I. Cakir, V. Karataşlı, V. Gülseren, D. Ayaz, Barış Sever, Zübeyde EMİRALİOĞLU ÇAKIR, Gökşen Görgülü, O. Kuru, M. Şancı, M. Gökçü
{"title":"The Prognostic Significance of Preoperative Cancer Antigen-125 Levels in Uterine Papillary Serous Carcinomas","authors":"I. Cakir, V. Karataşlı, V. Gülseren, D. Ayaz, Barış Sever, Zübeyde EMİRALİOĞLU ÇAKIR, Gökşen Görgülü, O. Kuru, M. Şancı, M. Gökçü","doi":"10.5505/aot.2022.98624","DOIUrl":"https://doi.org/10.5505/aot.2022.98624","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130166610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Akagunduz, Didem Ikiz, B. Akbelen, S. Alanyalı, A. Haydaroglu, A. Aras, Z. Özsaran
INTRODUCTION: In this study, local recurrence rates and prognostic factors was investigated in patients with ductal carcinoma in situ (DCIS) after breast conserving surgery (BCS) and adjuvant radiotherapy (RT) and compared with Eastern Cooperative Oncology Group (ECOG) Study E5194. METHODS: Totally 96 patients were evaluated retrospectively. Prognostic factors that might influence local control (age, tumor size, surgical margins, nuclear grade, comedo necrosis, hormone receptor status) were investigated. The eligibility criteria of ECOG 5194 were stratified into two groups as in the original study and were compared for local control. RESULTS: The median follow-up time was 62 ay (8-139) months. Local recurrence was observed in 5 patients who had 2 (%2.1) invasive carcinoma and 3 (%3.1) DCIS. Ten years local control rate was 89%. In the recurrence of local disease, the age of 50 years, estrogen (ER) receptor negativity, c-erb-B2 positivity was found to be significant (respectively p=0.020, p=0.014, p=0.022). According to the ECOG study, Group 1 and Group 2, which are considered to be low risk groups, and these two groups were compared with those who were not included in these two groups; there was no difference in both comparisons (p> 0.05). DISCUSSION AND CONCLUSION: Prognostic factors affecting local control in DCIS have been age and hormone receptor status. When 10-year results were compared with the ECOG 5194, adjuvant RT produced an absolute difference of 10% in low-intermediate and high grade in local control.
{"title":"Results of Local Recurrence in Patient with Breast Ductal Carcinoma In situ and Comparison with Low-Risk Groups in ECOG 5194 Study","authors":"O. Akagunduz, Didem Ikiz, B. Akbelen, S. Alanyalı, A. Haydaroglu, A. Aras, Z. Özsaran","doi":"10.5505/AOT.2019.48039","DOIUrl":"https://doi.org/10.5505/AOT.2019.48039","url":null,"abstract":"INTRODUCTION: In this study, local recurrence rates and prognostic factors was investigated in patients with ductal carcinoma in situ (DCIS) after breast conserving surgery (BCS) and adjuvant radiotherapy (RT) and compared with Eastern Cooperative Oncology Group (ECOG) Study E5194. METHODS: Totally 96 patients were evaluated retrospectively. Prognostic factors that might influence local control (age, tumor size, surgical margins, nuclear grade, comedo necrosis, hormone receptor status) were investigated. The eligibility criteria of ECOG 5194 were stratified into two groups as in the original study and were compared for local control. RESULTS: The median follow-up time was 62 ay (8-139) months. Local recurrence was observed in 5 patients who had 2 (%2.1) invasive carcinoma and 3 (%3.1) DCIS. Ten years local control rate was 89%. In the recurrence of local disease, the age of 50 years, estrogen (ER) receptor negativity, c-erb-B2 positivity was found to be significant (respectively p=0.020, p=0.014, p=0.022). According to the ECOG study, Group 1 and Group 2, which are considered to be low risk groups, and these two groups were compared with those who were not included in these two groups; there was no difference in both comparisons (p> 0.05). DISCUSSION AND CONCLUSION: Prognostic factors affecting local control in DCIS have been age and hormone receptor status. When 10-year results were compared with the ECOG 5194, adjuvant RT produced an absolute difference of 10% in low-intermediate and high grade in local control.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134598778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bahar Uncu Ulu, D. Şahin, T. Yiğenoğlu, T. Darçın, M. Bakırtaş, S. Başcı, J. Yıldız, D. İskender, N. A. Baysal, M. Kızıl Çakar, M. Dal, F. Altuntaş
