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New Approach to Policy Effectiveness for Covid-19 and Factors Influence Policy Effectiveness 应对新冠肺炎政策有效性新思路及影响政策有效性的因素
Yile He
This study compared the effectiveness of COVID-19 control policies, including wearing masks, and the vaccine rates through proportional infection rate in 28 states of the United States using the eSIR model. The effective rate of policies was measured by the difference between the predicted daily infection proportion rate using the data before the policy and the actual daily infection proportion rate. The study suggests that both mask and vaccine policy had a significant impact on mitigating the pandemic. We further explored how different social factors influenced the effectiveness of a specific policy through the linear regression model. Out of 9 factors, the population density, number of hospital beds per 1000 people, and percent of the population over 65 are the most substantial factors on mask policy effectiveness, while public health funding per person, percent of immigration have the most significant influence on vaccine policy effectiveness. This study summarized the effectiveness of different policies and factors they associated with. It can be served as a reference for future covid-19 related policy.
本研究采用eSIR模型,通过比例感染率比较了美国28个州戴口罩等新冠肺炎防控政策的有效性和疫苗接种率。以政策实施前数据预测的每日感染比例与实际每日感染比例之差来衡量政策的有效性。这项研究表明,口罩和疫苗政策都对缓解大流行产生了重大影响。我们通过线性回归模型进一步探讨了不同社会因素对特定政策有效性的影响。在9个因素中,人口密度、每1000人的医院床位数和65岁以上人口的百分比是影响口罩政策有效性的最重要因素,而人均公共卫生资金、移民百分比对疫苗政策有效性的影响最为显著。本研究总结了不同政策的有效性及其相关因素。为今后制定新冠肺炎相关政策提供参考。
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引用次数: 1
The impact of CoViD-19 on the hospital activities: the case of the Neurosurgery Department of “San Giovanni di Dio e Ruggi d'Aragona” University Hospital 新冠肺炎疫情对医院活动的影响——以“圣乔凡尼·迪奥·鲁吉·阿拉戈纳”大学医院神经外科为例
A. Scala, Teresa Angela Trunfio, I. Loperto, R. Alfano, A. Lombardi, A. Borrelli, M. Triassi, G. Improta
Background. The CoViD-19 pandemic has hit the public health system in many nations hard. The long incubation period, the high infectious rate, the varied manifestation and the lack of effective treatment make managing the transmission of the disease difficult. For this reason, the health focus has been shifted to its management, thus limiting the activity carried out by surgical specialties. In neurosurgery, the complexity and importance of treatments in some cases requires timely intervention that cannot be delayed. Methods. In this study, the demographic and activity data of patients discharged from the Complex Operative Units (COU) of Neurosurgery and Neurosurgical Clinic of the "San Giovanni di Dio e Ruggi d'Aragona" University Hospital of Salerno (Italy) in the years 2019 (pre-pandemic) and 2020 (during the pandemic) were analyzed using statistical test and logistic regression. Results. Both statistical tests and logistic regression showed a significant increase in the weight of the Diagnosis Related Group (DRG) obtained from the COUs, demonstrating an improvement in the appropriateness of the services provided. Conclusion. This work demonstrates how a more consistent use of the hospital due to fear and containment measures has improved the performance of the COU.
