Pub Date : 2022-07-01DOI: 10.4103/injms.injms_137_21
A. Adeniran, O. Jimoh, O.Z Omoyiola, Adetokunbo Vaughan
Benign metastasizing leiomyoma (BML) is an uncommon disorder characterized by occurrence of benign smooth muscle tumor with identical features as uterine myoma in extrauterine sites. The most documented site is the lungs, but other areas of the body have been reported. The case of a 44-year-old woman who had BML following an earlier open myomectomy is reported. The presentation mimicked an advanced intra-abdominal tumor with lung involvement, and this posed a diagnostic dilemma, especially with the worsening breathlessness and rapid deterioration of the patient's clinical condition. Autopsy provided an insight into this rare case which was confirmed by histology and immunohistochemistry of the masses in the thoracic and abdominal cavities. BML can easily be misdiagnosed but, if promptly detected, medical and surgical management options could be lifesaving for the affected patients. There is a need for a high index of suspicion in patients who have had previous surgeries for fibroids presenting with pressure symptoms from regions other than the pelvis.
{"title":"Benign metastasizing leiomyoma: A rarely reported case in low-resource settings","authors":"A. Adeniran, O. Jimoh, O.Z Omoyiola, Adetokunbo Vaughan","doi":"10.4103/injms.injms_137_21","DOIUrl":"https://doi.org/10.4103/injms.injms_137_21","url":null,"abstract":"Benign metastasizing leiomyoma (BML) is an uncommon disorder characterized by occurrence of benign smooth muscle tumor with identical features as uterine myoma in extrauterine sites. The most documented site is the lungs, but other areas of the body have been reported. The case of a 44-year-old woman who had BML following an earlier open myomectomy is reported. The presentation mimicked an advanced intra-abdominal tumor with lung involvement, and this posed a diagnostic dilemma, especially with the worsening breathlessness and rapid deterioration of the patient's clinical condition. Autopsy provided an insight into this rare case which was confirmed by histology and immunohistochemistry of the masses in the thoracic and abdominal cavities. BML can easily be misdiagnosed but, if promptly detected, medical and surgical management options could be lifesaving for the affected patients. There is a need for a high index of suspicion in patients who have had previous surgeries for fibroids presenting with pressure symptoms from regions other than the pelvis.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":"13 1","pages":"182 - 185"},"PeriodicalIF":0.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70771822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/injms.injms_8_22
S. Patel, F. Parikh, N. Kulkarni
High anion gap metabolic acidosis is a common acid–base disorder encountered in hospitalized patients and more so in the intensive care unit. The most common causes are accumulation of lactate, ketones, and urea and ingestion of certain toxins. In the absence of these, lesser-known etiologies such as accumulation of D-lactate or pyroglutamic acid (PGA) should be suspected. PGA (5-oxoproline) is an endogenous organic acid that can accumulate in serum to cause anionic gap metabolic acidosis. This can occur with inherited defects in enzymes that participate in the y-glutamyl cycle or can be acquired in association with therapeutic paracetamol use, malnutrition, sepsis, antibiotics, and renal impairment. Our case illustrates that prompt recognition of this entity and discontinuation of offending agents such as paracetamol result in rapid recovery, thus reducing the hospital stay.
