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Impact of Single Blast Exposure on Neuronal Damage and Protein Levels in the Rat Brain at Varying Pressures 不同压力下单次爆炸对大鼠大脑神经元损伤和蛋白质水平的影响
IF 0.2 Q4 NEUROSCIENCES Pub Date : 2024-07-16 DOI: 10.1055/s-0044-1788539
Puru Bansal, Dhananjaya I. Bhat, Chirag Jain, Sarada Subramaniam, Anita Mahadevan, Dhaval P. Shukla, B. I. Devi
Introduction Brain injuries from blasts are increasingly common in both civilian and war settings. The impact of blast injuries at different pressure levels remains unclear, and their long-term effects are not well understood. This study investigates how varying blast pressures affect the rat brain over time. Materials and Methods Forty adult Sprague-Dawley rats were randomized into four groups of 10. Three groups were exposed to blasts, while one served as a control and was only subjected to blast sounds. Each group received a single blast at different pressures, followed by neuropsychological tests. After 28 and 84 days, the rats were sacrificed to measure tau protein and acetylcholine esterase levels and to conduct histological examinations of brain tissues. Results A single blast exposure did not significantly impact visuospatial memory or recall. Despite the lack of noticeable cognitive deficits, histopathological and biochemical analyses revealed reduced tau protein levels, indicating ongoing neuronal damage. Conclusion While a single blast did not significantly impair visuospatial memory or recall in this rat model, there were decreases in tau protein and acetylcholine esterase levels, along with histological signs of neuronal damage.
导言 爆炸造成的脑损伤在平民和战争环境中都越来越常见。不同压力水平的爆炸伤害所造成的影响尚不清楚,其长期影响也不甚了解。本研究探讨了不同爆炸压力对大鼠大脑的长期影响。材料和方法 将 40 只成年 Sprague-Dawley 大鼠随机分为四组,每组 10 只。三组暴露于爆炸声,一组作为对照组,只接受爆炸声。每组接受一次不同压力的爆炸,然后进行神经心理测试。28 天和 84 天后,将大鼠处死,测量 tau 蛋白和乙酰胆碱酯酶水平,并对脑组织进行组织学检查。结果 一次爆炸暴露对视觉空间记忆或回忆没有明显影响。尽管没有明显的认知障碍,但组织病理学和生化分析显示 tau 蛋白水平降低,表明神经元正在受到损伤。结论 在这种大鼠模型中,虽然一次爆炸没有明显损害视觉空间记忆或回忆能力,但 tau 蛋白和乙酰胆碱酯酶水平有所降低,组织病理学上也有神经元损伤的迹象。
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引用次数: 0
Neurotrauma and Cerebrospinal Fluid in Homer's Poems 荷马史诗中的神经创伤与脑脊液
IF 0.2 Q4 NEUROSCIENCES Pub Date : 2024-07-16 DOI: 10.1055/s-0044-1788628
Carlos Enrique Hernández Borroto, Orquidia Reyes de Hernández, Y. M. Plana
Homer's Iliad, from the 8th century BC, remains the oldest record of Greek medicine and a unique source of surgical history. The Odyssey, also authored by Homer, narrates several medically significant events. Among the 148 war traumas described in the Iliad, over a quarter occurred in the craniocervical region. Studies on the Odyssey report at least 11 craniocervical traumas, 9 of which prove fatal. Is there any indication of the presence of cerebrospinal fluid (CSF) in the cases described by Homer, considering its last mention was 800 years prior in the Egyptian surgical papyrus of Edwin Smith? A passage in the Iliad suggests that the “tears” Homer mentions in the eyes of Eumelos, resulting from trauma, might be due to CSF oculorrhea secondary to a skull base fracture. In Odyssey Book IX, when the Cyclops strikes the heads of two sailors, and fluid and cranial contents emerge, it can be inferred that the poet was aware of fluid in the head (CSF), as there is no mention of blood. It is proposed that 800 years after the writing of the Edwin Smith papyrus, Homer probably provides the second human observation of CSF associated with traumatic situations involving direct head blows.
