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BIOENERGETIC DIFFERENCES DURING WALKING AND RUNNING IN TRANSFEMORAL AMPUTEE RUNNERS USING ARTICULATING AND NON-ARTICULATING KNEE PROSTHESES. 使用关节和非关节膝关节假体的经股骨截肢跑步者行走和跑步时的生物能量差异。
IF 0.5 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2016-09-01 DOI: 10.21300/18.2-3.2016.159
M. J. Highsmith, Jason T. Kahle, Rebecca M Miro, L. Mengelkoch
Transfemoral amputation (TFA) patients require considerably more energy to walk and run than non-amputees. The purpose of this study was to examine potential bioenergetic differences (oxygen uptake (VO2), heart rate (HR), and ratings of perceived exertion (RPE)) for TFA patients utilizing a conventional running prosthesis with an articulating knee mechanism versus a running prosthesis with a non-articulating knee joint. Four trained TFA runners (n = 4) were accommodated to and tested with both conditions. VO2 and HR were significantly lower (p ≤ 0.05) in five of eight fixed walking and running speeds for the prosthesis with an articulating knee mechanism. TFA demonstrated a trend for lower RPE at six of eight walking speeds using the prosthesis with the articulated knee condition. A trend was observed for self-selected walking speed, self-selected running speed, and maximal speed to be faster for TFA subjects using the prosthesis with the articulated knee condition. Finally, all four TFA participants subjectively preferred running with the prosthesis with the articulated knee condition. These findings suggest that, for trained TFA runners, a running prosthesis with an articulating knee prosthesis reduces ambulatory energy costs and enhances subjective perceptive measures compared to using a non-articulating knee prosthesis.
经股骨截肢(TFA)患者比非截肢者需要更多的能量来行走和跑步。本研究的目的是检查TFA患者使用带关节的传统跑步假体与不带关节的跑步假体的潜在生物能量差异(摄氧量(VO2)、心率(HR)和感知运动评分(RPE))。四名训练有素的TFA跑步者(n = 4)被适应并接受了两种条件的测试。在8个固定步行和跑步速度中,有5个固定步行和跑步速度的VO2和HR显著降低(p≤0.05)。使用关节膝关节的假体,在8种行走速度中的6种下,TFA显示出较低RPE的趋势。使用关节膝关节假体的TFA受试者的自选步行速度、自选跑步速度和最大速度有较快的趋势。最后,所有四名TFA参与者主观上都更喜欢在膝关节关节状况下使用假体跑步。这些发现表明,对于训练有素的TFA跑步者来说,与使用非关节膝关节假体相比,带有关节膝关节假体的跑步假体减少了运动能量消耗,增强了主观感知能力。
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引用次数: 7
Gait Training Interventions for Lower Extremity Amputees: A Systematic Literature Review. 步态训练干预下肢截肢者:系统的文献综述。
IF 0.5 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2016-09-01 DOI: 10.21300/18.2-3.2016.99
M. J. Highsmith, Casey R Andrews, Claire Millman, Ashley Fuller, Jason T. Kahle, Tyler D. Klenow, Katherine L Lewis, Rachel C Bradley, John J Orriola
Lower extremity (LE) amputation patients who use prostheses have gait asymmetries and altered limb loading and movement strategies when ambulating. Subsequent secondary conditions are believed to be associated with gait deviations and lead to long-term complications that impact function and quality of life as a result. The purpose of this study was to systematically review the literature to determine the strength of evidence supporting gait training interventions and to formulate evidence statements to guide practice and research related to therapeutic gait training for lower extremity amputees. A systematic review of three databases was conducted followed by evaluation of evidence and synthesis of empirical evidence statements (EES). Eighteen manuscripts were included in the review, which covered two areas of gait training interventions: 1) overground and 2) treadmill-based. Eight EESs were synthesized. Four addressed overground gait training, one covered treadmill training, and three statements addressed both forms of therapy. Due to the gait asymmetries, altered biomechanics, and related secondary consequences associated with LE amputation, gait training interventions are needed along with study of their efficacy. Overground training with verbal or other auditory, manual, and psychological awareness interventions was found to be effective at improving gait. Similarly, treadmill-based training was found to be effective: 1) as a supplement to overground training; 2) independently when augmented with visual feedback and/or body weight support; or 3) as part of a home exercise plan. Gait training approaches studied improved multiple areas of gait, including sagittal and coronal biomechanics, spatiotemporal measures, and distance walked.
