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Relation of 18F-FDG PET/CT Positivity with Tumor Cytopathology, Galectin-3, PTEN, Ki-67 and NIS Expressions in Thyroid Nodules 甲状腺结节18F-FDG PET/CT阳性与肿瘤细胞病理学、半乳糖凝集素-3、PTEN、Ki-67、NIS表达的关系
IF 0.2 Q4 Medicine Pub Date : 2018-01-01 DOI: 10.25179/TJEM.2018-61243
Guzin Cakmak, B. I. Aydoğan, C. Ersöz, E. Ozkan, S. Sak, S. Güllü
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引用次数: 0
Evaluation of the Relationship Between Thyroid Nodules and Disease Activity in Patients with Acromegaly 肢端肥大症患者甲状腺结节与疾病活动度关系的评价
IF 0.2 Q4 Medicine Pub Date : 2018-01-01 DOI: 10.25179/tjem.20182202-s32
G. Yalin, S. Doğanşen, A. Salmaslioglu, S. Tanrikulu, S. Yarman
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引用次数: 0
Prevalence of Childhood Obesity and Associated Morbidities in North Cyprus 北塞浦路斯儿童肥胖患病率及相关发病率
IF 0.2 Q4 Medicine Pub Date : 2018-01-01 DOI: 10.25179/TJEM.20182202-S09
H. Sav, U. Mousa
Introduction: Obesity is a public health problem involving both children and adults with an increasing prevalence in the World and North Cyprus. In this study we aimed to determine the prevalence of childhood obesity in our country and plan future studies. Subjects and Methods: In May-June 2007, we collected demographic, anthropometric and nutritional data of 7832 students between 12-15 years of age studying in 29 different secondary schools. We determined that the prevalence of obesity was 13.7% (1073); overweight 18.3% (1433); low body weight 3.5% (274). We invited 274 children in the obese group to our department of Endocrinology and Metabolism for anthropometric and metabolic analyses. Results: Two hundred and seventy four (53.6%) were girls and 127 (46.4%) were boys. The median age was 13.66. According to the National Cholesterol Education Program Adult Treatment Panel – III criteria (NCEP ATP III). 122 (44.5%) were diagnosed as Metabolic Syndrome (MetS). The body mass index percentiles correlated positively with the waist circumference, hip circumference and HOMA IR score (r= 0.53; p<0.001; r=0.54. p<0.001; r=0.15; p<0.05 respectively). HOMA IR correlated positively with systolic blood pressure. diastolic blood pressure. triglycerides. hip circumference. fasting blood glucose and waist circumference (r=0.19; p<0.001; r=0.17. p<0.001; r=0.28; p<0.001; r=0.23; p<0.001; r=0.25; p<0.001; r=0.30; p<0.001 respectively). According to Receiver operated characteristics (ROC) curves. a HOMA IR score of ≥2.15 predicted MetS with 90% sensitivity and 20% specificity. A HOMA IR score of ≥ 5.35 predicted MetS with 90% specificity and 29% sensitivity (AUC 0.619. %95 CI: 0.552-0.686. p<0.001). The mean TSH level of subjects with MetS was higher than those without Mets (3.84±3.09 vs. 2.94±1.91; p=0.004). The free T4 levels were similar in both groups. The prevalence of diabetes in the family was similar in subjects with and without MetS [73/122 (59.8%) vs. 105/152 (69.1%). p=0.127]. Conclusion: The prevalence of childhood obesity and associated comorbidities are similar in North Cyprus with other Mediterranean countries. S-09
