Ahmad Rafi Satrio Prayogo, E. Yunita, Rachmawaddah Yolanda, I. Fahri, Novriantika Lestari, M. Asteria, A. A. Nasution, Jusup Endang, Sipriyadi, Ellen Maidia Djatmiko
Introduction: Carotid intima-media thickness (CIMT) is a predictor marker of subclinical atherosclerosis that can be measured by ultrasound technique. The clinical symptoms of atherosclerosis usually begin with the thickening of the carotid artery walls. Polymorphism in Apolipoprotein E4 (APO-E4) is considered to be an important genetic determinant of atherosclerosis and Coronary Artery Disease (CAD). The genetic role of APO-E4 on plasma lipid has shown that the APO-E4 allele is associated with increased plasma LDL and total lipid concentration. The main objectives of this study were to identify genotype polymorphisms of the APO-E gene and measure the thickness of the carotid intima in subjects with APO-E4 polymorphisms in the first descendant of coronary heart patients. Patients and methods: A cross-sectional study design was used to determine the polymorphism of the APO-E4 genotype in the first descendant of CAD and non-CAD groups. There were 21 samples in each group. Gene polymorphism examination was carried out by PCR and the CIMT was measured with doppler ultrasound. Results: The result showed that 21.4% of subjects had polymorphism of the APO-E4 genotype with a significant difference between CHD and non-CHD group. This data shows that the APO-E4 genotype is more dominant in the first descendant of patients with CHD when compared to non-CHD parents. The mean values of CIMT ini right and left-sided carotid arteries among APO-E4 genotype and non-APO-E4 genotype were 0.4743 mm vs. 0.4195 mm and bivariate analysis showed a significant difference with a P-value of 0.017. This shows that there is a significant difference in the thickness of the carotid intima in the first descendant of subjects who have the APO-E4 genotype and those who do not. Conclusion: The APO-E4 gene polymorphism was more dominant in the first descendant of CAD patients with a higher CIMT mean value.
{"title":"Carotid intima-media thickness in the first descendant of coronary artery disease patients with Apolipoprotein-E4 genotype","authors":"Ahmad Rafi Satrio Prayogo, E. Yunita, Rachmawaddah Yolanda, I. Fahri, Novriantika Lestari, M. Asteria, A. A. Nasution, Jusup Endang, Sipriyadi, Ellen Maidia Djatmiko","doi":"10.15562/bmj.v11i3.3798","DOIUrl":"https://doi.org/10.15562/bmj.v11i3.3798","url":null,"abstract":"Introduction: Carotid intima-media thickness (CIMT) is a predictor marker of subclinical atherosclerosis that can be measured by ultrasound technique. The clinical symptoms of atherosclerosis usually begin with the thickening of the carotid artery walls. Polymorphism in Apolipoprotein E4 (APO-E4) is considered to be an important genetic determinant of atherosclerosis and Coronary Artery Disease (CAD). The genetic role of APO-E4 on plasma lipid has shown that the APO-E4 allele is associated with increased plasma LDL and total lipid concentration. The main objectives of this study were to identify genotype polymorphisms of the APO-E gene and measure the thickness of the carotid intima in subjects with APO-E4 polymorphisms in the first descendant of coronary heart patients.\u0000Patients and methods: A cross-sectional study design was used to determine the polymorphism of the APO-E4 genotype in the first descendant of CAD and non-CAD groups. There were 21 samples in each group. Gene polymorphism examination was carried out by PCR and the CIMT was measured with doppler ultrasound.\u0000Results: The result showed that 21.4% of subjects had polymorphism of the APO-E4 genotype with a significant difference between CHD and non-CHD group. This data shows that the APO-E4 genotype is more dominant in the first descendant of patients with CHD when compared to non-CHD parents. The mean values of CIMT ini right and left-sided carotid arteries among APO-E4 genotype and non-APO-E4 genotype were 0.4743 mm vs. 0.4195 mm and bivariate analysis showed a significant difference with a P-value of 0.017. This shows that there is a significant difference in the thickness of the carotid intima in the first descendant of subjects who have the APO-E4 genotype and those who do not.\u0000Conclusion: The APO-E4 gene polymorphism was more dominant in the first descendant of CAD patients with a higher CIMT mean value. ","PeriodicalId":44369,"journal":{"name":"Bali Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44277795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Sayuti, Muhammad Syahriza, Ghisca Chairiyah Ami
Introduction: Colorectal cancer still causes high morbidity and death rates worldwide. This study aims to determine the histopathology of colorectal cancer at Cut Meutia Hospital, North Aceh Regency in 2017-2020. Methods: This research is descriptive with a cross-sectional approach. The total sample of 64 CRC patients was taken by total sampling that met the inclusion and exclusion criteria. Results: Univariate data analysis showed that the most histopathological type of research was found in Adenocarcinoma, amounting to 55 people (88.7%). The anatomical location of cancer was found mostly in the rectum, amounting to 26 people (41.9%). Description of the characteristics according to age and gender was mostly at the age of 45-54 years, amounting to 21 people (33.9%) and male gender which amounted to 36 people (58.1%). Conclusion: The study showed the distribution of age in CRC patients at Cut Meutia Hospital, North Aceh Regency in 2017-2020, the most were at the age of 45-54 years. The description of characteristics according to gender in CRC patients, most of them were male. This study showed the anatomical location of cancer in CRC patients was more commonly found in the rectum. The histopathology type of CRC was mostly found in Adenocarcinoma.
