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The Use of Thyroid Hormones in Hypothyroid and Euthyroid Patients: A THESIS* Questionnaire Survey of Turkish Physicians 甲状腺功能减退和甲状腺功能正常患者甲状腺激素的使用:一篇论文*土耳其医生的问卷调查
IF 0.2 Q4 Medicine Pub Date : 2022-07-01 DOI: 10.5152/tjem.2022.22024
G. Ayvaz, E. Akarsu, R. Attanasio, L. Hegedűs, E. Nagy, E. Papini, P. Perros
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引用次数: 3
Effectiveness of Cabergoline in Reduction of Tumor Volume and Suppression of Prolactin in Treatment-Naive Prolactinomas and the Correlation of T2-weighted Signal Characteristics of Adenomas with Their Response to Treatment 卡麦角林在治疗初发催乳素瘤中减小肿瘤体积和抑制催乳素的有效性及腺瘤t2加权信号特征与治疗反应的相关性
IF 0.2 Q4 Medicine Pub Date : 2022-07-01 DOI: 10.5152/tjem.2022.22039
Musadiq Adil Sheikh, A. Parry, Feroze A. Shaheen, M. Ganie, N. Choh, A. Bhat
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引用次数: 1
Evaluation of Anxiety and Perceived Stress Levels in Patients with Acromegaly After the First Lockdown of the Coronavirus Disease 2019 Pandemic 2019冠状病毒病大流行第一次封锁后肢端肥大症患者焦虑和感知压力水平的评估
IF 0.2 Q4 Medicine Pub Date : 2022-07-01 DOI: 10.5152/tjem.2022.21995
S. Turgut, H. Pişkinpaşa, Didem Acarer Bugun, O. Karaarslan, E. Bozkur, N. Pamuk, İ. Cakir, M. Mert, S. Çiftçi Doğanşen
Objective: The aim of this study is to examine and compare the anxiety level and stress perception of acromegaly patients with controlled and active disease in the coronavirus disease 2019 pandemic. Methods: A total of 49 (23 females/26 males) patients applied to the outpatient clinic during the month after the first lockdown of the pandemic period were recruited in this cross-sectional study. State-Trait Anxiety Inventory (S-Anxiety for state scale, T-Anxiety for trait scale) and Perceived Stress Scale-14 were used to evaluate the event-related current state anxiety, the general tendency to anxiety, and perceived stressful situations. Patients were divided into 2 groups as active (n = 14) and well controlled (n = 35) patient groups and compared. Results: The active acromegaly group had significantly higher scores than well-controlled patients on all the S-Anxiety (P = .011), T-Anxiety (P = .002), and Perceived Stress Scale-14 (P = .007) scores after controlling for age, gender, body mass index, education years, marital and occupation status, disease duration, and disease-specific medical treatment status covariates. S-Anxiety (P = .021), T-Anxiety (P = .004), and Perceived Stress Scale-14 (P = .009) scores were found significantly higher in single patients than in married ones. Conclusion: This study showed significantly increased anxiety and perceived stress levels after the first lockdown of the coronavirus disease 2019 pandemic, especially in the active and single acromegaly patients compared to the well-controlled and married ones. Psychiatric symptoms should be carefully evaluated in the follow-up of acromegaly patients. The necessary psychological support should be provided to patients by focusing on these symptoms to improve patient management, particularly in a health-related stressful situation such as the coronavirus disease 2019 pandemic.