{"title":"High anion gap metabolic acidosis as a result of 5-oxoproline","authors":"S. Patel, F. Parikh, N. Kulkarni","doi":"10.4103/injms.injms_8_22","DOIUrl":"https://doi.org/10.4103/injms.injms_8_22","url":null,"abstract":"High anion gap metabolic acidosis is a common acid–base disorder encountered in hospitalized patients and more so in the intensive care unit. The most common causes are accumulation of lactate, ketones, and urea and ingestion of certain toxins. In the absence of these, lesser-known etiologies such as accumulation of D-lactate or pyroglutamic acid (PGA) should be suspected. PGA (5-oxoproline) is an endogenous organic acid that can accumulate in serum to cause anionic gap metabolic acidosis. This can occur with inherited defects in enzymes that participate in the y-glutamyl cycle or can be acquired in association with therapeutic paracetamol use, malnutrition, sepsis, antibiotics, and renal impairment. Our case illustrates that prompt recognition of this entity and discontinuation of offending agents such as paracetamol result in rapid recovery, thus reducing the hospital stay.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":"13 1","pages":"198 - 200"},"PeriodicalIF":0.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42751926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/injms.injms_4_22
R. Raghu, G. Mawari, N. Kumar, M. Daga, Sachindanand Gautam, J. Aarthi, S. Chand, Nupur Ritchie, Gunjan Rana, Shubho Acharya, P. Sen, Divyansh Chaudhary, Pratischtha Kain, N. Garg, Dhruv Bhoria
Background: Patients with chronic obstructive pulmonary disease (COPD) often have cardiovascular comorbidities. Patients of COPD with cardiovascular complications tend to have more symptoms and a higher mortality than do patients with COPD alone. There are several cardiac biomarkers such as Troponin-T, creatine phosphokinase-MB (CPK-MB), and N-terminal pro-brain natriuretic peptide (NT-proBNP) which can be used to detect cardiac dysfunction in patients of COPD. Retrospective studies suggest that plasma levels of NT-proBNP and cardiac Troponin-T are often elevated in patients with acute exacerbations of COPD and are associated with increased mortality. Aims and objectives: In this study, we assessed the presence of cardiac dysfunction in patients presenting with acute exacerbation of COPD (AECOPD) by using cardiac biomarkers proBNP, Troponin-T, and CPK-MB. Patients were followed up for 30 days to know the relationship between cardiac dysfunction and outcome in terms of repeated admissions, intensive care units (ICU) admissions, and/or mortality. Methodology: Ninety patients of AECOPD were enrolled in our study. A detailed history was taken and physical examination performed in these patients. All patients in the study were subjected to hematological and biochemical investigations. ProBNP, Troponin-T, and CPK-MB were measured within 48 h of admission as measure of cardiac dysfunction; and outcome was assessed in terms of mortality, ICU admission, and repeated admissions within 30 days of admission. Results: Among the study population, 77.77% had at least one deranged cardiac biomarker, and 18.88% of populations had all the three biomarkers of cardiac dysfunction deranged. 24 out of the 90 participants required ventilatory support in the form of noninvasive or invasive ventilation. 7.14% of the study population had repeated admissions, 24.28% had ICU admissions and 11.43% had mortality. All of them had deranged cardiac biomarkers. There was a significant association between deranged proBNP and ICU admission and mortality (P = 0.0151 and 0.0217, respectively). COPD was more prevalent in the age group of 50–70 years and in males. ProBNP levels were significantly elevated in patients who required ventilatory support (P = 0.003). Conclusions: Cardiac dysfunction is common during exacerbations of COPD and portends a poor prognosis. Cardiac dysfunction was more prevalent in the elderly. Patients with deranged cardiac biomarkers had a greater number of ICU admissions, repeated hospital admissions, and a higher mortality. In the follow-up, elevated proBNP was found to be a strong marker for predicting ICU admission, mortality, and repeated admissions.
{"title":"Role of cardiac biomarkers in patients of chronic obstructive pulmonary disease with acute exacerbation","authors":"R. Raghu, G. Mawari, N. Kumar, M. Daga, Sachindanand Gautam, J. Aarthi, S. Chand, Nupur Ritchie, Gunjan Rana, Shubho Acharya, P. Sen, Divyansh Chaudhary, Pratischtha Kain, N. Garg, Dhruv Bhoria","doi":"10.4103/injms.injms_4_22","DOIUrl":"https://doi.org/10.4103/injms.injms_4_22","url":null,"abstract":"Background: Patients with chronic obstructive pulmonary disease (COPD) often have cardiovascular comorbidities. Patients of COPD with cardiovascular complications tend to have more symptoms and a higher mortality than do patients with COPD alone. There are several cardiac biomarkers such as Troponin-T, creatine phosphokinase-MB (CPK-MB), and N-terminal pro-brain natriuretic peptide (NT-proBNP) which can be used to detect cardiac dysfunction in patients of COPD. Retrospective studies suggest that plasma levels of NT-proBNP and cardiac Troponin-T are often elevated in patients with acute exacerbations of COPD and are associated with increased mortality. Aims and objectives: In this study, we assessed the presence of cardiac dysfunction in patients presenting with acute exacerbation of