Pub Date : 2018-01-01DOI: 10.25179/TJEM.2018-61243
Guzin Cakmak, B. I. Aydoğan, C. Ersöz, E. Ozkan, S. Sak, S. Güllü
{"title":"Relation of 18F-FDG PET/CT Positivity with Tumor Cytopathology, Galectin-3, PTEN, Ki-67 and NIS Expressions in Thyroid Nodules","authors":"Guzin Cakmak, B. I. Aydoğan, C. Ersöz, E. Ozkan, S. Sak, S. Güllü","doi":"10.25179/TJEM.2018-61243","DOIUrl":"https://doi.org/10.25179/TJEM.2018-61243","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"277 1","pages":"176-182"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75424654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.25179/tjem.20182202-s32
G. Yalin, S. Doğanşen, A. Salmaslioglu, S. Tanrikulu, S. Yarman
{"title":"Evaluation of the Relationship Between Thyroid Nodules and Disease Activity in Patients with Acromegaly","authors":"G. Yalin, S. Doğanşen, A. Salmaslioglu, S. Tanrikulu, S. Yarman","doi":"10.25179/tjem.20182202-s32","DOIUrl":"https://doi.org/10.25179/tjem.20182202-s32","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"37 12 1","pages":"8-9"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78333306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.25179/TJEM.20182202-S09
H. Sav, U. Mousa
Introduction: Obesity is a public health problem involving both children and adults with an increasing prevalence in the World and North Cyprus. In this study we aimed to determine the prevalence of childhood obesity in our country and plan future studies. Subjects and Methods: In May-June 2007, we collected demographic, anthropometric and nutritional data of 7832 students between 12-15 years of age studying in 29 different secondary schools. We determined that the prevalence of obesity was 13.7% (1073); overweight 18.3% (1433); low body weight 3.5% (274). We invited 274 children in the obese group to our department of Endocrinology and Metabolism for anthropometric and metabolic analyses. Results: Two hundred and seventy four (53.6%) were girls and 127 (46.4%) were boys. The median age was 13.66. According to the National Cholesterol Education Program Adult Treatment Panel – III criteria (NCEP ATP III). 122 (44.5%) were diagnosed as Metabolic Syndrome (MetS). The body mass index percentiles correlated positively with the waist circumference, hip circumference and HOMA IR score (r= 0.53; p<0.001; r=0.54. p<0.001; r=0.15; p<0.05 respectively). HOMA IR correlated positively with systolic blood pressure. diastolic blood pressure. triglycerides. hip circumference. fasting blood glucose and waist circumference (r=0.19; p<0.001; r=0.17. p<0.001; r=0.28; p<0.001; r=0.23; p<0.001; r=0.25; p<0.001; r=0.30; p<0.001 respectively). According to Receiver operated characteristics (ROC) curves. a HOMA IR score of ≥2.15 predicted MetS with 90% sensitivity and 20% specificity. A HOMA IR score of ≥ 5.35 predicted MetS with 90% specificity and 29% sensitivity (AUC 0.619. %95 CI: 0.552-0.686. p<0.001). The mean TSH level of subjects with MetS was higher than those without Mets (3.84±3.09 vs. 2.94±1.91; p=0.004). The free T4 levels were similar in both groups. The prevalence of diabetes in the family was similar in subjects with and without MetS [73/122 (59.8%) vs. 105/152 (69.1%). p=0.127]. Conclusion: The prevalence of childhood obesity and associated comorbidities are similar in North Cyprus with other Mediterranean countries. S-09
{"title":"Prevalence of Childhood Obesity and Associated Morbidities in North Cyprus","authors":"H. Sav, U. Mousa","doi":"10.25179/TJEM.20182202-S09","DOIUrl":"https://doi.org/10.25179/TJEM.20182202-S09","url":null,"abstract":"Introduction: Obesity is a public health problem involving both children and adults with an increasing prevalence in the World and North Cyprus. In this study we aimed to determine the prevalence of childhood obesity in our country and plan future studies. Subjects and Methods: In May-June 2007, we collected demographic, anthropometric and nutritional data of 7832 students between 12-15 years of age studying in 29 different secondary schools. We determined that the prevalence of obesity was 13.7% (1073); overweight 18.3% (1433); low body weight 3.5% (274). We invited 274 children in the obese group to our department of Endocrinology and Metabolism for anthropometric and metabolic analyses. Results: Two hundred and seventy four (53.6%) were girls and 127 (46.4%) were boys. The median age was 13.66. According to the National Cholesterol Education Program Adult Treatment Panel – III criteria (NCEP ATP III). 122 (44.5%) were diagnosed as Metabolic Syndrome (MetS). The body mass index percentiles correlated positively with the waist circumference, hip circumference and HOMA IR score (r= 0.53; p<0.001; r=0.54. p<0.001; r=0.15; p<0.05 respectively). HOMA IR correlated positively with systolic blood pressure. diastolic blood pressure. triglycerides. hip circumference. fasting blood glucose and waist circumference (r=0.19; p<0.001; r=0.17. p<0.001; r=0.28; p<0.001; r=0.23; p<0.001; r=0.25; p<0.001; r=0.30; p<0.001 respectively). According to Receiver operated characteristics (ROC) curves. a HOMA IR score of ≥2.15 predicted MetS with 90% sensitivity and 20% specificity. A HOMA IR score of ≥ 5.35 predicted MetS with 90% specificity and 29% sensitivity (AUC 0.619. %95 CI: 0.552-0.686. p<0.001). The mean TSH level of subjects with MetS was higher than those without Mets (3.84±3.09 vs. 2.94±1.91; p=0.004). The free T4 levels were similar in both groups. The prevalence of diabetes in the family was similar in subjects with and without MetS [73/122 (59.8%) vs. 105/152 (69.1%). p=0.127]. Conclusion: The prevalence of childhood obesity and associated comorbidities are similar in North Cyprus with other Mediterranean countries. S-09","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"28 1","pages":"3-3"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82800628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.25179/tjem.2018-60184
