INTRODUCTION: In this study, we aimed to compare the superiority of infiltration analgesia and pectoral nerve block methods on pain scores, total opioid consumption and discharge time from post anesthesia care unit (PACU) of patients after oncologic mastectomy. METHODS: After approval of the ethics committee and patient consent, sixty patients who underwent mastectomy for breast cancer between 18-80 years of age were included in the study. Patients were divided into two groups, who underwent pectoral nerve block for postoperative analgesia as Group I and infiltration analgesia as Group II. Intraoperative tenoxicam of 20 mg was applied to all patients. Postoperative pain was evaluated with Visual Analog Scala (VAS) at the 1st, 6th, 12th and 24th hours. Patients with a VAS of more than 3 were given tramadol 1 mg/kg and morphine (05-1 mg) if necessary. In the first 24 hours postoperatively, total analgesic consumption, discharge time from PACU, rates of nausea, vomiting and other side effects of patients were recorded and results were evaluated statistically. RESULTS: Demographic characteristics were similar in two groups. Postoperative VAS scores were significantly lower in the pectoral nerve block group at the 1st, 6th, 12th and 24th hours compared to the infiltration analgesia group. The total analgesic consumption, nauseavomiting rate, and discharge time from PACU were significantly lower in the pectoral nerve block group. DISCUSSION AND CONCLUSION: In our study, pectoral nerve block method was found superior to infiltration analgesia method on postoperative pain management in oncologic breast surgery. In conclusion, we recommend the pectoral nerve block to supply effective pain management and early discharge time from PACU after mastectomy for breast cancer.
{"title":"Comparison of infiltration analgesia and pectoral nerve block in the pain management after mastectomy for breast cancer","authors":"G. Argun, İ. Kaya, S. Ünver","doi":"10.5505/aot.2019.26928","DOIUrl":"https://doi.org/10.5505/aot.2019.26928","url":null,"abstract":"INTRODUCTION: In this study, we aimed to compare the superiority of infiltration analgesia and pectoral nerve block methods on pain scores, total opioid consumption and discharge time from post anesthesia care unit (PACU) of patients after oncologic mastectomy. METHODS: After approval of the ethics committee and patient consent, sixty patients who underwent mastectomy for breast cancer between 18-80 years of age were included in the study. Patients were divided into two groups, who underwent pectoral nerve block for postoperative analgesia as Group I and infiltration analgesia as Group II. Intraoperative tenoxicam of 20 mg was applied to all patients. Postoperative pain was evaluated with Visual Analog Scala (VAS) at the 1st, 6th, 12th and 24th hours. Patients with a VAS of more than 3 were given tramadol 1 mg/kg and morphine (05-1 mg) if necessary. In the first 24 hours postoperatively, total analgesic consumption, discharge time from PACU, rates of nausea, vomiting and other side effects of patients were recorded and results were evaluated statistically. RESULTS: Demographic characteristics were similar in two groups. Postoperative VAS scores were significantly lower in the pectoral nerve block group at the 1st, 6th, 12th and 24th hours compared to the infiltration analgesia group. The total analgesic consumption, nauseavomiting rate, and discharge time from PACU were significantly lower in the pectoral nerve block group. DISCUSSION AND CONCLUSION: In our study, pectoral nerve block method was found superior to infiltration analgesia method on postoperative pain management in oncologic breast surgery. In conclusion, we recommend the pectoral nerve block to supply effective pain management and early discharge time from PACU after mastectomy for breast cancer.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124421410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hilal Korkmaz, Mustafa Akşar, Halis Doğukan Özkan, V. Korkmaz, N. Boran
