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Executive function deficits associated with anxiety and depression and their impact on medical students’ academic performance in Saudi Arabia 沙特阿拉伯与焦虑和抑郁相关的执行功能缺陷及其对医学生学业成绩的影响
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-10-26 DOI: 10.22317/jcms.v8i5.1290
Sulhi A. Alfakeh, A. Alharbi, Mohammed K. Alhebshi, Abdullah F. Attar
Objectives: This study aimed to determine the relationship between EF deficits associated with anxiety and depression and their impact on medical students’ academic achievement in Saudi universities. Methods: A cross-sectional online survey was conducted on 242 medical students. Anxiety and depression were assessed using the Barkley Deficits in Executive Functioning Scale (BDEFS), General Anxiety Disorder-7 scale (GAD-7), and the Patient Health Questionnaire (PHQ-9). Results: Participants’ mean age was 22.57 (2.26) years and the mean GAD-7, PHQ-9, and BDEFS scores were 10.54 (5.83), 12.29 (6.86), and 196.78 (47.78), respectively. Males, Saudi students, those in their fourth academic year, and those who were not satisfied with their academic performance had significantly higher mean GAD-7, PHQ-9, and BDEFS scores. A significant negative association was found between students’ grade point average (GPA) and BDEFS scores, and a significant positive association was found between GPA and GAD-7 scale scores, PHQ-9 scores, and BDEFS scores. Additionally, there was a positive association between the PHQ-9 and BDEFS scores. Conclusion: A real-world application of EF scales to address EF deficits for all university students should be considered.
目的:本研究旨在确定与焦虑和抑郁相关的EF缺陷与其对沙特大学医学生学业成绩的影响之间的关系。方法:对242名医学生进行横断面在线调查。使用Barkley执行功能缺陷量表(BDEFS)、一般焦虑障碍-7量表(GAD-7)和患者健康问卷(PHQ-9)评估焦虑和抑郁。结果:参与者的平均年龄为22.57(2.26)岁,GAD-7、PHQ-9和BDEFS的平均得分分别为10.54(5.83)、12.29(6.86)和196.78(47.78)。男性、沙特学生、第四学年学生和对学习成绩不满意的学生的GAD-7、PHQ-9和BDEFS平均得分显著较高。学生的平均绩点(GPA)与BDEFS得分之间存在显著的负相关,GPA与GAD-7量表得分、PHQ-9得分和BDEFS分数之间存在显著正相关。此外,PHQ-9和BDEFS评分之间存在正相关。结论:应考虑在现实世界中应用EF量表来解决所有大学生的EF缺陷。
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引用次数: 0
Femoral and Popliteal Artery Pathway in Varus and valgus aligned lower limb; a CT Angiographic study 内翻、外翻对准下肢的股腘动脉通路CT血管造影研究
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-10-26 DOI: 10.22317/jcms.v8i5.1280
S. Kazemi, S. Keyhani, Mohamad Qoreishi, Saman Shakeri Jousheghan, Reza Minaei Noshahr
Objectives: This study aimed to compare the femoral and popliteal arteries pathway in varus and valgus- aligned lower limbs. Methods: A retrospective CT angiography (CTA) study from October to December 2021 was conducted. Distance of the femoral and popliteal artery to specific bony landmarks in thigh and knee was measured. Results: Eighty limbs including 40 varus and 40 valgus lower limbs were assessed. No significant difference between varus/valgus groups in terms of distances was noted. Conclusion: Our study compared pathway of PA and FA artery in varus and valgus knees using CTA images; and no significant differences was seen between the two groups of varus and valus.