目的:探讨2019冠状病毒病大流行中控制型和活动性肢端肥大症患者的焦虑水平和应激感知。方法:在本横断面研究中,共招募了49例(23名女性/26名男性)在大流行期间第一次封锁后的一个月内申请门诊的患者。使用状态-特质焦虑量表(s -焦虑状态量表、t-焦虑特质量表)和感知压力量表-14评估事件相关的当前状态焦虑、总体焦虑倾向和感知压力情境。将患者分为活跃组(n = 14)和对照组(n = 35)两组进行比较。结果:在控制了年龄、性别、体重指数、受教育年限、婚姻和职业状况、病程、疾病特异性医疗状况等变量后,活动期肢端肥大症组的S-Anxiety (P = 0.011)、T-Anxiety (P = 0.002)、Perceived Stress -14 (P = 0.007)得分均显著高于对照组。单身患者S-Anxiety (P = 0.021)、T-Anxiety (P = 0.004)、Perceived Stress Scale-14 (P = 0.009)得分均显著高于已婚患者。结论:本研究显示,与控制良好的已婚肢端肥大患者相比,2019冠状病毒病大流行首次封锁后,活跃和单身肢端肥大患者的焦虑和感知压力水平显著增加。肢端肥大症患者随访时应仔细评估精神症状。应重点关注这些症状,为患者提供必要的心理支持,以改善患者管理,特别是在2019年冠状病毒病大流行等与健康相关的压力情况下。
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引用次数: 1
Postpartum Lactation Failure Secondary to Isolated Prolactin Deficiency: A Case Report and Literature Review 孤立性催乳素缺乏继发于产后泌乳失败1例报告及文献复习
IF 0.2 Q4 Medicine Pub Date : 2022-07-01 DOI: 10.5152/tjem.2022.22048
A. Bilen, H. Bilen, Esra Gungor Albayrak, Y. Karadeniz, N. Gokkaya
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引用次数: 0
Late-Onset Non-islet Cell Tumor Hypoglycemia Associated with a Pleural Solitary Fibrous Tumor 迟发性非胰岛细胞肿瘤低血糖与胸膜孤立性纤维性肿瘤相关
IF 0.2 Q4 Medicine Pub Date : 2022-07-01 DOI: 10.5152/tjem.2022.22021
Aasim N. Maldar, Phulrenu H. Chauhan, M. Lala, R. Deshpande
A 53-year-old, non-diabetic lady was evaluated for worsening breathlessness over the past 1 year. She was diagnosed with a lung lesion a year ago, but the prevailing COVID-19 situation prevented her from seeking further evaluation. She began to have early morning episodes of symptomatic hypoglycemia over the previous 4 months, which were relieved with dextrose infusions. The evaluation showed low insulin, low C-peptide, and high insulin-like growth factor-2 to insulin-like growth factor-1 ratio. High-resolution computed tomography scan of the thorax showed a 19.5 cm x 16.6 cm x 23.8 cm mass in the left hemithorax, and a microscopic examination of a biopsy specimen of which was consistent with the diagnosis of solitary fibrous tumor. The patient underwent sternotomy with left anterior thoracotomy with successful excision of the fibrous tumor. Post-operatively, histopathological diagnosis of solitary fibrous tumor was confirmed. There were no further episodes of hypoglycemia, and the patient was completely recovered.
