Pub Date : 2021-01-01DOI: 10.25179/TJEM.2020-79054
B. Saydam, S. C. Adiyaman, Ozan Bozkurt, O. Demir, M. Koçdor, K. Yörükoğlu, M. Seçil, S. Yener
Division of Endocrinology and Metabolism, Dokuz Eylül University Faculty of Medicine, İzmir, TURKEY *Department of Urology, Dokuz Eylül University Faculty of Medicine, İzmir, TURKEY **Department of General Surgery, Dokuz Eylül University Faculty of Medicine, İzmir, TURKEY ***Department of Pathology, Dokuz Eylül University Faculty of Medicine, İzmir, TURKEY ****Department of Radiology, Dokuz Eylül University Faculty of Medicine, İzmir, TURKEY
{"title":"Pheochromocytoma: 16 Years of Experience in a Single Center","authors":"B. Saydam, S. C. Adiyaman, Ozan Bozkurt, O. Demir, M. Koçdor, K. Yörükoğlu, M. Seçil, S. Yener","doi":"10.25179/TJEM.2020-79054","DOIUrl":"https://doi.org/10.25179/TJEM.2020-79054","url":null,"abstract":"Division of Endocrinology and Metabolism, Dokuz Eylül University Faculty of Medicine, İzmir, TURKEY *Department of Urology, Dokuz Eylül University Faculty of Medicine, İzmir, TURKEY **Department of General Surgery, Dokuz Eylül University Faculty of Medicine, İzmir, TURKEY ***Department of Pathology, Dokuz Eylül University Faculty of Medicine, İzmir, TURKEY ****Department of Radiology, Dokuz Eylül University Faculty of Medicine, İzmir, TURKEY","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"114 1","pages":"54-67"},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75650096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.25179/TJEM.2020-78532
F. Bayram, Ö. Demir, T. Sabuncu, M. A. Eren, Aydın Vedia Gedik, D. Çorapçıoğlu, A. Kaya
Department of Endocrinology, Erciyes University Faculty of Medicine, Kayseri, TURKEY *Department of Endocrinology, Ankara University Faculty of Medicine, Ankara, TURKEY **Department of Endocrinology, Harran University Faculty of Medicine, Şanlıurfa, TURKEY ***Department of Endocrinology, Konya Necmettin Erbakan University Faculty of Medicine, Konya, TURKEY Original Article Turk J Endocrinol Metab. 2021;25:1-10
{"title":"Prevalence and Awareness of Hypertension in Seven Distinct Geographic Regions of Turkey: The SEMT HT Study","authors":"F. Bayram, Ö. Demir, T. Sabuncu, M. A. Eren, Aydın Vedia Gedik, D. Çorapçıoğlu, A. Kaya","doi":"10.25179/TJEM.2020-78532","DOIUrl":"https://doi.org/10.25179/TJEM.2020-78532","url":null,"abstract":"Department of Endocrinology, Erciyes University Faculty of Medicine, Kayseri, TURKEY *Department of Endocrinology, Ankara University Faculty of Medicine, Ankara, TURKEY **Department of Endocrinology, Harran University Faculty of Medicine, Şanlıurfa, TURKEY ***Department of Endocrinology, Konya Necmettin Erbakan University Faculty of Medicine, Konya, TURKEY Original Article Turk J Endocrinol Metab. 2021;25:1-10","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"94 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74342899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-21DOI: 10.1530/ENDOABS.70.AEP762
Gamze Akkuş, Ralp Cetinalp, E. Bagir, Mehtap Evran, Sinem Sengoz, S. Zorludemir, M. Sert, T. Tetiker
{"title":"Immunohistochemical subtypes of growth hormone-secreted pituitary adenoma and relationship with the clinical course and seconder malignancy","authors":"Gamze Akkuş, Ralp Cetinalp, E. Bagir, Mehtap Evran, Sinem Sengoz, S. Zorludemir, M. Sert, T. Tetiker","doi":"10.1530/ENDOABS.70.AEP762","DOIUrl":"https://doi.org/10.1530/ENDOABS.70.AEP762","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"8 1","pages":"63-71"},"PeriodicalIF":0.2,"publicationDate":"2020-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75432283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.25179/tjem.2020-74367
İ. Çordan, M. Kocabaş, S. Yılmaz, M. Can, M. Karakose, H. C. Burgucu, M. Kulaksızoğlu, F. Karakurt
Introduction Tumors that originate from chromaffin cells in the adrenal medulla and secrete catecholamine are called pheochromocytoma (1). Catecholamine producing tumors are rare, and their incidence is 2 to 8 cases/million people yearly (2). This disease commonly affects people in their 40s and 50s, but it occurs earlier in people with diseaseassociated germline mutations. Although these tumors are typically sporadic, they are also associated with genetic disorders, including multiple endocrine neoplasia syndrome type 2 (MEN 2). Their symptoms may occur in episodes or paroxysmally and involves a broad clinical spectrum due to the high circulating catecholamine level in plasma. Typical symptoms are tachycardia, pallor, headache, and sweating (3). Hypertension occurs in apPheochromocytoma is an adrenal medulla-derived tumor originating from the chromaffin cells that produce and secrete catecholamines. These tumors usually occur sporadically, but they may also be associated with genetic diseases, such as multiple endocrine neoplasia syndrome type 2 (MEN 2). A hypertensive crisis that occurs after the spontaneous rupture of pheochromocytoma, is a rare clinical complication with a high mortality rate. In this article, we present a male case who developed hypertensive crisis and thrombotic microangiopathy (TMA) after a spontaneous pheochromocytoma rupture due to MEN 2A.
