G. Ayvaz, E. Akarsu, R. Attanasio, L. Hegedűs, E. Nagy, E. Papini, P. Perros
{"title":"The Use of Thyroid Hormones in Hypothyroid and Euthyroid Patients: A THESIS* Questionnaire Survey of Turkish Physicians","authors":"G. Ayvaz, E. Akarsu, R. Attanasio, L. Hegedűs, E. Nagy, E. Papini, P. Perros","doi":"10.5152/tjem.2022.22024","DOIUrl":"https://doi.org/10.5152/tjem.2022.22024","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"51 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81285211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Musadiq Adil Sheikh, A. Parry, Feroze A. Shaheen, M. Ganie, N. Choh, A. Bhat
{"title":"Effectiveness of Cabergoline in Reduction of Tumor Volume and Suppression of Prolactin in Treatment-Naive Prolactinomas and the Correlation of T2-weighted Signal Characteristics of Adenomas with Their Response to Treatment","authors":"Musadiq Adil Sheikh, A. Parry, Feroze A. Shaheen, M. Ganie, N. Choh, A. Bhat","doi":"10.5152/tjem.2022.22039","DOIUrl":"https://doi.org/10.5152/tjem.2022.22039","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"5 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81760920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Turgut, H. Pişkinpaşa, Didem Acarer Bugun, O. Karaarslan, E. Bozkur, N. Pamuk, İ. Cakir, M. Mert, S. Çiftçi Doğanşen
Objective: The aim of this study is to examine and compare the anxiety level and stress perception of acromegaly patients with controlled and active disease in the coronavirus disease 2019 pandemic. Methods: A total of 49 (23 females/26 males) patients applied to the outpatient clinic during the month after the first lockdown of the pandemic period were recruited in this cross-sectional study. State-Trait Anxiety Inventory (S-Anxiety for state scale, T-Anxiety for trait scale) and Perceived Stress Scale-14 were used to evaluate the event-related current state anxiety, the general tendency to anxiety, and perceived stressful situations. Patients were divided into 2 groups as active (n = 14) and well controlled (n = 35) patient groups and compared. Results: The active acromegaly group had significantly higher scores than well-controlled patients on all the S-Anxiety (P = .011), T-Anxiety (P = .002), and Perceived Stress Scale-14 (P = .007) scores after controlling for age, gender, body mass index, education years, marital and occupation status, disease duration, and disease-specific medical treatment status covariates. S-Anxiety (P = .021), T-Anxiety (P = .004), and Perceived Stress Scale-14 (P = .009) scores were found significantly higher in single patients than in married ones. Conclusion: This study showed significantly increased anxiety and perceived stress levels after the first lockdown of the coronavirus disease 2019 pandemic, especially in the active and single acromegaly patients compared to the well-controlled and married ones. Psychiatric symptoms should be carefully evaluated in the follow-up of acromegaly patients. The necessary psychological support should be provided to patients by focusing on these symptoms to improve patient management, particularly in a health-related stressful situation such as the coronavirus disease 2019 pandemic.
{"title":"Evaluation of Anxiety and Perceived Stress Levels in Patients with Acromegaly After the First Lockdown of the Coronavirus Disease 2019 Pandemic","authors":"S. Turgut, H. Pişkinpaşa, Didem Acarer Bugun, O. Karaarslan, E. Bozkur, N. Pamuk, İ. Cakir, M. Mert, S. Çiftçi Doğanşen","doi":"10.5152/tjem.2022.21995","DOIUrl":"https://doi.org/10.5152/tjem.2022.21995","url":null,"abstract":"Objective: The aim of this study is to examine and compare the anxiety level and stress perception of acromegaly patients with controlled and active disease in the coronavirus disease 2019 pandemic. Methods: A total of 49 (23 females/26 males) patients applied to the outpatient clinic during the month after the first lockdown of the pandemic period were recruited in this cross-sectional study. State-Trait Anxiety Inventory (S-Anxiety for state scale, T-Anxiety for trait scale) and Perceived Stress Scale-14 were used to evaluate the event-related current state anxiety, the general tendency to anxiety, and perceived stressful situations. Patients were divided into 2 groups as active (n = 14) and well controlled (n = 35) patient groups and compared. Results: The active acromegaly group had significantly higher scores than well-controlled patients on