Pub Date : 2022-07-01DOI: 10.14427/jipai.2022.3.48
I. Novitskaya, L. Ryabinina
Mycotic infections are traditionally considered to be markers of immunodeficiency, however, primary mycoses develop even in immunocompetent individuals. Etiological agents of primary mycoses, which, according to the nomenclature adopted in the Russian Federation, are classified as particularly dangerous, are micromycetes of group II pathogenicity of the genera Coccidioides, Histoplasma, Paracoccidioides, Blastomyces. Particularly dangerous mycoses are common in certain geographical areas of the world: coccidioidomycosis occurs in semi-desert regions, histoplasmosis and paracoccidioidomycosis – in tropical areas, and blastomycosis – in temperate climate regions. However, despite the endemic nature of these diseases, they remain important both for European countries and the Russian Federation for a number of reasons, sporadic cases of particularly dangerous mycoses are regularly recorded in many European countries. It has been shown that several genetically determined factors are important for the implementation of the virulent properties of pathogenic fungi. Thermal dimorphism is of fundamental importance as a trigger for the transformation of a pathogen from a mycelial to a tissue (parasitic) growth phase, in which the causative agent of infection is able to fully realize its virulent properties.
{"title":"Primary mycoses and virulence of dimorphous particularly dangerous micromycetes","authors":"I. Novitskaya, L. Ryabinina","doi":"10.14427/jipai.2022.3.48","DOIUrl":"https://doi.org/10.14427/jipai.2022.3.48","url":null,"abstract":"Mycotic infections are traditionally considered to be markers of immunodeficiency, however, primary mycoses develop even in immunocompetent individuals. Etiological agents of primary mycoses, which, according to the nomenclature adopted in the Russian Federation, are classified as particularly dangerous, are micromycetes of group II pathogenicity of the genera Coccidioides, Histoplasma, Paracoccidioides, Blastomyces. Particularly dangerous mycoses are common in certain geographical areas of the world: coccidioidomycosis occurs in semi-desert regions, histoplasmosis and paracoccidioidomycosis – in tropical areas, and blastomycosis – in temperate climate regions. However, despite the endemic nature of these diseases, they remain important both for European countries and the Russian Federation for a number of reasons, sporadic cases of particularly dangerous mycoses are regularly recorded in many European countries. It has been shown that several genetically determined factors are important for the implementation of the virulent properties of pathogenic fungi. Thermal dimorphism is of fundamental importance as a trigger for the transformation of a pathogen from a mycelial to a tissue (parasitic) growth phase, in which the causative agent of infection is able to fully realize its virulent properties.","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115408706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The objective of this study was to investigate DNase, various types of proteolytic and oxidoreductase serum and abzyme activities, as well as the serum contents of free DNA in patients with breast tumors in accordance with the clinical, pathological and immunohistochemical characteristics of the tumors. It was found that catalytic antibodies isolated from blood serum of patients with breast oncopathology exhibit proteolytic, DNase and oxidoreductase activity, which varies depending on the course of the disease. It is worth noting that catalytic activity of IgAs (per unit of Ig concentration) can be 1-2 orders of magnitude higher than the analogous activity of IgGs. It was found that DNase, proteolytic (cathepsin G, cathepsin B) serum enzymatic activities and cathepsin G-like activity of IgG and IgA differ in patients with malignant and benign breast tumors and in healthy individuals. These parameters depend on the advance of the tumor process, histological and immunohistochemical characteristics of the tumor, as well as on the probability of tumor progression. In particular, the progression of the tumor process is accompanied by an increase of the activity of serum DNase and cathepsin B, decline of the concentration of patients` serum DNA, being also followed by marked changes of the nuclease, proteolytic and oxidoreductase activity of IgG and IgA.
