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Нарушение водно-электролитного обмена у пациентов с камнями мочеточников после контактной литотрипсии 接触石化病后输尿管结石患者缺水电解质紊乱
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2016-03-16 DOI: 10.20538/1682-0363-2012-2-40-43
Валентин Николаевич Павлов, А. М. Пушкарев, Алексеев Александр Владимирович, И. Г. Ракипов, Д. Р. Мусин, Адель Альбертович Измайлов
Urolithiasis is one of the most common urologic diseases, and 50% of patients with urolithiasis have ureteral stones. As with ureterolitiaze and in contact lithotripsy has been established development of glomerular and tubular dysfunction, which causes up to 9% of complications. Investigation of the parameters water-electrolyte metabolism carried out 52 patients with urolithiasis before and after contact ureterolitotripsi. Once installed KLT increase in glomerular filtration rate by 61% of the daily creatinine excretion a 43% urea 21%, sodium 28%, chlorides 55%, the concentration of ACTH 53% of cortisol 11%. In the urine increases the concentration of indicators of the glomerular and tubular dysfunction mikroalbumina 3 times, β2-microglobulin was 4,5 times, Ngala was 58%. The identified changes areapparently caused by intrarenal mechanisms only, because the major hormonal systems that regulate water and electrolyte metabolism, did not significantly change the parameters of its operation.
尿石症是最常见的泌尿系统疾病之一,50%的尿石症患者有输尿管结石。与输尿管结石术和接触式碎石术一样,已经确定肾小球和小管功能障碍的发展,这导致高达9%的并发症。对52例尿石症患者接触输尿管取石前后的水电解质代谢参数进行了调查。一旦安装KLT肾小球滤过率增加61%,每日肌酐排泄量增加43%,尿素21%,钠28%,氯化物55%,ACTH浓度增加53%,皮质醇增加11%。尿中肾小球和小管功能障碍指标微白蛋白浓度升高3倍,β2-微球蛋白升高4倍,β2-微球蛋白升高5倍,Ngala升高58%。已确定的变化显然仅由肾内机制引起,因为调节水和电解质代谢的主要激素系统并没有显着改变其运行参数。
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引用次数: 0
Antiinflammatory and antibacteriological properties of extracts from aboveground part of Delphinium elatum L. (ranunculaceae) 飞燕草地上部提取物的抗炎和抗菌作用
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2016-03-01 DOI: 10.20538/1682-0363-2012-3-58-61
T. N. Povetiyeva, Y. Nesterova, A. V. Krapivin, N. I. Suslov, L. V. Lavrentiyeva, S. S. Kravtsova, Yu. G. Nagornyak
В последнее время во всем мире отмечается повышенный интерес практической медицины к лекарственным препаратам, получаемым из растительного сырья. Среди природных фармакологически активных веществ алкалоиды являются основной группой, из которой современная медицина черпает наибольшее количество высокоэффективных лекарственных средств. Живокость высокая (Delphinium elatum L.) является малоизученным растением. Все его части содержат дитерпеновые алкалоиды, среди которых доминирующим является элатин [6]. В официнальной медицине препараты живокости применяются для лечения заболеваний центральной нервной системы [5]. Народная медицина издавна использовала живокость высокую для лечения заболеваний желудочно-кишечного тракта, в качестве ранозаживляющего, обезболивающего и противовоспалительного средства [2, 4]. Цель исследования — изучение противовоспалительных и антибактериальных свойств извлечений из надземной части живокости высокой.
最近,世界各地对从植物原料中提取的药物越来越感兴趣。在自然药理活性生物碱物质中,生物碱是现代医学从这些物质中获得最多有效药物的主要群体。它是一种鲜为人知的植物,被称为Delphinium elatum l。它的所有部分都含有二聚氰胺生物碱,其中最主要的是elatine(6)。在官方医学中,活动性药物被用于治疗中枢神经系统疾病(5)。长期以来,民间医学一直使用高活力来治疗胃肠道疾病,作为治疗伤口、止痛药和消炎药(2、4)。研究的目的是研究从高原生物中提取的消炎药和抗菌特性。
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引用次数: 0
How to protect oneself against medical errors 如何保护自己免受医疗事故的伤害
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2016-03-01 DOI: 10.20538/1682-0363-2012-1-122-127
F. F. Tetenev
The paper is devoted to the problem of medical errors in diagnosing. With the Siberian clinical school taken as an example, the theory of formation of clinical experience from the gradual accumulation of experience by the school founders to the active formation of clinical thinking through the use of the theory of diagnosing is presented.