all the S-Anxiety (P = .011), T-Anxiety (P = .002), and Perceived Stress Scale-14 (P = .007) scores after controlling for age, gender, body mass index, education years, marital and occupation status, disease duration, and disease-specific medical treatment status covariates. S-Anxiety (P = .021), T-Anxiety (P = .004), and Perceived Stress Scale-14 (P = .009) scores were found significantly higher in single patients than in married ones. Conclusion: This study showed significantly increased anxiety and perceived stress levels after the first lockdown of the coronavirus disease 2019 pandemic, especially in the active and single acromegaly patients compared to the well-controlled and married ones. Psychiatric symptoms should be carefully evaluated in the follow-up of acromegaly patients. The necessary psychological support should be provided to patients by focusing on these symptoms to improve patient management, particularly in a health-related stressful situation such as the coronavirus disease 2019 pandemic.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"47 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81362062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Bilen, H. Bilen, Esra Gungor Albayrak, Y. Karadeniz, N. Gokkaya
{"title":"Postpartum Lactation Failure Secondary to Isolated Prolactin Deficiency: A Case Report and Literature Review","authors":"A. Bilen, H. Bilen, Esra Gungor Albayrak, Y. Karadeniz, N. Gokkaya","doi":"10.5152/tjem.2022.22048","DOIUrl":"https://doi.org/10.5152/tjem.2022.22048","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"107 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81051636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aasim N. Maldar, Phulrenu H. Chauhan, M. Lala, R. Deshpande
A 53-year-old, non-diabetic lady was evaluated for worsening breathlessness over the past 1 year. She was diagnosed with a lung lesion a year ago, but the prevailing COVID-19 situation prevented her from seeking further evaluation. She began to have early morning episodes of symptomatic hypoglycemia over the previous 4 months, which were relieved with dextrose infusions. The evaluation showed low insulin, low C-peptide, and high insulin-like growth factor-2 to insulin-like growth factor-1 ratio. High-resolution computed tomography scan of the thorax showed a 19.5 cm x 16.6 cm x 23.8 cm mass in the left hemithorax, and a microscopic examination of a biopsy specimen of which was consistent with the diagnosis of solitary fibrous tumor. The patient underwent sternotomy with left anterior thoracotomy with successful excision of the fibrous tumor. Post-operatively, histopathological diagnosis of solitary fibrous tumor was confirmed. There were no further episodes of hypoglycemia, and the patient was completely recovered.
一位53岁的非糖尿病女性在过去一年中因呼吸困难恶化而被评估。一年前，她被诊断出肺部病变，但目前的COVID-19形势使她无法寻求进一步的评估。在过去的4个月里，她开始有清晨发作的症状性低血糖，经葡萄糖输注缓解。评价结果显示低胰岛素，低c肽，高胰岛素样生长因子-2与胰岛素样生长因子-1比值。胸部高分辨率计算机断层扫描显示左半胸有一个19.5 cm x 16.6 cm x 23.8 cm的肿块，活检标本的显微镜检查与孤立性纤维性肿瘤的诊断一致。病人接受了胸骨切开术和左前胸切开术，成功切除了纤维性肿瘤。术后病理确诊为孤立性纤维性肿瘤。再无低血糖发作，患者完全康复。
{"title":"Late-Onset Non-islet Cell Tumor Hypoglycemia Associated with a Pleural Solitary Fibrous Tumor","authors":"Aasim N. Maldar, Phulrenu H. Chauhan, M. Lala, R. Deshpande","doi":"10.5152/tjem.2022.22021","DOIUrl":"https://doi.org/10.5152/tjem.2022.22021","url":null,"abstract":"A 53-year-old, non-diabetic lady was evaluated for worsening breathlessness over the past 1 year. She was diagnosed with a lung lesion a year ago, but the prevailing COVID-19 situation prevented her from seeking further evaluation. She began to have early morning episodes of symptomatic hypoglycemia over the previous 4 months, which were relieved with dextrose infusions. The evaluation showed low insulin, low C-peptide, and high insulin-like growth factor-2 to insulin-like growth factor-1 ratio. High-resolution computed tomography scan of the thorax showed a 19.5 cm x 16.6 cm x 23.8 cm mass in the left hemithorax, and a microscopic examination of a biopsy specimen of which was consistent with the diagnosis of solitary fibrous tumor. The patient underwent sternotomy with left anterior thoracotomy with successful excision of the fibrous tumor. Post-operatively, histopathological diagnosis of solitary fibrous tumor was confirmed. There were no further episodes of hypoglycemia, and the patient was completely recovered.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"62 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76193213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Misgar, M. S. Baba, A. Bhat, A. Khawaja, M. I. Lone, M. Bashir, A. Wani