公元前 8 世纪荷马的《伊利亚特》是希腊医学史上最古老的记录,也是外科史上独一无二的资料来源。同样由荷马撰写的《奥德赛》叙述了几件在医学上意义重大的事件。在《伊利亚特》描述的 148 处战争创伤中,超过四分之一发生在颅颈部。关于《奥德赛》的研究报告称,至少有 11 处颅颈部创伤,其中 9 处被证明是致命的。荷马所描述的病例中是否存在脑脊液(CSF)的迹象,因为最后一次提到脑脊液是在 800 年前埃德温-史密斯的埃及外科纸莎草纸上?伊利亚特》中的一段话表明,荷马提到的欧米洛斯因外伤导致的眼睛 "流泪",可能是由于颅底骨折继发的脑脊液性眼炎。在《奥德赛》第九卷中,当独眼巨人击打两名水手的头部时,液体和颅内容物流出,可以推断诗人意识到头部有液体(CSF),因为没有提到血液。有人认为,在埃德温-史密斯纸莎草纸成书 800 年后,荷马很可能是人类第二次观察到与头部直接受到撞击的创伤情况有关的脑脊液。
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引用次数: 0
An Unusual Case of Teeth in Neck: An Interesting Case Report 颈部长牙的罕见病例:有趣的病例报告
IF 0.2 Q4 NEUROSCIENCES Pub Date : 2024-07-10 DOI: 10.1055/s-0044-1788538
V. Wadhwa, Swati Tandon, Maya Singh, Daamini Bapat
Background Foreign bodies of neck are a common occurrence after trauma and road traffic accidents. Foreign bodies can get lodged in the neck especially after open wound. These could range from a piece of glass, wood, pebble pieces, or the part of tool used for trauma. Case Presentation We report a case of an unusual foreign body in the neck. Posttrauma, patient had mandibular fracture with dislodgement of teeth in the neck masquerading as foreign body. Patient required surgical intervention for removal of teeth from the neck via an external incision and recovered uneventfully. Conclusion The aim of the article was to highlight the importance of complete clinical and radiological examination in a patient of trauma. Missing teeth especially in cases of mandibular fracture must be searched for carefully.
背景 颈部异物是外伤和道路交通事故后的常见病。异物可能卡在颈部,尤其是开放性伤口后。这些异物可能是玻璃片、木头、鹅卵石碎片,也可能是用于创伤的工具部件。病例介绍 我们报告了一例颈部异常异物的病例。患者在外伤后出现下颌骨骨折,颈部牙齿脱落并被异物掩盖。患者需要进行手术治疗,通过外部切口将牙齿从颈部取出,术后恢复顺利。结论 本文旨在强调对外伤患者进行全面临床和放射检查的重要性。尤其是在下颌骨骨折的情况下,必须仔细寻找缺失的牙齿。
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引用次数: 0
Cognitive Outcomes following Virtual Reality Rehabilitation in Patient with Traumatic Brain Injury: A Prospective Randomized Comparative Study 脑外伤患者接受虚拟现实康复治疗后的认知结果:前瞻性随机比较研究
IF 0.2 Q4 NEUROSCIENCES Pub Date : 2024-07-04 DOI: 10.1055/s-0044-1778735
Ankit Sharma, Arvind Sharma, Surendra Jain, Ashok Gupta, Virendra Deo Sinha
Abstract Introduction  Comprehensive rehabilitation is essential to enhance the quality of life and cognitive performance of traumatic brain injury (TBI) survivors. Virtual reality (VR) has emerged as a promising tool for TBI rehabilitation due to its ability to provide an engaging and tailored environment. Materials and Methods  This was a randomized comparative study conducted at tertiary hospital and included individuals aged between 18 and 60 with mild-to-moderate cognitive impairment due to TBI. The participants were divided into a case group receiving intensive VR rehabilitation and a control group receiving standard care. Cognitive assessments were conducted before and after treatment, and during follow-up. Results  VR rehabilitation demonstrated significant improvements in cognitive function. The VR group exhibited remarkable progress in the Montreal Cognitive Assessment (MoCA), Tower of London (TOL), and Trail Making Test (TMT) scores. Baseline MoCA, TOL, and TMT scores (mean value) of case group 16.5, 11.75, and 14.05 and for control group 17, 10, and 13 were respectively. All the parameters of case group improved at the time of discharge (MoCA: 24.3, TOL: 22, TMT: 27.5) and in follow-up (MoCA: 28.5, TOL: 32.5, TMT: 42.07) as compared with control group at discharge (MoCA: 19, TOL: 13, TMT: 17) and in follow-up (MoCA: 21, TOL: 15, TMT: 19), which shows significant improvement in case group ( p  < 0.001) as compared with control group. Conclusion  VR rehabilitation significantly improves cognitive outcomes in TBI patients. It has the potential to be a significant tool in TBI rehabilitation.