Introduction: Primary central nervous system lymphomas (PCNSL) are defined as a rare extranodal Non-Hodgkin lymphoma subgroup. The induction regimens involve high dose methotrexate-based chemotherapies mostly for the patients with PCNSL. There is still no standard approach for consolidation therapy. Recently, consolidation with autologous stem cell transplantation (ASCT) after high-dose chemotherapy has been widely used in the treatment of PCNSL. We aim to evaluate the results of PCNS patients who underwent ASCT in our center. Methods: The data of PCNSL patients diagnosed in Hematology Unit of Dr. Abdurrahman Yurtaslan Ankara Oncology Hospital between 2010 and 2021 were analyzed retrospectively. Results: Eleven patients were diagnosed with PCNSL diagnosis. The patients' median age included in the study was 53.5 years (range 38-68). Eight patients underwent ASCT for upfront consolidation. Seven patients achieved CR three months after ASCT; one patient was not evaluated due to exitus in the first month of the transplant. Three patients could not achieve ASCT due to transplantation ineligibility patients and mobilization failure. The median follow-up period in the study was 26 months (range 8-82 months). The median overall survival was not reached. Transplant-related mortality was 12.5%, and the mortality rate was 27% in the whole cohort. In patients who received ASCT, of the 62.5% had an almost two-year survival advantage. For the whole cohort, 73% of the patients had change for more prolonged survival among follow-up. Discussion and conclusion: In our cohort, the PCNSL patients had mostly high-risk disease; however, three-quarters of the patients could receive ASCT, and at the same rate of the patients had advantages for long-term survival.
{"title":"Consolidation With Autologous Stem Cell Transplantation In Patients With Primary Central Nervous System Lymphoma","authors":"Bahar Uncu Ulu, D. Şahin, T. Yiğenoğlu, T. Darçın, M. Bakırtaş, S. Başcı, J. Yıldız, D. İskender, N. A. Baysal, M. Kızıl Çakar, M. Dal, F. Altuntaş","doi":"10.5505/aot.2021.09821","DOIUrl":"https://doi.org/10.5505/aot.2021.09821","url":null,"abstract":"Introduction: Primary central nervous system lymphomas (PCNSL) are defined as a rare extranodal Non-Hodgkin lymphoma subgroup. The induction regimens involve high dose methotrexate-based chemotherapies mostly for the patients with PCNSL. There is still no standard approach for consolidation therapy. Recently, consolidation with autologous stem cell transplantation (ASCT) after high-dose chemotherapy has been widely used in the treatment of PCNSL. We aim to evaluate the results of PCNS patients who underwent ASCT in our center. Methods: The data of PCNSL patients diagnosed in Hematology Unit of Dr. Abdurrahman Yurtaslan Ankara Oncology Hospital between 2010 and 2021 were analyzed retrospectively. Results: Eleven patients were diagnosed with PCNSL diagnosis. The patients' median age included in the study was 53.5 years (range 38-68). Eight patients underwent ASCT for upfront consolidation. Seven patients achieved CR three months after ASCT; one patient was not evaluated due to exitus in the first month of the transplant. Three patients could not achieve ASCT due to transplantation ineligibility patients and mobilization failure. The median follow-up period in the study was 26 months (range 8-82 months). The median overall survival was not reached. Transplant-related mortality was 12.5%, and the mortality rate was 27% in the whole cohort. In patients who received ASCT, of the 62.5% had an almost two-year survival advantage. For the whole cohort, 73% of the patients had change for more prolonged survival among follow-up. Discussion and conclusion: In our cohort, the PCNSL patients had mostly high-risk disease; however, three-quarters of the patients could receive ASCT, and at the same rate of the patients had advantages for long-term survival.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131891684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cutaneous Squamous Cell Carcinoma: A Type Of Cancer That Discriminates Against Young Adults","authors":"Z. Güç, Hasan Güç","doi":"10.5505/aot.2023.61582","DOIUrl":"https://doi.org/10.5505/aot.2023.61582","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130689786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