Background: Comparison of predictive values of complete blood count inflammatory parameters and serum CA-125 levels in the differential diagnosis of patients with epithelial ovarian tumor (EOTs) diagnosed in the reproductive period. Materials: In this study, 105 women patients in the reproductive period were retrospectively analyzed. The patients included were examined in terms of clinical, laboratory and pathological features. Results: The mean age of the patients was 41.5 ± 8.6 years and BMI was 28.6 ± 5.8 kg/m2. Of the whole study population, 54 (51.5%) were benign EOTs, 18 (17.1%) were borderline EOTs and 33 (31.4%) were malignant EOTs. When comparing these three tumor groups, a significant difference was found in terms of serum CA-125 [14.7 U/mL (2.7-238.6) vs 60.2 U/mL (7.8 – 557) vs 416.5 U/mL (2.4-7695), p<0.001, respectively], platelet count [294 x103/ μL (133-744) vs 303, x103/ μL (160-468) vs 383 x103/ μL (128-725), p = 0.018, respectively], neutrophil count [4.2, x103/ μL (1.9 -8.9) vs 4.9 x103/ μL (2.610.9) vs 5.1 x103/ μL (2.2 – 10.7), p = 0.012], neutrophil-to-lymphocyte ratio (NLR) [2.1 (0.1-8.2) vs 2.6 (1.2 – 5.9) vs 3.1 (1-6.8), p = 0.021, respectively] and platelet-to-lymphocyte ratio (PLR) [154.4 (82.1-658.4) vs 168.1 (91.1-377.8) vs 201.5 (29.6-499.2), p = 0.008, respectively] values. In the ROC analyses, serum CA-125 levels (AUC= 0.818, p <0.001), platelet count (AUC= 0.673, p = 0.005) and PLR (AUC= 0.690, p = 0.002) values significantly predicted malignant EOTs. Conclusion: Preoperative platelet count, neutrophil count and PLR predict epithelial ovarian cancers significantly. However, diagnostic predictive values of all three parameters are lower than CA-125. Therefore, CA-125 is still the most valuable serum biochemical marker that can be used in the preoperative differential diagnosis of EOTs.
背景:全血细胞计数、炎症参数和血清CA-125水平在生殖期卵巢上皮性肿瘤(EOTs)鉴别诊断中的预测价值的比较。资料:本研究对105例育龄期女性患者进行回顾性分析。对入选患者进行临床、实验室及病理检查。结果:患者平均年龄41.5±8.6岁，BMI 28.6±5.8 kg/m2。在整个研究人群中，54例(51.5%)为良性EOTs, 18例(17.1%)为边缘性EOTs, 33例(31.4%)为恶性EOTs。3组患者血清CA-125 [14.7 U/mL (2.7 ~ 238.6) vs 60.2 U/mL (7.8 ~ 557) vs 416.5 U/mL (2.4 ~ 7695)， p<0.001]、血小板计数[294 x103/ μL (133 ~ 744) vs 303 x103/ μL (160 ~ 468) vs 383 x103/ μL (128 ~ 725)， p = 0.018]、中性粒细胞计数[4.2,x103/ μL (1.9 ~ 8.9) vs 4.9 x103/ μL (2.610.9) vs 5.1 x103/ μL (2.2 ~ 10.7)， p = 0.012]、中性粒细胞与淋巴细胞比值(NLR) [2.1 (0.1-8.2) vs 2.6 (1.2 - 5.9) vs 3.1 (1-6.8)， p = 0.021]和血小板与淋巴细胞比值(PLR) [154.4 (82.1-658.4) vs 168.1 (91.1-377.8) vs 2010.5 (29.6-499.2)， p = 0.008]值。在ROC分析中，血清CA-125水平(AUC= 0.818, p <0.001)、血小板计数(AUC= 0.673, p = 0.005)和PLR (AUC= 0.690, p = 0.002)值可显著预测恶性eot。结论:术前血小板计数、中性粒细胞计数和PLR对上皮性卵巢癌有显著预测作用。然而，这三个参数的诊断预测值均低于CA-125。因此，CA-125仍是EOTs术前鉴别诊断中最有价值的血清生化指标。
{"title":"Predictive Value of Complete Blood Count Inflammatory Parameters for Epithelial Ovarian Cancers in Women During Reproductive Period","authors":"Hilal Korkmaz, Mustafa Akşar, Halis Doğukan Özkan, V. Korkmaz, N. Boran","doi":"10.5505/aot.2021.30922","DOIUrl":"https://doi.org/10.5505/aot.2021.30922","url":null,"abstract":"Background: Comparison of predictive values of complete blood count inflammatory parameters and serum CA-125 levels in the differential diagnosis of patients with epithelial ovarian tumor (EOTs) diagnosed in the reproductive period. Materials: In this study, 105 women patients in the reproductive period were retrospectively analyzed. The patients included were examined in