Pub Date : 2021-08-05eCollection Date: 2021-08-01DOI: 10.36401/JIPO-21-2
Kevin Tang, Loretta J Nastoupil
Chimeric antigen receptor (CAR) T cell therapy has emerged as a revolutionary treatment option for highly aggressive B cell malignancies. Clinical trials of CD19 CAR T cells for the management of relapsed and/or refractory non-Hodgkin lymphoma (NHL) have shown markedly improved survival and response rates. The goal of this review is to evaluate whether the results from these clinical trials are reflective of real-world practices through the analysis of published literature of the commercially available CAR T cell products. We have found that despite the significantly different patient characteristics, the adverse events and response rates of real-world patients were similar to those of the clinical trials. Of interest, several groups excluded from the clinical trials, such as patients with HIV infection, chronic viral hepatitis, and secondary CNS (central nervous system) lymphoma, had case reports of promising outcomes.
嵌合抗原受体（CAR）T 细胞疗法已成为高度侵袭性 B 细胞恶性肿瘤的革命性治疗选择。用 CD19 CAR T 细胞治疗复发和/或难治性非霍奇金淋巴瘤（NHL）的临床试验显示，患者的生存率和反应率明显提高。本综述的目的是通过分析已发表的有关市售 CAR T 细胞产品的文献，评估这些临床试验的结果是否反映了真实世界的实践。我们发现，尽管患者的特征明显不同，但真实世界中患者的不良事件和反应率与临床试验中的相似。值得关注的是，一些被临床试验排除在外的群体，如艾滋病病毒感染、慢性病毒性肝炎和继发性中枢神经系统（CNS）淋巴瘤患者，也有取得良好疗效的病例报告。
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Pub Date : 2021-07-03DOI: 10.1080/00182370.2021.2017609
Robert Shaffer
of any kind of gender politics that may have affected his mother’s silence, nor is he alert to the possibility that her silence (more complete than his father’s) was connected to sexual trauma she may have experienced or witnessed. Harootunian’s central goals of bringing the everyday experience of genocide survivors into historical understanding and of understanding the way in which the unspoken is his heritage are both laudable ones, but they would have been better served by a more thorough exploration of extant oral and social historical literature on the subject.
{"title":"You never forget your first: a biography of George Washington","authors":"Robert Shaffer","doi":"10.1080/00182370.2021.2017609","DOIUrl":"https://doi.org/10.1080/00182370.2021.2017609","url":null,"abstract":"of any kind of gender politics that may have affected his mother’s silence, nor is he alert to the possibility that her silence (more complete than his father’s) was connected to sexual trauma she may have experienced or witnessed. Harootunian’s central goals of bringing the everyday experience of genocide survivors into historical understanding and of understanding the way in which the unspoken is his heritage are both laudable ones, but they would have been better served by a more thorough exploration of extant oral and social historical literature on the subject.","PeriodicalId":44078,"journal":{"name":"HISTORIAN","volume":"83 1","pages":"391 - 392"},"PeriodicalIF":0.2,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45237801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-03DOI: 10.1080/00182370.2021.2018299
A. E. Eckes
{"title":"Getting right with Reagan: the struggle for true conservatism, 1980-2016","authors":"A. E. Eckes","doi":"10.1080/00182370.2021.2018299","DOIUrl":"https://doi.org/10.1080/00182370.2021.2018299","url":null,"abstract":"","PeriodicalId":44078,"journal":{"name":"HISTORIAN","volume":"83 1","pages":"404 - 405"},"PeriodicalIF":0.2,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45942794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-03DOI: 10.1080/00182370.2021.2018389
Stefano U. Baldassarri
{"title":"Giannozzo Manetti: the life of a Florentine humanist","authors":"Stefano U. Baldassarri","doi":"10.1080/00182370.2021.2018389","DOIUrl":"https://doi.org/10.1080/00182370.2021.2018389","url":null,"abstract":"","PeriodicalId":44078,"journal":{"name":"HISTORIAN","volume":"83 1","pages":"415 - 418"},"PeriodicalIF":0.2,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46153754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-03DOI: 10.1080/00182370.2021.2018388
Susanna Kokkonen
behavior, and political organization have persisted beyond the dictator’s death and the democratic transition. If “the uncertainty about the dictatorship’s ending was a feature of the Francoist era,” she writes, uncertainty “persists today, albeit in an inverted form: . . . as a critique of the regime’s continued presence within Spanish democracy”: “While the regime was haunted by the prospect of its ending, the postFranco era is haunted by the dictatorship’s non-ending” (5, 7). It is best to read this book less as a standard scholarly monograph – for which the bibliography is too eclectic and the dialogue with existing specialized scholarship too spotty – than as an essayistic, nuanced, theoretically informed reflection that, in turn, invites its readers to question their assumptions about the last 90 years of Spanish history.
