Pub Date : 2022-10-01DOI: 10.14427/jipai.2022.4.42
S. Yudina, I. Ivanova, T. Rusanova, I. Makeeva, M. Korshikova
{"title":"Antimicrobial peptides and nitric oxide as prognostic criteria for bronchial asthma","authors":"S. Yudina, I. Ivanova, T. Rusanova, I. Makeeva, M. Korshikova","doi":"10.14427/jipai.2022.4.42","DOIUrl":"https://doi.org/10.14427/jipai.2022.4.42","url":null,"abstract":"","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116940103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.14427/jipai.2022.4.47
O. Abramovskikh, E. Chetvernina
{"title":"Interleukin-10 in the differential diagnosis of bacteremia caused by gram-negative and gram-positive microorganisms in patients with sepsis","authors":"O. Abramovskikh, E. Chetvernina","doi":"10.14427/jipai.2022.4.47","DOIUrl":"https://doi.org/10.14427/jipai.2022.4.47","url":null,"abstract":"","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"72 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129671935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.14427/jipai.2022.4.86
Y. Yankovskaya, T. Chekanova, M. Kutateladze, K. Petremgvdlishvili, T. Chernobrovkina, A. Skryabina
{"title":"Challenges in the diagnosis of coxiellosis and the perspectives of personalized treatment","authors":"Y. Yankovskaya, T. Chekanova, M. Kutateladze, K. Petremgvdlishvili, T. Chernobrovkina, A. Skryabina","doi":"10.14427/jipai.2022.4.86","DOIUrl":"https://doi.org/10.14427/jipai.2022.4.86","url":null,"abstract":"","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127703717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.14427/jipai.2022.4.16
G. Terechenko, E. Levkova
{"title":"Combined hypersensitivity model in psoriasis and allergic diseases","authors":"G. Terechenko, E. Levkova","doi":"10.14427/jipai.2022.4.16","DOIUrl":"https://doi.org/10.14427/jipai.2022.4.16","url":null,"abstract":"","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"227 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121947178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.14427/jipai.2022.3.21
A. Khaliulin
Bloodstream infections still remain an urgent problem in many areas of medicine. Laboratory diagnosis of septic conditions is based on the microbiological examination of blood using automatic culture systems. Therefore, from the point of view of equipping a modern microbiological laboratory, it is important to evaluate the convergence of the laboratory data obtained when using certain hematological cultivators. An important factor is the timeliness of the appointment of etiotropic therapy, which depends on the time of issuance of a microbiological identification of the species of the microorganism isolated from the blood. This study assessed the convergence of data obtained using two hematological cultivators «Bact|ALERT 3D 60» and «Juno LABSTAR 100», and also described the main characteristics of the preanalytical stage of the accelerated microbiological identification method. It was found that the convergence of the results of hemocultivators is acceptable and identical microorganisms are detected in 98.6% of cases. Accelerated identification is also possible with the use of the described method using any of the devices included in the study. In addition, it was found that the preferred material for mass spectrometry is the sediment of microbial cells, for it yields a higher identification success rate.
