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Pheochromocytoma: 16 Years of Experience in a Single Center 嗜铬细胞瘤:在单一中心的16年经验
IF 0.2 Q4 Medicine Pub Date : 2021-01-01 DOI: 10.25179/TJEM.2020-79054
B. Saydam, S. C. Adiyaman, Ozan Bozkurt, O. Demir, M. Koçdor, K. Yörükoğlu, M. Seçil, S. Yener
Division of Endocrinology and Metabolism, Dokuz Eylül University Faculty of Medicine, İzmir, TURKEY *Department of Urology, Dokuz Eylül University Faculty of Medicine, İzmir, TURKEY **Department of General Surgery, Dokuz Eylül University Faculty of Medicine, İzmir, TURKEY ***Department of Pathology, Dokuz Eylül University Faculty of Medicine, İzmir, TURKEY ****Department of Radiology, Dokuz Eylül University Faculty of Medicine, İzmir, TURKEY
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引用次数: 0
Prevalence and Awareness of Hypertension in Seven Distinct Geographic Regions of Turkey: The SEMT HT Study 土耳其七个不同地理区域的高血压患病率和意识:SEMT - HT研究
IF 0.2 Q4 Medicine Pub Date : 2021-01-01 DOI: 10.25179/TJEM.2020-78532
F. Bayram, Ö. Demir, T. Sabuncu, M. A. Eren, Aydın Vedia Gedik, D. Çorapçıoğlu, A. Kaya
Department of Endocrinology, Erciyes University Faculty of Medicine, Kayseri, TURKEY *Department of Endocrinology, Ankara University Faculty of Medicine, Ankara, TURKEY **Department of Endocrinology, Harran University Faculty of Medicine, Şanlıurfa, TURKEY ***Department of Endocrinology, Konya Necmettin Erbakan University Faculty of Medicine, Konya, TURKEY Original Article Turk J Endocrinol Metab. 2021;25:1-10
土耳其开塞利埃尔西耶斯大学医学院内分泌系*土耳其安卡拉安卡拉大学医学院内分泌系**土耳其哈兰大学医学院内分泌系Şanlıurfa ***土耳其科尼亚涅米廷埃尔巴坎大学医学院内分泌系土耳其科尼亚内分泌杂志,2021;25:1-10
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引用次数: 1
Immunohistochemical subtypes of growth hormone-secreted pituitary adenoma and relationship with the clinical course and seconder malignancy 垂体生长激素腺瘤的免疫组织化学亚型及其与临床病程和继发恶性肿瘤的关系
IF 0.2 Q4 Medicine Pub Date : 2020-08-21 DOI: 10.1530/ENDOABS.70.AEP762
Gamze Akkuş, Ralp Cetinalp, E. Bagir, Mehtap Evran, Sinem Sengoz, S. Zorludemir, M. Sert, T. Tetiker
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引用次数: 0
Thrombotic Microangiopathy After Spontaneous Pheochromocytoma Rupture: A Rare MEN 2A Case 自发性嗜铬细胞瘤破裂后的血栓性微血管病变:一例罕见的MEN 2A病例
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2020-74367
İ. Çordan, M. Kocabaş, S. Yılmaz, M. Can, M. Karakose, H. C. Burgucu, M. Kulaksızoğlu, F. Karakurt
Introduction Tumors that originate from chromaffin cells in the adrenal medulla and secrete catecholamine are called pheochromocytoma (1). Catecholamine producing tumors are rare, and their incidence is 2 to 8 cases/million people yearly (2). This disease commonly affects people in their 40s and 50s, but it occurs earlier in people with diseaseassociated germline mutations. Although these tumors are typically sporadic, they are also associated with genetic disorders, including multiple endocrine neoplasia syndrome type 2 (MEN 2). Their symptoms may occur in episodes or paroxysmally and involves a broad clinical spectrum due to the high circulating catecholamine level in plasma. Typical symptoms are tachycardia, pallor, headache, and sweating (3). Hypertension occurs in apPheochromocytoma is an adrenal medulla-derived tumor originating from the chromaffin cells that produce and secrete catecholamines. These tumors usually occur sporadically, but they may also be associated with genetic diseases, such as multiple endocrine neoplasia syndrome type 2 (MEN 2). A hypertensive crisis that occurs after the spontaneous rupture of pheochromocytoma, is a rare clinical complication with a high mortality rate. In this article, we present a male case who developed hypertensive crisis and thrombotic microangiopathy (TMA) after a spontaneous pheochromocytoma rupture due to MEN 2A.