M. Mogarekar, Mahendra G. Dhabe, Mayuri Madhukarrao Palmate
D O I: 10 .2 51 79 /t je m .2 01 860 18 4 Objective: This study aims to investigate the role of paraoxonase 1 activity and Q192R polymorphism in the development of nephropathy in patients with Type 2 diabetes mellitus. Material and Methods: This case-control study included 100 patients with Type 2 diabetes mellitus for more than five years, admitted to our hospital. They were divided into two groups (with and without diabetic nephropathy) on the basis of albumin-creatinine ratio. Serum samples of all patients were subjected to paraoxonase 1 arylesterase activity, using phenylacetate as the substrate. Paraoxonase 1 phenotyping was carried out by calculating the ratio of inhibited arylesterase activity to non-inhibited arylesterase activity using phenylacetate and p-nitrophenyl acetate, respectively, as substrates. Results: Paraoxonase 1 arylesterase activity was found to be significantly lower in subjects with diabetic nephropathy than that in the subjects without diabetic nephropathy (85.4±24.12 vs. 127.94±25.51 p=0.01). Bothunivariate (Odds ratio=1.073, Neglekerke’s R2=0.565, area under the curve=0.888, p≤0.001) and multivariate (Odds ratio= 1.067, [95% confidence interval (1.023-1.113), p=0.003)] logistic tests showed independent, protective association of paraoxonase 1 arylesterase activity with the development of diabetic nephropathy. Paraoxonase 1 RR homozygous diabetic patients were observed to be significantly associated with diabetic nephropathy in the univariate logistic regression (R2=0.056 area under the curve=0.600 p=0.037), while the multivariate analysis did not show any significance. Conclusion: A decreased paraoxonase 1 arylesterase activity may be considered to be an additional risk factor in the development of nephropathy in diabetes mellitus. Paraoxonase 1 RR homozygous individuals may be at an increased risk of being affected by diabetic nephropathy.
{"title":"Paraoxonase 1 Activity and its Polymorphism in Type 2 Diabetic Nephropathy","authors":"M. Mogarekar, Mahendra G. Dhabe, Mayuri Madhukarrao Palmate","doi":"10.25179/tjem.2018-60184","DOIUrl":"https://doi.org/10.25179/tjem.2018-60184","url":null,"abstract":"D O I: 10 .2 51 79 /t je m .2 01 860 18 4 Objective: This study aims to investigate the role of paraoxonase 1 activity and Q192R polymorphism in the development of nephropathy in patients with Type 2 diabetes mellitus. Material and Methods: This case-control study included 100 patients with Type 2 diabetes mellitus for more than five years, admitted to our hospital. They were divided into two groups (with and without diabetic nephropathy) on the basis of albumin-creatinine ratio. Serum samples of all patients were subjected to paraoxonase 1 arylesterase activity, using phenylacetate as the substrate. Paraoxonase 1 phenotyping was carried out by calculating the ratio of inhibited arylesterase activity to non-inhibited arylesterase activity using phenylacetate and p-nitrophenyl acetate, respectively, as substrates. Results: Paraoxonase 1 arylesterase activity was found to be significantly lower in subjects with diabetic nephropathy than that in the subjects without diabetic nephropathy (85.4±24.12 vs. 127.94±25.51 p=0.01). Bothunivariate (Odds ratio=1.073, Neglekerke’s R2=0.565, area under the curve=0.888, p≤0.001) and multivariate (Odds ratio= 1.067, [95% confidence interval (1.023-1.113), p=0.003)] logistic tests showed independent, protective association of paraoxonase 1 arylesterase activity with the development of diabetic nephropathy. Paraoxonase 1 RR homozygous diabetic patients were observed to be significantly associated with diabetic nephropathy in the univariate logistic regression (R2=0.056 area under the curve=0.600 p=0.037), while the multivariate analysis did not show any significance. Conclusion: A decreased paraoxonase 1 arylesterase activity may be considered to be an additional risk factor in the development of nephropathy in diabetes mellitus. Paraoxonase 1 RR homozygous individuals may be at an increased risk of being affected by diabetic nephropathy.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"46 1","pages":"151-157"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86699109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.25179/TJEM.20182202-P113
G. Cansu, B. Taskiran
{"title":"Retrospective Analysis of Patients with Hypoparathyroidism","authors":"G. Cansu, B. Taskiran","doi":"10.25179/TJEM.20182202-P113","DOIUrl":"https://doi.org/10.25179/TJEM.20182202-P113","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"48 1","pages":"47-47"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88535387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.25179/TJEM.2018-59661
