Pub Date : 2022-12-19DOI: 10.25276/0235-4160-2022-4-13-17
G. A. Fedyashev, D. A. Khvan, M. P. Ruchkin
Purpose. The article presents a clinical case of cataract surgery with implantation and preoperative calculation of the AcrySof IQ Vivity intraocular lens (IOL) (Alcon, USA) in a patient who underwent penetrating keratoplasty 15 months ago. Material and methods. IOL calculation was based on the actual data of the optical biometry, keratotopographic measurements. Considering complaints, a decrease in the quality of life, ophthalmic status data, it was decided to perform a penetrating subtotal keratoplasty of the right eye, followed by remote phacoemulsification and implantation of an intraocular lens. Results. Patient reports good quality of vision at a distance and average distance; does not experience difficulties when working with computer, feels comfortable while driving at night. Conclusion. Delayed cataract surgery with IOL implantation with the wavefront formation mechanism after penetrating subtotal keratoplasty, only in cases of donor material stabilization, allows to get accurate refraction. Even despite the high probability of refractive error, this type and design features of the lens made it possible to obtain the optimal quality of vision for the patient. Keywords: penetrating keratoplasty, cataract, intraocular lens, refractive error.
{"title":"Implantation of an intraocular lens with a wavefront formation mechanism in the surgical treatment of cataracts in patients after penetrating keratoplasty","authors":"G. A. Fedyashev, D. A. Khvan, M. P. Ruchkin","doi":"10.25276/0235-4160-2022-4-13-17","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-4-13-17","url":null,"abstract":"Purpose. The article presents a clinical case of cataract surgery with implantation and preoperative calculation of the AcrySof IQ Vivity intraocular lens (IOL) (Alcon, USA) in a patient who underwent penetrating keratoplasty 15 months ago. Material and methods. IOL calculation was based on the actual data of the optical biometry, keratotopographic measurements. Considering complaints, a decrease in the quality of life, ophthalmic status data, it was decided to perform a penetrating subtotal keratoplasty of the right eye, followed by remote phacoemulsification and implantation of an intraocular lens. Results. Patient reports good quality of vision at a distance and average distance; does not experience difficulties when working with computer, feels comfortable while driving at night. Conclusion. Delayed cataract surgery with IOL implantation with the wavefront formation mechanism after penetrating subtotal keratoplasty, only in cases of donor material stabilization, allows to get accurate refraction. Even despite the high probability of refractive error, this type and design features of the lens made it possible to obtain the optimal quality of vision for the patient. Keywords: penetrating keratoplasty, cataract, intraocular lens, refractive error.","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133538974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-19DOI: 10.25276/0235-4160-2022-4-85-91
E. S. Chekhonin, R. Fayzrakhmanov, M. M. Shishkin, M. R. Kalanov
Relevance. The proliferative stage of diabetic retinopathy is characterized by angiogenesis, which is largely mediated by the vascular endothelial growth factor. Peripheral retinal laser coagulation has been standard treatment for PDR for many years, providing control of ischemia and reduction of vascular endothelial growth factor levels with subsequent regression of neovascularization. However, it leads to serious functional deficits and anatomical complications. The advent of antivascular endothelial growth factor (anti-VEGF) agents has changed the future of PDR management and has provided an alternative to pan retinal photocoagulation. Their combination with panretinal photocoagulation may be effective for the treatment of proliferative diabetic retinopathy and concurrent diabetic macular edema. Anti-VEGF therapy also takes place in surgery of complicated PDR. Purpose. To analyze the relevance of the use of anti-VEGF drugs in the treatment of the proliferative stage of diabetic retinopathy. Material and methods. The literature review is written using PubMed, Сochrane Library, 29 literature references published up to 2021. Results. In patients with severe cases, preoperative treatment is a gentle approach for the anatomic structures of the eye, it also contributes to the reduction in the number of intraoperative and postoperative complications. Conclusion. Preoperative treatment is a gentle approach for the anatomic structures of the eye, it also contributes to the reduction in the number of intraoperative and postoperative complications. Key words: anti-VEGF, diabetic macular edema, proliferative diabetic retinopathy.