{"title":"Catalytic activity of serum and immunoglobulins of classes G and A in patients with breast cancer","authors":"S. Zherulik, N. Lud, I. Generalov","doi":"10.14427/jipai.2022.3.6","DOIUrl":"https://doi.org/10.14427/jipai.2022.3.6","url":null,"abstract":"The objective of this study was to investigate DNase, various types of proteolytic and oxidoreductase serum and abzyme activities, as well as the serum contents of free DNA in patients with breast tumors in accordance with the clinical, pathological and immunohistochemical characteristics of the tumors. It was found that catalytic antibodies isolated from blood serum of patients with breast oncopathology exhibit proteolytic, DNase and oxidoreductase activity, which varies depending on the course of the disease. It is worth noting that catalytic activity of IgAs (per unit of Ig concentration) can be 1-2 orders of magnitude higher than the analogous activity of IgGs. It was found that DNase, proteolytic (cathepsin G, cathepsin B) serum enzymatic activities and cathepsin G-like activity of IgG and IgA differ in patients with malignant and benign breast tumors and in healthy individuals. These parameters depend on the advance of the tumor process, histological and immunohistochemical characteristics of the tumor, as well as on the probability of tumor progression. In particular, the progression of the tumor process is accompanied by an increase of the activity of serum DNase and cathepsin B, decline of the concentration of patients` serum DNA, being also followed by marked changes of the nuclease, proteolytic and oxidoreductase activity of IgG and IgA.","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124211929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.14427/jipai.2022.3.65
I. Khamaganova, S. Ermolaeva
The review presents problems of immunopathology of acantholytic pemphigus. Simultaneous increase of antibodies to desmoglein-1 and desmoglein-3 is revealed in pemphigus vulgaris and in pemphigus vegetans. In vulgar pemphigus with prevailing mucosal lesions the erosions appeared on the oral mucosa where desmoglein-3 was prevalent. The blister formation does not need complement activation as in other dermatoses, for the presence of framents of monoclonal antibody is sufficient. In pemphigus autoantibodies relate mainly to IgG4 subclass which does not activate complement, poorly activate effector cells through the Fc region and ineffectively crosslinks the antigen, which directly influences the desmosomal functions. In the case of atypical acantholytic pemphigus, non–desmoglein autoantigens may be revealed.
{"title":"Immunopathology of acantholytic pemphigus (review)","authors":"I. Khamaganova, S. Ermolaeva","doi":"10.14427/jipai.2022.3.65","DOIUrl":"https://doi.org/10.14427/jipai.2022.3.65","url":null,"abstract":"The review presents problems of immunopathology of acantholytic pemphigus. Simultaneous increase of antibodies to desmoglein-1 and desmoglein-3 is revealed in pemphigus vulgaris and in pemphigus vegetans. In vulgar pemphigus with prevailing mucosal lesions the erosions appeared on the oral mucosa where desmoglein-3 was prevalent. The blister formation does not need complement activation as in other dermatoses, for the presence of framents of monoclonal antibody is sufficient. In pemphigus autoantibodies relate mainly to IgG4 subclass which does not activate complement, poorly activate effector cells through the Fc region and ineffectively crosslinks the antigen, which directly influences the desmosomal functions. In the case of atypical acantholytic pemphigus, non–desmoglein autoantigens may be revealed.","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129751488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.14427/jipai.2022.3.30
Zh. Tsуrkunova, A. Emelyanova, E. Gudkova, G. Skorokhod, V. Butkevich, I. Slabko, N. Berdnik, I. Gavrilova
The purpose of the research is to study the effect of subinhibitory concentrations of biocides on the formation of adaptive resistance of clinical isolates of K. pneumoniae. The study analyzes the effect of chlorhexidine, benzalkonium chloride, povidone iodine, ethanol, glycolic acid, polyhexamethylene guanidine on the formation of adaptive resistance of clinical isolates of Kl. pneumoniae (n=9), isolated in 2021 from patients undergoing treatment in various departments of the oncological hospital in Minsk. Determination of the sensitivity of bacteria to biocides was carried out with the serial dilutions method in a dense nutrient medium and with the serial microdilutions method in a liquid nutrient medium, using a twofold dilution of each antimicrobial substance. Throughout the course of the research, it was found that subcultivation of clinical isolates of K. pneumoniae on media with subinhibitory concentrations of chlorhexidine and benzalkonium chloride led to 60 and 40 times increase in bacterial resistance to them, respectively. It was shown that variability which does not affect the bacterial genome makes the maximum contribution to the development of resistance of K. pneumoniae clinical isolates to chlorhexidine, and both phenotypic and mutational variability to benzalkonium chloride. Povidone iodine, ethanol and glycolic acid did not cause the development of adaptive resistance of microorganisms. The results obtained indicate that the irrational and uncontrolled use of antiseptic and disinfectants containing chlorhexidine and benzalkonium chloride as active substances can lead to the development of adaptive resistance of microorganisms and thereby reduce the effectiveness of preventive and therapeutic measures.
