Pub Date : 2022-06-17DOI: 10.25276/0235-4160-2022-2-67-76
A. Sidorova, A. V. Starostina, K. A. Stefankova, E.S. Mustafaeva, M.S. Jereshtieva, A. Aydinyan
Purpose. To analyze the literature reflecting the main modern methods of visualizing the angle of the anterior chamber of the eye, which are used in patients with glaucoma. Material and methods. To perform the review, a search was carried out for literature sources on the Pubmed, Scopus and Elibrary reference databases for the period up to 2022 inclusive using the following keywords: anterior camera angle, gonioscopy, electronic gonioscopy, optical coherence tomography, ultrasound biomicroscopy and the same phrases in Russian. Results. The variety of clinical and morphological forms of glaucoma, the wide prevalence, frequency of occurrence and steady growth of this disease require timely diagnostics, as well as dynamic monitoring of the results of conservative and surgical treatment in patients with glaucoma. Despite the importance of such a diagnostic method as gonioscopy, ophtalmologists still do not use it sufficiently, the frequency of its application during the first visit to the doctor for glaucoma varies from 17.96 to 45.9%. There are also additional instrumental methods of examination of patients with glaucoma that allow an objective assessment of the structures of the eye anterior segment: automated gonioscopy, optical coherence tomography of the eye anterior segment and ultrasound biomicroscopy. These methods can be used both for the primary diagnosis of glaucoma and its dynamic observation, as well as for choosing surgical treatment tactics and monitoring its results thanks to high-precision visualisation and image documentation. Each of them has its own characteristics, advantages and disadvantages, depending on the specifics of the disease and the presence of concomitant ocular pathology, which are described in this article. Conclusion. Taking into account the variety of clinical forms of glaucoma and the insufficient equipment of medical institutions, especially primary care, it can be concluded that it is necessary to improve diagnostic algorithms. Methods such as electronic gonioscopy, optical coherence tomography of the eye anterior segment and ultrasound biomicroscopy will make the diagnostic process more accurate and informative, help to correctly diagnose and determine treatment tactics for both primary care physicians and surgeons. The possibility of documenting the results obtained and creating a system for their analysis can contribute to the founding of a generalized database, which will greatly simplify and accelerate the process of providing care to patients with glaucoma. Key words: glaucoma, anterior chamber angle, gonioscopy, electronic gonioscopy, optical coherence tomography, ultrasound biomicroscopy
{"title":"Modern methods of visualization of the angle of the anterior chamber of the eye in the diagnosis and treatment of glaucoma","authors":"A. Sidorova, A. V. Starostina, K. A. Stefankova, E.S. Mustafaeva, M.S. Jereshtieva, A. Aydinyan","doi":"10.25276/0235-4160-2022-2-67-76","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-2-67-76","url":null,"abstract":"Purpose. To analyze the literature reflecting the main modern methods of visualizing the angle of the anterior chamber of the eye, which are used in patients with glaucoma. Material and methods. To perform the review, a search was carried out for literature sources on the Pubmed, Scopus and Elibrary reference databases for the period up to 2022 inclusive using the following keywords: anterior camera angle, gonioscopy, electronic gonioscopy, optical coherence tomography, ultrasound biomicroscopy and the same phrases in Russian. Results. The variety of clinical and morphological forms of glaucoma, the wide prevalence, frequency of occurrence and steady growth of this disease require timely diagnostics, as well as dynamic monitoring of the results of conservative and surgical treatment in patients with glaucoma. Despite the importance of such a diagnostic method as gonioscopy, ophtalmologists still do not use it sufficiently, the frequency of its application during the first visit to the doctor for glaucoma varies from 17.96 to 45.9%. There are also additional instrumental methods of examination of patients with glaucoma that allow an objective assessment of the structures of the eye anterior segment: automated gonioscopy, optical coherence tomography of the eye anterior segment and ultrasound biomicroscopy. These methods can be used both for the primary diagnosis of glaucoma and its dynamic observation, as well as for choosing surgical treatment tactics and monitoring its results thanks to high-precision visualisation and image documentation. Each of them has its own characteristics, advantages and disadvantages, depending on the specifics of the disease and the presence of concomitant ocular pathology, which are described in this article. Conclusion. Taking into account the variety of clinical forms of glaucoma and the insufficient equipment of medical institutions, especially primary care, it can be concluded that it is necessary to improve diagnostic algorithms. Methods such as electronic gonioscopy, optical coherence tomography of the eye anterior segment and ultrasound biomicroscopy will make the diagnostic process more accurate and informative, help to correctly diagnose and determine treatment tactics for both primary care physicians and surgeons. The possibility of documenting the results obtained and creating a system for their analysis can contribute to the founding of a generalized database, which will greatly simplify and accelerate the process of providing care to patients with glaucoma. Key words: glaucoma, anterior chamber angle, gonioscopy, electronic gonioscopy, optical coherence tomography, ultrasound biomicroscopy","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115420135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.25276/0235-4160-2022-1-39-48