{"title":"Thrombotic Microangiopathy After Spontaneous Pheochromocytoma Rupture: A Rare MEN 2A Case","authors":"İ. Çordan, M. Kocabaş, S. Yılmaz, M. Can, M. Karakose, H. C. Burgucu, M. Kulaksızoğlu, F. Karakurt","doi":"10.25179/tjem.2020-74367","DOIUrl":"https://doi.org/10.25179/tjem.2020-74367","url":null,"abstract":"Introduction Tumors that originate from chromaffin cells in the adrenal medulla and secrete catecholamine are called pheochromocytoma (1). Catecholamine producing tumors are rare, and their incidence is 2 to 8 cases/million people yearly (2). This disease commonly affects people in their 40s and 50s, but it occurs earlier in people with diseaseassociated germline mutations. Although these tumors are typically sporadic, they are also associated with genetic disorders, including multiple endocrine neoplasia syndrome type 2 (MEN 2). Their symptoms may occur in episodes or paroxysmally and involves a broad clinical spectrum due to the high circulating catecholamine level in plasma. Typical symptoms are tachycardia, pallor, headache, and sweating (3). Hypertension occurs in apPheochromocytoma is an adrenal medulla-derived tumor originating from the chromaffin cells that produce and secrete catecholamines. These tumors usually occur sporadically, but they may also be associated with genetic diseases, such as multiple endocrine neoplasia syndrome type 2 (MEN 2). A hypertensive crisis that occurs after the spontaneous rupture of pheochromocytoma, is a rare clinical complication with a high mortality rate. In this article, we present a male case who developed hypertensive crisis and thrombotic microangiopathy (TMA) after a spontaneous pheochromocytoma rupture due to MEN 2A.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"112 1","pages":"247-252"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80676996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.25179/tjem.2020-75427
M. Can, M. Karakose, M. Kocabaş, İ. Çordan, H. C. Burgucu, M. Kulaksızoğlu, F. Karakurt
Objective: Thyroid nodules and metabolic disorders such as obesity, insulin resistance (IR), and dyslipidemia are frequently reported in patients with non-functional adrenal incidentaloma (NFAI). This study aimed to evaluate the structural and functional properties of the thyroid gland and to elucidate whether there is any relationship between these and metabolic parameters in patients with NFAI. Material and Methods: Fifty-four patients diagnosed with NFAI and 54 age, gender, and body mass index (BMI) matched healthy controls were included in the study. Free thyroxine (fT4), thyroid-stimulating hormone (TSH), anti-thyroperoxidase antibody (anti-TPO), fasting blood glucose (FBG), fasting insulin level, lipid profiles, C-reactive protein (CRP) levels were estimated in the patients and controls. Furthermore, patients and controls were evaluated by ultrasonography to determine thyroid structure, thyroid volume, and thyroid nodules. Results: The mean total thyroid volume of the NFAI group (13.48±6.3 mL) was significantly higher as compared to that of the control group (13.13±10 mL) (p<0.001). Thyroid nodules were detected in 18 (33.3%) of 54 subjects in the NFAI group and 16 (29.6%) of 54 subjects in the control group, resulting in an insignificant difference (p = 0.836). However, the average number of thyroid nodules was significantly higher in the NFAI group (1.72) compared to the control group (1.06) (p<0.001). The thyroid nodule size of the NFAI group (17.83±9.01 mm) was also significantly larger than the control group (11.68±4.68 mm) (p=0.017). Moreover, a significant association between the thyroid nodule and TSH (p=0.026) and between thyroid nodule size and adenoma size (p=0.046) in the NFAI group was pronounced. Conclusion: In our study, we found that certain parameters related to the thyroid gland, such as thyroid volumes, average number of thyroid nodules, and thyroid nodule sizes, were significantly higher in NFAI patients than in healthy controls. There was no significant difference in terms of thyroid functions and thyroid nodule frequency. In this regard, studies with larger sample size, encompassing all factors that may affect thyroid structure and functions, are essential.
