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Functional Outcome in C2/C3 Fracture Dislocation Managed with Combined Surgical Decompression and Posterior Stabilization 联合手术减压和后路稳定治疗C2/C3骨折脱位的功能结局
Pub Date : 2023-05-26 DOI: 10.46799/jhs.v4i5.897
Teuku Nanta Aulia, Muhammad Iqbal, M irfan Guranda
Spinal cord injury is one of the main reasons for permanent paralysis and immobility till now. Spine injury is usually fatal because it involves more than one component, such as discoligamentous misconfiguration, vascular and spinal cord damage. Spine dislocation fracture at the level of C2-3 is rare and usually affects one or two vertebras. Good functional outcome in spine injury is uncommon in which death almost always happens suddenly or is caused by secondary trauma. Emergency room with a cervical spine injury. The patient was pushed by his friends from the side during playtime, causing the neck to hit the corner of a table. The dislocation fracture at the level of C2-3 and spinal cord compression directly caused tetraplegia. The condition was handled with a decompression procedure, spine fusion at the level of C1-4, and posterior stabilization with pedicle screws. A day after the operation, minimal movements were seen in both arms and legs, with motoric strength of 2/2/2/2. The score improved to 4/4/4/4 after two weeks of meds and physiotherapy. The patient started to write again in week 3. The dislocation fracture in this patient caused spinal cord compression. A retropulsion fracture fragment can be displaced to the spinal canal and potentially cause further spinal cord damage. Displacement towards the anterior horn leads to motoric dysfunction. Dislocation fracture at the level of C2-3 hinders neurotransmitter impulse, causing total paralysis on all extremities with intact sensory function. The patient had temporary external stabilization around the neck area while waiting for the procedure. The management concept in cases like this includes affected spinal cord decompression and internal fixation using pedicle screws to ensure fracture stabilization.
脊髓损伤是目前造成永久性瘫痪和行动不便的主要原因之一。脊柱损伤通常是致命的,因为它涉及不止一种成分,如双韧带错误配置,血管和脊髓损伤。脊柱脱位骨折在C2-3水平是罕见的,通常影响一个或两个椎体。脊柱损伤的良好功能预后并不常见,其死亡几乎总是突然发生或由继发性创伤引起。颈椎受伤的急诊室这名患者在玩耍时被他的朋友从旁边推了下来,导致脖子撞到了桌子的角上。C2-3水平脱位骨折和脊髓压迫直接导致四肢瘫痪。通过减压手术、C1-4节段脊柱融合术和椎弓根螺钉后路稳定治疗。术后1天,患者双臂和腿部均有轻微活动,运动强度为2/2/2。经过2周的药物和物理治疗后,评分提高到4/4/4/4。病人在第三周又开始写字了。该患者脱位骨折导致脊髓受压。后推性骨折碎片可移位至椎管,并可能导致进一步的脊髓损伤。前角移位导致运动功能障碍。C2-3水平的脱位骨折阻碍了神经递质冲动,导致感觉功能完好的四肢完全瘫痪。在等待手术期间,患者在颈部周围有暂时的外部稳定。此类病例的治疗理念包括受损脊髓减压和椎弓根螺钉内固定以确保骨折稳定。
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引用次数: 0
Autologus Platelet Rich Plasma (PRP) in Vitro Fertilization Antagonist Protocol Caused Homeobox A 10 (HOXA10) Expression in the Endometrium of Wistar Strained Rats Higher Than Without Autologous PRP 体外受精拮抗剂方案中自体富血小板血浆(PRP)引起Wistar拉伤大鼠子宫内膜同源盒a10 (HOXA10)表达高于无自体富血小板血浆(PRP)方案
Pub Date : 2023-05-25 DOI: 10.46799/jhs.v4i5.919
Putu A.A.N. Anantasika, Doster Mahayasa, I. Nyoman, Bayu Mahendra, I. Gede, M. Putra, Kadek Fajar, Dpg Jananuraga Maharddhika
Endometrial receptivity is highly correlated with the implantation rate, whereby in Indonesia, the implantation rate among in vitro fertilisation programs is still low, around 19.3%. Antagonist ovarian stimulation protocol can disrupt physiological endocrine milieu by the presence of supra-physiological levels of estrogen and progesterone, both of which are thought to indirectly affect the expression of adhesion molecule cells. Homeobox A 10 (HOXA10) is among one of the biomarkers used to assess endometrial receptivity. The role of HOXA10 is critical during the stage of