Narantungalag Lkhagvasuren, Batjargal Enkh-Amgalan, Khaliun Bayar, Myagmartseren Bandi, J. Badarch
Introduction: Induction of labor is the stimulation of uterine contractions during pregnancy before labor begins on its own to achieve a vaginal birth. It is a common obstetric procedure that is indicated when the benefits to either mother or fetus outweigh those of pregnancy continuation. We aimed to determine the overall rate, outcomes, and associated factors of labor induction. Methods: A retrospective cross-sectional study was conducted among 5852 mothers delivered in "Urguu" First Maternity Hospital and National Center for Maternal and Child Health (NCMCH) between January 1st, 2019 and May 31st, 2019. SPSS version 25 was used for statistical analysis. Descriptive and binary logistic regression analyses were used to determine study variables and the association between dependent variables and independent variables. Comparison of proportions was performed by chi-square (χ2) for categorical variables to determine associations between selected covariates and induction. Results: A total of (5852) women were delivered at the research area, out of which (1079) were induced resulting in a prevalence of induction of (18.43%). Of the 1079 induced women, the most common indications for labor induction were 659 (61.1%) prolonged labor, 188 (17.4%) premature rupture of membranes, 139(12.9%) pre-eclampsia, and 87 (8.1%) oligohydramnios. Among the induced labor, 1031 (95.6%) were delivered by vaginal and 48 (4.4%) by Cesarean section. Conclusions: The prevalence of inducted labor was 18.43%. Factors associated with labor induction were maternal age, employment, residential type, and an abortion. The most common indications were premature rupture of membrane, prolonged labor, and pre-eclampsia. The successful rate was considerably higher and the frequency of cesarean sections was lower than the result of other studies.
{"title":"Prevalence, risk factors and outcomes of labor induction among women delivered at Maternity Hospitals of Mongolia","authors":"Narantungalag Lkhagvasuren, Batjargal Enkh-Amgalan, Khaliun Bayar, Myagmartseren Bandi, J. Badarch","doi":"10.1145/3545729.3545788","DOIUrl":"https://doi.org/10.1145/3545729.3545788","url":null,"abstract":"Introduction: Induction of labor is the stimulation of uterine contractions during pregnancy before labor begins on its own to achieve a vaginal birth. It is a common obstetric procedure that is indicated when the benefits to either mother or fetus outweigh those of pregnancy continuation. We aimed to determine the overall rate, outcomes, and associated factors of labor induction. Methods: A retrospective cross-sectional study was conducted among 5852 mothers delivered in \"Urguu\" First Maternity Hospital and National Center for Maternal and Child Health (NCMCH) between January 1st, 2019 and May 31st, 2019. SPSS version 25 was used for statistical analysis. Descriptive and binary logistic regression analyses were used to determine study variables and the association between dependent variables and independent variables. Comparison of proportions was performed by chi-square (χ2) for categorical variables to determine associations between selected covariates and induction. Results: A total of (5852) women were delivered at the research area, out of which (1079) were induced resulting in a prevalence of induction of (18.43%). Of the 1079 induced women, the most common indications for labor induction were 659 (61.1%) prolonged labor, 188 (17.4%) premature rupture of membranes, 139(12.9%) pre-eclampsia, and 87 (8.1%) oligohydramnios. Among the induced labor, 1031 (95.6%) were delivered by vaginal and 48 (4.4%) by Cesarean section. Conclusions: The prevalence of inducted labor was 18.43%. Factors associated with labor