{"title":"Frequency of Nodular Goiter in Patients with Non-Functional Adrenal Incidentaloma","authors":"M. Can, M. Karakose, M. Kocabaş, İ. Çordan, H. C. Burgucu, M. Kulaksızoğlu, F. Karakurt","doi":"10.25179/tjem.2020-75427","DOIUrl":"https://doi.org/10.25179/tjem.2020-75427","url":null,"abstract":"Objective: Thyroid nodules and metabolic disorders such as obesity, insulin resistance (IR), and dyslipidemia are frequently reported in patients with non-functional adrenal incidentaloma (NFAI). This study aimed to evaluate the structural and functional properties of the thyroid gland and to elucidate whether there is any relationship between these and metabolic parameters in patients with NFAI. Material and Methods: Fifty-four patients diagnosed with NFAI and 54 age, gender, and body mass index (BMI) matched healthy controls were included in the study. Free thyroxine (fT4), thyroid-stimulating hormone (TSH), anti-thyroperoxidase antibody (anti-TPO), fasting blood glucose (FBG), fasting insulin level, lipid profiles, C-reactive protein (CRP) levels were estimated in the patients and controls. Furthermore, patients and controls were evaluated by ultrasonography to determine thyroid structure, thyroid volume, and thyroid nodules. Results: The mean total thyroid volume of the NFAI group (13.48±6.3 mL) was significantly higher as compared to that of the control group (13.13±10 mL) (p<0.001). Thyroid nodules were detected in 18 (33.3%) of 54 subjects in the NFAI group and 16 (29.6%) of 54 subjects in the control group, resulting in an insignificant difference (p = 0.836). However, the average number of thyroid nodules was significantly higher in the NFAI group (1.72) compared to the control group (1.06) (p<0.001). The thyroid nodule size of the NFAI group (17.83±9.01 mm) was also significantly larger than the control group (11.68±4.68 mm) (p=0.017). Moreover, a significant association between the thyroid nodule and TSH (p=0.026) and between thyroid nodule size and adenoma size (p=0.046) in the NFAI group was pronounced. Conclusion: In our study, we found that certain parameters related to the thyroid gland, such as thyroid volumes, average number of thyroid nodules, and thyroid nodule sizes, were significantly higher in NFAI patients than in healthy controls. There was no significant difference in terms of thyroid functions and thyroid nodule frequency. In this regard, studies with larger sample size, encompassing all factors that may affect thyroid structure and functions, are essential.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"1 1","pages":"270-276"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89801877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.25179/tjem.2019-72325
H. Ramezani, Nahid Hashemimadani, Z. Emami, Razieh Shahrokhi-Farid, F. Golgiri, M. Khamseh
Objective: This study aimed to explore the scientific performance in research of endocrinology and metabolism and its correlation with the socioeconomic indicators in the MiddleEast countries. Material and Methods: Scientometrics and social network analysis methods were used for this study. Data were extracted from the Web of Science, World Bank, and UIS data center of UNESCO. Results: The majority of scientific productions (79.6%) were published by authors affiliated with upper-middle and high income countries which includes Turkey, Israel, and Iran. From co-authorship analysis, Saudi Arabia, Egypt, and Turkey with most degree centrality, had the highest collaborative ranking with other Middle-East countries. The main Middle-East collaborators having scientific outputs in this field were the researchers from the USA, England, and Germany. Israel, Turkey, and Saudi Arabia had the most collaboration (63.8%) with other countries. Also, there was a strong positive correlation between total collaborations with global countries and the number of citations. Conclusion: Due to the correlation among scientific productions, citations, scientific collaborations, Gross domestic expenditure on research and development, and specialist human resources indicators, the supplementary budget should be directed toward research in the Middle-East countries and establishing global networks to conduct joint projects. This could increase the trend of scientific productions and obtain higher citations in the Web of Science, eventually leading to scientific, social as well as economic development in the region.
