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COMPARISON OF IN VIVO CYANIDE EXAMINATION WITH PICRIC ACID AND PRUSIAN BLUE METHODS 用苦味酸法和普鲁士蓝法进行体内氰化物检测的比较
Pub Date : 2023-07-26 DOI: 10.46799/jhs.v4i7.1007
Mardhatillah Marsa, Hendro Widagdo, S. Suhartini
This study aims to determine the comparison of invivo cyanide examination by comparing the Pyric Acid method with the Blue Prusian method in the stomachs of experimental animals. It is an imental expre research. Samples of 40 white Wistar rats weighed between 100-200 g. Then the 40 rats were given lethal dose cyanide orally and divided into 2 groups: 1 group will be detected cyanide by picric acid method and 1 other group using blue prusian method. In such groups are taken gastric tissue. Consecutive examination time intervals on days 1 and 7. The results of cyanide examination with the Picric Acid method were obtained on day 1 of positive gastric tissue cyanide 94.7%, while with the Blue Prusian method on day 1 examination positive cyanide 85%. The results of cyanide examination with the PikraAcid t method on day 7 found that the gastric tissue was positive for cyanide 36.8%, while with the Blue Prusian method 35%. Both methods showed high sensitivity to cyanide examination in the gastric postmortem (P<0.05).
本研究旨在通过比较实验动物胃中的吡啶酸法和蓝普鲁士法,确定体内氰化物检查的比较。这是一项体外检测研究。然后给这 40 只大鼠口服致死剂量的氰化物,并将其分为两组:一组用苦味酸法检测氰化物,另一组用蓝普鲁士法检测氰化物。这两组均抽取胃组织。连续检查时间间隔为第 1 天和第 7 天。用苦味酸法进行氰化物检查的结果是,第 1 天胃肠组织氰化物阳性率为 94.7%,而用蓝普鲁士法进行氰化物检查的结果是,第 1 天胃肠组织氰化物阳性率为 85%。第 7 天使用苦味酸法进行氰化物检测的结果显示,胃组织氰化物阳性率为 36.8%,而使用蓝普鲁士法的阳性率为 35%。两种方法都显示出对胃部尸检氰化物检查的高灵敏度(P<0.05)。
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引用次数: 0
PENGARUH PEMBERIAN CRYOTHERAPY BERBASIS MODEL KONSEPTUAL LEVINE TERHADAP NYERI DAN KEKUATAN OTOT PASIEN POST OPERASI FRAKTUREKSTREMITAS BAWAH DI RSUD BAHTERAMAS SULTRA 基于莱文概念模型的冷冻疗法对 RSUD BAHTERAMAS SULTRA 下肢骨折术后患者疼痛和肌肉力量的影响
Pub Date : 2023-07-26 DOI: 10.46799/jhs.v4i7.1000
Erman Erman
Fraktur merupakan gangguan lengkap dan tidak lengkap dalam suatu stuktur tulang sesuai pada jenis dan luasnya struktur tulang tersebut. Fraktur disebabkan karena tulang mengalami stress yang besar daripada yang dapat diserap oleh struktur tulang tersebut. Ketika tulang patah, struktur tetangga di sekitar tulang mungkin terpengaruh, mengakibatkan edema jaringan lunak, perdarahan sendi dan otot, ruptur tendon, dislokasi sendi, dan putusnya saraf serta kerusakan pembuluh darah, Penelitian ini merupakan penelitian kuantitatif dengan desain quasi eksperiment dan pendekatan metode equivalent control group design. Sugiyono (2017: 107) mendefinisikan bahwa penelitian eksperimen yaitu penelitian yang digunakan untuk mencari pengaruh perlakuan tertentu terhadap yang lain dalam kondisi yang terkendali. Setelah intervensi dilakukan, peneliti langsung menilai pemulihan fraktur yang dirasakan oleh responden. Penilaian dilakukan dengan menggunakan Numeric Rating scale dan Manual Muscle Testing (MMT) yang diisi oleh peneliti berdasarkan hasil yang didapatkan dari responden setelah intervensi. Setelah mendapatkan skor hasil dari responden maka peneliti mengumpulkannya kembali dan data dianalisis untuk menentukan kesimpulan akhir dari penelitian ini.