{"title":"Histopathology of colorectal cancer in Cut Meutia Hospital, Aceh-Indonesia from 2017-2020","authors":"M. Sayuti, Muhammad Syahriza, Ghisca Chairiyah Ami","doi":"10.15562/bmj.v11i3.3750","DOIUrl":"https://doi.org/10.15562/bmj.v11i3.3750","url":null,"abstract":"Introduction: Colorectal cancer still causes high morbidity and death rates worldwide. This study aims to determine the histopathology of colorectal cancer at Cut Meutia Hospital, North Aceh Regency in 2017-2020.\u0000Methods: This research is descriptive with a cross-sectional approach. The total sample of 64 CRC patients was taken by total sampling that met the inclusion and exclusion criteria.\u0000Results: Univariate data analysis showed that the most histopathological type of research was found in Adenocarcinoma, amounting to 55 people (88.7%). The anatomical location of cancer was found mostly in the rectum, amounting to 26 people (41.9%). Description of the characteristics according to age and gender was mostly at the age of 45-54 years, amounting to 21 people (33.9%) and male gender which amounted to 36 people (58.1%).\u0000Conclusion: The study showed the distribution of age in CRC patients at Cut Meutia Hospital, North Aceh Regency in 2017-2020, the most were at the age of 45-54 years. The description of characteristics according to gender in CRC patients, most of them were male. This study showed the anatomical location of cancer in CRC patients was more commonly found in the rectum. The histopathology type of CRC was mostly found in Adenocarcinoma.","PeriodicalId":44369,"journal":{"name":"Bali Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47181284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Supriyatiningsih Wenang, I. Rismawati, Lidia Febrianti, Bambang Edi Susyanto, Gina Puspita, Alfaina Wahyuni, Arlina Dewi, Dianita Sugiyo, Sutantri, Diyah Nahdiyati, A. W. Nirwansyah
Introduction: The COVID-19 pandemic has impacted the community's disruption of nutrition and health services, including the closure of an integrated healthcare center (posyandu) in many areas in Indonesia. Posyandu plays an important role in nutrition services, particularly in detecting and managing growth and development disorders, such as stunting. This study aims to identify the improvement of knowledge in health cadres and community leaders in areas with high cases of severe acute malnutrition (SAM), namely, Temon, Kalibawang, and Dekso subdistricts in Kulon Progo, DIY, which followed a capacity-building program about strengthening the role of the community in the delivery of nutrition programs. Methods: The program was conducted through interactive online seminars to ensure the continuity of essential nutrition care services during this pandemic. This study used a one-group pre-test and post-test design. Knowledge measurement was conducted in three consecutive online seminars with 180 participants: health cadres/volunteers, village heads, community leaders, nursery/early years teachers, and academicians. The pre-test and post-test questionnaires were spread through Google Forms before and after online seminars and assessed using the Wilcoxon Signed Ranks Test. Results: The results showed that the participants improved their knowledge in webinars I and III (p-value 0.001). However, there was no significant improvement in the participants’ knowledge in webinar II (p-value 0.251). Conclusions: Multi-sectoral collaboration among the government, community leaders, health cadres, health professionals, non-government organizations, institutions, and nursery/early years teachers are needed to reduce stunting, particularly in pandemic situations.