目的:本研究旨在探讨中东国家内分泌代谢研究的科学表现及其与社会经济指标的相关性。材料与方法:本研究采用科学计量学和社会网络分析方法。数据摘自科学网、世界银行和联合国教科文组织美国数据中心。结果:绝大多数科学成果(79.6%)由中高收入国家的作者发表，这些国家包括土耳其、以色列和伊朗。从合作作者分析来看，沙特阿拉伯、埃及和土耳其的学位中心性最高，与其他中东国家的合作排名最高。在这一领域有科学成果的主要中东合作者是来自美国、英国和德国的研究人员。与其他国家合作最多的是以色列、土耳其和沙特阿拉伯(63.8%)。此外，与全球国家的合作总量与引用次数之间存在很强的正相关关系。结论:由于科学产出、引文、科学合作、国内研究与开发总支出和专业人力资源指标之间的相关性，补充预算应针对中东国家的研究和建立开展联合项目的全球网络。这可能会增加科学产出的趋势，并在Web of Science中获得更高的引用，最终促进该地区的科学、社会和经济发展。
{"title":"Scientific Performance in Endocrinology and Metabolism Over the Past 45 Years: A Scientometrics Study in the Middle-East Countries","authors":"H. Ramezani, Nahid Hashemimadani, Z. Emami, Razieh Shahrokhi-Farid, F. Golgiri, M. Khamseh","doi":"10.25179/tjem.2019-72325","DOIUrl":"https://doi.org/10.25179/tjem.2019-72325","url":null,"abstract":"Objective: This study aimed to explore the scientific performance in research of endocrinology and metabolism and its correlation with the socioeconomic indicators in the MiddleEast countries. Material and Methods: Scientometrics and social network analysis methods were used for this study. Data were extracted from the Web of Science, World Bank, and UIS data center of UNESCO. Results: The majority of scientific productions (79.6%) were published by authors affiliated with upper-middle and high income countries which includes Turkey, Israel, and Iran. From co-authorship analysis, Saudi Arabia, Egypt, and Turkey with most degree centrality, had the highest collaborative ranking with other Middle-East countries. The main Middle-East collaborators having scientific outputs in this field were the researchers from the USA, England, and Germany. Israel, Turkey, and Saudi Arabia had the most collaboration (63.8%) with other countries. Also, there was a strong positive correlation between total collaborations with global countries and the number of citations. Conclusion: Due to the correlation among scientific productions, citations, scientific collaborations, Gross domestic expenditure on research and development, and specialist human resources indicators, the supplementary budget should be directed toward research in the Middle-East countries and establishing global networks to conduct joint projects. This could increase the trend of scientific productions and obtain higher citations in the Web of Science, eventually leading to scientific, social as well as economic development in the region.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"87 1","pages":"149-162"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75421038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.25179/tjem.2020-74469
C. O. Kıraç, Cuma Gönüllü, S. Baldane, L. Kebapçılar
Objective: Lipohypertrophy (LH) is one of the most common treatment-related cutaneous complications of injectable therapies. Although the etiology of LH cannot be clarified, it may be due to the lipogenic effect of insulin or recurrent tissue trauma caused by injections. In this respect, we aimed to evaluate the relationship between vitamin D level and LH. Material and Methods: Patients with Type 2 diabetes mellitus aged 18 years or older, who were under insulin and/or exenatide treatment for at least one year were included in this study. The injection sites of the patients were examined by inspection and palpation method. Patients were categorized into two groups according to vitamin D levels as below and above 20 ng/mL. Results: A total of 140 patients, including 91 women and 49 men, aged between 20-78 years with a mean age of 54.53±13.89 were included in the study. LH was detected in 91 (65%) of 140 patients. This study demonstrated that there was a significant relationship between gender and LH. Statistically, the frequency of LH was higher in female patients (p=0.001). Further, a relationship between vitamin D levels and LH was also observed (p=0.006). Conclusion: Besides calcium metabolism, the effects of vitamin D on lipogenesis are also known. Vitamin D inhibits the differentiation of pre-adipocytes to mature adipocytes. This is the first study showing the relationship between vitamin D and LH in our knowledge.