根据骨结构的类型和程度,骨折是骨结构的完全或不完全破坏。当骨骼承受的压力超过骨结构所能承受的范围时,就会造成骨折。当骨骼断裂时,骨骼周围的邻近结构可能会受到影响,导致软组织水肿、关节和肌肉出血、肌腱断裂、关节脱位以及神经和血管损伤。 本研究是一项定量研究,采用准实验设计和等效对照组设计方法。Sugiyono(2017:107)定义,实验研究是在可控条件下,用于发现某些治疗方法对其他治疗方法的效果的研究。进行干预后,研究人员立即对受访者感受到的骨折恢复情况进行评估。评估使用的是研究人员根据受访者在干预后获得的结果填写的数字评级量表和徒手肌肉测试(MMT)。从受访者处获得分数后,研究人员将其收集回来,并对数据进行分析,以确定本研究的最终结论。
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引用次数: 0
IMPROVING ORAL HYGIENE STATUS IN CHILDREN WITH AUTISM SPECTRUM DISORDER IN BANDUNG THROUGH EDUCATION USING “TOOTH BRUSHING VISUAL PEDAGOGY” FLIPCHART 通过使用 "刷牙视觉教学法 "挂图进行教育,改善万隆自闭症谱系障碍儿童的口腔卫生状况
Pub Date : 2023-07-26 DOI: 10.46799/jhs.v4i7.1025
Josevinda Ayu Pramesti, Sri Susilawati, I. Sasmita
Background: Autism Spectrum Disorder (ASD) is characterized by social communication deficits and restricted interests. Children with ASD face challenges in oral health, necessitating education. Education with visual pedagogy using “Tooth Brushing Visual Pedagogy” flipchart can be used to improve dental health in ASD children. Purpose: This study examined the effectiveness of the "Tooth Brushing Visual Pedagogy" flipchart in improving oral hygiene among children with ASD at Biruku Indonesia Foundation. Methods: A quasi-experimental study with 14 participants measured the Patient Hygiene Performance (PHP) plaque index pre- and post-education. The flipchart was used, followed by a toothbrushing session Results: A significant improvement (p < 0.05) was observed (p-value = 0.000071). Before education, plaque index varied from excellent (0.0%) to poor (21.42%). After education, excellent and good oral hygiene increased (0.0% and 71.42%, respectively), while fair and poor levels decreased (28.57% and 0.0%, respectively). Conclusion: The "Tooth Brushing Visual Pedagogy" flipchart effectively improved oral hygiene among children with ASD.
背景:自闭症谱系障碍(ASD)的特点是社交沟通障碍和兴趣受限。自闭症谱系障碍儿童在口腔健康方面面临挑战,因此有必要开展教育。使用 "刷牙视觉教学法 "挂图进行视觉教学,可用于改善 ASD 儿童的牙齿健康。目的:本研究探讨了 "刷牙视觉教学法 "挂图在改善印度尼西亚比鲁库基金会 ASD 儿童口腔卫生方面的效果。研究方法一项由 14 名参与者参加的准实验研究测量了教育前后的患者卫生表现(PHP)牙菌斑指数。使用挂图,然后进行刷牙:观察到了明显的改善(p < 0.05)(p 值 = 0.000071)。教育前,牙菌斑指数从优(0.0%)到差(21.42%)不等。接受教育后,口腔卫生情况优秀和良好的比例上升(分别为 0.0% 和 71.42%),而一般和较差的比例下降(分别为 28.57% 和 0.0%)。结论刷牙视觉教学法 "挂图有效改善了 ASD 儿童的口腔卫生。
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引用次数: 0
SKIN CANCER IN CHILDREN WITH XERODERMA PIGMENTOSUM 色素性皮肤病儿童的皮肤癌
Pub Date : 2023-07-26 DOI: 10.46799/jhs.v4i7.1020
Maria Meildi, M. P. Soemitro, M. Abdurahman, Raden Yohana, K. Rizki, H. Usman
Introduction: Xeroderma pigmentosum) is a rare disease, inherited in an autosomal recessive manner with disturbances in the repair of deoxyribonucleic acid (DNA) which often occur in malignancy. Irreversible DNA lesions and mutations also occur in the genes which regulate skin cancer development in Xeroderma Pigmentosum. Purpose: To explain the signs, symptoms, and management of  skin cancer Xeroderma Pigmentosum. Case Report : A 6 year old girl with basal cell carcinoma arising from Xeroderma pigmentosum.  