{"title":"Effect of subinhibitory concentrations of biocides on formation of adaptive resistance of clinical isolates of Klebsiella pneumoniae","authors":"Zh. Tsуrkunova, A. Emelyanova, E. Gudkova, G. Skorokhod, V. Butkevich, I. Slabko, N. Berdnik, I. Gavrilova","doi":"10.14427/jipai.2022.3.30","DOIUrl":"https://doi.org/10.14427/jipai.2022.3.30","url":null,"abstract":"The purpose of the research is to study the effect of subinhibitory concentrations of biocides on the formation of adaptive resistance of clinical isolates of K. pneumoniae. The study analyzes the effect of chlorhexidine, benzalkonium chloride, povidone iodine, ethanol, glycolic acid, polyhexamethylene guanidine on the formation of adaptive resistance of clinical isolates of Kl. pneumoniae (n=9), isolated in 2021 from patients undergoing treatment in various departments of the oncological hospital in Minsk. Determination of the sensitivity of bacteria to biocides was carried out with the serial dilutions method in a dense nutrient medium and with the serial microdilutions method in a liquid nutrient medium, using a twofold dilution of each antimicrobial substance. Throughout the course of the research, it was found that subcultivation of clinical isolates of K. pneumoniae on media with subinhibitory concentrations of chlorhexidine and benzalkonium chloride led to 60 and 40 times increase in bacterial resistance to them, respectively. It was shown that variability which does not affect the bacterial genome makes the maximum contribution to the development of resistance of K. pneumoniae clinical isolates to chlorhexidine, and both phenotypic and mutational variability to benzalkonium chloride. Povidone iodine, ethanol and glycolic acid did not cause the development of adaptive resistance of microorganisms. The results obtained indicate that the irrational and uncontrolled use of antiseptic and disinfectants containing chlorhexidine and benzalkonium chloride as active substances can lead to the development of adaptive resistance of microorganisms and thereby reduce the effectiveness of preventive and therapeutic measures.","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128258410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.14427/jipai.2022.2.62
I. Kozyro
The observation data of 22 children with systemic vasculitis (SV) and morphologically verified nephritis is presented. Emphasis was put on extrarenal manifestations of SV in childhood, analysis of clinical, laboratory, immunological, morphological changes and factors influencing on the course and prognosis. It has been established that SV often manifests with general non-specific constitutional symptoms, involvement of the ENT and organs of vision, is characterized by multiple organ and generalized lesions, in 77% of cases in children is associated with anti-neutrophil cytoplasmic antibodies (ANCA). The presence of antibodies to myeloperoxidase (MPO) is noted in most patients with lesions of the skin, joints, lungs, and nervous system and is associated with an unfavorable renal prognosis. ENT and organs of vision, gastrointestinal tract involvement is equally often observed in both MPO and PR3 antibody positive.