I. G. Trifanenkova, A. V. Tereshchenko, E. Erohina
Purpose. To identify the structural and microvascular changes in the retina in children with aggressive posterior retinopathy of prematurity (ROP) with early and pronounced clinical features using spectral optical coherence tomography (SOCT) with angiography function. Material and methods. SOCT was performed in 40 premature infants (40 eyes) with aggressive posterior ROP, born at 25–28 weeks gestation, with a birth weight of 680–1350 g. 15 infants had early clinical features, optical coherence tomography with angiography function (OCT-A) was performed in 4. 25 infants had pronounced clinical features, OCT-A was performed in 3. The comparison group included 10 premature infants (10 eyes) without signs of ROP, as well as 23 children (23 eyes) with an unfavorable type of stage 3 of classical active ROP. Results. Early clinical features of aggressive posterior ROP were characterized by the absence of an avascular zone in fovea, vasodilation of the superficial and deep retinal plexus, the presence of intraretinal neovascularization in the perifovea, and multiple arteriolo-venular shunts. The severity of the pathological process in children with pronounced clinical features of aggressive posterior ROP reflected the development of massive neovascularization affecting all structures of the vitreoretinal interface, as well as the presence of areas of retinoschisis, indicating a high risk of the retinal detachment. Conclusion. The studies revealed gross structural and microvascular retinal pathology in children with aggressive posterior ROP at an early stage already, which indicates the indisputable importance of the earliest diagnosis, and, consequently, earlier treatment, which plays a key role in creating favorable conditions for the visual functions development. Key words: spectral optical coherence tomography-angiography, aggressive posterior retinopathy of prematurity
{"title":"Spectral optical coherence tomography-angiography for structural and microcirculatory retinal disorders assessment in aggressive posterior retinopathy of prematurity","authors":"I. G. Trifanenkova, A. V. Tereshchenko, E. Erohina","doi":"10.25276/0235-4160-2022-1-39-48","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-1-39-48","url":null,"abstract":"Purpose. To identify the structural and microvascular changes in the retina in children with aggressive posterior retinopathy of prematurity (ROP) with early and pronounced clinical features using spectral optical coherence tomography (SOCT) with angiography function. Material and methods. SOCT was performed in 40 premature infants (40 eyes) with aggressive posterior ROP, born at 25–28 weeks gestation, with a birth weight of 680–1350 g. 15 infants had early clinical features, optical coherence tomography with angiography function (OCT-A) was performed in 4. 25 infants had pronounced clinical features, OCT-A was performed in 3. The comparison group included 10 premature infants (10 eyes) without signs of ROP, as well as 23 children (23 eyes) with an unfavorable type of stage 3 of classical active ROP. Results. Early clinical features of aggressive posterior ROP were characterized by the absence of an avascular zone in fovea, vasodilation of the superficial and deep retinal plexus, the presence of intraretinal neovascularization in the perifovea, and multiple arteriolo-venular shunts. The severity of the pathological process in children with pronounced clinical features of aggressive posterior ROP reflected the development of massive neovascularization affecting all structures of the vitreoretinal interface, as well as the presence of areas of retinoschisis, indicating a high risk of the retinal detachment. Conclusion. The studies revealed gross structural and microvascular retinal pathology in children with aggressive posterior ROP at an early stage already, which indicates the indisputable importance of the earliest diagnosis, and, consequently, earlier treatment, which plays a key role in creating favorable conditions for the visual functions development. Key words: spectral optical coherence tomography-angiography, aggressive posterior retinopathy of prematurity","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125970216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.25276/0235-4160-2022-1-77-96
B. Malyugin, S. Sakhnov, L. Axenova, V. Myasnikova
Introduction. Artificial Intelligence is new theoretical approaches, methods, technologies and applied systems for modeling and extending human intelligence. In ophthalmology, artificial intelligence is one of the tools that help improve the efficiency of the treatment process through more accurate diagnostics, search for new biomarkers of diseases, automation of decision-making processes and assistance in other aspects of the physician‘s daily activities. The purpose of this review is to describe the currently available developments for the diagnosis and surgery of keratoconus in the field of artificial intelligence. Material and methods. Databases that were used for literature search included: Google and Google Scholar, PubMed, Embase, MEDLINE and Web of Science. Results. As a result of a search across all selected databases, as well as a selection of relevant studies, 75 articles were analyzed. Most of the studies that were selected for full-text analysis were the development of diagnostic algorithms. The most common classical machine learning methods were support vector machines method and random forest method. The most commonly used type of neural network is the convolutional neural network. 4 studies out of 75 reported the creation of a graphical interface for using the developed algorithm in a clinical environment. Conclusion. The accuracy of the algorithms that were obtained in the analyzed researches was basically more than 90%. It indicates the ability of machine learning models to solve complex clinical problems. Key words: artificial intelligence, machine learning, keratoconus, diagnostics