Masoume Akhbari, A. Biglari, M. Farahani, M. Khalili, F. Bandarian
{"title":"Expression Level of Circulating miR-93 in Serum of Patients with Diabetic Nephropathy","authors":"Masoume Akhbari, A. Biglari, M. Farahani, M. Khalili, F. Bandarian","doi":"10.25179/TJEM.2018-59661","DOIUrl":"https://doi.org/10.25179/TJEM.2018-59661","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"29 1","pages":"78-84"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81218737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.25179/TJEM.2018-59842
A. Bişgin
{"title":"LEPR Deficiency: Prevalence and Importance of a Novel Mutation and Significant Genetic Variants, Usually Underestimated","authors":"A. Bişgin","doi":"10.25179/TJEM.2018-59842","DOIUrl":"https://doi.org/10.25179/TJEM.2018-59842","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"17 1","pages":"85-90"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87139729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.25179/tjem.20182202-p129
E. Cagiltay, F. Akay
Objective: Clinical manifestations of GO are caused by the over compression of orbital tissues within the restricted orbital bone cavity. Impaired ocular blood flow may disrupt the retinal microstructure and functions.. In this study we aimed to investigate the macular and choroidal thickness changes in GO compared with healthy subjects. Materials and Methods: The study group comprised 50 adult patients with previously diagnosed Graves’ Disease with ophthalmopathy who were on anti-thyroid treatment. For the assessment of GO activity. VISA (vision. inflammation. strabismus. and appearance) inflammatory score was used. When euthryoidism was achieved without side effects. the patients were referred to the ophthalmology clinic for Spectraldomain optical coherence tomography (SD-OCT) evaluation. Results: Subfoveal. mean and temporal choroidal thicknesses were increased significantly in study group according to the controls. The mean choroidal thickness was elevated. Conclusions: This elevation is because of the retroorbital inflammation even in this non-severe GO group. Choroidal thickness might be affected from the venous obstruction and congestion in patients with GO. The elevation of the choroidal thickness might be an early sign of venous congestion that occurs before the elevation of intraocular pressure.
{"title":"Evaluation of Choroidal Thickness Changes in Euthyroid Graves’ Ophthalmopathy","authors":"E. Cagiltay, F. Akay","doi":"10.25179/tjem.20182202-p129","DOIUrl":"https://doi.org/10.25179/tjem.20182202-p129","url":null,"abstract":"Objective: Clinical manifestations of GO are caused by the over compression of orbital tissues within the restricted orbital bone cavity. Impaired ocular blood flow may disrupt the retinal microstructure and functions.. In this study we aimed to investigate the macular and choroidal thickness changes in GO compared with healthy subjects. Materials and Methods: The study group comprised 50 adult patients with previously diagnosed Graves’ Disease with ophthalmopathy who were on anti-thyroid treatment. For the assessment of GO activity. VISA (vision. inflammation. strabismus. and appearance) inflammatory score was used. When euthryoidism was achieved without side effects. the patients were referred to the ophthalmology clinic for Spectraldomain optical coherence tomography (SD-OCT) evaluation. Results: Subfoveal. mean and temporal choroidal thicknesses were increased significantly in study group according to the controls. The mean choroidal thickness was elevated. Conclusions: This elevation is because of the retroorbital inflammation even in this non-severe GO group. Choroidal thickness might be affected from the venous obstruction and congestion in patients with GO. The elevation of the choroidal thickness might be an early sign of venous congestion that occurs before the elevation of intraocular pressure.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"17 1","pages":"53-54"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73081268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.25179/tjem.2018-59939
K. U. Bhaskhar, H. Devi, A. Bitla, S. Rao, S. Kumar, A. Sachan
{"title":"Ischemia Modified Albumin Levels in Patients with Diabetic Nephropathy","authors":"K. U. Bhaskhar, H. Devi, A. Bitla, S. Rao, S. Kumar, A. Sachan","doi":"10.25179/tjem.2018-59939","DOIUrl":"https://doi.org/10.25179/tjem.2018-59939","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"10 1","pages":"145-150"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82591692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.25179/tjem.20182202-p054
E. Güneş, Şirin Zelal Şahin Tirnova, E. Erturk
{"title":"Rapid Visual Improvement After Cabergoline Therapy in a Macroprolactinoma Case","authors":"E. Güneş, Şirin Zelal Şahin Tirnova, E. Erturk","doi":"10.25179/tjem.20182202-p054","DOIUrl":"https://doi.org/10.25179/tjem.20182202-p054","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"21 1","pages":"29-30"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82606330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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