terms of clinical, laboratory and pathological features. Results: The mean age of the patients was 41.5 ± 8.6 years and BMI was 28.6 ± 5.8 kg/m2. Of the whole study population, 54 (51.5%) were benign EOTs, 18 (17.1%) were borderline EOTs and 33 (31.4%) were malignant EOTs. When comparing these three tumor groups, a significant difference was found in terms of serum CA-125 [14.7 U/mL (2.7-238.6) vs 60.2 U/mL (7.8 – 557) vs 416.5 U/mL (2.4-7695), p<0.001, respectively], platelet count [294 x103/ μL (133-744) vs 303, x103/ μL (160-468) vs 383 x103/ μL (128-725), p = 0.018, respectively], neutrophil count [4.2, x103/ μL (1.9 -8.9) vs 4.9 x103/ μL (2.610.9) vs 5.1 x103/ μL (2.2 – 10.7), p = 0.012], neutrophil-to-lymphocyte ratio (NLR) [2.1 (0.1-8.2) vs 2.6 (1.2 – 5.9) vs 3.1 (1-6.8), p = 0.021, respectively] and platelet-to-lymphocyte ratio (PLR) [154.4 (82.1-658.4) vs 168.1 (91.1-377.8) vs 201.5 (29.6-499.2), p = 0.008, respectively] values. In the ROC analyses, serum CA-125 levels (AUC= 0.818, p <0.001), platelet count (AUC= 0.673, p = 0.005) and PLR (AUC= 0.690, p = 0.002) values significantly predicted malignant EOTs. Conclusion: Preoperative platelet count, neutrophil count and PLR predict epithelial ovarian cancers significantly. However, diagnostic predictive values of all three parameters are lower than CA-125. Therefore, CA-125 is still the most valuable serum biochemical marker that can be used in the preoperative differential diagnosis of EOTs.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133515886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: This cross-sectional study aims to determine the frequency of kinesiophobia in breast cancer survivors and evaluate its relationship with mainly quality of life and comorbidities, also fatigue, lymphedema, and depression. Material Methods: This study included 54 women with breast cancer who were followed in remission in Aydın Atatürk State Hospital Medical Oncology Clinic between November-December 2020. Clinicopathological characteristics of the patients were recorded. Kinesiophobia was assessed using the Turkish version of Tampa Scale for Kinesiophobia (TSK). Lymphedema was evaluated with bilateral upper extremity measurements. Depressive status and quality of life were determined using the Beck Depression Inventory (BDI) and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Version 3.0 (EORTC QLQ-C30 v3). Comorbidities were assessed using the Charlson Comorbidity Index (CCI) while fatigue was evaluated by 10 cm visual analogue scale (VAS). The relationship between the TSK and CCI, BDI, VAS-F, EORTC-30 were investigated. Results: The mean age of patients was 52.11±11.10 years. Of the patients, 36 (66.7%) had kinesiophobia based on having TSK scores above 37. The rate to recieve adjuvant radiotherapy was higher in kinesiophobic group. Kinesiophobic patients had statistically significantly lower global health, physical functioning, and emotional functioning scores, and higher depression and VAS-fatigue scores. Kinesiophobic patients also had higher financial difficulty and higher sypmtom scale scores. Comorbidities and presence of lymphedema did not differ between groups (p>0.05). All EORTC QLQ30 sub-parameter scores except for financial difficulty and symptom severity had negative significant correlations with TSK scores while VAS-fatigue, BDI, EORTC QLQ-30 symptom scale, and financial difficulties showed significant positive correlations. TSK score was not correlated with CCI. Conclusion: Kinesiophobia is rather frequent in breast cancer survivors and has associations with worse quality of life and higher depression and fatigue scores. These patients should be trained and encouraged for an active life style.
