Luis Miguel Juárez-Salcedo, Luis Manuel González, Samir Dalia
Patients diagnosed with diffuse large B-cell lymphoma (DLBCL) have high cure rates with current treatment options including immuno-polychemotherapy. However, around 30% of cases do not respond or develop relapse disease. For this, it is necessary to search for new therapeutic options. In recent years, therapy using chimeric antigen receptor (CAR) T-cells has been a strategy for those patients with LBDCG in progression or relapse, although only 30–40% of cases achieve durable remissions. The programmed death-1 (PD-1) receptor regulates the T-cell-mediated immune response through binding to its ligands (PD-L1). Some tumor cells present high expression of PD-L1, which down-regulates T-cell activation. The beneficial antitumor activity of PD-1 and PD-L1 has been widely demonstrated in certain solid organ malignancies. However, their utility in the treatment of lymphomas is complex. To date, different clinical trials have demonstrated its usefulness as an innovative therapeutic alternative in these tumors. In this review article, we evaluate the literature on the role of the PD-1/PD-L1 pathway in DLBCL and describe future strategies involving these new anticancer agents in this lymphoid neoplasm.
{"title":"Immunotherapy for diffuse large B-cell lymphoma: current use of immune checkpoint inhibitors therapy","authors":"Luis Miguel Juárez-Salcedo, Luis Manuel González, Samir Dalia","doi":"10.3934/medsci.2023020","DOIUrl":"https://doi.org/10.3934/medsci.2023020","url":null,"abstract":"<abstract> <p>Patients diagnosed with diffuse large B-cell lymphoma (DLBCL) have high cure rates with current treatment options including immuno-polychemotherapy. However, around 30% of cases do not respond or develop relapse disease. For this, it is necessary to search for new therapeutic options. In recent years, therapy using chimeric antigen receptor (CAR) T-cells has been a strategy for those patients with LBDCG in progression or relapse, although only 30–40% of cases achieve durable remissions. The programmed death-1 (PD-1) receptor regulates the T-cell-mediated immune response through binding to its ligands (PD-L1). Some tumor cells present high expression of PD-L1, which down-regulates T-cell activation. The beneficial antitumor activity of PD-1 and PD-L1 has been widely demonstrated in certain solid organ malignancies. However, their utility in the treatment of lymphomas is complex. To date, different clinical trials have demonstrated its usefulness as an innovative therapeutic alternative in these tumors. In this review article, we evaluate the literature on the role of the PD-1/PD-L1 pathway in DLBCL and describe future strategies involving these new anticancer agents in this lymphoid neoplasm.</p> </abstract>","PeriodicalId":43011,"journal":{"name":"AIMS Medical Science","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135401068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Lekshmi, J. Stephen, M. Ojha, Sanath H. Kumar, M. Varela
The microorganism Staphylococcus aureus is a notorious causative agent of bacterial infection. The widespread presence of this pathogen has caused significant morbidity and mortality rates in clinical healthcare settings and communities. Due to its increasingly frequent recalcitrant nature towards clinically available antimicrobial agents, the bacterium poses a considerable public health crisis. A significant bacterial mechanism of antimicrobial agent resistance includes multidrug efflux pump systems. These antimicrobial efflux determinants translate into several large superfamilies of transporters that share related amino acid sequences, similarities in three-dimensional structures, modes of energization, and solute transport catalysis across the membrane. Because of their ubiquitous nature and functional role in virulence, these multidrug transporters make good targets for inhibition. This review briefly summarizes recent key findings regarding multidrug efflux activity and modulation in the MATE, SMR, and MFS transporters.
