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Refractive results of cataract surgery with posterior capsulorhexis and optic capture 白内障后囊摘除术及视神经捕获的屈光效果
Pub Date : 2022-10-17 DOI: 10.25276/0235-4160-2022-3-13-19
E. V. Egorova, A. Biryukova, V. V. Dulidova, M. A. Talalaev
Purpose. To compare refractive results in the following groups: after standard cataract surgery (1), standard cataract surgery supplemented with primary posterior capsulorhexis (2) and supplemented with a posterior capture of the IOL optics (3). Material and methods. This study included 32 patients (40 eyes) aged 52 to 68 years after uncomplicated phacoemulsification of age-related cataract with implantation of several models of monolithic flexible hydrophobic IOLs: Tecnis (J&J), enVista (B&L), RPR-2 (Reper-NN). The axial length of the eyes varied from 22.2 to 25,25 mm. The exclusion criteria were pseudoexfoliation syndrome and concomitant ophthalmopathology. Results. There were no intra- and postoperative complications in all studied groups. OCT monitoring showed the intactness of the anterior hyaloid in the second and third groups, the centered IOL position and the location of the capsular sheets according to the applied technology. The obtained refractive results were compared with the target refraction when calculating the IOL. The emmetropia was planned in all cases. However, because the strength of the lenses has discrete values with a step of 0.5 diopters, the closest value with a shift towards myopia was chosen. No statistically significant differences were found in the first and second compared groups when evaluating the refractive Results. However, the postoperative parameters were statistically significantly different in the third group with posterior optic capture. In this group a hyperopic shift of about 0,5 diopters was always observed. Conclusion. Primary posterior capsulorhexis with posterior optics capture provides a stable centered IOL position. The axial displacement of the IOL and the hypermetropic shift of the refractive results should be considered when planning posterior optical capture. Key words: posterior capsulorhexis, posterior optic capture, optic buttonholing
目的。比较以下两组患者的屈光结果:标准白内障手术后(1),标准白内障手术后合并原发性后撕囊术(2),以及后路人工晶状体捕获术(3)。材料和方法本研究纳入32例(40只眼)年龄52 ~ 68岁的老年性白内障无并发症超声乳化术患者,并植入了几种型号的单片柔性疏水人工晶体:Tecnis (J&J), enVista (B&L), RPR-2 (Reper-NN)。眼轴长为22.2 ~ 25,25 mm。排除标准为假性脱落综合征和伴随的眼部病理。结果。所有研究组均无术中及术后并发症。OCT监测显示第二组和第三组前晶状体完整,人工晶状体中心位置和囊片位置。计算人工晶体时,将所得屈光结果与目标屈光进行比较。斜视在所有病例中都是有计划的。然而,由于透镜的强度具有0.5屈光度阶跃的离散值,因此选择了最接近近视眼的值。第1组和第2组屈光结果比较无统计学差异。而第三组术后参数差异有统计学意义。在这一组中,总是观察到约0.5屈光度的远视移位。结论。初级后撕囊与后光学捕获提供了稳定的中心位置的人工晶状体。人工晶状体的轴向位移和屈光结果的远视偏移应在规划后光捕获时予以考虑。关键词:后撕囊,后视点捕获,视点扣孔
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引用次数: 0
Intraocular correction of presbyopia after laser keratorefractive surgery 激光角膜屈光术后老花眼的眼内矫正
Pub Date : 2022-10-17 DOI: 10.25276/0235-4160-2022-3-98-104
A. Doga, E. V. Kechin, A. Golovin, A. N. Karimova, N. Tsikarishvili, A.N. Dzhaber