{"title":"Kinesiophobia in Breast Cancer Survivors and its Relationship with Quality of Life, Comorbidity, and other clinical parameters","authors":"I. Sunar, V. Sunar","doi":"10.5505/aot.2021.38243","DOIUrl":"https://doi.org/10.5505/aot.2021.38243","url":null,"abstract":"Objectives: This cross-sectional study aims to determine the frequency of kinesiophobia in breast cancer survivors and evaluate its relationship with mainly quality of life and comorbidities, also fatigue, lymphedema, and depression. Material Methods: This study included 54 women with breast cancer who were followed in remission in Aydın Atatürk State Hospital Medical Oncology Clinic between November-December 2020. Clinicopathological characteristics of the patients were recorded. Kinesiophobia was assessed using the Turkish version of Tampa Scale for Kinesiophobia (TSK). Lymphedema was evaluated with bilateral upper extremity measurements. Depressive status and quality of life were determined using the Beck Depression Inventory (BDI) and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Version 3.0 (EORTC QLQ-C30 v3). Comorbidities were assessed using the Charlson Comorbidity Index (CCI) while fatigue was evaluated by 10 cm visual analogue scale (VAS). The relationship between the TSK and CCI, BDI, VAS-F, EORTC-30 were investigated. Results: The mean age of patients was 52.11±11.10 years. Of the patients, 36 (66.7%) had kinesiophobia based on having TSK scores above 37. The rate to recieve adjuvant radiotherapy was higher in kinesiophobic group. Kinesiophobic patients had statistically significantly lower global health, physical functioning, and emotional functioning scores, and higher depression and VAS-fatigue scores. Kinesiophobic patients also had higher financial difficulty and higher sypmtom scale scores. Comorbidities and presence of lymphedema did not differ between groups (p>0.05). All EORTC QLQ30 sub-parameter scores except for financial difficulty and symptom severity had negative significant correlations with TSK scores while VAS-fatigue, BDI, EORTC QLQ-30 symptom scale, and financial difficulties showed significant positive correlations. TSK score was not correlated with CCI. Conclusion: Kinesiophobia is rather frequent in breast cancer survivors and has associations with worse quality of life and higher depression and fatigue scores. These patients should be trained and encouraged for an active life style.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130977844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
INTRODUCTION: Retrocaval ureter (RU) is a rare congenital anomaly characterized by the passage of the ureter through the posterior of the vena cava. We aimed to present the data of 8 cases treated with open surgical repair without excision of the retrocaval segment. METHODS: Eight patients who were operated with the diagnosis of RU in our clinic between 2005-2018 were included in the study. Demographic data, periand postoperative data of the patients were recorded and evaluated. In addition, imaging modalities were recorded. Preand postoperative values of T1⁄2 values in dynamic scintigraphy were compared. All patients underwent open ureterouretereral anostomosis without excision of the retrocaval segment. SPSS 22.0 was used for statistical analysis and p values less than 0.05 were considered statistically significant. RESULTS: Five patients were male and 3 were female. The mean age was 36.2 years (25-48). The mean operation time was 64 minutes (58-92). Six patients (75%) presented with flank pain. The mean hospitalization duration was 2.32 days. In the postoperative period, all patients underwent computed tomography-urography and dynamic and static renal scintigraphy with nuclear medicine study. There was no statistically significant difference between preoperative and postoperative static scintigraphy values (p = 0.741), but dynamic renal scintigraphy difference was significant (T1⁄2 was 25.7 min. preoperatively and 14.4 min. postoperatively, p = 0.016). DISCUSSION AND CONCLUSION: Re-anostomosis performed for the retrocaval ureter without any excision of the retrocaval segment yields successful results with minimal postoperative morbidity and short hospital stay.
