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Metabolic Age: A New Predictor for Metabolic Syndrome 代谢年龄:代谢综合征的新预测因子
IF 0.2 Q4 Medicine Pub Date : 2021-01-01 DOI: 10.25179/TJEM.2020-79234
R. Mehrdad, Hamidreza Pouragha, Mohadeseh Vesal, G. Pouryaghoub, M. Naderzadeh, Z. Alemohammad
Center for Research on Occupational Diseases, Tehran University of Medical Sciences, IRAN *Occupational Health Department, School of Public Health, Tehran University of Medical Sciences, IRAN **Occupational Medicine Department, School of Medicine, Tehran University of Medical Sciences, IRAN ***Center for Research on Occupational Diseases, Tehran University of Medical Sciences, IRAN ****Center for Air Pollution Research, Institute for Environmental Research Tehran University of Medical Sciences, Tehran, IRAN *****Department of Occupational Medicine, School of Medicine, Occupational Sleep Research Center Baharlou Hospital, Tehran University of Medical Sciences, Tehran, IRAN Original Article Turk J Endocrinol Metab. 2021;25:78-86
伊朗德黑兰医科大学职业病研究中心*伊朗德黑兰医科大学公共卫生学院职业卫生系**伊朗德黑兰医科大学医学院职业医学系***伊朗德黑兰医科大学职业病研究中心****德黑兰医科大学环境研究所空气污染研究中心伊朗德黑兰*****伊朗德黑兰医科大学巴哈洛医院职业睡眠研究中心医学院职业医学系[J] .内分泌与医学杂志,2021;25:78-86
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引用次数: 0
Serum Irisin Levels in Cigarette Smokers 吸烟者血清中鸢尾素水平
IF 0.2 Q4 Medicine Pub Date : 2021-01-01 DOI: 10.25179/TJEM.2020-79650
B. Kırel, I. Alatas
Objective: Irisin, a newly discovered myokine, increases thermogenesis and energy consumption, especially after exercise. It has also been reported to stimulate the transformation of white fat cells into brown fat cells. Thus, it causes weight loss and increases the sensitivity to insulin. Nicotine affects the energy metabolism of the body through several mechanisms. Cigarette smokers are widely known to show decreased weight gain and increased weight loss. Since irisin and smoking/nicotine have similar effects on energy metabolism, this study proposed to determine the serum irisin levels in smokers. Material and Methods: Thirty-one healthy smokers aged 17-24 years and 31 agematched healthy non-smokers were included in this study. Serum irisin levels were determined using ELISA. Results: The smokers had been smoking for an average of 31±19 (2-84) months and smoked an average of 13.7±0.4 (5-25) cigarettes daily. The smokers had higher height and body weight and levels of serum creatinine and triglyceride and lower levels of HDL-C than non-smokers (p<0.05). Serum irisin levels and body mass index were not different between the two groups (p>0.05). The serum irisin level was correlated only with serum creatinine level in the entire group (r=-0.26, p<0.05). The serum irisin levels were not correlated with the duration and amount of cigarette smoking, as well as levels of serum glucose, insulin, total cholesterol, triglyceride, LDL-C, HDL-C, alanine aminotransferase, free T4, and TSH in the entire group (p>0.05). Conclusion: Serum irisin level in cigarette smokers is not different to that of non-smokers. It is not related to the duration and amount of cigarette smoking. Further prospective dose and time-controlled studies are needed to investigate whether similar effects of smoking/nicotine exposure on energy metabolism are related to irisin metabolism.