摘要 引言 综合康复对于提高创伤性脑损伤(TBI)幸存者的生活质量和认知能力至关重要。虚拟现实(VR)因其能够提供引人入胜和量身定制的环境,已成为创伤性脑损伤康复的一种有前途的工具。材料和方法 这是一项在三级医院进行的随机比较研究,研究对象包括年龄在 18 岁至 60 岁之间、因创伤性脑损伤而患有轻度至中度认知障碍的人。参与者被分为接受强化虚拟现实康复的病例组和接受标准护理的对照组。在治疗前后和随访期间进行认知评估。结果 VR 康复治疗明显改善了认知功能。VR 组在蒙特利尔认知评估 (MoCA)、伦敦塔 (TOL) 和寻迹测试 (TMT) 分数方面取得了显著进步。病例组的基准 MoCA、TOL 和 TMT 分数(平均值)分别为 16.5、11.75 和 14.05,对照组分别为 17、10 和 13。与对照组出院时(MoCA:19,TOL:13,TMT:17)和随访时(MoCA:21,TOL:15,TMT:19)相比,病例组出院时(MoCA:24.3,TOL:22,TMT:27.5)和随访时(MoCA:28.5,TOL:32.5,TMT:42.07)的所有参数均有所改善,这表明病例组与对照组相比有显著改善(P < 0.001)。结论 VR 康复能明显改善创伤性脑损伤患者的认知能力。它有可能成为创伤性脑损伤康复的重要工具。
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引用次数: 0
Techniques and Surgical Nuances of Management of Comminuted Fronto-Orbital Depressed Fractures: A Single-Surgeon Experience 处理粉碎性眶前凹陷骨折的技术和手术细微差别:单个外科医生的经验
IF 0.2 Q4 NEUROSCIENCES Pub Date : 2024-07-02 DOI: 10.1055/s-0044-1778729
Rahul Gupta, B. I. Devi, Subhas K Konar, Abhinith Shashidhar, Dhaval Shukla
Abstract Compound fronto-orbital depressed fractures (FODFs) are complex fractures involving the frontal and orbital bones, with associated lacerated wounds on the skin. Repairing such fractures is challenging and requires a multidisciplinary approach. Surgical indications include cerebrospinal fluid rhinorrhea, exposed brain matter, frontal sinus fractures, vision impairment, and cosmetic disfigurement. The repair is typically done using titanium implants (low-profile plates [LPPs] and screws) for a good functional outcome. In this case series of 10 patients operated by a single surgeon (RG), we present different techniques for repairing FODF. Early surgery (< 48 hours) was performed to minimize infection risk. Surgical steps included elevation of depressed fragments, dural repair, and reconstruction of orbital walls using LPP. Some cases required inside-out fixation or suture fixation for better alignment of fragments. Autograft was used for severe bone loss. The results showed good functional outcomes with minimal infection rates. Primary single-stage repair using titanium implants provided satisfactory cosmesis. The use of inside-out repair and sutures was beneficial in specific cases. In conclusion, primary repair of FODF with titanium implants is safe and effective, reducing morbidity and cost. Early surgery and proper techniques are crucial for successful outcomes. Longer follow-up is needed to assess long-term viability and bone resorption.