induction were maternal age, employment, residential type, and an abortion. The most common indications were premature rupture of membrane, prolonged labor, and pre-eclampsia. The successful rate was considerably higher and the frequency of cesarean sections was lower than the result of other studies.","PeriodicalId":432782,"journal":{"name":"Proceedings of the 6th International Conference on Medical and Health Informatics","volume":"179 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115408182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: Immune checkpoint inhibitors (ICIs), including anti-PD-1/L1 therapy and anti-CTLA-4 therapy, were reported with thyroid gland disorders adverse events. Recently, the FDA announced a warning that the combination of navolumab and cabozantinib can cause adrenal insufficiency. We performed a pharmacovigilance study to analyze the association between thyroid gland disorders and the use of ICI, anti-angiogenic agents or the combination treatment by mining the FDA adverse events reporting system (FAERS) database. Methods: Data were searched and analyzed in the US Food and Drug Administration Adverse Event Reporting System (FAERS) database. Thyroid gland disorders, including hypothyroidism, hyperthyroidism, autoimmune thyroiditis, were defined by the Medical Dictionary for Regulatory Activities (MedDRA). We conducted disproportionality analysis using reporting odds ratio (ROR). The result was defined as a signal if the lower limit of the 95% confidence interval for ROR is over 2, the number of cases ≥3. And additive and multiplicative models were applied to analyze drug interactions. Results: In the FAERS database, we identified 2862 cases of thyroid gland disorders, and the cases number for hyperthyroidism, hypothyroidism and thyroiditis were 767 and 1579 and 556. In the disproportionality analysis, for ICI drugs group, our study detected moderate to strong signals between ICIs and thyroid gland disorders. Among these subgroups, ICI-related thyroiditis was associated with the strongest signal (ROR 23.09 [95% CI 21.08-25.28]). As for anti-angiogenic drugs group, however, very weak signals were found between anti-angiogenic drugs and thyroid gland disorders, only hypothyroidism was found with a significant signal (ROR 4.87 [95% CI 4.60-5.16]). As for combined regimen groups, we didn't identify significantly increased signals of thyroid gland disorders than monotherapy treatment. And we didn't find interactions between ICI and anti-angiogenic drugs according to additive/multiplicative models. Conclusion: In our study, we confirmed the increased risk of thyroid gland disorders of ICIs and anti-angiogenic agents monotherapy, however, there were no increased signals when the combination therapy was used. In order to prevent serious outcomes, we should be aware of thyroid gland disorders' risk when using ICIs or anti-angiogenic agents.
目的:免疫检查点抑制剂(ICIs)，包括抗pd -1/L1治疗和抗ctla -4治疗，被报道与甲状腺疾病不良事件。最近，FDA宣布了一项警告，navolumab和cabozantinib联合使用可能导致肾上腺功能不全。我们进行了一项药物警戒研究，通过挖掘FDA不良事件报告系统(FAERS)数据库，分析甲状腺疾病与使用ICI、抗血管生成药物或联合治疗之间的关系。方法:对美国食品药品监督管理局不良事件报告系统(FAERS)数据库中的数据进行检索和分析。甲状腺疾病，包括甲状腺功能减退、甲状腺功能亢进、自身免疫性甲状腺炎，由调节活动医学词典(MedDRA)定义。我们使用报告优势比(ROR)进行歧化分析。若ROR的95%置信区间下限大于2，病例数≥3，则该结果为信号。采用加性和乘法模型分析药物相互作用。结果:在FAERS数据库中，我们发现2862例甲状腺疾病，其中甲状腺功能亢进、甲状腺功能减退和甲状腺炎分别为767例、1579例和556例。在歧化分析中，对于ICI药物组，我们的研究发现了ICI与甲状腺疾病之间中度至强烈的信号。在这些亚组中，ici相关性甲状腺炎与最强信号相关(ROR 23.09 [95% CI 21.08-25.28])。而在抗血管生成药物组，抗血管生成药物与甲状腺疾病之间的信号非常弱，只有甲状腺功能减退有显著信号(ROR 4.87 [95% CI 4.60-5.16])。至于联合治疗组，我们没有发现甲状腺疾病的信号比单药治疗明显增加。根据加法/乘法模型，我们没有发现ICI和抗血管生成药物之间的相互作用。结论:在我们的研究中，我们证实了ICIs和抗血管生成药物单独治疗会增加甲状腺疾病的风险，然而，联合治疗时没有增加信号。为了防止严重的后果，在使用ICIs或抗血管生成药物时，我们应该意识到甲状腺疾病的风险。