{"title":"A Giant Urinary Bladder Paraganglioma","authors":"R. Misgar, M. S. Baba, A. Bhat, A. Khawaja, M. I. Lone, M. Bashir, A. Wani","doi":"10.5152/tjem.2022.22054","DOIUrl":"https://doi.org/10.5152/tjem.2022.22054","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"7 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82100257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Şahin, T. Eşkazan, E. Çiçek, Y. Yagiz Ozogul, E. Durcan, C. Sulu, Hande Mefkure Ozkaya, A. I. Hatemi, P. Kadıoğlu
{"title":"The Association Between Somatostatin Receptor Ligand and Vitamin B12 in Patients with Acromegaly","authors":"S. Şahin, T. Eşkazan, E. Çiçek, Y. Yagiz Ozogul, E. Durcan, C. Sulu, Hande Mefkure Ozkaya, A. I. Hatemi, P. Kadıoğlu","doi":"10.5152/tjem.2022.22030","DOIUrl":"https://doi.org/10.5152/tjem.2022.22030","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"39 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79870510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.25179/TJEM.2020-80188
M. Kocabaş, Z. Yarar, İ. Çordan, M. Can, H. C. Burgucu, H. Aydemir, M. Karakose, M. Kulaksızoğlu, F. Karakurt
Introduction Nodular vasculitis (NV) was first mentioned by Montgomery in 1945 for erythema induratum-like lesions (1). NV is a rare form of panniculitis and is usually localized on the calves. Characterized by plaques and erythematous nodules, NV may occasionally show ulceration and draining. It is considered a reactive disease associated with many causative factors (2). Some of the infectious causereported in previous studies for NV are Tuberculosis, Nocardia, Fusarium, Pseudomonas, Chlamydia, and hepatitis C virus (3-5). Some cases of NV have also been found associated with non-infectious conditions such as drugs (6,7), inflammatory bowel diseases (8), several autoimmune diseases (9), and rare malignant diseases (10,11). Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are oral antidiabetic drugs that inNodular vasculitis (NV), first described by Montgomery in 1945 for erythema induratum-like lesions, is a rare form of panniculitis that is particularly localized on the calves. Characterized by plaques and erythematous nodules, NV may often show ulceration and draining. It is known as a reactive disease associated with many causative factors. Several NV cases due to infectious or non-infectious causative factors have been reported, but no case of NV due to sodium-glucose cotransporter-2 inhibitors (SGLT2i) has yet been reported. In this case report, we presented a case diagnosed with NV, who presented with tender, erythematous, eroded plaques with hemorrhagic-purulent discharge on both legs during treatment with dapagliflozin (an SGLT2i).
{"title":"A Case Report of Dapagliflozin-Induced Nodular Vasculitis","authors":"M. Kocabaş, Z. Yarar, İ. Çordan, M. Can, H. C. Burgucu, H. Aydemir, M. Karakose, M. Kulaksızoğlu, F. Karakurt","doi":"10.25179/TJEM.2020-80188","DOIUrl":"https://doi.org/10.25179/TJEM.2020-80188","url":null,"abstract":"Introduction Nodular vasculitis (NV) was first mentioned by Montgomery in 1945 for erythema induratum-like lesions (1). NV is a rare form of panniculitis and is usually localized on the calves. Characterized by plaques and erythematous nodules, NV may occasionally show ulceration and draining. It is considered a reactive disease associated with many causative factors (2). Some of the infectious causereported in previous studies for NV are Tuberculosis, Nocardia, Fusarium, Pseudomonas, Chlamydia, and hepatitis C virus (3-5). Some cases of NV have also been found associated with non-infectious conditions such as drugs (6,7), inflammatory bowel diseases (8), several autoimmune diseases (9), and rare malignant diseases (10,11). Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are oral antidiabetic drugs that inNodular vasculitis (NV), first described by Montgomery in 1945 for erythema induratum-like lesions, is a rare form of panniculitis that is particularly localized on the calves. Characterized by plaques and erythematous nodules, NV may often show ulceration and draining. It is known as a reactive disease associated with many causative factors. Several NV cases due to infectious or non-infectious causative factors have been reported, but no case of NV due to sodium-glucose cotransporter-2 inhibitors (SGLT2i) has yet been reported. In this case report, we presented a case diagnosed with NV, who presented with tender, erythematous, eroded plaques with hemorrhagic-purulent discharge on both legs during treatment with dapagliflozin (an SGLT2i).","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"50 1","pages":"129-132"},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85094464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.25179/TJEM.2020-78794