The histopathological picture of the left nasolabial biopsy preparation was found to show basal cell carcinoma (BCC). The patient was treated with 5FU administration and were followed after 6 week In the second patient, a 3 year old boy, squamous cell carcinoma in the oocipital area. From the histopathological picture, moderately differentiated squamous cell carcinoma on the left frontalis occipital dextra and corresponds to mottled hypermegrance on the parietal dextra. In this patient, a wide excision of the occipital lump was performed and the defect was closed with a full-thickness skin graft. Provided education to the parents of both patients for direct prevention of sun exposure by using sunscreen/hats. Discussion and Conclusion: Xeroderma Pigmentosum patients who are Xeroderma Pigmentosum  to ultraviolet radiation (UV) can result in the development of highly cancerous lesions consisting of squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and malignant melanoma (MM). Clinical management of Xeroderma Pigmentosum includes sun avoidance, minimizing UV eXeroderma Pigmentosumosure, early detection, skin lesions, and genetic counseling. Topical application of 5-fluorouracil or imiquimod is used for premalignant lesions, and surgical excision is performed for malignant neoplasms of the skin, tongue, eyelids, conjunctiva, and cornea.
简介色素沉着病(Xeroderma pigmentosum)是一种罕见的疾病,常染色体隐性遗传,脱氧核糖核酸(DNA)的修复发生障碍,常导致恶性肿瘤。在色素沉着病中,调节皮肤癌发生的基因也会发生不可逆的 DNA 损伤和突变。目的:解释色素性皮肤病皮肤癌的体征、症状和治疗方法。病例报告:一名 6 岁女孩,患有由色素性皮肤病引发的基底细胞癌。 左侧鼻唇活检组织病理照片显示为基底细胞癌(BCC)。患者接受了 5FU 治疗,并在 6 周后接受随访。 第二例患者是一名 3 岁男孩,眼眶部位出现鳞状细胞癌。从组织病理学图片来看,左额枕部右侧出现了中度分化的鳞状细胞癌,顶骨右侧则出现了斑驳的高色素沉着。对该患者进行了枕部肿块的广泛切除,并用全厚植皮缝合了缺损。对两名患者的父母进行教育,让他们使用防晒霜/帽子,直接预防阳光照射。讨论与结论:紫外线辐射(UV)可导致色素性皮肤病患者发生高度癌变,包括鳞状细胞癌(SCC)、基底细胞癌(BCC)和恶性黑色素瘤(MM)。色素性皮肤病的临床治疗包括避免日晒、尽量减少紫外线照射、早期发现皮肤病变和遗传咨询。局部使用 5-氟尿嘧啶或咪喹莫特治疗癌前病变,手术切除皮肤、舌头、眼睑、结膜和角膜的恶性肿瘤。
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引用次数: 0
THE ROLE OF SELF-EFFICACY MEDIATION IN INCREASING ORGANIZATIONAL CITIZENSHIP BEHAVIOR OF CLASS C PRIVATE HOSPITAL AT BEKASI 自我效能对提高勿加泗 C 级私立医院组织公民行为的中介作用
Pub Date : 2023-07-26 DOI: 10.46799/jhs.v4i7.1024
Gracesia Kwannandar, Rokiah Kusumapradja, Nofierni Nofierni
Organizational citizenship behavior is an important thing that must be considered by hospitals because it can affect overall organizational performance. The low voluntary behavior of helping each other among colleagues and the lack of teamwork and support among others can affect all processes in the workplace, both in terms of work productivity and organizational profitability. The purpose of this study was to analyze the effect of diversity in the workplace and organizational culture on organizational citizenship behavior with self-efficacy as a mediator. The role of self-efficacy can help overcome the obstacles associated with low organizational citizenship behavior, including low organizational culture and differences arising from diversity. This research is explanatory with a quantitative approach in the form of using causal hypotheses with a sample of 90 health workers. This study uses the SEM-PLS (Structural Equation Modeling-Partial Least Squares) method to examine the model and the relationship between variables. In this study, self-efficacy was found to mediate the relationship between organizational culture and diversity in the workplace and organizational citizenship behavior. Organizational culture has a positive and significant effect on organizational citizenship behavior, but diversity in the workplace does not have a significant effect on organizational citizenship behavior. Diversity in the workplace and organizational culture have a positive and significant influence on self-efficacy. The implications of this research theoretically prove the effect of research variables, and managerially, it can be used as an effective strategy to improve organizational citizenship behavior and create a good and productive work environment for health workers.