endometrial development and embryo implantation, both in mice and human. This molecule is thought to work optimally by administering autologous platelet rich plasma (PRP) to the damaged endometrium. The aim of this study was to prove that administration of PRP in an antagonist protocol HOXA10 expression in the endometrium of Wistar rats higher than without PRP. This research was an experimental study. The design for this study was randomized posttest only controlled group, using female Wistar-strain rats type. A total of 40 Wistar rats whose ovary were stimulated by the GnRH antagonist protocol were divided into 2 groups, 20 rats as intervention group in which PRP administration was done and 20 rats as control group. It was found that during the study, there was no significant difference between intervention and control group regarding age and body weight of the Wistar rats, both at the start and at the end of the study. The results of HOXA10 H-score in the intervention group was 3.15 (2.86-3.52) and in the control group was 1.68 (1.43-2.18) (p <0.05). Administration of PRP to ovarian stimulation with an antagonist protocol showed significantly higher expression of endometrial HOXA10 in Wistar rats than without PRP administration.
子宫内膜容受性与着床率高度相关,因此在印度尼西亚,体外受精项目的着床率仍然很低,约为19.3%。拮抗剂卵巢刺激方案可以通过雌激素和孕激素的超生理水平的存在破坏生理内分泌环境,这两种物质被认为间接影响粘附分子细胞的表达。Homeobox a10 (HOXA10)是用于评估子宫内膜容受性的生物标志物之一。在小鼠和人类的子宫内膜发育和胚胎着床阶段,HOXA10的作用至关重要。该分子被认为通过将自体富血小板血浆(PRP)施用于受损子宫内膜而发挥最佳作用。本研究的目的是证明在拮抗剂方案中给予PRP的Wistar大鼠子宫内膜中HOXA10的表达高于未给予PRP的Wistar大鼠。这项研究是一项实验性研究。本研究设计为随机后验组,只设对照组,选用wistar系雌性大鼠型。将40只经GnRH拮抗剂方案刺激卵巢的Wistar大鼠分为2组,20只大鼠作为给予PRP的干预组,20只大鼠作为对照组。我们发现,在研究过程中,干预组和对照组Wistar大鼠在研究开始和结束时的年龄和体重均无显著差异。干预组HOXA10 H-score为3.15(2.86 ~ 3.52),对照组为1.68(1.43 ~ 2.18),差异有统计学意义(p <0.05)。在卵巢拮抗方案中给予PRP后,Wistar大鼠子宫内膜HOXA10的表达明显高于未给予PRP的大鼠。
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引用次数: 0
Hubungan Partus Lama dan Anemia dalam Kehamilan dengan Kejadian Atonia Uteri pada Ibu Bersalin
Pub Date : 2023-05-25 DOI: 10.46799/jhs.v4i5.882
Yuni Asmilawati, Ida Ayu Made Mahayani, Halia Wanadiatri, Adib Ahmad Shammakh
Atonia uteri is a state of weak tone or uterine contraction, which causes the uterus to be unable to close open bleeding from the site of placental implantation after the baby and placenta are born. Maternal mortality in Indonesia is still relatively high, one of the causes is postpartum bleeding, especially caused by uterine atonia. This study aims to find out the relationship of prolonged labor and anemia in pregnancy with the incidence of uterine atonia in women giving birth at the NTB Provincial Hospital. This study is observationally analytical using case-control design. The sampling technique is total sampling. The research sampel consisted of 60 samples with each case and control 30 samples that fit the inclusion and exclusion criteria. The data obtained were analyzed with the chi-square correlation test. The result of his study were obtained prolonged labor are 18(71,7%) and who were not prolonged labor 43 (71,7%). While respondents with anemia 34 (56,7%) and who were not anemia 26 (43,3%).There is relationship between prolonged labor with incidence of uterine atony in women giving birth with p-value 0,010 and with OR 4,971 more at risk of uterine atony and there is relationship between anemia in pregnancy with the incidence of uterine atony in women giving birth with p-value 0,037 and with OR 3,051more at risk of uterine atony. There is significant relationship between prolonged labor and anemia in pregnancy with the incidence of uterine atony in women giving birth in the NTB Provincial Hospital.