{"title":"Extrarenal manifestations of systemic vasculitis in children","authors":"I. Kozyro","doi":"10.14427/jipai.2022.2.62","DOIUrl":"https://doi.org/10.14427/jipai.2022.2.62","url":null,"abstract":"The observation data of 22 children with systemic vasculitis (SV) and morphologically verified nephritis is presented. Emphasis was put on extrarenal manifestations of SV in childhood, analysis of clinical, laboratory, immunological, morphological changes and factors influencing on the course and prognosis. It has been established that SV often manifests with general non-specific constitutional symptoms, involvement of the ENT and organs of vision, is characterized by multiple organ and generalized lesions, in 77% of cases in children is associated with anti-neutrophil cytoplasmic antibodies (ANCA). The presence of antibodies to myeloperoxidase (MPO) is noted in most patients with lesions of the skin, joints, lungs, and nervous system and is associated with an unfavorable renal prognosis. ENT and organs of vision, gastrointestinal tract involvement is equally often observed in both MPO and PR3 antibody positive.","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114298971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.14427/jipai.2022.2.19
V. Gorbachev, T. Dmitrachenko, V. Semenov, S. Egorov
Cytomegalovirus is a frequent contributor to the infectious process in critically ill patients and may contribute to the clinical outcome of the disease. This study aimed to determine the presence and frequency of HCMV reactivation and contributing factors in critically ill patients with severe bacterial comorbidity. Plasma and sputum samples were collected from 82 patients to determine the frequency of reactivation. HCMV reactivation was determined by the detection of HCMV DNA along with the presence of IgG to HCMV. HCMV reactivation was detected in 36.6% of cases. The presence of sepsis was associated with a higher probability of HCMV reactivation (p<0.01), as well as higher HCMV viral loads both in the blood and sputum of patients in these groups. An association between the presence of HCMV in biological fluids and subsequent development of sepsis in patients with severe bacterial pathology (OR=1.5) was detected.
{"title":"Reactivation of cytomegalovirus infection in sepsis and severe bacterial comorbidity","authors":"V. Gorbachev, T. Dmitrachenko, V. Semenov, S. Egorov","doi":"10.14427/jipai.2022.2.19","DOIUrl":"https://doi.org/10.14427/jipai.2022.2.19","url":null,"abstract":"Cytomegalovirus is a frequent contributor to the infectious process in critically ill patients and may contribute to the clinical outcome of the disease. This study aimed to determine the presence and frequency of HCMV reactivation and contributing factors in critically ill patients with severe bacterial comorbidity. Plasma and sputum samples were collected from 82 patients to determine the frequency of reactivation. HCMV reactivation was determined by the detection of HCMV DNA along with the presence of IgG to HCMV. HCMV reactivation was detected in 36.6% of cases. The presence of sepsis was associated with a higher probability of HCMV reactivation (p<0.01), as well as higher HCMV viral loads both in the blood and sputum of patients in these groups. An association between the presence of HCMV in biological fluids and subsequent development of sepsis in patients with severe bacterial pathology (OR=1.5) was detected.","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124431744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.14427/jipai.2022.2.35
O. Chernokov, I. Shchurok
For more than two years the whole world has been ensnared by the COVID-19 pandemic caused by SARS-COV-2. Every day in Belarus, more and more new cases of the disease are detected, the number of deaths continues to grow. Currently, according to Johns Hopkins University in our country, there are more than 930 thousand confirmed cases of coronavirus infection and more than 6 thousand deaths [1]. Therefore, the introduction of a new diagnostic tool can help not only reduce the lethality of this disease, but also help optimize the use of hospital beds, which will provide the possibility of using timely targeted therapy. As a result of the study, the high specificity (80.4%) of the COVID-GRAM Critical Illness Risk Score calculator was confirmed, and high significant differences (p=0.004) were obtained, which allows us to recommend it as a starting point when developing more sensitive forecasting methods.