{"title":"Strengthening community roles to reduce stunting in COVID-19 pandemic in indonesia rural areas: capacity building program for cadres and local government","authors":"Supriyatiningsih Wenang, I. Rismawati, Lidia Febrianti, Bambang Edi Susyanto, Gina Puspita, Alfaina Wahyuni, Arlina Dewi, Dianita Sugiyo, Sutantri, Diyah Nahdiyati, A. W. Nirwansyah","doi":"10.15562/bmj.v11i3.3753","DOIUrl":"https://doi.org/10.15562/bmj.v11i3.3753","url":null,"abstract":"Introduction: The COVID-19 pandemic has impacted the community's disruption of nutrition and health services, including the closure of an integrated healthcare center (posyandu) in many areas in Indonesia. Posyandu plays an important role in nutrition services, particularly in detecting and managing growth and development disorders, such as stunting. This study aims to identify the improvement of knowledge in health cadres and community leaders in areas with high cases of severe acute malnutrition (SAM), namely, Temon, Kalibawang, and Dekso subdistricts in Kulon Progo, DIY, which followed a capacity-building program about strengthening the role of the community in the delivery of nutrition programs.\u0000Methods: The program was conducted through interactive online seminars to ensure the continuity of essential nutrition care services during this pandemic. This study used a one-group pre-test and post-test design. Knowledge measurement was conducted in three consecutive online seminars with 180 participants: health cadres/volunteers, village heads, community leaders, nursery/early years teachers, and academicians. The pre-test and post-test questionnaires were spread through Google Forms before and after online seminars and assessed using the Wilcoxon Signed Ranks Test.\u0000Results: The results showed that the participants improved their knowledge in webinars I and III (p-value 0.001). However, there was no significant improvement in the participants’ knowledge in webinar II (p-value 0.251).\u0000Conclusions: Multi-sectoral collaboration among the government, community leaders, health cadres, health professionals, non-government organizations, institutions, and nursery/early years teachers are needed to reduce stunting, particularly in pandemic situations.","PeriodicalId":44369,"journal":{"name":"Bali Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48336063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I Made Pande Dwipayana, Wira Gotera, Ketut Suastika, I Wayan Putu Sutirta Yasa, Anak Agung Gede Budhiarta, Made Ratna Saraswati, I Made Siswadi Semadi, Ida Bagus Aditya Nugraha
Background: Obesity is an inflammatory condition that results in an increase in high sensitive C-Reactive Protein (hs-CRP), a risk for insulin resistance (IR). Vaspin has the effect of increasing insulin receptor sensitivity and on the other hand is a compensatory response to insulin resistance, one of which is measured by homeostasis models assessment-insulin resistance (HOMA-IR). This study was an analytical cross-sectional observational design, to determine the association between insulin, glucagon, CRP, and HOMA-IR levels with serum vaspin in obesity. Method: This study is an analytical study with a cross-sectional design. Criteria of inclusion were subjects in the range 18-60 years Denpasar citizen with BMI above 25 kg/m2 and willing to be involved in this study, while exclusion criteria were with either chronic conditions or acute inflammation such as infection, cancer, tumor, or chronic disease which is altered and threatening life. Correlation tests using spearman analysis. Results: From 131 obese subjects in this study, there were 72 (55%) men and 59 (45%) women. Median age: 33 (22-57) years, fasting insulin: 8.90 (2.20-74.50) ìIU/mL, glucagon: 48.10 (7.58-293.90) pq/mL, hs-CRP: 1.90 (0.20-9.50) mg/L, HOMA-IR: 2 (0.50-23.15), and vaspin levels: 0.16 (0.04-1.46) ng/mL. There was a significant positive correlation between HOMA-IR, insulin and glucagon with vaspin (r = 0.20, p = 0.020; r = 0.20, p = 0.022; and r = 0.28, p = 0.001), and a significant negative correlation between hs-CRP and vaspin (r = -0.24, p = 0.005) in obesity. In the path analysis, there was a direct and total negative effect of hs-CRP on vaspin (coefficient = -0.19; p = 0.027 and coefficient = -0.02; p = 0.038). Conclusion: This study shows a positive association between insulin, glucagon, and HOMA-IR with serum vaspin, while CRP is negatively associated with serum vaspin in obesity.