子宫弛缓是一种弱张力或子宫收缩的状态,导致胎儿和胎盘出生后,子宫无法关闭胎盘着床部位的开放出血。印度尼西亚的产妇死亡率仍然比较高,原因之一是产后出血,尤其是子宫张力过大引起的。本研究旨在探讨在NTB省医院分娩的产妇,妊娠期分娩时间延长及贫血与子宫张力的关系。本研究采用病例对照设计进行观察分析。抽样技术是全抽样。研究样本为每例60个样本,对照组为符合纳入和排除标准的30个样本。所得资料采用卡方相关检验进行分析。其研究结果为获得延长产程者18例(71.7%),未获得延长产程者43例(71.7%)。而贫血34人(56,7%)和非贫血26人(43,3%)。分娩时间延长与p值为0.010的产妇子宫张力发生率相关,OR值为4971的产妇子宫张力发生率相关;妊娠期贫血与p值为0.037的产妇子宫张力发生率相关,OR值为3051的产妇子宫张力发生率相关。在NTB省医院分娩的妇女中,延长分娩时间和妊娠期贫血与子宫张力的发生率有显著关系。
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引用次数: 0
Analisis Faktor yang Berhubungan dengan Penerapan Budaya Keselamatan Pasien pada Perawat 分析与护士的生存文化应用相关的因素
Pub Date : 2023-05-25 DOI: 10.46799/jhs.v4i5.899
Dewi Kuraesin, Rina Mutiara, Rokiah Kusumapradja
Patient safety culture is a product of values, attitudes, competencies and behavioral patterns of individuals and groups that determine the commitment, style and ability of a health care organization towards patient safety programs. if a health service organization does not have a patient safety culture, accidents can occur resulting in latent errors, psychological and physiological disturbances to staff, decreased productivity, reduced patient satisfaction and cause interpersonal conflicts. leadership, competence and effective communication are important factors for the successful implementation of patient safety culture in hospitals. Analyzing the relationship of leadership, competency and effective communication to the implementation of patient safety culture. This research was conducted on 179 nurses working in the inpatient room of the XX Serang hospital which were taken from 323 nurses, with the research method using cross-sectional research, where data was taken through interviews using questionnaire sheets. In this study the authors used statistical analysis of the Cji Square test and correlation test to determine the strength of the relationship between variables. Statistical test results obtained values for leadership variables 0.001, competence 0.000 and effective communication 0.017 < P value (0.05) so that it can be concluded that there is a significant relationship between leadership, competence and effective communication on the application of patient safety culture to nurses in inpatient rooms of XX hospital Attack. While the results of the correlation test obtained a coefficient value for leadership 0.25, competence 0.043 and effective communication 0.164, of the three independent variables, it is the leadership variable that has a higher value than the others, this shows that leadership plays a very high role in implementing patient safety culture to nurses in the inpatient room of the XX Serang Kata hospital
患者安全文化是个人和团体的价值观、态度、能力和行为模式的产物,它决定了医疗机构对患者安全项目的承诺、风格和能力。如果卫生服务组织没有患者安全文化,就可能发生事故,导致潜在的错误,对工作人员造成心理和生理上的干扰,降低生产力,降低患者满意度,并导致人际冲突。领导、能力和有效沟通是医院成功实施患者安全文化的重要因素。分析领导、胜任力和有效沟通对患者安全文化实施的关系。本研究对XX雪朗医院住院部的179名护士进行调查,这些护士来自323名护士,采用横断面研究的研究方法,采用问卷访谈的方式获取数据。在本研究中,作者使用统计分析的Cji平方检验和相关检验来确定变量之间的关系强度。统计检验结果显示,领导力变量的值为0.001,能力变量的值为0.000,有效沟通变量的值为0.017 <P值(0.05),得出XX医院住院室护士在患者安全文化的应用中,领导力、能力和有效沟通之间存在显著关系。而相关检验的结果得出领导力的系数值为0.25,能力的系数值为0.043,有效沟通的系数值为0.164,在三个自变量中,领导力的系数值高于其他变量,这表明领导力在XX雪朗卡塔医院住院病房护士实施患者安全文化方面发挥了非常高的作用
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引用次数: 0