{"title":"Predicting the severity of COVID-19","authors":"O. Chernokov, I. Shchurok","doi":"10.14427/jipai.2022.2.35","DOIUrl":"https://doi.org/10.14427/jipai.2022.2.35","url":null,"abstract":"For more than two years the whole world has been ensnared by the COVID-19 pandemic caused by SARS-COV-2. Every day in Belarus, more and more new cases of the disease are detected, the number of deaths continues to grow. Currently, according to Johns Hopkins University in our country, there are more than 930 thousand confirmed cases of coronavirus infection and more than 6 thousand deaths [1]. Therefore, the introduction of a new diagnostic tool can help not only reduce the lethality of this disease, but also help optimize the use of hospital beds, which will provide the possibility of using timely targeted therapy. As a result of the study, the high specificity (80.4%) of the COVID-GRAM Critical Illness Risk Score calculator was confirmed, and high significant differences (p=0.004) were obtained, which allows us to recommend it as a starting point when developing more sensitive forecasting methods.","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130733211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.14427/jipai.2022.2.55
Y. Kandrashkina, E. Orlova
Purpose of the study: to assess the psycho-emotional state and the level of filaggrin in the blood serum of pregnant women with exacerbation of atopic dermatitis (AtD). Materials and methods. The study included 70 pregnant women with AtD, 20 non-pregnant women with AtD, 20 healthy pregnant women. A survey was conducted on the Beck Depression and Anxiety Scale. The filaggrin level in the blood serum was assessed by ELISA. Research results. Serum filaggrin levels in pregnant women with AtD were significantly higher than in non-pregnant women with AD (p=0.007) and healthy pregnant women (p=0.001). The level of anxiety was increased in the groups with AtD compared with the group of healthy pregnant women (p=0.001). The level of depression in pregnant women with AtD was higher than in healthy pregnant women (p=0.002) and non-pregnant women with AtD (p=0.021). Conclusions. It was found that pregnant women with AtD have more pronounced disorders of the psycho-emotional state and a higher level of filaggrin in the blood serum than non-pregnant women with AtD and healthy pregnant women.
{"title":"Psychoemotional state and filaggrin level in pregnant women with atopic dermatitis","authors":"Y. Kandrashkina, E. Orlova","doi":"10.14427/jipai.2022.2.55","DOIUrl":"https://doi.org/10.14427/jipai.2022.2.55","url":null,"abstract":"Purpose of the study: to assess the psycho-emotional state and the level of filaggrin in the blood serum of pregnant women with exacerbation of atopic dermatitis (AtD). Materials and methods. The study included 70 pregnant women with AtD, 20 non-pregnant women with AtD, 20 healthy pregnant women. A survey was conducted on the Beck Depression and Anxiety Scale. The filaggrin level in the blood serum was assessed by ELISA. Research results. Serum filaggrin levels in pregnant women with AtD were significantly higher than in non-pregnant women with AD (p=0.007) and healthy pregnant women (p=0.001). The level of anxiety was increased in the groups with AtD compared with the group of healthy pregnant women (p=0.001). The level of depression in pregnant women with AtD was higher than in healthy pregnant women (p=0.002) and non-pregnant women with AtD (p=0.021). Conclusions. It was found that pregnant women with AtD have more pronounced disorders of the psycho-emotional state and a higher level of filaggrin in the blood serum than non-pregnant women with AtD and healthy pregnant women.","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116449606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.14427/jipai.2022.2.12
I. Guryanova, K. Skapavets, A. Liubushkin, E. Polyakova, I. Ausianik, S. Aleshkevich, A. Salivonchik, V. Vertelko, Y. Zharankova, M. Belevtsev
Introduction. Hereditary angioedema (HAE) is a rare, difficult to diagnose, and life-threatening genetic disorder with an expected incidence of about 1:30 000. Purpose. To study the demographic characteristics in a cohort of patients with genetically confirmed hereditary angioedema in the Republic of Belarus. Materials and methods. The study included 92 Belarusian patients from 34 unrelated families with genetically confirmed HAE, the ratio of male and female patients was 1:1.3. Clinical and demographic data was taken from patient questionnaires and/or medical records. Results. The median age of tpatients was 32 years, and the median age at diagnosis was 28 years. The onset of the disease in 72% of patients occurred before the age of 18 years (median 13 years), the median delay from the onset of the first symptoms and the diagnosis of HAE was 12.5 years. Half of male patients develop first attacks before the age 9, and 90% by the age of 20. Of female patients, 50 and 90% have first attacks before the age of 15 and 23, respectively.