目的:本研究旨在比较下肢内翻和外翻的股动脉和腘动脉通路。方法:于2021年10月至12月进行回顾性CT血管造影(CTA)研究。测量股骨和腘动脉到大腿和膝盖特定骨标志的距离。结果:共检查80条肢体,其中下肢内翻40条,外翻40条。内翻/外翻组在距离方面无显著差异。结论:本研究比较了膝关节内翻和外翻的CTA图像中PA和FA动脉的通路;两组内翻和外翻无明显差异。
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引用次数: 0
Relationship of Midkine in Myocardial Infarction patients and some biochemical parameters 心肌梗死患者Midkine与某些生化指标的关系
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-08-26 DOI: 10.22317/jcms.v8i4.1255
Obeda Abdlkhaliq Abass Alkado, Luay Abd Ali Al-Helaly
Objectives: This study aims to estimate the concentrations of MK, hs-CRP, TnI, AST, ALT and ALP in serum for MI in comparison to wholesome controls, in an effort to check the quantity of this impact at the pathological condition, in addition to understanding the position of MK in MI sufferers and its relationship to liver function tests and may be used as biochemical markers to decide the severity of MI in sufferers. Methods: The studying include the investigation of midkine (MK), High-sensitivity C-reactive protein (hs-CRP), Troponin I (TnI), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and alkaline phosphatase (ALP) levels in myocardial infarction (MI) patients. The study includes (84) samples: 34 of myocardial infarction patients (19 male and 15 female) and 50 sample of apparently healthy as control group (25 male and 25 female). Samples were collected during the period from Jan. 2021 to July 2021 from in-patients of Cardiac Surgery Center admitted at Ibn Sina Teaching Hospital and Mosul General Hospital, Mosul, Iraq with matching age ranged between 26-86 years. The clinical diagnosis in each case is made according to a cardiovascular specialist. Results: The results showed that there was a significant increase in MK, TnI, GOT, GPT and ALP for all studied groups (males and females) of MI patients compared with control groups, and there was no any a significant in hs-CRP. Beside of, showed significant positive correlation between MK with BMI, hs-CRP, TnI, AST, ALT and ALP in control and patients group. Whereas there were no any correlation between MK with age, in patients and control under study. Conclusion: The study indicated that the MK increased in patients with myocardial infarction, and it’s increased in males more than female patients, and that may act as a good markers for diagnosis of myocardial infarction disease.
目的:本研究旨在评估心肌梗死患者血清中MK、hs-CRP、TnI、AST、ALT和ALP的浓度,并与健康对照组进行比较,以检查其在病理状态下的影响程度,了解MK在心肌梗死患者中的位置及其与肝功能检查的关系,并可作为判断心肌梗死患者严重程度的生化指标。方法:研究心肌梗死(MI)患者血清midkine (MK)、高敏c反应蛋白(hs-CRP)、肌钙蛋白I (TnI)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)和碱性磷酸酶(ALP)水平。本研究共纳入84例样本:心肌梗死患者34例(男19例,女15例)和表面健康的对照组50例(男25例,女25例)。样本采集于2021年1月至2021年7月,来自伊拉克摩苏尔伊本西纳教学医院和摩苏尔总医院心脏外科中心的住院患者,匹配年龄在26-86岁之间。每个病例的临床诊断都是由心血管专家做出的。结果:MI患者各研究组(男、女)MK、TnI、GOT、GPT、ALP均较对照组显著升高,hs-CRP无显著升高。此外,MK与对照组和患者组BMI、hs-CRP、TnI、AST、ALT、ALP呈显著正相关。然而,在患者和对照组中,MK与年龄之间没有任何相关性。结论:本研究提示心肌梗死患者MK升高,且男性高于女性,可作为心肌梗死疾病诊断的良好指标。
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引用次数: 0
Elongated Mental Spine with Two Lingual Foramina in the Mandible of A Kurdish Woman: A Case Report 一名库尔德妇女下颌两个舌膜的细长精神脊柱:一例报告
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-08-26 DOI: 10.22317/jcms.v8i4.1235
F. Hagi, Yaseen Sedeeq Yaseen, Liqaa Jabir Hassan
The mental spines are bony prominences found in the lingual surface of anterior mandible, and usually they are arranged in two groups, superior pair and inferior pair. Mostly they are asymptomatic, but sometimes they may interfere with the prosthodontic treatment or with some surgeries. The lingual foramen can be found in different locations around the mental spines, and they are very important vital organ because they transmit nerves and arteries, which may cause a serious problem during some types of surgeries in this region such as implant placement. Here, we report a case of 55-year-old, Kurdish woman with elongated superior mental spine with bilaterally lingual foramina located distally to lower central incisors, that have been seen during a routine CBCT scan. The length of the spine was 6.4 mm, the height was 5.5 mm and the width was 1.9 mm. So, any dentist wants to perform any type of surgery in sublingual and submental regions should be careful of such anatomical variations.