一位53岁的非糖尿病女性在过去一年中因呼吸困难恶化而被评估。一年前,她被诊断出肺部病变,但目前的COVID-19形势使她无法寻求进一步的评估。在过去的4个月里,她开始有清晨发作的症状性低血糖,经葡萄糖输注缓解。评价结果显示低胰岛素,低c肽,高胰岛素样生长因子-2与胰岛素样生长因子-1比值。胸部高分辨率计算机断层扫描显示左半胸有一个19.5 cm x 16.6 cm x 23.8 cm的肿块,活检标本的显微镜检查与孤立性纤维性肿瘤的诊断一致。病人接受了胸骨切开术和左前胸切开术,成功切除了纤维性肿瘤。术后病理确诊为孤立性纤维性肿瘤。再无低血糖发作,患者完全康复。
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引用次数: 0
Dual Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 Receptor Agonists 双葡萄糖依赖性胰岛素多肽和胰高血糖素样肽-1受体激动剂
IF 0.2 Q4 Medicine Pub Date : 2022-07-01 DOI: 10.5152/tjem.2022.22003
D. Tuzun
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引用次数: 0
A Giant Urinary Bladder Paraganglioma 巨大膀胱副神经节瘤
IF 0.2 Q4 Medicine Pub Date : 2022-07-01 DOI: 10.5152/tjem.2022.22054
R. Misgar, M. S. Baba, A. Bhat, A. Khawaja, M. I. Lone, M. Bashir, A. Wani
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引用次数: 0
The Association Between Somatostatin Receptor Ligand and Vitamin B12 in Patients with Acromegaly 肢端肥大症患者生长抑素受体配体与维生素B12的关系
IF 0.2 Q4 Medicine Pub Date : 2022-07-01 DOI: 10.5152/tjem.2022.22030
S. Şahin, T. Eşkazan, E. Çiçek, Y. Yagiz Ozogul, E. Durcan, C. Sulu, Hande Mefkure Ozkaya, A. I. Hatemi, P. Kadıoğlu
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引用次数: 0
A Case Report of Dapagliflozin-Induced Nodular Vasculitis 达格列净致结节性血管炎1例
IF 0.2 Q4 Medicine Pub Date : 2021-01-01 DOI: 10.25179/TJEM.2020-80188
M. Kocabaş, Z. Yarar, İ. Çordan, M. Can, H. C. Burgucu, H. Aydemir, M. Karakose, M. Kulaksızoğlu, F. Karakurt
Introduction Nodular vasculitis (NV) was first mentioned by Montgomery in 1945 for erythema induratum-like lesions (1). NV is a rare form of panniculitis and is usually localized on the calves. Characterized by plaques and erythematous nodules, NV may occasionally show ulceration and draining. It is considered a reactive disease associated with many causative factors (2). Some of the infectious causereported in previous studies for NV are Tuberculosis, Nocardia, Fusarium, Pseudomonas, Chlamydia, and hepatitis C virus (3-5). Some cases of NV have also been found associated with non-infectious conditions such as drugs (6,7), inflammatory bowel diseases (8), several autoimmune diseases (9), and rare malignant diseases (10,11). Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are oral antidiabetic drugs that inNodular vasculitis (NV), first described by Montgomery in 1945 for erythema induratum-like lesions, is a rare form of panniculitis that is particularly localized on the calves. Characterized by plaques and erythematous nodules, NV may often show ulceration and draining. It is known as a reactive disease associated with many causative factors. Several NV cases due to infectious or non-infectious causative factors have been reported, but no case of NV due to sodium-glucose cotransporter-2 inhibitors (SGLT2i) has yet been reported. In this case report, we presented a case diagnosed with NV, who presented with tender, erythematous, eroded plaques with hemorrhagic-purulent discharge on both legs during treatment with dapagliflozin (an SGLT2i).
