首页 > 最新文献

Annals of Joint最新文献

英文 中文
Surgical outcomes of non-periprosthetic distal femur fragility fractures treated with a locking plate. 锁定钢板治疗非假体周围股骨远端脆性骨折的手术疗效
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2022-10-15 eCollection Date: 2022-01-01 DOI: 10.21037/aoj-22-15
Jiayong Liu, David Hein, Christopher Huffman, Brian M Rao, Jonathan Cooper, Nabil A Ebraheim

Background: Management of distal femur fractures can be challenging, particularly in the aged female population. This retrospective study aims to analyze the surgical outcomes of aged female patients with non-periprosthetic distal femur fractures treated with a locking plate.

Methods: This is an IRB approved retrospective review conducted at a level 1 trauma center. Fifty-five female patients (mean age of 71 years) with non-periprosthetic distal femur fractures underwent open reduction internal fixation using a locking plate from 2005 to 2019. The average follow-up time was 67 weeks from the date of injury. Criteria used for diagnosis of nonunion included one or more of the following: (I) three consecutive months without progression of healing on postoperative radiographs, (II) a total of nine months postoperative without complete healing, or (III) the physician diagnosed nonunion using clinical judgement. Outcome data was analyzed and compared amongst patients with and without obesity or diabetes. Statistical analysis was performed utilizing Microsoft Excel 2022 Data Analysis ToolPak with a standard statistically significant P value of <0.05.

Results: Thirty-two patients (58%) with distal femur fractures achieved union after initial treatment while 23 patients (42%) were diagnosed with nonunion. Fourteen patients (61%) underwent revision with 9 of these patients (64%) achieving union while 5 patients (36%) had persistent nonunion. Average healing time from initial treatment to union was 29 weeks, while average time from definitive treatment to union was 22 weeks. Obese patients [body mass index (BMI) >30 kg/m2] had a nonunion rate of 65%, while non-obese patients had a nonunion rate of 28%. Patients with diabetes had a nonunion rate of 65%, while patients without diabetes had a nonunion rate of 28%.

Conclusions: Union can be successfully achieved in aged female patients with distal femur fractures treated with locking plates; however, the risks for nonunion and revision remain high. Patients with obesity and diabetes appear to be at an increased risk of nonunion (P=0.008 and 0.008, respectively). However, further research should be conducted with a prospective study or multivariate analysis and increased number of patients to reaffirm this data.