颏棘是位于前下颌骨舌表面的骨突起,通常分为上对和下对两组。大多数情况下,它们是无症状的,但有时它们可能会干扰口腔修复治疗或一些手术。舌孔可以在精神棘周围的不同位置找到,它们是非常重要的重要器官,因为它们传递神经和动脉,这可能会在该区域的某些类型的手术中造成严重问题,例如植入物的放置。在这里,我们报告了一例55岁的库尔德妇女,她患有细长的上精神棘,双侧舌孔位于下中切牙的远端,这是在常规CBCT扫描中看到的。脊椎长度为6.4毫米,高度为5.5毫米,宽度为1.9毫米。因此,任何想在舌下和颏下区域进行任何类型手术的牙医都应该小心这种解剖变异。
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引用次数: 0
Measurement of the serum level of Leucine-rich alpha-2-glycoprotein-1 in hospitalized Iraqi COVID-19 Patients 伊拉克新冠肺炎住院患者血清富亮氨酸α -2糖蛋白-1水平测定
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-08-26 DOI: 10.22317/jcms.v8i4.1232
Maha hassan Gadhi, Eman S. Saleh
Objective: The study aimed to assess Leucine-rich alpha-2-glycoprotein-1 biomarker serum level in hospitalized COVID-19 patients.Methods: The case control study from multi-centers in Baghdad included 45 adult patients (19 females and 26 males) with COVID-19, diagnosed with a positive real-time reverse transcription polymerase chain reaction and excluded negative RT-PCR for COVID-19 and comorbidity conditions. Second group, was 43 control (20 females and 23 males).Results: This study found a decrease Leucine-rich alpha-2-glycoprotein-1 biomarker serum level in these patients and a significant difference in D. dimer, neutrophil count, lymphocyte count, and the neutrophil-lymphocyte ratio between the patients and controls at a P value equal to 0.000,Conclusion: The concentration of leucine-rich alpha2 glycoprotien1 in the patients after taking Tocilizumab was greatly decreased in many studies. Most of the patients in the study were treated with Tocilizumab, which directly blocks the effect of IL-6 by blocking the IL-6 receptors and greatly decreased the expression of LRG1 to impair the production of the angiopathogenic constituent.
目的:本研究旨在评估新冠肺炎住院患者血清中富含亮氨酸的α-2-糖蛋白-1生物标志物水平。方法:巴格达多中心的病例对照研究包括45名成年新冠肺炎患者(19名女性和26名男性),他们被诊断为实时逆转录聚合酶链反应阳性,排除了新冠肺炎和合并症的阴性RT-PCR。第二组为43名对照组(20名女性和23名男性)。结果:本研究发现,这些患者富含亮氨酸的α-2-糖蛋白-1生物标志物血清水平降低,患者和对照组之间的D.二聚体、中性粒细胞计数、淋巴细胞计数和中性粒细胞-淋巴细胞比率存在显著差异,P值等于0.000,结论:在许多研究中,服用托奇利珠单抗的患者体内富含亮氨酸的α2-糖蛋白1的浓度显著降低。研究中的大多数患者都接受了托奇利珠单抗治疗,托奇利单抗通过阻断IL-6受体直接阻断IL-6的作用,并大大降低LRG1的表达,从而损害血管致病成分的产生。
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引用次数: 0
The association between iron deficiency anemia and obesity in children 儿童缺铁性贫血与肥胖的关系
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-08-26 DOI: 10.22317/jcms.v8i4.1236
A. Atrushi, Farhad Armishty, Sirwan A. Saleh, Mehvan Sh. Abdulrahman
Objectives: To examine the association between obesity and iron status and the presence of iron deficiency anemia in children.Methods: This case-control study included 100 children between 2-14 years of age who were divided into two age- and sex- matched equal groups of 50 children each. Children with a body mass index (BMI) greater than or equal to 95th centile were categorized as obese while the other 50 children with a BMI greater than or equal to 5th centile but less than 95th centile were considered the normal weight group. Children with cardiac disease, liver disease, chronic gastrointestinal disease and chronic hematologic disorders except iron deficiency (with or without anemia) and those taking Vitamin or mineral supplements regularly during the previous year were excluded.  