{"title":"Open Surgical Repair of Retrocaval Ureter Without Excision of Retrocaval Segment: Results of 8 Cases in a Single-Center","authors":"F. Kızılay, S. Kalemci, A. Şimşir, B. Semerci","doi":"10.5505/aot.2019.95866","DOIUrl":"https://doi.org/10.5505/aot.2019.95866","url":null,"abstract":"INTRODUCTION: Retrocaval ureter (RU) is a rare congenital anomaly characterized by the passage of the ureter through the posterior of the vena cava. We aimed to present the data of 8 cases treated with open surgical repair without excision of the retrocaval segment. METHODS: Eight patients who were operated with the diagnosis of RU in our clinic between 2005-2018 were included in the study. Demographic data, periand postoperative data of the patients were recorded and evaluated. In addition, imaging modalities were recorded. Preand postoperative values of T1⁄2 values in dynamic scintigraphy were compared. All patients underwent open ureterouretereral anostomosis without excision of the retrocaval segment. SPSS 22.0 was used for statistical analysis and p values less than 0.05 were considered statistically significant. RESULTS: Five patients were male and 3 were female. The mean age was 36.2 years (25-48). The mean operation time was 64 minutes (58-92). Six patients (75%) presented with flank pain. The mean hospitalization duration was 2.32 days. In the postoperative period, all patients underwent computed tomography-urography and dynamic and static renal scintigraphy with nuclear medicine study. There was no statistically significant difference between preoperative and postoperative static scintigraphy values (p = 0.741), but dynamic renal scintigraphy difference was significant (T1⁄2 was 25.7 min. preoperatively and 14.4 min. postoperatively, p = 0.016). DISCUSSION AND CONCLUSION: Re-anostomosis performed for the retrocaval ureter without any excision of the retrocaval segment yields successful results with minimal postoperative morbidity and short hospital stay.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130281442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Changes in rectum volume can affect dose delivery during prostate radiotherapy. The aim of this study was to evaluate how laxative use affected rectum volumes and doses in patients with prostate cancer treated with Volumetric Modulated Arc Therapy (VMAT). Material and Methods: Treatment planning computed tomography (simCT) and cone-beam computed tomography (CBCT) images collected from 20 patients with prostate cancer were retrospectively evaluated. These patients were divided into two groups as those who either used or did not use laxatives during radiotherapy. Rectum volumes were re-contoured on 160 CBCT images, and VMAT treatment plans were re-calculated to determine rectum doses. Results: In all patients, CBCT images showed increased mean rectum volumes and doses relative to simCT images. Furthermore, the percent volume (Vx) of the rectum receiving 40, 50, 60, and 70 Gy doses based on CBCT results were larger than those based on simCT. The Dmean values in the treatment plans for the group with laxative use were 39 Gy on simCT images and 43 Gy on CBCT images (p = 0.009). Alternatively, in the group without laxatives, the Dmean values in the treatment plans were 40 Gy on simCT images and 44 Gy on CBCT images (p = 0.047). Conclusion: In patients undergoing prostate radiotherapy, rectum volume and doses increase regardless of laxative use. Although laxatives can limit volume expansion of the rectum, they do not have the expected effect on rectum doses and actually significantly increase all dosimetric parameters.