下肢(LE)截肢患者使用假肢时步态不对称,肢体负荷和运动策略改变。随后的继发性疾病被认为与步态偏差有关,并导致影响功能和生活质量的长期并发症。本研究的目的是系统地回顾文献,以确定支持步态训练干预的证据强度,并制定证据陈述,以指导与下肢截肢者治疗性步态训练相关的实践和研究。对三个数据库进行了系统回顾,随后进行了证据评估和经验证据陈述(EES)的合成。这篇综述收录了18篇手稿,涵盖了步态训练干预的两个领域:1)地面训练和2)基于跑步机的训练。合成了8个EESs。四项涉及地面步态训练,一项涉及跑步机训练,三项涉及两种形式的治疗。由于步态不对称、生物力学改变以及与左下肢截肢相关的继发性后果,需要进行步态训练干预并研究其疗效。口头或其他听觉、手动和心理意识干预的地面训练被发现对改善步态是有效的。同样,基于跑步机的训练被发现是有效的:1)作为地上训练的补充;2)在视觉反馈和/或体重支持下独立;或者3)作为家庭锻炼计划的一部分。步态训练方法研究了步态的多个领域,包括矢状面和冠状面生物力学、时空测量和步行距离。
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引用次数: 55
Diffusion Imaging Fiber Bundles 扩散成像光纤束
IF 0.5 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2016-05-18 DOI: 10.21300/18.1.2016.31
Song Zhang
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引用次数: 0
Using Pittsburgh Compound B for PET Imaging Across The Alzheimer's Disease Spectrum 利用匹兹堡化合物B对阿尔茨海默病谱进行PET成像
IF 0.5 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2016-05-18 DOI: 10.21300/18.1.2016.51
A. Cohen
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引用次数: 3
Assessing the Structural and Functional Effects of Neuromodulation Using Magnetic Resonance Imaging 磁共振成像评估神经调节的结构和功能影响
IF 0.5 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2016-05-18 DOI: 10.21300/18.1.2016.39
D. Tate, Jacob D. Bolzenius, C. Velez, E. Wilde, S. Bouix, C. Jaramillo, Jeffrey D. Lewis, M. Weisend
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引用次数: 1
The Emerging Field of Perivascular Flow Dynamics: Biological Relevance and Clinical Applications 血管周围血流动力学的新兴领域:生物学相关性和临床应用
IF 0.5 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2016-05-18 DOI: 10.21300/18.1.2016.63
Jacob N. Huffman, Sarah Phillips, George T. Taylor, Robert Paul
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引用次数: 6
The Pillars of Patent Quality 专利质量的支柱
IF 0.5 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2016-05-18 DOI: 10.21300/18.1.2016.75
A. Camarota
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引用次数: 2
Introduction: Evolution of Neuroimaging Technology In the Modern Era 导论:现代神经影像技术的演变
IF 0.5 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2016-05-18 DOI: 10.21300/18.1.2016.1
R. Paul
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引用次数: 2
The NAI Fellow Profile: An Interview with Dr. Frances Arnold NAI研究员简介:采访弗朗西丝·阿诺德博士
IF 0.5 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2016-05-18 DOI: 10.21300/18.1.2016.79
Frances Arnold, Kimberly A. Macuare
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引用次数: 1
REDUCING CSF PARTIAL VOLUME EFFECTS TO ENHANCE DIFFUSION TENSOR IMAGING METRICS OF BRAIN MICROSTRUCTURE. 减少脑脊液部分容积效应增强脑微结构弥散张量成像指标。
IF 0.5 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2016-04-01 DOI: 10.21300/18.1.2016.5
Lauren E. Salminen, T. Conturo, Jacob D. Bolzenius, R. Cabeen, E. Akbudak, R. Paul
Technological advances over recent decades now allow for in vivo observation of human brain tissue through the use of neuroimaging methods. While this field originated with techniques capable of capturing macrostructural details of brain anatomy, modern methods such as diffusion tensor imaging (DTI) that are now regularly implemented in research protocols have the ability to characterize brain microstructure. DTI has been used to reveal subtle micro-anatomical abnormalities in the prodromal phase ofº various diseases and also to delineate "normal" age-related changes in brain tissue across the lifespan. Nevertheless, imaging artifact in DTI remains a significant limitation for identifying true neural signatures of disease and brain-behavior relationships. Cerebrospinal fluid (CSF) contamination of brain voxels is a main source of error on DTI scans that causes partial volume effects and reduces the accuracy of tissue characterization. Several methods have been proposed to correct for CSF artifact though many of these methods introduce new limitations that may preclude certain applications. The purpose of this review is to discuss the complexity of signal acquisition as it relates to CSF artifact on DTI scans and review methods of CSF suppression in DTI. We will then discuss a technique that has been recently shown to effectively suppress the CSF signal in DTI data, resulting in fewer errors and improved measurement of brain tissue. This approach and related techniques have the potential to significantly improve our understanding of "normal" brain aging and neuropsychiatric and neurodegenerative diseases. Considerations for next-level applications are discussed.
近几十年来的技术进步现在允许通过使用神经成像方法对人体脑组织进行体内观察。虽然这一领域起源于能够捕捉大脑解剖学宏观结构细节的技术,但现在在研究协议中经常实施的扩散张量成像(DTI)等现代方法具有表征大脑微观结构的能力。DTI已被用于揭示各种疾病前驱期细微的微观解剖异常,也用于描绘整个生命周期中脑组织中与年龄相关的“正常”变化。然而,DTI中的成像伪影仍然是识别疾病和脑行为关系的真实神经特征的重大限制。脑脊液(CSF)对脑体素的污染是DTI扫描误差的主要来源,它会导致部分体积效应,降低组织表征的准确性。已经提出了几种方法来纠正CSF伪影,尽管其中许多方法引入了新的限制,可能会妨碍某些应用。这篇综述的目的是讨论信号采集的复杂性,因为它与DTI扫描的CSF伪影有关,并回顾DTI中CSF抑制的方法。然后,我们将讨论最近显示的一种技术,该技术可以有效地抑制DTI数据中的CSF信号,从而减少误差并改善脑组织的测量。这种方法和相关技术有可能显著提高我们对“正常”大脑衰老、神经精神和神经退行性疾病的理解。讨论了下一级应用程序的注意事项。
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引用次数: 32
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