肥胖症是一个涉及儿童和成人的公共卫生问题,在世界和北塞浦路斯的发病率越来越高。在这项研究中,我们旨在确定我国儿童肥胖的患病率,并计划未来的研究。对象与方法:2007年5 - 6月,我们收集了29所不同中学12-15岁的7832名学生的人口统计学、人体测量学和营养数据。我们确定肥胖患病率为13.7% (1073);超重18.3% (1433);体重低3.5%(274)。我们邀请了274名肥胖组的儿童到内分泌和代谢科进行人体测量和代谢分析。结果:女生274例(53.6%),男生127例(46.4%)。中位年龄为13.66岁。根据国家胆固醇教育计划成人治疗小组- III标准(NCEP ATP III), 122(44.5%)被诊断为代谢综合征(MetS)。体重指数百分位数与腰围、臀围、HOMA IR评分呈正相关(r= 0.53;p < 0.001;r = 0.54。p < 0.001;r = 0.15;p < 0.05)。HOMA - IR与收缩压呈正相关。舒张压。甘油三酯。臀围。空腹血糖与腰围(r=0.19;p < 0.001;r = 0.17。p < 0.001;r = 0.28;p < 0.001;r = 0.23;p < 0.001;r = 0.25;p < 0.001;r = 0.30;p < 0.001)。根据受试者工作特征(ROC)曲线。HOMA IR评分≥2.15,预测MetS的敏感性为90%,特异性为20%。HOMA IR评分≥5.35预测met的特异性为90%,敏感性为29% (AUC为0.619)。%95 ci: 0.552-0.686。p < 0.001)。有MetS的受试者TSH平均水平高于无MetS的受试者(3.84±3.09 vs. 2.94±1.91;p = 0.004)。两组的游离T4水平相似。有和没有MetS的家庭中糖尿病患病率相似[73/122 (59.8%)vs. 105/152(69.1%)]。p = 0.127)。结论:北塞浦路斯儿童肥胖及相关合并症的患病率与其他地中海国家相似。S-09
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引用次数: 0
Paraoxonase 1 Activity and its Polymorphism in Type 2 Diabetic Nephropathy 对氧磷酶1在2型糖尿病肾病中的活性及其多态性
IF 0.2 Q4 Medicine Pub Date : 2018-01-01 DOI: 10.25179/tjem.2018-60184
M. Mogarekar, Mahendra G. Dhabe, Mayuri Madhukarrao Palmate
D O I: 10 .2 51 79 /t je m .2 01 860 18 4 Objective: This study aims to investigate the role of paraoxonase 1 activity and Q192R polymorphism in the development of nephropathy in patients with Type 2 diabetes mellitus. Material and Methods: This case-control study included 100 patients with Type 2 diabetes mellitus for more than five years, admitted to our hospital. They were divided into two groups (with and without diabetic nephropathy) on the basis of albumin-creatinine ratio. Serum samples of all patients were subjected to paraoxonase 1 arylesterase activity, using phenylacetate as the substrate. Paraoxonase 1 phenotyping was carried out by calculating the ratio of inhibited arylesterase activity to non-inhibited arylesterase activity using phenylacetate and p-nitrophenyl acetate, respectively, as substrates. Results: Paraoxonase 1 arylesterase activity was found to be significantly lower in subjects with diabetic nephropathy than that in the subjects without diabetic nephropathy (85.4±24.12 vs. 127.94±25.51 p=0.01). Bothunivariate (Odds ratio=1.073, Neglekerke’s R2=0.565, area under the curve=0.888, p≤0.001) and multivariate (Odds ratio= 1.067, [95% confidence interval (1.023-1.113), p=0.003)] logistic tests showed independent, protective association of paraoxonase 1 arylesterase activity with the development of diabetic nephropathy. Paraoxonase 1 RR homozygous diabetic patients were observed to be significantly associated with diabetic nephropathy in the univariate logistic regression (R2=0.056 area under the curve=0.600 p=0.037), while the multivariate analysis did not show any significance. Conclusion: A decreased paraoxonase 1 arylesterase activity may be considered to be an additional risk factor in the development of nephropathy in diabetes mellitus. Paraoxonase 1 RR homozygous individuals may be at an increased risk of being affected by diabetic nephropathy.
目的:探讨对氧磷酶1活性及Q192R多态性在2型糖尿病肾病发生中的作用。材料与方法:本病例对照研究纳入我院收治的5年以上2型糖尿病患者100例。根据白蛋白-肌酐比值将患者分为两组(伴有和不伴有糖尿病肾病)。以苯乙酸为底物,对所有患者的血清样本进行对氧磷酶1芳基酯酶活性测定。分别以乙酸苯酯和对硝基苯乙酸酯为底物,通过计算抑制芳基酯酶活性与未抑制芳基酯酶活性的比值来进行对氧磷酶1表型分型。结果:糖尿病肾病组对氧磷酶1芳基酯酶活性明显低于非糖尿病肾病组(85.4±24.12∶127.94±25.51 p=0.01)。单因素logistic检验(优势比=1.073,Neglekerke’s R2=0.565,曲线下面积=0.888,p≤0.001)和多因素logistic检验(优势比= 1.067,95%可信区间(1.023-1.113),p=0.003)均显示对氧磷酶1芳基酯酶活性与糖尿病肾病的发生具有独立的保护作用。单因素logistic回归(R2=0.056,曲线下面积=0.600,p=0.037)观察到对氧onase 1 RR纯合型糖尿病患者与糖尿病肾病有显著相关性,多因素分析无显著性。结论:对氧磷酶1芳基酯酶活性降低可能被认为是糖尿病肾病发展的另一个危险因素。对氧磷酶1 RR纯合子个体患糖尿病肾病的风险可能增加。
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引用次数: 1
