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Dermoscopy of disseminated superficial actinic porokeratosis in skin of color 有色皮肤弥散性浅浅光化性角化症的皮肤镜检查
Pub Date : 2020-07-01 DOI: 10.4103/ijdpdd.ijdpdd_46_20
Y. Bhat, Nahida Nabi, Rohi Wani
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引用次数: 2
Cutaneous angiofibroma: A clinching evidence for diagnostic workup of tuberous sclerosis complex 皮肤血管纤维瘤:结节性硬化症复合体诊断的确凿证据
Pub Date : 2020-07-01 DOI: 10.4103/ijdpdd.ijdpdd_54_20
B. Warpe, Bhagyashree S. Mundhe, Shweta Joshi-Warpe, Ashwin Kulkarni
Tuberous sclerosis complex (TSC) or Bourneville's disease is a genetic multisystem disorder of multisite hamartomas. Majority of TSC cases are sporadic. TSC typically presents in the first decade of life and has a reported incidence of 1:6000–12,000, with intracranial involvement in the form of cortical tubers or subependymal nodules. Tubers (potato-like nodules) are triangular-shaped lesions centered at the cortex/juxtacortical, with apex oriented “inward” toward the ventricles, on magnetic resonance imaging (MRI) of the brain. Tubers represent cortical glioneuronal hamartomas and consist of focal distortions in the cellular organization and morphology, which extend into the underlying (subcortical) white matter. Skin lesions with a history of seizures can be an eye-opener to diagnose angiofibromas and its variant, which can lead to further effective workup such as ophthalmoscopy and MRI of the brain to diagnose TSC, just like in our case.
结节性硬化症(TSC)或伯纳维尔病是一种多位点错构瘤的遗传性多系统疾病。大多数TSC病例是散发的。TSC通常出现在生命的前10年,据报道发病率为1:6000-12,000,以皮质结节或室管膜下结节的形式累及颅内。脑核磁共振成像(MRI)显示,块茎(马铃薯样结节)为以皮层/近皮层为中心的三角形病变,尖端向内朝向脑室。结节代表皮层胶质神经元错构瘤,由细胞组织和形态的局灶性扭曲组成,并延伸至底层(皮层下)白质。有癫痫发作史的皮肤病变对血管纤维瘤及其变体的诊断是一个令人大开眼界的发现,这可以导致进一步有效的检查,如眼科检查和脑部MRI来诊断TSC,就像我们的病例一样。
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引用次数: 1
A rare case of Brooke–Spiegler syndrome 罕见的布鲁克-斯皮格勒综合症
Pub Date : 2020-07-01 DOI: 10.4103/ijdpdd.ijdpdd_18_20
Anuja Sunkwad, S. Mahajan, J. Dave, D. Das
Brooke–Spiegler syndrome (BSS) is a rare autosomal dominant inherited disorder characterized by multiple skin appendageal tumors. The predominant tumors can be a cylindroma, trichoepithelioma, and/or spiradenoma. Here we report this rare entity of Brooke–Spiegler syndrome in a 50 year old female on the basis of clinico-histopathological correlation. The gene responsible for this condition is cylindromatosis gene (CYLD1) which has been mapped on chromosome 16q12–q13. However, no mutation have been detected in CYLD gene analyzed in our patient which indicates lack of genotype–phenotype correlation in this patient.