组织公民行为是医院必须考虑的一个重要问题,因为它会影响组织的整体绩效。同事之间互帮互助的自愿行为不高,其他人之间缺乏团队精神和支持,会影响工作场所的所有流程,既影响工作效率,也影响组织的盈利能力。本研究旨在以自我效能为中介,分析工作场所多样性和组织文化对组织公民行为的影响。自我效能感的作用有助于克服与低组织公民行为相关的障碍,包括低组织文化和多样性产生的差异。本研究采用定量方法,以因果假设为形式,以 90 名卫生工作者为样本,进行解释性研究。本研究采用 SEM-PLS(结构方程建模-部分最小二乘法)方法来检验模型和变量之间的关系。本研究发现,自我效能感是组织文化和工作场所多样性与组织公民行为之间关系的中介。组织文化对组织公民行为有积极而显著的影响,但工作场所的多样性对组织公民行为没有显著影响。工作场所的多样性和组织文化对自我效能感有积极而显著的影响。本研究的意义在理论上证明了研究变量的效果,在管理上,它可以作为一种有效的策略来改善组织公民行为,为卫生工作者创造一个良好的、富有成效的工作环境。
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引用次数: 0
KNOWLEDGE TO INCREASE NURSING WORK PERFORMANCE INPATIENT CARE: EMPIRICAL STUDY AT RSUD TAMANSARI 提高住院护理工作绩效的知识:RSUD TAMANSARI的实证研究
Pub Date : 2023-07-26 DOI: 10.46799/jhs.v4i7.1023
Mochammad Adam Eldi, Supriyantoro Supriyantoro, A. Adhikara
The hospital has the role of providing a holistic health care services. Nursing personnel makes up the largest proportion, which are almost 50% of all hospital human resources. The purpose of this study is to determine the effect analysis of motivation, workload and knowledge on the performance of nursing staff at RSUD Tamansari inpatient care. The method used in this study is cross sectional in the form of quantitative causality. Data collection used a survey method by taking questionnaires from 41 nurses in the inpatient unit of RSUD Tamansari. The sampling technique used in this study is total sampling. The analysis between variables using multiple linear regression test. The results showed that motivation and knowledge variables had a significant value of <0.05, while the workload variable had a significant value of >0.05. The research findings show that the dominant knowledge variable influences the performance of nursing staff inpatient care at RSUD Tamansari. The conclusion in this study is that motivation and knowledge have a direct and significant effect on the performance of nursing staff at inpatient care at RSUD Tamansari and workload does not have a direct and significant effect on the performance of nursing staff at inpatient care at RSUD Tamansari. One of the managerial implications is that hospital management and training units need to improve the education and training system as a priority.