Each participant was sent for serum iron, ferritin, total iron binding capacity (TIBC), transferrin saturation TS and complete blood count. Iron deficiency is defined as Transferrin Saturation (TS) lower than 16% and IDA is defined as TS lower than 16% and hemoglobin (Hb) concentration lower than 120 g/l or 12 mg/dl for children. The data were analyzed using SPSS-23 software and for all data normal distribution was tested so that P-value<0.05 is the level of threshold for statistical significance.Results: The gender distribution between the both group is reversed with male being more common in obese group but no statistical difference. The age distribution shows dominance of the age group 5-10 years in the both group with some differences which are of no statistical significance (P=0.294). The values of Hemoglobin, serum iron, serum ferritin, total iron binding capacity and transferrin saturation are obviously similar between the both genders of the whole study population with no statistically significant differences (P=0.084, 0.469, 0.48,0.4, 0.571 respectively). Obese children have higher level of Hemoglobin(P=0.069), Ferritin(P=0.5) and total iron binding capacity(P=0.449) but lower levels of serum iron (P =0.234) and transferrin saturation(P=0.45) but with no statistical significance.Conclusion: There is no significant association between obesity and iron status and the presence of iron deficiency anemia despite a lower level of serum iron and lower transferrin saturation in obese than normal weight children.
目的:研究肥胖与铁状况以及儿童缺铁性贫血之间的关系。方法:这项病例对照研究包括100名2-14岁的儿童,他们被分为两组,每组50名年龄和性别匹配的儿童。体重指数(BMI)大于或等于第95百分位数的儿童被归类为肥胖,而其他50名体重指数大于或等于5百分位数但小于第95百分位数的儿童则被视为正常体重组。患有心脏病、肝病、慢性胃肠道疾病和慢性血液系统疾病(除缺铁(伴有或不伴有贫血))的儿童以及前一年定期服用维生素或矿物质补充剂的儿童除外。每位参与者都被送去检测血清铁、铁蛋白、总铁结合能力(TIBC)、转铁蛋白饱和度TS和全血细胞计数。儿童缺铁定义为转铁蛋白饱和度(TS)低于16%,IDA定义为TS低于16%,血红蛋白(Hb)浓度低于120 g/l或12 mg/dl。使用SPSS-23软件对数据进行分析,并对所有数据进行正态分布测试,使得P值<0.05是统计显著性的阈值水平。结果:两组之间的性别分布相反,男性在肥胖组中更常见,但无统计学差异。年龄分布在两组中均以5-10岁年龄组为主,差异无统计学意义(P=0.294),整个研究人群的总铁结合能力和转铁蛋白饱和度在两性之间明显相似,无统计学显著差异(分别为P=0.084、0.469、0.48、0.4、0.571)。肥胖儿童的血红蛋白(P=0.069)、铁蛋白(P=0.5)和总铁结合能力(P=0.449)水平较高,但血清铁(P=0.234)和转铁蛋白饱和度(P=0.45)水平较低,但无统计学意义。结论:尽管肥胖儿童的血清铁水平和转铁蛋白饱和度低于正常体重儿童,但肥胖与铁状况和缺铁性贫血之间没有显著关联。
{"title":"The association between iron deficiency anemia and obesity in children","authors":"A. Atrushi, Farhad Armishty, Sirwan A. Saleh, Mehvan Sh. Abdulrahman","doi":"10.22317/jcms.v8i4.1236","DOIUrl":"https://doi.org/10.22317/jcms.v8i4.1236","url":null,"abstract":"Objectives: To examine the association between obesity and iron status and the presence of iron deficiency anemia in children.\u0000Methods: This case-control study included 100 children between 2-14 years of age who were divided into two age- and sex- matched equal groups of 50 children each. Children with a body mass index (BMI) greater than or equal to 95th centile were categorized as obese while the other 50 children with a BMI greater than or equal to 5th centile but less than 95th centile were considered the normal weight group. Children with cardiac disease, liver disease, chronic gastrointestinal disease and chronic hematologic disorders except iron deficiency (with or without anemia) and those taking Vitamin or mineral supplements regularly during the previous year were excluded.  