S. Polat, Y. Şimşek
Objective: Polycystic ovary syndrome (PCOS) is one of the most common endocrine-reproductive-metabolic disorders of women at reproductive age, affecting 5-15% of the women worldwide. Although the pathogenesis of PCOS is not well defined, it is associated with an increased risk of premature coronary artery disease (CAD). Hyperhomocysteinemia (HHcy) is associated with hyperlipidemia and is an independent risk factor for CAD. The most common cause of HHcy is related to the deficiency of methylenetetrahydrofolate reductase (MTHFR). This study aimed to investigate the relationship between different genotypes of MTHFR C677T and the risk of PCOS. Material and Methods: Two hundred twenty voluntary premenopausal women (110 healthy controls and 110 PCOS patients) were included in the study. All the volunteers underwent a physical examination along with biochemical hormonal evaluation and genetic analysis. Results: The genotyping analyses and genetic model of inheritance analyses revealed that the frequencies of CC, CT, and TT genotypes in the control and PCOS group to be 51.8%, 45.5%, and 2.7% and 51.8%, 48.2%, and 0%, respectively. The frequency of C and T alleles in the control and PCOS group was determined to be 74% (C: 0.74/155) and 26% (T: 0.26/53), and 75% (C: 0.75/167) and 25% (T: 0.25/53), respectively. The “T” additive, “T” dominant, and “C” recessive models it found that the CT vs. CC (OR:1.06 Cl:0.62-1.83), CC vs. TC+TT (OR: 0.99 Cl: 0.58-1.72), and TC+TT vs. CC (OR: 0.99 Cl: 0.58-1.70), respectively, did not show an increase in the PCOS risk. Conclusion: Our findings indicated that the different genotypes of MTHFR C677T were not associated with the risk of PCOS in Turkish women from Central Anatolia.
{"title":"MTHFR C677T Polymorphism in Turkish Women with Polycystic Ovary Syndrome","authors":"S. Polat, Y. Şimşek","doi":"10.25179/TJEM.2020-78794","DOIUrl":"https://doi.org/10.25179/TJEM.2020-78794","url":null,"abstract":"Objective: Polycystic ovary syndrome (PCOS) is one of the most common endocrine-reproductive-metabolic disorders of women at reproductive age, affecting 5-15% of the women worldwide. Although the pathogenesis of PCOS is not well defined, it is associated with an increased risk of premature coronary artery disease (CAD). Hyperhomocysteinemia (HHcy) is associated with hyperlipidemia and is an independent risk factor for CAD. The most common cause of HHcy is related to the deficiency of methylenetetrahydrofolate reductase (MTHFR). This study aimed to investigate the relationship between different genotypes of MTHFR C677T and the risk of PCOS. Material and Methods: Two hundred twenty voluntary premenopausal women (110 healthy controls and 110 PCOS patients) were included in the study. All the volunteers underwent a physical examination along with biochemical hormonal evaluation and genetic analysis. Results: The genotyping analyses and genetic model of inheritance analyses revealed that the frequencies of CC, CT, and TT genotypes in the control and PCOS group to be 51.8%, 45.5%, and 2.7% and 51.8%, 48.2%, and 0%, respectively. The frequency of C and T alleles in the control and PCOS group was determined to be 74% (C: 0.74/155) and 26% (T: 0.26/53), and 75% (C: 0.75/167) and 25% (T: 0.25/53), respectively. The “T” additive, “T” dominant, and “C” recessive models it found that the CT vs. CC (OR:1.06 Cl:0.62-1.83), CC vs. TC+TT (OR: 0.99 Cl: 0.58-1.72), and TC+TT vs. CC (OR: 0.99 Cl: 0.58-1.70), respectively, did not show an increase in the PCOS risk. Conclusion: Our findings indicated that the different genotypes of MTHFR C677T were not associated with the risk of PCOS in Turkish women from Central Anatolia.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"18 1","pages":"102-112"},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78253977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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