布鲁克-斯皮格勒综合征(BSS)是一种罕见的常染色体显性遗传疾病,其特征是多发性皮肤附属物肿瘤。主要肿瘤可为柱状瘤、毛上皮瘤和/或螺旋腺瘤。在此,我们报告一例罕见的布鲁克-斯皮格勒综合征,患者为50岁女性,基于临床-组织病理学相关性。导致这种情况的基因是圆柱形病基因(CYLD1),已被定位在染色体16q12-q13上。然而,在我们的患者中,没有检测到CYLD基因突变,这表明该患者缺乏基因型-表型相关性。
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引用次数: 0
Zosteriform lymphangioma circumscriptum and angiokeratoma: A rare co-occurrence 带状疱疹状淋巴管瘤边缘和血管角质瘤:罕见的同时发生
Pub Date : 2020-07-01 DOI: 10.4103/ijdpdd.ijdpdd_96_20
P. Kowe, S. Malpani, V. Wankhade, R. Singh
Lymphangioma circumscriptum (LC) is a rare benign hamartomatous malformation of lymph vessel manifesting at birth or during early childhood. Angiokeratomas (AK) are vascular ectasia of papillary dermal blood vessels with secondary epidermal changes. AK and/or LC are one of the common vascular malformations associated with Klippel–Trenaunay syndrome (KTS). The simultaneous appearance of LC and AK has been reported rarely, and the occurrence of LC, AK, and port-wine stain in a patient of KTS is even rarer. Thereby, we report a case of co-occurrence of LC and AK in the same patient without systemic involvement.
摘要周边淋巴管瘤(LC)是一种罕见的良性错构瘤性淋巴管畸形,表现于出生时或儿童早期。血管角化瘤(AK)是真皮乳头状血管扩张伴继发性表皮改变。AK和/或LC是Klippel-Trenaunay综合征(KTS)常见的血管畸形之一。LC和AK同时出现的报道很少,在KTS患者中LC, AK和波特酒染色的出现更是罕见。因此,我们报告一例LC和AK同时发生在同一患者没有全身累及。
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引用次数: 0
Study of seborrheic keratosis by dermoscopy using polarized and nonpolarized modes 极化和非极化模式下皮肤镜对脂溢性角化病的研究
Pub Date : 2020-07-01 DOI: 10.4103/ijdpdd.ijdpdd_48_20
Bhavesh Sonagara, Hita H. Mehta, B. Astik, N. Agrawal
Background: Seborrheic keratosis (SK) is the most common benign skin tumor. Dermatoscope is a simple noninvasive diagnostic tool. Although SK has been well recognized clinically, dermoscopically, and histopathologically, data regarding dermoscopic differentiation of different types of SK using the polarized (P) and nonpolarized (NP) modes of dermoscopy are inadequate. Objectives: The objective was to study the dermoscopic pattern of different types of SK under P and NP dermoscopic modes. Methodology: A descriptive study of 102 patients was carried out after ethical approval. All patients attending the dermatology outpatient department with lesions who were willing to participate in the study were included in the study after taking written informed consent. After a detailed history and examination, clinical and dermoscopic photographs were taken under the P and NP modes of a dermoscope attached with a smartphone camera. Biopsy of the same lesions was sent for a histopathology examination. Results: A total of 102 patients were studied. Females (58) outnumbered males (44). The most common clinical variant was common SK. The most common histopathological type of SK was hyperkeratotic followed by acanthotic type. Sharp demarcated border (75%) was the most common finding on dermoscopy in our study followed by fissure and ridges (63%), scales (54%), comedo-like opening (34%), cobblestone-like pattern (33%), moth-eaten border (17.7%), and cerebriform pattern (13.7%). Conclusion: NP mode helps in better visualization as well as depth perception, whereas P mode shows better color perception and sharpness of superficial as well as deep dermoscopic structures.