背景。新冠肺炎大流行严重打击了许多国家的公共卫生系统。该病潜伏期长,传染性高,表现形式多样,缺乏有效的治疗手段,给控制该病的传播带来了困难。因此,卫生重点已转移到其管理上,从而限制了外科专科开展的活动。在神经外科中,治疗的复杂性和重要性在某些情况下需要及时干预,不能拖延。方法。本研究对意大利萨莱诺大学医院“圣乔瓦尼·迪·迪·鲁吉·达·阿拉戈纳”神经外科和神经外科综合手术单元(COU) 2019年(大流行前)和2020年(大流行期间)出院患者的人口统计学和活动数据进行了统计检验和logistic回归分析。结果。统计检验和逻辑回归都表明,从诊断相关组获得的诊断相关组(DRG)的权重显著增加,表明所提供服务的适当性有所改善。结论。这项工作表明,由于恐惧和遏制措施而更加一致地使用医院如何提高了COU的绩效。
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引用次数: 3
Type II Diabetes as the Main Risk Factor of Arterial Stiffness in Chronic Kidney Disease Patients II型糖尿病是慢性肾病患者动脉硬化的主要危险因素
H. Susilo, M. Y. Alsagaff, B. Pikir, M. Thaha, C. Wungu
Chronic kidney disease (CKD) is frequently linked to an increased risk of cardiovascular disease. Diabetes, hypertension, dyslipidemia, and obesity are all traditional risk factors of cardiovascular disease in CKD. However, the contribution of each of the traditional risk factors to arterial stiffness is unknown. This was a correlational study with a cross-sectional design. This study included forty CKD patients from Universitas Airlangga Hospital Surabaya, between December 2019 until March 2020. Serum samples were used to measure laboratory parameters, and Doppler ultrasound was used to assess carotid-femoral Pulse Wave Velocity (cfPWV). Spearman's analysis was conducted to determine correlations between cf-PWV and e-GFR, HBA1C, serum creatinine, and cystatin-C. Mann-Whitney test was performed to determine the association between type II diabetes with cf-PWV. Significant results were continued with linear regression analysis model. There were significant correlations between cf-PWV and e-GFR, HBA1C, serum creatinine, and cystatin-C. HBA1C showed the most significant positive correlation with a moderate correlation coefficient (p = 0.000; r = 0.581). Patients with type II diabetes was associated with increased cf-PWV. Linear regression model also revealed that HBA1C and history of diabetes were significant predictors of increased cf-PWV in CKD patients (β= 0.400; p = 0.011 and β= 0.537; p = 0.000, respectively). We found a positive correlation between HBA1C and cf-PWV and association between type II diabetes and increased cf-PWV. This proved that type II diabetes, especially with high HBA1C, acted as a significant risk factor for predicting increased arterial stiffness in CKD patients.
慢性肾脏疾病(CKD)通常与心血管疾病的风险增加有关。糖尿病、高血压、血脂异常和肥胖都是CKD中心血管疾病的传统危险因素。然而,每个传统的危险因素对动脉硬化的贡献是未知的。这是一项横断面设计的相关研究。该研究包括2019年12月至2020年3月期间泗水艾尔朗加大学医院的40名CKD患者。血清样本测量实验室参数,多普勒超声评估颈-股脉波速度(cfPWV)。进行Spearman分析以确定cf-PWV与e-GFR、HBA1C、血清肌酐和胱他汀- c之间的相关性。采用Mann-Whitney检验确定2型糖尿病与cf-PWV之间的关系。采用线性回归分析模型继续分析显著性结果。cf-PWV与e-GFR、HBA1C、血清肌酐和胱抑素c有显著相关性。HBA1C呈最显著正相关,相关系数为中等(p = 0.000;R = 0.581)。2型糖尿病患者与cf-PWV升高相关。线性回归模型还显示,HBA1C和糖尿病史是CKD患者cf-PWV升高的显著预测因子(β= 0.400;P = 0.011, β= 0.537;P = 0.000)。我们发现HBA1C与cf-PWV呈正相关,II型糖尿病与cf-PWV升高相关。这证明,II型糖尿病,特别是高HBA1C,是预测CKD患者动脉僵硬度增加的重要危险因素。
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引用次数: 0
A multiple regression model for modelling the hospital patients LOS’ of laparoscopic cholecystectomy: a bicentric study 腹腔镜胆囊切除术患者LOS的多元回归模型:一项双中心研究
Ida Santalucia, Marta Rosaria Marino, E. Raiola, Massimo Majolo, Giuseooe Russo, G. Longo, Giuseppe Ferrucci, A. Borrelli, M. Triassi
Laparoscopic cholecystectomy (LC) interventions have had a great impact on health management and the effect has been evident in reducing the length of stay (LOS). This parameter is usually used as a performance indicator in order to measure the goodness of a health process. The prediction and control of this indicator is of considerable relevance for the management of hospital practice. In the following work the aim is to predict LOS for patients having LC surgery, using a linear model, at the University Hospital “San Giovanni di Dio and Ruggi d'Aragona” of Salerno (Italy) and at the A.O.R.N. "Antonio Cardarelli". Data were collected over two different years in order to compare the benefits of implementing some corrective actions introduced during the extracted time interval to increase the performance of the process under consideration. Linear regression models were implemented for each year and for each hospital. Obtained results show that in both hospitals a good predictive power of the models (R2= 0.84 and R2 = 0.97 and R2= 0.96 and R2 = 0.97 respectively).