医院的职责是提供全面的医疗保健服务。护理人员所占比例最大,几乎占医院人力资源的 50%。本研究的目的是确定动机、工作量和知识对 RSUD Tamansari 住院护理部护理人员绩效的影响分析。本研究采用的方法是定量因果关系形式的横断面研究。数据收集采用的是调查法,即向塔曼萨里研究与发展中心住院部的 41 名护士发放调查问卷。本研究采用的抽样技术是总体抽样。变量之间的分析采用多元线性回归检验。结果显示,动机和知识变量的显著值为 0.05。研究结果表明,占主导地位的知识变量影响着塔曼萨里研究与发展中心护理人员的住院护理绩效。本研究的结论是,动机和知识对塔曼萨里研究与发展中心住院护理部护理人员的绩效有直接和显著的影响,而工作量对塔曼萨里研究与发展中心住院护理部护理人员的绩效没有直接和显著的影响。其管理意义之一是,医院管理层和培训单位需要优先改善教育和培训系统。
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引用次数: 0
ANALYSIS OF HOSPITAL MANAGEMENT INFORMATION SYSTEM (SIMRS) AND ITS RELATION TO THE READINESS OF ELECTRONIC MEDICAL RECORD (RME) IMPLEMENTATION IN RSUP. SANGLAH DENPASAR 分析医院管理信息系统(SIMRS)及其与RSUP实施电子病历(RME)的准备程度的关系。巴厘岛
Pub Date : 2023-07-26 DOI: 10.46799/jhs.v4i7.1022
Putu Agus, Yoga Permana, Gusti Ayu, Eka Sutrisnawati, Ni Ketut, Juniati Rsup, Sanglah Denpasar, Ni
A hospital is a health service institution that provides plenary individual health services that provide inpatient, outpatient, and emergency services. This study focuses on the implementation of SIMRS using PIECES analysis where researchers assess SIMRS using six aspects, namely performance, information, economy, control, efficiency and service. Where the results of this system analysis aim to ascertain whether the system created has no error functions or the system is running properly. The method used in this analysis is the PIECES framework which includes 6 aspects of reference, namely: Performance, Information and data, Economics, Control and Security, Efficiency, and Service. This method is applied to calculate the level of user satisfaction with the system which later the results are used for evaluation of the system related to the development of system quality. Performance according to performance calculations in the PIECES analysis obtained a value of 3.96 with the predicate Satisfied, but there are several things that must be improved.
医院是提供住院、门诊和急诊服务的综合性医疗服务机构。本研究的重点是使用 PIECES 分析法评估 SIMRS 的实施情况,研究人员从六个方面对 SIMRS 进行评估,即绩效、信息、经济、控制、效率和服务。该系统分析的结果旨在确定所创建的系统是否没有错误功能或系统是否正常运行。分析中使用的方法是 PIECES 框架,该框架包括 6 个方面的参考,即性能、信息和数据、经济、控制和安全、效率和服务。该方法用于计算用户对系统的满意程度,计算结果将用于评估与系统质量发展相关的系统。根据 PIECES 分析中的性能计算,"满意 "谓词的值为 3.96,但仍有几处需要改进。
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引用次数: 0
DIABETIC FOOT: A SCOPING REVIEW OF NEUROSENSORIC DISORDERS – THERMOGRAPHY 糖尿病足:神经感觉障碍的范围审查 - 热成像技术
Pub Date : 2023-07-26 DOI: 10.46799/jhs.v4i7.1006
Lenny Nurhandayani, S. Andarini, Heri Kristianto
Background: Diabetic foot is a chronic complication that can be detrimental and has an impact on the quality of life of diabetic patients. Neurosensory examination of skin temperature using a thermograph can help prevent diabetic foot. Objective: to identify the neurosensory examination of skin temperature using infrared thermographs in addressing the risk of diabetic foot Design: The design in this study is Scoping review Methods: A journal search was conducted using the keywords "infrared thermography, screening or assessment, diabetic foot, and meta-analysis" to collect relevant articles published in the last ten years from four databases (ProQuest, PubMed, ScienceDirect, and Google Scholar). The inclusion criteria were: nurses, patients, diabetic foot, assessment, full-text articles, studies focusing on nursing issues, and written in English. Four journal articles were selected and analyzed using PICO. Results: Four meta-analysis articles on neurosensory examination of skin temperature sensitivity using a thermograph have a p value < 0.05, which can support clinical nursing for monitoring diabetic foot prevention. Conclusion: Examination of skin temperature sensation using a thermograph can be used as a method for neurosensory assessment in monitoring nursing care for structural integrity problems in the physiological changes of the diabetic foot.
