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Retrospective evaluation of brain metastates in lung cancer patients treated with stereotactic radiosurgery alone 单纯立体定向放射治疗肺癌患者脑转移的回顾性评价

Acta Oncologica Turcica

Pub Date : 1900-01-01 DOI: 10.5505/aot.2019.30932

S. Değirmencioğlu, O. Unal, E. Oktay, A. Demiray, M. Arslan, H. Aslan, E. Sağtaş, B. Y. Taskoylu, Ilker Kiraz, G. Dogu, A. Yaren

INTRODUCTION: Due to new systemic treatment modalities, overall survival in lung cancer is increasing. Incidence of brain metastases in lung cancer are more common for this reason. The utilisation of stereotactic radiosurgery for one and oligo (two-four) brain metastases, has provided this treatment strategy as a promt treatment alternative. In this study we aimed to investigate the efficiency of stereotactic radiosurgery in lung cancer patients with brain metastasis, the effectiveness of adding diffusion magnetic resonance imaging (MRI) to conventional MRI for treatment evaluation and the relationship between clinical parameters retrospectively. METHODS: Seventy-nine lung cancer patients treated between January 2016 and December 2017 in our clinic with stereotactic radiosurgery whose eastern cooperative oncology group (ECOG) performance status were 0-1 and had less than 5 brain metastases, has retrsopectively analysed. RESULTS: The median age of patients was 59 years (43-78). Diffusion MRI has provided no more benefit for evaluation of treatment. There was no statistically significant mortality difference between subgroups of small cell and non small cell lung carcinoma. The presence of extracranial metastases has shortened the overall survival time significantly (p=0,042). DISCUSSION AND CONCLUSION: The lung cancer patients with brain metastases have histopathological and genetic heterogenity. Multivariate analysis showed the presence of extracranial metastases had only unfavorable impact on overall survival in our study. Orijinal Çalışma 204 Adress for correspondence: Dr. Öğr. Üyesi Serkan Değirmencioğlu, Pamukkale Üniversitesi Hastanesi Fahri Gökşin Onkoloji Merkezi Üniversite sokak no: 7 Bağbaşı 20160 Denizli Türkiye e-mail: sdegirmencioglu@pau.edu.tr Available at www.actaoncologicaturcica.com Copyright ©Ankara Onkoloji Hastanesi

导读:由于新的全身治疗方式，肺癌的总生存率正在提高。由于这个原因，肺癌脑转移的发生率更常见。利用立体定向放射外科治疗一个和少(2 - 4)脑转移，提供了这种治疗策略作为一种及时的治疗选择。本研究旨在回顾性探讨立体定向放射手术治疗肺癌脑转移患者的有效性，在常规MRI基础上增加扩散磁共振成像(MRI)进行治疗评价的有效性以及临床参数之间的关系。方法:回顾性分析2016年1月至2017年12月在我院行立体定向放射外科治疗的79例肺癌患者，其东部肿瘤合作组(ECOG)评分为0-1分，脑转移少于5例。结果:患者中位年龄为59岁(43-78岁)。弥散性MRI对治疗评价没有更多的益处。小细胞肺癌与非小细胞肺癌亚组间死亡率无统计学差异。颅外转移的存在显著缩短了总生存时间(p= 0.042)。讨论与结论:肺癌脑转移患者具有组织病理学和遗传异质性。多因素分析显示，在我们的研究中，颅外转移的存在对总生存只有不利的影响。原件Çalışma 204通信地址:Dr. Öğr。Üyesi Serkan Değirmencioğlu, Pamukkale Üniversitesi Hastanesi Fahri Gökşin Onkoloji Merkezi Üniversite sokak no: 7 Bağbaşı 20160 Denizli t rkiye e-mail: sdegirmencioglu@pau.edu.tr提供www.actaoncologicaturcica.com版权所有©安卡拉Onkoloji Hastanesi

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引用次数: 0

Investigation of BRCA2 Gene K3326X Variant in Patients with Breast and Ovarian Cancer by Next-Generation Sequencing Technique 应用新一代测序技术研究乳腺癌和卵巢癌患者BRCA2基因K3326X变异