背景:肥胖是一种炎症性疾病，可导致高敏c反应蛋白(hs-CRP)升高，从而增加胰岛素抵抗(IR)的风险。Vaspin一方面具有增加胰岛素受体敏感性的作用，另一方面是对胰岛素抵抗的代偿反应，其中一个是通过稳态模型评估-胰岛素抵抗(HOMA-IR)来测量的。本研究是一项分析性横断面观察设计，旨在确定肥胖患者胰岛素、胰高血糖素、CRP和HOMA-IR水平与血清血管素之间的关系。方法:采用横断面设计的分析性研究。纳入标准为18-60岁的登巴萨市民，BMI高于25 kg/m2，愿意参与本研究，排除标准为慢性疾病或急性炎症，如感染、癌症、肿瘤或慢性疾病，改变和威胁生命。使用spearman分析进行相关检验。结果:131例肥胖患者中，男性72例(55%)，女性59例(45%)。中位年龄:33(22-57)岁，空腹胰岛素:8.90 (2.20-74.50)ìIU/mL，胰高血糖素:48.10 (7.58-293.90)pq/mL, hs-CRP: 1.90 (0.20-9.50) mg/L, HOMA-IR: 2 (0.50-23.15)， vaspin水平:0.16 (0.04-1.46)ng/mL。HOMA-IR、胰岛素、胰高血糖素与vaspin呈显著正相关(r = 0.20, p = 0.020;R = 0.20, p = 0.022;(r = 0.28, p = 0.001)，肥胖患者hs-CRP与vaspin呈显著负相关(r = -0.24, p = 0.005)。通径分析中，hs-CRP对vaspin有直接和总负作用(系数= -0.19;P = 0.027，系数= -0.02;P = 0.038)。结论:本研究显示肥胖患者胰岛素、胰高血糖素、HOMA-IR与血清vaspin呈正相关，而CRP与血清vaspin呈负相关。
{"title":"Association between insulin, glucagon, high sensitive c-reactive protein, insulin resistance with visceral adipose tissue-derived serine protease inhibitor (VASPIN) in obese population","authors":"I Made Pande Dwipayana, Wira Gotera, Ketut Suastika, I Wayan Putu Sutirta Yasa, Anak Agung Gede Budhiarta, Made Ratna Saraswati, I Made Siswadi Semadi, Ida Bagus Aditya Nugraha","doi":"10.15562/bmj.v11i3.3910","DOIUrl":"https://doi.org/10.15562/bmj.v11i3.3910","url":null,"abstract":"Background: Obesity is an inflammatory condition that results in an increase in high sensitive C-Reactive Protein (hs-CRP), a risk for insulin resistance (IR). Vaspin has the effect of increasing insulin receptor sensitivity and on the other hand is a compensatory response to insulin resistance, one of which is measured by homeostasis models assessment-insulin resistance (HOMA-IR). This study was an analytical cross-sectional observational design, to determine the association between insulin, glucagon, CRP, and HOMA-IR levels with serum vaspin in obesity.\u0000Method: This study is an analytical study with a cross-sectional design. Criteria of inclusion were subjects in the range 18-60 years Denpasar citizen with BMI above 25 kg/m2 and willing to be involved in this study, while exclusion criteria were with either chronic conditions or acute inflammation such as infection, cancer, tumor, or chronic disease which is altered and threatening life. Correlation tests using spearman analysis.\u0000Results: From 131 obese subjects in this study, there were 72 (55%) men and 59 (45%) women. Median age: 33 (22-57) years, fasting insulin: 8.90 (2.20-74.50) ìIU/mL, glucagon: 48.10 (7.58-293.90) pq/mL, hs-CRP: 1.90 (0.20-9.50) mg/L, HOMA-IR: 2 (0.50-23.15), and vaspin levels: 0.16 (0.04-1.46) ng/mL. There was a significant positive correlation between HOMA-IR, insulin and glucagon with vaspin (r = 0.20, p = 0.020; r = 0.20, p = 0.022; and r = 0.28, p = 0.001), and a significant negative correlation between hs-CRP and vaspin (r = -0.24, p = 0.005) in obesity. In the path analysis, there was a direct and total negative effect of hs-CRP on vaspin (coefficient = -0.19; p = 0.027 and coefficient = -0.02; p = 0.038).\u0000Conclusion: This study shows a positive association between insulin, glucagon, and HOMA-IR with serum vaspin, while CRP is negatively associated with serum vaspin in obesity.","PeriodicalId":44369,"journal":{"name":"Bali Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43628008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Hypertension in adolescents’ risk factors include foods that contain high sodium, lack of physical activity, stress, obesity, alcohol consumption, and smoking. Order to prevent hypertension incidence in adolescents by increasing self-awareness through the provision of health education. This study aimed to determine the health education effect regarding the risk factors of hypertension (stress and sodium diet) on the self-awareness of undergraduate students in Yogyakarta. Methods: This study was a quantitative study with a quasi-experiment pretest & posttest with a control group design. The hypertension self-awareness questionnaire was used in this study and the results will be classified into two groups (the control and the intervention group). The sample obtained in this study was 54 respondents. The Mann-Whitney U and Wilcoxon Signed Rank test was done in this study. Results: It showed that there were significant differences in the intervention group and control group. There were significant differences in results found before and after health education (significance value 0.000), while the result for the control group is 0.06, which indicates that there were no significant differences before and after the leaflet. Conclusions: It can be concluded that health education regarding risk factors for hypertension (stress and a high sodium diet) can increase self-awareness for undergraduate students in Yogyakarta.