Purpose. To present the results of research on modern aspects of intraocular correction of presbyopia after laser keratorefractive surgery. Material and methods. A literature search was performed to identify studies on databases eLibrary, PubMed and Scopus, using the keywords «calculation of multifocal lenses», «multifocal IOLs after refractive surgery», «correction of presbyopia after refractive surgery» (in the eLibrary database), «multifocal IOL» and «multifocal lenses calculation» (in the PubMed and Scopus databases). Thirty related articles were identified. In addition, seven clinical studies in which different groups of patients with a history of refractive surgery underwent correction of presbyopia with multifocal intraocular lenses (IOL) were identified. Results. In this article, there are examples of recent research of information about the intricacies of calculating refractive power of multifocal lenses after refractive surgery. Every year the number of people with a history of laser vision correction is growing, which means that for surgeons arises question about correct calculation of keratometric parameters. To date, the calculation of the value of the optical power of an implantable multifocal IOL after laser refractive surgery is complex and individual for each patient. Most people in this category are still not ready to wear glasses. Recent studies confirm the success of calculating implantable multifocal IOL, and ways to minimize inaccuracies in hitting the refraction of the target lie both in the approach to calculating the optical power of an implanted multifocal lens, and in choosing the optimal method for assessing artificially modified cornea keratometry. Conclusion. The results of clinical studies presented in the review allow us to conclude that the results of calculating the optical power of implanted multifocal IOLs are quite successful and, in turn, clinical and functional results in patients with a history of laser refractive surgery. However, further research is required. Key words: presbyopia correction, multifocal IOL, IOL calculation formulas, laser correction, LASIK, FemtoLASIK, SMILE.
目的。介绍激光角膜屈光术后老花眼内矫正的现代研究成果。材料和方法。使用关键词“计算多焦点晶状体”、“屈光手术后多焦点IOL”、“屈光手术后老花眼矫正”(在图书馆数据库中)、“多焦点IOL”和“多焦点晶状体计算”(在PubMed和Scopus数据库中),对数据库eLibrary、PubMed和Scopus进行文献检索,以确定数据库中的研究。确定了30篇相关文章。此外,我们还发现了7项不同组有屈光手术史的患者采用多焦人工晶体(IOL)矫正老花眼的临床研究。结果。在这篇文章中,有关于屈光手术后计算多焦透镜屈光功率的复杂性的最新研究的例子。每年有激光视力矫正史的人数都在增长,这意味着对于外科医生来说,角膜测量参数的正确计算出现了问题。迄今为止,计算激光屈光手术后植入式多焦点IOL的光功率值是复杂的,每个患者都有自己的特点。这一类别的大多数人还没有准备好戴眼镜。最近的研究证实了植入式多焦人工晶状体的计算是成功的,而如何在计算植入式多焦晶状体的光功率的方法和选择评估人工改良角膜度数的最佳方法中最大限度地减少达到目标折射的不准确性。结论。本综述中提出的临床研究结果使我们得出结论,计算植入的多焦iol的光功率的结果是相当成功的,反过来,有激光屈光手术史的患者的临床和功能结果也是如此。然而,还需要进一步的研究。关键词:老花矫正,多焦点人工晶状体,人工晶状体计算公式,激光矫正,LASIK, FemtoLASIK, SMILE
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引用次数: 0
Effectiveness and safety of Blefarovit cosmetic product usage in patients with chronic blepharoconjunctivitis and «dry eye» syndrome, combined with an active demodicosis component Blefarovit化妆品在慢性眼睑结膜炎和“干眼”综合征患者中使用的有效性和安全性,并伴有活动性蠕虫病成分
Pub Date : 2022-10-17 DOI: 10.25276/0235-4160-2022-3-41-49
D. Maychuk, А.О. Loshkareva