背景:糖尿病足是一种慢性并发症,会对糖尿病患者的生活质量造成损害和影响。使用温度计对皮肤温度进行神经感觉检查有助于预防糖尿病足。目的:确定使用红外热成像仪对皮肤温度进行神经感觉检查在解决糖尿病足风险方面的作用:本研究采用范围综述的设计方法:使用关键词 "红外热成像、筛查或评估、糖尿病足和荟萃分析 "进行期刊检索,从四个数据库(ProQuest、PubMed、ScienceDirect 和 Google Scholar)中收集过去十年中发表的相关文章。纳入标准为:护士、患者、糖尿病足、评估、全文文章、关注护理问题的研究、英文撰写。筛选出四篇期刊论文,并使用 PICO 进行分析。结果:四篇关于使用温度计对皮肤温度敏感性进行神经感觉检查的荟萃分析文章的 P 值均小于 0.05,可为临床护理监测糖尿病足预防提供支持。结论使用热敏图检查皮肤温度敏感性可作为一种神经感觉评估方法,用于监测糖尿病足生理变化中结构完整性问题的护理。
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引用次数: 0
OVERVIEW OF THE LEVEL OF DEPRESSION, ANXIETY AND POSTOPERATIVE STRESS IN BONE TUMOR PATIENTS AT ORTHOPEDIC HOSPITAL PROF. DR. R. SOEHARSO SURAKARTA 苏腊卡尔塔市 R. Soeharso 教授骨科医院骨肿瘤患者抑郁、焦虑和术后压力水平概述
Pub Date : 2023-07-03 DOI: 10.46799/jhs.v4i7.998
Didit Triono, Aris Prayitno, Endang Winarni, Sri Mulyati, Nanda Wardhana
Bone tumors are abnormal cell growths that occur in bones. Although fairly rare, bone tumors are not an easily cured disease, the type of bone tumor that attacks many those aged 10-20 years is classified as an active and aggressive type of tumor. Because once attacked, the roots can gnaw the bone to require amputation, because if not, it will risk the safety of the patient's life. One treatment of bone tumors is surgery. But in the treatment of surgery, it is not uncommon for psychological problems to arise experienced by patients. Psychological problems that often arise when postoperative bone tumors it is depression, anxiety and stress. The purpose of this study was to determine the picture of the level of depression, anxiety and postoperative stress in bone tumor patients. This study used a Quantitative descriptive research design, the sampling technique used in this study was total sampling. The samples in this study were all preoperative bone tumor patients totaling 39 people. The instrument used is DASS. The results showed that respondents did not experience depression, namely as many as 27 people (69.2%), 7 people (17.9%) experienced mild depression and 5 people (12.8%) experienced moderate depression. Respondents with very severe anxiety, namely as many as 13 people (33.3%), then 12 people (30.8%) did not experience anxiety, then moderate anxiety levels, which were as many as 11 people (28.2%), very severe anxiety as many as 10 people (25.6%).