目的:鸢尾素是一种新发现的肌因子,能增加生热和能量消耗,尤其是在运动后。据报道,它还能刺激白色脂肪细胞向棕色脂肪细胞的转化。因此,它会导致体重减轻,并增加对胰岛素的敏感性。尼古丁通过几种机制影响身体的能量代谢。众所周知,吸烟的人体重增加减少,体重减轻。鉴于鸢尾素与吸烟/尼古丁对能量代谢的影响相似,本研究建议测定吸烟者血清中鸢尾素的水平。材料与方法:选取31名17-24岁的健康吸烟者和31名年龄匹配的健康非吸烟者为研究对象。ELISA法测定血清鸢尾素水平。结果:吸烟者平均吸烟31±19(2-84)个月,平均每天吸烟13.7±0.4(5-25)支。吸烟者的身高、体重、血清肌酐和甘油三酯水平均高于非吸烟者,HDL-C水平低于非吸烟者(p0.05)。全组血清鸢尾素水平仅与血清肌酐水平相关(r=-0.26, p0.05)。结论:吸烟者血清中鸢尾素水平与非吸烟者无明显差异。这与吸烟的持续时间和数量无关。需要进一步的前瞻性剂量和时间控制研究来调查吸烟/尼古丁暴露对能量代谢的类似影响是否与鸢尾素代谢有关。
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引用次数: 0
SRY-Positive 46-XX Testicular Disorder of Sex Development as a Rare Cause of Male Hypergonadotropic Hypogonadism: A Case Report sry阳性46-XX睾丸发育障碍是男性促性腺功能亢进症的罕见病因:1例报告
IF 0.2 Q4 Medicine Pub Date : 2021-01-01 DOI: 10.25179/TJEM.2020-73399
M. Can, M. Kocabaş, İ. Çordan, H. C. Burgucu, M. Karakose, M. Kulaksızoğlu, F. Karakurt
Introduction Disorders of sex development (DSD) are defined as situations where chromosome structure, gonads, or anatomical structure are incompatible with each other. One of these groups of disease, 46XX testicular DSD, was first reported in 1964 (1). The prevalence of 46XX testicular DSD is estimated to be 1 in 20,000 male births (2). Although pubic hair development and penis length post-puberty are normal, these patients have infertility associated with azoospermia (3). 46XX testicular DSD is diagnosed by evaluating clinical, endocrinological, and cytogenetic test results. The most important treatment method, testosterone replacement therapy, is necessary to improve sexual characteristics and sexual desire. In this report, we aimed to document a case of 46XX testicular DSD, who presented with complaints of small testes. 46XX testicular disorder of sex development (DSD) is a rare condition characterized by sexual differentiation disorder with testicular insufficiency. Normal sex development often complicates the diagnosis of this ailment in adults. Patients are usually diagnosed incidentally during infertility research. In this article, we aimed to highlight the hormonal, molecular, and cytogenetic results of an adult male patient diagnosed with 46XX testicular DSD suffering from hypergonadotropic hypogonadism.
性发育障碍(DSD)是指染色体结构、性腺或解剖结构不相容的情况。其中一组疾病46XX睾丸DSD于1964年首次报道(1)。46XX睾丸DSD的患病率估计为20,000名男性中有1名(2)。尽管青春期后阴毛发育和阴茎长度正常,但这些患者存在与无精子症相关的不育(3)。46XX睾丸DSD是通过评估临床、内分泌学和细胞遗传学检查结果来诊断的。最重要的治疗方法,睾酮替代疗法,是必要的,以改善性特征和性欲。在本报告中,我们的目的是记录一个46XX睾丸DSD的病例,他提出了小睾丸的抱怨。46XX睾丸性发育障碍(睾丸发育障碍)是一种罕见的以性别分化障碍伴睾丸功能不全为特征的疾病。在成人中,正常的性发育常常使这种疾病的诊断复杂化。患者通常在不孕症研究中被偶然诊断出来。在这篇文章中,我们旨在强调诊断为46XX睾丸DSD的成年男性患者患有高促性腺功能减退症的激素,分子和细胞遗传学结果。
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引用次数: 0
Does Blood Glucose Regulation in Adults with Type 2 Diabetes Affect Exocrine Pancreatic Functions? 成人2型糖尿病患者血糖调节是否影响胰腺外分泌功能?