血流感染在许多医学领域仍然是一个紧迫的问题。化脓性疾病的实验室诊断是基于使用自动培养系统对血液进行微生物学检查。因此，从装备现代化微生物实验室的角度来看，评估使用某些血液学培养器时获得的实验室数据的收敛性是很重要的。一个重要的因素是预约致病因治疗的及时性，这取决于从血液中分离的微生物种类的微生物鉴定的签发时间。本研究评估了使用两台血液学培养器“Bact|ALERT 3D 60”和“Juno LABSTAR 100”获得的数据的趋同性，并描述了加速微生物鉴定方法的分析前阶段的主要特征。结果表明，血液培养结果的收敛性是可以接受的，98.6%的病例检测到相同的微生物。使用本研究中包括的任何设备，也可以使用所描述的方法加速识别。此外，我们发现质谱分析的首选材料是微生物细胞的沉积物，因为它的鉴定成功率更高。
{"title":"Evaluation of analytical characteristics of blood culture and accelerated identification of microorganisms in bloodstream infections","authors":"A. Khaliulin","doi":"10.14427/jipai.2022.3.21","DOIUrl":"https://doi.org/10.14427/jipai.2022.3.21","url":null,"abstract":"Bloodstream infections still remain an urgent problem in many areas of medicine. Laboratory diagnosis of septic conditions is based on the microbiological examination of blood using automatic culture systems. Therefore, from the point of view of equipping a modern microbiological laboratory, it is important to evaluate the convergence of the laboratory data obtained when using certain hematological cultivators. An important factor is the timeliness of the appointment of etiotropic therapy, which depends on the time of issuance of a microbiological identification of the species of the microorganism isolated from the blood. This study assessed the convergence of data obtained using two hematological cultivators «Bact|ALERT 3D 60» and «Juno LABSTAR 100», and also described the main characteristics of the preanalytical stage of the accelerated microbiological identification method. It was found that the convergence of the results of hemocultivators is acceptable and identical microorganisms are detected in 98.6% of cases. Accelerated identification is also possible with the use of the described method using any of the devices included in the study. In addition, it was found that the preferred material for mass spectrometry is the sediment of microbial cells, for it yields a higher identification success rate.","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130835010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.14427/jipai.2022.3.70
V. Gorskii, V. Blyumina
The article discusses modern ideas about the mechanisms of development of atopic dermatitis. The role of the most significant pathogenetic factors (genetic factors, the influence of epidermal barrier disorders, the role of exogenous factors, immunological disorders, changes in the microbiome of the skin and intestines) is discussed. The results of research as well as data from domestic and foreign publications are presented.
{"title":"Modern concepts of the pathogenesis of atopic dermatitis","authors":"V. Gorskii, V. Blyumina","doi":"10.14427/jipai.2022.3.70","DOIUrl":"https://doi.org/10.14427/jipai.2022.3.70","url":null,"abstract":"The article discusses modern ideas about the mechanisms of development of atopic dermatitis. The role of the most significant pathogenetic factors (genetic factors, the influence of epidermal barrier disorders, the role of exogenous factors, immunological disorders, changes in the microbiome of the skin and intestines) is discussed. The results of research as well as data from domestic and foreign publications are presented.","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"448 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128862320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.14427/jipai.2022.3.77
A. Kuzmenkova
The aim of study. To study the local immune status in pediatric patients diagnosed with stomatitis. Objects and methods. The work is based on a retrospective and prospective analyses result research among 120 pediatric patients (4-12 years old) with stomatitis. Results. The results of patients' immunological examination with stomatitis are described. Research data (clinical, immunological) were analyzed using STATISTICA 10.0 software. In patients of the primary physical and histological period, the concentrations of α-amylase, lysozyme, myeloperoxidase, and secretory immunoglobulin A are increased. There is a lack of local immunity and production of immunoglobulin M. In pediatric patients related to the secondary period of physical and histological age features, the production of lysozyme, lactoferrin and myeloperoxidase, as well as immunoglobulin M and secretory immunoglobulin A, is reduced. Conclusion. From the results of this research, it is evident that there is a correlation between the physico-histological and immunological characteristics in children diagnosed with stomatitis.