介绍。人工智能是建模和扩展人类智能的新的理论途径、方法、技术和应用系统。在眼科，人工智能是通过更准确的诊断、寻找新的疾病生物标志物、决策过程的自动化以及在医生日常活动的其他方面提供帮助来提高治疗过程效率的工具之一。本文综述了人工智能在圆锥角膜的诊断和手术方面的最新进展。材料和方法。用于文献检索的数据库包括:Google和Google Scholar、PubMed、Embase、MEDLINE和Web of Science。结果。通过对所有选定数据库的搜索以及相关研究的选择，分析了75篇文章。选择全文分析的大多数研究都是诊断算法的发展。最常用的经典机器学习方法是支持向量机方法和随机森林方法。最常用的神经网络类型是卷积神经网络。75项研究中有4项报告了在临床环境中使用所开发算法的图形界面的创建。结论。所分析的研究中得到的算法的准确率基本在90%以上。它表明了机器学习模型解决复杂临床问题的能力。关键词:人工智能，机器学习，圆锥角膜，诊断
{"title":"Application of artificial intelligence in diagnostics and surgery of keratoconus: a systematic overview","authors":"B. Malyugin, S. Sakhnov, L. Axenova, V. Myasnikova","doi":"10.25276/0235-4160-2022-1-77-96","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-1-77-96","url":null,"abstract":"Introduction. Artificial Intelligence is new theoretical approaches, methods, technologies and applied systems for modeling and extending human intelligence. In ophthalmology, artificial intelligence is one of the tools that help improve the efficiency of the treatment process through more accurate diagnostics, search for new biomarkers of diseases, automation of decision-making processes and assistance in other aspects of the physician‘s daily activities. The purpose of this review is to describe the currently available developments for the diagnosis and surgery of keratoconus in the field of artificial intelligence. Material and methods. Databases that were used for literature search included: Google and Google Scholar, PubMed, Embase, MEDLINE and Web of Science. Results. As a result of a search across all selected databases, as well as a selection of relevant studies, 75 articles were analyzed. Most of the studies that were selected for full-text analysis were the development of diagnostic algorithms. The most common classical machine learning methods were support vector machines method and random forest method. The most commonly used type of neural network is the convolutional neural network. 4 studies out of 75 reported the creation of a graphical interface for using the developed algorithm in a clinical environment. Conclusion. The accuracy of the algorithms that were obtained in the analyzed researches was basically more than 90%. It indicates the ability of machine learning models to solve complex clinical problems. Key words: artificial intelligence, machine learning, keratoconus, diagnostics","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117145143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.25276/0235-4160-2022-1-6-12
P. Maharramov
Relevance. Today, the problem is particularly relevant for cases of keratoconus combined with high refractive ametropia. An extensive review of protocols for the combined use of corneal cross-linking (CXL) in combination with photorefractive keratotomy (PRK), phototherapeutic keratectomy (FTC), IRS, and phakic intraocular lens implantation shows that these protocols require further research to prove the best treatment options. Purpose. To evaluate the effectiveness of the fourstage model of surgical treatment of keratoconus in combination with high refractive ametropia. Material and methods. Between 2016 and 2019, 16 patients (22 eyes) aged 18 to 40 years were operated on using the four-step procedure including intrastromal corneal segments (ICRS) implantation, CXL the next day after the surgery, phakic toric lens implantation (Visian ICL STAAR, implantable collamer lens) 8 months after the surgery, and transepithelial topographic PRK 6 months after the surgery. The study group included patients with keratoconus stage II–III according to the classification of Amsler M. (1961). Patients were examined before, 10 days, 1, 3, 6, 8 and 12 months after the surgery according to a unified program, including determination of visual acuity without (NCVA) and with maximum correction (MCVA), autorefractometry (TOMEY RC-5000), non-contact tonometry (TOMEY FT-1000), Pentacam corneal topography, Wavelight Oculyzer (ALCON), Topolyzer VARIO tomography (ALCON), OCT of the anterior segment Cirrus HD-OCT 5000 (Zeiss, Germany). Results. Indicators of NCVA (M±SD) before and after the 1st operation were 0.02±0.015 and 0.08±0.022 (p=0.05). After the 2nd operation, the NCVA (0.10±0.025) didn‘t change significantly, after the 3rd operation its value increased more than 4 times (0.42±0.11). After the 4th operation, a statistically significant increase in NCVA was observed (0.58±0.12). Conclusion. In patients aged 18 to 40 years with progression of keratoconus, with high myopia, due to the inexpediency of excimer laser operations and where the depth of the anterior chamber isn‘t less than 3 mm, the combined four-stage method of treating keratoconus can be performed as a more effective method. This method allows to avoid keratoplasty, preserving and correcting the irregularity of the own cornea. Key words: keratoconus, refractive surgery, Visian ICL STAAR, topographic PRK, CXL