这篇论文专门讨论诊断中的医疗差错问题。以西伯利亚临床学派为例,阐述了临床经验的形成理论,从学派创始人对经验的逐步积累到运用诊断理论主动形成临床思维。
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引用次数: 0
ИГРОВОЕ БИОУПРАВЛЕНИЕ ПРИ СИНДРОМЕ ДЕФИЦИТА ВНИМАНИЯ С ГИПЕРАКТИВНОСТЬЮ 注意力缺陷多动症游戏生物控制
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2016-01-15 DOI: 10.20538/1682-0363-2013-2-166-174
И. А. Столлер, Е. Г. Веревкин, М. В. Сухоленцева
We continue the study of students with attention deficit hyperactivity disorder when using betastimulating game neurofeedback. The dynamics of segmental characteristics of the alpha rhythm and θ/β ratio for different groups of successful training. Evaluate the effectiveness of training in terms of the number of ADHD symptoms (at the beginning and end of the training).
我们继续使用贝塔刺激游戏的神经反馈对患有注意缺陷多动障碍的学生进行研究。不同训练成功组的α节奏和θ/β比的节段特征动态。根据ADHD症状的数量(在训练开始和结束时)评估训练的有效性。
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引用次数: 0
NEUROFEEDBACK AND EMG TRAINING COMBINING EFFICIENCY STUDY IN 6–9 YEARS OLD ADHD CHILDREN 6-9岁adhd儿童神经反馈与肌电训练相结合的疗效研究
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2016-01-01 DOI: 10.20538/1682-0363-2013-2-161-165
Ye. А. Sapina
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引用次数: 0
Ассоциация генов подверженности к алкоголизму, шизофрении и болезни Альцгеймера с психодиагностическими признаками в популяции русских 酗酒、精神分裂症和阿尔茨海默氏症基因协会在俄罗斯人口中具有心理不可知论特征。
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2016-01-01 DOI: 10.20538/1682-0363-2016-5-83-96
Марусин Андрей Викторович, Корнетов Александр Николаевич, Сваровская Мария Геннадьевна, Вагайцева Ксения Валерьевна, Павленюк Екатерина Степановна, Степанов Вадим Анатольевич
The purpose of this paper is to identify genetic factors connected with personal features using the panel of 12 polymorphic markers associated with the risk of developing dementia in patients with Alzheimer’s disease, schizophrenia and alcoholism. Materials and methods. The correlation among quantitative traits of personality, temperament and character determined with Cattell’s (the Sixteen personality factor questionnaire (16PF)), Leonhard-Schmieschek’s, Spielberger-Khanin’s, and Eysenck’s (IQ) tests were analyzed with polymorphic variants of 12 genes involved in the development of severe mental disorders such as alcoholism, schizophrenia and Alzheimer’s disease. DNA samples of 150 students were genotyped using PCR-RPLF method. The data were processed by nonparametric statistical methods. Results. Interallelic nonrandom associations in paired combinations of GABRA2-PICALM, PICALMADCY3, CLU-CBX7 and CLU-ADCY3 polymorphisms were detected. This may indicate the adaptive selection influencing the maintenance of behavioral homeostasis in population. A number of statistically significant associations of genetic variation were found: CLU with perfectionism(Q3) of 16PF and the exaltation of the Leonhard’s tests, PICALM with tension (Q4) of 16PF and the imbalance of Leonhard’s tests, DISC1 with vigilance(L) of 16PF, and exaltation, cyclothymia of Leonhard’s tests, ZNF804A with imbalance by Leonhard’s test, SLC6A4 with reasoning(B) of 16PF test, ADCY3 with self-reliance(Q2) and extraversion(F2) of 16PF test, MIR9-2 emotional stability(C), liveliness(F), social boldness(H), extraversion(F2) of 16PF, and dysthymia, hyperthymia of Leonhard’s tests, with the personal anxiety of Spielberger-Khanin’s test, CBX7 with vigilance(L), warmth(A) of 16PF test, SLC6A3 with IQ. Conclusion. These findings support the idea of overlapping genetic component in common mental and neurological disorders and variability of human cognitive and personality traits.