起源于肾上腺髓质中嗜铬细胞并分泌儿茶酚胺的肿瘤称为嗜铬细胞瘤(1)。产生儿茶酚胺的肿瘤很罕见,每年的发病率为2至8例/百万人(2)。这种疾病通常发生在40至50岁的人群中,但在患有疾病相关生殖系突变的人群中发病较早。虽然这些肿瘤通常是散发的,但它们也与遗传性疾病有关,包括多发性内分泌瘤变综合征2型(MEN 2)。它们的症状可能发作或发作,由于血浆中循环儿茶酚胺水平高,涉及广泛的临床范围。典型症状为心动过速、脸色苍白、头痛和出汗(3)。嗜铬细胞瘤是肾上腺髓质源性肿瘤,起源于产生和分泌儿茶酚胺的嗜铬细胞。这些肿瘤通常是零星发生的,但也可能与遗传性疾病有关,如多发性内分泌瘤变综合征2型(MEN 2)。嗜铬细胞瘤自发破裂后出现高血压危象是一种罕见的临床并发症,死亡率很高。在本文中,我们报告了一例男性病例,他在自发性嗜铬细胞瘤破裂后发生高血压危像和血栓性微血管病变(TMA)。
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引用次数: 0
Frequency of Nodular Goiter in Patients with Non-Functional Adrenal Incidentaloma 非功能性肾上腺偶发瘤患者结节性甲状腺肿的发生率
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2020-75427
M. Can, M. Karakose, M. Kocabaş, İ. Çordan, H. C. Burgucu, M. Kulaksızoğlu, F. Karakurt
Objective: Thyroid nodules and metabolic disorders such as obesity, insulin resistance (IR), and dyslipidemia are frequently reported in patients with non-functional adrenal incidentaloma (NFAI). This study aimed to evaluate the structural and functional properties of the thyroid gland and to elucidate whether there is any relationship between these and metabolic parameters in patients with NFAI. Material and Methods: Fifty-four patients diagnosed with NFAI and 54 age, gender, and body mass index (BMI) matched healthy controls were included in the study. Free thyroxine (fT4), thyroid-stimulating hormone (TSH), anti-thyroperoxidase antibody (anti-TPO), fasting blood glucose (FBG), fasting insulin level, lipid profiles, C-reactive protein (CRP) levels were estimated in the patients and controls. Furthermore, patients and controls were evaluated by ultrasonography to determine thyroid structure, thyroid volume, and thyroid nodules. Results: The mean total thyroid volume of the NFAI group (13.48±6.3 mL) was significantly higher as compared to that of the control group (13.13±10 mL) (p<0.001). Thyroid nodules were detected in 18 (33.3%) of 54 subjects in the NFAI group and 16 (29.6%) of 54 subjects in the control group, resulting in an insignificant difference (p = 0.836). However, the average number of thyroid nodules was significantly higher in the NFAI group (1.72) compared to the control group (1.06) (p<0.001). The thyroid nodule size of the NFAI group (17.83±9.01 mm) was also significantly larger than the control group (11.68±4.68 mm) (p=0.017). Moreover, a significant association between the thyroid nodule and TSH (p=0.026) and between thyroid nodule size and adenoma size (p=0.046) in the NFAI group was pronounced. Conclusion: In our study, we found that certain parameters related to the thyroid gland, such as thyroid volumes, average number of thyroid nodules, and thyroid nodule sizes, were significantly higher in NFAI patients than in healthy controls. There was no significant difference in terms of thyroid functions and thyroid nodule frequency. In this regard, studies with larger sample size, encompassing all factors that may affect thyroid structure and functions, are essential.