Purpose. Comparative analysis of the efficacy and safety of Blefarovit product in the complex therapy of chronical blepharoconjunctivitis and «dry eye» syndrome with a pronounced demodicosis component in patients, previously received standard treatment with or without short-term positive effect. Material and methods. The present study included 60 patients (120 eyes) with chronical blepharoconjunctivitis, «dry eye» syndrome and demodicosis component. The patients, involved in the study had pronounced thickening of the eyelid margin, scabs and «clutches» in the eyelashes, meibomeitis, hyperemia, follicular reaction of the tarsal and bulbar conjunctiva. This study was devoted to finding a new approach for the demodecosis component therapy, using staged eyelid hygiene technology with the multicomponent product Blefarovit. The purpose of this study was to estimate efficacy and safety in isolated Blefarovit usage (1st stage of therapy) and Blefarovit in the combination with anti-inflammatory and artificial tears therapy (2nd stage of therapy). Results. The results of the study were increasing of the TBUT test and decreasing the ofDemodex Folliculorumnumber. Conclusion. The usage of Blefarovit product made possible to show significant decreasing in the severity of the demodectic component without increasing the toxicoallergic background. Key words: blepharitis, conjunctivitis, «dry eye» syndrome, meibomian gland dysfunction, eyelid hygiene, demodex
目的。比较分析Blefarovit产品在慢性眼睑结膜炎和“干眼”综合征的综合治疗中的疗效和安全性,这些患者有明显的demodemoosis成分,之前接受过标准治疗,有或没有短期的积极作用。材料和方法。本研究包括60例(120只眼睛)慢性眼睑结膜炎、“干眼”综合征和蠕虫病成分。参与研究的患者有明显的眼睑边缘增厚,睫毛结痂和“抓”,睑板炎,充血,睑窝和球结膜的滤泡反应。本研究旨在寻找一种新的方法,采用分阶段眼睑卫生技术和多成分产品Blefarovit治疗龋病。本研究的目的是评估单独使用Blefarovit(第一阶段治疗)和Blefarovit联合抗炎和人工泪液治疗(第二阶段治疗)的疗效和安全性。结果。结果表明:TBUT升高,毛囊蠕形螨数量降低。结论。使用Blefarovit产品可以在不增加毒性过敏背景的情况下显着降低流行成分的严重程度。关键词:眼睑炎,结膜炎,“干眼”综合征,睑板腺功能障碍,眼睑卫生,蠕形螨
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引用次数: 1
Crucial fluorescent angiographic features of favorable and unfavorable course of active retinopathy of prematurity 早产儿活动性视网膜病变有利和不利病程的关键荧光血管造影特征
Pub Date : 2022-10-17 DOI: 10.25276/0235-4160-2022-3-57-67
I. G. Trifanenkova, A. V. Tereshchenko
Purpose. To determine the crucial fluorescence-angiographic features of favorable and unfavorable types of active retinopathy of prematurity and evaluate their prognostic informational value. Material and methods. Fundus fluorescence angiography (FFA) was performed by 180 premature infants (180 eyes). The children had 1st–3rd stage of active ROP. The age of gestation of the children was 24–34 weeks. A birth weight of the children was 560–2150 g. By the time of the study the age of the children was 3–14 weeks. This age corresponded to 30–38 weeks of postconceptual age (PCA). The stage and type of the pathological process was determined by using a comprehensive ophthalmological examination, which included reverse ophthalmoscopy, digital retinoscopy and morphometry. Children were admitted to FFA procedure in a stable somatic state, without pathology of renal and hepatic metabolism, after setting a test to determine the sensitivity to the drug. The evaluation of the prognostic information content of the revealed features of FFA in relation to the type of disease course was performed. Statistical processing of the research results was