{"title":"Thyroid Dland Disorders Associated with Combination of Antiangiogenic Agents and Immune Checkpoint Inhibitors: A Pharmacovigilance Study","authors":"L. Zhuge","doi":"10.1145/3545729.3545766","DOIUrl":"https://doi.org/10.1145/3545729.3545766","url":null,"abstract":"Purpose: Immune checkpoint inhibitors (ICIs), including anti-PD-1/L1 therapy and anti-CTLA-4 therapy, were reported with thyroid gland disorders adverse events. Recently, the FDA announced a warning that the combination of navolumab and cabozantinib can cause adrenal insufficiency. We performed a pharmacovigilance study to analyze the association between thyroid gland disorders and the use of ICI, anti-angiogenic agents or the combination treatment by mining the FDA adverse events reporting system (FAERS) database. Methods: Data were searched and analyzed in the US Food and Drug Administration Adverse Event Reporting System (FAERS) database. Thyroid gland disorders, including hypothyroidism, hyperthyroidism, autoimmune thyroiditis, were defined by the Medical Dictionary for Regulatory Activities (MedDRA). We conducted disproportionality analysis using reporting odds ratio (ROR). The result was defined as a signal if the lower limit of the 95% confidence interval for ROR is over 2, the number of cases ≥3. And additive and multiplicative models were applied to analyze drug interactions. Results: In the FAERS database, we identified 2862 cases of thyroid gland disorders, and the cases number for hyperthyroidism, hypothyroidism and thyroiditis were 767 and 1579 and 556. In the disproportionality analysis, for ICI drugs group, our study detected moderate to strong signals between ICIs and thyroid gland disorders. Among these subgroups, ICI-related thyroiditis was associated with the strongest signal (ROR 23.09 [95% CI 21.08-25.28]). As for anti-angiogenic drugs group, however, very weak signals were found between anti-angiogenic drugs and thyroid gland disorders, only hypothyroidism was found with a significant signal (ROR 4.87 [95% CI 4.60-5.16]). As for combined regimen groups, we didn't identify significantly increased signals of thyroid gland disorders than monotherapy treatment. And we didn't find interactions between ICI and anti-angiogenic drugs according to additive/multiplicative models. Conclusion: In our study, we confirmed the increased risk of thyroid gland disorders of ICIs and anti-angiogenic agents monotherapy, however, there were no increased signals when the combination therapy was used. In order to prevent serious outcomes, we should be aware of thyroid gland disorders' risk when using ICIs or anti-angiogenic agents.","PeriodicalId":432782,"journal":{"name":"Proceedings of the 6th International Conference on Medical and Health Informatics","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124394644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Özcan, Yiling Liu, J. Vroon, Daan Kamphuis, Simone Spagnol
Good sleep is conducive to the recovery process of hospital patients – and yet, in many wards, sleep duration and quality can often be suboptimal, in part due to modifiable hospital-related sounds and noises. At the neurological ward of the Reinier de Graaf hospital in Delft, the Netherlands, we developed and evaluated a prototype information exchange system to raise awareness of specific sounds as disturbing patients’ sleep. The system both classifies different relevant sound events and tracks sleep quality (using a Fitbit device). This information is then visualized for patients and staff to present the influence of the soundscape on patients’ sleep hygiene in a friendly and comprehensive way. We discuss the design process, including a context study and various evaluations of the technology, interface, and created affordances. Our initial findings indicate that visualizing hospital soundscapes may, indeed, support both patients and staff in their efforts towards better sleep hygiene.