摘要 复合性额眶凹陷骨折(FODF)是涉及额骨和眶骨的复杂骨折,伴有皮肤撕裂伤。修复此类骨折极具挑战性,需要采用多学科方法。手术适应症包括脑脊液鼻出血、脑物质外露、额窦骨折、视力障碍和外观毁损。为了获得良好的功能效果,通常使用钛植入物(低位钢板 [LPPs] 和螺钉)进行修复。在这组由一名外科医生(RG)手术的 10 例患者的病例中,我们介绍了修复 FODF 的不同技术。为了将感染风险降至最低,我们在早期(< 48 小时)进行了手术。手术步骤包括抬高凹陷碎片、硬脑膜修复和使用 LPP 重建眶壁。有些病例需要进行内固定或缝合固定,以更好地对齐碎片。骨质流失严重的病例采用自体移植。结果显示,手术效果良好,感染率极低。使用钛种植体进行初级单阶段修复的效果令人满意。在特殊病例中,使用内向外修复和缝合也有好处。总之,使用钛植入物对 FODF 进行初级修复是安全有效的,可以降低发病率和费用。早期手术和正确的技术是取得成功的关键。需要进行更长时间的随访,以评估长期存活率和骨吸收情况。
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引用次数: 0
Assessment of the Efficacy of an Automated AMBU Bag Operating Device (RC Device) in Patients Requiring Mechanical Ventilation: A Pilot Study 评估自动 AMBU 袋操作装置(RC 装置)对需要机械通气患者的疗效:试点研究
IF 0.2 Pub Date : 2024-06-14 DOI: 10.1055/s-0043-1777675
R. Chauhan, S. Bloria, Priya Thappa, Raman Sharma, R. Sarna, Shyam C. Meena, A. Luthra, Nidhi B. Panda, Sandeep Mohindra, Nidhi Singh, Swati Patel
Abstract Background  Providing efficient mechanical ventilation using artificial manual breathing unit is a tiring and laborious task for healthcare providers. The current pilot study was planned to assess the efficacy of an automated artificial mechanical breathing unit (respiration control [RC] device) in patients requiring mechanical ventilation in a tertiary care hospital in North India. RC device is an automated bag valve mask ventilator developed in collaboration with Gyrodrive Machineries (P) Ltd. India and Postgraduate Institute of Medical Education and Research, Chandigarh. Methods  Ten adult patients from the emergency and trauma section requiring mechanical ventilation who were unable to obtain ventilators in the intensive care unit were enrolled in the study. The vital parameters of the patients and the respiratory parameters from arterial blood gas were recorded at given time periods. Results  All 10 patients recruited in the study were ventilated using the RC device for at least 24 hours. The mean age of the patients was 32.3 ± 4.3 years. The mean Glasgow coma scale was 7.2 ± 2.0 (range: 3–10). The heart rate, systolic blood pressure, and diastolic blood pressure remained within normal limits. There were no episodes of desaturation in any of the patients. The patients' care provider rated their satisfaction with the device as excellent in two patients and good in eight patients. Conclusion  RC device has shown a promising result in providing satisfactory care among trauma patients and may be used in providing routine mechanical ventilation among these patients.
