Pub Date : 2022-10-01DOI: 10.4103/injms.injms_50_22
Safia Bano, Zomer Sardar, M. Ahmar, Sumayyah Liaquat, B. Shafiq, A. Numan
Context: Guillain-Barré syndrome (GBS) is an acute inflammatory neuropathy and has several electrophysiological subtypes and clinical variants. Treatment is mainly supportive and immunotherapy is given to shorten the disease course. Aims: The aim of this study was to define the outcome of GBS with plasmapheresis and to determine its clinical spectrum. Materials and Methods: The prospective study was done at Mayo Hospital, Lahore, for 1 year from November 2020 to November 2021. The diagnosis of GBS was made on Brighton criteria for GBS. The outcome of therapy was assessed at 3 and 6 months, using the Medical Research Council Scale and Hughes Functional Grading Scale (HFGS). Results: A total of 50 patients were enrolled in the study. Twenty-seven (54%) were males and 23 (46%) were females. Seventeen (34%) had acute motor axonal neuropathy, 16 (32%) had acute motor and sensory axonal neuropathy, 15 (30%) had acute inflammatory demyelinating polyradiculoneuropathy, and 2 (4%) had Miller-Fisher syndrome. Plasmapheresis was done in all patients. HFGS score was assessed at discharge, at 3 months, and after 6 months of illness onset. The improvement in mean HFGS score was 2.79 ± 0.41 at 3 months and 1.94 ± 0.25 at 6 months of symptoms onset from the mean score of 3.46 ± 0.93 at the time of discharge from the hospital. Conclusion: Excellent outcome was observed after plasmapheresis. Majority of participants were able to walk without support at the 6-month follow-up. Plasmapheresis should be initiated early in the management of GBS where intravenous immunoglobulins are costly.
{"title":"Clinical spectrum and outcome of guillain-barré syndrome with plasmapheresis","authors":"Safia Bano, Zomer Sardar, M. Ahmar, Sumayyah Liaquat, B. Shafiq, A. Numan","doi":"10.4103/injms.injms_50_22","DOIUrl":"https://doi.org/10.4103/injms.injms_50_22","url":null,"abstract":"Context: Guillain-Barré syndrome (GBS) is an acute inflammatory neuropathy and has several electrophysiological subtypes and clinical variants. Treatment is mainly supportive and immunotherapy is given to shorten the disease course. Aims: The aim of this study was to define the outcome of GBS with plasmapheresis and to determine its clinical spectrum. Materials and Methods: The prospective study was done at Mayo Hospital, Lahore, for 1 year from November 2020 to November 2021. The diagnosis of GBS was made on Brighton criteria for GBS. The outcome of therapy was assessed at 3 and 6 months, using the Medical Research Council Scale and Hughes Functional Grading Scale (HFGS). Results: A total of 50 patients were enrolled in the study. Twenty-seven (54%) were males and 23 (46%) were females. Seventeen (34%) had acute motor axonal neuropathy, 16 (32%) had acute motor and sensory axonal neuropathy, 15 (30%) had acute inflammatory demyelinating polyradiculoneuropathy, and 2 (4%) had Miller-Fisher syndrome. Plasmapheresis was done in all patients. HFGS score was assessed at discharge, at 3 months, and after 6 months of illness onset. The improvement in mean HFGS score was 2.79 ± 0.41 at 3 months and 1.94 ± 0.25 at 6 months of symptoms onset from the mean score of 3.46 ± 0.93 at the time of discharge from the hospital. Conclusion: Excellent outcome was observed after plasmapheresis. Majority of participants were able to walk without support at the 6-month follow-up. Plasmapheresis should be initiated early in the management of GBS where intravenous immunoglobulins are costly.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48040260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/injms.injms_23_22
M. Abdulla
A 73-year-old male was admitted with hemoptysis for 2 months. He was diagnosed to have sputum-positive pulmonary tuberculosis 4 years back and was treated with antitubercular drugs for 6 months. Contrast-enhanced computed tomography (CT) of the thorax at that time revealed a cavitary lesion with surrounding consolidation in the right lower lobe of the lung. Contrast-enhanced CT of the chest during present admission showed a mass lesion in the lower lobe of the right lung, which was diagnosed as large cell neuroendocrine carcinoma of the lung on histopathological examination. We describe a patient who developed large cell neuroendocrine carcinoma of the lung in a posttuberculosis cavity which, to our knowledge, is the first such report.