{"title":"Hitler’s Jewish refugees: hope and anxiety in Portugal","authors":"Susanna Kokkonen","doi":"10.1080/00182370.2021.2018388","DOIUrl":"https://doi.org/10.1080/00182370.2021.2018388","url":null,"abstract":"behavior, and political organization have persisted beyond the dictator’s death and the democratic transition. If “the uncertainty about the dictatorship’s ending was a feature of the Francoist era,” she writes, uncertainty “persists today, albeit in an inverted form: . . . as a critique of the regime’s continued presence within Spanish democracy”: “While the regime was haunted by the prospect of its ending, the postFranco era is haunted by the dictatorship’s non-ending” (5, 7). It is best to read this book less as a standard scholarly monograph – for which the bibliography is too eclectic and the dialogue with existing specialized scholarship too spotty – than as an essayistic, nuanced, theoretically informed reflection that, in turn, invites its readers to question their assumptions about the last 90 years of Spanish history.","PeriodicalId":44078,"journal":{"name":"HISTORIAN","volume":"83 1","pages":"414 - 415"},"PeriodicalIF":0.2,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47345782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-03DOI: 10.1080/00182370.2021.2018283
Ross Phillips
{"title":"How the few became the proud: crafting the Marine Corps mystique, 1874-1918","authors":"Ross Phillips","doi":"10.1080/00182370.2021.2018283","DOIUrl":"https://doi.org/10.1080/00182370.2021.2018283","url":null,"abstract":"","PeriodicalId":44078,"journal":{"name":"HISTORIAN","volume":"83 1","pages":"399 - 401"},"PeriodicalIF":0.2,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47899967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-03DOI: 10.1080/00182370.2021.1999049
C. McDaniel
ABSTRACT Since the late nineteenth century, the landscapist Isaak Levitan (1860–1900) has been praised for his ability to convey the Russian countryside’s beauty and mood. Throughout the czarist and Soviet eras, Levitan remained respected and often admired, and in post-Soviet Russia, Levitan is considered one of Russia’s foremost landscapists. Although Levitan has remained an important figure in Russian cultural history, he is somewhat understudied in the English-speaking world. Moreover, scholars who have discussed Levitan in English- and Russian-language publications have situated him within the context of a specific timeframe, such as late-Imperial Russia or the Soviet era. In order to gain insight into the reasons for the continuous respect and appreciation for Levitan amid Russia’s changing political dynamics, my examination focuses upon the writings of art critics and historians in late-czarist/imperial Russia (1890–1917), communist Russia/Soviet Union (1917–1991), and post-Soviet Russia (1991-Present). Specifically, my inquiry expands upon existing research 1) through an analysis of scholars’ perceptions of the Russian Realists’ (the Itinerants) and Western European artists’ influence upon Levitan, and 2) through an exploration of the varying interpretations of two of his most famous paintings, Tikhaia obitel (Quiet Monastery) (1890) and Nad vechnym pokoem (Above Eternal Peace) (1894). Through a study of these two topics, my article demonstrates that writings from scholars in the late-czarist, Soviet and post-Soviet eras reflect prominent political ideas and ideological beliefs within these three eras, and that these scholars’ interpretations emphasize aspects that have defined and that currently accent Russia’s distinct character.
{"title":"Isaak Levitan’s enduring appeal and Russian national identity, 1891-present","authors":"C. McDaniel","doi":"10.1080/00182370.2021.1999049","DOIUrl":"https://doi.org/10.1080/00182370.2021.1999049","url":null,"abstract":"ABSTRACT Since the late nineteenth century, the landscapist Isaak Levitan (1860–1900) has been praised for his ability to convey the Russian countryside’s beauty and mood. Throughout the czarist and Soviet eras, Levitan remained respected and often admired, and in post-Soviet Russia, Levitan is considered one of Russia’s foremost landscapists. Although Levitan has remained an important figure in Russian cultural history, he is somewhat understudied in the English-speaking world. Moreover, scholars who have discussed Levitan in English- and Russian-language publications have situated him within the context of a specific timeframe, such as late-Imperial Russia or the Soviet era. In order to gain insight into the reasons for the continuous respect and appreciation for Levitan amid Russia’s changing political dynamics, my examination focuses upon the writings of art critics and historians in late-czarist/imperial Russia (1890–1917), communist Russia/Soviet Union (1917–1991), and post-Soviet Russia (1991-Present). Specifically, my inquiry expands upon existing research 1) through an analysis of scholars’ perceptions of the Russian Realists’ (the Itinerants) and Western European artists’ influence upon Levitan, and 2) through an exploration of the varying interpretations of two of his most famous paintings, Tikhaia obitel (Quiet Monastery) (1890) and Nad vechnym pokoem (Above Eternal Peace) (1894). Through a study of these two topics, my article demonstrates that writings from scholars in the late-czarist, Soviet and post-Soviet eras reflect prominent political ideas and ideological beliefs within these three eras, and that these scholars’ interpretations emphasize aspects that have defined and that currently accent Russia’s distinct character.","PeriodicalId":44078,"journal":{"name":"HISTORIAN","volume":"83 1","pages":"323 - 355"},"PeriodicalIF":0.2,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45962158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-03DOI: 10.1080/00182370.2021.2018282
Jeffrey P. Beck
{"title":"Native hoops: the rise of American Indian basketball, 1895-1970","authors":"Jeffrey P. Beck","doi":"10.1080/00182370.2021.2018282","DOIUrl":"https://doi.org/10.1080/00182370.2021.2018282","url":null,"abstract":"","PeriodicalId":44078,"journal":{"name":"HISTORIAN","volume":"83 1","pages":"398 - 399"},"PeriodicalIF":0.2,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45174983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-03DOI: 10.1080/00182370.2021.2018371
S. Faber
{"title":"Paradoxes of stasis: literature, politics, and thought in Francoist Spain","authors":"S. Faber","doi":"10.1080/00182370.2021.2018371","DOIUrl":"https://doi.org/10.1080/00182370.2021.2018371","url":null,"abstract":"","PeriodicalId":44078,"journal":{"name":"HISTORIAN","volume":"83 1","pages":"413 - 414"},"PeriodicalIF":0.2,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49447527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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