腹腔镜胆囊切除术(LC)干预措施对健康管理产生了很大的影响,并且在减少住院时间(LOS)方面效果明显。此参数通常用作性能指标,以衡量运行状况进程的良好性。该指标的预测和控制对医院实践管理具有重要意义。在接下来的工作中,目的是使用线性模型预测在萨勒诺(意大利)的“圣乔瓦尼迪迪奥和鲁吉阿拉戈纳”大学医院和A.O.R.N.进行LC手术的患者的LOS“安东尼奥Cardarelli”。数据是在两个不同的年份收集的,以便比较在提取的时间间隔内实施一些纠正措施的好处,以提高所考虑的过程的性能。对每年和每家医院实施线性回归模型。结果表明,两家医院模型的预测能力均较好(R2= 0.84、R2= 0.97、R2= 0.96、R2= 0.97)。
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引用次数: 0
Digital Public Health Surveillance with Online Health Consultation Data: An Example of HIV Monitoring 基于在线健康咨询数据的数字公共卫生监测:艾滋病毒监测的一个例子
Chen Liu, William Yu Chung Wang, Gohar Khan
There is increasing interest in obtaining electronic information from sources other than official public health organizations for public health surveillance. The potential of novel digital data sources, such as internet news, search engine, social media, mobile apps and wearable devices in improving the speed, scope and temporal precision of disease surveillance have been demonstrated. However, the value of Online Health Consultation (OHC) data in public health surveillance is ignored. This study aims to assess the predictive value of OHC data in public health surveillance. This study constructs a public health surveillance system for HIV with OHC data based on the medical entities extraction and disease prediction two-module framework. This research outcome will contribute to closing the knowledge gap in the research area of digital public health surveillance and provide inspiration for relevant scholars to make better use of OHC data in their research.
人们越来越有兴趣从官方公共卫生组织以外的来源获取电子信息,用于公共卫生监测。新型数字数据源,如互联网新闻、搜索引擎、社交媒体、移动应用程序和可穿戴设备,在提高疾病监测的速度、范围和时间精度方面的潜力已经得到证明。然而,在线健康咨询(OHC)数据在公共卫生监测中的价值被忽视。本研究旨在评估OHC数据在公共卫生监测中的预测价值。本研究基于医疗实体提取和疾病预测两模块框架,构建基于OHC数据的HIV公共卫生监测系统。这一研究成果将有助于缩小数字公共卫生监测研究领域的知识差距,并为相关学者在研究中更好地利用OHC数据提供启发。
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引用次数: 0
Characteristics of the information needs of hypertension patients on online healthcare service platforms 高血压患者在线医疗服务平台信息需求特征
Tingting Zhang, Sunjing Zheng, Yundi Zhang
Hypertension has become the most risk factor for cardiovascular and cerebrovascular diseases. The purpose of this study is to reveal the information needs and evolution of hypertensive patients on online healthcare service platforms. We use the methods of statistical analysis, word frequency analysis and social network analysis to explore the information needs of hypertensive patients. The study found that the middle-aged and elderly people have the most information needs about hypertension on the online healthcare service platform, while the patients with physical examination and exercise needs are more inclined to be younger, and young male hypertension patients have more information needs than female patients. The findings recommend that middle-aged and elderly people should have regular physical examinations and exercise, and a comprehensive face-to-face system should be established on online healthcare service platforms to improve the utilization of existing question-and-answer data.