{"title":"Four-step treatment of keratoconus associated with high refractive ametropia","authors":"P. Maharramov","doi":"10.25276/0235-4160-2022-1-6-12","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-1-6-12","url":null,"abstract":"Relevance. Today, the problem is particularly relevant for cases of keratoconus combined with high refractive ametropia. An extensive review of protocols for the combined use of corneal cross-linking (CXL) in combination with photorefractive keratotomy (PRK), phototherapeutic keratectomy (FTC), IRS, and phakic intraocular lens implantation shows that these protocols require further research to prove the best treatment options. Purpose. To evaluate the effectiveness of the fourstage model of surgical treatment of keratoconus in combination with high refractive ametropia. Material and methods. Between 2016 and 2019, 16 patients (22 eyes) aged 18 to 40 years were operated on using the four-step procedure including intrastromal corneal segments (ICRS) implantation, CXL the next day after the surgery, phakic toric lens implantation (Visian ICL STAAR, implantable collamer lens) 8 months after the surgery, and transepithelial topographic PRK 6 months after the surgery. The study group included patients with keratoconus stage II–III according to the classification of Amsler M. (1961). Patients were examined before, 10 days, 1, 3, 6, 8 and 12 months after the surgery according to a unified program, including determination of visual acuity without (NCVA) and with maximum correction (MCVA), autorefractometry (TOMEY RC-5000), non-contact tonometry (TOMEY FT-1000), Pentacam corneal topography, Wavelight Oculyzer (ALCON), Topolyzer VARIO tomography (ALCON), OCT of the anterior segment Cirrus HD-OCT 5000 (Zeiss, Germany). Results. Indicators of NCVA (M±SD) before and after the 1st operation were 0.02±0.015 and 0.08±0.022 (p=0.05). After the 2nd operation, the NCVA (0.10±0.025) didn‘t change significantly, after the 3rd operation its value increased more than 4 times (0.42±0.11). After the 4th operation, a statistically significant increase in NCVA was observed (0.58±0.12). Conclusion. In patients aged 18 to 40 years with progression of keratoconus, with high myopia, due to the inexpediency of excimer laser operations and where the depth of the anterior chamber isn‘t less than 3 mm, the combined four-stage method of treating keratoconus can be performed as a more effective method. This method allows to avoid keratoplasty, preserving and correcting the irregularity of the own cornea. Key words: keratoconus, refractive surgery, Visian ICL STAAR, topographic PRK, CXL","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122381171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.25276/0235-4160-2022-1-13-18
S. Borzenok, S. V. Kostenev, A. Doga, V. Li, D. Ostrovskiy, M. Khubetsova
Relevance. In recent years, due to the shortage of donor corneas, the need to creating conditions for storing stromal lenticules in eye banks for their clinical use in ophthalmosurgery have been actively discussed. Currently, scientists are looking for optimal conditions for storage native lenticules. There were no reports of storage of decellularized lenticules in the literature. Purpose. To develop optimal conditions for cryopreservation of stromal tissue-engineered constructs for the subsequent creation of a cryobank. Material and methods. The optical properties of native lenticules and tissue–engineered corneal constructs (TCs) were assessed using spectrophotometry. We used a decellularization protocol with 1.5 M NaCl with DNase 5 U/ml and RNase 5 U/ml to create TC. Dispersed viscoelastic agent approved for clinical use in ophthalmology was used for dehydration of TC. Three comparison groups were formed: 1st – control group (native lenticules), 2nd – group without dehydration of TC, 3rd – group with dehydration of TC. The spectrophotometer data was evaluated in 2 stages. The transparency of the control group was measured at 1 stage. At the second stage, the transparency of two experimental groups after storage in DMSO was investigated (a group without dehydration of TC and a group with dehydration of TC). Results. When compared between groups without dehydration of TC; with dehydration of TC and the control group (p≥0.05), no statistical difference was revealed, and when comparing groups without dehydration of TC and groups with dehydration of TC (p≥0.05), no statistical difference was revealed. Conclusion. Groups with dehydration of TC and without dehydration of TC after storage in DMSO did not differ in transparency. In this regard, these groups should be considered as interchangeable in terms of optical properties. Key words: storage, cryopreservation, lenticule, cornea, decellularization, tissue engineering
的相关性。近年来，由于供体角膜的短缺，创造条件在眼库中储存基质晶状体以供临床眼科手术使用的必要性被积极讨论。目前，科学家们正在寻找储存原生透镜体的最佳条件。文献中没有关于脱细胞透镜体储存的报道。目的。建立基质组织工程构建物低温保存的最佳条件，为后续建立冷冻库奠定基础。材料和方法。采用分光光度法对天然角膜晶状体和组织工程角膜构建体(TCs)的光学特性进行了评价。我们使用1.5 M NaCl和DNase 5 U/ml和RNase 5 U/ml的脱细胞方案来创建TC。应用眼科临床批准的分散粘弹性剂治疗TC脱水。将其分为3个对照组:第1组(天然小晶状体)、第2组(未脱水)、第3组(脱水)。分光光度计数据分2个阶段进行评价。对照组于1期测定透明度。在第二阶段，研究两个实验组(未脱水组和脱水组)在DMSO中储存后的透明度。结果。未脱水TC组间比较;TC脱水组与对照组比较，差异无统计学意义(p≥0.05);TC未脱水组与TC脱水组比较，差异无统计学意义(p≥0.05)。结论。脱水组和未脱水组在DMSO中保存后的透明度没有差异。在这方面，这些基团在光学性质方面应该被认为是可互换的。关键词:贮藏，冷冻保存，角膜，脱细胞，组织工程