carried out by using the Statistica 13.3 program (Tibco Software Inc., USA). Results. During of the study, pathological fluorescence-angiographic features were identified and studied. These features were conditionally divided into 3 groups depending on the location on the fundus: near the border with the avascular retina, in the avascular retina, in the vascularized retina. It has been shown that the unfavorable course of the 1st–3rd stage of active ROP is distinguished by a much wider variety of fluorescence-angiographic phenomena and their more pronounced intensity (frequency of occurrence) in comparison with the favorable course of active ROP. On the basis of a comprehensive statistical analysis, the most informative fluorescence-angiographic features for the prognosis of the type of active ROP were determined: increased vascular tortuosity near the border with the avascular retina, zones of capillary nonperfusion in the vascularized retina, multiple foci of local neovascularization in the vascularized retina. Conclusion. Clinical use of a fluorescence angiographic study of the fundus of patients with ROP with the determination of crucial prognostic features of favorable and unfavorable types in the early stages of the disease will contribute to early treatment of this severe retinal pathology in premature infants and consequently, its favorable outcome. Key words: fluorescence angiography, retinopathy of prematurity, prognosis
目的。确定有利和不利类型的早产儿活动性视网膜病变的关键荧光血管造影特征,并评估其预后信息价值。材料和方法。对180例早产儿(180眼)进行眼底荧光血管造影(FFA)检查。患儿ROP活动期为1 ~ 3期。胎龄24-34周。新生儿出生体重560-2150克。研究开始时,这些孩子的年龄为3-14周。这个年龄对应于30-38周的产后年龄(PCA)。通过眼科综合检查,包括反视镜、数字视网膜镜和形态测量,确定病理过程的阶段和类型。在确定对药物的敏感性后,儿童在稳定的躯体状态下接受FFA手术,没有肾脏和肝脏代谢病理。评估FFA所显示的特征与病程类型之间的预后信息含量。使用Statistica 13.3软件(Tibco Software Inc., USA)对研究结果进行统计处理。结果。在研究期间,病理荧光血管造影特征被确定和研究。这些特征根据在眼底的位置有条件地分为3组:靠近无血管视网膜边界、在无血管视网膜内、在血管化视网膜内。研究表明,与活动性ROP的有利病程相比,活动性ROP的第1 - 3期的不利病程具有更广泛的荧光血管造影现象和更明显的强度(发生频率)。在综合统计分析的基础上,确定了活动性ROP类型预后的最具信息量的荧光血管造影特征:无血管视网膜边界附近血管扭曲增加,血管化视网膜内毛细血管非灌注区,血管化视网膜内局部新生血管多发灶。结论。临床应用荧光血管造影研究ROP患者眼底,确定疾病早期有利和不利类型的关键预后特征,将有助于早产儿这种严重视网膜病理的早期治疗,从而获得良好的结果。关键词:荧光血管造影,早产儿视网膜病变,预后
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引用次数: 0
Experience with the use of glucocorticosteroid implants in patients with macular edema associated with sarcoidosis. 糖皮质激素植入治疗与结节病相关的黄斑水肿的经验。
Pub Date : 2022-10-17 DOI: 10.25276/0235-4160-2022-3-28-33
V. A. Pavlov, E. Kryukov, D. Davydov, A. Zaytsev, V. E. Kurnosov, A. Kapatsina
Purpose. To evaluate the results of treatment of patients with sarcoidosis with chronic non-infectious uveitis complicated by macular edema by intravitreal injection of a glucocorticosteroid implant with previously used methods. Material and methods. The study performed a comparative analysis of data from patients with cystic macular edema against the background of chronic non-infectious uveitis associated with sarcoidosis, with corrected visual acuity of more than 0.05 (according to the Golovin-Sivtsev table). Group 1 (prospective analysis) included the results of treatment of patients with sarcoidosis with corticosteroid implants (4 eyes, 4 patients). In the 2nd group (retrospective