Each participant was sent for serum iron, ferritin, total iron binding capacity (TIBC), transferrin saturation TS and complete blood count. Iron deficiency is defined as Transferrin Saturation (TS) lower than 16% and IDA is defined as TS lower than 16% and hemoglobin (Hb) concentration lower than 120 g/l or 12 mg/dl for children. The data were analyzed using SPSS-23 software and for all data normal distribution was tested so that P-value<0.05 is the level of threshold for statistical significance.\u0000Results: The gender distribution between the both group is reversed with male being more common in obese group but no statistical difference. The age distribution shows dominance of the age group 5-10 years in the both group with some differences which are of no statistical significance (P=0.294). The values of Hemoglobin, serum iron, serum ferritin, total iron binding capacity and transferrin saturation are obviously similar between the both genders of the whole study population with no statistically significant differences (P=0.084, 0.469, 0.48,0.4, 0.571 respectively). Obese children have higher level of Hemoglobin(P=0.069), Ferritin(P=0.5) and total iron binding capacity(P=0.449) but lower levels of serum iron (P =0.234) and transferrin saturation(P=0.45) but with no statistical significance.\u0000Conclusion: There is no significant association between obesity and iron status and the presence of iron deficiency anemia despite a lower level of serum iron and lower transferrin saturation in obese than normal weight children.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43795774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Evaluation of Elementary School Teachers’ Knowledge about Attention Deficit Hyperactivity Disorder (ADHD) 小学教师关于注意缺陷多动障碍(ADHD)知识的评价
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-08-26 DOI: 10.22317/jcms.v8i4.1251
Ashwan Samir Hamed, Hawraa Hussein Ghafel
Objectives: This study aimed to evaluate elementary school teachers’ knowledge about Attention Deficit Hyperactivity Disorder in AL-Diwaniyah City. Methods: A quantitative research, descriptive correlational design was used in this study, the study conducted on teachers at elementary schools in AL-Diwaniyah City from (20th September 2021 to 30th June, 2022) to evaluate of elementary school teachers knowledge about attention deficit hyperactivity disorder. The sample consist of (354) elementary school teachers were participated in the study. A non-probability sampling (convenience sample). The sample size was detected by using the sample size formula which is obtained from Steven K. Thompson, (2012). To determine the effect sample size regarding the population size. Results: The findings indicates that 68.6% of teachers show fair level of knowledge about attention deficit hyperactivity disorders (23.90±6.989). Conclusion: Considering the results discussion and their interpretations, the study concludes that the knowledge of the elementary school teachers in AL-Diwaniyah City at fair level regarding ADHD.