{"title":"Development optimal conditions for cryopreservation of tissue-engineered corneal constructs","authors":"S. Borzenok, S. V. Kostenev, A. Doga, V. Li, D. Ostrovskiy, M. Khubetsova","doi":"10.25276/0235-4160-2022-1-13-18","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-1-13-18","url":null,"abstract":"Relevance. In recent years, due to the shortage of donor corneas, the need to creating conditions for storing stromal lenticules in eye banks for their clinical use in ophthalmosurgery have been actively discussed. Currently, scientists are looking for optimal conditions for storage native lenticules. There were no reports of storage of decellularized lenticules in the literature. Purpose. To develop optimal conditions for cryopreservation of stromal tissue-engineered constructs for the subsequent creation of a cryobank. Material and methods. The optical properties of native lenticules and tissue–engineered corneal constructs (TCs) were assessed using spectrophotometry. We used a decellularization protocol with 1.5 M NaCl with DNase 5 U/ml and RNase 5 U/ml to create TC. Dispersed viscoelastic agent approved for clinical use in ophthalmology was used for dehydration of TC. Three comparison groups were formed: 1st – control group (native lenticules), 2nd – group without dehydration of TC, 3rd – group with dehydration of TC. The spectrophotometer data was evaluated in 2 stages. The transparency of the control group was measured at 1 stage. At the second stage, the transparency of two experimental groups after storage in DMSO was investigated (a group without dehydration of TC and a group with dehydration of TC). Results. When compared between groups without dehydration of TC; with dehydration of TC and the control group (p≥0.05), no statistical difference was revealed, and when comparing groups without dehydration of TC and groups with dehydration of TC (p≥0.05), no statistical difference was revealed. Conclusion. Groups with dehydration of TC and without dehydration of TC after storage in DMSO did not differ in transparency. In this regard, these groups should be considered as interchangeable in terms of optical properties. Key words: storage, cryopreservation, lenticule, cornea, decellularization, tissue engineering","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129789042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.25276/0235-4160-2022-1-26-32
V. D. Antonuk, O. Kuranova, T. S. Kuznetsova
Purpose. To assess the state of blood flow in the limbal area in patients with myopia and myopic astigmatism before and after excimer laser vision correction using the Nidek RS-3000 AngioScan optical coherence tomograph. Material and methods. A total of 22 patients aged 18 to 37 with different degrees of myopia and myopic astigmatism who underwent excimer laser vision correction were examined. Additionally, the blood flow of the limbal area was studied in the preoperative and early postoperative periods using the Nidek RS-3000 AngioScan optical coherence tomograph using a module for scanning the anterior segment of the eye. Results. One hour after excimer laser vision correction, there is a decrease in blood flow of the limbal area in all 4 analyzed sectors (upper, lower, temporal, nasal), after 1 day there is an increase in blood flow indicators, tending to preoperative values. We were unable to identify the dependence of the degree of blood flow on the method of formation of the corneal flap. Conclusion. Using OCT angioregime it is possible to assess the condition of limb blood flow. In the first hour after laser vision correction blood flow parameters change in all 4 studied sectors, with a tendency to decrease, and recover to preoperative values 1 day after the surgery. Key words: optical coherent angiography of the limbal area, excimer laser vision correction, femtolaser vision correction, myopia, myopic astigmatism.
{"title":"Assessment of blood flow parameters of the limbal area using an angioregime optical coherence tomograph in patients with myopia and myopic astigmatism who underwent excimer laser vision correction","authors":"V. D. Antonuk, O. Kuranova, T. S. Kuznetsova","doi":"10.25276/0235-4160-2022-1-26-32","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-1-26-32","url":null,"abstract":"Purpose. To assess the state of blood flow in the limbal area in patients with myopia and myopic astigmatism before and after excimer laser vision correction using the Nidek RS-3000 AngioScan optical coherence tomograph. Material and methods. A total of 22 patients aged 18 to 37 with different degrees of myopia and myopic astigmatism who underwent excimer laser vision correction were examined. Additionally, the blood flow of the limbal area was studied in the preoperative and early postoperative periods using the Nidek RS-3000 AngioScan optical coherence tomograph using a module for scanning the anterior segment of the eye. Results. One hour after excimer laser vision correction, there is a decrease in blood flow of the limbal area in all 4 analyzed sectors (upper, lower, temporal, nasal), after 1 day there is an increase in blood flow indicators, tending to preoperative values. We were unable to identify the dependence of the degree of blood flow on the method of formation of the corneal flap. Conclusion. Using OCT angioregime it is possible to assess the condition of limb blood flow. In the first hour after laser vision correction blood flow parameters change in all 4 studied sectors, with a tendency to decrease, and recover to preoperative values 1 day after the surgery. Key words: optical coherent angiography of the limbal area, excimer laser vision correction, femtolaser vision correction, myopia, myopic astigmatism.","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"163 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134217270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.25276/0235-4160-2022-1-71-76
O. V. Kolenko, M. V. Pshenichnov, E. L. Sorokin