骨肿瘤是发生在骨骼中的异常细胞增生。骨肿瘤虽然相当罕见,但并不是一种容易治愈的疾病,许多 10-20 岁的人都会受到骨肿瘤的侵袭,这种类型的骨肿瘤被归类为活动性和侵袭性肿瘤。因为一旦发作,根部会啃噬骨头,需要截肢,否则会危及患者的生命安全。骨肿瘤的治疗方法之一是手术。但在手术治疗过程中,患者出现心理问题的情况并不少见。骨肿瘤术后经常出现的心理问题是抑郁、焦虑和压力。本研究旨在确定骨肿瘤患者的抑郁、焦虑和术后应激水平。本研究采用定量描述性研究设计,使用的抽样技术是总体抽样。本研究的样本为所有术前骨肿瘤患者,共计 39 人。使用的工具是 DASS。结果显示,受访者中没有抑郁症的有 27 人(69.2%),有轻度抑郁症的有 7 人(17.9%),有中度抑郁症的有 5 人(12.8%)。焦虑程度非常严重的受访者有 13 人(33.3%),没有焦虑的有 12 人(30.8%),焦虑程度中等的有 11 人(28.2%),焦虑程度非常严重的有 10 人(25.6%)。
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引用次数: 0
DEVELOPMENT OF TOOTHPASTE FORMULATION MODEL OF MANALAGI APPLE PEEL EXTRACT (Malus Sylvetris) WITH DIFFERENT CONCENTRATIONS AGAINST THE GROWTH OF STREPTOCOCCUS BACTERIA MUTANS IN VITRO AND IN VIVO 摘要建立了不同浓度苹果皮提取物体外、体内抗变形链球菌生长的牙膏配方模型
Pub Date : 2023-07-01 DOI: 10.46799/jhs.v4i7.996
RISMAN ABDI RAPIUDDIN
Background: Caries is a disease caused by damage to the enamel layer that can extend to the nerve part of the tooth. One way to prevent caries is to brush your teeth regularly using antibacterial herbal toothpaste that can reduce the number of colonies of streptococcus mutans bacteria. Apple peel is a useful herbal ingredient as an antibacterial, antioxidant, antifungal and antiproliferative, and polyphenolic compound. Objective: To determine the effect of developing a toothpaste formulation model of manalagi apple peel extract (malus sylvetris) with different concentrations on the growth of mutant Streptococcus bacteria in vitro and in vivo. Method: This study is a true experimental research using pre test and post test approach with control group design. Sampling was carried out using a simple random sampling technique and 15 respondents were obtained. This study was carried out for 3 days, where on the first day measurements were carried out (pretest) by taking saliva samples on respondents before brushing their teeth in the morning, and on the third day (posttest) measurements of respondents' saliva were carried out to test the bacterial colonies contained therein. Statistical analysis of Pre-Test Post-Test difference test using Paired T-Test difference test and One-Way Annova Test and Comparison Analysis with Post Hoc Tukey test. Results: This study showed that the dose of toothpaste in vitro testing was obtained the optimal dose, namely at the concentration of apple peel extract manalagi 25%, then in vivo tests the toothpaste formulation model of Manalagi apple peel extract (Malus Sylvetris) with the optimal dose (25%) was effective in inhibiting the growth of streptococcus mutans bacteria in vivo with an average decrease of -3.30 x 106 CFU / ml, with p value (0.005 < 0.05). control group + was -0.38 x 106 CFU/ml, and non-herbal toothpaste in control group - was -0.68 x 106 CFU/ml, but results Statistical analysis showed no significant difference in results before and after treatment in control group + (p value = 0.553 > 0.05) and control - (p value = 0.403 > 0.05). Conclusion: Manalagi apple peel extract toothpaste formulation model (malus sylvetris) with a concentration of 25% effective in inhibiting the growth of mutant Streptococcus bacteria in vitro and in vivo