Modified Foam Stability Test (Fs-50) as Predictor of Fetal Lung Maturity in Preterm Premature Rupture of Membrane Patients Given Dexamethasone Therapy 改良泡沫稳定性试验(Fs-50)在给予地塞米松治疗的胎膜早破患者中作为胎儿肺成熟度的预测指标
Pub Date : 2023-05-25 DOI: 10.46799/jhs.v4i5.906
Olivia Listiowati Prawoto, Tjokorda Gde, Agung Suwardewa, Putu Made Darmayasa, Doster Mahayasa, I. Nyoman, Bayu Mahendra, Evert Solomon, P. D. Mahayasa, Solomon Pangkahila
This study aims to determine the ability of the Modified Foam Stability (FS-50) test to predict fetal lung maturity in preterm premature rupture of membranes treated with Dexamethasone. The study sample included pregnant women with PROM at a gestational age of 24 to less than 34 weeks in the ER and Obstetrics Ward of Sanglah Central General Hospital, Denpasar. The patient underwent a vaginal speculum examination to collect fluid pooled in the vagina or from the outer cervical opening. Fluids are checked with the Modified Foam Stability (FS-50) test and graded from 0 to +4 to estimate fetal lung maturity. The first test was performed before Dexamethasone, followed by serial examinations at 12-hour intervals for 48 hours. Before dexamethasone injection, all patients got 0 scores as a baseline. There were statistically significant differences in FS-50 values before and after injection of the first, second, third, and fourth doses of Dexamethasone in PPROM patients. Fetal lung maturity was reached after the third dose of dexamethasone injection (36 hours after the first injection), characterized by an FS-50 value of > +3 and no asphyxia in the newborn. Spearman's rank analysis showed a significant correlation (p=0.005) between infants' maximum FS-50 value and asphyxia status. The FS-50 value > +3 is associated with the absence of asphyxia in infants born to PPROM patients who were given Dexamethasone for lung maturation. FS-50 can predict fetal lung maturity in preterm premature rupture of membranes given dexamethasone therapy.
本研究旨在确定改良泡沫稳定性(FS-50)试验对地塞米松治疗的早产儿胎膜早破胎儿肺成熟度的预测能力。研究样本包括登巴萨Sanglah Central General Hospital急诊室和产科病房24至34周的胎龄为早舞会的孕妇。患者行阴道窥镜检查,收集阴道内或宫颈外开口积液。用改良泡沫稳定性(FS-50)测试检查液体,并从0到+4分级,以估计胎儿肺成熟度。在使用地塞米松之前进行第一次检查,随后每隔12小时进行连续检查,持续48小时。注射地塞米松前,所有患者均以0分为基线。PPROM患者注射第1、2、3、4次地塞米松前后FS-50值差异有统计学意义。第三次地塞米松注射后(第一次注射后36 h)胎儿肺成熟,FS-50值> +3,新生儿无窒息。Spearman秩次分析显示,婴儿最大FS-50值与窒息状态之间存在显著相关(p=0.005)。FS-50值> +3与给予地塞米松促进肺成熟的PPROM患者所生婴儿无窒息相关。FS-50可以预测地塞米松治疗的早产胎膜早破胎儿肺成熟度。
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引用次数: 0
REVIEW ARTICLE: TERAPI FARMAKOLOGI MENINGITIS TUBERKULOSIS 综述文章:terapi农场细菌性脑膜炎结核
Pub Date : 2023-05-25 DOI: 10.46799/jhs.v4i5.892
Adira Rahmawaty
Meningitis Tuberkulosis (Meningitis TB) merupakan salah satu jenis TB ekstra paru yang sangat mematikan karena menginfeksi sistem saraf pusat. Oleh karena itu terapi farmakologi pasca ditegakkannya diagnosis sangat diperlukan untuk mempertahankan dan meningkatkan kualitas hidup pasien. Berdasarkan hal tersebut didapatkan 210 artikel yang berkaitan dengan kata kunci dan 15 artikel yang memenuhi kriteria inklusi. Terapi farmakologi utama untuk pasien dengan meningitis tuberkulosis diantaranya rifampisin, isoniazid, pirazinamid, etambutol, deksametason, dan antibiotik golongan sefalosporin golongan ketiga.