本文的目的是利用与阿尔茨海默病、精神分裂症和酗酒患者发生痴呆风险相关的12个多态标记来确定与个人特征相关的遗传因素。材料和方法。采用与酗酒、精神分裂症和阿尔茨海默病等严重精神障碍相关的12个基因的多态性变异,分析了由卡特尔(16PF)、Leonhard-Schmieschek、Spielberger-Khanin和Eysenck (IQ)测试确定的人格、气质和性格数量性状之间的相关性。采用PCR-RPLF方法对150名学生的DNA样本进行基因分型。数据采用非参数统计方法处理。结果。GABRA2-PICALM、PICALMADCY3、ccl - cbx7和ccl - adcy3多态性配对组合中检测到等位基因间非随机关联。这可能表明适应性选择影响了种群行为稳态的维持。研究发现了一些与遗传变异有统计学意义的关联:CLU具有16PF的完美主义(Q3)和莱昂哈德测试的提高,PICALM具有16PF的紧张性(Q4)和莱昂哈德测试的不平衡性,DISC1具有16PF的警惕性(L)和提高,莱昂哈德测试的循环性心境障碍,ZNF804A具有莱昂哈德测试的不平衡性,SLC6A4具有16PF测试的推理性(B), ADCY3具有16PF测试的自立性(Q2)和外向性(F2), MIR9-2情绪稳定性(C),活泼(F),社交大胆(H),外向性(F2),心境障碍。Leonhard’s测试中的亢进与Spielberger-Khanin’s测试中的个人焦虑、CBX7与16PF测试中的警惕性(L)、温暖性(A)、SLC6A3与智商。结论。这些发现支持了在常见的精神和神经疾病以及人类认知和人格特征的可变性中重叠遗传成分的观点。
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引用次数: 8
УПРАВЛЕНИЕ ИННОВАЦИОННОЙ ДЕЯТЕЛЬНОСТЬЮ В ЗДРАВООХРАНЕНИИ НА РЕГИОНАЛЬНОМ УРОВНЕ 区域一级医疗创新活动管理
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2015-12-30 DOI: 10.20538/1682-0363-2014-5-184-194
Елена Геннадьевна Тоцкая, Михаил Анатольевич Садовой
The paper reviews topical issues of organization and management of innovative activity in the regional health care system. Objective . Development and scientific substantiation of a conceptual model of managing innovation in the regional health care system, introduction of institutional mechanisms for its implementation, and evaluation of their efficacy in using diagnosis and treatment technologies. Objectives of the study included reviewing the organization status and problems hampering the development, identification of prospects, and justification for appropriate changes in innovation in healthcare system and medical science at the regional level. Material and methods . To conduct a comprehensive assessment of the status and meet challenges of innovation promotion, a methodology for social-hygienic research was worked out including bibliographic and analytical methods, situational analysis, sociological and economic methods, expert assessment, methods for quality management system audit in accordance with ISO 19011:2002, IDEFO function modeling (RD IDEF0-2000), and organizational modeling. The study was based on the analysis of foreign and domestic literature, statistics, methods for managerial modeling, as well as management experience (including innovative methodological approaches) gained by Novosibirsk Research Institute of Traumatology and Orthopedics named after Ya.L. Tsivyan which meets the requirements for a platform for research and innovative product reproduction, including research, clinical, organizational, and managerial aspects. Other facilities were considered in conjunction with the leading innovative platform. Results . The paper presents a scientifically based model of innovative medical environment with its elements as subjects, each with a set of functions. Conceptual model for management includes structuring (resource, processes, and quality management; application of international standards) and strategic management mechanisms, provides a systematic approach to management, and ensures efficient operation of medical institutions and public access to innovative medical diagnostic technologies. The advantage of innovative products and technologies using within the doctrine of innovative management is that they provide a comprehensive approach to the diagnosis and treatment of patients. The introducted managing innovation