{"title":"Role of inhibition of angiogenesis in patients with diabetic retinopathy","authors":"E. S. Chekhonin, R. Fayzrakhmanov, M. M. Shishkin, M. R. Kalanov","doi":"10.25276/0235-4160-2022-4-85-91","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-4-85-91","url":null,"abstract":"Relevance. The proliferative stage of diabetic retinopathy is characterized by angiogenesis, which is largely mediated by the vascular endothelial growth factor. Peripheral retinal laser coagulation has been standard treatment for PDR for many years, providing control of ischemia and reduction of vascular endothelial growth factor levels with subsequent regression of neovascularization. However, it leads to serious functional deficits and anatomical complications. The advent of antivascular endothelial growth factor (anti-VEGF) agents has changed the future of PDR management and has provided an alternative to pan retinal photocoagulation. Their combination with panretinal photocoagulation may be effective for the treatment of proliferative diabetic retinopathy and concurrent diabetic macular edema. Anti-VEGF therapy also takes place in surgery of complicated PDR. Purpose. To analyze the relevance of the use of anti-VEGF drugs in the treatment of the proliferative stage of diabetic retinopathy. Material and methods. The literature review is written using PubMed, Сochrane Library, 29 literature references published up to 2021. Results. In patients with severe cases, preoperative treatment is a gentle approach for the anatomic structures of the eye, it also contributes to the reduction in the number of intraoperative and postoperative complications. Conclusion. Preoperative treatment is a gentle approach for the anatomic structures of the eye, it also contributes to the reduction in the number of intraoperative and postoperative complications. Key words: anti-VEGF, diabetic macular edema, proliferative diabetic retinopathy.","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128637108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-19DOI: 10.25276/0235-4160-2022-4-56-64
B. Malyugin, S. Borzenok, D. Ostrovskiy, O. Antonova, M.H. Hubetsova, N. Tsikarishvili
Purpose. Development of method for obtaining a suspension of native human corneal endothelial cells. Material and methods. To obtain a suspension of native endothelial cells, 20 corneoscleral discs isolated from the enucleated eyes of experimental animals (pigs) and 28 cadaveric corneoscleral discs isolated from cadaveric donors (human) were used. In the course of the work, the following isolation methods were used to obtain a cell culture: mechanical, enzymatic, as well as modified versions of these methods proposed during the experiment. Results. It was revealed that mechanical and modified mechanical methods of isolation make it possible to obtain more than 95% of corneal endothelial cells. The use of the enzyme method gave low results, which did not exceed 15% of the isolated endothelial cells, which was explained by the absence of direct mechanical action to separate the cells from the Descemet's membrane (DM). There was no statistically significant difference in the groups of porcine and human corneas for mechanical and enzymatic isolation. The modified enzyme method on human corneas provided 100% isolation of corneal endothelial cells with DM. When analyzing the purity of the suspension, it was found that mechanical and modified mechanical extraction methods do not exclude the ingress of large particles. In the samples obtained by the enzymatic method, these particles were absent. At Comparison of the modified methods for isolating the suspension of endothelial cells revealed their statistically significant difference, in particular, lower rates of contamination with foreign particles were noted with the modified enzyme method. Conclusion. The conducted experimental study is the first stage in the development of an effective and safe method for obtaining suspensions of endothelial cells, for their subsequent cultivation or use in clinical practice to replace defects in the endothelial layer, for example, in patients with bullous keratopathy. Key words: endothelial cells, cultivation, corneal transplantation, endothelial keratoplasty, surgical technique, cell lines.
