{"title":"Cross-Sectional Survey of Adulterated Sexual Enhancement Products Sold in the Sacramento Area of California","authors":"Tessa Fischer, Jenna Tucker, Charlie Li, Kyungmi Min, Dadong Xu, Laurence Upjohn, Madhur Kumar","doi":"10.2147/nds.s409032","DOIUrl":"https://doi.org/10.2147/nds.s409032","url":null,"abstract":"","PeriodicalId":43423,"journal":{"name":"Nutrition and Dietary Supplements","volume":" 21","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138609798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahendra Trivedi, Alice Branton, Dahryn Trivedi, Sambhu Mondal, Snehasis Jana
Background: Cannabidiol (CBD) is a non-psychoactive cannabinoid derived from Cannabis sativa L. with very low toxicity for human and a wide variety of therapeutic uses as medicine. The study objective is to evaluate the impact of CBD on vitamin D 3 receptor (VDR) protein expressions, tissue elasticity, anti-inflammatory, and anti-senescence activity in human and rodent cell lines. Methods: Cell viability was estimated by MTT assay. Relative quantification (RQ) of VDR protein expression was measured by RT-PCR. Tissue elasticity was measured by atomic force microscopy (AFM). Cellular senescence and ATP were performed using trypan blue exclusion test and colorimetric assay, respectively. Results: Cell viability assay data showed CBD was safe and nontoxic upto 7.5 μM. The VDR protein expression was significantly increased by 109.71% ( p = 0.013), 236.96% ( p ≤ 0.001), 170% ( p ≤ 0.001), 100% ( p = 0.019), 80% ( p = 0.021), 427.27% ( p ≤ 0.001), 366.67% ( p ≤ 0.001), 56.31% ( p = 0.016), and 63.84% ( p ≤ 0.001) in MG-63, MDA-MB-231, SH-SY5Y, HEK-293, HT-29, EaHy-926, HepG2, A-549, and C2C12 cells, respectively compared to the normal control group. CBD treatment significantly reduced the levels of TNF-α (46.58%; p ≤ 0.049) and IL-6 (43.61%; p ≤ 0.001) at CBD-5 μM compared to the vehicle control group. Tissue elasticity was significantly ( p ≤ 0.001) increased by 37.09% and 49.49% in CBD-2.5 and CBD-5 μM, respectively, compared to the vehicle control group. Significantly ( p ≤ 0.001) reduced senescence cells by 39.22% in CBD-5 μM than the vehicle control group. The level of ATP was significantly ( p ≤ 0.001) increased by 90.55, 117.06, and 153.54% in CBD-1, CBD-2.5, and CBD-5 μM, respectively, compared to the vehicle control group. Conclusion: Overall, data suggest that CBD considerably improved VDR protein expression, inflammation, cell growth, tissue elasticity, and enhanced mitochondrial bioenergetics in multiple cell lines. In this study, for the first time, we showed the evidence suggesting that the VDR plays a critical and multifaceted role in various types of human cells. Keywords: cannabidiol, inflammation, elasticity, VDR expression, senescence, ATP
{"title":"Cannabidiol (CBD) Upregulates Vitamin D3 Receptors (VDRs) Expression That Modulates Cytokines (TNF-α, IL-6), Tissue Elasticity, Cellular Senescence, and Mitochondrial ATP Generation in Human and Rodent Cell Lines","authors":"Mahendra Trivedi, Alice Branton, Dahryn Trivedi, Sambhu Mondal, Snehasis Jana","doi":"10.2147/nds.s435447","DOIUrl":"https://doi.org/10.2147/nds.s435447","url":null,"abstract":"Background: Cannabidiol (CBD) is a non-psychoactive cannabinoid derived from Cannabis sativa L. with very low toxicity for human and a wide variety of therapeutic uses as medicine. The study objective is to evaluate the impact of CBD on vitamin D 3 receptor (VDR) protein expressions, tissue elasticity, anti-inflammatory, and anti-senescence activity in human and rodent cell lines. Methods: Cell viability was estimated by MTT assay. Relative quantification (RQ) of VDR protein expression was measured by RT-PCR. Tissue elasticity was measured by atomic force microscopy (AFM). Cellular senescence and ATP were performed using trypan blue exclusion test and colorimetric assay, respectively. Results: Cell viability assay data showed CBD was safe and nontoxic upto 7.5 μM. The VDR protein expression was significantly increased by 109.71% ( p = 0.013), 236.96% ( p ≤ 0.001), 170% ( p ≤ 0.001), 100% ( p = 0.019), 80% ( p = 0.021), 427.27% ( p ≤ 0.001), 366.67% ( p ≤ 0.001), 56.31% ( p = 0.016), and 63.84% ( p ≤ 0.001) in MG-63, MDA-MB-231, SH-SY5Y, HEK-293, HT-29, EaHy-926, HepG2, A-549, and C2C12 cells, respectively compared to the normal control group. CBD treatment significantly reduced the levels of TNF-α (46.58%; p ≤ 0.049) and IL-6 (43.61%; p ≤ 0.001) at CBD-5 μM compared to the vehicle control group. Tissue elasticity was significantly ( p ≤ 0.001) increased by 37.09% and 49.49% in CBD-2.5 and CBD-5 μM, respectively, compared to the vehicle control group. Significantly ( p ≤ 0.001) reduced senescence cells by 39.22% in CBD-5 μM than the vehicle control group. The level of ATP was significantly ( p ≤ 0.001) increased by 90.55, 117.06, and 153.54% in CBD-1, CBD-2.5, and CBD-5 μM, respectively, compared to the vehicle control group. Conclusion: Overall, data suggest that CBD considerably improved VDR protein expression, inflammation, cell growth, tissue elasticity, and enhanced mitochondrial bioenergetics in multiple cell lines. In this study, for the first time, we showed the evidence suggesting that the VDR plays a critical and multifaceted role in various types of human cells. Keywords: cannabidiol, inflammation, elasticity, VDR expression, senescence, ATP","PeriodicalId":43423,"journal":{"name":"Nutrition and Dietary Supplements","volume":"58 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135456283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Amaranths have an immense nutrition potential to alleviate malnutrition problems. However, since amaranth cultivation and production in Ethiopia is highly scarce, its impact to lessen the malnutrition problem has not been explored to its maximum potential. This review assesses the potential role of amaranth crops for nutrition security in Ethiopia. Worldwide yield of amaranth is about 35–40 tons/ha while in Ethiopia it is still 2.25 tons/ha which is 17 times lower than the world average. Amaranth is described by its nutritious and gluten-free grain that contains a significant amount of protein, which ranges between 14% and 17%, fat (5–9%) and starch (62%). However, the highest biological value of amaranth protein was reported to be 75–79%. It can also be used in savory dishes as well as sweet breakfast, porridge, salads, and baked breads in different countries. However, amaranth is not extensively cultivated in Africa and merely South Africa is conducting large researches and grand projects in a wider scope. It is a neglected crop especially in Ethiopia. Amaranth production is still at the beginning or low stage. The government also losses its focus of attention on amaranth to solve nutrition insecurity in Ethiopia. Thus, to produce amaranth crop in a broader range and use it as a key solution for malnutrition problems in Ethiopia, comprehensive varietal adaptation, continuous training, and strong market linkage should be given attention by the concerned bodies such as research institutes, industries, non-governmental organizations and ministerial bureaus.
{"title":"A Review of Amaranth Crop as a Potential Solution to Ethiopia’s Nutritional Crisis","authors":"Yohannes Gelaye","doi":"10.2147/nds.s428058","DOIUrl":"https://doi.org/10.2147/nds.s428058","url":null,"abstract":": Amaranths have an immense nutrition potential to alleviate malnutrition problems. However, since amaranth cultivation and production in Ethiopia is highly scarce, its impact to lessen the malnutrition problem has not been explored to its maximum potential. This review assesses the potential role of amaranth crops for nutrition security in Ethiopia. Worldwide yield of amaranth is about 35–40 tons/ha while in Ethiopia it is still 2.25 tons/ha which is 17 times lower than the world average. Amaranth is described by its nutritious and gluten-free grain that contains a significant amount of protein, which ranges between 14% and 17%, fat (5–9%) and starch (62%). However, the highest biological value of amaranth protein was reported to be 75–79%. It can also be used in savory dishes as well as sweet breakfast, porridge, salads, and baked breads in different countries. However, amaranth is not extensively cultivated in Africa and merely South Africa is conducting large researches and grand projects in a wider scope. It is a neglected crop especially in Ethiopia. Amaranth production is still at the beginning or low stage. The government also losses its focus of attention on amaranth to solve nutrition insecurity in Ethiopia. Thus, to produce amaranth crop in a broader range and use it as a key solution for malnutrition problems in Ethiopia, comprehensive varietal adaptation, continuous training, and strong market linkage should be given attention by the concerned bodies such as research institutes, industries, non-governmental organizations and ministerial bureaus.","PeriodicalId":43423,"journal":{"name":"Nutrition and Dietary Supplements","volume":"3 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139305126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Mdoe, Venkatesh Mannar, M. Justine, Godfrey Guga, Rose Gadiye, Vincent Assey, Caroline Kimathi, Fatma Abdallah, John Paschal, E. Mduma, Levente Diosady