technologies allow to improve organizational performance of healthcare institutions and to achieve significant medical and social effects: high level of diagnosis and treatment, improved access and quality of care what promotes the public health. Conclusion . Formation of regional innovation medical environment with advanced innovation infrastructure, interaction of its elements through an effective system of coordination and control is a prerequisite and basis for more mature and system-level structure – an industry innovative cluster. Active development of innovation in health care based on cooperation amo
本文回顾了区域卫生保健系统中创新活动的组织和管理的主题问题。目标。发展和科学证实区域卫生保健系统管理创新的概念模型,引入其实施的体制机制,并评估其在使用诊断和治疗技术方面的功效。本研究的目的包括检讨组织现状和阻碍发展的问题,识别前景,以及在区域层面上适当改变卫生保健系统和医学科学创新的理由。材料和方法。为全面评价创新促进的现状和面临的挑战,建立了社会卫生研究方法,包括文献分析法、情景分析法、社会学和经济学方法、专家评价方法、ISO 19011:2002质量管理体系审核方法、IDEFO功能模型(RD IDEF0-2000)和组织模型。本研究基于对国内外文献、统计、管理建模方法的分析,以及以Ya.L命名的新西伯利亚创伤骨科研究所的管理经验(包括创新的方法论方法)。Tsivyan满足研究和创新产品复制平台的要求,包括研究,临床,组织和管理方面。其他设施与领先的创新平台一起被考虑。结果。本文以创新医疗环境的要素为主体,提出了一个基于科学的创新医疗环境模型,每个要素都有一套功能。管理的概念模型包括结构(资源、过程和质量管理);国际标准和战略管理机制的应用,提供了一种系统的管理方法,并确保医疗机构的有效运作和公众获得创新的医疗诊断技术。创新产品和技术在创新管理理论中的优势在于,它们为患者的诊断和治疗提供了一种全面的方法。引进的管理创新技术可以改善医疗保健机构的组织绩效,并取得显著的医疗和社会效果:高水平的诊断和治疗,改善了获取和护理质量,从而促进了公众健康。结论。形成具有先进创新基础设施的区域创新医疗环境,其要素通过有效的协调控制体系相互作用,是形成更加成熟的系统级结构——产业创新集群的前提和基础。在不同创新行为者之间的合作和机构间协作的基础上积极发展卫生保健领域的创新,为研究商业化领域提供专业人员,实现创新技术向实体经济的转移,并通过实施技术和科学研究项目,使其能够融入全球创新环境。
{"title":"УПРАВЛЕНИЕ ИННОВАЦИОННОЙ ДЕЯТЕЛЬНОСТЬЮ В ЗДРАВООХРАНЕНИИ НА РЕГИОНАЛЬНОМ УРОВНЕ","authors":"Елена Геннадьевна Тоцкая, Михаил Анатольевич Садовой","doi":"10.20538/1682-0363-2014-5-184-194","DOIUrl":"https://doi.org/10.20538/1682-0363-2014-5-184-194","url":null,"abstract":"The paper reviews topical issues of organization and management of innovative activity in the regional health care system. Objective . Development and scientific substantiation of a conceptual model of managing innovation in the regional health care system, introduction of institutional mechanisms for its implementation, and evaluation of their efficacy in using diagnosis and treatment technologies. Objectives of the study included reviewing the organization status and problems hampering the development, identification of prospects, and justification for appropriate changes in innovation in healthcare system and medical science at the regional level. Material and methods . To conduct a comprehensive assessment of the status and meet challenges of innovation promotion, a methodology for social-hygienic research was worked out including bibliographic and analytical methods, situational analysis, sociological and economic methods, expert assessment, methods for quality management system audit in accordance with ISO 19011:2002, IDEFO function modeling (RD IDEF0-2000), and organizational modeling. The study was based on the analysis of foreign and domestic literature, statistics, methods for managerial modeling, as well as management experience (including innovative methodological approaches) gained by Novosibirsk Research Institute of Traumatology and Orthopedics named after Ya.L. Tsivyan which meets the requirements for a platform for research and innovative product reproduction, including research, clinical, organizational, and managerial aspects. Other facilities were considered in conjunction with the leading innovative platform. Results . The paper presents a scientifically based