{"title":"Development of a method for obtaining a suspension of human corneal endothelial cells and its subsequent transplantation in an ex vivo experiment","authors":"B. Malyugin, S. Borzenok, D. Ostrovskiy, O. Antonova, M.H. Hubetsova, N. Tsikarishvili","doi":"10.25276/0235-4160-2022-4-56-64","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-4-56-64","url":null,"abstract":"Purpose. Development of method for obtaining a suspension of native human corneal endothelial cells. Material and methods. To obtain a suspension of native endothelial cells, 20 corneoscleral discs isolated from the enucleated eyes of experimental animals (pigs) and 28 cadaveric corneoscleral discs isolated from cadaveric donors (human) were used. In the course of the work, the following isolation methods were used to obtain a cell culture: mechanical, enzymatic, as well as modified versions of these methods proposed during the experiment. Results. It was revealed that mechanical and modified mechanical methods of isolation make it possible to obtain more than 95% of corneal endothelial cells. The use of the enzyme method gave low results, which did not exceed 15% of the isolated endothelial cells, which was explained by the absence of direct mechanical action to separate the cells from the Descemet's membrane (DM). There was no statistically significant difference in the groups of porcine and human corneas for mechanical and enzymatic isolation. The modified enzyme method on human corneas provided 100% isolation of corneal endothelial cells with DM. When analyzing the purity of the suspension, it was found that mechanical and modified mechanical extraction methods do not exclude the ingress of large particles. In the samples obtained by the enzymatic method, these particles were absent. At Comparison of the modified methods for isolating the suspension of endothelial cells revealed their statistically significant difference, in particular, lower rates of contamination with foreign particles were noted with the modified enzyme method. Conclusion. The conducted experimental study is the first stage in the development of an effective and safe method for obtaining suspensions of endothelial cells, for their subsequent cultivation or use in clinical practice to replace defects in the endothelial layer, for example, in patients with bullous keratopathy. Key words: endothelial cells, cultivation, corneal transplantation, endothelial keratoplasty, surgical technique, cell lines.","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117004891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-19DOI: 10.25276/0235-4160-2022-4-74-84
E. V. Egorova, I. S. Rebrikov
Relevance. Description of the infusion misdirection syndrome (IMS) was first published by R. Mackool in 1993. Nowadays many definitions of this syndrome are used by different authors that sometimes leads to confusion in understanding of clinical situations. Purpose. To summarize current understanding of the etiological factors, the specific pathogenic mechanisms of the infusion misdirection syndrome and possible treatment and prophylaxis methods of this condition. Material and methods. The PubMed web platform was used to find relevant studies since 1992 until 2022 using the following keywords: infusion misdirection syndrome, aqueous misdirection syndrome, intraoperative fluid misdirection syndrome, subcapsular fluid entrapment, acute intraoperative rock-hard eye syndrome. Search query found 167 papers, only 10 papers were relevant for the topic of search. Other publications were also considered as a potential source of information when referenced in relevant articles. Results. Authors of this article support the opinion that IMS etiologically relates to irido-zonular dehiscence and disturbance of the vitreolenticular interface barrier. Manifestations of the IMS include retrocapsular lens fragments migration after uneventful phacoemulsification with intact capsular bag and vitreous hydration. The most severe IMS consequence is the acute intraoperative rock-hard eye syndrome. In intact capsules the zonular dehiscence may enable fluid to flow in an unusual pattern, facilitating its penetration to the posterior chamber. The role of vitreolenticular interface should be mentioned in the aspect of the IMS. Anterior hyaloid membrane detachment or Wieger's ligament destruction are risk factors for IMS development during phacoemulsification. Conclusion. IMS is the object of insufficient research in ophthalmology nowadays. There are many descriptions of IMS in literature, but no solutions to avoid this hidden complication of cataract surgery are proposed. Key words: infusion misdirection syndrome, phacoemulsification, irido-zonular dehiscence, vitreolenticular interface.