& # x0D;& # x0D;& # x0D;& # x0D;& # x0D;& # x0D;& # x0D;& # x0D;& # x0D;& # x0D;& # x0D;& # x0D;& # x0D;背景:龋齿是一种由牙釉质层损伤引起的疾病,可扩展到牙齿的神经部分。预防龋齿的一种方法是定期使用抗菌草药牙膏刷牙,这种牙膏可以减少变形链球菌菌落的数量。苹果皮是一种有用的草药成分,具有抗菌、抗氧化、抗真菌、抗增殖和多酚化合物的作用。目的:研究不同浓度的苹果皮提取物(malus sylvetris)牙膏配方模型对突变链球菌体外和体内生长的影响。方法:本研究采用前测后测的方法,采用对照组设计,是一项真正的实验研究。抽样采用简单随机抽样方法,共获得15名受访者。这项研究进行了3天,其中第一天进行测量(前测),在早上刷牙前采集受访者的唾液样本,第三天(后测)测量受访者的唾液以测试其中所含的细菌菌落。采用配对t检验差异检验和单因素方差分析对前测后测差异检验进行统计分析,采用事后Tukey检验进行比较分析。结果:本研究表明,牙膏体外试验获得了最佳剂量,即马纳拉吉苹果皮提取物浓度为25%时的牙膏配方模型,体内试验表明,最佳剂量(25%)马纳拉吉苹果皮提取物(Malus Sylvetris)的牙膏配方模型有效抑制体内变形链球菌的生长,平均减少-3.30 × 106 CFU / ml, p值为(0.005 <0.05)。对照组+为-0.38 × 106 CFU/ml,对照组非中草药牙膏为-0.68 × 106 CFU/ml,但结果经统计学分析,对照组+治疗前后结果差异无统计学意义(p值= 0.553 >0.05)和对照组(p值= 0.403 >0.05)。结论:马纳拉木苹果皮提取物牙膏配方模型(malus sylvetris)以25%的浓度在体外和体内均能有效抑制突变链球菌的生长;& # x0D;& # x0D;& # x0D;& # x0D;& # x0D;& # x0D;& # x0D;& # x0D;& # x0D;& # x0D;& # x0D;& # x0D;
{"title":"DEVELOPMENT OF TOOTHPASTE FORMULATION MODEL OF MANALAGI APPLE PEEL EXTRACT (Malus Sylvetris) WITH DIFFERENT CONCENTRATIONS AGAINST THE GROWTH OF STREPTOCOCCUS BACTERIA MUTANS IN VITRO AND IN VIVO","authors":"RISMAN ABDI RAPIUDDIN","doi":"10.46799/jhs.v4i7.996","DOIUrl":"https://doi.org/10.46799/jhs.v4i7.996","url":null,"abstract":"&#x0D; &#x0D; &#x0D; &#x0D; &#x0D; &#x0D; &#x0D; &#x0D; &#x0D; &#x0D; &#x0D; &#x0D; &#x0D; Background: Caries is a disease caused by damage to the enamel layer that can extend to the nerve part of the tooth. One way to prevent caries is to brush your teeth regularly using antibacterial herbal toothpaste that can reduce the number of colonies of streptococcus mutans bacteria. Apple peel is a useful herbal ingredient as an antibacterial, antioxidant, antifungal and antiproliferative, and polyphenolic compound. Objective: To determine the effect of developing a toothpaste formulation model of manalagi apple peel extract (malus sylvetris) with different concentrations on the growth of mutant Streptococcus bacteria in vitro and in vivo. Method: This study is a true experimental research using pre test and post test approach with control group design. Sampling was carried out using a simple random sampling technique and 15 respondents were obtained. This study was carried out for 3 days, where on the first day measurements were carried out (pretest) by taking saliva samples on respondents before brushing their teeth in the morning, and on the third day (posttest) measurements of respondents' saliva were carried out to test the bacterial colonies contained therein. Statistical analysis of Pre-Test Post-Test difference test using Paired T-Test difference test and One-Way Annova Test and Comparison Analysis with Post Hoc Tukey test. Results: This study showed that the dose of toothpaste in vitro testing was obtained the optimal dose, namely at the concentration of apple peel extract manalagi 25%, then in vivo tests the toothpaste formulation model of Manalagi apple peel extract (Malus Sylvetris) with the optimal dose (25%) was effective in inhibiting the growth of streptococcus mutans bacteria in vivo with an average decrease of -3.30 x 106 CFU / ml, with p value (0.005 < 0.05). control group + was -0.38 x 106 CFU/ml, and non-herbal toothpaste in control group - was -0.68 x 106 CFU/ml, but results Statistical analysis showed no significant difference in results before and after treatment in control group + (p value = 0.553 > 0.05) and control - (p value = 0.403 > 0.05). Conclusion: Manalagi apple peel extract toothpaste formulation model (malus sylvetris) with a concentration of 25% effective in inhibiting the growth of mutant Streptococcus bacteria in vitro and in vivo&#x0D; &#x0D; &#x0D; &#x0D; &#x0D; &#x0D; &#x0D; &#x0D; &#x0D; &#x0D; &#x0D; &#x0D; &#x0D;","PeriodicalId":431769,"journal":{"name":"Jurnal Health Sains","volume":"160 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135852274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Jurnal Health Sains
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