{"title":"Staphylococcus aureus antimicrobial efflux pumps and their inhibitors: recent developments","authors":"M. Lekshmi, J. Stephen, M. Ojha, Sanath H. Kumar, M. Varela","doi":"10.3934/medsci.2022018","DOIUrl":"https://doi.org/10.3934/medsci.2022018","url":null,"abstract":"The microorganism Staphylococcus aureus is a notorious causative agent of bacterial infection. The widespread presence of this pathogen has caused significant morbidity and mortality rates in clinical healthcare settings and communities. Due to its increasingly frequent recalcitrant nature towards clinically available antimicrobial agents, the bacterium poses a considerable public health crisis. A significant bacterial mechanism of antimicrobial agent resistance includes multidrug efflux pump systems. These antimicrobial efflux determinants translate into several large superfamilies of transporters that share related amino acid sequences, similarities in three-dimensional structures, modes of energization, and solute transport catalysis across the membrane. Because of their ubiquitous nature and functional role in virulence, these multidrug transporters make good targets for inhibition. This review briefly summarizes recent key findings regarding multidrug efflux activity and modulation in the MATE, SMR, and MFS transporters.","PeriodicalId":43011,"journal":{"name":"AIMS Medical Science","volume":"12 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89710104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Madden, B. Feldman, Shane Arishenkoff, G. Meneilly
Objective
Diabetes and sarcopenia often coexist in older adults, suggesting a possible bidirectional association. Available bedside measures of muscle mass consist of bedside ultrasound (MT, quadriceps muscle thickness) and Bioelectrical Impedance Analysis (BIA). We examined the association between ultrasound measures and BIA measures of muscle in older adults with measures of strength, performance and frailty in older adults with diabetes.
Design
Cross-sectional study.
Methods
81 subjects (age ≥ 65; mean age 80.8 ± 0.6 years, 27 women, 53 men) were recruited sequentially from geriatric medicine clinics. Each subject had Lean Body Mass (LBM, by BIA, in kg), grip strength, gait speed, Cardiovascular Health Study index (frailty) and MT (in cm) measured. All initial models were adjusted for biological sex.
Results
In our final parsimonious models, only MT (as opposed to LBM) showed a significant correlation with grip strength (Standardized β = 0.217 ± 0.078; p = 0.007) and frailty (Standardized β = 0.276 ± 0.109; p = 0.013). Neither MT or LBM showed a significant association with subject performance (gait speed).
Conclusions
Unlike BIA, bedside ultrasound measures of muscle thickness showed strong associations with both grip strength and frailty in the older adult population with diabetes, suggesting that bedside measures of MT might be a more clinically useful modality to assess muscularity in this patient population. Neither BIA or MT measures of subject muscularity showed any association with our performance indicator (gait speed).
{"title":"Bedside tests of muscle mass in older adults with Type 2 diabetes","authors":"K. Madden, B. Feldman, Shane Arishenkoff, G. Meneilly","doi":"10.3934/medsci.2022022","DOIUrl":"https://doi.org/10.3934/medsci.2022022","url":null,"abstract":"<abstract><sec> <title>Objective</title> <p>Diabetes and sarcopenia often coexist in older adults, suggesting a possible bidirectional association. Available bedside measures of muscle mass consist of bedside ultrasound (MT, quadriceps muscle thickness) and Bioelectrical Impedance Analysis (BIA). We examined the association between ultrasound measures and BIA measures of muscle in older adults with measures of strength, performance and frailty in older adults with diabetes.</p> </sec><sec> <title>Design</title> <p>Cross-sectional study.</p> </sec><sec> <title>Methods</title> <p>81 subjects (age ≥ 65; mean age 80.8 ± 0.6 years, 27 women, 53 men) were recruited sequentially from geriatric medicine clinics. Each subject had Lean Body Mass (LBM, by BIA, in kg), grip strength, gait speed, Cardiovascular Health Study index (frailty) and MT (in cm) measured. All initial models were adjusted for biological sex.</p> </sec><sec> <title>Results</title> <p>In our final parsimonious models, only MT (as opposed to LBM) showed a significant correlation with grip strength (Standardized β = 0.217 ± 0.078; p = 0.007) and frailty (Standardized β = 0.276 ± 0.109; p = 0.013). Neither MT or LBM showed a significant association with subject performance (gait speed).