IF 0.2 Q4 Medicine Pub Date : 2021-01-01 DOI: 10.25179/TJEM.2020-79839
S. Fidan, S. Kisioglu, C. K. Buruk, E. Ates, A. Coşar, H. O. Ersoz, O. Özgür
Department of Gastroenterology, Karadeniz Technical University Faculty of Medicine, Trabzon, TURKEY *Department of Endocrinology and Metabolism, Karadeniz Technical University Faculty of Medicine, Trabzon, TURKEY **Department of Medical Microbiology, Karadeniz Technical University Faculty of Medicine, Trabzon, TURKEY ***Department of Family Medicine, Karadeniz Technical University Faculty of Medicine, Trabzon, TURKEY Original Article Turk J Endocrinol Metab. 2021;25:87-94
土耳其特拉布松卡拉德尼兹技术大学医学院消化内科**土耳其特拉布松卡拉德尼兹技术大学医学院内分泌与代谢系**土耳其特拉布松卡拉德尼兹技术大学医学院医学微生物系***土耳其特拉布松卡拉德尼兹技术大学医学院家庭医学系[J]内分泌与医学杂志,2021;25:87-94
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引用次数: 0
Investigation of Survivin Promoter-31 G/C Polymorphism and Survivin Levels in Acromegaly 肢端肥大症患者Survivin启动子- 31g /C多态性及Survivin水平的研究
IF 0.2 Q4 Medicine Pub Date : 2021-01-01 DOI: 10.25179/TJEM.2020-77471
M. Ilhan, S. Turan, S. Turgut, Gurbet Korkmaz, N. Ozkan, Özcan İlhan Karamayaylim, E. Tasan
Department of Endocrinology and Metabolism, Bezmialem Vakif University Faculty of Medicine, İstanbul, TURKEY *Department of Molecular Medicine, The Institute of Experimental Medicine, İstanbul University, İstanbul, TURKEY **Department of Endocrinology and Metabolism, University of Health Science Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, TURKEY Original Article Turk J Endocrinol Metab. 2021;25:46-53
Bezmialem Vakif大学医学院内分泌与代谢学系İstanbul,土耳其* İstanbul大学实验医学研究所分子医学系İstanbul,土耳其**健康科学大学内分泌与代谢学系Bakırköy Sadi Konuk博士培训与研究医院İstanbul,土耳其[J] Endocrinol Metab. 2021;25:46-53
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引用次数: 0
Evaluation of Oxidative Stress with a New Method in Differentiated Thyroid Cancer Patients on Thyrotrophin Suppression Treatment 新方法评价分化型甲状腺癌患者在促甲状腺激素抑制治疗中的氧化应激
IF 0.2 Q4 Medicine Pub Date : 2021-01-01 DOI: 10.25179/TJEM.2020-78978
Abbas Ali Tam, D. Ozdemir, N. Bestepe, A. Alkan, Sevgul Fakı, O. Erel, R. Ersoy, B. Çakır
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引用次数: 0
Subacute Thyroiditis Secondary to SARS-COV-2 Infection; Case Studies From Turkey SARS-COV-2继发性亚急性甲状腺炎的研究土耳其案例研究
IF 0.2 Q4 Medicine Pub Date : 2021-01-01 DOI: 10.25179/tjem.2020-80585
Emine Kartal Baykan, A. Çarlıoğlu
Coronavirus disease-2019 (COVID-19) has infected more than 100 million people globally, with the pandemic still showing a quick increase in number. We reported five new cases in Turkey, where subacute thyroiditis was developed after the COVID-19 infection. Our study included three females and two male patients aged between 27 and 51 with a mean age of 39. Out of the five, four patients had a mild COVID-19 infection, and one patient had mild COVID-19 pneumonia. After 18-25 days of the disappearance of COVID-19 symptoms, subacute thyroiditis was developed in patients. Laboratory tests such as thyroid hormones and, especially, free thyroxin showed high levels while the thyroid-stimulating hormone was found to be low. The thyroid-stimulating hormone receptor antibody, anti-thyroid peroxidase, and anti-thyroglobulin antibodies were negative in all patients while the inflammatory markers were high. Thyroid ultrasound showed diffuse hypoechoic areas and diffused enlargement. There was no iodine uptake observed in the thyroid scintigraphy. The patients were diagnosed with subacute thyroiditis and prescribed oral prednisolone therapy. After a few days of starting the treatment, symptoms disappeared in all patients, and after four weeks of the onset of subacute thyroiditis symptoms, inflammatory markers turned to normal range in all patients. Therefore, physicians should consider subacute thyroiditis in the differential diagnosis of thyroid dysfunction during and after COVID-19 infection.