摘要 背景 使用人工手动呼吸装置提供高效的机械通气对医护人员来说是一项既劳累又费力的工作。目前的试点研究旨在评估自动化人工机械呼吸装置(呼吸控制 [RC] 装置)对北印度一家三级医院中需要机械通气的患者的疗效。RC 设备是与印度 Gyrodrive Machineries (P) Ltd. 和印度医学研究生院合作开发的自动袋阀面罩呼吸机。印度和昌迪加尔医学教育与研究研究生院合作开发。研究方法 研究对象为急诊和创伤科需要机械通气且无法在重症监护室获得呼吸机的 10 名成年患者。在特定时间段记录患者的生命参数和动脉血气的呼吸参数。结果 研究中招募的所有 10 名患者均使用 RC 设备通气至少 24 小时。患者的平均年龄为(32.3 ± 4.3)岁。格拉斯哥昏迷量表的平均值为 7.2 ± 2.0(范围:3-10)。心率、收缩压和舒张压均保持在正常范围内。所有患者均未出现饱和度降低的情况。2 名患者的护理人员对该装置的满意度为 "优",8 名患者的满意度为 "良"。结论 RC 设备在为创伤患者提供令人满意的护理方面显示出良好的效果,可用于为这些患者提供常规机械通气。
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引用次数: 0
Demographic Profile, Clinical Features, Imaging, and Outcomes in Patients with Traumatic Brain Injury Presenting in Garhwal Himalayas in Tertiary Care Hospital 在喜马拉雅山脉加尔瓦尔地区三级医院就诊的脑外伤患者的人口统计学特征、临床特征、影像学检查和治疗结果
IF 0.2 Pub Date : 2024-06-10 DOI: 10.1055/s-0044-1787699
Ritish Garg, Pankaj Arora, Vibhu Shankar
Abstract Introduction  Traumatic brain injury (TBI) poses a significant global health challenge, accounting for over 50% of trauma-related deaths and emerging as a leading cause of mortality and disability. Objective  This article studies the demographic characteristics, clinical features, imaging findings, and outcomes of TBI patients. Materials and Methods  This was a retrospective observational study conducted on 490 patients with TBI. Data regarding age, gender, socioeconomic status, and residential location were extracted from medical records. Neuroimaging reports, including computed tomography (CT) scans results, were analyzed for structural and functional insights. Results  The majority of TBI cases involved individuals aged 21 to 40, with a higher incidence in males. Road traffic accidents were identified as the most common mode of injury, followed by falls. Most of the patients had moderate Glasgow Coma Scale scores at admission. CT scans indicated skull fractures, cerebral edema, and subdural hematomas as common findings. Most patients did not require ventilator support, and the majority had a hospital stay of less than 10 days. At discharge, 89.8% exhibited favorable outcomes, while 4.3% experienced mortality during treatment. Follow-up data demonstrated an overall mortality rate of 8.8%, with 89.2% achieving complete recovery within a month. Conclusion  The study underscores the importance of understanding the multifaceted aspects of TBI, emphasizing the need for integrated approaches in tertiary medical care to optimize patient outcomes and contribute to effective public health strategies.
摘要 引言 创伤性脑损伤(TBI)对全球健康构成重大挑战,占创伤相关死亡人数的 50%以上,并已成为导致死亡和残疾的主要原因。本文研究创伤性脑损伤患者的人口统计学特征、临床特征、影像学检查结果和预后。材料与方法 这是一项回顾性观察研究,研究对象为 490 名创伤性脑损伤患者。从医疗记录中提取了有关年龄、性别、社会经济地位和居住地的数据。对包括计算机断层扫描(CT)结果在内的神经影像学报告进行了分析,以了解其结构和功能。结果 大多数创伤性脑损伤病例的年龄在 21-40 岁之间,男性发病率较高。道路交通事故是最常见的受伤方式,其次是跌倒。大多数患者入院时格拉斯哥昏迷量表评分为中度。CT 扫描显示,颅骨骨折、脑水肿和硬膜下血肿是常见的检查结果。大多数患者无需呼吸机支持,住院时间少于 10 天。出院时,89.8%的患者疗效良好,4.3%的患者在治疗期间死亡。随访数据显示,总死亡率为 8.8%,89.2% 的患者在一个月内完全康复。结论 该研究强调了了解创伤性脑损伤多方面问题的重要性,强调了在三级医疗护理中采用综合方法的必要性,以优化患者的治疗效果并促进有效的公共卫生战略。
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引用次数: 0
Sports-Related Cervical Spine Injury: A Series of Two Cases with Literature Review 运动导致的颈椎损伤:两例系列病例及文献综述
IF 0.2 Pub Date : 2024-06-10 DOI: 10.1055/s-0044-1782613
Nitish Ranjan, V. Maurya, K. Bhaisora, Arun Kumar Srivastava
Abstract Sports-related cervical injuries pose a significant concern in the realm of sports medicine, affecting athletes across various disciplines and levels of competition. Cervical injuries in sports primarily result from a combination of high-impact forces, sudden acceleration–deceleration movements, and improper techniques. Common cervical injuries include sprains, strains, fractures, and more severe conditions such as cervical spine dislocations. The mechanisms underlying sports-related cervical injuries involve complex interactions between biomechanical forces, player dynamics, and environmental factors. Understanding the biomechanics of these injuries is crucial for developing effective preventive strategies. This study highlights the mechanism of injury, primary intervention including transport of athletes, and medical and surgical management with the help of two such cases managed in a single institute in this year, 2023. By addressing the multifaceted aspects of these injuries, the sports community can strive toward creating a safer environment for athletes and minimizing the impact of cervical injuries on their overall well-being and athletic performance.