{"title":"Infusion misdirection syndrome: current state of issue","authors":"E. V. Egorova, I. S. Rebrikov","doi":"10.25276/0235-4160-2022-4-74-84","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-4-74-84","url":null,"abstract":"Relevance. Description of the infusion misdirection syndrome (IMS) was first published by R. Mackool in 1993. Nowadays many definitions of this syndrome are used by different authors that sometimes leads to confusion in understanding of clinical situations. Purpose. To summarize current understanding of the etiological factors, the specific pathogenic mechanisms of the infusion misdirection syndrome and possible treatment and prophylaxis methods of this condition. Material and methods. The PubMed web platform was used to find relevant studies since 1992 until 2022 using the following keywords: infusion misdirection syndrome, aqueous misdirection syndrome, intraoperative fluid misdirection syndrome, subcapsular fluid entrapment, acute intraoperative rock-hard eye syndrome. Search query found 167 papers, only 10 papers were relevant for the topic of search. Other publications were also considered as a potential source of information when referenced in relevant articles. Results. Authors of this article support the opinion that IMS etiologically relates to irido-zonular dehiscence and disturbance of the vitreolenticular interface barrier. Manifestations of the IMS include retrocapsular lens fragments migration after uneventful phacoemulsification with intact capsular bag and vitreous hydration. The most severe IMS consequence is the acute intraoperative rock-hard eye syndrome. In intact capsules the zonular dehiscence may enable fluid to flow in an unusual pattern, facilitating its penetration to the posterior chamber. The role of vitreolenticular interface should be mentioned in the aspect of the IMS. Anterior hyaloid membrane detachment or Wieger's ligament destruction are risk factors for IMS development during phacoemulsification. Conclusion. IMS is the object of insufficient research in ophthalmology nowadays. There are many descriptions of IMS in literature, but no solutions to avoid this hidden complication of cataract surgery are proposed. Key words: infusion misdirection syndrome, phacoemulsification, irido-zonular dehiscence, vitreolenticular interface.","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130173720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-19DOI: 10.25276/0235-4160-2022-4-26-35
A. Tereshchenko, S. K. Demyanchenko, Y. Vishnyakova
Purpose. To develop a technology for topographically oriented positioning of intrastromal segments during femtolaser intrastromal keratoplasty (ISKP) in patients with keratoconus using a digital marking device and to evaluate its clinical efficacy. Material and methods. The study included 102 patients (102 eyes) with stage II keratoconus according to the Amsler – Krumeich classification. According to the type of surgery performed, the patients were divided into groups: the main group (53 patients (53 eyes) – femtolaser ISKP with implantation of polymethyl methacrylate (PMMA) segments was performed using a digital marking device and taking into account the cyclotorsion angle; control group (49 patients (49 eyes)) – femtolaser ISKP with implantation of PMMA segments was performed using the standard method (marking the geometric center of the cornea using the Purkenier – Sanson reflex without taking into account cyclotorsion). Results. The indices of the «success» index, the calculated vector of astigmatism close to the actual postoperative one and a smaller value of the vector of the difference in the axis of astigmatism, confirmed the higher accuracy of ISKP with the use of a digital marker compared to the standard one. The mean values of visual acuity and best corrected visual acuity 12 months after surgery in the main group were 0.58 ± 0.05 and 0.80 ± 0.04, respectively, and in the control group they were at the level of 0.49 ± 0.06 and 0.68 ± 0.05 respectively. After the surgery, there was a statistically significant decrease in the mean values of astigmatism: the main group – after 3 months to -1.8 ± 0.15 diopters (p <0.05), after 6 months – by another 1.7 ± 0.20 diopters (p <0.05); the control group – after 3 months to -2.43 ± 0.17 diopters (p <0.05), after 6 months – by another 2.42 ± 0.17 diopters. Conclusion. The proposed optimized ISKP technique with the use of a digital marking device provides precise positioning of segments during the surgical treatment of keratoconus and allows to obtain higher acuity of vision and best corrected visual acuity, as well as to correct corneal astigmatism more efficiently than using standard technique. Key words: surgical treatment of keratoconus, femtolaser intrastromal implantation of corneal segments, digital marking device.