目的:甲状腺结节和代谢紊乱(如肥胖、胰岛素抵抗(IR)和血脂异常)在非功能性肾上腺偶发瘤(NFAI)患者中经常被报道。本研究旨在评估甲状腺的结构和功能特性,并阐明这些特性与NFAI患者的代谢参数之间是否存在任何关系。材料和方法:54例诊断为NFAI的患者,年龄、性别和体重指数(BMI)与健康对照相匹配,纳入研究。评估患者和对照组的游离甲状腺素(fT4)、促甲状腺激素(TSH)、抗甲状腺过氧化物酶抗体(anti-TPO)、空腹血糖(FBG)、空腹胰岛素水平、血脂、c反应蛋白(CRP)水平。此外,对患者和对照组进行超声检查,以确定甲状腺结构、甲状腺体积和甲状腺结节。结果:NFAI组平均甲状腺总容积(13.48±6.3 mL)显著高于对照组(13.13±10 mL) (p<0.001)。NFAI组54例患者中有18例(33.3%)检出甲状腺结节,对照组54例中有16例(29.6%)检出甲状腺结节,差异无统计学意义(p = 0.836)。然而,NFAI组甲状腺结节的平均数量(1.72)明显高于对照组(1.06)(p<0.001)。NFAI组甲状腺结节大小(17.83±9.01 mm)也显著大于对照组(11.68±4.68 mm) (p=0.017)。此外,NFAI组甲状腺结节与TSH (p=0.026)、甲状腺结节大小与腺瘤大小(p=0.046)显著相关。结论:在我们的研究中,我们发现NFAI患者与甲状腺相关的某些参数,如甲状腺体积、甲状腺结节的平均数量和甲状腺结节的大小,明显高于健康对照组。两组在甲状腺功能和甲状腺结节频率方面无显著差异。在这方面,研究更大的样本量,包括所有可能影响甲状腺结构和功能的因素,是必不可少的。
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引用次数: 0
Scientific Performance in Endocrinology and Metabolism Over the Past 45 Years: A Scientometrics Study in the Middle-East Countries 在过去的45年里,内分泌学和代谢学的科学表现:中东国家的科学计量学研究
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2019-72325
H. Ramezani, Nahid Hashemimadani, Z. Emami, Razieh Shahrokhi-Farid, F. Golgiri, M. Khamseh
Objective: This study aimed to explore the scientific performance in research of endocrinology and metabolism and its correlation with the socioeconomic indicators in the MiddleEast countries. Material and Methods: Scientometrics and social network analysis methods were used for this study. Data were extracted from the Web of Science, World Bank, and UIS data center of UNESCO. Results: The majority of scientific productions (79.6%) were published by authors affiliated with upper-middle and high income countries which includes Turkey, Israel, and Iran. From co-authorship analysis, Saudi Arabia, Egypt, and Turkey with most degree centrality, had the highest collaborative ranking with other Middle-East countries. The main Middle-East collaborators having scientific outputs in this field were the researchers from the USA, England, and Germany. Israel, Turkey, and Saudi Arabia had the most collaboration (63.8%) with other countries. Also, there was a strong positive correlation between total collaborations with global countries and the number of citations. Conclusion: Due to the correlation among scientific productions, citations, scientific collaborations, Gross domestic expenditure on research and development, and specialist human resources indicators, the supplementary budget should be directed toward research in the Middle-East countries and establishing global networks to conduct joint projects. This could increase the trend of scientific productions and obtain higher citations in the Web of Science, eventually leading to scientific, social as well as economic development in the region.