Purpose. To analyze changes in work of the Khabarovsk branch of the Fyodorov Eye Microsurgery Federal State Institution (Khabarovsk branch) caused by combination of elective and emergency ophthalmic care in the context of a pandemic of the novel coronavirus disease (COVID-19). Material and methods. The article presents the organizational restructuring of activities medical units of the Khabarovsk branch, due to need for additional performance of functions emergency ophthalmological service in connection with closure of the regional ophthalmological center of the City Clinical Hospital no. 10, which previously performed this function. Complex of organizational anti-epidemic measures taken to prevent the spread of COVID-19 in pandemic is presented, their feasibility is analyzed, the results of the clinic‘s activities in new conditions of the COVID-19 pandemic are reflected. Results. The COVID-19 epidemic required a significant organizational restructuring of the Khabarovsk branch. In addition to large volumes of elective surgery, emergency ophthalmosurgical care was added, performed in a round-the-clock hospital. All this was superimposed on the organizational restructuring of patient flows, created to minimize their interpersonal contacts. Conclusion. The Khabarovsk branch fully coped with the tasks set, stable work was organized in the new pandemic conditions, effectively combining planned and emergency algorithms of ophthalmic surgical care. The measures taken made it possible to provide emergency ophthalmic care in full throughout the entire period of the epidemic, to resume the provision of planned ophthalmic care in full, without compromising the safety of patients‘ stay in the clinic. Key words: COVID-19, SARS-CoV-2, pandemic, emergency care, eye emergency department, Eye casualty, coronavirus disease, organization of medical care
{"title":"Restructuring algorithms of work in eye surgery clinic during pandemic of the novel coronavirus disease (COVID-19)","authors":"O. V. Kolenko, M. V. Pshenichnov, E. L. Sorokin","doi":"10.25276/0235-4160-2022-1-71-76","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-1-71-76","url":null,"abstract":"Purpose. To analyze changes in work of the Khabarovsk branch of the Fyodorov Eye Microsurgery Federal State Institution (Khabarovsk branch) caused by combination of elective and emergency ophthalmic care in the context of a pandemic of the novel coronavirus disease (COVID-19). Material and methods. The article presents the organizational restructuring of activities medical units of the Khabarovsk branch, due to need for additional performance of functions emergency ophthalmological service in connection with closure of the regional ophthalmological center of the City Clinical Hospital no. 10, which previously performed this function. Complex of organizational anti-epidemic measures taken to prevent the spread of COVID-19 in pandemic is presented, their feasibility is analyzed, the results of the clinic‘s activities in new conditions of the COVID-19 pandemic are reflected. Results. The COVID-19 epidemic required a significant organizational restructuring of the Khabarovsk branch. In addition to large volumes of elective surgery, emergency ophthalmosurgical care was added, performed in a round-the-clock hospital. All this was superimposed on the organizational restructuring of patient flows, created to minimize their interpersonal contacts. Conclusion. The Khabarovsk branch fully coped with the tasks set, stable work was organized in the new pandemic conditions, effectively combining planned and emergency algorithms of ophthalmic surgical care. The measures taken made it possible to provide emergency ophthalmic care in full throughout the entire period of the epidemic, to resume the provision of planned ophthalmic care in full, without compromising the safety of patients‘ stay in the clinic. Key words: COVID-19, SARS-CoV-2, pandemic, emergency care, eye emergency department, Eye casualty, coronavirus disease, organization of medical care","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123940084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.25276/0235-4160-2022-1-59-70
E. Myakoshina
Purpose. To assess the survival rate of patients with small and mediumsized uveal melanoma, depending on the clinical and pathomorphological picture and the cellular microenvironment. Material and methods. For a prospective study, 33 patients with T1-2N0M0 stage of the tumor were selected for the period from June 2005 to July 2018 at an average age of 54±2.7 years. In all cases, the enucleation of the affected eye was carried out with a morphological study of it and a study of the composition of the cellular microenvironment of the tumor node, which became the main criterion for compliance and inclusion in the study. Results. During the study period of observation after enucleation due to eye uveal tract melanoma, 9 (27.3%) of 33 patients died from metastatic disease. Of these, 2 with small and 7 with middle size of tumor. The timing of the appearance of metastases ranged from 15 to 96 (average 41.3±34.5) months. The median follow-up was 64.5 (95% confidence interval 29.3– 99.7) month. The 5-year survival rate of patients with small and medium sized uveal melanoma was 78.7%, and the 10-year survival rate was 72.7%. A significant dependence of the mortality of patients was revealed with the epithelioid cell type of melanoma, increase of tumor basal diameter, involvement of optic disc area and ciliary body, a significant degree of pigmentation, the presence of necrosis in tumor stroma, ingrowth into sclera emissarium and large number of tumor vessels. Survival decreases in patients with a large accumulation of lymphocytes around the tumor, the absence of macrophages, mast cells, fibroblasts on the one hand, and the presence of plasmocytes, myeloid-derived suppressor cells (promyelocytes, neutrophils, eosinophils) in tumor microenvironment. Conclusion. Studies have revealed a certain relationship between the life expectancy of patients and their mortality from metastatic disease with clinical and pathological signs and a specific composition of the cell microenvironment. Key words: uveal melanoma, survival, cell microenvironment