背景:脂溢性角化病(SK)是最常见的良性皮肤肿瘤。皮镜是一种简单的无创诊断工具。虽然SK在临床上、皮肤镜下和组织病理学上都得到了很好的认可,但使用皮肤镜极化(P)和非极化(NP)模式对不同类型SK的皮肤镜分化的数据是不充分的。目的:研究不同类型SK在P、NP两种皮肤镜模式下的皮肤镜形态。方法:经伦理批准,对102例患者进行描述性研究。所有在皮肤科门诊就诊且有病变且愿意参与研究的患者均在填写书面知情同意书后纳入研究。在详细的病史和检查后,在附有智能手机摄像头的皮肤镜的P和NP模式下拍摄临床和皮肤镜照片。同一病变的活检被送去做组织病理学检查。结果:共纳入102例患者。女性(58人)多于男性(44人)。最常见的临床变异是普通SK,最常见的组织病理学类型是角化过度,其次是棘层型。在我们的研究中,皮肤镜检查最常见的发现是尖锐的边界(75%),其次是裂缝和脊(63%),鳞片(54%),粉刺样开放(34%),卵石样模式(33%),虫蛀边界(17.7%)和脑状模式(13.7%)。结论:NP模式有助于更好的视觉和深度感知,而P模式对浅层和深层皮肤结构具有更好的颜色感知和清晰度。
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引用次数: 0
Curious case of coexistence of erythema induratum and penile papulonecrotic tuberculid 硬疹与阴茎丘疹性坏死结核共存的奇怪病例
Pub Date : 2020-01-01 DOI: 10.4103/ijdpdd.ijdpdd_36_20
Molisha Bhandari, G. Khullar, Shruti Sharma, V. Ramesh
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引用次数: 0
Benign fibrohistiocytic tumour of the palate 上颚良性纤维组织细胞瘤
Pub Date : 2020-01-01 DOI: 10.4103/ijdpdd.ijdpdd_12_19
Nilima Sharma, M. Hassan
Benign fibrous histiocytomas of soft tissue are composed of spindled fibroblasts admixed with secondary elements including histiocytes, foam cells, and inflammatory cells. These tumors occur equally in males and females and most often arise in the dermis and subcutaneous tissues. We report a rare case of benign fibrous histiocytic tumor of the palate with histologic features and immunohistochemical characteristics.
软组织的良性纤维组织细胞瘤是由纺锤状成纤维细胞混合次级成分,包括组织细胞、泡沫细胞和炎症细胞组成。这些肿瘤在男性和女性中同样发生,最常发生在真皮和皮下组织。我们报告一例罕见的上颚良性纤维组织细胞瘤,其组织学特征和免疫组织化学特征。
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引用次数: 2
Evaluation of active and stable stages of vitiligo using S-100 and human melanoma black-45 immunostains 用S-100和黑-45免疫染色评价白癜风活动期和稳定期
Pub Date : 2020-01-01 DOI: 10.4103/ijdpdd.ijdpdd_44_19
Gurpinder Kaur, R. Punia, R. Kundu, G. Thami
Background: Vitiligo is the most prevalent pigmentary disorder occurring worldwide. In most cases, the diagnosis is made by clinical examination alone. The disease status (active/stable) needs to be assessed to make appropriate therapeutic decisions. Objective: The aim of the present study was to evaluate the histopathological and immunohistochemical features in active and stable lesions. Materials and Methods: Biopsies from vitiliginous areas from 50 patients (25 each of clinically active and stable vitiligo); with hematoxylin and eosin, Masson Fontana (MF), S-100, and human melanoma black-45 (HMB-45) stained sections were studied. Results: Age of the patients ranged from 7 to 69 years (mean age: 33.6 ± 15.73 years). Of 50 patients, 27 (54%) were male and 23 (46%) were female. All the cases showed variable degree of basal hypopigmentation. Histopathological findings, epidermal spongiosis, basal vacuolar degeneration, dermal melanophages, and dermal lymphomononuclear cells were commonly observed in active lesions as compared to the stable ones. On MF staining, 23/25 cases (92%) of active vitiligo showed complete loss of basal melanin. Quantitative analysis of HMB-45 immunostaining in stable and active vitiligo revealed mean number of positive melanocytes as 2.52 ± 1.0/high power field (hpf) and 0.08 ± 0.28/hpf, respectively, while on S-100 immunostaining the mean values of positive Langerhans cells were 1.70 ± 0.38/hpf and 7.78 ± 4.11/hpf, respectively. Conclusion: The demonstration of overall reduction in the number of HMB-45-positive melanocytes and increase in S-100-positive Langerhans dendritic cells in the active vitiligo lesions is facilitated by immunohistochemistry. The technique is of immense help in differentiating active and stable stages of vitiligo, thus guiding therapy.