</p> </sec><sec> <title>Conclusions</title> <p>Unlike BIA, bedside ultrasound measures of muscle thickness showed strong associations with both grip strength and frailty in the older adult population with diabetes, suggesting that bedside measures of MT might be a more clinically useful modality to assess muscularity in this patient population. Neither BIA or MT measures of subject muscularity showed any association with our performance indicator (gait speed).</p> </sec></abstract>","PeriodicalId":43011,"journal":{"name":"AIMS Medical Science","volume":"15 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77664215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Understanding the psychological impact of the COVID-19 pandemic on university students","authors":"B. Kara","doi":"10.3934/medsci.2022001","DOIUrl":"https://doi.org/10.3934/medsci.2022001","url":null,"abstract":"<jats:p xml:lang=\"fr\" />","PeriodicalId":43011,"journal":{"name":"AIMS Medical Science","volume":"9 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78367411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Osmond C Ekwebelem, H. Onyeaka, Ismaeel Yunusa, T. Miri, Yahwedalu M. Onwuneme, Ayeni T. Eunice, A. Anyogu, Bright C Obi, N. Carol
Objectives A significant percentage of the population must be vaccinated to achieve herd immunity. Therefore the success of a vaccination program relies on the level of acceptance. This present study seeks to understand COVID-19 vaccine acceptance and hesitancy in Nigeria by assessing the public's willingness to get vaccinated. Study design This is a population-based cross-sectional study. Data were derived through a structured online survey. Methods A cross-sectional study was conducted among adult residents in Nigeria in March 2021 using a structured online questionnaire. The questionnaire surveyed participants' demographic characteristics and perception of COVID-19 and the COVID-19 vaccine. Descriptive statistics and inferential statistics using Chi-square, as well as univariable logistic regression to determine the factors associated with acceptance of COVID-19 vaccine was conducted. Results Of the 618 respondents, 272 (44%) reported being willing to get vaccinated. Interestingly, of the 346 (56%) respondents that would not take the COVID-19 vaccine, the highest marginal reasons for non-acceptance were lack of trust in the government 163 (47.1%), followed by the belief that the vaccine is not safe 67 (19.4%), and no enough information about the vaccine 49 (13.6%). In addition, male respondents and those with a university degree or above were statistically significantly more likely to accept a COVID-19 vaccine. Conclusion A considerable proportion of the study population is unwilling to receive a COVID-19 vaccine. This observation highlights the need for the government, public health officials, and advocacy groups to implement immediate awareness-raising measures to sway the public towards COVID-19 vaccine acceptance.
{"title":"Do we trust the government? Attributes of COVID-19 vaccine hesitancy and acceptance in Nigeria","authors":"Osmond C Ekwebelem, H. Onyeaka, Ismaeel Yunusa, T. Miri, Yahwedalu M. Onwuneme, Ayeni T. Eunice, A. Anyogu, Bright C Obi, N. Carol","doi":"10.3934/medsci.2022010","DOIUrl":"https://doi.org/10.3934/medsci.2022010","url":null,"abstract":"Objectives A significant percentage of the population must be vaccinated to achieve herd immunity. Therefore the success of a vaccination program relies on the level of acceptance. This present study seeks to understand COVID-19 vaccine acceptance and hesitancy in Nigeria by assessing the public's willingness to get vaccinated. Study design This is a population-based cross-sectional study. Data were derived through a structured online survey. Methods A cross-sectional study was conducted among adult residents in Nigeria in March 2021 using a structured online questionnaire. The questionnaire surveyed participants' demographic characteristics and perception of COVID-19 and the COVID-19 vaccine. Descriptive statistics and inferential statistics using Chi-square, as well as univariable logistic regression to determine the factors associated with acceptance of COVID-19 vaccine was conducted. Results Of the 618 respondents, 272 (44%) reported being willing to get vaccinated. Interestingly, of the 346 (56%) respondents that would not take the COVID-19 vaccine, the highest marginal reasons for non-acceptance were lack of trust in the government 163 (47.1%), followed by the belief that the vaccine is not safe 67 (19.4%), and no enough information about the vaccine 49 (13.6%). In addition, male respondents and those with a university degree or above were statistically significantly more likely to accept a COVID-19 vaccine. Conclusion A considerable proportion of the study