Retrospective Analysis of Patients with Hypoparathyroidism 甲状旁腺功能减退症患者回顾性分析
IF 0.2 Q4 Medicine Pub Date : 2018-01-01 DOI: 10.25179/TJEM.20182202-P113
G. Cansu, B. Taskiran
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引用次数: 0
Expression Level of Circulating miR-93 in Serum of Patients with Diabetic Nephropathy 糖尿病肾病患者血清循环miR-93的表达水平
IF 0.2 Q4 Medicine Pub Date : 2018-01-01 DOI: 10.25179/TJEM.2018-59661
Masoume Akhbari, A. Biglari, M. Farahani, M. Khalili, F. Bandarian
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引用次数: 5
LEPR Deficiency: Prevalence and Importance of a Novel Mutation and Significant Genetic Variants, Usually Underestimated LEPR缺陷:一种新突变和显著遗传变异的流行和重要性,通常被低估
IF 0.2 Q4 Medicine Pub Date : 2018-01-01 DOI: 10.25179/TJEM.2018-59842
A. Bişgin
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引用次数: 0
Evaluation of Choroidal Thickness Changes in Euthyroid Graves’ Ophthalmopathy 甲状腺功能正常的Graves眼病脉络膜厚度变化的评价
IF 0.2 Q4 Medicine Pub Date : 2018-01-01 DOI: 10.25179/tjem.20182202-p129
E. Cagiltay, F. Akay
Objective: Clinical manifestations of GO are caused by the over compression of orbital tissues within the restricted orbital bone cavity. Impaired ocular blood flow may disrupt the retinal microstructure and functions.. In this study we aimed to investigate the macular and choroidal thickness changes in GO compared with healthy subjects. Materials and Methods: The study group comprised 50 adult patients with previously diagnosed Graves’ Disease with ophthalmopathy who were on anti-thyroid treatment. For the assessment of GO activity. VISA (vision. inflammation. strabismus. and appearance) inflammatory score was used. When euthryoidism was achieved without side effects. the patients were referred to the ophthalmology clinic for Spectraldomain optical coherence tomography (SD-OCT) evaluation. Results: Subfoveal. mean and temporal choroidal thicknesses were increased significantly in study group according to the controls. The mean choroidal thickness was elevated. Conclusions: This elevation is because of the retroorbital inflammation even in this non-severe GO group. Choroidal thickness might be affected from the venous obstruction and congestion in patients with GO. The elevation of the choroidal thickness might be an early sign of venous congestion that occurs before the elevation of intraocular pressure.
目的:氧化石墨烯的临床表现是由于受限眶骨腔内眶组织过度受压所致。眼血流受损可能会破坏视网膜的微观结构和功能。在本研究中,我们旨在研究氧化石墨烯与健康受试者相比黄斑和脉络膜厚度的变化。材料和方法:研究组包括50例既往诊断为Graves病合并眼病并接受抗甲状腺治疗的成年患者。用于评价氧化石墨烯活性。签证(愿景。炎症。斜视。采用外观炎症评分法。当甲状腺功能恢复正常且无副作用时。转至眼科门诊进行光谱域光学相干断层扫描(SD-OCT)评估。结果:Subfoveal。与对照组相比,研究组的平均脉络膜厚度和颞部脉络膜厚度均显著增加。脉络膜平均厚度增高。结论:即使在非严重氧化石墨烯组中,这种升高也是由于眶后炎症。GO患者静脉阻塞和充血可能影响脉络膜厚度。脉络膜厚度的升高可能是发生在眼压升高之前的静脉充血的早期征兆。
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引用次数: 0
Ischemia Modified Albumin Levels in Patients with Diabetic Nephropathy 糖尿病肾病患者缺血改变的白蛋白水平
IF 0.2 Q4 Medicine Pub Date : 2018-01-01 DOI: 10.25179/tjem.2018-59939
K. U. Bhaskhar, H. Devi, A. Bitla, S. Rao, S. Kumar, A. Sachan
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引用次数: 0
Rapid Visual Improvement After Cabergoline Therapy in a Macroprolactinoma Case 卡麦角林治疗1例巨催乳素瘤后视力迅速改善
IF 0.2 Q4 Medicine Pub Date : 2018-01-01 DOI: 10.25179/tjem.20182202-p054
E. Güneş, Şirin Zelal Şahin Tirnova, E. Erturk
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引用次数: 0
期刊
Turkish Journal of Endocrinology and Metabolism
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