{"title":"Large cell neuroendocrine carcinoma of the lung in posttuberculosis cavity","authors":"M. Abdulla","doi":"10.4103/injms.injms_23_22","DOIUrl":"https://doi.org/10.4103/injms.injms_23_22","url":null,"abstract":"A 73-year-old male was admitted with hemoptysis for 2 months. He was diagnosed to have sputum-positive pulmonary tuberculosis 4 years back and was treated with antitubercular drugs for 6 months. Contrast-enhanced computed tomography (CT) of the thorax at that time revealed a cavitary lesion with surrounding consolidation in the right lower lobe of the lung. Contrast-enhanced CT of the chest during present admission showed a mass lesion in the lower lobe of the right lung, which was diagnosed as large cell neuroendocrine carcinoma of the lung on histopathological examination. We describe a patient who developed large cell neuroendocrine carcinoma of the lung in a posttuberculosis cavity which, to our knowledge, is the first such report.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47479038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/injms.injms_131_22
A. Prakash, Ramesh Aggarwal
{"title":"Is the fight against COVID-19 falling prey to vaccine hesitancy?","authors":"A. Prakash, Ramesh Aggarwal","doi":"10.4103/injms.injms_131_22","DOIUrl":"https://doi.org/10.4103/injms.injms_131_22","url":null,"abstract":"","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46473261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/injms.injms_42_22
Y. Mouzari, I. Fiqhi, Belfaiza Soukaina, T. Abdellaoui, M. Allaoui, K. Reda, A. Oubaaz
Paraneoplastic optic neuropathy is a relatively rare ocular manifestation. We report the case of a patient with bilateral papilledema revealing a pulmonary squamous cell carcinoma. Paraneoplastic neuropathy is linked to an immune reaction by the presence of autoantibodies against collapsin responsive mediator protein 5 . Diagnosis is based on the determination of these autoantibodies and the search for occult cancer by PET scan.Treatment is often based on corticosteroid therapy and sometimes immunosuppressive treatment is necessary in the case of corticosteroid unresponsiveness.
{"title":"A paraneoplastic optic neuropathy revealing a pulmonary epidermal carcinoma","authors":"Y. Mouzari, I. Fiqhi, Belfaiza Soukaina, T. Abdellaoui, M. Allaoui, K. Reda, A. Oubaaz","doi":"10.4103/injms.injms_42_22","DOIUrl":"https://doi.org/10.4103/injms.injms_42_22","url":null,"abstract":"Paraneoplastic optic neuropathy is a relatively rare ocular manifestation. We report the case of a patient with bilateral papilledema revealing a pulmonary squamous cell carcinoma. Paraneoplastic neuropathy is linked to an immune reaction by the presence of autoantibodies against collapsin responsive mediator protein 5 . Diagnosis is based on the determination of these autoantibodies and the search for occult cancer by PET scan.Treatment is often based on corticosteroid therapy and sometimes immunosuppressive treatment is necessary in the case of corticosteroid unresponsiveness.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45001016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/injms.injms_95_22
Ellora Barman, B. Barman, A. Nune, A. Nongpiur
Background: Reference management software (RMS) enable researchers to organize and manage large number of references that are typically identified during the publication of research articles. Aims and Objectives: The purpose of our study was to determine the extent to which faculties from allopathy, homeopathy, and Ayurveda use RMS for their academic pursuits and to identify which methods are used most frequently. Methods: The survey was circulated among the faculties of three different disciplines of the health-care system to collect respondent demographic details and questionnaire responses. Data distribution and variable type were used to perform descriptive analysis. Results: The data from 114/150 respondents were analyzed. Of the 114 faculties who responded to our survey, 72 (63%) reported using RMS to publish their articles. Knowledge of how to use RMS software is common in allopathic faculties (40%), followed by homeopathy (14%) and Ayurveda (9%). Zotero (41%) is the most popular RMS software among users, followed by Mendeley (31%) and Endnote (12%). Conclusion: Despite being underreported, RMS software is frequently used for the needs of authors from various disciplines in the health-care system.