population is unwilling to receive a COVID-19 vaccine. This observation highlights the need for the government, public health officials, and advocacy groups to implement immediate awareness-raising measures to sway the public towards COVID-19 vaccine acceptance.","PeriodicalId":43011,"journal":{"name":"AIMS Medical Science","volume":"29 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84951290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Folic Acid (FA) is an important nutritional element during pregnancy. It is B vitamin which is found in the natural and complementary source. Deficiency of FA during pregnancy leads to many maternal and fetal complications such as neural tube defect (NTD), birth defect, spontaneous abortion, and megaloblastic anemia. This study aims to assess the effectiveness of an educational session about FA on pregnant women's knowledge in the Kingdom of Saudi Arabia (KSA). Methods A quasi-experimental design was conducted on sixty-five pregnant women from the outpatient clinic in Yanbu General Hospital (YGH) using pre-test and post-test questionnaire to assess their FA knowledge. A purposeful sampling method was used to involve the study participants. All the findings were analyzed through SPSS. Descriptive statistic was used to first generate information about the study participants, after which a t-test was conducted. Results The participants had poor knowledge about FA before the session but the level was increased after the session with mean difference 5.49. Majority of the study participants 81.5% had knowledge that FA protects against NTD. While, 70% understood that FA is an important vitamin during pregnancy. There is a significant association between the age, income, working status, age of marriage, and knowledge of participants. Conclusions An educational session had good effect on pregnant women's knowledge. Health care providers and social media should play more active role to increase the knowledge of FA to pregnant women.
{"title":"The effectiveness of an educational session about folic acid on pregnant women's knowledge in Yanbu City, Kingdom of Saudi Arabia","authors":"Ahlam Al-Zahrani, Shorooq Al-Marwani","doi":"10.3934/medsci.2022019","DOIUrl":"https://doi.org/10.3934/medsci.2022019","url":null,"abstract":"Background Folic Acid (FA) is an important nutritional element during pregnancy. It is B vitamin which is found in the natural and complementary source. Deficiency of FA during pregnancy leads to many maternal and fetal complications such as neural tube defect (NTD), birth defect, spontaneous abortion, and megaloblastic anemia. This study aims to assess the effectiveness of an educational session about FA on pregnant women's knowledge in the Kingdom of Saudi Arabia (KSA). Methods A quasi-experimental design was conducted on sixty-five pregnant women from the outpatient clinic in Yanbu General Hospital (YGH) using pre-test and post-test questionnaire to assess their FA knowledge. A purposeful sampling method was used to involve the study participants. All the findings were analyzed through SPSS. Descriptive statistic was used to first generate information about the study participants, after which a t-test was conducted. Results The participants had poor knowledge about FA before the session but the level was increased after the session with mean difference 5.49. Majority of the study participants 81.5% had knowledge that FA protects against NTD. While, 70% understood that FA is an important vitamin during pregnancy. There is a significant association between the age, income, working status, age of marriage, and knowledge of participants. Conclusions An educational session had good effect on pregnant women's knowledge. Health care providers and social media should play more active role to increase the knowledge of FA to pregnant women.","PeriodicalId":43011,"journal":{"name":"AIMS Medical Science","volume":"47 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90613691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Petrungaro, E. Quartarone, L. Rigoli, P. Sciarrone
Sickle cell disease (SCD) is a common inherited condition in African, Caribbean, and Mediterranean countries. SCD is a hematologic disorder caused by a well-characterized point mutation in the β-globin gene, which produces an abnormal hemoglobin S that results in the sickling of red blood cells in deoxygenated conditions. Patients with SCD display a “hypercoagulation state” leading to an increased risk of severe venous and arterial thrombotic vascular events. Herein we report a case of severe thrombotic complications in a patient with SCD who showed high antiphospholipid antibodies (APA) levels during vascular occlusions.