model of innovative medical environment with its elements as subjects, each with a set of functions. Conceptual model for management includes structuring (resource, processes, and quality management; application of international standards) and strategic management mechanisms, provides a systematic approach to management, and ensures efficient operation of medical institutions and public access to innovative medical diagnostic technologies. The advantage of innovative products and technologies using within the doctrine of innovative management is that they provide a comprehensive approach to the diagnosis and treatment of patients. The introducted managing innovation technologies allow to improve organizational performance of healthcare institutions and to achieve significant medical and social effects: high level of diagnosis and treatment, improved access and quality of care what promotes the public health. Conclusion . Formation of regional innovation medical environment with advanced innovation infrastructure, interaction of its elements through an effective system of coordination and control is a prerequisite and basis for more mature and system-level structure – an industry innovative cluster. Active development of innovation in health care based on cooperation amo","PeriodicalId":43691,"journal":{"name":"Byulleten Sibirskoy Meditsiny","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2015-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67685099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
ОСОБЕННОСТИ ОСНОВНЫХ ПОКАЗАТЕЛЕЙ ФИЗИЧЕСКОГО РАЗВИТИЯ ПОДРОСТКОВ В ТОМСКОЙ ОБЛАСТИ 托木斯克地区青少年身体发育的特征
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2015-12-28 DOI: 10.20538/1682-0363-2015-6-40-47
I. A. Deyev, I. L. Kolomeyets, Ye. M. Kamaltynova, Y. S. Kulikov, A. N. Levko, O. S. Fyodorova, Kristina V. Kulikova, V. I. Yurkova
Objective. To study the physical growth and development of adolescents (aged 13–16 years) living in the Tomsk region.  Material and Methods. This study is a framework (№299 from 18.07.2011) of the Department of Health Care of Tomsk region, we analyzed the results of medical examinations of adolescents (n = 7120, average age 13.98 ± 0.04, 49.87% – boys). Measurements of height and weight, the circumference of the chest and head (data rounded to 0.1 kg and 0.1 cm, respectively) are taken. The body mass index (BMI) is calculated as the ratio of weight (kg) / height2 (m2). Statistical analysis was performed using the software package Statistica for Windows 10.0 and the software StatCalc 6.0. Results. Average height of adolescents is (163.10 ± 0.09) cm. On Average boys are taller than girls ((165.34 ± 0.15) cm and (160.87 ± 0.11) cm, p < 0.001). The body weight is (53.99 ± 0.13) kg (boys – (55.28 ± 0.20) kg, girls – (52.72 ± 0.17) kg, p < 0.001). Boys chest circumference is (79.26 ± 0.30) cm, girls is (79.99 ± 0.13) cm, head circumference are (55.43 ± 0.07) cm and (54.77 ± 0.04) cm, respectively (p < 0.01). The results show difference between Tomsk boys and rest of the Russia Federation. The average BMI is (20.20 ± 0.04) kg/m2 (girls – (20.32 ± 0.07), boys – (20.08 ± 0.06) kg/m2). The urban lifestyle in Tomsk Region leads to boys obesity. Conclusion. The study revealed the regional physical growth and development characteristics. Anthropometric data in Tomsk region adolescents are higher than the same data in RF.