{"title":"The Effects of Laxative Use on Rectum Volume and Doses During Radiotherapy in Patients With Prostate Cancer","authors":"E. Duman, N. Atabek, Y. Bilek","doi":"10.5505/aot.2021.15493","DOIUrl":"https://doi.org/10.5505/aot.2021.15493","url":null,"abstract":"Objective: Changes in rectum volume can affect dose delivery during prostate radiotherapy. The aim of this study was to evaluate how laxative use affected rectum volumes and doses in patients with prostate cancer treated with Volumetric Modulated Arc Therapy (VMAT). Material and Methods: Treatment planning computed tomography (simCT) and cone-beam computed tomography (CBCT) images collected from 20 patients with prostate cancer were retrospectively evaluated. These patients were divided into two groups as those who either used or did not use laxatives during radiotherapy. Rectum volumes were re-contoured on 160 CBCT images, and VMAT treatment plans were re-calculated to determine rectum doses. Results: In all patients, CBCT images showed increased mean rectum volumes and doses relative to simCT images. Furthermore, the percent volume (Vx) of the rectum receiving 40, 50, 60, and 70 Gy doses based on CBCT results were larger than those based on simCT. The Dmean values in the treatment plans for the group with laxative use were 39 Gy on simCT images and 43 Gy on CBCT images (p = 0.009). Alternatively, in the group without laxatives, the Dmean values in the treatment plans were 40 Gy on simCT images and 44 Gy on CBCT images (p = 0.047). Conclusion: In patients undergoing prostate radiotherapy, rectum volume and doses increase regardless of laxative use. Although laxatives can limit volume expansion of the rectum, they do not have the expected effect on rectum doses and actually significantly increase all dosimetric parameters.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"16 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113965230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Merve Durna, A. Topçu, I. Yurtsever, M. Şimşek, M. Aydın, M. Seker
Adrenocortical carcinoma (ACC) is an uncommon and aggressive tumor. Despite the current treatment options commonly used in ACC, the prognosis is poor. No risk factors have been identified except for genetic predisposition. The most important factors affecting the prognosis are the stage at the time of diagnosis and the resectability of the primary tumor. Here, we present a metastatic ACC case of a 29-year-old woman presented with symptoms of swelling in her feet, abdominal striae, and mild abdominal pain for three months. The abdominal computed tomography scan revealed a 14 cm mass in the right adrenal gland, indistinguishable from the liver and right kidney. Clinicians should consider primary ACC, which has limited treatment options, in the differential diagnosis in the presence of findings such as edema, obesity, and striae.
{"title":"A Giant Metastatic Adrenal Cortical Carcinoma Case Presented with Rapid Progression","authors":"Merve Durna, A. Topçu, I. Yurtsever, M. Şimşek, M. Aydın, M. Seker","doi":"10.5505/aot.2023.57984","DOIUrl":"https://doi.org/10.5505/aot.2023.57984","url":null,"abstract":"Adrenocortical carcinoma (ACC) is an uncommon and aggressive tumor. Despite the current treatment options commonly used in ACC, the prognosis is poor. No risk factors have been identified except for genetic predisposition. The most important factors affecting the prognosis are the stage at the time of diagnosis and the resectability of the primary tumor. Here, we present a metastatic ACC case of a 29-year-old woman presented with symptoms of swelling in her feet, abdominal striae, and mild abdominal pain for three months. The abdominal computed tomography scan revealed a 14 cm mass in the right adrenal gland, indistinguishable from the liver and right kidney. Clinicians should consider primary ACC, which has limited treatment options, in the differential diagnosis in the presence of findings such as edema, obesity, and striae.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121195740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"CALR, JAK2 and MPL Genes Mutations in Myeloproliferative Neoplasms, Single Center Experience","authors":"T. Bahşi, T. Yiğenoğlu","doi":"10.5505/aot.2019.03521","DOIUrl":"https://doi.org/10.5505/aot.2019.03521","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129260168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Tekinalp, Hilal Akay Çizmecioğlu, M. H. Göktepe, Sinan Demircioğlu, Ali Kürşat Tuna, M. Karakurt Eryılmaz
{"title":"The Impact of non-COVID-19 Infections to COVID-19 Disease in Hematological and Solid Organ Malignancies","authors":"A. Tekinalp, Hilal Akay Çizmecioğlu, M. H. Göktepe, Sinan Demircioğlu, Ali Kürşat Tuna, M. Karakurt Eryılmaz","doi":"10.5505/aot.2022.03206","DOIUrl":"https://doi.org/10.5505/aot.2022.03206","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128588330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nephrogenic adenoma is a rare benign lesion of urothelial mucosa. Our case is an incidentally detected nephrogenic adenoma accompanied by bilateral hydronephrosis. A 59-year-old female. At cystoscopy, suspicious papillary lesion measuring 1 cm was observed on anteior wall of the bladder and transurethral resection was performed.Pathologically, the result was reported as nephrogenic adenoma (nephrogenic metaplasia). The urinary bladder is the most common location of nephrogenic adenom (68.6 %)and it is followed by the urethra (13.5 %),ureter (8.2%), renal pelvis (8.2%) and prostate (2%). Nephrogenic adenomas are strongly associated with chronic irritation or inflammation of the urinary tract. Other malign lesions should be distinguished immunohistochemically and histopathologically. It should be followed for concomitant malignant lesions and frequent local recurrences.