{"title":"Survival of patients with small and medium-sized uveal melanoma depending on pathomorphological picture and cellular microenvironment","authors":"E. Myakoshina","doi":"10.25276/0235-4160-2022-1-59-70","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-1-59-70","url":null,"abstract":"Purpose. To assess the survival rate of patients with small and mediumsized uveal melanoma, depending on the clinical and pathomorphological picture and the cellular microenvironment. Material and methods. For a prospective study, 33 patients with T1-2N0M0 stage of the tumor were selected for the period from June 2005 to July 2018 at an average age of 54±2.7 years. In all cases, the enucleation of the affected eye was carried out with a morphological study of it and a study of the composition of the cellular microenvironment of the tumor node, which became the main criterion for compliance and inclusion in the study. Results. During the study period of observation after enucleation due to eye uveal tract melanoma, 9 (27.3%) of 33 patients died from metastatic disease. Of these, 2 with small and 7 with middle size of tumor. The timing of the appearance of metastases ranged from 15 to 96 (average 41.3±34.5) months. The median follow-up was 64.5 (95% confidence interval 29.3– 99.7) month. The 5-year survival rate of patients with small and medium sized uveal melanoma was 78.7%, and the 10-year survival rate was 72.7%. A significant dependence of the mortality of patients was revealed with the epithelioid cell type of melanoma, increase of tumor basal diameter, involvement of optic disc area and ciliary body, a significant degree of pigmentation, the presence of necrosis in tumor stroma, ingrowth into sclera emissarium and large number of tumor vessels. Survival decreases in patients with a large accumulation of lymphocytes around the tumor, the absence of macrophages, mast cells, fibroblasts on the one hand, and the presence of plasmocytes, myeloid-derived suppressor cells (promyelocytes, neutrophils, eosinophils) in tumor microenvironment. Conclusion. Studies have revealed a certain relationship between the life expectancy of patients and their mortality from metastatic disease with clinical and pathological signs and a specific composition of the cell microenvironment. Key words: uveal melanoma, survival, cell microenvironment","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130733462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.25276/0235-4160-2022-1-54-58
D. Shkvorchenko, E. S. Khrisanfova, S. A. Kakunina, A. S. Zhuravlev, D. G. Uzunyan
Relevance. There are many causes of spontaneous hemorrhage into the vitreous cavity. Sometimes spontaneous nontraumatic vitreous hemorrhage can be rhegmatogenous in nature, occurring as a result of a ruptured retinal vessel running through the site of a retinal tear. Usually, a patient with spontaneous nontraumatic vitreous hemorrhage is managed with a conservative approach, but it is questionable whether conservative management of patients with this pathology is advisable. Purpose. To evaluate the results of surgical treatment of patients with idiopathic, presumably rhegmatogenous vitreous hemorrhage. Material and methods. Surgical treatment of 10 patients diagnosed with idiopathic vitreous hemorrhage, presumably of rhegmatogenous nature, was performed and the results of treatment were evaluated. The best corrected visual acuity (BCVA) before treatment was on average 0.03. Slit lamp examination revealed dispersed vitreous hemorrhage into the vitreous body with a total obscuration of the posterior pole. According to B-scan data there was no retinal detachment in all cases. All patients underwent surgical treatment. Results. By the third month of follow-up after surgical treatment, visual acuity was 0.9±0.04 on average. B-scan data showed no pathology in all cases. Light sensitivity was 28.7±0.15 dB on average. Conclusion. If other obvious causes of vitreous hemorrhage are excluded, urgent surgical treatment is, in our opinion, the most preferable approach and can be recommended as a first line of treatment instead of conservative therapy. Key words: vitreous hemorrhage, conservative treatment, vitreoretinal surgery, retinal tear, ultrasound diagnostics
{"title":"Surgical management of spontaneous vitreous hemorrhage, presumably of rhegmatogenous origin","authors":"D. Shkvorchenko, E. S. Khrisanfova, S. A. Kakunina, A. S. Zhuravlev, D. G. Uzunyan","doi":"10.25276/0235-4160-2022-1-54-58","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-1-54-58","url":null,"abstract":"Relevance. There are many causes of spontaneous hemorrhage into the vitreous cavity. Sometimes spontaneous nontraumatic vitreous hemorrhage can be rhegmatogenous in nature, occurring as a result of a ruptured retinal vessel running through the site of a retinal tear. Usually, a patient with spontaneous nontraumatic vitreous hemorrhage is managed with a conservative approach, but it is questionable whether conservative management of patients with this pathology is advisable. Purpose. To evaluate the results of surgical treatment of patients with idiopathic, presumably rhegmatogenous vitreous hemorrhage. Material and methods. Surgical treatment of 10 patients diagnosed with idiopathic vitreous hemorrhage, presumably of rhegmatogenous nature, was performed and the results of treatment were evaluated. The best corrected visual acuity (BCVA) before treatment was on average 0.03. Slit lamp examination revealed dispersed vitreous hemorrhage into the vitreous body with a total obscuration of