目的:了解AL-Diwaniyah市小学教师对注意缺陷多动障碍的认知情况。方法:采用定量研究和描述性相关设计,于2021年9月20日至2022年6月30日对AL-Diwaniyah市小学教师进行调查,评估小学教师对注意缺陷多动障碍的认知情况。本研究以354名小学教师为样本。非概率抽样(方便抽样)。样本量的检测采用Steven K. Thompson,(2012)的样本量公式。确定样本大小与总体大小的关系。结果:68.6%的教师对注意缺陷多动障碍有一定的了解(23.90±6.989)。结论:通过对结果的讨论和解释,本研究认为AL-Diwaniyah市小学教师对ADHD的认知处于中等水平。
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引用次数: 0
Preoperative Incentive Spirometer to Prevent Postoperative Pulmonary Complications following Open Heart Surgeries: A Randomized Single Blinded Multi-Centric Clinical Trial 术前激励肺活量计预防心脏直视手术后肺部并发症的随机单盲多中心临床试验
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-08-26 DOI: 10.22317/jcms.v8i4.1261
Jadeel Noor Faleh, S. Al-Fayyadh
Objectives: To determine the effect preoperative use of an Incentive Spirometer (IS) has on preventing postoperative pulmonary complications among patients undergoing open heart surgeries. Methods: A prospective, randomized, controlled single-blinded parallel-group design. Data were collected from January 9th 2022 to April 1st  2022.  A total of n = 64 eligible patients were equally randomized to either intervention or control group. Patients in the intervention group performed preoperative IS training for two days before the scheduled surgery. The primary endpoint was the incidence of in-hospital PPCs. The secondary endpoints were postoperative Peak Expiratory Flow Rate (PEFR), Intensive Care Unit (ICU) stay, Hospital Length of Stay (HLOS). Results: Patients in the intervention group had a lower incidence of postoperative pulmonary complications compared to the control group (12.5% and 21.8%). There was a statistical significant difference between the two groups regarding postoperative PEFR, HLOS and intensive care unit stay. Conclusions: Preoperative rehabilitation (involving incentive spirometer is related to a lower incidence of postoperative pulmonary complications for the group that received the intervention. Training with preoperative incentive spirometer resulted in a shortening of hospital length of stay and Intensive Care Unit (ICU) stay. Trial registration: The study was registered in the Iranian Clinical Trial Registry, this at https://www.irct.ir/ reference number (IRCT20211224053503N1).
目的:确定心脏直视手术患者术前使用激励式肺活量计(IS)预防术后肺部并发症的效果。方法:前瞻性、随机、对照、单盲平行组设计。数据收集时间为2022年1月9日至2022年4月1日。共有64名符合条件的患者被随机分为干预组或对照组。干预组患者在预定手术前进行了为期两天的术前IS训练。主要终点是住院PPCs的发生率。次要终点为术后呼气流速峰值(PEFR)、重症监护室(ICU)住院时间、住院时间(HLOS)。结果:与对照组相比,干预组患者术后肺部并发症的发生率较低(12.5%和21.8%)。两组在术后PEFR、HLOS和重症监护室住院时间方面有统计学意义。结论:术前康复(包括激励性肺活量计)与接受干预组术后肺部并发症的发生率较低有关。术前激励性肺量计训练缩短了住院时间和重症监护室(ICU)的住院时间。试验注册:该研究在伊朗临床试验注册中心注册https://www.irct.ir/参考号(IRCT202111224053503N1)。
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引用次数: 0
Effect of pollution represented by Polycyclic Aromatic Hydrocarbons on the levels of p53 and some antioxidant enzymes in Baghdad traffic police 以多环芳烃为代表的污染对巴格达交警p53和某些抗氧化酶水平的影响
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-08-26 DOI: 10.22317/jcms.v8i4.1254
Ashraf R. Salem, Estabraq A.R. Al-Wasiti, Fahem A. Hasan
Objectives: To ascertain the protective effect of p53 tumor protein by monitoring its levels in comparison with the levels of antioxidant enzymes, against any type of cancer that can be caused by chronic exposure of traffic policemen to air pollutants. Methods: This study comprises 140 participants, who have been divided into two groups (Traffic police and Office police). PAHs were analyzed for each participant by GC/FID while p53 protein and antioxidant enzymes were measured by the ELISA technique.  Results: The concentrations of polycyclic aromatic hydrocarbons and p53 tumor protein were high in the blood of traffic police compared to office police, while higher levels of antioxidant enzymes (Catalase and G-Px) were observed in the blood of office police. Conclusion: Exposure to PAHs can cause oxidative stress, which can damage DNA and lead to cancer. However, because natural endogenous biomolecules like p53 protein can neutralize PAHs' carcinogenic effects, their elevation has a beneficial anti-cancer effect by reducing oxidative stress and preventing tumorigenesis.