analysis of the medical history), patients underwent peribulbar administration of betamethasone (9 eyes, 7 patients). The parameters were analyzed after 2.0±0.5, 4.0±0.5 and 6.0±0.5 months with assessment of maximally corrected visual acuity (BCVA), OCT, color photography, and IOP control. The risk of recurrence of macular edema when comparing groups was assessed over a 6-month follow-up period. Results. During the observed period in both groups, no complications were detected in any case. According to visometry and OCT, the best functional results were obtained in group 1. Average visual acuity after 6 months. was 0.7±0.1, the thickness of the retina in the central zone was 331±15µm. Conclusion. According to the results of the study, it was found that intravitreal injection of dexamethasone implant in its effectiveness surpasses the previously used peribulbar injections of betamethasone in terms of the quality of restoration of visual functions, the effectiveness of reducing macular edema and the duration of remission of the chronic inflammatory process. Key words: sarcoidosis, chronic uveitis, macular edema, dexamethasone implant, surgical treatment
目的。目的评价玻璃体内注射糖皮质激素治疗结节病合并慢性非感染性葡萄膜炎合并黄斑水肿的疗效。材料和方法。该研究对伴有结节病的慢性非感染性葡萄膜炎的囊性黄斑水肿患者的数据进行了比较分析,这些患者的矫正视力大于0.05(根据Golovin-Sivtsev表)。第1组(前瞻性分析)包括糖皮质激素植入治疗结节病患者的结果(4眼,4例)。第二组(回顾性病史分析)患者行倍他米松球周治疗(9眼,7例)。分别于2.0±0.5、4.0±0.5、6.0±0.5个月后进行最大矫正视力(BCVA)、OCT、彩色摄影、IOP控制等参数分析。在6个月的随访期间,对对照组黄斑水肿复发的风险进行评估。结果。两组患者观察期间均未发生并发症。通过粘度测定和OCT检查,1组的功能效果最好。6个月后的平均视力。为0.7±0.1,中心区视网膜厚度为331±15µm。结论。根据研究结果,我们发现玻璃体内注射地塞米松植入体在视觉功能的恢复质量、减轻黄斑水肿的有效性和慢性炎症过程的缓解时间方面,其有效性超过了以前使用的球周注射倍他米松。关键词:结节病,慢性葡萄膜炎,黄斑水肿,地塞米松植入,手术治疗
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引用次数: 0
Limbal stem cell deficiency diagnostics 角膜缘干细胞缺乏症诊断
Pub Date : 2022-10-17 DOI: 10.25276/0235-4160-2022-3-82-97
B. Malyugin, S. Borzenok, S. Kalinnikova, M. Gerasimov
Relevance. Limbal stem cell deficiency (LSCD) is a pathology that leads to substantial vision decrease, corneal neovascularization, corneal epithelial persistent erosions and have a negative impact on patient's the quality of life. It is known that the efficiency of corneal transplantation in LSCD patients is low and requires repeated interventions. One of the important problems is the lack of a clear diagnostic algorithm and a standardized set of diagnostic techniques for this condition. Purpose. Systematically analyze domestic and foreign literature on the currently existing methods for diagnosing LSCD. Material and methods. A systematic analysis of scientific publications from 1992 to 2021 was carried out. Its included domestic and foreign authors on the resources of PubMed, Medline, eLibrary, as well as dissertations and textbooks devoted to currently existing methods for diagnosing LSCD. Results. In addition to biomicroscopy, the main in vivomethods for diagnosing LSCD are staining of the ocular surface, impression cytology with the detection of specific cytokeratins, confocal microscopy, optical coherence tomography of the anterior segment (OST) and OST-angiography. Conclusion. Physician awareness and vigilance are required for the diagnosis of LSCD, especially