目的:本研究旨在探讨中东国家内分泌代谢研究的科学表现及其与社会经济指标的相关性。材料与方法:本研究采用科学计量学和社会网络分析方法。数据摘自科学网、世界银行和联合国教科文组织美国数据中心。结果:绝大多数科学成果(79.6%)由中高收入国家的作者发表,这些国家包括土耳其、以色列和伊朗。从合作作者分析来看,沙特阿拉伯、埃及和土耳其的学位中心性最高,与其他中东国家的合作排名最高。在这一领域有科学成果的主要中东合作者是来自美国、英国和德国的研究人员。与其他国家合作最多的是以色列、土耳其和沙特阿拉伯(63.8%)。此外,与全球国家的合作总量与引用次数之间存在很强的正相关关系。结论:由于科学产出、引文、科学合作、国内研究与开发总支出和专业人力资源指标之间的相关性,补充预算应针对中东国家的研究和建立开展联合项目的全球网络。这可能会增加科学产出的趋势,并在Web of Science中获得更高的引用,最终促进该地区的科学、社会和经济发展。
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引用次数: 1
Effect of Vitamin D Deficiency on the Frequency of Lipohypertrophy Occurrence in Patients with Type 2 Diabetes Mellitus Under Injectable Treatment 维生素D缺乏对注射治疗2型糖尿病患者脂肪肥大发生频率的影响
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2020-74469
C. O. Kıraç, Cuma Gönüllü, S. Baldane, L. Kebapçılar
Objective: Lipohypertrophy (LH) is one of the most common treatment-related cutaneous complications of injectable therapies. Although the etiology of LH cannot be clarified, it may be due to the lipogenic effect of insulin or recurrent tissue trauma caused by injections. In this respect, we aimed to evaluate the relationship between vitamin D level and LH. Material and Methods: Patients with Type 2 diabetes mellitus aged 18 years or older, who were under insulin and/or exenatide treatment for at least one year were included in this study. The injection sites of the patients were examined by inspection and palpation method. Patients were categorized into two groups according to vitamin D levels as below and above 20 ng/mL. Results: A total of 140 patients, including 91 women and 49 men, aged between 20-78 years with a mean age of 54.53±13.89 were included in the study. LH was detected in 91 (65%) of 140 patients. This study demonstrated that there was a significant relationship between gender and LH. Statistically, the frequency of LH was higher in female patients (p=0.001). Further, a relationship between vitamin D levels and LH was also observed (p=0.006). Conclusion: Besides calcium metabolism, the effects of vitamin D on lipogenesis are also known. Vitamin D inhibits the differentiation of pre-adipocytes to mature adipocytes. This is the first study showing the relationship between vitamin D and LH in our knowledge.
目的:脂肪肥大(LH)是注射治疗中最常见的皮肤并发症之一。虽然LH的病因尚不清楚,但可能与胰岛素的致脂作用或注射引起的复发性组织损伤有关。在这方面,我们旨在评估维生素D水平与LH之间的关系。材料和方法:年龄在18岁或以上,接受胰岛素和/或艾塞那肽治疗至少一年的2型糖尿病患者纳入本研究。采用检查法和触诊法对患者的注射部位进行检查。根据维生素D水平将患者分为低于和高于20 ng/mL两组。结果:共纳入140例患者,其中女性91例,男性49例,年龄20 ~ 78岁,平均年龄54.53±13.89岁。140例患者中有91例(65%)检测到LH。本研究表明,性别与LH有显著相关。LH在女性患者中出现的频率较高(p=0.001)。此外,还观察到维生素D水平与LH之间的关系(p=0.006)。结论:除了钙代谢外,维生素D对脂肪生成的影响也是已知的。维生素D抑制前脂肪细胞向成熟脂肪细胞的分化。这是我们所知的第一个显示维生素D和黄体生成素之间关系的研究。
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引用次数: 1
Dealing with COVID-19: Through Endocrinologist’s Eyes 应对COVID-19:通过内分泌学家的眼睛
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2020-78280
C. Sulu, P. Kadioglu