{"title":"Intensifying self-awareness of undergraduate students toward hypertension risk factors through health education","authors":"A. Relawati, Dewi Maulidawati","doi":"10.15562/bmj.v11i3.3784","DOIUrl":"https://doi.org/10.15562/bmj.v11i3.3784","url":null,"abstract":"Introduction: Hypertension in adolescents’ risk factors include foods that contain high sodium, lack of physical activity, stress, obesity, alcohol consumption, and smoking. Order to prevent hypertension incidence in adolescents by increasing self-awareness through the provision of health education. This study aimed to determine the health education effect regarding the risk factors of hypertension (stress and sodium diet) on the self-awareness of undergraduate students in Yogyakarta.\u0000Methods: This study was a quantitative study with a quasi-experiment pretest & posttest with a control group design. The hypertension self-awareness questionnaire was used in this study and the results will be classified into two groups (the control and the intervention group). The sample obtained in this study was 54 respondents. The Mann-Whitney U and Wilcoxon Signed Rank test was done in this study.\u0000Results: It showed that there were significant differences in the intervention group and control group. There were significant differences in results found before and after health education (significance value 0.000), while the result for the control group is 0.06, which indicates that there were no significant differences before and after the leaflet.\u0000Conclusions: It can be concluded that health education regarding risk factors for hypertension (stress and a high sodium diet) can increase self-awareness for undergraduate students in Yogyakarta.","PeriodicalId":44369,"journal":{"name":"Bali Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44662380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Uuk Riuh Kusuma Wardana, A. Endaryanto, C. Prakoeswa
Introduction: Skin prick test (SPT) is a method for diagnosing IgE-mediated allergen sensitization. Although the sensitivity and specificity are quite good, false positive and false negative results are possible. The diameter of the wheal and flare of each allergen can affect the skin prick test measurement, especially if the results of the examination overlap. Because of the usage of the SPT and the emphasis on quality control of health services recently, several variables that can affect the results of SPT must be considered. This study aims to analyze the effect of age, gender, family history of allergy, clinical symptoms, and illness duration on SPT's flare diameter. Method: This is a cross-sectional study conducted from 2015 to 2020 in Surabaya, Indonesia. Children with possible allergies were tested with a skin prick test at the allergy immunology outpatient clinic of the Dr. Soetomo General Academic Hospital. Inclusion criteria were ≤ 18 years old children, possibly diagnosed with allergies, who had skin prick test. Children with incomplete medical record data were excluded. The Chi-square test or Fisher exact test to determine the relationship between the independent and dependent variables for nominal data. The p-value was declared significant if P<0.05 to determine the effect between variables on flare diameter on skin prick test. We use SmartPLS to analyse the relationships simultaneously to compare relationships with the regression analysis. Result: Age, gender, clinical symptoms, and duration of illness did not show a significant effect. In contrast, the flare diameter determined by SPT and the presence of an allergic family had a significant correlation (p = 0.017). Therefore, the appropriate distance between allergens must be specified to prevent overlap of SPT flare diameters. Conclusion: Member of family allergy affects the diameter of the flare on skin prick test.
{"title":"The impact of age, gender, family history of allergy, clinical symptoms, and duration of illness on flare diameter of skin prick test","authors":"Uuk Riuh Kusuma Wardana, A. Endaryanto, C. Prakoeswa","doi":"10.15562/bmj.v11i3.3870","DOIUrl":"https://doi.org/10.15562/bmj.v11i3.3870","url":null,"abstract":"Introduction: Skin prick test (SPT) is a method for diagnosing IgE-mediated allergen sensitization. Although the sensitivity and specificity are quite good, false positive and false negative results are possible. The diameter of the wheal and flare of each allergen can affect the skin prick test measurement, especially if the results of the examination overlap. Because of the usage of the SPT and the emphasis on quality control of health services recently, several variables that can affect the results of SPT must be considered. This study aims to analyze the effect of age, gender, family history of allergy, clinical symptoms, and illness duration on SPT's flare diameter.\u0000Method: This is a cross-sectional study conducted from 2015 to 2020 in Surabaya, Indonesia. Children with possible allergies were tested with a skin prick test at the allergy immunology outpatient clinic of the Dr. Soetomo General Academic Hospital. Inclusion criteria were ≤ 18 years old children, possibly diagnosed with allergies, who had skin prick test. Children with incomplete medical record data were excluded. The Chi-square test or Fisher exact test to determine the relationship between the independent and dependent variables for nominal data. The p-value was declared significant if P<0.05 to determine the effect between variables on flare diameter on skin prick test. We use SmartPLS to analyse the relationships simultaneously to compare relationships with the regression analysis.\u0000Result: Age, gender, clinical symptoms, and duration of illness did not show a significant effect. In contrast, the flare diameter determined by SPT and the presence of an allergic family had a significant correlation (p = 0.017). Therefore, the appropriate distance between allergens must be specified to prevent overlap of SPT flare diameters.\u0000Conclusion: Member of family allergy affects the diameter of the flare on skin prick test. ","PeriodicalId":44369,"journal":{"name":"Bali Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41336684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stefanus Satria Adi Dharma, Selamat Budiono, SefriNoventi Sofia
Background: Breast cancer is a malignancy originating from breast tissue, where chemotherapy is one of the choice therapy. Doxorubicin, 5-fluorouracil, and cyclophosphamide (FAC) are the most commonly used combination of chemotherapy. One of the side effects of chemotherapy is cardiotoxicity. Multiflora honey prevents cardiotoxic effects through its flavonoids and polyphenols compounds. The aim of this research is to analyze the effectiveness of adding honey in preventing cardiotoxic effects in breast cancer patients receiving FAC chemotherapy. Methods: An experimental study with double-blind randomized pre and post-test with control group design. Ductal invasive breast cancer patients were divided into 2 groups, the control group, who received FAC chemotherapy (n=18) and the treatment group, who received chemotherapy and 90 ml/day honey consumption for 14 days (n=18). The patient's Troponin I and NT-proBNP enzyme levels before and after 14 days of the study were assessed. Results: Post-treatment, there was an increase in Troponin I levels from the treatment group (0.22 ± 0.07 vs. 0.24 ± 0.07) vs. control (0.25 ± 0.11 vs. 0.34 ± 0.20) with a significant difference. (p = 0.031). There was a decrease in NT-proBNP levels in the treatment group (461.0 ± 610.4 vs. 215.6 ± 260.3) and an increase in NT-proBNP levels (275.9 ± 392.4 vs. 315.4 ± 293.9) with a significant difference (p = 0.006). Conclusion: Multiflora honey can prevent cardiotoxic effects in breast cancer patients receiving FAC chemotherapy.