{"title":"Nephrogenic adenoma of the bladder: a case report","authors":"S. Şenel, C. S. Gökkaya, S. Kayaçetin, S. Bulut","doi":"10.5505/AOT.2019.66487","DOIUrl":"https://doi.org/10.5505/AOT.2019.66487","url":null,"abstract":"Nephrogenic adenoma is a rare benign lesion of urothelial mucosa. Our case is an incidentally detected nephrogenic adenoma accompanied by bilateral hydronephrosis. A 59-year-old female. At cystoscopy, suspicious papillary lesion measuring 1 cm was observed on anteior wall of the bladder and transurethral resection was performed.Pathologically, the result was reported as nephrogenic adenoma (nephrogenic metaplasia). The urinary bladder is the most common location of nephrogenic adenom (68.6 %)and it is followed by the urethra (13.5 %),ureter (8.2%), renal pelvis (8.2%) and prostate (2%). Nephrogenic adenomas are strongly associated with chronic irritation or inflammation of the urinary tract. Other malign lesions should be distinguished immunohistochemically and histopathologically. It should be followed for concomitant malignant lesions and frequent local recurrences.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128554636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The inflammatory myofibroblastic tumor is rarely located in the breast and, surgical resection is enough for the diagnosis and treatment. Case Report: The patient, a 64-year-old female, was referred to our centre palpable mass in the right breast. Mammography demonstrated a mass of smoothed contour with calcification in the right breast. After three months, segmental mastectomy was planned as the mass grew. Pathological features, micromorphological and immunohistochemical staining have confirmed the lesion as being breast inflammatory myofibroblastic tumor. Conclusion: Inflammatory myofibroblastic tumor of the breast is a rare and intermediate (rarely metastasizing) malignant potential tumor. Due to recurrence and metastasis risk, complete excision with negative margins and regular follow up plays a critical role in treating of inflammatory myofibroblastic tumors.
{"title":"Inflammatory Myofibroblastic Tumor of the Breast in 64 – Year – Old Women","authors":"E. Güner, F. Markoç, C. Özaslan","doi":"10.5505/aot.2022.32848","DOIUrl":"https://doi.org/10.5505/aot.2022.32848","url":null,"abstract":"Introduction: The inflammatory myofibroblastic tumor is rarely located in the breast and, surgical resection is enough for the diagnosis and treatment. Case Report: The patient, a 64-year-old female, was referred to our centre palpable mass in the right breast. Mammography demonstrated a mass of smoothed contour with calcification in the right breast. After three months, segmental mastectomy was planned as the mass grew. Pathological features, micromorphological and immunohistochemical staining have confirmed the lesion as being breast inflammatory myofibroblastic tumor. Conclusion: Inflammatory myofibroblastic tumor of the breast is a rare and intermediate (rarely metastasizing) malignant potential tumor. Due to recurrence and metastasis risk, complete excision with negative margins and regular follow up plays a critical role in treating of inflammatory myofibroblastic tumors.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129380853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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