结核病是一种因感染中枢神经系统而具有高度致命的多肺结核病。因此,诊断后的药理学治疗对于维持和提高病人的生活质量是必不可少的。基于此,获得了210篇与关键词相关的文章和15篇符合条目标准的文章。结核病患者的主要药理学治疗包括射皮瘤、黄疸、二甲基苯丙胺、扑热息痛、棕榈醇、替莫托、德马科黄素和三类头孢菌抗生素。
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引用次数: 0
the Effect of Knowledge, Motivation, Organizational Culture on Medical Record Compliance Compliance in Hospitals 知识、动机、组织文化对医院病案合规的影响
Pub Date : 2023-05-25 DOI: 10.46799/jhs.v4i5.905
Suriviana Suriviana, Rokiah Kusumapradja, L. Widjaya
Every health service facility is required to make medical records made by doctors and health workers related to the services that have been provided. The completeness of the information provided by health workers shows that the quality of the health services provided can be proven to be following related health service standards. This study was to analyze the influence of knowledge, motivation, and organizational culture simultaneously on compliance with medical record filling at Mitra Medika Hospital Pontianak using 83 respondents using the mixed methods sequential explanatory designs. From the results of the quantitative research, it was found that the Knowledge and Organizational Culture variables influenced compliance with medical record filling with beta values ​​of 0.567 and 0.416; as well as the significance of both variables 0.000; Meanwhile, motivation does not affect compliance with medical record filling with a beta value of 0.003 and a significance of 0.940; Knowledge is the variable that has the most dominant influence on compliance with medical record filling. From the results of qualitative research, it was found that motivation does not affect the value of the dimensions of motivation. Where knowledge and organizational culture influence the filling of medical records by the values ​​of the dimensions of knowledge and organizational culture.
每个保健服务机构都必须提供医生和保健工作者所做的与所提供的服务有关的医疗记录。卫生工作者提供的信息的完整性表明,所提供的卫生服务的质量可以证明符合相关的卫生服务标准。本研究采用混合方法序贯解释设计,分析知识、动机和组织文化同时对Pontianak Mitra Medika医院病历填写依从性的影响。定量研究结果发现,知识和组织文化变量对病历填写依从性的影响贝塔值分别为0.567和0.416;以及两个变量的显著性0.000;同时,动机不影响病历填写依从性,beta值为0.003,显著性为0.940;知识是影响病历填写依从性的最主要变量。从定性研究的结果来看,我们发现动机并不影响动机各维度的价值。其中知识和组织文化通过知识和组织文化维度的价值影响病历的填写。
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引用次数: 0
The Impact of Anemia Prevention Health Counseling on Knowledge of Pregnant Women in Puskesmas 预防贫血健康咨询对Puskesmas孕妇知识的影响
Pub Date : 2023-05-25 DOI: 10.46799/jhs.v4i5.904
Ellen Pesak, J. Kristianto, Bongakaraeng Bongakaraeng, Johana Tuegeh, J. Kolompoy, Putri Nurul Firdaus
The World Health Organization (WHO) estimates that 35-70% of pregnant women in developing countries are anemic. Indonesia is one of the  developing countries  with  the highest incidence of anemia, which is around 70% in pregnant women.  One  of the causes of anemia during pregnancy  is that many pregnant women do not know the prevention of  anemia  during pregnancy. The purpose of this study was to determine the effect of  health counseling on the   prevention of anemia on the knowledge of   pregnant women. The research design used was pre-experimental with a one-group pretest-posttest  method where the characteristics of this design were no comparison group (control).  The study population was all pregnant women at the Minanga Health Center which amounted to 46 people. The sample technique used was simple random sampling, which was as many as 35 people. Analysis with Wilcoxon signed rank test.  The test results have a significant influence of health counseling on  anemia prevention  on the  knowledge of  pregnant women (α ≤ 0.05,  namely p-value = 0.000).    The conclusion is that health counseling on the prevention of anemia increases the knowledge of pregnant women. Suggestions are expected by the puskesmas to increase counseling or education about anemia  during pregnancy so that  pregnant women's  knowledge  about anemia increases. 