高血压已成为心脑血管疾病的最危险因素。本研究旨在揭示高血压患者在网络医疗服务平台上的信息需求及其演变。运用统计分析、词频分析、社会网络分析等方法,探讨高血压患者的信息需求。研究发现,在网络健康服务平台上,中老年人对高血压的信息需求最多,而有体检和运动需求的患者更倾向于年轻化,年轻男性高血压患者的信息需求多于女性患者。研究结果建议中老年人应定期进行身体检查和锻炼,并在在线医疗服务平台上建立全面的面对面系统,以提高现有问答数据的利用率。
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引用次数: 0
Mechanism of necrotizing enterocolitis in preterm infants through the hypoxia signaling pathway, neuronal-glial signaling pathway, and intestinal fatty acid signaling pathway 缺氧信号通路、神经元-胶质信号通路、肠脂肪酸信号通路对早产儿坏死性小肠结肠炎发病机制的影响
D. Angelika, R. Etika, I. Ugrasena
The etiology of necrotizing enterocolitis (NEC) is influenced by many factors including hypoxia, intestinal immaturity, bacterial colonization, reactive oxidants, and imbalanced inflammatory response; therefore, the pathogenesis of NEC is considered multifactorial. However, the pathogenesis of NEC has not been fully elucidated and requires further investigation. This study aimed to analyze the association between hypoxia inducible factor-1alpha (HIF-1alpha), glial fibrillary acidic protein (GFAP), glial derived neutrophic factor (GDNF), fatty acid binding protein-2 (FABP-2), peroxime proliferator activated receptor-gamma (PPAR-gamma), interleukin-6 (IL-6), and interleukin-8 (IL-8) with the incidence of NEC in preterm infants. All preterm infants with birth weight <1500 grams or gestational age <34 weeks were included in this study. After the umbilical cord was removed, 1 mL of umbilical blood was taken for HIF-1alpha, GFAP, GDNF, FABP-2, PPAR-gamma, IL-6, and IL-8 examination. Examination of HIF-1alpha, GFAP, GDNF, FABP-2, PPAR-gamma, IL-6, and IL-8 was repeated in infants with NEC symptoms using peripheral venous blood specimen. Infants were observed for 2 weeks. NEC was diagnosed based on clinical symptoms and abnormal abdominal radiographs. Of the 30 infants, there were 9 (30%) infants who experienced NEC. Logistic regression analysis showed significant results on GFAP with Odds Ratio (OR)=15.629 (95% confidence interval=1.697-143.906) P=0.015 and FABP-2 with OR=1.008 (1.001-1.015) P=0.033. Multivariate analysis using Backward LR logistic regression model showed significant results on GFAP with adjusted OR=15.629 (1.697-143.906) with P=0.015. This study demonstrated that GFAP and FABP-2 were significantly associated with the incidence of NEC. This may explain the pathogenesis of NEC through a hypoxic mechanism.
坏死性小肠结肠炎(NEC)的病因受多种因素影响,包括缺氧、肠道不成熟、细菌定植、活性氧化剂和不平衡的炎症反应;因此,NEC的发病机制被认为是多因素的。然而,NEC的发病机制尚未完全阐明,需要进一步研究。本研究旨在分析缺氧诱导因子-1 α (hif -1 α)、胶质原纤维酸性蛋白(GFAP)、胶质源性中性营养因子(GDNF)、脂肪酸结合蛋白-2 (FABP-2)、过氧化物酶增殖物激活受体- γ (ppar - γ)、白细胞介素-6 (IL-6)、白细胞介素-8 (IL-8)与早产儿NEC发病的关系。所有出生体重<1500克或胎龄<34周的早产儿均纳入本研究。取脐血1ml,检测hif -1 α、GFAP、GDNF、FABP-2、ppar - γ、IL-6、IL-8。采用外周静脉血标本对NEC症状患儿重复检测hif -1 α、GFAP、GDNF、FABP-2、ppar - γ、IL-6和IL-8。观察婴儿2周。NEC是根据临床症状和腹部异常x线片诊断的。在30例婴儿中,有9例(30%)婴儿出现NEC。Logistic回归分析结果显示,GFAP的比值比(OR)=15.629(95%可信区间为1.697 ~ 143.906)P=0.015, FABP-2的比值比(OR)= 1.008 (1.001 ~ 1.015) P=0.033。采用后向LR logistic回归模型进行多因素分析,GFAP的校正OR=15.629 (1.697-143.906), P=0.015。本研究表明GFAP和FABP-2与NEC的发病率显著相关。这可能通过缺氧机制解释NEC的发病机制。