COPD (AECOPD) by using cardiac biomarkers proBNP, Troponin-T, and CPK-MB. Patients were followed up for 30 days to know the relationship between cardiac dysfunction and outcome in terms of repeated admissions, intensive care units (ICU) admissions, and/or mortality. Methodology: Ninety patients of AECOPD were enrolled in our study. A detailed history was taken and physical examination performed in these patients. All patients in the study were subjected to hematological and biochemical investigations. ProBNP, Troponin-T, and CPK-MB were measured within 48 h of admission as measure of cardiac dysfunction; and outcome was assessed in terms of mortality, ICU admission, and repeated admissions within 30 days of admission. Results: Among the study population, 77.77% had at least one deranged cardiac biomarker, and 18.88% of populations had all the three biomarkers of cardiac dysfunction deranged. 24 out of the 90 participants required ventilatory support in the form of noninvasive or invasive ventilation. 7.14% of the study population had repeated admissions, 24.28% had ICU admissions and 11.43% had mortality. All of them had deranged cardiac biomarkers. There was a significant association between deranged proBNP and ICU admission and mortality (P = 0.0151 and 0.0217, respectively). COPD was more prevalent in the age group of 50–70 years and in males. ProBNP levels were significantly elevated in patients who required ventilatory support (P = 0.003). Conclusions: Cardiac dysfunction is common during exacerbations of COPD and portends a poor prognosis. Cardiac dysfunction was more prevalent in the elderly. Patients with deranged cardiac biomarkers had a greater number of ICU admissions, repeated hospital admissions, and a higher mortality. In the follow-up, elevated proBNP was found to be a strong marker for predicting ICU admission, mortality, and repeated admissions.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":"13 1","pages":"161 - 165"},"PeriodicalIF":0.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44821869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/injms.injms_147_21
F. Memon, V. Londhey, Rani Meshram, Gautami Kolhe
Brain abscesses are rare and potentially lethal neurological lesions, requiring prompt attention. Although brain abscesses are known to complicate surgically intervened intracerebral hemorrhages (ICH), but the formation of a brain abscess at the site of an ICH treated without surgery is exceptional. We hereby report a case of a 14-year-old female presenting with a brain abscess 6 weeks after an episode of spontaneous ICH with no identifiable focus of infection. She was effectively treated with antibiotics in combination with craniotomy and excision of abscess and was discharged with good recovery.
{"title":"Brain abscess at the site of recent primary intracerebral hemorrhage","authors":"F. Memon, V. Londhey, Rani Meshram, Gautami Kolhe","doi":"10.4103/injms.injms_147_21","DOIUrl":"https://doi.org/10.4103/injms.injms_147_21","url":null,"abstract":"Brain abscesses are rare and potentially lethal neurological lesions, requiring prompt attention. Although brain abscesses are known to complicate surgically intervened intracerebral hemorrhages (ICH), but the formation of a brain abscess at the site of an ICH treated without surgery is exceptional. We hereby report a case of a 14-year-old female presenting with a brain abscess 6 weeks after an episode of spontaneous ICH with no identifiable focus of infection. She was effectively treated with antibiotics in combination with craniotomy and excision of abscess and was discharged with good recovery.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":"13 1","pages":"192 - 194"},"PeriodicalIF":0.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48112813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/injms.injms_132_21
Mohsina Syed, Sumayyah Liaquat, Zainab Saleem, Jay Singh, Rabia Sana, N. Shahbaz
Context: Poststroke seizures are not infrequent neurological sequelae of stroke. Aims: The primary aim of our study is to determine the frequency of early seizures in acute ischemic stroke in our population. Subjects and Methods: It is a descriptive cross-sectional study done at the Department of Neurology, Dr. Ruth K. M. Pfau Civil Hospital Karachi, Pakistan. The duration of the study was of 6 months, from July 2019 to December 2019. All patients who fulfilled the inclusion criteria were enrolled in the study after Institutional Review Board approval. Informed and written consent was obtained from all subjects. A detailed history and clinical examination were carried out and all patients were assessed by a trained neurologist. Results: Total 281 patients with ischemic stroke were included. One hundred and eighty-one patients (64.4%) were male and 100 (35.6%) were female with a mean age of 48.41 ± 8.730 years. The early-onset seizures were noted in 22 patients (7.8%). In our study, early-onset poststroke seizures were noted more commonly in the age group of 36–60 years and were predominant in the males. Patients with infarction in the parietal lobe exhibited greater seizure occurrence. The most common seizure type observed was generalized tonic–clonic. Majority of early-onset poststroke seizures occurred in the 1st week. Conclusion: In our study, the frequency of early onset seizures in patients with ischemic stroke was found to be 7.8%, which when occurs increases morbidity.