{"title":"Effectiveness of Quadruple Fortified Salt Compared to Double and Single Fortified Salts in Improving Haemoglobin Levels Among Moderately Anemic Women Aged 18–49 Years in Rural Low Resource Setting: Randomized Clinical Trial","authors":"P. Mdoe, Venkatesh Mannar, M. Justine, Godfrey Guga, Rose Gadiye, Vincent Assey, Caroline Kimathi, Fatma Abdallah, John Paschal, E. Mduma, Levente Diosady","doi":"10.2147/nds.s412893","DOIUrl":"https://doi.org/10.2147/nds.s412893","url":null,"abstract":"","PeriodicalId":43423,"journal":{"name":"Nutrition and Dietary Supplements","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45579035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nur Zakiah Mohd Saat, Ruzita Abd Talib, S. Alarsan, N. Saadeh, Ghada Shahrour
{"title":"Risk Factors of Overweight and Obesity Among School Children Aged 6 to 18 Years: A Scoping Review","authors":"Nur Zakiah Mohd Saat, Ruzita Abd Talib, S. Alarsan, N. Saadeh, Ghada Shahrour","doi":"10.2147/nds.s420370","DOIUrl":"https://doi.org/10.2147/nds.s420370","url":null,"abstract":"","PeriodicalId":43423,"journal":{"name":"Nutrition and Dietary Supplements","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48648632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gut Microbiota Composition in Indian and Western Infants (0–24 Months): A Systematic Review","authors":"","doi":"10.2147/nds.s402256","DOIUrl":"https://doi.org/10.2147/nds.s402256","url":null,"abstract":"","PeriodicalId":43423,"journal":{"name":"Nutrition and Dietary Supplements","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47596847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quality and Nutrient Loss in the Cooking Vegetable and Its Implications for Food and Nutrition Security in Ethiopia: A Review","authors":"Yohannes Gelaye","doi":"10.2147/nds.s404651","DOIUrl":"https://doi.org/10.2147/nds.s404651","url":null,"abstract":"","PeriodicalId":43423,"journal":{"name":"Nutrition and Dietary Supplements","volume":"1 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44557191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eneyew Talie Fenta, Misganaw Guadie Tiruneh, T. Anagaw
{"title":"Exploring Enablers and Barriers of Healthy Dietary Behavior Based on the Socio-Ecological Model, a Qualitative Systematic Review","authors":"Eneyew Talie Fenta, Misganaw Guadie Tiruneh, T. Anagaw","doi":"10.2147/nds.s395444","DOIUrl":"https://doi.org/10.2147/nds.s395444","url":null,"abstract":"","PeriodicalId":43423,"journal":{"name":"Nutrition and Dietary Supplements","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45148823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hiwot Berhanu, Berhe Gebremichael, K. Roba, Sisay Moges, Merhawi Gebremedhin
{"title":"Drivers of Food Choice Among College Students in Addis Ababa, Ethiopia: A Structural Equation Model","authors":"Hiwot Berhanu, Berhe Gebremichael, K. Roba, Sisay Moges, Merhawi Gebremedhin","doi":"10.2147/nds.s379563","DOIUrl":"https://doi.org/10.2147/nds.s379563","url":null,"abstract":"","PeriodicalId":43423,"journal":{"name":"Nutrition and Dietary Supplements","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47654677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Abebe, Getachew Redae Taffere, Meseret Abay Fisseha, Afework Mulugeta
{"title":"Risk Factors and Spatial Distributions of Underweight Among Children Under-Five in Urban and Rural Communities in Tigray, Northern Ethiopia: Using Ordinal Logistic Regression Analysis","authors":"H. Abebe, Getachew Redae Taffere, Meseret Abay Fisseha, Afework Mulugeta","doi":"10.2147/nds.s371773","DOIUrl":"https://doi.org/10.2147/nds.s371773","url":null,"abstract":"","PeriodicalId":43423,"journal":{"name":"Nutrition and Dietary Supplements","volume":"1 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43143533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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