{"title":"Effect of Vitamin D Deficiency on the Frequency of Lipohypertrophy Occurrence in Patients with Type 2 Diabetes Mellitus Under Injectable Treatment","authors":"C. O. Kıraç, Cuma Gönüllü, S. Baldane, L. Kebapçılar","doi":"10.25179/tjem.2020-74469","DOIUrl":"https://doi.org/10.25179/tjem.2020-74469","url":null,"abstract":"Objective: Lipohypertrophy (LH) is one of the most common treatment-related cutaneous complications of injectable therapies. Although the etiology of LH cannot be clarified, it may be due to the lipogenic effect of insulin or recurrent tissue trauma caused by injections. In this respect, we aimed to evaluate the relationship between vitamin D level and LH. Material and Methods: Patients with Type 2 diabetes mellitus aged 18 years or older, who were under insulin and/or exenatide treatment for at least one year were included in this study. The injection sites of the patients were examined by inspection and palpation method. Patients were categorized into two groups according to vitamin D levels as below and above 20 ng/mL. Results: A total of 140 patients, including 91 women and 49 men, aged between 20-78 years with a mean age of 54.53±13.89 were included in the study. LH was detected in 91 (65%) of 140 patients. This study demonstrated that there was a significant relationship between gender and LH. Statistically, the frequency of LH was higher in female patients (p=0.001). Further, a relationship between vitamin D levels and LH was also observed (p=0.006). Conclusion: Besides calcium metabolism, the effects of vitamin D on lipogenesis are also known. Vitamin D inhibits the differentiation of pre-adipocytes to mature adipocytes. This is the first study showing the relationship between vitamin D and LH in our knowledge.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"4 1","pages":"184-188"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74095721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.25179/tjem.2020-78280
C. Sulu, P. Kadioglu
Less than a year ago, none of us had heard of novel coronavirus disease (COVID-19) Today, it has become the main topic of our daily conversations This disastrous disease has united the medical professions belonging to various specialties to fight against the disease in collaboration However, the exact role of endocrinologists still remains elusive The coronavirus could potentially infect organs other than the lungs, such as the pancreas, thyroid, adrenal glands, and pituitary, as reflected by various endocrinological manifestations The direct invasion of organ systems and indirect mechanisms such as induction of autoimmunity could be responsible for the endocrinological consequences A large body of literature on its pathophysiology, management, and associated conditions is growing, and its association with endocrinological diseases is increasingly being recognized However, data that would guide the proper management of these endocrinological disorders during this novel pandemic are still lacking This review presented a brief overview of the association of COVID-19 with endocrinological diseases and methods to ease the management of some frequently encountered endocrinological problems
{"title":"Dealing with COVID-19: Through Endocrinologist’s Eyes","authors":"C. Sulu, P. Kadioglu","doi":"10.25179/tjem.2020-78280","DOIUrl":"https://doi.org/10.25179/tjem.2020-78280","url":null,"abstract":"Less than a year ago, none of us had heard of novel coronavirus disease (COVID-19) Today, it has become the main topic of our daily conversations This disastrous disease has united the medical professions belonging to various specialties to fight against the disease in collaboration However, the exact role of endocrinologists still remains elusive The coronavirus could potentially infect organs other than the lungs, such as the pancreas, thyroid, adrenal glands, and pituitary, as reflected by various endocrinological manifestations The direct invasion of organ systems and indirect mechanisms such as induction of autoimmunity could be responsible for the endocrinological consequences A large body of literature on its pathophysiology, management, and associated conditions is growing, and its association with endocrinological diseases is increasingly being recognized However, data that would guide the proper management of these endocrinological disorders during this novel pandemic are still lacking This review presented a brief overview of the association of COVID-19 with endocrinological diseases and methods to ease the management of some frequently encountered endocrinological problems","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89170989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.25179/tjem.2020-74747
Esra Tunçez, M. Kulaksızoğlu, I. Tuncez
Objective: The aim of this study was to determine whether thyroid-stimulating hormone (TSH) levels during the diagnosis of patients with differentiated thyroid carcinoma could be used for the prediction of cancer behavior. Material and Methods: The records of 329 patients with differentiated thyroid carcinoma who did not use levothyroxine at the time of diagnosis were reviewed retrospectively. The demographic and clinical characteristics of the cases and serum TSH levels were recorded at the time of diagnosis and statistically analyzed. Results: A total of 329 cases with 322 papillary carcinomas and 7 follicular carcinomas were included in the study. The median age of the participants at the time of diagnosis was 45 (17-76) years. Eighty-three percent of the cases were diagnosed in stage 1, 6.7% in stage 2, 3.3% in stage 3, and 7.0% in stage 4. The median serum TSH level at the time of diagnosis of the cases was 1.34 (0.019.97) mIU/mL. We did not observe any statistically significant relationship between the serum TSH level and the stage of differentiated thyroid carcinoma, although higher serum TSH level was associated with lymph node metastasis and higher risk group in the American Thyroid Association (ATA) classification. Conclusion: The relationship between serum TSH level and thyroid cancer has not been clearly determined, but high TSH levels at the time of diagnosis were found to be associated with lymph node metastasis and medium-high ATA risk score.