{"title":"Supplementation in suppressing Troponin I and NT-proBNP level in breast cancer patients with 5- fluorouracil, adriamycin, and cyclophosphamide chemotherapy","authors":"Stefanus Satria Adi Dharma, Selamat Budiono, SefriNoventi Sofia","doi":"10.15562/bmj.v11i3.3596","DOIUrl":"https://doi.org/10.15562/bmj.v11i3.3596","url":null,"abstract":"Background: Breast cancer is a malignancy originating from breast tissue, where chemotherapy is one of the choice therapy. Doxorubicin, 5-fluorouracil, and cyclophosphamide (FAC) are the most commonly used combination of chemotherapy. One of the side effects of chemotherapy is cardiotoxicity. Multiflora honey prevents cardiotoxic effects through its flavonoids and polyphenols compounds. The aim of this research is to analyze the effectiveness of adding honey in preventing cardiotoxic effects in breast cancer patients receiving FAC chemotherapy.\u0000Methods: An experimental study with double-blind randomized pre and post-test with control group design. Ductal invasive breast cancer patients were divided into 2 groups, the control group, who received FAC chemotherapy (n=18) and the treatment group, who received chemotherapy and 90 ml/day honey consumption for 14 days (n=18). The patient's Troponin I and NT-proBNP enzyme levels before and after 14 days of the study were assessed.\u0000Results: Post-treatment, there was an increase in Troponin I levels from the treatment group (0.22 ± 0.07 vs. 0.24 ± 0.07) vs. control (0.25 ± 0.11 vs. 0.34 ± 0.20) with a significant difference. (p = 0.031). There was a decrease in NT-proBNP levels in the treatment group (461.0 ± 610.4 vs. 215.6 ± 260.3) and an increase in NT-proBNP levels (275.9 ± 392.4 vs. 315.4 ± 293.9) with a significant difference (p = 0.006).\u0000Conclusion: Multiflora honey can prevent cardiotoxic effects in breast cancer patients receiving FAC chemotherapy.","PeriodicalId":44369,"journal":{"name":"Bali Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41876767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siti Riptifah Tri Handari, Anies, Martha Irene Kartasurya, Sri Achadi Nugraheni
Introduction: Low hemoglobin levels in pregnant women are global health problem that adversely affect the mother’s and newborn’s health. There is no study proving the effect of anemia during adolescence in pregnancy, especially in Indonesian population. This study aimed to investigate the effect of anemia in adolescence on the hemoglobin level during pregnancy, using Indonesian Family Life Survey (IFLS) data. Methods: This retrospective cohort study used the 1997, 2007 and 2014 IFLS data. The hemoglobin levels in adolescents aged 10-18 years were obtained from the IFLS-II data in 1997. Then, the hemoglobin levels during pregnancy from the same individuals were tracked from the IFLS-IV in 2007 and IFLS-V in 2014. Data from 210 subjects were included in the analysis as these subjects had the complete data on hemoglobin levels during adolescence and pregnancy and all other considered confounding variables, such as maternal age, iron protein, vitamin C consumption, education, working status, residence, socioeconomic status, gestational age at data collection, parity, antenatal care, iron supplement consumption. Data was analyzed by T tests, Pearson’s correlation tests and General Linear Model. Results: The mean hemoglobin levels of pregnant women was 11.23 g/dL with standard deviation 1.271 and the prevalence of anemia during adolescence was 34.3%. There was a significant difference of 0.447 g/dL in the average hemoglobin levels in pregnant women with and without history of anemia during adolescence (p=0.023). The hemoglobin levels in pregnant women also differed among trimesters of gestational age (p=0.001). After being controlled for vitamin C and protein consumption, anemia status during adolescence still has a significant effect on lowering hemoglobin level during pregnancy. Conclusion: Anemia during adolescence negatively impacts pregnant women's hemoglobin levels. Prevention programs for anemia in pregnant women should be started from adolescence period.