in patients with conjunctivalization and corneal neovascularization. It is impossible to use only biomicroscopy and the patient's complaints, since LSCD is not always obvious. That is why diagnostics should include an integrated approach, including all available research methods, which are briefly described in Table No. 1 with their disadvantages and advantages. Key words: limbal stem cell deficiency, impression cytology, laser confocal scanning microscopy, goblet cells, cytokeratin, penetrating keratoplasty, cytokines
的相关性。角膜缘干细胞缺乏症(Limbal stem cell deficiency, LSCD)是一种导致视力明显下降、角膜新生血管形成、角膜上皮持续糜烂的病理,对患者的生活质量有负面影响。众所周知,LSCD患者角膜移植的效率很低,需要反复干预。其中一个重要的问题是缺乏明确的诊断算法和一套标准化的诊断技术。目的。系统分析了目前国内外关于LSCD诊断方法的文献。材料和方法。对1992年至2021年的科学出版物进行了系统分析。它包括国内外作者在PubMed, Medline, library的资源,以及致力于目前LSCD诊断方法的论文和教科书。结果。除生物显微镜外,诊断LSCD的主要活体方法是眼表染色、检测特定细胞角蛋白的印象细胞学、共聚焦显微镜、前段光学相干断层扫描(OST)和OST血管造影。结论。对于LSCD的诊断,特别是结膜炎和角膜新生血管的患者,需要医师的认识和警惕。由于LSCD并不总是很明显,因此仅使用生物显微镜和患者的主诉是不可能的。这就是为什么诊断应该包括一个综合的方法,包括所有可用的研究方法,表1简要描述了它们的缺点和优点。关键词:角膜缘干细胞缺乏症,印象细胞学,激光共聚焦扫描显微镜,杯状细胞,细胞角蛋白,穿透性角膜移植术,细胞因子
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引用次数: 0
Study psychoemotional status in patients planning keratorefractive surgery using SMILE procedure 探讨SMILE角膜屈光手术患者的心理情绪状况
Pub Date : 2022-10-17 DOI: 10.25276/0235-4160-2022-3-20-27
I. V. Dutchin, O. V. Kolenko, O.B. Dutchina, E. L. Sorokin, Y. Kutuzova
Purpose. To study frequency and degree of mental stress among patients with myopia planning to keratorefractive surgery using SMILE procedure. Material and methods. In-depth psychological study was carried out in 145 patients planning for keratorefractive surgery. The average age of the patients is 37 years. At the first stage, patients with an increased level of psychological anxiety were identified using the «Unfinished sentences» method. At the second stage, among the selected patients, we studied the degree of their mental stress using stress scale with the Psychological Stress Measure (PSM-25) questionnaire. Results. At the first stage, 42 patients (29%) were identified with increased level of psychological anxiety: 20 men and 22 women. Their average age was 35 years. At the second stage, it turned out that 9 patients had high level mental stress; in 13 – average and in 20 people – low (the latter are psychologically stable). During routine external examination and interview with ophthalmologist, patients with average and high-level mental stress indicator did not have any characteristic differences both from patients with low level mental stress indicator and from the rest of patients in general population. Conclusion. At conducting screening psychological test among the surveyed large population of patients with myopia planning to keratorefractive surgery, 29% patients with unstable psychoemotional status were identified. Among the selected patients with unstable psychoemotional status, 21.5% had a high level of mental stress; 31% have average level and 47.5% have low level. Key words: patient anxiety, preoperative stress, psychological stress diagnosis