{"title":"Femtolaser intrastromal implantation of corneal segments using a digital marking device in the surgical treatment of keratoconus","authors":"A. Tereshchenko, S. K. Demyanchenko, Y. Vishnyakova","doi":"10.25276/0235-4160-2022-4-26-35","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-4-26-35","url":null,"abstract":"Purpose. To develop a technology for topographically oriented positioning of intrastromal segments during femtolaser intrastromal keratoplasty (ISKP) in patients with keratoconus using a digital marking device and to evaluate its clinical efficacy. Material and methods. The study included 102 patients (102 eyes) with stage II keratoconus according to the Amsler – Krumeich classification. According to the type of surgery performed, the patients were divided into groups: the main group (53 patients (53 eyes) – femtolaser ISKP with implantation of polymethyl methacrylate (PMMA) segments was performed using a digital marking device and taking into account the cyclotorsion angle; control group (49 patients (49 eyes)) – femtolaser ISKP with implantation of PMMA segments was performed using the standard method (marking the geometric center of the cornea using the Purkenier – Sanson reflex without taking into account cyclotorsion). Results. The indices of the «success» index, the calculated vector of astigmatism close to the actual postoperative one and a smaller value of the vector of the difference in the axis of astigmatism, confirmed the higher accuracy of ISKP with the use of a digital marker compared to the standard one. The mean values of visual acuity and best corrected visual acuity 12 months after surgery in the main group were 0.58 ± 0.05 and 0.80 ± 0.04, respectively, and in the control group they were at the level of 0.49 ± 0.06 and 0.68 ± 0.05 respectively. After the surgery, there was a statistically significant decrease in the mean values of astigmatism: the main group – after 3 months to -1.8 ± 0.15 diopters (p <0.05), after 6 months – by another 1.7 ± 0.20 diopters (p <0.05); the control group – after 3 months to -2.43 ± 0.17 diopters (p <0.05), after 6 months – by another 2.42 ± 0.17 diopters. Conclusion. The proposed optimized ISKP technique with the use of a digital marking device provides precise positioning of segments during the surgical treatment of keratoconus and allows to obtain higher acuity of vision and best corrected visual acuity, as well as to correct corneal astigmatism more efficiently than using standard technique. Key words: surgical treatment of keratoconus, femtolaser intrastromal implantation of corneal segments, digital marking device.","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131220724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-19DOI: 10.25276/0235-4160-2022-4-18-24
E.V. Kalinina, A. Grinev, M. B. Sviridova, A. M. Danilov, A.A. Grinev, V. Bachurikhin
Purpose. To evaluate results of an experimental and clinical study of new hydrophilic intraocular lens implantation for aphakia correction in cataract surgery. Material and methods. Experimental part was performed using electron scanning microscopy. Surface and angle of the optical edge of the IOL «Aquamarine» were studied. Clinical part included analysis of 500 implantations of Aquamarine IOL with a followup period up to 1 month (group 1), 200 of those implantations had a follow-up period up to one year (group 2). Results. Surface of the IOL had no superficial defects. Optical edge had a rectangular angle over 360°. Area of deviation from the ideal rectangular shape varied between 49.06–175.50 um²at a radius of 40 um and 75.29–264.70 um² at a radius of 60 um. Implantation of Aquamarine hydrophilic lenses made it possible to obtain a high visual acuity of 0.5 or more in 89.6% of cases. Conclusion. A clinical study revealed high uveal and capsule biocompatibility of the Aquamarine IOL, and stable refractive data in the follow up period up to 1 year. Key word:: electron scanning microscopy, IOL «Aquamarine», clinical research, cataract surgery.
{"title":"Results of an experimental and clinical study of new hydrophilic intraocular lens implantation for aphakia correction in cataract surgery","authors":"E.V. Kalinina, A. Grinev, M. B. Sviridova, A. M. Danilov, A.A. Grinev, V. Bachurikhin","doi":"10.25276/0235-4160-2022-4-18-24","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-4-18-24","url":null,"abstract":"Purpose. To evaluate results of an experimental and clinical study of new hydrophilic intraocular lens implantation for aphakia correction in cataract surgery. Material and methods. Experimental part was performed using electron scanning microscopy. Surface and angle of the optical edge of the IOL «Aquamarine» were studied. Clinical part included analysis of 500 implantations of Aquamarine IOL with a followup period up to 1 month (group 1), 200 of those implantations had a follow-up period up to one year (group 2). Results. Surface of the IOL had no superficial defects. Optical edge had a rectangular angle over 360°. Area of deviation from the ideal rectangular shape varied between 49.06–175.50 um²at a radius of 40 um and 75.29–264.70 um² at a radius of 60 um. Implantation of Aquamarine hydrophilic lenses made it possible to obtain a high visual acuity of 0.5 or more in 89.6% of cases. Conclusion. A clinical study revealed high uveal and capsule biocompatibility of the Aquamarine IOL, and stable refractive data in the follow up period up to 1 year. Key word:: electron scanning microscopy, IOL «Aquamarine», clinical research, cataract surgery.","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"17 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114030853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-17DOI: 10.25276/0235-4160-2022-3-75-81