良好的睡眠有助于医院病人的康复过程——然而，在许多病房里，睡眠时间和质量往往不是最佳的，部分原因是与医院有关的声音和噪音可以改变。在荷兰代尔夫特Reinier de Graaf医院的神经病房，我们开发并评估了一个原型信息交换系统，以提高对干扰患者睡眠的特定声音的认识。该系统对不同的相关声音事件进行分类，并跟踪睡眠质量(使用Fitbit设备)。然后将这些信息可视化给患者和工作人员，以友好和全面的方式呈现声景对患者睡眠卫生的影响。我们讨论了设计过程，包括上下文研究和对技术、界面和创建的功能的各种评估。我们的初步研究结果表明，可视化医院的声景可能确实有助于患者和工作人员改善睡眠卫生。
{"title":"Doplor Sleep: Monitoring Hospital Soundscapes for Better Sleep Hygiene","authors":"E. Özcan, Yiling Liu, J. Vroon, Daan Kamphuis, Simone Spagnol","doi":"10.1145/3545729.3545745","DOIUrl":"https://doi.org/10.1145/3545729.3545745","url":null,"abstract":"Good sleep is conducive to the recovery process of hospital patients – and yet, in many wards, sleep duration and quality can often be suboptimal, in part due to modifiable hospital-related sounds and noises. At the neurological ward of the Reinier de Graaf hospital in Delft, the Netherlands, we developed and evaluated a prototype information exchange system to raise awareness of specific sounds as disturbing patients’ sleep. The system both classifies different relevant sound events and tracks sleep quality (using a Fitbit device). This information is then visualized for patients and staff to present the influence of the soundscape on patients’ sleep hygiene in a friendly and comprehensive way. We discuss the design process, including a context study and various evaluations of the technology, interface, and created affordances. Our initial findings indicate that visualizing hospital soundscapes may, indeed, support both patients and staff in their efforts towards better sleep hygiene.","PeriodicalId":432782,"journal":{"name":"Proceedings of the 6th International Conference on Medical and Health Informatics","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123789379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Improta, M. Illario, V. Luca, G. Annuzzi, G. Iaccarino, M. Triassi
The health technology assessment is fundamental in the acquisition of novel technologies and it is an important tool for the decision makers. With the development of novel emerging mobile-health apps, devices, software and In-formation and Communication Technologies (ICT), the evaluation over a wide range of available products is a critical issue. Here we propose a questionnaire-based approach to assess ICT tools able to facilitate the lives of people with Type 2 Diabetes Mellitus (T2DM). We used a 5-point Likert scale as a psychometric scale to assess experts’ opinions regarding novel tools for the T2DM self-management. Preliminary data collected through the administration of the questionnaire show the relative importance of the functionalities and features of the examined technologies, giving opportunities for future improvements.
{"title":"A qualitative approach for the Health Technology Assessment of IT supported Type 2 Diabetes management tools","authors":"G. Improta, M. Illario, V. Luca, G. Annuzzi, G. Iaccarino, M. Triassi","doi":"10.1145/3545729.3545792","DOIUrl":"https://doi.org/10.1145/3545729.3545792","url":null,"abstract":"The health technology assessment is fundamental in the acquisition of novel technologies and it is an important tool for the decision makers. With the development of novel emerging mobile-health apps, devices, software and In-formation and Communication Technologies (ICT), the evaluation over a wide range of available products is a critical issue. Here we propose a questionnaire-based approach to assess ICT tools able to facilitate the lives of people with Type 2 Diabetes Mellitus (T2DM). We used a 5-point Likert scale as a psychometric scale to assess experts’ opinions regarding novel tools for the T2DM self-management. Preliminary data collected through the administration of the questionnaire show the relative importance of the functionalities and features of the examined technologies, giving opportunities for future improvements.","PeriodicalId":432782,"journal":{"name":"Proceedings of the 6th International Conference on Medical and Health Informatics","volume":"141 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114251074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Alfano, I. Loperto, A. Scala, Teresa Angela Trunfio, A. Lombardi, A. Borrelli, M. Triassi, G. Improta
Background. The Covid-19 pandemic has deeply impacted the oncology community. The European Society for Medical Oncology (ESMO) suggests strengthening telemedicine services, reducing clinic visits and switching to subcutaneous or oral, rather than intravenous, therapies whenever possible. Methods. This study was conducted at the Oncology Complex Operating Unit by collecting data on all patients who accessed in 2019-2020. The aim was to understand how Covid-19 affected hospital admissions. Statistical tests and Logistic Regression were implemented. Results. The statistical analysis carried out showed that between 2019 and 2020 there was less use of emergency admission and voluntary discharge, while highlighting the increase in the "Protected with integrated home care" discharge mode. Conclusion. The results show how the European guidelines have improved the health process, from admission with the reduction of emergencies to discharge.