1945年,Montgomery首次提到结节性血管炎(结节性血管炎,NV)为硬膜红斑样病变(1)。NV是一种罕见的全身血管炎,通常局限于小腿。NV以斑块和红斑结节为特征,偶尔会出现溃疡和引流。它被认为是一种与许多致病因素相关的反应性疾病(2)。在以前的研究中报道的一些NV的感染性病因是结核病、诺卡菌、镰刀菌、假单胞菌、衣原体和丙型肝炎病毒(3-5)。一些病例也被发现与非感染性疾病有关,如药物(6,7)、炎症性肠病(8)、几种自身免疫性疾病(9)和罕见的恶性疾病(10,11)。钠-葡萄糖共转运蛋白-2抑制剂(SGLT2i)是一种口服降糖药。1945年,Montgomery首次发现结节性血管炎(NV)是一种罕见的泛膜炎,特别局限于小腿。NV以斑块和红斑结节为特征,常表现为溃疡和引流。它是一种反应性疾病,与许多致病因素有关。一些由感染性或非感染性致病因素引起的NV病例已被报道,但尚未有因钠-葡萄糖共转运蛋白-2抑制剂(SGLT2i)引起的NV病例的报道。在这个病例报告中,我们报告了一个被诊断为NV的病例,在使用达格列净(SGLT2i)治疗期间,他的双腿出现了触痛、红斑、侵蚀斑块和出血性脓性分泌物。
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引用次数: 1
MTHFR C677T Polymorphism in Turkish Women with Polycystic Ovary Syndrome 土耳其多囊卵巢综合征妇女的MTHFR C677T多态性
IF 0.2 Q4 Medicine Pub Date : 2021-01-01 DOI: 10.25179/TJEM.2020-78794
S. Polat, Y. Şimşek
Objective: Polycystic ovary syndrome (PCOS) is one of the most common endocrine-reproductive-metabolic disorders of women at reproductive age, affecting 5-15% of the women worldwide. Although the pathogenesis of PCOS is not well defined, it is associated with an increased risk of premature coronary artery disease (CAD). Hyperhomocysteinemia (HHcy) is associated with hyperlipidemia and is an independent risk factor for CAD. The most common cause of HHcy is related to the deficiency of methylenetetrahydrofolate reductase (MTHFR). This study aimed to investigate the relationship between different genotypes of MTHFR C677T and the risk of PCOS. Material and Methods: Two hundred twenty voluntary premenopausal women (110 healthy controls and 110 PCOS patients) were included in the study. All the volunteers underwent a physical examination along with biochemical hormonal evaluation and genetic analysis. Results: The genotyping analyses and genetic model of inheritance analyses revealed that the frequencies of CC, CT, and TT genotypes in the control and PCOS group to be 51.8%, 45.5%, and 2.7% and 51.8%, 48.2%, and 0%, respectively. The frequency of C and T alleles in the control and PCOS group was determined to be 74% (C: 0.74/155) and 26% (T: 0.26/53), and 75% (C: 0.75/167) and 25% (T: 0.25/53), respectively. The “T” additive, “T” dominant, and “C” recessive models it found that the CT vs. CC (OR:1.06 Cl:0.62-1.83), CC vs. TC+TT (OR: 0.99 Cl: 0.58-1.72), and TC+TT vs. CC (OR: 0.99 Cl: 0.58-1.70), respectively, did not show an increase in the PCOS risk. Conclusion: Our findings indicated that the different genotypes of MTHFR C677T were not associated with the risk of PCOS in Turkish women from Central Anatolia.
目的:多囊卵巢综合征(Polycystic ovarian syndrome, PCOS)是育龄期女性最常见的内分泌生殖代谢疾病之一,全世界约有5-15%的女性患有多囊卵巢综合征。虽然多囊卵巢综合征的发病机制尚不明确,但它与过早冠状动脉疾病(CAD)的风险增加有关。高同型半胱氨酸血症(HHcy)与高脂血症相关,是冠心病的独立危险因素。HHcy最常见的病因与亚甲基四氢叶酸还原酶(MTHFR)缺乏有关。本研究旨在探讨MTHFR C677T不同基因型与PCOS发病风险的关系。材料与方法:220名自愿绝经前妇女(健康对照110名,多囊卵巢综合征患者110名)纳入研究。所有志愿者都接受了身体检查、生化激素评估和基因分析。结果:基因分型分析和遗传分析的遗传模型显示,对照组和PCOS组CC、CT和TT基因型的频率分别为51.8%、45.5%和2.7%,51.8%、48.2%和0%。对照组和PCOS组C和T等位基因的频率分别为74% (C: 0.74/155)和26% (T: 0.26/53), 75% (C: 0.75/167)和25% (T: 0.25/53)。“T”加性、“T”显性和“C”隐性模型发现,CT与CC (OR:1.06 Cl:0.62-1.83)、CC与TC+TT (OR: 0.99 Cl: 0.58-1.72)和TC+TT与CC (OR: 0.99 Cl: 0.58-1.70)分别未显示PCOS风险增加。结论:我们的研究结果表明,MTHFR C677T的不同基因型与来自安纳托利亚中部的土耳其妇女患PCOS的风险无关。
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Turkish Journal of Endocrinology and Metabolism
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