2019冠状病毒病(COVID-19)已在全球感染了1亿多人,而且感染人数仍在迅速增加。我们在土耳其报告了5例新病例,其中亚急性甲状腺炎是在COVID-19感染后发生的。我们的研究包括三名女性和两名男性患者,年龄在27至51岁之间,平均年龄39岁。5名患者中,4名患者为轻度感染,1名患者为轻度肺炎。在COVID-19症状消失18-25天后,患者出现亚急性甲状腺炎。甲状腺激素,尤其是游离甲状腺素等实验室检测结果显示水平较高,而促甲状腺激素则较低。所有患者促甲状腺激素受体抗体、抗甲状腺过氧化物酶抗体、抗甲状腺球蛋白抗体均为阴性,炎症标志物均较高。甲状腺超声示弥漫性低回声区及弥漫性增大。甲状腺显像未见碘摄取。患者被诊断为亚急性甲状腺炎并给予口服强的松龙治疗。开始治疗几天后,所有患者症状消失,亚急性甲状腺炎症状出现四周后,所有患者炎症指标恢复正常。因此,在COVID-19感染期间和之后的甲状腺功能障碍鉴别诊断中,医生应考虑亚急性甲状腺炎。
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引用次数: 1
Patients with Ectopic Posterior Pituitary: Report of 6 Patients 垂体后叶异位6例报告
IF 0.2 Q4 Medicine Pub Date : 2021-01-01 DOI: 10.25179/TJEM.2020-78916
Hatice Özişik, B. Yurekli, Ö. Kitiş, M. Erdogan, F. Saygili
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引用次数: 0
Evaluation of Influenza, Pneumococcus, Zoster, Measles, Diphtheria, and Pertussis Vaccination Rates in Patients with Type 1 and Type 2 Diabetes Mellitus; a Single-Center Experience From Turkey 1型和2型糖尿病患者流感、肺炎球菌、带状疱疹、麻疹、白喉和百日咳疫苗接种率的评价来自土耳其的单中心体验
IF 0.2 Q4 Medicine Pub Date : 2021-01-01 DOI: 10.25179/TJEM.2020-79458
A. Yeşilova, M. Bilge, N. Özsoy, M. Adaş
Objective: Several vaccines have been recommended for adults with diabetes. This study aimed to determine the rates of uptake of recommended vaccines in diabetic adults and estimate their association with sociodemographic and clinical factors. Material and Methods: This was a cross-sectional study conducted on patients with either type 1 or type 2 diabetes, who had attended the outpatient clinics of internal medicine and endocrinology. The patients were inquired about their immunization status against influenza, pneumococcus, zoster, measles, pertussis, and diphtheria. Results: Among the 350 diabetic patients, 38 (10.8%) had received a vaccine against pneumococcus, 90 (26%) against seasonal influenza, and only one patient had been administered the zoster vaccine. None of the patients had been vaccinated against measles, diphtheria, and pertussis. The rate of pneumococcal vaccination (PV) increased with age (65.5±9.7 vs. 57±9.1 [OR 2.9 (95% CI=14.32.67], p=0.005), although there was no such association between influenza vaccination (IV) and age (p=0.456). The rate of PV increased with the number of routine follow-up visits per year (10/38 vs. 28/38 [OR 4 (95% CI=0.994-16.096], (p=0.039). The rates of PV and IV were significantly higher in diabetic patients with chronic pulmonary disease (21/38 vs. 14/312 [OR 52.80 (95% CI 8.4333.1], p=0.005 and 31/90 vs. 4/260 [OR 29.15 (95% CI 3.37252.28], p=0.001) respectively. The rates of IV in diabetic patients with chronic renal failure were also significantly different from those without (27/90 vs. 8/260, [OR 14.28 95% CI 1.51-133.74], p=0.013). Conclusion: We observed low rates of vaccination against influenza, pneumococcus, and zoster in patients with diabetes, which were below the targets recommended by the World Health Organization.