Less than a year ago, none of us had heard of novel coronavirus disease (COVID-19) Today, it has become the main topic of our daily conversations This disastrous disease has united the medical professions belonging to various specialties to fight against the disease in collaboration However, the exact role of endocrinologists still remains elusive The coronavirus could potentially infect organs other than the lungs, such as the pancreas, thyroid, adrenal glands, and pituitary, as reflected by various endocrinological manifestations The direct invasion of organ systems and indirect mechanisms such as induction of autoimmunity could be responsible for the endocrinological consequences A large body of literature on its pathophysiology, management, and associated conditions is growing, and its association with endocrinological diseases is increasingly being recognized However, data that would guide the proper management of these endocrinological disorders during this novel pandemic are still lacking This review presented a brief overview of the association of COVID-19 with endocrinological diseases and methods to ease the management of some frequently encountered endocrinological problems
不到一年前,我们都没有听说过新型冠状病毒病(COVID-19),今天,它已经成为我们日常对话的主要话题。这种灾难性的疾病使各个专业的医疗专业团结起来,共同对抗这种疾病。然而,内分泌学家的确切作用仍然难以确定。冠状病毒可能感染肺部以外的器官,如胰腺、甲状腺、肾上腺和垂体。直接侵入器官系统和间接机制(如诱导自身免疫)可能是导致内分泌后果的原因,关于其病理生理学、治疗和相关条件的大量文献正在增加,其与内分泌疾病的关联也越来越被认识到。这篇综述简要概述了COVID-19与内分泌疾病的关系,以及缓解一些常见内分泌问题管理的方法
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引用次数: 0
The Relationship Between TSH Level and Stage of Differentiated Thyroid Carcinoma TSH水平与分化型甲状腺癌分期的关系
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2020-74747
Esra Tunçez, M. Kulaksızoğlu, I. Tuncez
Objective: The aim of this study was to determine whether thyroid-stimulating hormone (TSH) levels during the diagnosis of patients with differentiated thyroid carcinoma could be used for the prediction of cancer behavior. Material and Methods: The records of 329 patients with differentiated thyroid carcinoma who did not use levothyroxine at the time of diagnosis were reviewed retrospectively. The demographic and clinical characteristics of the cases and serum TSH levels were recorded at the time of diagnosis and statistically analyzed. Results: A total of 329 cases with 322 papillary carcinomas and 7 follicular carcinomas were included in the study. The median age of the participants at the time of diagnosis was 45 (17-76) years. Eighty-three percent of the cases were diagnosed in stage 1, 6.7% in stage 2, 3.3% in stage 3, and 7.0% in stage 4. The median serum TSH level at the time of diagnosis of the cases was 1.34 (0.019.97) mIU/mL. We did not observe any statistically significant relationship between the serum TSH level and the stage of differentiated thyroid carcinoma, although higher serum TSH level was associated with lymph node metastasis and higher risk group in the American Thyroid Association (ATA) classification. Conclusion: The relationship between serum TSH level and thyroid cancer has not been clearly determined, but high TSH levels at the time of diagnosis were found to be associated with lymph node metastasis and medium-high ATA risk score.