INTRODUCTION: In this study, we aimed to analyze the clinical observation and surgical results of the patients having bone invasion suspected with imaging methods invasion with preoperatively having soft tissue
前言:本研究旨在分析影像学检查怀疑骨侵犯且术前有软组织侵犯的患者的临床观察及手术结果
{"title":"Management of suspected cases of soft tissue sarcoma, bone invasion: 16 Case Study","authors":"G. Toğral, B. Ş. Güngör","doi":"10.5505/aot.2019.09226","DOIUrl":"https://doi.org/10.5505/aot.2019.09226","url":null,"abstract":"INTRODUCTION: In this study, we aimed to analyze the clinical observation and surgical results of the patients having bone invasion suspected with imaging methods invasion with preoperatively having soft tissue","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133387454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. A. Öztürk, M. Albayrak, Ç. Pala, S. Maral, A. Yıldız, O. Şahin, Pınar Cömert
INTRODUCTION: We aimed to assess patients with chronic lymphocytic leukemia (CLL) with respect to their general clinical features, first-line treatments, survival time, and factors affecting treatment response. METHODS: This study retrospectively enrolled 169 patients with available medical records of 188 patients who were under follow-up with CLL at Training and Research Hospital, Department of Hematology between
{"title":"Assessment of Clinical Course, Prognostic Features, and Treatment Response of Patients with Chronic Lymphocytic Leukemia: A Single Center Experience","authors":"H. A. Öztürk, M. Albayrak, Ç. Pala, S. Maral, A. Yıldız, O. Şahin, Pınar Cömert","doi":"10.5505/aot.2019.41033","DOIUrl":"https://doi.org/10.5505/aot.2019.41033","url":null,"abstract":"INTRODUCTION: We aimed to assess patients with chronic lymphocytic leukemia (CLL) with respect to their general clinical features, first-line treatments, survival time, and factors affecting treatment response. METHODS: This study retrospectively enrolled 169 patients with available medical records of 188 patients who were under follow-up with CLL at Training and Research Hospital, Department of Hematology between","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132578583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparision of Radiation-induced Secondary Malignancy Risk Between Intensity Modulated Radiotherapy and Volumetric Modulated Arc Therapy with Simultaneous Integrated Boost in the Treatment of Nasopharyngeal Carcinoma","authors":"E. Haciislamoglu","doi":"10.5505/aot.2019.49379","DOIUrl":"https://doi.org/10.5505/aot.2019.49379","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124200259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of Factors Associated With Retinal Hemorrhage In Patients With Acute Leukemia","authors":"S. Özdoğan, A. Çelik, S. Başcı","doi":"10.5505/aot.2022.97992","DOIUrl":"https://doi.org/10.5505/aot.2022.97992","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114362735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Crizotinib extends survival in ALK-positive advanced NSCLC: Single center experience","authors":"E. Çubukçu, N. Koca, T. Kaçan, A. Deligönül","doi":"10.5505/aot.2019.59254","DOIUrl":"https://doi.org/10.5505/aot.2019.59254","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"2013 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114808122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. G. Bilgetekin, S. Yüksel, K. Demir, Orhan Kunu, H. Atilla, Önder Ersan
{"title":"Early Functional and Radiological Results of Mau Osteotomy for Moderate-Severe Hallux Valgus Deformity","authors":"Y. G. Bilgetekin, S. Yüksel, K. Demir, Orhan Kunu, H. Atilla, Önder Ersan","doi":"10.5505/AOT.2020.90692","DOIUrl":"https://doi.org/10.5505/AOT.2020.90692","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116269096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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