O. Aycan, Muhammet Alptekin Kocaoğlu, M. Arslan, M. Mert, Alper Köksal
Aim: The aim of this study is to evaluate significance of Magnetic Resonance Imaging (MRI) characteristics and their effects on surgical margins, prognosis, oncological and functional outcomes of parosteal osteosarcoma in our clinic. Patients and method: Fifteen patients (4 male/11 female) who operated with the diagnosis of parosteal osteosarcoma in our clinic were retrospectively reviewed. The epidemiological data, biopsy method and delay in diagnosis are noted. The lesions maximum circumferential extension, intramedullary involvement and neurovascular extension in MRI sections were evaluated. The resection type (segmental articular/hemicortical) and surgical margins were noted. Functional and oncological results at last follow-up were assessed. Results: The mean age was 31.7 (17-71) years; mean follow-up was 50.1 (24-176) months. The most common site was distal femur. The closed biopsies were related with increased number of re-biopsies and misdiagnosis/improper interventions. (p<0.001,p=0.023) Intramedullary involvement percentage was related with maximum circumferential extension percentage (p=0.006) The intramedullary involvement ratio of ≤25% suggested no recurrence or metastasis. The mean MSTS score was 87.8% (range, 60-100%). The neurovascular involvement was related with metastatic disease, deep infections and complication related surgeries. (p=0.017, p=0.002,p=0.005) The most common resection type was segmental articular resection (9 patients). Hemicortical resections with biological reconstructions had the best MSTS scores. (p=0.002) The maximum circumferential extension percentage, intramedullary involvement percentage and neurovascular involvement showed lower MSTS scores. The 5-year overall survival was 92.3%, local recurrence-free survival was 86.2% and metastasis-free survival was 86.2%. Conclusion: The reliability of needle biopsy sampling is controversial in parosteal osteosarcomas. The lesions extent of intramedullary involvement, neurovascular bundle proximity and maximum periosteal circumferential extension on MRI should be considered when planning the surgery. The evaluation of maximum circumferential extension on MRI is crucial for the resection margins.
{"title":"Parosteal Osteosarcoma: Radiologic and Prognostic Features","authors":"O. Aycan, Muhammet Alptekin Kocaoğlu, M. Arslan, M. Mert, Alper Köksal","doi":"10.5505/aot.2021.73549","DOIUrl":"https://doi.org/10.5505/aot.2021.73549","url":null,"abstract":"Aim: The aim of this study is to evaluate significance of Magnetic Resonance Imaging (MRI) characteristics and their effects on surgical margins, prognosis, oncological and functional outcomes of parosteal osteosarcoma in our clinic. Patients and method: Fifteen patients (4 male/11 female) who operated with the diagnosis of parosteal osteosarcoma in our clinic were retrospectively reviewed. The epidemiological data, biopsy method and delay in diagnosis are noted. The lesions maximum circumferential extension, intramedullary involvement and neurovascular extension in MRI sections were evaluated. The resection type (segmental articular/hemicortical) and surgical margins were noted. Functional and oncological results at last follow-up were assessed. Results: The mean age was 31.7 (17-71) years; mean follow-up was 50.1 (24-176) months. The most common site was distal femur. The closed biopsies were related with increased number of re-biopsies and misdiagnosis/improper interventions. (p<0.001,p=0.023) Intramedullary involvement percentage was related with maximum circumferential extension percentage (p=0.006) The intramedullary involvement ratio of ≤25% suggested no recurrence or metastasis. The mean MSTS score was 87.8% (range, 60-100%). The neurovascular involvement was related with metastatic disease, deep infections and complication related surgeries. (p=0.017, p=0.002,p=0.005) The most common resection type was segmental articular resection (9 patients). Hemicortical resections with biological reconstructions had the best MSTS scores. (p=0.002) The maximum circumferential extension percentage, intramedullary involvement percentage and neurovascular involvement showed lower MSTS scores. The 5-year overall survival was 92.3%, local recurrence-free survival was 86.2% and metastasis-free survival was 86.2%. Conclusion: The reliability of needle biopsy sampling is controversial in parosteal osteosarcomas. The lesions extent of intramedullary involvement, neurovascular bundle proximity and maximum periosteal circumferential extension on MRI should be considered when planning the surgery. The evaluation of maximum circumferential extension on MRI is crucial for the resection margins.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115940551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