the posterior pole. According to B-scan data there was no retinal detachment in all cases. All patients underwent surgical treatment. Results. By the third month of follow-up after surgical treatment, visual acuity was 0.9±0.04 on average. B-scan data showed no pathology in all cases. Light sensitivity was 28.7±0.15 dB on average. Conclusion. If other obvious causes of vitreous hemorrhage are excluded, urgent surgical treatment is, in our opinion, the most preferable approach and can be recommended as a first line of treatment instead of conservative therapy. Key words: vitreous hemorrhage, conservative treatment, vitreoretinal surgery, retinal tear, ultrasound diagnostics","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"147 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134262515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.25276/0235-4160-2022-1-33-38
P. L. Volodin, E. V. Ivanova, Yuliya I. Kukharskaya
Purpose. To study methods of using antiangiogenic therapy in combination with combined navigational laser treatment in patients with MO due to BRVO. Material and methods. The study included 99 patients with ME due to BRVO, the main group (n=54) consisted of patients treated using the combined technique, the control group – patients treated with ranibizumab monotherapy (n=45). The combined method for the treatment of ME due to BRVO included the initial intravitreal injection of ranibizumab. 2 weeks after the injection, the patients carry out OCT, in the presence of central retinal thickness (CRT) more than 350 μm, 1 month after injection, one or more injections of ranibizumab were performed until the CRT reached 350 μm or less, when the «target» level was reached, combined navigation laser treatment was performed. Results. 1 month after the combined laser treatment, the best corrected visual acuity (BCVA) was 0.67±0.14 (on average), the CRT, on the average for the group, was 311.9 114.5 μm, the central retinal sensitivity was 22.3±1.6 dB. After 3 months, BCVA was 0.71±0.14, CRT was 289.9±110.5 μm, central retinal sensitivity was 22.8±1.6 dB. After 6 months, BCVA was 0.74±0.14, CRT was 236.5±107.6 μm, central retinal sensitivity was 23.1±1.5 dB. At follow-up period of 1 year in the main group was required on average, 3.47±1.58 injections of ranibizumab for stabilization, in the control group, on average, 4.36±1.58 injections were required, the average indicators of BCVA and CRT significantly did not differ. Conclusion. Navigational combined laser treatment in combination with antiangiogenic therapy has shown its effectiveness and safety in the treatment of macular edema due to the branch retinal vein occlusion. The effectiveness of the combined laser technology is expressed in positive dynamics in all functional and morphometric parameters. The safety of the proposed technology is expressed in the absence of clinically significant intra- and postoperative complications. Key words: navigation laser technology, micropulse mode, retinal vein occlusion, macular edema, antiangiogenic therapy
{"title":"Evaluation of the efficacy and safety of navigational combined laser treatment in combination with antiangiogenic therapy in macular edema due to the branch retinal vein occlusion","authors":"P. L. Volodin, E. V. Ivanova, Yuliya I. Kukharskaya","doi":"10.25276/0235-4160-2022-1-33-38","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-1-33-38","url":null,"abstract":"Purpose. To study methods of using antiangiogenic therapy in combination with combined navigational laser treatment in patients with MO due to BRVO. Material and methods. The study included 99 patients with ME due to BRVO, the main group (n=54) consisted of patients treated using the combined technique, the control group – patients treated with ranibizumab monotherapy (n=45). The combined method for the treatment of ME due to BRVO included the initial intravitreal injection of ranibizumab. 2 weeks after the injection, the patients carry out OCT, in the presence of central retinal thickness (CRT) more than 350 μm, 1 month after injection, one or more injections of ranibizumab were performed until the CRT reached 350 μm or less, when the «target» level was reached, combined navigation laser treatment was performed. Results. 1 month after the combined laser treatment, the best corrected visual acuity (BCVA) was 0.67±0.14 (on average), the CRT, on the average for the group, was 311.9 114.5 μm, the central retinal sensitivity was 22.3±1.6 dB. After 3 months, BCVA was 0.71±0.14, CRT was 289.9±110.5 μm, central retinal sensitivity was 22.8±1.6 dB. After 6 months, BCVA was 0.74±0.14, CRT was 236.5±107.6 μm, central retinal sensitivity was 23.1±1.5 dB. At follow-up period of 1 year in the main group was required on average, 3.47±1.58 injections of ranibizumab for stabilization, in the control group, on average, 4.36±1.58 injections were required, the average indicators of BCVA and CRT significantly did not differ. Conclusion. Navigational combined laser treatment in combination with antiangiogenic therapy has shown its effectiveness and safety in the treatment of macular edema due to the branch retinal vein occlusion. The effectiveness of the combined laser technology is expressed in positive dynamics in all functional and morphometric parameters. The safety of the proposed technology is expressed in the absence of clinically significant intra- and postoperative complications. Key words: navigation laser technology, micropulse mode, retinal vein occlusion, macular edema, antiangiogenic therapy","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123950653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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