{"title":"Mode of discharge in CoViD-19 era: the case of the C.O.U. Oncology of “San Giovanni di Dio e Ruggi d'Aragona” University Hospital","authors":"R. Alfano, I. Loperto, A. Scala, Teresa Angela Trunfio, A. Lombardi, A. Borrelli, M. Triassi, G. Improta","doi":"10.1145/3545729.3545781","DOIUrl":"https://doi.org/10.1145/3545729.3545781","url":null,"abstract":"Background. The Covid-19 pandemic has deeply impacted the oncology community. The European Society for Medical Oncology (ESMO) suggests strengthening telemedicine services, reducing clinic visits and switching to subcutaneous or oral, rather than intravenous, therapies whenever possible. Methods. This study was conducted at the Oncology Complex Operating Unit by collecting data on all patients who accessed in 2019-2020. The aim was to understand how Covid-19 affected hospital admissions. Statistical tests and Logistic Regression were implemented. Results. The statistical analysis carried out showed that between 2019 and 2020 there was less use of emergency admission and voluntary discharge, while highlighting the increase in the \"Protected with integrated home care\" discharge mode. Conclusion. The results show how the European guidelines have improved the health process, from admission with the reduction of emergencies to discharge.","PeriodicalId":432782,"journal":{"name":"Proceedings of the 6th International Conference on Medical and Health Informatics","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124611815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Dashdavaa, N. Dambaa, B. Oidov, Khishigsuren Zuunnast
Abstract: Alcohol and tobacco use, and drug resistance have become key issues in TB care in Mongolia. Although the use of alcohol and tobacco in patients with multi-drug resistant TB (MDR-TB) has been identified, the relationship between MDR-TB treatment outcomes, alcohol and tobacco use has not yet been studied. Aim of study: To study effects of alcohol and tobacco abuse on MDR-TB treatment outcome. Methods: This is randomly assigned case control study. Patients, who enrolled in MDR-TB short regimen between 2020 and 2021, were participated in the study. Alcohol and Nicotine dependence was assessed by Nicotine dependence standard scale and AUDIT scale. Results: Of the 64 MDR-TB patients, 55% were male and the mean age of participants was 38.07±1.75 years. Based on AUDIT, 78% and 22% patients were classified as low risky, harmful, high risk level of alcohol use (Cronbach`s alpha 0.936). Conclusion: Alcohol and tobacco abuse are higher among MDR-TB patients in Mongolia. Alcohol and Nicotine dependence associated with bad treatment outcome of MDR-TB in the country.