目的:几种疫苗已被推荐用于成人糖尿病患者。本研究旨在确定糖尿病成人推荐疫苗的接种率,并估计其与社会人口统计学和临床因素的关系。材料和方法:这是一项横断面研究,研究对象为1型或2型糖尿病患者,这些患者曾在内科和内分泌科门诊就诊。调查患者的流感、肺炎球菌、带状疱疹、麻疹、百日咳和白喉免疫接种情况。结果:350例糖尿病患者中,38例(10.8%)接种了肺炎球菌疫苗,90例(26%)接种了季节性流感疫苗,仅有1例接种了带状疱疹疫苗。没有患者接种过麻疹、白喉和百日咳疫苗。肺炎球菌疫苗接种率(PV)随年龄的增加而增加(65.5±9.7比57±9.1 [OR = 2.9 (95% CI=14.32.67], p=0.005),但流感疫苗接种率(IV)与年龄没有相关性(p=0.456)。PV率随着每年常规随访次数的增加而增加(10/38 vs 28/38) [OR 4 (95% CI=0.994-16.096], (p=0.039)。糖尿病合并慢性肺部疾病患者PV和IV的发生率显著高于前者(21/38 vs. 14/312 [OR 52.80 (95% CI 8.4333.1), p=0.005)和后者(31/90 vs. 4/260 [OR 29.15 (95% CI 3.37252.28), p=0.001)。糖尿病合并慢性肾功能衰竭患者的静脉滴注率与未合并慢性肾功能衰竭患者也有显著差异(27/90 vs. 8/260, OR 14.28 95% CI 1.51-133.74, p=0.013)。结论:我们观察到糖尿病患者流感、肺炎球菌和带状疱疹疫苗接种率较低,低于世界卫生组织推荐的目标。
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引用次数: 2
Publication Outcomes for Oral Presentations at Congresses of Endocrinology and Metabolic Diseases of Turkey: Analysis of Twenty Years 土耳其内分泌学和代谢疾病大会口头报告的发表结果:二十年分析
IF 0.2 Q4 Medicine Pub Date : 2021-01-01 DOI: 10.25179/TJEM.2020-78932
Türkiye Endokrinoloji, Hastalıkları Kongresi, Sözlü Sunumlarının, Yayına Dönüşüm, Oranları Yirmi, Yılın Analizi, Emre S. Saygılı, E. Karakiliç, S. Sendur
Objective: This study aimed to analyze the publication rate for oral presentations at Congresses of Endocrinology and Metabolic Diseases of Turkey (CEMDT), their contribution to the literature, and variations over twenty years. Material and Methods: Presentations from 1997–2017 were accessed through congress booklets. PubMed and Google Scholar were used for the relevant literature search. Results: A total of 456 oral presentations were identified as having a publication conversion rate of 45.4% (207). These manuscripts were published in journals with a median impact factor (IF) of 2.79 (interquartile range (IQR): 1.77-3.58) and were found to receive a median of 9 (IQR: 3-21) citations. The publication rate in SCI/SCI-E indexed journals was 80.2% (166). The publication duration was a median of 20.6 months (IQR: 6-41 months). The multinational abstract rate was 6.8% (31), whereas 19.3% (88) of the abstracts comprised of retrospective data. The most frequent variation during the conversion to articles was a change in the order of the authors, which was observed in 65.71% (136) of cases. When the two ten-year periods from 1997-2006 and 2007-2017 are compared, the publication rate increased from 37.1% to 54.3% (p<0.01). Conclusion: This is the first study to evaluate the publication rate of the CEMDT presentations. The conversion rate for oral presentations to publication is high compared to studies from other branches of medical science in Turkey. However, it remains lower than the international congresses. There is a promising enhancement in the last ten years.
目的:本研究旨在分析土耳其内分泌与代谢疾病大会(CEMDT)口头报告的发表率、对文献的贡献以及20年来的变化。材料和方法:1997-2017年的报告可通过大会小册子查阅。使用PubMed和Google Scholar进行相关文献检索。结果:共有456篇口头报告被确定为发表转化率为45.4%(207篇)。这些论文发表在影响因子(IF)中位数为2.79(四分位间距(IQR)为1.77 ~ 3.58)的期刊上,被引用次数中位数为9 (IQR: 3 ~ 21)。在SCI/SCI- e索引期刊的发表率为80.2%(166篇)。发表时间中位数为20.6个月(IQR: 6-41个月)。跨国摘要率为6.8%(31篇),而由回顾性数据组成的摘要率为19.3%(88篇)。在转换成文章的过程中,最常见的变化是作者顺序的变化,占65.71%(136例)。比较1997-2006年和2007-2017年两个10年期,发表率从37.1%上升到54.3% (p<0.01)。结论:这是第一个评估CEMDT报告发表率的研究。与土耳其其他医学分支的研究相比,口头报告到出版物的转化率很高。然而,它仍然低于国际大会。在过去的十年里有了很大的发展。
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引用次数: 0
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Turkish Journal of Endocrinology and Metabolism
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