{"title":"Use of reference management software among Allopathy, Ayurveda, and Homeopathy practices","authors":"Ellora Barman, B. Barman, A. Nune, A. Nongpiur","doi":"10.4103/injms.injms_95_22","DOIUrl":"https://doi.org/10.4103/injms.injms_95_22","url":null,"abstract":"Background: Reference management software (RMS) enable researchers to organize and manage large number of references that are typically identified during the publication of research articles. Aims and Objectives: The purpose of our study was to determine the extent to which faculties from allopathy, homeopathy, and Ayurveda use RMS for their academic pursuits and to identify which methods are used most frequently. Methods: The survey was circulated among the faculties of three different disciplines of the health-care system to collect respondent demographic details and questionnaire responses. Data distribution and variable type were used to perform descriptive analysis. Results: The data from 114/150 respondents were analyzed. Of the 114 faculties who responded to our survey, 72 (63%) reported using RMS to publish their articles. Knowledge of how to use RMS software is common in allopathic faculties (40%), followed by homeopathy (14%) and Ayurveda (9%). Zotero (41%) is the most popular RMS software among users, followed by Mendeley (31%) and Endnote (12%). Conclusion: Despite being underreported, RMS software is frequently used for the needs of authors from various disciplines in the health-care system.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44103884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/injms.injms_87_22
M. Abdulla
{"title":"Cutaneous leukocytoclastic vasculitis after ChAdOx1 nCoV-19 vaccine","authors":"M. Abdulla","doi":"10.4103/injms.injms_87_22","DOIUrl":"https://doi.org/10.4103/injms.injms_87_22","url":null,"abstract":"","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43437473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/injms.injms_62_22
Belfaiza Soukaina, Abdellaoui Taoufiq, Fiqhi Issam, Mouzari Yassine, R. Karim, Oubaaz Bar
Ocular syphilis is a disease known as a great simulator.It can affect the structures of the eye. It often manifests by an anterior uveitis. Posterior segment involvement is very rare and it is exceptionally complicated by exudative retinal detachment. We report the case of a patient with bilateral bullous retinal detachment in the context of ocular syphilis with a good evolution after treatment by penicillin G and corticotherapy.
{"title":"Exudative retinal detachment: An unusual ocular manifestation of syphilis","authors":"Belfaiza Soukaina, Abdellaoui Taoufiq, Fiqhi Issam, Mouzari Yassine, R. Karim, Oubaaz Bar","doi":"10.4103/injms.injms_62_22","DOIUrl":"https://doi.org/10.4103/injms.injms_62_22","url":null,"abstract":"Ocular syphilis is a disease known as a great simulator.It can affect the structures of the eye. It often manifests by an anterior uveitis. Posterior segment involvement is very rare and it is exceptionally complicated by exudative retinal detachment. We report the case of a patient with bilateral bullous retinal detachment in the context of ocular syphilis with a good evolution after treatment by penicillin G and corticotherapy.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48243988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/injms.injms_35_22
Ashutosh Garg, Khyati Thapliyal, Vivek Singh
Naltrexone, an opioid receptor (OR) antagonist, at its standard doses, is a United States Federal Drug Administration-approved drug for opioid and alcohol use disorders. However, with the discovery of nonneuropsychiatric effects of OR signaling with low-dose naltrexone, it has found novel applications in inflammatory, malignant, insulin sensitivity-related, and chronic pain conditions. Lower doses also ameliorate its adverse effects. Its off-label use in the abovementioned situations has proven to be cost-effective against costly immunomodulating and antineoplastic drugs. Its lower cost and miniscule margin of interest have precluded in-depth analysis by the pharmaceutical industry. So far, only animal studies, cell culture studies, and case reports have been conducted, some of which exhibit promising benefits. There is a dearth of much-needed quality trials.
{"title":"Naltrexone beyond psychiatric domain","authors":"Ashutosh Garg, Khyati Thapliyal, Vivek Singh","doi":"10.4103/injms.injms_35_22","DOIUrl":"https://doi.org/10.4103/injms.injms_35_22","url":null,"abstract":"Naltrexone, an opioid receptor (OR) antagonist, at its standard doses, is a United States Federal Drug Administration-approved drug for opioid and alcohol use disorders. However, with the discovery of nonneuropsychiatric effects of OR signaling with low-dose naltrexone, it has found novel applications in inflammatory, malignant, insulin sensitivity-related, and chronic pain conditions. Lower doses also ameliorate its adverse effects. Its off-label use in the abovementioned situations has proven to be cost-effective against costly immunomodulating and antineoplastic drugs. Its lower cost and miniscule margin of interest have precluded in-depth analysis by the pharmaceutical industry. So far, only animal studies, cell culture studies, and case reports have been conducted, some of which exhibit promising benefits. There is a dearth of much-needed quality trials.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43397396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/injms.injms_72_22
Tariq Janjua, L. Moscote-Salazar, W. Florez-Perdomo
{"title":"The posterior fossa intracranial pressure monitoring in neurocritical care: It is time to evaluate objectively in forbidden territories","authors":"Tariq Janjua, L. Moscote-Salazar, W. Florez-Perdomo","doi":"10.4103/injms.injms_72_22","DOIUrl":"https://doi.org/10.4103/injms.injms_72_22","url":null,"abstract":"","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42468207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/injms.injms_71_22
M. Abdulla
{"title":"Acute hemorrhagic leukoencephalitis in COVID-19 infection","authors":"M. Abdulla","doi":"10.4103/injms.injms_71_22","DOIUrl":"https://doi.org/10.4103/injms.injms_71_22","url":null,"abstract":"","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46060221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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