D. A. Latigan, K. L. Latigan, S. Sakhnov, E. V. Bykova, A. V. Usov
Purpose. To present data on pathogenesis, clinical manifestations, diagnostic methods and treatment of uveal effusion syndrome. Material and methods. To perform the review, literature sources were searched through the Pubmed, Scopus and eLibrary databases up to and including 2020, using the keywords: «uveal effusion», «ciliochoroidal detachment», «choroidal effusion», «serous retinal detachment», «nanophtalmos», «uveal effusion syndrome». A total of 46 articles related to the topic of the review were selected. The beginning of publications on this theme started at 1963. Results. Analysis of publications testifies that today difficulties in diagnosing and determining therapeutic tactics for uveal effusion syndrome are due to the vastness of the differential diagnostic search, a variety of clinically similar diseases and the lack of consensus on the pathogenesis of this condition. Conclusion. Uveal effusion syndrome is a diagnosis of exclusion which can be taken only when other reasons of ciliochoroidal detachment, such as rhematogenous retinal detachment, inflammatory processes, neoplastic processes, systemic diseases, trauma, previous ophthalmic surgery, are excluded. Correct diagnosis and determination the type of uveal effusion syndrome can save patients from unnecessary surgical procedures, such as vitrectomy or even enucleation. Key words: uveal effusion syndrome, pathogenesis, classification, treatment
{"title":"The uveal effusion syndrome","authors":"D. A. Latigan, K. L. Latigan, S. Sakhnov, E. V. Bykova, A. V. Usov","doi":"10.25276/0235-4160-2022-3-75-81","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-3-75-81","url":null,"abstract":"Purpose. To present data on pathogenesis, clinical manifestations, diagnostic methods and treatment of uveal effusion syndrome. Material and methods. To perform the review, literature sources were searched through the Pubmed, Scopus and eLibrary databases up to and including 2020, using the keywords: «uveal effusion», «ciliochoroidal detachment», «choroidal effusion», «serous retinal detachment», «nanophtalmos», «uveal effusion syndrome». A total of 46 articles related to the topic of the review were selected. The beginning of publications on this theme started at 1963. Results. Analysis of publications testifies that today difficulties in diagnosing and determining therapeutic tactics for uveal effusion syndrome are due to the vastness of the differential diagnostic search, a variety of clinically similar diseases and the lack of consensus on the pathogenesis of this condition. Conclusion. Uveal effusion syndrome is a diagnosis of exclusion which can be taken only when other reasons of ciliochoroidal detachment, such as rhematogenous retinal detachment, inflammatory processes, neoplastic processes, systemic diseases, trauma, previous ophthalmic surgery, are excluded. Correct diagnosis and determination the type of uveal effusion syndrome can save patients from unnecessary surgical procedures, such as vitrectomy or even enucleation. Key words: uveal effusion syndrome, pathogenesis, classification, treatment","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126430050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-17DOI: 10.25276/0235-4160-2022-3-51-56
G. Gladysheva, I. Plisov, N. Antsiferova, V. B. Pushchina, D. R. Mamulat, K. A. Belousova, M. A. Sharokhin
Purpose. To determine the most common ocular causes and types of anomalous head position and give details of their functional features. Material and methods. The research included 105 patients with an anomalous head position. Depending on the oculomotor pathology, patients were divided into 6 groups. 1st group – 10 patients with Brown syndrome, 2nd group – 20 patients with Duane syndrome of types 1 and 2, 3rd group – 30 patients with nystagmus, 4th group – 30 patients with n. abducensparalysis, 5th group – 15 patients with n. trochlearisparalysis, and control 6th group – 20 patients with one of the above pathology, but without anomalous head posture (AHP). Results. Out of 105 patients with AHP, 83.8% had both fusion and stereopsis. There was no statistical difference in the rate of fusion or stereopsis among the different AHP types (p=0.580). The control group showed accurately low scores of stereopsis and fusion loss (5.3%) (p=0.001). The overall incidence of amblyopia in all groups of patients with AHP (with Brown, Duyane syndrome, with nystagmus by 3.7 times, with paralysis and paresis of n. abducensand n. trochlearis) is statistically significantly lower (p<0.001) than in the control group. Conclusion. The most common ocular causes of anomalous head position are nystagmus and paralysis of the abducens nerve, as well as Duane syndrome and paralysis of the trochlear nerve. Head rotation is most commonly associated with congenital nystagmus, Duane syndrome, and n. abducens paralysis and paresis. Head tilt or various combinations of head tilt with a raised chin is most characteristic of n. trochlearis paralysis and paresis and Brown syndrome. AHP formation is a «protective» mechanism in terms of developing amblyopia and loss of binocular single vision. Key words: abnormal head position, binocular vision, stereopsis, amblyopia.