背景:股骨远端骨折的治疗具有挑战性,尤其是在老年女性人群中。本回顾性研究旨在分析使用锁定钢板治疗非假体股骨远端骨折的老年女性患者的手术效果:方法:这是一项经 IRB 批准的回顾性研究,在一家一级创伤中心进行。从2005年到2019年,55名非假体股骨远端骨折的女性患者(平均年龄71岁)接受了使用锁定钢板的切开复位内固定术。平均随访时间为自受伤之日起 67 周。诊断股骨不愈合的标准包括以下一项或多项:(I)术后连续三个月X光片无愈合进展,(II)术后共九个月未完全愈合,或(III)医生根据临床判断诊断为骨不连。对结果数据进行了分析,并在有肥胖症或糖尿病的患者和没有肥胖症或糖尿病的患者之间进行了比较。统计分析使用 Microsoft Excel 2022 数据分析工具包进行,标准统计学意义的 P 值为 结果:32名股骨远端骨折患者(58%)在初次治疗后实现了骨折愈合,23名患者(42%)被诊断为骨折不愈合。14名患者(61%)接受了翻修,其中9名患者(64%)实现了骨折愈合,5名患者(36%)出现了持续性不愈合。从初次治疗到骨结合的平均愈合时间为 29 周,而从最终治疗到骨结合的平均时间为 22 周。肥胖患者[体重指数(BMI)>30 kg/m2]的不愈合率为65%,而非肥胖患者的不愈合率为28%。糖尿病患者的不愈合率为 65%,而非糖尿病患者的不愈合率为 28%:结论:使用锁定钢板治疗股骨远端骨折的老年女性患者可成功实现骨折愈合,但发生骨折不愈合和翻修的风险仍然很高。肥胖和糖尿病患者发生骨折不愈合的风险似乎更高(P=0.008 和 0.008)。不过,应通过前瞻性研究或多变量分析以及增加患者人数来进一步证实这一数据。
{"title":"Surgical outcomes of non-periprosthetic distal femur fragility fractures treated with a locking plate.","authors":"Jiayong Liu, David Hein, Christopher Huffman, Brian M Rao, Jonathan Cooper, Nabil A Ebraheim","doi":"10.21037/aoj-22-15","DOIUrl":"10.21037/aoj-22-15","url":null,"abstract":"<p><strong>Background: </strong>Management of distal femur fractures can be challenging, particularly in the aged female population. This retrospective study aims to analyze the surgical outcomes of aged female patients with non-periprosthetic distal femur fractures treated with a locking plate.</p><p><strong>Methods: </strong>This is an IRB approved retrospective review conducted at a level 1 trauma center. Fifty-five female patients (mean age of 71 years) with non-periprosthetic distal femur fractures underwent open reduction internal fixation using a locking plate from 2005 to 2019. The average follow-up time was 67 weeks from the date of injury. Criteria used for diagnosis of nonunion included one or more of the following: (I) three consecutive months without progression of healing on postoperative radiographs, (II) a total of nine months postoperative without complete healing, or (III) the physician diagnosed nonunion using clinical judgement. Outcome data was analyzed and compared amongst patients with and without obesity or diabetes. Statistical analysis was performed utilizing Microsoft Excel 2022 Data Analysis ToolPak with a standard statistically significant P value of <0.05.</p><p><strong>Results: </strong>Thirty-two patients (58%) with distal femur fractures achieved union after initial treatment while 23 patients (42%) were diagnosed with nonunion. Fourteen patients (61%) underwent revision with 9 of these patients (64%) achieving union while 5 patients (36%) had persistent nonunion. Average healing time from initial treatment to union was 29 weeks, while average time from definitive treatment to union was 22 weeks. Obese patients [body mass index (BMI) >30 kg/m<sup>2</sup>] had a nonunion rate of 65%, while non-obese patients had a nonunion rate of 28%. Patients with diabetes had a nonunion rate of 65%, while patients without diabetes had a nonunion rate of 28%.</p><p><strong>Conclusions: </strong>Union can be successfully achieved in aged female patients with distal femur fractures treated with locking plates; however, the risks for nonunion and revision remain high. Patients with obesity and diabetes appear to be at an increased risk of nonunion (P=0.008 and 0.008, respectively). However, further research should be conducted with a prospective study or multivariate analysis and increased number of patients to reaffirm this data.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"1 1","pages":"32"},"PeriodicalIF":0.4,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42490776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inter- and intra-rater reliability of knee flexion angle measurements on X-ray and MRI. X 射线和核磁共振成像膝关节屈曲角度测量的评分者之间和评分者内部的可靠性。
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2022-10-15 eCollection Date: 2022-01-01 DOI: 10.21037/aoj-22-2
Harry Kyle Campbell Summers, Stephen Picken, Oday Al-Dadah

Background: Range of motion (ROM) is an important aspect of orthopaedic patient assessment. It can be measured at the knee joint by determining the knee flexion angle (KFA) a patient can achieve at extremes of flexion and extension. As with any measurement, the accuracy and reliability of the method used determine its validity. The consistency of magnetic resonance imaging (MRI) scans as compared to the current gold standard of X-ray remains unknown in terms of KFA evaluation. The aim of this study was to assess and compare the reliability of measuring KFA between X-ray and MRI scans.

Methods: This study included 80 patients (94 knees) who had attended a specialist knee clinic due to varying knee pathologies and undergone both X-ray and MRI scans. Lateral and T1-weighted sagittal imaging views (respectively) were used to measure KFA by two trained observers independently at two separate time points, 8 weeks apart. The data was then statistically analysed and intra- and inter-observer reliability calculated using the intraclass correlation coefficient (ICC).