{"title":"The Relationship Between TSH Level and Stage of Differentiated Thyroid Carcinoma","authors":"Esra Tunçez, M. Kulaksızoğlu, I. Tuncez","doi":"10.25179/tjem.2020-74747","DOIUrl":"https://doi.org/10.25179/tjem.2020-74747","url":null,"abstract":"Objective: The aim of this study was to determine whether thyroid-stimulating hormone (TSH) levels during the diagnosis of patients with differentiated thyroid carcinoma could be used for the prediction of cancer behavior. Material and Methods: The records of 329 patients with differentiated thyroid carcinoma who did not use levothyroxine at the time of diagnosis were reviewed retrospectively. The demographic and clinical characteristics of the cases and serum TSH levels were recorded at the time of diagnosis and statistically analyzed. Results: A total of 329 cases with 322 papillary carcinomas and 7 follicular carcinomas were included in the study. The median age of the participants at the time of diagnosis was 45 (17-76) years. Eighty-three percent of the cases were diagnosed in stage 1, 6.7% in stage 2, 3.3% in stage 3, and 7.0% in stage 4. The median serum TSH level at the time of diagnosis of the cases was 1.34 (0.019.97) mIU/mL. We did not observe any statistically significant relationship between the serum TSH level and the stage of differentiated thyroid carcinoma, although higher serum TSH level was associated with lymph node metastasis and higher risk group in the American Thyroid Association (ATA) classification. Conclusion: The relationship between serum TSH level and thyroid cancer has not been clearly determined, but high TSH levels at the time of diagnosis were found to be associated with lymph node metastasis and medium-high ATA risk score.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"11 1","pages":"230-236"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73312254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.25179/tjem.2019-66784
Yasar Nawaz, Sumbla Ghazanvi, Nadia Rasheed, S. Jahan, M. I. Ullah
Objective: The objective of the present study was to investigate the association of altered serum resistin levels to RETN gene (420C>G) polymorphism in women with polycystic ovarian syndrome (PCOS) and in healthy controls. Material and Methods: Eighty (40 PCOS cases and 40 healthy controls) individuals were included. Whole blood and serum samples were taken from all participants. Enzyme linked immunosorbent (ELISA) was performed for measuring the levels of serum resistin. Whole blood was used for extracting total genomic DNA by the phenol-chloroform method. Polymerase chain reaction with fragment length polymorphism was performed for detecting single nucleotide polymorphism (SNP) in the promoter region (-420 C>G) of the resistin (RETN) gene by amplifying the oligonucleotide sequence of the SNP. The amplified products were first confirmed on 2.0% agarose gel for product size, and then restriction digestion of these products was performed by using the Bpil restriction enzyme. After completion of digestion, the products were resolved on 2.5% agarose gel with a 100 bp DNA ladder, and the bands were inspected to infer genotype. Data analysis was done using SPSS software and the association between serum resistin levels and RETN genotypes was analyzed. Results: There was no significant difference (p=0.125) observed in serum resistin levels between PCOS cases (mean±SD=19.33±3.50) and healthy controls (mean±SD= 13.48±1.31). The frequency of the G allele was high in PCOS cases (65%) than in controls (53.7%). The GG genotype frequency of SNP (-420 C>G) was high in PCOS cases (40%) than in controls (20%), but no association was found (p=0.148). The high serum resistin levels were significantly associated with the GG genotype in PCOS cases (p=0.027). Conclusion: High serum resistin levels are not associated with the genotypes of RETN (-420 C>G) polymorphism in PCOS women and controls, although women with PCOS had high GG genotype levels of serum resistin. Further studies with large sample size should be conducted to explore the mechanism of genetic factors in complex diseases like PCOS.
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