{"title":"Effects of Alcohol and Tobacco Abuse on Multi-Drug Resistant Tuberculosis Treatment Outcome, Mongolia","authors":"D. Dashdavaa, N. Dambaa, B. Oidov, Khishigsuren Zuunnast","doi":"10.1145/3545729.3545793","DOIUrl":"https://doi.org/10.1145/3545729.3545793","url":null,"abstract":"Abstract: Alcohol and tobacco use, and drug resistance have become key issues in TB care in Mongolia. Although the use of alcohol and tobacco in patients with multi-drug resistant TB (MDR-TB) has been identified, the relationship between MDR-TB treatment outcomes, alcohol and tobacco use has not yet been studied. Aim of study: To study effects of alcohol and tobacco abuse on MDR-TB treatment outcome. Methods: This is randomly assigned case control study. Patients, who enrolled in MDR-TB short regimen between 2020 and 2021, were participated in the study. Alcohol and Nicotine dependence was assessed by Nicotine dependence standard scale and AUDIT scale. Results: Of the 64 MDR-TB patients, 55% were male and the mean age of participants was 38.07±1.75 years. Based on AUDIT, 78% and 22% patients were classified as low risky, harmful, high risk level of alcohol use (Cronbach`s alpha 0.936). Conclusion: Alcohol and tobacco abuse are higher among MDR-TB patients in Mongolia. Alcohol and Nicotine dependence associated with bad treatment outcome of MDR-TB in the country.","PeriodicalId":432782,"journal":{"name":"Proceedings of the 6th International Conference on Medical and Health Informatics","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130445269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tessa Sjahriani, D. Arivo, E. Wasito, W. Tyasningsih
The phage rz/rz1 gene is a membrane subunit that is required for phage lysis to breach the bacterial host's outer membrane. Because of their proclivity to excise and infect multiple hosts, they are key drivers of horizontal gene transfer resulting in the bacteria becoming a STEC. This study aim to looked at the rz/rz1 gene of E. coli strain STEC and Shigella sonnei carrying stx gene, yielded eight lytic bacteriophages, using PCR, DNA sequencing and NCBI Blast, Expasy translation and Expasy protparam for analyze. The rz/rz1 gene sequences were found to have 97.73 % to 98.90 % identical similarities with E. coli strain STEC and Shigella sonnei. According to the Kruskal-Wallis statistical test, there was a significant difference in rz/rz1 amino acid between Phage, E. coli strain STEC and Shigella sonnei (p < 0.001). The conclusion is the rz/rz1 gene of lytic bacteriophage was involved in the spread of stx gene, with significant difference of amino acid.
{"title":"The Analysis of Phage rz/rz1 Gene in Shigatoxin Bacteria","authors":"Tessa Sjahriani, D. Arivo, E. Wasito, W. Tyasningsih","doi":"10.1145/3545729.3545777","DOIUrl":"https://doi.org/10.1145/3545729.3545777","url":null,"abstract":"The phage rz/rz1 gene is a membrane subunit that is required for phage lysis to breach the bacterial host's outer membrane. Because of their proclivity to excise and infect multiple hosts, they are key drivers of horizontal gene transfer resulting in the bacteria becoming a STEC. This study aim to looked at the rz/rz1 gene of E. coli strain STEC and Shigella sonnei carrying stx gene, yielded eight lytic bacteriophages, using PCR, DNA sequencing and NCBI Blast, Expasy translation and Expasy protparam for analyze. The rz/rz1 gene sequences were found to have 97.73 % to 98.90 % identical similarities with E. coli strain STEC and Shigella sonnei. According to the Kruskal-Wallis statistical test, there was a significant difference in rz/rz1 amino acid between Phage, E. coli strain STEC and Shigella sonnei (p < 0.001). The conclusion is the rz/rz1 gene of lytic bacteriophage was involved in the spread of stx gene, with significant difference of amino acid.","PeriodicalId":432782,"journal":{"name":"Proceedings of the 6th International Conference on Medical and Health Informatics","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130923398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Sritart, Somchat Taertulakarn, S. Kanbara, H. Miyazaki
Healthcare facilities around the world become overwhelmed by the number of infected coronavirus patients that needed to be treated during the COVID-19 outbreak, resulting in medical staff and healthcare services shortages. Regarding to understand and minimize the inequalities in healthcare services, it is crucial to evaluate the available healthcare resource, particularly the intensive care unit (ICU) beds that are critical for the COVID-19 pandemic. Therefore, this study aims to explore and determine the spatial distribution of the confirmed COVID-19 patients and the healthcare capacities in the province of Ubon Ratchathani, Thailand. Applying the GIS platform with the data analysis of 2SFCA (Two-Step Floating Catchment Area) based approach, we emphasize the spatial distribution of both patients and healthcare resources in the study area. The spatial accessibility index regarding the physicians and ICU beds was determined and highlighted in each district. Additionally, the vulnerable regions were identified by the level of healthcare accessibility. We believe this study offers valuable insight in gaining a better understanding and supporting effective response activities toward pandemic resilience.