{"title":"Clinical and immunological characteristics of pediatric patients with stomatitis","authors":"A. Kuzmenkova","doi":"10.14427/jipai.2022.3.77","DOIUrl":"https://doi.org/10.14427/jipai.2022.3.77","url":null,"abstract":"The aim of study. To study the local immune status in pediatric patients diagnosed with stomatitis. Objects and methods. The work is based on a retrospective and prospective analyses result research among 120 pediatric patients (4-12 years old) with stomatitis. Results. The results of patients' immunological examination with stomatitis are described. Research data (clinical, immunological) were analyzed using STATISTICA 10.0 software. In patients of the primary physical and histological period, the concentrations of α-amylase, lysozyme, myeloperoxidase, and secretory immunoglobulin A are increased. There is a lack of local immunity and production of immunoglobulin M. In pediatric patients related to the secondary period of physical and histological age features, the production of lysozyme, lactoferrin and myeloperoxidase, as well as immunoglobulin M and secretory immunoglobulin A, is reduced. Conclusion. From the results of this research, it is evident that there is a correlation between the physico-histological and immunological characteristics in children diagnosed with stomatitis.","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128772658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.14427/jipai.2022.3.40
D. Tereshko, I. Novitskaya
Introduction. C. immitis and C. posadasii are primary pathogens and are of reasonable interest in terms of their biological properties and, in particular, cytotoxic characteristics. Aim. To study the cytotoxicity of strains of coccidioidomycosis causative agents using the MTT test on in vitro models of cell lines. Materials and methods. Strains Coccidioides spp. were cultivated in a nutrient medium intended for cell lines. Cultures Wehi 3 and HEp-2 were exposed to sterile filtrates of the growth medium of causative agents of coccidioidomycosis in various dilutions, followed by measuring the mitochondrial activity of cells in the MTT-assay on day 4. The cytotoxic properties of fungi of the genus Coccidioides were assessed by calculating the cytotoxic concentration (СС50) of the metabolic products of micromycetes. Results. The most adequate cell model was selected, as well as the conditions for setting the MTT test for the in vitro study of the cytopathogenic effects of micromycetes of the genus Coccidioides were worked out. It was found that the strains Coccidioides spp. have different intensities of metabolite production, which, in turn, does not directly correlate with their cytotoxicity. By calculating the cytotoxic concentration (CC50), data were obtained on the cytotoxic properties of 7 collection strains of coccidioidomycosis pathogens in the mycelial growth phase. Conclusion. Based on the results of assessing the mitochondrial activity of cells of the lines Wehi 3 and HEp-2, the pronounced cytotoxic properties of the collection strains of coccidioidomycosis causative agents, which were subcultured in vitro for a long time, were confirmed.
{"title":"Analysis of the cytotoxic properties of collection strains of coccidioidomycosis causative agents","authors":"D. Tereshko, I. Novitskaya","doi":"10.14427/jipai.2022.3.40","DOIUrl":"https://doi.org/10.14427/jipai.2022.3.40","url":null,"abstract":"Introduction. C. immitis and C. posadasii are primary pathogens and are of reasonable interest in terms of their biological properties and, in particular, cytotoxic characteristics. Aim. To study the cytotoxicity of strains of coccidioidomycosis causative agents using the MTT test on in vitro models of cell lines. Materials and methods. Strains Coccidioides spp. were cultivated in a nutrient medium intended for cell lines. Cultures Wehi 3 and HEp-2 were exposed to sterile filtrates of the growth medium of causative agents of coccidioidomycosis in various dilutions, followed by measuring the mitochondrial activity of cells in the MTT-assay on day 4. The cytotoxic properties of fungi of the genus Coccidioides were assessed by calculating the cytotoxic concentration (СС50) of the metabolic products of micromycetes. Results. The most adequate cell model was selected, as well as the conditions for setting the MTT test for the in vitro study of the cytopathogenic effects of micromycetes of the genus Coccidioides were worked out. It was found that the strains Coccidioides spp. have different intensities of metabolite production, which, in turn, does not directly correlate with their cytotoxicity. By calculating the cytotoxic concentration (CC50), data were obtained on the cytotoxic properties of 7 collection strains of coccidioidomycosis pathogens in the mycelial growth phase. Conclusion. Based on the results of assessing the mitochondrial activity of cells of the lines Wehi 3 and HEp-2, the pronounced cytotoxic properties of the collection strains of coccidioidomycosis causative agents, which were subcultured in vitro for a long time, were confirmed.","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122276907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.14427/jipai.2022.3.83
V. Zemko, V. Okulich, A. Dzyadzko
Purpose: to study the main complications after heterotopic kidney transplantation according to retrospective analysis. Materials and methods. A retrospective study of 71 patient cards after heterotopic kidney transplantation in Vitebsk Regional Clinical Hospital from 2017 to 2021 was carried out. Results. The results of the study showed that the main causes of terminal chronic renal failure were malignant hypertension (32,4%), chronic glomerulonephritis (23,9%) and pyelonephritis (21,1%). The most common complications after heterotopic kidney transplantation were kidney and urinary tract infections: 13 cases (52%) and– 5 cases (20%). In 25 (35,2%) patients the causative agents of infectious complications were bacteria, in 1 – Candida spp. (1,4%). K. pneumoniae was isolated in 7 patients (28%), E. coli – 4 (16%), E. faecalis – 3 (12%), P. aeruginosa – 3 (12%), P. mirabilis – 2 (8%), Acinetobacter spp. – 2 (8%), Citrobacter spp. – 1 (4%), E. faecium – 1 (4%). Conclusion. The main reason for chronic renal failure and futher kidney transplantation was malignant hypertension (32,4%). The most common complications were kidney and urinary tract infections, including kidney transplant pyelonephritis and urinary tract infections. The causative agents of the above infections were predominantly bacteria and rarely fungi.