Results: The intra-observer reliability for X-ray was 0.96 (P<0.001) and that for MRI was 0.83 (P<0.001). The inter-observer reliability for X-ray was 0.99 (P<0.001) and that for MRI was 0.81 (P<0.001). All the intra-class correlation coefficients were graded as excellent in both the intra- and inter-observer reliability analysis. Overall, the mean KFA was notably higher on X-ray measurements than that on MRI scans. There was a statistically significant difference between Time 1 and Time 2 measurements (17.7° vs. 16.8°) for MRI data (P=0.022). No significant difference was found for X-ray measurements (46.4° vs. 45.6°) in this regard (P=0.182).

Conclusions: Both X-ray and MRI allow KFA to be measured with an excellent degree of reliability. However, X-ray measurements were overall superior to that of MRI mainly due to the larger field of view of the visible on-screen image which more readily identifies the anatomical landmarks required to measure KFA.

背景:活动范围(ROM)是骨科患者评估的一个重要方面。它可以通过确定患者在屈伸极限时所能达到的膝关节屈曲角(KFA)来测量膝关节的活动范围。与任何测量一样,所用方法的准确性和可靠性决定了其有效性。就 KFA 评估而言,磁共振成像(MRI)扫描与目前的黄金标准 X 光片相比,其一致性仍是未知数。本研究旨在评估和比较 X 光和核磁共振成像扫描测量 KFA 的可靠性:这项研究包括 80 名患者(94 个膝关节),他们因不同的膝关节病变前往膝关节专科门诊就诊,并接受了 X 光和核磁共振成像扫描。由两名训练有素的观察者分别在两个不同的时间点(相隔 8 周)测量侧位和 T1 加权矢状位成像视图(分别)的 KFA。然后对数据进行统计分析,并使用类内相关系数(ICC)计算观察者内部和观察者之间的可靠性:结果:X 射线的观察者内可靠性为 0.96(Pvs.16.8°),磁共振成像数据的观察者内可靠性为 0.96(P=0.022)。在这方面,X 光测量结果(46.4° 对 45.6°)无明显差异(P=0.182):结论:X 射线和磁共振成像都能以极高的可靠性测量 KFA。结论:X 射线和磁共振成像都能以极高的可靠性测量 KFA,但总体而言,X 射线测量优于磁共振成像测量,这主要是因为屏幕上可见图像的视野更大,更容易识别测量 KFA 所需的解剖标志。
{"title":"Inter- and intra-rater reliability of knee flexion angle measurements on X-ray and MRI.","authors":"Harry Kyle Campbell Summers, Stephen Picken, Oday Al-Dadah","doi":"10.21037/aoj-22-2","DOIUrl":"10.21037/aoj-22-2","url":null,"abstract":"<p><strong>Background: </strong>Range of motion (ROM) is an important aspect of orthopaedic patient assessment. It can be measured at the knee joint by determining the knee flexion angle (KFA) a patient can achieve at extremes of flexion and extension. As with any measurement, the accuracy and reliability of the method used determine its validity. The consistency of magnetic resonance imaging (MRI) scans as compared to the current gold standard of X-ray remains unknown in terms of KFA evaluation. The aim of this study was to assess and compare the reliability of measuring KFA between X-ray and MRI scans.</p><p><strong>Methods: </strong>This study included 80 patients (94 knees) who had attended a specialist knee clinic due to varying knee pathologies and undergone both X-ray and MRI scans. Lateral and T1-weighted sagittal imaging views (respectively) were used to measure KFA by two trained observers independently at two separate time points, 8 weeks apart. The data was then statistically analysed and intra- and inter-observer reliability calculated using the intraclass correlation coefficient (ICC).</p><p><strong>Results: </strong>The intra-observer reliability for X-ray was 0.96 (P<0.001) and that for MRI was 0.83 (P<0.001). The inter-observer reliability for X-ray was 0.99 (P<0.001) and that for MRI was 0.81 (P<0.001). All the intra-class correlation coefficients were graded as excellent in both the intra- and inter-observer reliability analysis. Overall, the mean KFA was notably higher on X-ray measurements than that on MRI scans. There was a statistically significant difference between Time 1 and Time 2 measurements (17.7° <i>vs.</i> 16.8°) for MRI data (P=0.022). No significant difference was found for X-ray measurements (46.4° <i>vs.</i> 45.6°) in this regard (P=0.182).</p><p><strong>Conclusions: </strong>Both X-ray and MRI allow KFA to be measured with an excellent degree of reliability. However, X-ray measurements were overall superior to that of MRI mainly due to the larger field of view of the visible on-screen image which more readily identifies the anatomical landmarks required to measure KFA.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"7 ","pages":"34"},"PeriodicalIF":0.4,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Massive pseudotumor of unknown etiology in a cemented metal-on-polyethylene total hip arthroplasty: a case report. 病因不明的骨水泥聚乙烯金属全髋关节置换术大面积假瘤:病例报告。
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2022-10-15 eCollection Date: 2022-01-01 DOI: 10.21037/aoj-22-3
Aaron Gazendam, Karim Masrouha, Snezana Popovic, Michelle Ghert, David Wilson