{"title":"Spatial equity and healthcare access in the COVID-19 pandemic","authors":"H. Sritart, Somchat Taertulakarn, S. Kanbara, H. Miyazaki","doi":"10.1145/3545729.3545782","DOIUrl":"https://doi.org/10.1145/3545729.3545782","url":null,"abstract":"Healthcare facilities around the world become overwhelmed by the number of infected coronavirus patients that needed to be treated during the COVID-19 outbreak, resulting in medical staff and healthcare services shortages. Regarding to understand and minimize the inequalities in healthcare services, it is crucial to evaluate the available healthcare resource, particularly the intensive care unit (ICU) beds that are critical for the COVID-19 pandemic. Therefore, this study aims to explore and determine the spatial distribution of the confirmed COVID-19 patients and the healthcare capacities in the province of Ubon Ratchathani, Thailand. Applying the GIS platform with the data analysis of 2SFCA (Two-Step Floating Catchment Area) based approach, we emphasize the spatial distribution of both patients and healthcare resources in the study area. The spatial accessibility index regarding the physicians and ICU beds was determined and highlighted in each district. Additionally, the vulnerable regions were identified by the level of healthcare accessibility. We believe this study offers valuable insight in gaining a better understanding and supporting effective response activities toward pandemic resilience.","PeriodicalId":432782,"journal":{"name":"Proceedings of the 6th International Conference on Medical and Health Informatics","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115639260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amirul Amalia, H. Hendarto, Arifa Mustika, Inta Susanti
Objective. Nigella sativa is a plant that contains a lot of antioxidants. Nigella sativa is an important medicinal herb that has been utilized for centuries. Given Nigella sativa efficacy in treating a variety of disorders, this systematic study attempts to assess Nigella sativa effect on the female reproductive system. Materials and methods. This systematic review was conducted on the Randomize Control Trial (RCT) through electronic databases such as Google Scholar, Science Direct, Pubmed, Scopus and Proquest from January 2012 to January 2022. The keywords or phrases used were Nigella sativa, Black Seeds, Black Cumin, Thymoquinonee, Infertility, Women dan Female. Results. 14 articles were selected for analysis. The results showed that Nigella sativa and its constituent, Thymoquinone can reduce MDA levels, increase SOD, increase TAS, increase the number of ovarian follicles, and increase body weight. Conclusion. Nigella sativa can improve reproductive parameters in women.
{"title":"Effects of Nigella Sativa on Female Infertility: A Systematic Review","authors":"Amirul Amalia, H. Hendarto, Arifa Mustika, Inta Susanti","doi":"10.1145/3545729.3545776","DOIUrl":"https://doi.org/10.1145/3545729.3545776","url":null,"abstract":"Objective. Nigella sativa is a plant that contains a lot of antioxidants. Nigella sativa is an important medicinal herb that has been utilized for centuries. Given Nigella sativa efficacy in treating a variety of disorders, this systematic study attempts to assess Nigella sativa effect on the female reproductive system. Materials and methods. This systematic review was conducted on the Randomize Control Trial (RCT) through electronic databases such as Google Scholar, Science Direct, Pubmed, Scopus and Proquest from January 2012 to January 2022. The keywords or phrases used were Nigella sativa, Black Seeds, Black Cumin, Thymoquinonee, Infertility, Women dan Female. Results. 14 articles were selected for analysis. The results showed that Nigella sativa and its constituent, Thymoquinone can reduce MDA levels, increase SOD, increase TAS, increase the number of ovarian follicles, and increase body weight. Conclusion. Nigella sativa can improve reproductive parameters in women.","PeriodicalId":432782,"journal":{"name":"Proceedings of the 6th International Conference on Medical and Health Informatics","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122103872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Madurapperumage A. Erandathi, William Yu Chung Wang, Michael Mayo, I. Shafiu