目标。研究生活在托木斯克地区的青少年(13-16岁)的身体生长和发育。材料和方法。该研究是托木斯克州卫生保健部门的框架(№299,2011年7月18日),我们分析了青少年的医学检查结果(n = 7120,平均年龄13.98±0.04,49.87% -男孩)。测量身高、体重、胸围和头围(数据分别四舍五入至0.1公斤和0.1厘米)。体重指数(BMI)是体重(kg) /身高(m2)的比值。采用Statistica for Windows 10.0软件包和StatCalc 6.0软件进行统计分析。结果。青少年平均身高为(163.10±0.09)cm。男生平均身高高于女生((165.34±0.15)cm和(160.87±0.11)cm, p < 0.001)。体重为(53.99±0.13)kg(男生为(55.28±0.20)kg,女生为(52.72±0.17)kg, p < 0.001)。男生胸围为(79.26±0.30)cm,女生胸围为(79.99±0.13)cm,头围分别为(55.43±0.07)cm和(54.77±0.04)cm (p < 0.01)。结果显示了托木斯克男孩和俄罗斯联邦其他地区的差异。平均BMI为(20.20±0.04)kg/m2,其中女生为(20.32±0.07)kg/m2,男生为(20.08±0.06)kg/m2。托木斯克州的城市生活方式导致男孩肥胖。结论。研究揭示了区域物理生长发育特征。托木斯克地区青少年的人体测量数据高于RF地区的相同数据。
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引用次数: 1
Послеродовая депрессия - центральная проблема охраны психического здоровья раннего материнства 产后抑郁症是保护早产儿心理健康的核心问题。
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2015-12-28 DOI: 10.20538/1682-0363-2015-6-5-24
N. A. Kornetov
Perinatal mental health of the mother occupies a central position in healthcare, the same as caring for a newborn baby. Maternal depression is the lead pathology of postpartum period. Despite the high prevalence and importance to the overall development of children, most cases of depression are unappreciated, unrecognized and untreated. Inattention to issues which are related to physical and mental health of women, leads to severe negative social and economic consequences for society. Statistical comparison of the total number of pregnant women, the number of births in the United States in 2007, excluding cases of fetal loss, including still-births and miscarriages with similar Russian data allowed to calculate the approximate prevalence of postpartum depression in the same period. Presumable probability of postpartum depression is 15% in different regions of the world, and the diagnostic criteria of DSM-IV for postpartum depression are representative for comparison. Considering these assumptions, according to 2007 each year about 260,000 out of 1 mln. 600,000 of Russian women in childbirth may suffer from post-natal depression. The results have a probabilistic character. For the mothers the consequences of unrecognized and untreated depression after childbirth are the most frequent. It should be seen as a depressive episode or recurrent depressive disorder which has a singular coloring due to the appearance in the peak period of reproductive age of women. Postpartum depression may increase the possibility of occurrence of relapse of a depressive disorder as well as the transition to a state of chronic depression. Alcoholism or drug use is a common complication of depression; the risk of suicide increases, especially during the time of reducing the severity of the most severe symptoms of depression, though it is below the prevalence of suicide among the population. Particular attention should be paid to such symptoms as instability in mood and irritability as during the postpartum depression and in its residual period. They can cause child abuse. This paper also presents current data on the epidemiology, etiology, risk factors for postpartum depression, its clinical manifestations, the influence of untreated maternal depression on child development, therapy and educational modules to spread multidisciplinary and inter-agency approach in perinatal mental health problems.