目的。目的探讨拟行SMILE角膜屈光手术的近视患者精神压力的发生频率和程度。材料和方法。对145例拟行角膜屈光手术的患者进行了深入的心理研究。患者平均年龄37岁。在第一阶段,使用“未完成的句子”方法识别心理焦虑水平增加的患者。第二阶段,采用心理压力量表和心理压力量表(PSM-25)对入选患者的心理压力程度进行研究。结果。在第一阶段,42名患者(29%)被确定为心理焦虑水平增加:20名男性和22名女性。他们的平均年龄为35岁。在第二阶段,发现9例患者有高水平的精神压力;13人——平均水平,20人——低水平(后者心理稳定)。在常规外部检查和眼科医生访谈中,心理应激指标中高的患者与心理应激指标中低的患者以及与普通人群的其他患者没有任何特征差异。结论。在调查的大量拟行角膜屈光手术的近视患者中进行筛查心理测试,发现29%的患者心理情绪状态不稳定。在心理情绪状态不稳定的患者中,21.5%的患者精神压力水平较高;31%为平均水平,47.5%为低水平。关键词:患者焦虑,术前应激,心理应激诊断
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引用次数: 0
Glial cell line-derived neurotrophic factor in patients with age-related cataract 胶质细胞系源性神经营养因子在老年性白内障患者中的作用
Pub Date : 2022-10-17 DOI: 10.25276/0235-4160-2022-3-8-12
A. Shpak, A. Guekht, T. Druzhkova, A. Troshina, N. Gulyaeva
Purpose. To study the content of glial cell line-derived neurotrophic factor (GDNF) in the aqueous humor (AH), lacrimal fluid (LF), and blood serum (BS) in patients with age-related cataract. Material and methods. The content of GDNF in the LF, AH and BS was studied in 47 patients (47 eyes) with age-related cataract. Collection of stimulated LF was performed with a pipette on the day preceding surgery; the AH and BS were sampled during the phacoemulsification of a cataract. The concentration of GDNF was measured using an enzyme immunoassay. Results. The concentration of GDNF in the AH was 88.9±46.9 (2.0–212.5) pg/ml, in the BS – 201.1±44.6 (103.2–287.2) pg/ml, in the LF – 343.6±133.7 (172.8– 683.0) pg/ml. The levels of GDNF in the studied biological fluids did not show any significant correlations with each other. Conclusion. In patients with age-related cataract, the level of GDNF in the AH was relatively low: the concentration of GDNF in the AH was more than 2 times lower than in the BS and almost 4 times lower than in the LF. No significant correlations were found between the concentrations of GDNF in LF, AH and BS. Key words: glial cell line-derived neurotrophic factor, lacrimal fluid, aqueous humor, blood serum, age-related cataract
目的。目的:探讨老年性白内障患者房水(AH)、泪液(LF)和血清(BS)中神经胶质细胞系源性神经营养因子(GDNF)的含量。材料和方法。本文对47例(47眼)老年性白内障患者LF、AH和BS中GDNF的含量进行了研究。在手术前一天用移液管收集受刺激的LF;在白内障超声乳化术中采集超声心动图和超声心动图。采用酶免疫分析法测定GDNF浓度。结果。在AH中GDNF浓度为88.9±46.9 (2.0 ~ 212.5)pg/ml,在BS中为- 201.1±44.6 (103.2 ~ 287.2)pg/ml,在LF中为- 343.6±133.7 (172.8 ~ 683.0)pg/ml。研究的生物体液中GDNF的水平没有显示出任何显著的相关性。结论。在年龄相关性白内障患者中,AH中GDNF水平相对较低:AH中GDNF浓度比BS低2倍以上,比LF低近4倍。LF、AH和BS中GDNF浓度无显著相关性。关键词:神经胶质细胞系源性神经营养因子,泪液,房水,血清,老年性白内障
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引用次数: 1
Comparative analysis of the effectiveness of surgical treatment of macular hole with and without postoperative gas tamponade of the vitreal cavity 玻璃体腔术后气体填塞与不填塞黄斑裂孔手术治疗效果的比较分析
Pub Date : 2022-06-17 DOI: 10.25276/0235-4160-2022-2-6-14
A. Y. Kleymenov, V. Kazaykin, M. A. Lipina
Fyodorov Eye Microsurgery Federal State Institution, Ekaterinburg Branch, Ekaterinburg, Russian Federation
俄罗斯联邦叶卡捷琳堡,费奥多罗夫眼科显微外科联邦国立研究所叶卡捷琳堡分院
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引用次数: 0
Ophthalmic products with extracellular matrix components. Their effectiveness in the process of corneal repair in neurotrophic, herpetic, recurrent keratitis and erosions 含细胞外基质成分的眼科产品。它们在神经营养性、疱疹性、复发性角膜炎和糜烂性角膜修复过程中的有效性
Pub Date : 2022-06-17 DOI: 10.25276/0235-4160-2022-2-91-100