摘要 与运动相关的颈椎损伤是运动医学领域的一个重大问题,影响着各学科和各级别的运动员。运动中的颈椎损伤主要是由高冲击力、突然的加速-减速运动和不正确的技术共同造成的。常见的颈椎损伤包括扭伤、拉伤、骨折以及颈椎脱位等更严重的情况。与运动相关的颈椎损伤的发生机制涉及生物力学力、运动员动态和环境因素之间复杂的相互作用。了解这些损伤的生物力学对制定有效的预防策略至关重要。本研究通过 2023 年一家研究所处理的两个此类病例,重点介绍了损伤机制、包括运动员转运在内的初级干预措施以及内外科治疗方法。通过解决这些损伤的多方面问题,体育界可以努力为运动员创造更安全的环境,最大限度地减少颈椎损伤对运动员整体健康和运动表现的影响。
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引用次数: 0
Unilateral Vision Loss after Posterior Fixation for Traumatic Atlantoaxial Dislocation: A Case Report with Literature Review 外伤性寰枢椎脱位后路固定术后单侧视力丧失:病例报告与文献综述
IF 0.2 Pub Date : 2024-06-07 DOI: 10.1055/s-0044-1782610
Guramritpal Singh, V. Maurya, K. Bhaisora, A. Srivastava, S. Behari, Raj Kumar
Abstract Postoperative vision loss following spine surgery is a rare and devastating complication with variable incidence. Various risk factors have been identified in the literature. A 16-year-old male presented with neck pain, spastic quadriparesis, and tingling paraesthesia in the left upper limb for the past 3 years. Radiological workup was suggestive of atlantoaxial dislocation with occipitalization of the posterior arch of the atlas (C1). The patient was prone to a horseshoe headrest and underwent occipito-C2-C3 fixation by removing the posterior rim of foramen magnum. Postoperatively, the patient complained of loss of vision in the right eye. Ophthalmology evaluation revealed a loss of perception of light in the right eye due to central retinal artery occlusion. An injectable steroid was started, but there was no improvement in vision in the involved eye. Proper head positioning and avoidance of intraoperative hypotension are modifiable factors to avoid such devastating complications.
摘要 脊柱手术后视力丧失是一种罕见的破坏性并发症,发生率不一。文献中发现了各种风险因素。一名 16 岁的男性患者在过去 3 年中出现颈部疼痛、痉挛性四肢瘫痪和左上肢刺痛性麻痹。放射检查提示寰枢椎脱位,寰椎后弓(C1)枕化。患者俯卧于马蹄形头枕上,并通过切除枕骨大孔后缘接受了枕骨-C2-C3固定术。术后,患者主诉右眼视力下降。眼科评估显示,右眼因视网膜中央动脉闭塞而失去光感。开始注射类固醇,但受影响眼睛的视力没有改善。正确的头部定位和避免术中低血压是避免此类破坏性并发症的可控因素。
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引用次数: 0
The Lucid Interval of Tsarevich Ivan Ivanovich Could Have Been Due to an Epidural Hematoma 伊万-伊万诺维奇的清醒间歇可能是硬膜外血肿所致
IF 0.2 Pub Date : 2024-06-07 DOI: 10.1055/s-0044-1787698
Carlos Enrique Hernández Borroto, Orquidia Reyes de Hernández
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引用次数: 0
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Indian Journal of Neurotrauma
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