{"title":"Haemoglobin Level of Pregnant Women was Associated with History of Anemia During Adolescent Period: Findings from the Indonesia Family Life Survey","authors":"Siti Riptifah Tri Handari, Anies, Martha Irene Kartasurya, Sri Achadi Nugraheni","doi":"10.15562/bmj.v11i3.3783","DOIUrl":"https://doi.org/10.15562/bmj.v11i3.3783","url":null,"abstract":"Introduction: Low hemoglobin levels in pregnant women are global health problem that adversely affect the mother’s and newborn’s health. There is no study proving the effect of anemia during adolescence in pregnancy, especially in Indonesian population. This study aimed to investigate the effect of anemia in adolescence on the hemoglobin level during pregnancy, using Indonesian Family Life Survey (IFLS) data.\u0000Methods: This retrospective cohort study used the 1997, 2007 and 2014 IFLS data. The hemoglobin levels in adolescents aged 10-18 years were obtained from the IFLS-II data in 1997. Then, the hemoglobin levels during pregnancy from the same individuals were tracked from the IFLS-IV in 2007 and IFLS-V in 2014. Data from 210 subjects were included in the analysis as these subjects had the complete data on hemoglobin levels during adolescence and pregnancy and all other considered confounding variables, such as maternal age, iron protein, vitamin C consumption, education, working status, residence, socioeconomic status, gestational age at data collection, parity, antenatal care, iron supplement consumption. Data was analyzed by T tests, Pearson’s correlation tests and General Linear Model.\u0000Results: The mean hemoglobin levels of pregnant women was 11.23 g/dL with standard deviation 1.271 and the prevalence of anemia during adolescence was 34.3%. There was a significant difference of 0.447 g/dL in the average hemoglobin levels in pregnant women with and without history of anemia during adolescence (p=0.023). The hemoglobin levels in pregnant women also differed among trimesters of gestational age (p=0.001). After being controlled for vitamin C and protein consumption, anemia status during adolescence still has a significant effect on lowering hemoglobin level during pregnancy.\u0000Conclusion: Anemia during adolescence negatively impacts pregnant women's hemoglobin levels. Prevention programs for anemia in pregnant women should be started from adolescence period.","PeriodicalId":44369,"journal":{"name":"Bali Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47964084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Machmudah, E. Yunitasari, Mira Triharini, Sri Rejeki
Background: Breast milk plays a role in cognitive, sensory, and motor development and protects against infections and chronic diseases. The process of breastfeeding will protect the baby from illness, and increase cognitive intelligence and social-emotional development between mother and baby. Duration of breastfeeding was associated with acute illnesses, diarrhea, constipation, and a lower likelihood of being overweight/obese. Thus, this study aimed to the investigated correlation between pregnancy status and delivery type with successful breastfeeding in postpartum mothers at Roemani Muhammadiyah Hospital Semarang Methods: This type of research was analytical descriptive, conducted in December 2021 with purposive sampling and a sample size of 120 respondents. The inclusion criteria of postpartum mothers who breastfeed their babies, mothers who are in good health, and baby who has no congenital abnormalities. Respondents who refused and who have babies with congenital abnormalities are excluded from the study. The data was extracted from the questionnaire and also coded into the SPSS 25 ver. Data were analyzed descriptively and analytically by using chi-square analysis. Results: The participant with a planned pregnancy was 107 mothers (89.2%), unplanned 13 mothers (10,8%), section Caesarea type of delivery was 70 mothers (52%) and vaginal type of delivery was 50 mothers (48%). Based on LATCH score analysis planned pregnancy showed good category 38 mothers (31,7%), medium category 69 mothers (57,5%), and planned pregnancy showed good category 4 mothers (3,4%), medium category 8 mothers (6,7%), bad category 1 mother (0,8%). Based on the type of delivery, the vaginal type score was good for 25 mothers (50%), medium for 25 mothers (25%), and the section Caesarea type score was good for 17 mothers (24%), medium for 52 mothers (75%) and bad 1 mothers (1%). Either pregnancy status and type of delivery have P value scores of 0,016 and 0,012, respectively. Conclusion: A mother that delivers a vaginal has a better level of breastfeeding than SC, and pregnancy status such as planned pregnancy also shows a better level than they are not.