Acta Oncologica Turcica

Pub Date : 1900-01-01 DOI: 10.5505/aot.2023.68815

Neslihan Düzkale, C. Karaçin, S. Yörübulut, H. Erdem, Özlem Öz, M. Altınbaş

Introduction: The BRCA2 gene is a tumor suppressor gene involved in the repair of double-stranded DNA damage by homologous recombination. Until now, many cancer-related variants of the BRCA2 gene have been reported. There are conflicting publications in studies of the possible effect of the K3326X variant of this gene in cancer. This study investigates the K3326X BRCA2 gene variant and its role in the cancer pathogenesis of Turkish patients diagnosed with breast and ovarian cancer. Materials and methods: In the study, 1957 patients with cancer diagnosis for BRCA1 and BRCA2 genetic analysis and 432 healthy individuals without a history of cancer were included. The K3326X variant was investigated using the next-generation sequencing method from the genomic DNA sample obtained from the individuals. Results: K3326X variant was detected in 54 of 1957 (2.75%) cancer patients. For the non-cancerous group, 11 of 432 (2.5%) patients were carrying the K3326X variant. When both groups were compared in terms of K3326X variant carriage, a statistically significant result could not be obtained for the individuals (p=0.934). Discussion: BRCA2 K3326X variant did not have a significant role in cancer etiopathogenesis. As a result, the variant whose clinical significance is not still been fully understood, was investigated for the first time for Turkish population. Our results suggest that the variant could be a benign variant.

BRCA2基因是一种肿瘤抑制基因，通过同源重组参与双链DNA损伤的修复。到目前为止，已经报道了许多与癌症相关的BRCA2基因变异。关于该基因的K3326X变体在癌症中的可能影响的研究中，有相互矛盾的出版物。本研究探讨了K3326X BRCA2基因变异及其在土耳其乳腺癌和卵巢癌患者癌症发病机制中的作用。材料和方法:本研究纳入1957例经BRCA1和BRCA2基因分析诊断为癌症的患者和432例无癌症病史的健康个体。利用新一代测序方法从个体基因组DNA样本中研究K3326X变异。结果:1957例肿瘤患者中检出K3326X变异54例(2.75%)。对于非癌组，432例患者中有11例(2.5%)携带K3326X变体。两组K3326X变异携带量比较，个体间差异无统计学意义(p=0.934)。讨论:BRCA2 K3326X变异在癌症发病中没有显著作用。结果，临床意义尚未完全了解的变异，首次在土耳其人群中进行了调查。我们的结果表明，这种变异可能是一种良性变异。

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引用次数: 0

Investigation of Clinical and Histopathological Features in Invasive Lobular Breast Cancers 浸润性小叶性乳腺癌的临床和组织病理学特征研究

Acta Oncologica Turcica

Pub Date : 1900-01-01 DOI: 10.5505/aot.2023.92678

Giray Akgül, E. Esen, M. Turan, Ş. B. Morkavuk, Simay Akyüz, Yasin Gülap, Pelin Seçken, M. Gülçelik

引用次数: 0

A Rare Case of Multiple Primary Malignancy Diagnosed with Pancreatic Adenocarcinoma After Diffuse Large B Cell Lymphoma 一例罕见的多发性原发恶性肿瘤在弥漫性大B细胞淋巴瘤后被诊断为胰腺腺癌

Acta Oncologica Turcica

Pub Date : 1900-01-01 DOI: 10.5505/aot.2019.26879

A. Kutlucan, L. Kutlucan, Esra Zeynep Coşkunoğlu, A. Basturk

引用次数: 0

Efficacy of Pazopanib in Patients with Pretreated Advanced Stage Soft Tissue Sarcomas 帕唑帕尼治疗晚期软组织肉瘤的疗效

Acta Oncologica Turcica

Pub Date : 1900-01-01 DOI: 10.5505/aot.2022.37108

M. Aykan, G. Keskin, Ece Ornek, Alper Topal, Çağlar Köseoğlu, Aysegul Dumludag, İ. Ertürk, N. Karadurmuş

引用次数: 1

Assessment of complications after anesthesia in the postanesthetic care unit of the oncology hospital 肿瘤医院麻醉后护理单元麻醉后并发症的评估

Acta Oncologica Turcica

Pub Date : 1900-01-01 DOI: 10.5505/AOT.2019.49344

S. Ölmez, M. Kaya, D. Kalayci, S. Yılmaz, E. Eskiçırak, S. Ünver

引用次数: 0

The effect of metastatic focus on survival after cytoreductive nephrectomy in renal cell carcinoma: Experience of a single center 转移灶对肾细胞癌减数切除后存活的影响:单一中心的经验

Acta Oncologica Turcica

Pub Date : 1900-01-01 DOI: 10.5505/aot.2019.48403

I. Selvi, E. Öztürk

引用次数: 0

The predictive value of FDG-PET / CT in assessing bone marrow involvement in Hodgkin Lymphoma patients; A single center experience FDG-PET / CT对霍奇金淋巴瘤患者骨髓受累的预测价值单中心体验