{"title":"Prothrombotic role of antiphospholipid antibodies in a patient with sickle cell disease","authors":"A. Petrungaro, E. Quartarone, L. Rigoli, P. Sciarrone","doi":"10.3934/medsci.2022017","DOIUrl":"https://doi.org/10.3934/medsci.2022017","url":null,"abstract":"Sickle cell disease (SCD) is a common inherited condition in African, Caribbean, and Mediterranean countries. SCD is a hematologic disorder caused by a well-characterized point mutation in the β-globin gene, which produces an abnormal hemoglobin S that results in the sickling of red blood cells in deoxygenated conditions. Patients with SCD display a “hypercoagulation state” leading to an increased risk of severe venous and arterial thrombotic vascular events. Herein we report a case of severe thrombotic complications in a patient with SCD who showed high antiphospholipid antibodies (APA) levels during vascular occlusions.","PeriodicalId":43011,"journal":{"name":"AIMS Medical Science","volume":"56 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90701447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdominal pregnancy is very rare, with only a few gynecologists being fortunate to encounter it all through their professional careers. It makes up only 1% of all ectopic pregnancies but has very high perinatal and maternal mortality of 95% and 18% respectively. Hemorrhagic and infectious complications account for these. Removal of the placenta at laparotomy is a big dilemma as torrential bleeding may ensue.
Case
We report the case of an undergraduate teenager who was referred with features of septicemia and anemia following unsafe vaginal instrumentation by a patent medicine dealer (a person without formal training in pharmacy but sells orthodox medications on retail basis) in a bid to terminate an extrauterine pregnancy. Ultrasonography confirmed a nonviable abdominal pregnancy of 20 weeks.
Result
She had exploratory laparotomy with the evacuation of the dead fetus and successful complete removal of the placenta. Her postoperative recovery was uneventful.
Conclusion
In view of the grave complications like a pelvic abscess, disseminated intravascular coagulation and bowel obstruction that may accompany retention of the placenta in advanced abdominal pregnancy, optimal placental removal at surgery is recommended whenever feasible.
{"title":"Abdominal pregnancy—a diagnosis never to miss","authors":"V. Dinwoke, Michael Amara, Linda Uzo Amara","doi":"10.3934/medsci.2022015","DOIUrl":"https://doi.org/10.3934/medsci.2022015","url":null,"abstract":"<abstract><sec> <title>Background</title> <p>Abdominal pregnancy is very rare, with only a few gynecologists being fortunate to encounter it all through their professional careers. It makes up only 1% of all ectopic pregnancies but has very high perinatal and maternal mortality of 95% and 18% respectively. Hemorrhagic and infectious complications account for these. Removal of the placenta at laparotomy is a big dilemma as torrential bleeding may ensue.</p> </sec><sec> <title>Case</title> <p>We report the case of an undergraduate teenager who was referred with features of septicemia and anemia following unsafe vaginal instrumentation by a patent medicine dealer (a person without formal training in pharmacy but sells orthodox medications on retail basis) in a bid to terminate an extrauterine pregnancy. Ultrasonography confirmed a nonviable abdominal pregnancy of 20 weeks.</p> </sec><sec> <title>Result</title> <p>She had exploratory laparotomy with the evacuation of the dead fetus and successful complete removal of the placenta. Her postoperative recovery was uneventful.</p> </sec><sec> <title>Conclusion</title> <p>In view of the grave complications like a pelvic abscess, disseminated intravascular coagulation and bowel obstruction that may accompany retention of the placenta in advanced abdominal pregnancy, optimal placental removal at surgery is recommended whenever feasible.</p> </sec></abstract>","PeriodicalId":43011,"journal":{"name":"AIMS Medical Science","volume":"17 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86906091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Do Thi Ngoc Linh, Lâm Khánh, L. Dung, Nguyen Hong Ha, Tran Cao Son, N. M. Duc
Objective Arteriovenous malformations (AVMs) are aggressive diseases with a high tendency to recur. AVM treatment is complex, especially in the anatomically difficult head and neck region. This study analyzed correlations between extracranial head and neck AVM presentations and the frequency of recurrence. Methods We retrospectively assessed AVM recurrence among 55 patients with head and neck AVMs treated with embolization and resection between January 2008 and December 2015. Recurrence was defined as any evidence of AVM expansion following embolization and resection. Patient variables, including sex, age, AVM size, AVM location, stage, and treatment modalities, were examined for correlations with the recurrence of head and neck AVMs. Statistical analysis was performed using SPSS 20.0. Results A total of 55 patients with at least 6 months of follow-up following AVM treatment with embolization and surgical resection were enrolled in this study. During follow-up, 14 of 55 patients experienced recurrence (the long-term recurrence rate was 25.5%). Sex, stage, AVM size, and treatment modality were identified as independent predictors of recurrence. Recurrence was less likely following the treatment of lower-stage or smaller lesions and did not correlate with age or location. Conclusions AVMs of the head and neck are among the most challenging conditions to manage due to a high risk of recurrence. Early and total AVM resection is the best method for preventing recurrence.