目的:本研究旨在探讨分化型甲状腺癌诊断过程中促甲状腺激素(TSH)水平是否可用于癌行为的预测。材料与方法:回顾性分析329例诊断时未使用左旋甲状腺素的分化型甲状腺癌患者的资料。记录病例的人口学、临床特征及诊断时血清TSH水平,并进行统计学分析。结果:共纳入329例,其中乳头状癌322例,滤泡癌7例。诊断时参与者的中位年龄为45岁(17-76岁)。1期占83%,2期为6.7%,3期为3.3%,4期为7.0%。诊断时血清TSH水平中位数为1.34 (0.019.97)mIU/mL。我们没有观察到血清TSH水平与分化型甲状腺癌分期之间有统计学意义的关系,尽管在美国甲状腺协会(ATA)分类中,较高的血清TSH水平与淋巴结转移和高危组相关。结论:血清TSH水平与甲状腺癌的关系尚未明确,但诊断时高TSH水平与淋巴结转移和中高ATA危险评分相关。
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引用次数: 0
Association of Serum Resistin Level and Resistin (RETN) Gene (-420C>G) Polymorphism in Pakistani Women with Polycystic Ovarian Syndrome 巴基斯坦多囊卵巢综合征妇女血清抵抗素水平与抵抗素(RETN)基因(-420C>G)多态性的关系
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2019-66784
Yasar Nawaz, Sumbla Ghazanvi, Nadia Rasheed, S. Jahan, M. I. Ullah
Objective: The objective of the present study was to investigate the association of altered serum resistin levels to RETN gene (420C>G) polymorphism in women with polycystic ovarian syndrome (PCOS) and in healthy controls. Material and Methods: Eighty (40 PCOS cases and 40 healthy controls) individuals were included. Whole blood and serum samples were taken from all participants. Enzyme linked immunosorbent (ELISA) was performed for measuring the levels of serum resistin. Whole blood was used for extracting total genomic DNA by the phenol-chloroform method. Polymerase chain reaction with fragment length polymorphism was performed for detecting single nucleotide polymorphism (SNP) in the promoter region (-420 C>G) of the resistin (RETN) gene by amplifying the oligonucleotide sequence of the SNP. The amplified products were first confirmed on 2.0% agarose gel for product size, and then restriction digestion of these products was performed by using the Bpil restriction enzyme. After completion of digestion, the products were resolved on 2.5% agarose gel with a 100 bp DNA ladder, and the bands were inspected to infer genotype. Data analysis was done using SPSS software and the association between serum resistin levels and RETN genotypes was analyzed. Results: There was no significant difference (p=0.125) observed in serum resistin levels between PCOS cases (mean±SD=19.33±3.50) and healthy controls (mean±SD= 13.48±1.31). The frequency of the G allele was high in PCOS cases (65%) than in controls (53.7%). The GG genotype frequency of SNP (-420 C>G) was high in PCOS cases (40%) than in controls (20%), but no association was found (p=0.148). The high serum resistin levels were significantly associated with the GG genotype in PCOS cases (p=0.027). Conclusion: High serum resistin levels are not associated with the genotypes of RETN (-420 C>G) polymorphism in PCOS women and controls, although women with PCOS had high GG genotype levels of serum resistin. Further studies with large sample size should be conducted to explore the mechanism of genetic factors in complex diseases like PCOS.
目的:探讨多囊卵巢综合征(PCOS)女性和健康对照者血清抵抗素水平改变与RETN基因(420C>G)多态性的关系。材料与方法:纳入80例(PCOS患者40例,健康对照40例)。采集所有参与者的全血和血清样本。采用酶联免疫吸附法(ELISA)测定血清抵抗素水平。全血采用酚-氯仿法提取基因组总DNA。采用片段长度多态性聚合酶链反应,通过扩增抵抗素(RETN)基因启动子区(-420 C>G)单核苷酸多态性(SNP)的寡核苷酸序列,检测其多态性。扩增产物先在2.0%琼脂糖凝胶上确定产物大小,然后用Bpil酶切酶对扩增产物进行酶切。消化完成后,在2.5%琼脂糖凝胶上用100 bp的DNA阶梯进行溶解,检查条带以推断基因型。采用SPSS软件进行数据分析,分析血清抵抗素水平与RETN基因型的相关性。结果:PCOS患者血清抵抗素水平(平均±SD=19.33±3.50)与健康对照组(平均±SD= 13.48±1.31)差异无统计学意义(p=0.125)。PCOS患者G等位基因频率(65%)高于对照组(53.7%)。PCOS患者GG基因型SNP (-420 C>G)频率(40%)高于对照组(20%),但无相关性(p=0.148)。PCOS患者血清抵抗素水平与GG基因型显著相关(p=0.027)。结论:PCOS患者血清抵抗素高水平与RETN基因型(-420 C>G)多态性无关,但PCOS患者血清抵抗素GG基因型较高。遗传因素在多囊卵巢综合征等复杂疾病中的作用机制有待进一步大样本研究。
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引用次数: 3
期刊
Turkish Journal of Endocrinology and Metabolism
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