U. Iltar, O. Salim, T. Ulaş, S. Berker Karaüzüm, C. Aydin, L. Undar
{"title":"Comparison the Clinical Features of Newly Diagnosed Multiple Myeloma Patients According to CD23 Expression Status","authors":"U. Iltar, O. Salim, T. Ulaş, S. Berker Karaüzüm, C. Aydin, L. Undar","doi":"10.5505/aot.2022.13008","DOIUrl":"https://doi.org/10.5505/aot.2022.13008","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"384 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115989781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lale Aydın Kaynar, Z. N. Özkurt, F. Can, Z. Yeğin, Özlem Güzel Tunçcan, M. Yağcı
{"title":"Standart Prophylactic Granulocyte Colony Stimulating Factor Usage As A Part Of Autologous Stem Cell Transplantati̇on Procedure","authors":"Lale Aydın Kaynar, Z. N. Özkurt, F. Can, Z. Yeğin, Özlem Güzel Tunçcan, M. Yağcı","doi":"10.5505/aot.2022.47113","DOIUrl":"https://doi.org/10.5505/aot.2022.47113","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116669488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sabin Göktaş Aydın, Burçin Çakan Demirel, A. Bilici, C. Yilmaz, A. Topçu, M. Aykan, S. Kahraman, M. Atçı, I. Akbıyık, Fahri Akgül, Ö. Ölmez, A. Aydin
{"title":"The Optimal Treatment Approaches and Prognostic Factors In Elderly Patients with Advanced Stage Biliary Tract Tumors","authors":"Sabin Göktaş Aydın, Burçin Çakan Demirel, A. Bilici, C. Yilmaz, A. Topçu, M. Aykan, S. Kahraman, M. Atçı, I. Akbıyık, Fahri Akgül, Ö. Ölmez, A. Aydin","doi":"10.5505/aot.2023.03708","DOIUrl":"https://doi.org/10.5505/aot.2023.03708","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"1121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116072966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aydan Avdan Aslan, Servet Erdemli, I. Erdogdu, Serap Gültekin, C. Uras, F. Tokat, A. Arıcan, Leyla Özer, Kemal Behzatoğlu, N. Meydan, F. Taşkın
{"title":"False-positive MRI Findings in Breast Cancer After Neoadjuvant Chemotherapy and Correlation Between Tumor Response Patterns and HER2 Status","authors":"Aydan Avdan Aslan, Servet Erdemli, I. Erdogdu, Serap Gültekin, C. Uras, F. Tokat, A. Arıcan, Leyla Özer, Kemal Behzatoğlu, N. Meydan, F. Taşkın","doi":"10.5505/aot.2023.60973","DOIUrl":"https://doi.org/10.5505/aot.2023.60973","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126752425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A 4-year-old boy has had cryptic membranous tonsillitis episode 5-6 times since last year and applied to our Ear Nose and Throat (ENT) clinic for the last 3 months of onset of odynophagia. Patient showed asymmetric hypertrophy of the left tonsil (grade 4) and the appearance of ulcerated surface was observed (Figure 1). In computerized tomography; (sections crossing oropharynx levels) it was interpreted as a mass that could be malignant in the soft tissue density of the contour of the left parapharyngeal lesion of approximately 41x31 mm. Tonsillectomy was performed with general anesthesia. Histopathologic and immunohistochemical findings were compatible with Burkitt's lymphoma (BL), CD20 (+) and Ki67 proliferation index were 90% positive (Figure 2). The patient was referred to the oncology clinic for chemotherapy.
{"title":"Asymmetric tonsil hypertrophy may be a sign of Burkitt’s lymphoma","authors":"S. Aydın, E. Boldaz","doi":"10.5505/AOT.2019.47550","DOIUrl":"https://doi.org/10.5505/AOT.2019.47550","url":null,"abstract":"A 4-year-old boy has had cryptic membranous tonsillitis episode 5-6 times since last year and applied to our Ear Nose and Throat (ENT) clinic for the last 3 months of onset of odynophagia. Patient showed asymmetric hypertrophy of the left tonsil (grade 4) and the appearance of ulcerated surface was observed (Figure 1). In computerized tomography; (sections crossing oropharynx levels) it was interpreted as a mass that could be malignant in the soft tissue density of the contour of the left parapharyngeal lesion of approximately 41x31 mm. Tonsillectomy was performed with general anesthesia. Histopathologic and immunohistochemical findings were compatible with Burkitt's lymphoma (BL), CD20 (+) and Ki67 proliferation index were 90% positive (Figure 2). The patient was referred to the oncology clinic for chemotherapy.","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124929690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retrospective analysis of patients diagnosed with multiple myeloma: A single center experience","authors":"M. Şimşek, P. Tarkun, A. Hacıhanefioğlu","doi":"10.5505/aot.2019.24582","DOIUrl":"https://doi.org/10.5505/aot.2019.24582","url":null,"abstract":"","PeriodicalId":435847,"journal":{"name":"Acta Oncologica Turcica","volume":"2012 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121751245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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