{"title":"Recurrence after treatment of arteriovenous malformations of the head and neck","authors":"Do Thi Ngoc Linh, Lâm Khánh, L. Dung, Nguyen Hong Ha, Tran Cao Son, N. M. Duc","doi":"10.3934/medsci.2022003","DOIUrl":"https://doi.org/10.3934/medsci.2022003","url":null,"abstract":"Objective Arteriovenous malformations (AVMs) are aggressive diseases with a high tendency to recur. AVM treatment is complex, especially in the anatomically difficult head and neck region. This study analyzed correlations between extracranial head and neck AVM presentations and the frequency of recurrence. Methods We retrospectively assessed AVM recurrence among 55 patients with head and neck AVMs treated with embolization and resection between January 2008 and December 2015. Recurrence was defined as any evidence of AVM expansion following embolization and resection. Patient variables, including sex, age, AVM size, AVM location, stage, and treatment modalities, were examined for correlations with the recurrence of head and neck AVMs. Statistical analysis was performed using SPSS 20.0. Results A total of 55 patients with at least 6 months of follow-up following AVM treatment with embolization and surgical resection were enrolled in this study. During follow-up, 14 of 55 patients experienced recurrence (the long-term recurrence rate was 25.5%). Sex, stage, AVM size, and treatment modality were identified as independent predictors of recurrence. Recurrence was less likely following the treatment of lower-stage or smaller lesions and did not correlate with age or location. Conclusions AVMs of the head and neck are among the most challenging conditions to manage due to a high risk of recurrence. Early and total AVM resection is the best method for preventing recurrence.","PeriodicalId":43011,"journal":{"name":"AIMS Medical Science","volume":"130 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87640922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical pharmacology is a multidisciplinary function playing a critical role in the monoclonal antibody development. Besides the requirements of understanding pharmacology, pharmacokinetics, model simulation, biostatistics and immunogenicity, wisely implementation of tactics and strategies to fulfill the agencies' requirements per guidance documents are critical. In this review, clinical pharmacology studies categorized as required, target dependent, development strategy dependent, and not usually needed are discussed. The review ends with the outlook of recent initiations in the clinical pharmacology such as the application of QSP with the integration of AI and machine learning technologies.
{"title":"Clinical pharmacology to support monoclonal antibody drug development","authors":"Sharon Lu","doi":"10.3934/medsci.2022014","DOIUrl":"https://doi.org/10.3934/medsci.2022014","url":null,"abstract":"Clinical pharmacology is a multidisciplinary function playing a critical role in the monoclonal antibody development. Besides the requirements of understanding pharmacology, pharmacokinetics, model simulation, biostatistics and immunogenicity, wisely implementation of tactics and strategies to fulfill the agencies' requirements per guidance documents are critical. In this review, clinical pharmacology studies categorized as required, target dependent, development strategy dependent, and not usually needed are discussed. The review ends with the outlook of recent initiations in the clinical pharmacology such as the application of QSP with the integration of AI and machine learning technologies.","PeriodicalId":43011,"journal":{"name":"AIMS Medical Science","volume":"37 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84669711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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