目的:通过监测p53肿瘤蛋白水平与抗氧化酶水平的比较,确定其对交通警察长期暴露于空气污染物中可能引起的任何类型癌症的保护作用。方法:本研究将140名被试分为两组(交通警察和办公室警察)。采用气相色谱/FID法分析每个参与者的PAHs, ELISA法检测p53蛋白和抗氧化酶。结果:交警血液中多环芳烃和p53肿瘤蛋白含量高于办公室警察,办公室警察血液中抗氧化酶(过氧化氢酶和G-Px)含量高于办公室警察。结论:接触多环芳烃会引起氧化应激,从而损伤DNA并导致癌症。然而,由于p53蛋白等天然内源性生物分子可以中和PAHs的致癌作用,因此其升高具有减少氧化应激、防止肿瘤发生的有益抗癌作用。
{"title":"Effect of pollution represented by Polycyclic Aromatic Hydrocarbons on the levels of p53 and some antioxidant enzymes in Baghdad traffic police","authors":"Ashraf R. Salem, Estabraq A.R. Al-Wasiti, Fahem A. Hasan","doi":"10.22317/jcms.v8i4.1254","DOIUrl":"https://doi.org/10.22317/jcms.v8i4.1254","url":null,"abstract":"Objectives: To ascertain the protective effect of p53 tumor protein by monitoring its levels in comparison with the levels of antioxidant enzymes, against any type of cancer that can be caused by chronic exposure of traffic policemen to air pollutants. \u0000Methods: This study comprises 140 participants, who have been divided into two groups (Traffic police and Office police). PAHs were analyzed for each participant by GC/FID while p53 protein and antioxidant enzymes were measured by the ELISA technique.  \u0000Results: The concentrations of polycyclic aromatic hydrocarbons and p53 tumor protein were high in the blood of traffic police compared to office police, while higher levels of antioxidant enzymes (Catalase and G-Px) were observed in the blood of office police. \u0000Conclusion: Exposure to PAHs can cause oxidative stress, which can damage DNA and lead to cancer. However, because natural endogenous biomolecules like p53 protein can neutralize PAHs' carcinogenic effects, their elevation has a beneficial anti-cancer effect by reducing oxidative stress and preventing tumorigenesis.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44120303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A study of relationship between SARS-CoV-2 antibodies levels and host factors among general population in Zakho City, Iraq 伊拉克扎霍市普通人群中严重急性呼吸系统综合征冠状病毒2型抗体水平与宿主因素关系的研究
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-08-26 DOI: 10.22317/jcms.v8i4.1256
Nawfal R Hussein, Ibrahim A Naqid, Shakir A Jamal, Amer A. Balatay, Nashwan Ibrahim, Dildar H Musa, Zana S M. Saleem
Objectives: The aim of this cross-sectional study is to evaluate the seroprevalence of total antibodies to SARS-CoV-2 and associated risk factors in Zakho City, Kurdistan Region of Iraq. Methods: This cross-sectional study was performed at Zako City, Northern, Iraq. Blood samples were collected from different districts of Zakho city between January and March 2021. Immunoassays were performed to detect the total antibodies against SARS-CoV-2, and the associations between several variables were investigated. Results: A total of 315 participants were agreed and enrolled in the study. The average age of the participants was 32.87±13.25 years.  Among the participants, 214/315 (67.93%) were found to have antibodies against SARS-CoV-2. Among those who had positive antibodies, 169/214 (78.97%) were asymptomatic and 45/214 (21.03%) had a history of COVID-19 related symptoms. The most common symptom was fever (95.56%), followed by loss of smell (84.44%) and myalgia (80.0%). We found that antibody levels significantly associated with age (P=0.021). The presence of symptoms was significantly higher among subjects with a history of comorbidity diseases (P=0.038), and older people (P = 0.015). A significant association was found between antibody levels and the marital status (P=0.014), chronic diseases (P=0.001), presence (P=0.015) and duration of symptoms (P=0.028). Conclusion: A significant association between antibody levels to SARS-CoV-2 and age, chronic diseases, presence and duration of symptoms were found in this study. Seroprevalence studies of antibodies to SARS-CoV-2 among general population are of utmost importance to develop infection prevention programs in our society.