{"title":"Abnormal head posture a new paradigm","authors":"G. Gladysheva, I. Plisov, N. Antsiferova, V. B. Pushchina, D. R. Mamulat, K. A. Belousova, M. A. Sharokhin","doi":"10.25276/0235-4160-2022-3-51-56","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-3-51-56","url":null,"abstract":"Purpose. To determine the most common ocular causes and types of anomalous head position and give details of their functional features. Material and methods. The research included 105 patients with an anomalous head position. Depending on the oculomotor pathology, patients were divided into 6 groups. 1st group – 10 patients with Brown syndrome, 2nd group – 20 patients with Duane syndrome of types 1 and 2, 3rd group – 30 patients with nystagmus, 4th group – 30 patients with n. abducensparalysis, 5th group – 15 patients with n. trochlearisparalysis, and control 6th group – 20 patients with one of the above pathology, but without anomalous head posture (AHP). Results. Out of 105 patients with AHP, 83.8% had both fusion and stereopsis. There was no statistical difference in the rate of fusion or stereopsis among the different AHP types (p=0.580). The control group showed accurately low scores of stereopsis and fusion loss (5.3%) (p=0.001). The overall incidence of amblyopia in all groups of patients with AHP (with Brown, Duyane syndrome, with nystagmus by 3.7 times, with paralysis and paresis of n. abducensand n. trochlearis) is statistically significantly lower (p<0.001) than in the control group. Conclusion. The most common ocular causes of anomalous head position are nystagmus and paralysis of the abducens nerve, as well as Duane syndrome and paralysis of the trochlear nerve. Head rotation is most commonly associated with congenital nystagmus, Duane syndrome, and n. abducens paralysis and paresis. Head tilt or various combinations of head tilt with a raised chin is most characteristic of n. trochlearis paralysis and paresis and Brown syndrome. AHP formation is a «protective» mechanism in terms of developing amblyopia and loss of binocular single vision. Key words: abnormal head position, binocular vision, stereopsis, amblyopia.","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131142719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-17DOI: 10.25276/0235-4160-2022-3-68-74
Y. Pashentsev
Purpose. To compare various approaches to statistical analysis of fellow eyes and to describe correct analysis using nonparametric tests with R software. Material and methods. Various approaches to statistical analysis of fellow eyes are analyzed. Three general strategies are stated: 1) inclusion of both eyes in the same group using standard methods of statistical analysis; 2) inclusion in the same group only one eye of each subject using standard statistical methods; 3) inclusion of the both eyes in the same group using advanced statistical methods accounting correlation between fellow eyes. Results. The first approach leads to a significant underestimation of p-values when comparing groups and increases the risk of rejecting the correct null hypothesis. The second approach does not allow taking into account all available data and decreases the statistical power of a study. The third approach uses all available data and allows making valid inferences. Conclusion. Unreasonable use of standard statistical approaches for analyses quantitative data of fellow eyes leads to a significant distortion of p-values, does not allow taking into account all the material. Best practices for such situations are advanced statistical techniques accounting correlations between fellow eyes, such as the RGL and DS methods of package clusrank for R language. Key words: clustered data, fellow eyes, Mann–Whitney U test, Wilcoxon test, R software environment, clusrank package
{"title":"Features of statistical analysis of quantitative data obtained from fellow eyes, nonparametric tests","authors":"Y. Pashentsev","doi":"10.25276/0235-4160-2022-3-68-74","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-3-68-74","url":null,"abstract":"Purpose. To compare various approaches to statistical analysis of fellow eyes and to describe correct analysis using nonparametric tests with R software. Material and methods. Various approaches to statistical analysis of fellow eyes are analyzed. Three general strategies are stated: 1) inclusion of both eyes in the same group using standard methods of statistical analysis; 2) inclusion in the same group