpdd_9_20","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_9_20","url":null,"abstract":"Primary cutaneous mucinous carcinoma is a rare slowly growing neoplasm showing predilection for the head and neck, particularly the eyelids. On occasion, it affects other sites including scalp, face, ear, axillae, thorax, abdomen, groin, foot, hand, and vulva. Fewer than 150 cases have been reported in the literature. A 70-year-old man presented with an asymptomatic raised lesion over the left side of the face for 1 year. Microscopically, the diagnosis of primary cutaneous mucinous carcinoma was made, which was later confirmed by immunohistochemistry. Mucinous carcinoma of the skin has a relatively good prognosis with rare distant metastases, but has risk of local recurrence. Diagnosing it and differentiating it from metastatic carcinoma helps the clinician in further management of the patient.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125480763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histiocytic sarcoma: An encounter with a rarity 组织细胞肉瘤:罕见的遭遇
Pub Date : 2020-07-01 DOI: 10.4103/ijdpdd.ijdpdd_4_20
N. Kartha, K. Sobhanakumari, Predesh Jose
Histiocytic sarcoma is a rare hematolymphoid neoplasm originating from histiocytic cell clones. The lesions can occur in nodal or extranodal sites. A minority of cases present as unique cutaneous lesions. The definitive diagnosis is made by immunohistochemistry. The treatment depends on the severity of the disease. Herein, we report a case of histiocytic sarcoma in a 65-year-old female presenting with subcutaneous swellings and ulcerated coalescing nodules on the forearms and thighs with metastasis to the lung and treated with systemic chemotherapy.
组织细胞肉瘤是一种罕见的起源于组织细胞克隆的血淋巴肿瘤。病变可发生在淋巴结或结外部位。少数病例表现为独特的皮肤病变。最终诊断由免疫组织化学作出。治疗方法取决于疾病的严重程度。在此,我们报告一例65岁女性的组织细胞肉瘤,表现为前臂和大腿皮下肿胀和溃疡合并结节,并转移到肺部,并接受全身化疗。
{"title":"Histiocytic sarcoma: An encounter with a rarity","authors":"N. Kartha, K. Sobhanakumari, Predesh Jose","doi":"10.4103/ijdpdd.ijdpdd_4_20","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_4_20","url":null,"abstract":"Histiocytic sarcoma is a rare hematolymphoid neoplasm originating from histiocytic cell clones. The lesions can occur in nodal or extranodal sites. A minority of cases present as unique cutaneous lesions. The definitive diagnosis is made by immunohistochemistry. The treatment depends on the severity of the disease. Herein, we report a case of histiocytic sarcoma in a 65-year-old female presenting with subcutaneous swellings and ulcerated coalescing nodules on the forearms and thighs with metastasis to the lung and treated with systemic chemotherapy.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115572170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermoscopy of actinic keratosis in skin of color 有色皮肤光化性角化病的皮肤镜检查
Pub Date : 2020-07-01 DOI: 10.4103/ijdpdd.ijdpdd_98_20
Y. Bhat, Safia Bashir, Rohi Wani, N. Saqib
{"title":"Dermoscopy of actinic keratosis in skin of color","authors":"Y. Bhat, Safia Bashir, Rohi Wani, N. Saqib","doi":"10.4103/ijdpdd.ijdpdd_98_20","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_98_20","url":null,"abstract":"","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121119668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Subungual myxoid neurothekeoma of the toe: A rare entity 趾骨下粘液样神经瘤:一种罕见的疾病
Pub Date : 2020-07-01 DOI: 10.4103/ijdpdd.ijdpdd_17_20
B. Srinivasamurthy, R. Bhat
Myxoid neurothekeomas are rare benign soft-tissue tumors that are considered to be of the nerve sheath origin. They usually occur in young most commonly on the upper extremities, head, and neck, with a predilection for the female population. Based on histomorphological appearance and immunohistochemical findings, there are three variants of neurothekeoma myxoid, cellular, and mixed type. The myxoid type is characterized by a greater degree of myxomatous changes, less cellularity with well-circumscribed spindle cells in the myxoid matrix, and stain positively for S-100. This has to be differentiated from several myxoid soft-tissue tumors. We present a rare case of myxoid neurothekeoma occurring in elderly females in the toe of the lower extremity.