Exploring the sociodemographic factors of a cohort is a vital phase in revealing significant aspects of the societal health status. The health care sector utilises the results of exploratory analysis of the sociodemographic nature to fulfil various purposes such as constructing health care policies, allocating adequate resources, imposing necessary medications and many more. A large and growing body of evidence shows that understanding the pervasiveness of sociodemographic factors: age, ethnicity, gender, reveal crucial information. Therefore, this study aims to disclose the knowledge through analysing the sociodemographic details of a New Zealand diabetes cohort. Diabetes mellitus is a chronic fatal disease that occurs due to the inability to control proper blood sugar levels, which causes multitudinous acute and chronic complications. Diabetes became a high prevalence disease in the region of Waikato. Analysing the cohort of diabetes patients associated with complications of diabetes illustrate the prevalence of complications of diabetes among the patients. The dataset of the study has been collected from the Waikato district health board. This study intends to report the initial scanning of the dataset profile with visualising the resulting patterns of sociodemographic details from the samples and their association with complications of diabetes. The Sankey diagrams use to visualise the results of exploratory data analysis. The resulted graphs of the data screening descriptively illustrate the characteristics of the cohort associated with demographic factors. Maori population shows higher percentage (0.68) of diabetes patients than the other ethnicities, while having narrower age expansion (13-95) with early onset age, compared to others (20-103). Males (0.61%) are more vulnerable to diabetes than females (0.55%). Additionally, hypertension and cardiovascular diseases are common among the diabetes patients’ in the Waikato region. Maori male population is highly vulnerable to diabetes. This study will be beneficial in constructing and analysing the demographical categories of the cohort to comparatively study the pervasiveness of the diseases among resulting classes.
{"title":"Prevalence of sociodemographic factors in a cohort of diabetes mellitus: a retrospective study","authors":"Madurapperumage A. Erandathi, William Yu Chung Wang, Michael Mayo, I. Shafiu","doi":"10.1145/3545729.3545768","DOIUrl":"https://doi.org/10.1145/3545729.3545768","url":null,"abstract":"Exploring the sociodemographic factors of a cohort is a vital phase in revealing significant aspects of the societal health status. The health care sector utilises the results of exploratory analysis of the sociodemographic nature to fulfil various purposes such as constructing health care policies, allocating adequate resources, imposing necessary medications and many more. A large and growing body of evidence shows that understanding the pervasiveness of sociodemographic factors: age, ethnicity, gender, reveal crucial information. Therefore, this study aims to disclose the knowledge through analysing the sociodemographic details of a New Zealand diabetes cohort. Diabetes mellitus is a chronic fatal disease that occurs due to the inability to control proper blood sugar levels, which causes multitudinous acute and chronic complications. Diabetes became a high prevalence disease in the region of Waikato. Analysing the cohort of diabetes patients associated with complications of diabetes illustrate the prevalence of complications of diabetes among the patients. The dataset of the study has been collected from the Waikato district health board. This study intends to report the initial scanning of the dataset profile with visualising the resulting patterns of sociodemographic details from the samples and their association with complications of diabetes. The Sankey diagrams use to visualise the results of exploratory data analysis. The resulted graphs of the data screening descriptively illustrate the characteristics of the cohort associated with demographic factors. Maori population shows higher percentage (0.68) of diabetes patients than the other ethnicities, while having narrower age expansion (13-95) with early onset age, compared to others (20-103). Males (0.61%) are more vulnerable to diabetes than females (0.55%). Additionally, hypertension and cardiovascular diseases are common among the diabetes patients’ in the Waikato region. Maori male population is highly vulnerable to diabetes. This study will be beneficial in constructing and analysing the demographical categories of the cohort to comparatively study the pervasiveness of the diseases among resulting classes.","PeriodicalId":432782,"journal":{"name":"Proceedings of the 6th International Conference on Medical and Health Informatics","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115097579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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