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引用次数: 0
The comparison of non-invasive ICPsnapshot and non-invasive ICPmonitoring methods on healthy volunteer: A pilot study. 无创ICPsnapshot与无创ICPmonitoring在健康志愿者中的比较:一项初步研究。
Vilma Putnynaite, L. Bartusis, S. Krakauskaite, R. Zakelis, Y. Hamarat
Intracranial pressure (ICP) monitoring is essential in management and in treatment of neurosurgical, neurological, and in some cases of ophthalmological patients. However, ICP monitoring is not suitable for a wider range of patient groups due to the invasiveness. Non-invasive ICP estimation would also be valuable in other clinical situations where patients are conscious (nephrology, aerospace, and sport medicine, etc.). In case of ophthalmology, ICP and intraocular pressure is considered to be two key factors for precise and patient individual normal tension and high-tension glaucoma diagnosis. Here, we have compared two different non-invasive ICP measurement methods. After snapshot calibration by non-invasive ICP snapshot measurement method, the ICP monitoring method could be used in glaucoma patients in cases where ICP values are low than the normal range.
颅内压(ICP)监测在神经外科、神经内科和某些眼科患者的管理和治疗中是必不可少的。然而,由于其侵入性,ICP监测并不适用于更广泛的患者群体。非侵入性ICP估计在其他临床情况下也有价值,患者是有意识的(肾脏病学,航空航天和运动医学等)。在眼科中,ICP和眼压被认为是准确诊断正常眼压和高眼压青光眼的两个关键因素。在这里,我们比较了两种不同的非侵入性ICP测量方法。采用无创ICP快照测量法标定快照后,在青光眼患者ICP值低于正常范围时,可采用ICP监测方法。
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引用次数: 0
Lean Six Sigma approach to the study of the LOS of patients who undergo laparoscopic cholecystectomy: a bicentric study 采用精益六西格玛方法研究腹腔镜胆囊切除术患者的LOS:一项双中心研究
E. Montella, Marta Rosaria Marino, Massimo Majolo, E. Raiola, Giuseppe Russo, G. Longo, Michele Sparano, A. Borrelli, M. Triassi
Laparoscopic cholecystectomy (LC) is considered the standard procedure for the treatment of gallstone. Compared to traditional surgery with the introduction of this procedure reduces the recovery time for a patient. According to literature, the postoperative LOS after LC is generally between 3 and 5 days. Length of stay (LOS) is a crucial piece of the patient experience and has proven to be an important indicator of health care efficiency. In the work the clinical data of the patients of the University Hospital "San Giovanni di Dio e Ruggi d'Aragona" of Salerno and the patients of the A.O.R.N. "Antonio Cardarelli" of Naples (Italy) were used, comparing two years (2016-2017) to demonstrate that the introduction of corrective actions have led to a reduction in the postoperative LOS. A Lean Six Sigma approach was used, with the implementation of the DMAIC cycle (Define, Measure, Analyze, Improve, Control), thanks to which it was possible to demonstrate significant results in the reduction of post-operative hospitalizations.