{"title":"Demographic characteristics of patients with genetically confirmed hereditary angioedema in the Republic of Belarus","authors":"I. Guryanova, K. Skapavets, A. Liubushkin, E. Polyakova, I. Ausianik, S. Aleshkevich, A. Salivonchik, V. Vertelko, Y. Zharankova, M. Belevtsev","doi":"10.14427/jipai.2022.2.12","DOIUrl":"https://doi.org/10.14427/jipai.2022.2.12","url":null,"abstract":"Introduction. Hereditary angioedema (HAE) is a rare, difficult to diagnose, and life-threatening genetic disorder with an expected incidence of about 1:30 000. Purpose. To study the demographic characteristics in a cohort of patients with genetically confirmed hereditary angioedema in the Republic of Belarus. Materials and methods. The study included 92 Belarusian patients from 34 unrelated families with genetically confirmed HAE, the ratio of male and female patients was 1:1.3. Clinical and demographic data was taken from patient questionnaires and/or medical records. Results. The median age of tpatients was 32 years, and the median age at diagnosis was 28 years. The onset of the disease in 72% of patients occurred before the age of 18 years (median 13 years), the median delay from the onset of the first symptoms and the diagnosis of HAE was 12.5 years. Half of male patients develop first attacks before the age 9, and 90% by the age of 20. Of female patients, 50 and 90% have first attacks before the age of 15 and 23, respectively.","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134412422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.14427/jipai.2022.2.31
L. Surkova, A. Strinovich, O. Budnik, A. Bahtina
Objective: to determine the capabilities of the quantiferon test in detecting latent tuberculosis infection in patients with comorbid pathology. Materials and methods. A retrospective analysis of the quantiferon test results was carried out in 420 patients with suspected tuberculosis or with a hyperergic Mantoux or Diaskintest reaction using the QuantiFERON-TB Gold Plus test system (Qiagen, Germany). Results. Different levels of tuberculosis infection were established in different age groups of patients with comorbid pathology, with a higher infection rate at a young age – 21.42%. The shift of tuberculosis infection to an older age group (61-70 years) was determined – 16.32%. Latent tuberculosis infection was significantly more often detected in patients with comorbid pathology compared to healthy individuals (59.0% and 32.78%, respectively, χ2=8.45, p=0.004). Conclusion. The data obtained confirms the assumption of a high level of latent tuberculosis infection in patients with comorbid pathology.
{"title":"Possibilities of quantiferon test in detection of latent tb infection","authors":"L. Surkova, A. Strinovich, O. Budnik, A. Bahtina","doi":"10.14427/jipai.2022.2.31","DOIUrl":"https://doi.org/10.14427/jipai.2022.2.31","url":null,"abstract":"Objective: to determine the capabilities of the quantiferon test in detecting latent tuberculosis infection in patients with comorbid pathology. Materials and methods. A retrospective analysis of the quantiferon test results was carried out in 420 patients with suspected tuberculosis or with a hyperergic Mantoux or Diaskintest reaction using the QuantiFERON-TB Gold Plus test system (Qiagen, Germany). Results. Different levels of tuberculosis infection were established in different age groups of patients with comorbid pathology, with a higher infection rate at a young age – 21.42%. The shift of tuberculosis infection to an older age group (61-70 years) was determined – 16.32%. Latent tuberculosis infection was significantly more often detected in patients with comorbid pathology compared to healthy individuals (59.0% and 32.78%, respectively, χ2=8.45, p=0.004). Conclusion. The data obtained confirms the assumption of a high level of latent tuberculosis infection in patients with comorbid pathology.","PeriodicalId":425120,"journal":{"name":"Immunopathology, Allergology, Infectology","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134193674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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