黏液样神经瘤是一种罕见的良性软组织肿瘤,被认为起源于神经鞘。它们通常发生在年轻人中,最常见于上肢、头部和颈部,以女性人群为主。根据组织形态学和免疫组化结果,神经瘤有三种变体:黏液型、细胞型和混合型。黏液型的特点是黏液样基质中黏液瘤变程度更大,胞质较少,梭形细胞界限分明,S-100染色阳性。必须与多种粘液样软组织肿瘤鉴别。我们报告一例发生在老年女性下肢脚趾的罕见粘液样神经瘤。
{"title":"Subungual myxoid neurothekeoma of the toe: A rare entity","authors":"B. Srinivasamurthy, R. Bhat","doi":"10.4103/ijdpdd.ijdpdd_17_20","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_17_20","url":null,"abstract":"Myxoid neurothekeomas are rare benign soft-tissue tumors that are considered to be of the nerve sheath origin. They usually occur in young most commonly on the upper extremities, head, and neck, with a predilection for the female population. Based on histomorphological appearance and immunohistochemical findings, there are three variants of neurothekeoma myxoid, cellular, and mixed type. The myxoid type is characterized by a greater degree of myxomatous changes, less cellularity with well-circumscribed spindle cells in the myxoid matrix, and stain positively for S-100. This has to be differentiated from several myxoid soft-tissue tumors. We present a rare case of myxoid neurothekeoma occurring in elderly females in the toe of the lower extremity.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132705579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leukemia cutis: A study from a tertiary care hospital in North India 皮肤白血病:一项来自印度北部三级医院的研究
Pub Date : 2020-07-01 DOI: 10.4103/ijdpdd.ijdpdd_33_20
M. Madakshira, A. Bishnoi, D. De, M. Sachdeva, U. Saikia
Background/Objectives: Only anecdotal case reports or small case series have attempted to study the histomorphology patterns of leukemic infiltration. This study explored the possible association of leukemia cutis with, temporal course of disease, subtypes of leukemia, blast count, total leukocyte count, lactate dehydrogenase (LDH) levels, and histopathological patterns. Materials and Methods: Clinical and laboratory data were retrieved from the hospital information system. Selected cases were reviewed by two pathologists. Data in terms of demographics, clinical presentation, bone marrow findings, immunophenotype, and temporal course were recorded where available. Results: Twenty-three diagnosed cases of leukemia cutis were reported during the study period. There was no gender predilection with a wide age range (8–82 years). No particular trend was noted in relation to total leukocyte or bone marrow blast count. Common skin manifestations included multiple erythematous papular eruptions, frequently involving the skin of the limbs. All cases showed a consistently high serum LDH level. 11/23 (48%) showed cutaneous manifestation of undiagnosed leukemia or indicated worsening in a diagnosed case. The histological patterns varied from perivascular to diffuse dermal interstitial infiltration. In addition, subtle changes were seen in the form of fibrosis, thrombosis, and epidermotropism in 12%–50% of cases. The judicious use of a panel of immunohistochemistry was vital to establish a diagnosis. Conclusions: Leukemia cutis is a diagnostic challenge on histopathology due to lack of any specific pattern in absence of a clinical suspicion. Its diagnosis may be an indicator of undiagnosed leukemia or worsening in an already known case of leukemia.
背景/目的:只有轶事病例报告或小病例系列试图研究白血病浸润的组织形态学模式。本研究探讨了皮肤白血病与时间病程、白血病亚型、原细胞计数、白细胞总数、乳酸脱氢酶(LDH)水平和组织病理学模式的可能关联。材料与方法:从医院信息系统中检索临床和实验室资料。所选病例由两名病理学家复查。人口统计学、临床表现、骨髓发现、免疫表型和时间病程方面的数据被记录下来。结果:研究期间共报告23例皮肤白血病确诊病例。无性别偏好,年龄范围广(8 ~ 82岁)。白细胞总数或骨髓母细胞计数没有特别的变化趋势。常见的皮肤表现包括多发红斑丘疹,常累及四肢皮肤。所有病例均表现出一贯的高血清LDH水平。11/23(48%)有未确诊白血病的皮肤表现或确诊病例有恶化迹象。组织学类型从血管周围浸润到弥漫性真皮间质浸润不等。此外,12%-50%的病例出现纤维化、血栓形成和表皮性改变。明智地使用免疫组织化学小组对确定诊断至关重要。结论:由于缺乏任何特定的模式,缺乏临床怀疑,皮肤白血病在组织病理学上是一个诊断挑战。它的诊断可能是未确诊的白血病的一个指标,或者在已知的白血病病例中恶化。
{"title":"Leukemia cutis: A study from a tertiary care hospital in North India","authors":"M. Madakshira, A. Bishnoi, D. De, M. Sachdeva, U. Saikia","doi":"10.4103/ijdpdd.ijdpdd_33_20","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_33_20","url":null,"abstract":"Background/Objectives: Only anecdotal case reports or small case series have attempted to study the histomorphology patterns of leukemic infiltration. This study explored the possible association of leukemia cutis with, temporal course of disease, subtypes of leukemia, blast count, total leukocyte count, lactate dehydrogenase (LDH) levels, and histopathological patterns. Materials and Methods: Clinical and laboratory data were retrieved from the hospital information system. Selected cases were reviewed by two pathologists. Data in terms of demographics, clinical presentation, bone marrow findings, immunophenotype, and temporal course were recorded where available. Results: Twenty-three diagnosed cases of leukemia cutis were reported during the study period. There was no gender predilection with a wide age range (8–82 years). No particular trend was noted in relation to total leukocyte or bone marrow blast count. Common skin manifestations included multiple erythematous papular eruptions, frequently involving the skin of the limbs. All cases showed a consistently high serum LDH level. 11/23 (48%) showed cutaneous manifestation of undiagnosed leukemia or indicated worsening in a diagnosed case. The histological patterns varied from perivascular to diffuse dermal interstitial infiltration. In addition, subtle changes were seen in the form of fibrosis, thrombosis, and epidermotropism in 12%–50% of cases. The judicious use of a panel of immunohistochemistry was vital to establish a diagnosis. Conclusions: Leukemia cutis is a diagnostic challenge on histopathology due to lack of any specific pattern in absence of a clinical suspicion. Its diagnosis may be an indicator of undiagnosed leukemia or worsening in an already known case of leukemia.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128625376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Indian Journal of Dermatopathology and Diagnostic Dermatology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1