腹腔镜胆囊切除术(LC)被认为是治疗胆结石的标准程序。与传统手术相比,该手术的引入缩短了患者的恢复时间。据文献报道,LC术后LOS一般在3 - 5天之间。住院时间(LOS)是患者体验的一个关键部分,已被证明是卫生保健效率的一个重要指标。在工作中,Salerno大学医院“San Giovanni di Dio e Ruggi d'Aragona”的患者和a.o.r.n的患者的临床资料使用那不勒斯(意大利)的“Antonio Cardarelli”,比较两年(2016-2017)来证明纠正措施的引入导致了术后LOS的减少。采用精益六西格玛方法,并实施DMAIC循环(定义、测量、分析、改进、控制),因此有可能在减少术后住院治疗方面取得显著成果。
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引用次数: 0
Develop a Natural Language Processing Pipeline to Automate Extraction of Periodontal Disease Information from Electronic Dental Clinical Notes 开发一种自然语言处理管道,从电子牙科临床记录中自动提取牙周病信息
J. Patel, R. Rao, R. Brandon, Vishnu Iyer, J. Albandar, M. Tellez, J. Krois, Huanmei Wu
Introduction: Periodontal disease (PD) is one of the most prevalent dental diseases, suffered by 80% of US adults. PD can be prevented if its etiologic and risk factors are identified and controlled early. Electronic dental record (EDR) data provide researchers a unique opportunity to develop prediction models that can provide personalized disease risk and treatment recommendations. However, 90% of important clinical information is documented only in the free-text format of EDR. The objective of this study was to develop natural language processing (NLP) applications to extract PD diagnoses, medical histories (e.g., cardiovascular diseases, diabetes), and social history (e.g., smoking) in a structured format for comprehensive follow-up periodontal research. Methods: We have developed a five-stage NLP pipeline. First, we retrieved both structured and non-structured data from the EDR using SQL queries. Next, we developed manual annotation guidelines using both the bottom-up and top-down approaches. The manual annotations were performed by experts in Step 3, which also built the gold standard data. Part of the gold standard data was used in a named entity recognition (NER) development (Step 4), and for additional validation (Step 5). Results: The SQL queries resulted in a cohort of 27,138 unique patients, each with multiple clinical notes. The manual annotation guidelines were based on 100 unique patients with 347 clinical notes to identify the writing patterns in our EDR system. Existing literature was also studied to develop manual annotation guidelines. For Step 3, two domain experts manually reviewed 4,000 clinical notes using the eHOST annotation tool. The evaluation showed 94.5% accuracy in extracting patients’ detailed PD diagnoses, CVD, smoking, and diabetes information from the EDR. Statistics of the extracted clinical notes improved our knowledge on periodontitis classification and other systemic diseases such as cardiovascular diseases (CVD) and diabetes. Conclusion: Our NLP pipeline increased the utilization of EDR for periodontal research from the free-text dental clinical notes. Hence, developing novel informatics methods such as NLP is critical for using EDR data optimally and efficiently for research.
牙周病(PD)是最普遍的牙齿疾病之一,80%的美国成年人患有此病。如果PD的病因和危险因素得到早期识别和控制,PD是可以预防的。电子牙科记录(EDR)数据为研究人员提供了一个独特的机会来开发预测模型,从而提供个性化的疾病风险和治疗建议。然而,90%的重要临床信息仅以电子病历的自由文本格式记录。本研究的目的是开发自然语言处理(NLP)应用程序,以结构化格式提取PD诊断,病史(如心血管疾病,糖尿病)和社会史(如吸烟),以进行全面的牙周随访研究。方法:我们开发了一个五阶段的NLP管道。首先,我们使用SQL查询从EDR检索结构化和非结构化数据。接下来,我们使用自底向上和自顶向下的方法开发了手动注释指南。手工注释由专家在步骤3中执行,该步骤也构建了金标准数据。部分金标准数据用于命名实体识别(NER)开发(步骤4)和额外验证(步骤5)。结果:SQL查询产生27,138个独特患者的队列,每个患者都有多个临床记录。手工标注指南是基于100名独特患者的347份临床笔记,以确定我们的EDR系统中的书写模式。同时研究现有文献,制定手工标注指南。对于步骤3,两位领域专家使用eHOST注释工具手动审查了4,000份临床记录。评估显示,从EDR中提取患者详细的PD诊断、CVD、吸烟和糖尿病信息的准确率为94.5%。统计提取的临床记录提高了我们对牙周炎分类和其他全身性疾病如心血管疾病(CVD)和糖尿病的认识。结论:我们的NLP管道增加了EDR在牙周研究中的利用,这些EDR来自自由文本牙科临床记录。因此,开发新的信息学方法,如NLP,对于优化和有效地利用EDR数据进行研究至关重要。
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引用次数: 1
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