{"title":"Early-onset seizures in ischemic stroke: A descriptive cross-sectional study","authors":"Mohsina Syed, Sumayyah Liaquat, Zainab Saleem, Jay Singh, Rabia Sana, N. Shahbaz","doi":"10.4103/injms.injms_132_21","DOIUrl":"https://doi.org/10.4103/injms.injms_132_21","url":null,"abstract":"Context: Poststroke seizures are not infrequent neurological sequelae of stroke. Aims: The primary aim of our study is to determine the frequency of early seizures in acute ischemic stroke in our population. Subjects and Methods: It is a descriptive cross-sectional study done at the Department of Neurology, Dr. Ruth K. M. Pfau Civil Hospital Karachi, Pakistan. The duration of the study was of 6 months, from July 2019 to December 2019. All patients who fulfilled the inclusion criteria were enrolled in the study after Institutional Review Board approval. Informed and written consent was obtained from all subjects. A detailed history and clinical examination were carried out and all patients were assessed by a trained neurologist. Results: Total 281 patients with ischemic stroke were included. One hundred and eighty-one patients (64.4%) were male and 100 (35.6%) were female with a mean age of 48.41 ± 8.730 years. The early-onset seizures were noted in 22 patients (7.8%). In our study, early-onset poststroke seizures were noted more commonly in the age group of 36–60 years and were predominant in the males. Patients with infarction in the parietal lobe exhibited greater seizure occurrence. The most common seizure type observed was generalized tonic–clonic. Majority of early-onset poststroke seizures occurred in the 1st week. Conclusion: In our study, the frequency of early onset seizures in patients with ischemic stroke was found to be 7.8%, which when occurs increases morbidity.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":"13 1","pages":"166 - 168"},"PeriodicalIF":0.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45939232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/injms.injms_145_21
B. Kashyap, N. Singh, K. Nirmal, M. Meena
Background: Urinary tract infections (UTIs) are one of the most common bacterial infections in humans, both in the community and the hospital settings. The distribution of antimicrobial susceptibility data of UTI-causing microorganisms changes from time to time and from place to place. The susceptibility data provided by regional microbiology laboratories helps to choose the empirical antimicrobials to treat UTI. Aim and Objectives: To determine the prevalence and antimicrobial drug susceptibility pattern of the bacterial uropathogens isolated from a tertiary care hospital. Material and Methods: A retrospective analysis over a period of two months (Jan-Feb 2021) was performed in the Department of Microbiology of a tertiary care hospital, East part of Delhi. These two months were immediately following conversion of this facility to a non COVID centre from a dedicated COVID centre. Culture results of the urine samples received during the study period were analyzed. The samples were processed according to standard guidelines. The data were entered into micro soft excel for analysis. Results: A total of 1650 urine samples from suspected UTIs were analyzed retrospectively for isolation and identification of bacteria and antimicrobial susceptibility testing. 271 (16.4%) grew significant microorganisms including fungus. In both male and female patients E. coli (n = 46, 17%) was the most commonly isolated microorganism, followed by Staphylococcus spp. (n = 45, 16%). Isolated resistance to uropathogens was common with Cotrimoxazole (60%), Nitrofurantoin (50%), ciprofloxacin (50%), tetracycline (45%), Imipenem and cefotaxime (35%) Conclusions: UTI is one of the most common infectious diseases that clinicians are dealing with. Increasing antimicrobial resistance among uropathogens implicated in UTI is a matter of concern. Periodic monitoring of etiology and drug susceptibility is recommended.