世界卫生组织(WHO)估计,发展中国家35-70%的孕妇患有贫血症。印度尼西亚是贫血发病率最高的发展中国家之一,孕妇的贫血发病率约为70%。怀孕期间贫血的原因之一是许多孕妇不知道怀孕期间贫血的预防。本研究的目的是确定健康咨询对孕妇预防贫血知识的影响。研究设计采用一组前测后测法进行预实验,该设计的特点是没有对照组(对照)。研究对象为米南加保健中心的46名孕妇。使用的样本技术是简单的随机抽样,最多有35人。用Wilcoxon符号秩检验分析。检验结果表明,预防贫血健康咨询对孕妇的认知有显著影响(α≤0.05,即p值= 0.000)。结论:健康咨询可提高孕妇对预防贫血的认识。建议增加孕期贫血的咨询或教育,提高孕妇对贫血的认识。
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引用次数: 0
High Serum Ratio of Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1) to Placental Growth Factor (PIGF) and High Level of Low-Density Lipoprotein (LDL) as Risk Factors of Preeclampsia 血清可溶性fms样酪氨酸激酶1 (sFlt-1)与胎盘生长因子(PIGF)比值高和低密度脂蛋白(LDL)水平高是子痫前期的危险因素
Pub Date : 2023-05-25 DOI: 10.46799/jhs.v4i5.920
Kevin Agastya Duarsa, Endang A.A.N. Jaya Kusuma, Sri Widiyanti, Putu Wayan Megadhana, Doster Mahayasa, R. Mulyana
Preeclampsia is an obstetric disease that is a health problem worldwide, including in Indonesia. Several studies have shown that changes in the maternal spiral arteries are thought to lead to preeclampsia. Preeclampsia in this decade has been associated with changes in angiogenesis regulatory proteins originating from the placenta and circulating in the mother's blood circulation, namely soluble FMS-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF). The author was interested in examining the ratio of sFlt-1/PIGF and low-density lipoprotein (LDL) to the incidence of preeclampsia in pregnant women. This study used a case control analytic observational design. The research sample was selected by consecutive sampling of 20 cases and 20 controls. Univariate analysis was used to describe patient characteristics descriptively, and bivariate analysis was used to determine the relationship between the 2 variables There is no significant difference in the characteristics of the research subjects. Low PIGF levels are a risk factor for preeclampsia (OR 4.33; p 0.0302) with a cut-off value of 24.5. High sFlt-1 levels are a risk factor for preeclampsia (OR 4.33; p 0.027) with a cut-off value of 869.5. A high sFlt-1/PIGF ratio is a risk factor for preeclampsia (OR 4.33 p 0.030) with a cut-off value of 38. High LDL levels are a risk factor for preeclampsia (OR 6.0; p 0.013) with a cut-off value of 150 ,2. Low placental growth factor (PIGF), high levels of soluble FMS-like tyrosine kinase 1 (sFlt-1), and high levels of LDL are risk factors of preeclampsia in pregnant women.