{"title":"Frequent complications in patients after heterotopic kidney transplant","authors":"V. Zemko, V. Okulich, A. Dzyadzko","doi":"10.14427/jipai.2022.3.83","DOIUrl":"https://doi.org/10.14427/jipai.2022.3.83","url":null,"abstract":"Purpose: to study the main complications after heterotopic kidney transplantation according to retrospective analysis. Materials and methods. A retrospective study of 71 patient cards after heterotopic kidney transplantation in Vitebsk Regional Clinical Hospital from 2017 to 2021 was carried out. Results. The results of the study showed that the main causes of terminal chronic renal failure were malignant hypertension (32,4%), chronic glomerulonephritis (23,9%) and pyelonephritis (21,1%). The most common complications after heterotopic kidney transplantation were kidney and urinary tract infections: 13 cases (52%) and– 5 cases (20%). In 25 (35,2%) patients the causative agents of infectious complications were bacteria, in 1 – Candida spp. (1,4%). K. pneumoniae was isolated in 7 patients (28%), E. coli – 4 (16%), E. faecalis – 3 (12%), P. aeruginosa – 3 (12%), P. mirabilis – 2 (8%), Acinetobacter spp. – 2 (8%), Citrobacter spp. – 1 (4%), E. faecium – 1 (4%). Conclusion. The main reason for chronic renal failure and futher kidney transplantation was malignant hypertension (32,4%). The most common complications were kidney and urinary tract infections, including kidney transplant pyelonephritis and urinary tract infections. The causative agents of the above infections were predominantly bacteria and rarely fungi.","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127494462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.14427/jipai.2022.3.57
T. Medvedeva, L. Leina, Y. Petunova, G. Chilina, P. Grib
Mycosis of the scalp is a common fungal disease. The optimal diagnosis is ensured by the combination of classical diagnostic tests with modern methods of molecular biology. The clinical picture of fungal infections of the scalp can be determined by the nature of the pathogen that caused ringworm (anthropophilic or zoophilic), the duration of the disease, and preceding therapy. The publication presents a case of a rare chronic infiltrative-suppurative microsporia of the scalp. The literature review reflects data on the etiology, epidemiology, and clinical picture of mycosis of the scalp.
{"title":"Tinea capitis: past and present","authors":"T. Medvedeva, L. Leina, Y. Petunova, G. Chilina, P. Grib","doi":"10.14427/jipai.2022.3.57","DOIUrl":"https://doi.org/10.14427/jipai.2022.3.57","url":null,"abstract":"Mycosis of the scalp is a common fungal disease. The optimal diagnosis is ensured by the combination of classical diagnostic tests with modern methods of molecular biology. The clinical picture of fungal infections of the scalp can be determined by the nature of the pathogen that caused ringworm (anthropophilic or zoophilic), the duration of the disease, and preceding therapy. The publication presents a case of a rare chronic infiltrative-suppurative microsporia of the scalp. The literature review reflects data on the etiology, epidemiology, and clinical picture of mycosis of the scalp.","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115800105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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