母亲的围产期心理健康与照顾新生儿一样,在医疗保健中占据中心地位。产妇抑郁是产后的主要病理。尽管抑郁症的患病率很高,对儿童的整体发展也很重要,但大多数抑郁症病例都没有得到重视、认识和治疗。不重视与妇女身心健康有关的问题,会给社会造成严重的负面社会和经济后果。统计比较2007年美国孕妇总人数,出生人数,不包括胎儿丢失的情况,包括死产和流产,与俄罗斯类似的数据可以计算出同期产后抑郁症的大致患病率。产后抑郁症在世界不同地区的推定概率为15%,DSM-IV对产后抑郁症的诊断标准具有代表性,便于比较。考虑到这些假设,根据2007年每年约有26万人死亡。60万俄罗斯产妇可能患有产后抑郁症。结果具有概率特征。对于母亲来说,分娩后未被识别和未经治疗的抑郁症是最常见的后果。它应被视为一种抑郁发作或复发性抑郁症,由于出现在女性生育年龄的高峰期,其颜色单一。产后抑郁可能增加抑郁症复发的可能性,也可能增加向慢性抑郁状态过渡的可能性。酗酒或吸毒是抑郁症的常见并发症;自杀的风险增加了,特别是在最严重的抑郁症症状的严重程度减轻期间,尽管它低于人口中自杀的流行率。在产后抑郁期间及其残留期,应特别注意情绪不稳定和烦躁等症状。它们会导致虐待儿童。本文还介绍了产后抑郁症的流行病学、病因、危险因素、临床表现、未经治疗的产妇抑郁症对儿童发育的影响、治疗和教育模块等方面的最新数据,以推广围产期心理健康问题的多学科和机构间方法。
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引用次数: 4
ФАРМАКОЭПИДЕМИОЛОГИЧЕСКИЙ И ФАРМАКОЭКОНОМИЧЕСКИЙ АНАЛИЗ АНТИБАКТЕРИАЛЬНОЙ ТЕРАПИИ ЭНДОМЕТРИТА НА ГОСПИТАЛЬНОМ ЭТАПЕ 医院阶段药物流行病学和药理学分析
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2015-12-28 DOI: 10.20538/1682-0363-2015-6-81-86
L. Y. Chernikova, M. Belousov
Pharmacoepidemiological and pharmacoeconomical analysis of endometrit drug therapy at special treatment-and-prophylactic institutions of the city of Tomsk. Estimate the intensity of the appointment of antibacterial drugs endometrit therapy using the methodology of the WHO ATC/DDD, calculated indicators of the intensity of the consumption of drugs in the course of treatment per patient. It was shown that 70% of the established daily dose had to beta-lactam antibiotics and macrolide. For the most common options for antibiotic therapy established nosology of the indicators of clinical efficacy. The calculation of the cost of the schemes of antibiotic therapy, which showed that the cost of treatment is maximal during therapy with ceftriaxone + clarithromycin (4902 RUR); further descending follow: amoxicillin / clavulanic acid + roxithromycin (4658 RUR); benzylpenicillin and gentamicin (4231 RUR). Economic efficiency of antibacterial treatments endometritis a “cost – effectiveness”. The cost of the patient, achieved remission, made during therapy with amoxicillin/clavulanic acid and roxithromycin (5416 RUR), During therapy with ceftriaxone and clarithromycin (6052 RUR), the treatment of benzylpenicillin and gentamicin (14420 RUR). Pharmacoeconomic evaluation results showed that the least acceptable scheme of antibacterial therapy of endometrit in the hospital is the combination of benzyl penicillin and gentamicin. Тhe antibiotic therapy for endometrit may be recommended by a combination of amoxicillin / clavulanic acid and roxithromycin and clarithromycin and ceftriaxone, for which there was no statistically significant differences in clinical efficacy and cost of antibiotic therapy.
托木斯克市特殊治疗和预防机构子宫内膜药物治疗的药物流行病学和药物经济学分析。使用世卫组织ATC/DDD的方法估计使用抗菌药物子宫内膜治疗的强度,计算每位患者治疗过程中药物消耗强度的指标。研究表明,70%的既定日剂量必须使用β -内酰胺类抗生素和大环内酯类药物。对于最常见的抗生素治疗方案建立了分类学的临床疗效指标。各抗生素治疗方案的费用计算结果表明,头孢曲松+克拉霉素治疗方案的治疗费用最大(4902 RUR);进一步降序依次为:阿莫西林/克拉维酸+罗红霉素(RUR 4658);青霉素和庆大霉素(4231 RUR)。经济高效的抗菌治疗子宫内膜炎具有“性价比”。患者在阿莫西林/克拉维酸和罗红霉素治疗期间获得缓解的费用(5416 RUR),在头孢曲松和克拉红霉素治疗期间(6052 RUR),在青霉素和庆大霉素治疗期间(14420 RUR)。药物经济学评价结果显示,该院最难以接受的子宫内膜抗菌治疗方案是青霉素与庆大霉素联用。Тhe子宫内膜抗生素治疗可推荐阿莫西林/克拉维酸与罗红霉素、克拉霉素与头孢曲松联合使用,两种抗生素治疗的临床疗效和费用差异无统计学意义。
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Byulleten Sibirskoy Meditsiny
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