{"title":"The description of pregnancy status and type of delivery attachment technique in postpartum mothers at the Roemani muhammadiyah hospital Semarang: assessed by latch score analysis","authors":"Machmudah, E. Yunitasari, Mira Triharini, Sri Rejeki","doi":"10.15562/bmj.v11i3.3752","DOIUrl":"https://doi.org/10.15562/bmj.v11i3.3752","url":null,"abstract":"Background: Breast milk plays a role in cognitive, sensory, and motor development and protects against infections and chronic diseases. The process of breastfeeding will protect the baby from illness, and increase cognitive intelligence and social-emotional development between mother and baby. Duration of breastfeeding was associated with acute illnesses, diarrhea, constipation, and a lower likelihood of being overweight/obese. Thus, this study aimed to the investigated correlation between pregnancy status and delivery type with successful breastfeeding in postpartum mothers at Roemani Muhammadiyah Hospital Semarang\u0000Methods: This type of research was analytical descriptive, conducted in December 2021 with purposive sampling and a sample size of 120 respondents. The inclusion criteria of postpartum mothers who breastfeed their babies, mothers who are in good health, and baby who has no congenital abnormalities. Respondents who refused and who have babies with congenital abnormalities are excluded from the study. The data was extracted from the questionnaire and also coded into the SPSS 25 ver. Data were analyzed descriptively and analytically by using chi-square analysis.\u0000Results: The participant with a planned pregnancy was 107 mothers (89.2%), unplanned 13 mothers (10,8%), section Caesarea type of delivery was 70 mothers (52%) and vaginal type of delivery was 50 mothers (48%). Based on LATCH score analysis planned pregnancy showed good category 38 mothers (31,7%), medium category 69 mothers (57,5%), and planned pregnancy showed good category 4 mothers (3,4%), medium category 8 mothers (6,7%), bad category 1 mother (0,8%). Based on the type of delivery, the vaginal type score was good for 25 mothers (50%), medium for 25 mothers (25%), and the section Caesarea type score was good for 17 mothers (24%), medium for 52 mothers (75%) and bad 1 mothers (1%). Either pregnancy status and type of delivery have P value scores of 0,016 and 0,012, respectively.\u0000Conclusion: A mother that delivers a vaginal has a better level of breastfeeding than SC, and pregnancy status such as planned pregnancy also shows a better level than they are not.","PeriodicalId":44369,"journal":{"name":"Bali Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45535855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Rejeki, Eka Agustyaningrum, Macmudah, N. Khayati, Tri Hartiti, Dwinda Safitri, Yanuan Ben Olina
Introduction: Chemotherapy is one of the management applied to cervical cancer patients. Chemotherapy is beneficial to kill cancer cells, but it affects normal body cells, such as hair roots, skin, and changes in physical appearance. These physical changes result in poor self-assessment and stress. This study was conducted to describe the correlation between body image and stress level of cervical cancer patients undergoing chemotherapy at the Gynecology Polyclinic, Dr. Kariadi General Hospital Medical Center Semarang. Methods: This type of research is quantitative using a correlational research design. The research process was carried out in 2020 at Dr. Kariadi General Hospital Medical Center Semarang with the number of samples obtained was 87 respondents. Results: It showed that there was a relationship between body image and stress levels in cervical cancer patients receiving chemotherapy (r = -0.313 and p-value = 0.003). With a change in physical appearance, patients would feel something different which affects psychological situations and further causes stress. Conclusions: The level of stress has a significant correlation with the body image score of cervical cancer.
{"title":"Body image and the level of stress in cervical cancer patients","authors":"S. Rejeki, Eka Agustyaningrum, Macmudah, N. Khayati, Tri Hartiti, Dwinda Safitri, Yanuan Ben Olina","doi":"10.15562/bmj.v11i3.3769","DOIUrl":"https://doi.org/10.15562/bmj.v11i3.3769","url":null,"abstract":"Introduction: Chemotherapy is one of the management applied to cervical cancer patients. Chemotherapy is beneficial to kill cancer cells, but it affects normal body cells, such as hair roots, skin, and changes in physical appearance. These physical changes result in poor self-assessment and stress. This study was conducted to describe the correlation between body image and stress level of cervical cancer patients undergoing chemotherapy at the Gynecology Polyclinic, Dr. Kariadi General Hospital Medical Center Semarang.\u0000Methods: This type of research is quantitative using a correlational research design. The research process was carried out in 2020 at Dr. Kariadi General Hospital Medical Center Semarang with the number of samples obtained was 87 respondents.\u0000Results: It showed that there was a relationship between body image and stress levels in cervical cancer patients receiving chemotherapy (r = -0.313 and p-value = 0.003). With a change in physical appearance, patients would feel something different which affects psychological situations and further causes stress.\u0000Conclusions: The level of stress has a significant correlation with the body image score of cervical cancer.","PeriodicalId":44369,"journal":{"name":"Bali Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48014340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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