only one eye of each subject using standard statistical methods; 3) inclusion of the both eyes in the same group using advanced statistical methods accounting correlation between fellow eyes. Results. The first approach leads to a significant underestimation of p-values when comparing groups and increases the risk of rejecting the correct null hypothesis. The second approach does not allow taking into account all available data and decreases the statistical power of a study. The third approach uses all available data and allows making valid inferences. Conclusion. Unreasonable use of standard statistical approaches for analyses quantitative data of fellow eyes leads to a significant distortion of p-values, does not allow taking into account all the material. Best practices for such situations are advanced statistical techniques accounting correlations between fellow eyes, such as the RGL and DS methods of package clusrank for R language. Key words: clustered data, fellow eyes, Mann–Whitney U test, Wilcoxon test, R software environment, clusrank package","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115923641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-17DOI: 10.25276/0235-4160-2022-3-34-40
A. N. Steblyuk, V. Gunter, S. N. Sahnov, P. Khloponin, Е.V. Bykova, Z.G. Litvinova
Purpose. Assessment of the functional state of eye adnexal apparatus and eyeball after cryodestruction of the dermal eyelid nevus using modern cryosurgical equipment. Material and methods. The clinical studies were conducted in 17 patients (17 eyes) with nevus in the eyelid intermarginal space, with conducting nevus cryodestruction using an autonomous cryoapplicator of porous-permeable titanium nickelide. Results. The new generation cryogenic systems are remarkable for new properties compared to the known cryogenic apparatuses. They can significantly improve the surgery quality in cryotherapy due to a more distinct localization of cryotherapy and a high rate of heat removal from the altered tissue surface without damaging the surrounding tissues. Depending on the size of the pathological formation, exposure duration, the frequency of application repetitions per session, the nevus regression occurred within 1.5–2.0 months with preserving the integrity of the eyelid intermarginal space and the eye functional condition. Conclusion. The analysis of the data obtained evidences for a high clinical and cosmetic cryosurgery effectiveness for the eyelid nevus intermarginal space using an autonomous cryoapplicator of porous-permeable titanium nickelide. Key words: cryosurgery, dermal eyelid nevus, cryoapplicator of titanium nickelide.
{"title":"Сryosurgery possibilities for nevus in intermarginal eyelid space","authors":"A. N. Steblyuk, V. Gunter, S. N. Sahnov, P. Khloponin, Е.V. Bykova, Z.G. Litvinova","doi":"10.25276/0235-4160-2022-3-34-40","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-3-34-40","url":null,"abstract":"Purpose. Assessment of the functional state of eye adnexal apparatus and eyeball after cryodestruction of the dermal eyelid nevus using modern cryosurgical equipment. Material and methods. The clinical studies were conducted in 17 patients (17 eyes) with nevus in the eyelid intermarginal space, with conducting nevus cryodestruction using an autonomous cryoapplicator of porous-permeable titanium nickelide. Results. The new generation cryogenic systems are remarkable for new properties compared to the known cryogenic apparatuses. They can significantly improve the surgery quality in cryotherapy due to a more distinct localization of cryotherapy and a high rate of heat removal from the altered tissue surface without damaging the surrounding tissues. Depending on the size of the pathological formation, exposure duration, the frequency of application repetitions per session, the nevus regression occurred within 1.5–2.0 months with preserving the integrity of the eyelid intermarginal space and the eye functional condition. Conclusion. The analysis of the data obtained evidences for a high clinical and cosmetic cryosurgery effectiveness for the eyelid nevus intermarginal space using an autonomous cryoapplicator of porous-permeable titanium nickelide. Key words: cryosurgery, dermal eyelid nevus, cryoapplicator of titanium nickelide.","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124429248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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