Background: The formation of destructive pseudotumors is a well-documented, albeit rare, complication of total hip arthroplasties. They tend to be progressive and, if left untreated, can result in extensive periprosthetic bony destruction. The current case presents a large benign mass consistent with a pseudotumor on both imaging and intraoperative findings but histologic findings demonstrating chronic hematoma.

Case description: An 86-year-old female with a metal-on-polyethylene total hip presented with a massive pseudotumor accompanied by extensive bony lysis. Due to pain and chronic anemia, a palliative debulking procedure was undertaken as a palliative measure. At one year follow-up, the patient reported significant pain relief and was able to ambulate safely with gait aids. Her hemoglobin stabilized post-operatively and ongoing transfusions were not required. Final pathology was not supportive of particle disease despite this being the leading diagnosis. Microscopic sections showed tissue mostly composed of fibrin and blood with multiple foci of calcification and reactive papillary endothelial hyperplasia which can be seen in chronic hematomas.

Conclusions: This case presents the diagnostic dilemma of a large benign mass consistent with a pseudotumor on both imaging and intraoperative findings but histologic findings consistent with a chronic hematoma. It highlights the importance of close follow-up and early intervention when periprosthetic osteolysis is detected.

背景:破坏性假瘤的形成是全髋关节置换术的一种并发症,尽管罕见,但已得到充分证实。假瘤往往呈进行性发展,如果不及时治疗,可导致假体周围大面积骨质破坏。本病例中的大块良性肿块在影像学和术中发现均与假瘤一致,但组织学结果显示为慢性血肿:一位86岁的女性患者,其髋关节为金属聚乙烯全髋关节,并伴有巨大的假瘤和广泛的骨质溶解。由于疼痛和慢性贫血,患者接受了姑息性剥脱手术。在一年的随访中,患者表示疼痛明显缓解,并能在步态辅助工具的帮助下安全行走。术后她的血红蛋白趋于稳定,无需继续输血。最终病理结果不支持颗粒疾病,尽管这是主要诊断。显微镜切片显示组织主要由纤维蛋白和血液组成,并伴有多个钙化灶和反应性乳头状内皮增生,这在慢性血肿中很常见:本病例的影像学和术中检查结果均符合假瘤,但组织学检查结果却与慢性血肿一致,这是一个巨大良性肿块的诊断难题。它强调了在发现假体周围溶骨时密切随访和早期干预的重要性。
{"title":"Massive pseudotumor of unknown etiology in a cemented metal-on-polyethylene total hip arthroplasty: a case report.","authors":"Aaron Gazendam, Karim Masrouha, Snezana Popovic, Michelle Ghert, David Wilson","doi":"10.21037/aoj-22-3","DOIUrl":"10.21037/aoj-22-3","url":null,"abstract":"<p><strong>Background: </strong>The formation of destructive pseudotumors is a well-documented, albeit rare, complication of total hip arthroplasties. They tend to be progressive and, if left untreated, can result in extensive periprosthetic bony destruction. The current case presents a large benign mass consistent with a pseudotumor on both imaging and intraoperative findings but histologic findings demonstrating chronic hematoma.</p><p><strong>Case description: </strong>An 86-year-old female with a metal-on-polyethylene total hip presented with a massive pseudotumor accompanied by extensive bony lysis. Due to pain and chronic anemia, a palliative debulking procedure was undertaken as a palliative measure. At one year follow-up, the patient reported significant pain relief and was able to ambulate safely with gait aids. Her hemoglobin stabilized post-operatively and ongoing transfusions were not required. Final pathology was not supportive of particle disease despite this being the leading diagnosis. Microscopic sections showed tissue mostly composed of fibrin and blood with multiple foci of calcification and reactive papillary endothelial hyperplasia which can be seen in chronic hematomas.</p><p><strong>Conclusions: </strong>This case presents the diagnostic dilemma of a large benign mass consistent with a pseudotumor on both imaging and intraoperative findings but histologic findings consistent with a chronic hematoma. It highlights the importance of close follow-up and early intervention when periprosthetic osteolysis is detected.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"7 ","pages":"40"},"PeriodicalIF":0.4,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A narrative review of lateral meniscus transplantation with the bridge in slot: technique and outcomes. 使用槽桥进行外侧半月板移植的叙述性综述:技术和结果。
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2022-04-15 eCollection Date: 2022-01-01 DOI: 10.21037/aoj-20-109
Levy I Nathan, Benjamin S Kester, Nolan B Condron, Aghogho Evuarherhe, Brain J Cole