子痫前期是一种产科疾病,在全世界都是一个健康问题,包括在印度尼西亚。几项研究表明,母体螺旋动脉的变化被认为是导致子痫前期的原因。近十年来,先兆子痫与源自胎盘并在母亲血液循环中循环的血管生成调节蛋白的变化有关,即可溶性fms样酪氨酸激酶1 (sFlt-1)和胎盘生长因子(PlGF)。作者感兴趣的是检查sFlt-1/PIGF和低密度脂蛋白(LDL)在孕妇子痫前期发病率中的比例。本研究采用病例对照分析观察设计。研究样本采用20例病例和20例对照连续抽样的方法选取。采用单因素分析对患者特征进行描述性描述,采用双因素分析确定两变量之间的关系,研究对象的特征无显著差异。低PIGF水平是子痫前期的危险因素(OR 4.33;P 0.0302),临界值为24.5。高水平的sFlt-1是子痫前期的危险因素(OR 4.33;P 0.027),临界值为869.5。高sFlt-1/PIGF比值是子痫前期的危险因素(OR 4.33 p 0.030),临界值为38。高LDL水平是子痫前期的危险因素(OR 6.0;P 0.013),临界值为150,2。胎盘生长因子(PIGF)水平低、可溶性fms样酪氨酸激酶1 (sFlt-1)水平高、低密度脂蛋白(LDL)水平高是孕妇子痫前期的危险因素。
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引用次数: 0
ACCURACY OF CANCER ANTIGEN 125 AND ALBUMIN BEFORE OPERATION TO PREDICT THE OPERATION OUTCOME IN PATIENTS WITH ADVANCED STAGE EPITHELIAL TYPE OVARIAN CANCER 术前癌抗原125和白蛋白预测晚期上皮型卵巢癌手术预后的准确性
Pub Date : 2023-05-25 DOI: 10.46799/jhs.v4i5.928
B. Budiana, Bayu Mahendra, M. Putra, Harry Wijaya, A. Putra, Nathassa Karisma
Ovarian cancer is a malignancy that grows and develops in the ovaries with a high mortality rate. Primary debulking surgery (P.D.S.) is diagnostic and therapeutic and has become the standard option. CA-125 levels were increasing with the worsening disease conditions in ovarian cancer. In addition, preoperative albumin levels were strongly associated with worse ovarian cancer outcomes. This study assessed the prediction of CA-125 markers and albumin levels on P.D.S. outcomes. This research is a diagnostic test conducted at Prof. Dr I.G.N.G. Ngoerah Hospital. The study sample consisted of 50 women aged 18 and over who underwent P.D.S. from 2018 to 2020 with P.A. results of advanced stage (III-IV) epithelial-type ovarian cancer. CA-125 and albumin levels were assessed before surgery and compared with the findings of P.D.S., which were grouped into suboptimal debulking and optimal debulking. There were no significant differences in the characteristics of the two groups. The accuracy of CA-125 levels on the outcome of P.D.S. surgery with a sensitivity of 75.6%, specificity of 55.6%, PPV of 88.6%, N.P.V. of 35.3% and accuracy of 72%. While the accuracy of albumin levels on the outcome of P.D.S. surgery with a sensitivity of 55.6%, specificity of 51.2%, PPV of 20%, N.P.V. of 84% and accuracy of 52%. CA-125 levels were higher in the suboptimal group but not statistically significant, but the sensitivity (70%) and specificity (80%) were still high, so they still have diagnostic value for ovarian cancer. The relationship between albumin levels and ovarian cancer is multifactorial, so it cannot be used to predict surgical outcomes
卵巢癌是一种在卵巢中生长和发展的恶性肿瘤,死亡率很高。原发性减体积手术(pds)是一种诊断和治疗方法,已成为标准选择。CA-125水平随着卵巢癌病情的恶化而升高。此外,术前白蛋白水平与卵巢癌预后不良密切相关。本研究评估了CA-125标志物和白蛋白水平对pds预后的预测。这项研究是在I.G.N.G. Ngoerah教授医院进行的一项诊断试验。研究样本包括50名18岁及以上的女性,她们在2018年至2020年期间接受了pds, P.A.结果为晚期(III-IV)上皮型卵巢癌。术前评估CA-125和白蛋白水平,并与pds的结果进行比较,将其分为次理想减容和最佳减容。两组患者的特征无明显差异。CA-125水平对pds手术预后的准确性敏感性为75.6%,特异性为55.6%,PPV为88.6%,n.p.v为35.3%,准确性为72%。而白蛋白水平对pds手术预后的准确性敏感性为55.6%,特异性为51.2%,PPV为20%,n.p.v为84%,准确性为52%。亚优组CA-125水平较高,但无统计学意义,但敏感性(70%)和特异性(80%)仍较高,对卵巢癌仍有诊断价值。白蛋白水平与卵巢癌之间的关系是多因素的,因此它不能用于预测手术结果
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