Acta Oncologica Turcica

Pub Date : 1900-01-01 DOI: 10.5505/aot.2021.08941

Merih Reis Aras, M. Albayrak, A. Yıldız, S. Maral, H. B. Afacan Öztürk, P. Akyol, M. Tığlıoğlu, B. Sağlam, F. Yılmaz

引用次数: 0

Diverting Ostomies and their Complications in Mechanical Colorectal Anastomosis for Rectum Cancer: Retrospective Study 直肠癌机械结直肠吻合术中转移造口术及其并发症的回顾性研究

Acta Oncologica Turcica

Pub Date : 1900-01-01 DOI: 10.5505/aot.2019.26213

B. Öndeş, N. Karaman, B. Aksel, C. Ozaslan

INTRODUCTION: Anastomotic leakage after low anterior resection is the most serious complication and increases the morbidity and mortality rates and prolonges length of stay. In this study, the effectiveness and safety of diverting ostomies in colorectal anastomosis was compared retrospectively. METHODS: The charts of all patients with diverting ostomies operated with extraperitoneal colorectal or coloanal anastomosis electively due to rectal adenocarcinoma between 2005-2010 were examined retrospectively. RESULTS: A total of 101 patients were included in the study. Twentynine (28.7%) patients were given neoadjuvant chemoradiotherapy (NAKRT). Diverting ostomy was applied to 33 of the patients (32.7%) in the study group. Diverting ileostomy was performed to 33 (93.9%) of these patients, colostomy in the remaining two. Diverting ostomy was applied to 14 of 29 patients (48.2%) treated with NAKRT (p = 0.03). While the diverting ostomy was applied in 31 patients with BMI ≥25, it was used only in two patients with BMI <25 (p = 0.0001). Surgical site infection was the most frequent complication in 24 patients (23.8%). Stoma related complications were observed in 23 patients (69.6%). Additional treatments for dehydration were needed in 4 (12.2%) patients. Parastomal skin infections were observed in 14 of 31 patients (45%) with ileostomy DISCUSSION AND CONCLUSION: In this series of patients, the diverting ostomy applications were found to Orijinal Çalışma 304 Adress for correspondence: Angora Evleri Ressamlar Caddesi F6 Blok Daire 8 Beysukent 06800 Ankara Türkiye e-mail: niyazikaraman@hotmail.com Available at www.actaoncologicaturcica.com Copyright ©Ankara Onkoloji Hastanesi be more frequent in patients with BMI ≥ 25 and treated with NAKRT. In this series of patients, the most common stoma complications were; skin irritations (42.4%), dehydration (12.1%), stoma bleeding (6.1%), mucocutaneous dehiscence (6.1%) and the need for stoma revision (3%). In terms of these complications care should be taken in patients undergoing diverting ostomy.

前言:低位前切除术后吻合口漏是最严重的并发症，增加了发病率和死亡率，延长了住院时间。本研究回顾性比较了直肠吻合术中转口术的有效性和安全性。方法:回顾性分析2005-2010年因直肠腺癌择期行转移造口术行结肠或结肠外吻合术的病例。结果:共纳入101例患者。29例(28.7%)患者接受新辅助放化疗(NAKRT)。研究组中有33例(32.7%)患者行转移造口术。其中33例(93.9%)行回肠造口术，其余2例行结肠造口术。29例接受NAKRT治疗的患者中有14例(48.2%)采用了转移造口术(p = 0.03)。31例BMI≥25的患者采用转流造口术，2例BMI <25的患者采用转流造口术(p = 0.0001)。手术部位感染是最常见的并发症，24例(23.8%)。造口相关并发症23例(69.6%)。4例(12.2%)患者需要额外的脱水治疗。讨论与结论:在这一系列患者中，发现转道造口应用于原文Çalışma 304通信地址:Angora Evleri Ressamlar Caddesi F6 block Daire 8 Beysukent 06800 Ankara trkiye e-mail: niyazikaraman@hotmail.com可在www.actaoncologicaturcica.com版权©Ankara Onkoloji Hastanesi在BMI≥25且接受NAKRT治疗的患者中更常见。在这组患者中，最常见的造口并发症是;皮肤刺激(42.4%)，脱水(12.1%)，造口出血(6.1%)，粘膜皮肤开裂(6.1%)和需要造口修复(3%)。在这些并发症方面，患者应采取转移造口术。

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引用次数: 0

Molecular Characterization Reveals the Importance and Diversity of Germline and Somatic RET Mutations in Cancer 分子特征揭示了生殖系和体细胞RET突变在癌症中的重要性和多样性

Acta Oncologica Turcica

Pub Date : 1900-01-01 DOI: 10.5505/aot.2021.25932

I. Sahin, H. Erdem

引用次数: 0

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