背景:白癜风是世界范围内最常见的色素疾病。在大多数情况下,诊断仅由临床检查作出。需要评估疾病状态(活跃/稳定)以做出适当的治疗决定。目的:本研究的目的是评价活动性和稳定性病变的组织病理学和免疫组织化学特征。材料与方法:50例白癜风患者(临床活动性和稳定性各25例)白癜风区活检;苏木精和伊红染色,Masson Fontana (MF), S-100和human melanoma black-45 (HMB-45)染色切片。结果:患者年龄7 ~ 69岁,平均年龄33.6±15.73岁。50例患者中,男性27例(54%),女性23例(46%)。所有病例均表现不同程度的基底色素沉着。与稳定病变相比,活动性病变常见于表皮海绵状病变、基底空泡变性、真皮噬黑素细胞和真皮淋巴单核细胞。MF染色显示,23/25例(92%)活动性白癜风患者基底黑色素完全丧失。HMB-45免疫染色在稳定型和活动力型白癜风中显示黑色素细胞阳性的平均值分别为2.52±1.0/ hpf和0.08±0.28/hpf,而S-100免疫染色显示Langerhans细胞阳性的平均值分别为1.70±0.38/hpf和7.78±4.11/hpf。结论:免疫组化显示活动性白癜风病变中hmb -45阳性黑色素细胞数量总体减少,s -100阳性朗格汉斯树突状细胞数量总体增加。该技术在区分白癜风的活跃和稳定阶段具有巨大的帮助,从而指导治疗。
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引用次数: 2
Cystic follicular hamartoma: A rare case report 囊性滤泡错构瘤1例
Pub Date : 2020-01-01 DOI: 10.4103/ijdpdd.ijdpdd_44_20
C. Desai, Saurabh Shah
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引用次数: 0
A possible role of WNT5A expression in papulosquamous skin diseases WNT5A表达在丘疹鳞状皮肤病中的可能作用
Pub Date : 2020-01-01 DOI: 10.4103/ijdpdd.ijdpdd_59_19
L. Mohamed, E. Hasby, H. Kassem, Nashwa N Elfar
Background: Wnt genes code for a family of secreted, lipid-modified glycoproteins. Wnt5a has important functions in cell proliferation, fate determination, and differentiation. Dysregulation of Wnt5a signaling implicated in multiple disease. Aim of Work: The aim is to elucidate the possible role of Wnt5a in pathogenesis of papulosquamous skin disorders through the evaluation of its expression immunohistochemically. Patients and Methods: This study included 80 patients with various papulosquamous diseases (psoriasis, lichen planus, ptyriasis rosea, and ptyriasis rubra pilaris), in addition to 20 healthy controls served as control. Punch skin biopsies were taken from all individuals for immunohistochemical staining with Wnt5a. Results: There was a highly statistically significant upregulation in Wnt5a expression in all stained skin specimens of the studied papulosquamous diseases in both epidermis and dermal lymphocytes compared to normal control. Conclusion: The upregulated expression of Wnt5a indicated its involvement in pathogenesis of papulosquamous diseases. Wnt5a and/or its receptor can be a challenging target for therapeutic intervention. Regular follow-up for these patients is recommended as Wnt5a also may be involved in their malignant transformation.
背景:Wnt基因编码一个分泌的、脂质修饰的糖蛋白家族。Wnt5a在细胞增殖、命运决定和分化中具有重要功能。Wnt5a信号失调与多种疾病有关。工作目的:目的是通过免疫组织化学评价Wnt5a在丘疹鳞状皮肤病发病机制中的表达,阐明其可能的作用。患者和方法:本研究纳入80例各种丘疹鳞状疾病(银屑病、扁平苔藓、玫瑰乳头状炎和毛毛红色乳头状炎)患者,并以20例健康对照为对照。对所有个体进行皮肤活检,用Wnt5a进行免疫组化染色。结果:在所研究的丘疹鳞状病变的所有染色皮肤标本中,与正常对照相比,表皮和真皮淋巴细胞中Wnt5a的表达均有高度统计学意义的上调。结论:Wnt5a表达上调提示其参与了丘疹鳞状病变的发病机制。Wnt5a和/或其受体可能是治疗干预的一个具有挑战性的靶点。建议对这些患者进行定期随访,因为Wnt5a也可能参与其恶性转化。
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引用次数: 1
期刊
Indian Journal of Dermatopathology and Diagnostic Dermatology
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