目的:本横断面研究的目的是评估伊拉克库尔德斯坦地区扎霍市严重急性呼吸系统综合征冠状病毒2型总抗体的血清流行率和相关风险因素。方法:这项横断面研究在伊拉克北部扎科市进行。2021年1月至3月,从扎霍市不同地区采集了血样。进行免疫测定以检测针对严重急性呼吸系统综合征冠状病毒2型的总抗体,并研究了几个变量之间的相关性。结果:共有315名参与者同意并加入该研究。参与者的平均年龄为32.87±13.25岁。在参与者中,214/315人(67.93%)被发现具有针对严重急性呼吸系统综合征冠状病毒2型的抗体。在抗体呈阳性的人中,169/214人(78.97%)无症状,45/214人(21.03%)有新冠肺炎相关症状史。最常见的症状是发烧(95.56%),其次是嗅觉丧失(84.44%)和肌痛(80.0%)。我们发现抗体水平与年龄显著相关(P=0.021)。有合并症病史的受试者症状的出现率显著较高(P=0.038),和老年人(P=0.015)。抗体水平与婚姻状况(P=0.014)、慢性病(P=0.001)、症状存在(P=0.015和持续时间(P=0.028)之间存在显著关联。结论:本研究发现,严重急性呼吸系统综合征冠状病毒2型抗体水平与年龄、慢性病、症状存在和持续时间之间存在显著相关性。对普通人群中严重急性呼吸系统综合征冠状病毒2型抗体的血清流行率研究对于制定我们社会的感染预防计划至关重要。
{"title":"A study of relationship between SARS-CoV-2 antibodies levels and host factors among general population in Zakho City, Iraq","authors":"Nawfal R Hussein, Ibrahim A Naqid, Shakir A Jamal, Amer A. Balatay, Nashwan Ibrahim, Dildar H Musa, Zana S M. Saleem","doi":"10.22317/jcms.v8i4.1256","DOIUrl":"https://doi.org/10.22317/jcms.v8i4.1256","url":null,"abstract":"Objectives: The aim of this cross-sectional study is to evaluate the seroprevalence of total antibodies to SARS-CoV-2 and associated risk factors in Zakho City, Kurdistan Region of Iraq. Methods: This cross-sectional study was performed at Zako City, Northern, Iraq. Blood samples were collected from different districts of Zakho city between January and March 2021. Immunoassays were performed to detect the total antibodies against SARS-CoV-2, and the associations between several variables were investigated. Results: A total of 315 participants were agreed and enrolled in the study. The average age of the participants was 32.87±13.25 years.  Among the participants, 214/315 (67.93%) were found to have antibodies against SARS-CoV-2. Among those who had positive antibodies, 169/214 (78.97%) were asymptomatic and 45/214 (21.03%) had a history of COVID-19 related symptoms. The most common symptom was fever (95.56%), followed by loss of smell (84.44%) and myalgia (80.0%). We found that antibody levels significantly associated with age (P=0.021). The presence of symptoms was significantly higher among subjects with a history of comorbidity diseases (P=0.038), and older people (P = 0.015). A significant association was found between antibody levels and the marital status (P=0.014), chronic diseases (P=0.001), presence (P=0.015) and duration of symptoms (P=0.028). Conclusion: A significant association between antibody levels to SARS-CoV-2 and age, chronic diseases, presence and duration of symptoms were found in this study. Seroprevalence studies of antibodies to SARS-CoV-2 among general population are of utmost importance to develop infection prevention programs in our society.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46790830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
期刊
Journal of Contemporary Medical Sciences
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