{"title":"Uropathogens and the antibiogram profile from a tertiary care hospital: A 2-month study post conversion of a COVID dedicated center to a non-COVID one","authors":"B. Kashyap, N. Singh, K. Nirmal, M. Meena","doi":"10.4103/injms.injms_145_21","DOIUrl":"https://doi.org/10.4103/injms.injms_145_21","url":null,"abstract":"Background: Urinary tract infections (UTIs) are one of the most common bacterial infections in humans, both in the community and the hospital settings. The distribution of antimicrobial susceptibility data of UTI-causing microorganisms changes from time to time and from place to place. The susceptibility data provided by regional microbiology laboratories helps to choose the empirical antimicrobials to treat UTI. Aim and Objectives: To determine the prevalence and antimicrobial drug susceptibility pattern of the bacterial uropathogens isolated from a tertiary care hospital. Material and Methods: A retrospective analysis over a period of two months (Jan-Feb 2021) was performed in the Department of Microbiology of a tertiary care hospital, East part of Delhi. These two months were immediately following conversion of this facility to a non COVID centre from a dedicated COVID centre. Culture results of the urine samples received during the study period were analyzed. The samples were processed according to standard guidelines. The data were entered into micro soft excel for analysis. Results: A total of 1650 urine samples from suspected UTIs were analyzed retrospectively for isolation and identification of bacteria and antimicrobial susceptibility testing. 271 (16.4%) grew significant microorganisms including fungus. In both male and female patients E. coli (n = 46, 17%) was the most commonly isolated microorganism, followed by Staphylococcus spp. (n = 45, 16%). Isolated resistance to uropathogens was common with Cotrimoxazole (60%), Nitrofurantoin (50%), ciprofloxacin (50%), tetracycline (45%), Imipenem and cefotaxime (35%) Conclusions: UTI is one of the most common infectious diseases that clinicians are dealing with. Increasing antimicrobial resistance among uropathogens implicated in UTI is a matter of concern. Periodic monitoring of etiology and drug susceptibility is recommended.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":"13 1","pages":"169 - 175"},"PeriodicalIF":0.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44090152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/injms.injms_32_22
T. Talukdar, N. Verma, J. Kishore, Medha Goyal, P. Ish
{"title":"Attitude, ethics, and communication skills (AETCOM) training of young doctors for COVID-19: An Indian perspective","authors":"T. Talukdar, N. Verma, J. Kishore, Medha Goyal, P. Ish","doi":"10.4103/injms.injms_32_22","DOIUrl":"https://doi.org/10.4103/injms.injms_32_22","url":null,"abstract":"","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":"13 1","pages":"205 - 207"},"PeriodicalIF":0.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48674506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/injms.injms_15_22
A. Singh, P. Agrawal, Prof Vikas Kumar
Aim: The aim is to analyze various possible etiological factors for the sudden outbreak of mucormycosis. Methods: A prospective observational study involving consecutive individuals with proven mucormycosis was undertaken at a tertiary care teaching hospital in North India from May 2021 to July 2021. A total of 88 patients with mucormycosis were studied for the demographic profile, COVID-19 status, various risk factors, COVID-19 immunization status, clinical staging of disease, and outcome of patients. Results: Out of 88 patients, 54 (61%) were males and 34 (39%) were females. The mean age of male patients was 50.5 ± 13.8 and female patients was 52.1 ± 14.1. Most of the patients were in stage two, i.e., 45 (51.1%) and 26 (29.5%) in stage three of the disease. Past history of diabetes was present in 49 (55%) patients. Forty-one (46.6%) patients had documented Reverse Transcription Polymerase Chain Reaction (RTPCR) reports in favor of COVID-19 and others had clinical features consistent with COVID-19. Only 1% of patient took COVID-vaccination. Of the total 88 patients, 42 (47%) were on oxygen therapy, 72 (81%) had history of blood transfusion, and 48 (54%) were given steroids. Conclusions: No conclusive etiological factor was identified although few recommendations are suggested for prevention, early diagnosis, and prompt management of mucormycosis in hospitalized COVID-19 patients.