D. Maychuk, A. A. Tarkhanova, I. Pronkin, Д.Ю. Майчук, А.А. Тарханова, И.А. Пронкин
Introduction. One of the topical issues of modern ophthalmology is the widespread prevalence of corneal blindness among the working-age population. The cause of this condition in most cases are infectious and inflammatory diseases of the anterior segment of the eye, the outcome of which is a violation of the architectonics of the extracellular matrix (ECM) of the cornea, clinically manifested by edema of the stroma, its fibrosis. Purpose. Comparative analysis of the effectiveness of existing ophthalmic agents based on biomimetics of ECM to stimulate the processes of reparative regeneration in neurotrophic, herpetic, recurrent keratitis and corneal erosions. Material and methods. Our literature review has shown the great importance of the components in maintaining corneal homeostasis, its transparency, strength, shape stability, as well as differentiation, proliferation, migration and growth of cellular structures of the ECM, and therefore the need to maintain its physiological architectonics in the treatment of infectious and inflammatory pathology. Results. The range of ophthalmic medicines and medical devices based on biomimetics of ECM is quite diverse. The active substances of such ophthalmic agents are the main components of the ECM, namely, glycosaminoglycans (GAG), glycoproteins, collagen, hyaluronic acid, heparin. Conclusion. Among the many biomimetics, we can single out the multicomponent hydrogel composition «Corneal Epithelium gel Protector (CEGP) SPHERO ® oko (JSC «BIOMIR Service», Russia), designed to restore the corneal epithelium, which includes both the main components of ECM and other biologically active substances, including peptides, amino acids, uronic acids, monosaccharides, growth factors, etc. The multicomponent composition of SPHERO ® oko provides the microenvironment necessary for the cells of the eye tissues, contributing to the processes of their proliferation and differentiation and, as a final result, to the acceleration of reparative regeneration of tissues damaged as a result of injury or infectious-inflammatory process. And also SPHERO ® oko demonstrates anti-inflammatory, decongestant, tear-substituting action, contributes to reducing neovascularization. Key words: SPHERO ® oko, extracellular matrix, keratitis, erosion, herpes, dry eye disease, cornea
介绍。角膜失明在劳动年龄人群中的普遍流行是现代眼科学的热门问题之一。在大多数情况下,这种情况的原因是眼睛前段的感染性和炎症性疾病,其结果是角膜细胞外基质(ECM)结构的破坏,临床表现为基质水肿和纤维化。目的。基于仿生ECM的现有眼科药物刺激神经营养性、疱疹性、复发性角膜炎和角膜糜烂修复性再生过程的效果比较分析材料和方法。我们的文献综述表明,这些成分在维持角膜内稳态、透明度、强度、形状稳定性以及ECM细胞结构的分化、增殖、迁移和生长方面非常重要,因此在治疗感染和炎症病理时需要维持其生理结构。结果。基于ECM仿生学的眼科药物和医疗器械的范围非常多样化。这类眼药的活性物质是ECM的主要成分,即糖胺聚糖(GAG)、糖蛋白、胶原蛋白、透明质酸、肝素。结论。在众多仿生学产品中,我们可以挑选出多组分水凝胶组合物«角膜上皮凝胶保护剂(CEGP) SPHERO®oko (JSC«BIOMIR Service»,俄罗斯),旨在恢复角膜上皮,其中包括ECM的主要成分和其他生物活性物质,包括肽,氨基酸,糖酸,单糖,生长因子等。SPHERO®oko的多组分成分为眼组织细胞提供了必要的微环境,促进了它们的增殖和分化过程,并最终加速了因损伤或感染炎症过程而受损的组织的修复再生。此外,SPHERO®oko具有抗炎、减充血、泪液替代作用,有助于减少新生血管。关键词:SPHERO®oko,细胞外基质,角膜炎,糜烂,疱疹,干眼病,角膜
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Fyodorov journal of ophthalmic surgery
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