{"title":"An analysis of proposed etiological factors for sudden spike in mucormycosis infection during COVID-19 pandemic at a tertiary hospital of North India","authors":"A. Singh, P. Agrawal, Prof Vikas Kumar","doi":"10.4103/injms.injms_15_22","DOIUrl":"https://doi.org/10.4103/injms.injms_15_22","url":null,"abstract":"Aim: The aim is to analyze various possible etiological factors for the sudden outbreak of mucormycosis. Methods: A prospective observational study involving consecutive individuals with proven mucormycosis was undertaken at a tertiary care teaching hospital in North India from May 2021 to July 2021. A total of 88 patients with mucormycosis were studied for the demographic profile, COVID-19 status, various risk factors, COVID-19 immunization status, clinical staging of disease, and outcome of patients. Results: Out of 88 patients, 54 (61%) were males and 34 (39%) were females. The mean age of male patients was 50.5 ± 13.8 and female patients was 52.1 ± 14.1. Most of the patients were in stage two, i.e., 45 (51.1%) and 26 (29.5%) in stage three of the disease. Past history of diabetes was present in 49 (55%) patients. Forty-one (46.6%) patients had documented Reverse Transcription Polymerase Chain Reaction (RTPCR) reports in favor of COVID-19 and others had clinical features consistent with COVID-19. Only 1% of patient took COVID-vaccination. Of the total 88 patients, 42 (47%) were on oxygen therapy, 72 (81%) had history of blood transfusion, and 48 (54%) were given steroids. Conclusions: No conclusive etiological factor was identified although few recommendations are suggested for prevention, early diagnosis, and prompt management of mucormycosis in hospitalized COVID-19 patients.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":"13 1","pages":"150 - 153"},"PeriodicalIF":0.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70771610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/injms.injms_144_21
Debasish Das, A. Banerjee, Abhinav Kumar, Tutan Das, S. Singh, J. Gupta, Manaranjan Dixit
We report a rare case of critical coronary artery disease in a 62-year-old male with achondroplasia. There is a paucity of case reports of association of achondroplasia with coronary artery disease. Left main coronary artery (LMCA) bifurcation lesion carries the highest risk of mortality out of all types of coronary artery lesions and patients with achondroplasia have two-fold more mortality as compared to the general population. That is why achondroplasia patients may be having more sudden cardiac death with the most catastrophic LMCA bifurcation lesion before they undergo revascularization. It may be the plausible explanation behind no literature description of LMCA bifurcation lesion in patients with achondroplasia. Our case is the first literature description of LMCA bifurcation lesion with successful intervention in achondroplasia. The present case will also provide a detailed insight into the association of achondroplasia with coronary artery disease without the presence of conventional cardiac risk factors.
{"title":"Left main coronary artery bifurcation coronary intervention in a patient with achondroplasia with multivessel coronary artery disease","authors":"Debasish Das, A. Banerjee, Abhinav Kumar, Tutan Das, S. Singh, J. Gupta, Manaranjan Dixit","doi":"10.4103/injms.injms_144_21","DOIUrl":"https://doi.org/10.4103/injms.injms_144_21","url":null,"abstract":"We report a rare case of critical coronary artery disease in a 62-year-old male with achondroplasia. There is a paucity of case reports of association of achondroplasia with coronary artery disease. Left main coronary artery (LMCA) bifurcation lesion carries the highest risk of mortality out of all types of coronary artery lesions and patients with achondroplasia have two-fold more mortality as compared to the general population. That is why achondroplasia patients may be having more sudden cardiac death with the most catastrophic LMCA bifurcation lesion before they undergo revascularization. It may be the plausible explanation behind no literature description of LMCA bifurcation lesion in patients with achondroplasia. Our case is the first literature description of LMCA bifurcation lesion with successful intervention in achondroplasia. The present case will also provide a detailed insight into the association of achondroplasia with coronary artery disease without the presence of conventional cardiac risk factors.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":"13 1","pages":"188 - 191"},"PeriodicalIF":0.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42245701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/injms.injms_78_22
S. Dwivedi
{"title":"Interface between humanities, spirituality, and medical science in ramacharitmanasa","authors":"S. Dwivedi","doi":"10.4103/injms.injms_78_22","DOIUrl":"https://doi.org/10.4103/injms.injms_78_22","url":null,"abstract":"","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":"13 1","pages":"139 - 142"},"PeriodicalIF":0.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45690042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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