Objective: This narrative review aims to detail the indications, technique, and published outcomes of the bridge in slot technique for lateral meniscus allograft transplantation (LMAT) and to serve as a concise reference for orthopaedists looking to incorporate this method into their practice.

Background: The menisci are crucial to normal knee function but are commonly injured; partial and subtotal meniscectomy are frequently performed to address meniscal pathology. Following these procedures, a substantial number of patients go on to develop degenerative joint changes accompanied by pain and disability. LMAT is an attractive option for young, active, lateral meniscal-deficient patients who seek pain relief and improved function but who are not yet prepared to undergo arthroplasty. In the properly indicated patient, the bridge in slot technique is a reliable and effective method for LMAT.

Methods: Using a narrative style, this review outlines the indications and preoperative assessment for LMAT, the detailed technical steps for the bridge in slot technique, postoperative considerations, and trends in the surgical outcomes literature. The presented technique is consistent with the senior author's clinical experience and with published literature and the discussed outcomes are elicited from a focused review of recent peer-reviewed sources.

Conclusions: The bridge in slot technique is a reliable and effective method for LMAT and is supported by the literature. This technique may confidently be used in patients with severe lateral meniscal pathology who are not yet candidates for arthroplasty.

目的:这篇叙述性综述旨在详细介绍外侧半月板同种异体移植(LMAT)的适应症、技术和已发表的结果,并为希望将这种方法纳入其临床实践的骨科医生提供简明参考:背景:半月板对膝关节的正常功能至关重要,但却经常受到损伤;为解决半月板病理问题,经常会进行半月板部分切除术和半月板次全切除术。这些手术后,相当多的患者会出现关节退行性病变,并伴有疼痛和残疾。对于年轻、活跃、有外侧半月板缺损的患者来说,LMAT 是一个很有吸引力的选择,因为他们需要缓解疼痛、改善功能,但还没有准备好接受关节成形术。对于有适当适应症的患者,槽桥技术是一种可靠有效的 LMAT 方法:本综述采用叙述的方式,概述了 LMAT 的适应症和术前评估、槽中桥技术的详细技术步骤、术后注意事项以及手术效果文献的趋势。所介绍的技术与资深作者的临床经验和已发表的文献一致,所讨论的结果是通过对近期同行评议资料的重点回顾得出的:槽中桥技术是一种可靠、有效的 LMAT 方法,并得到了文献的支持。结论:槽中桥技术是一种可靠、有效的LMAT方法,并得到了相关文献的支持。对于患有严重外侧半月板病变但尚未进行关节置换术的患者,可以放心地使用这种技术。
{"title":"A narrative review of lateral meniscus transplantation with the bridge in slot: technique and outcomes.","authors":"Levy I Nathan, Benjamin S Kester, Nolan B Condron, Aghogho Evuarherhe, Brain J Cole","doi":"10.21037/aoj-20-109","DOIUrl":"10.21037/aoj-20-109","url":null,"abstract":"<p><strong>Objective: </strong>This narrative review aims to detail the indications, technique, and published outcomes of the bridge in slot technique for lateral meniscus allograft transplantation (LMAT) and to serve as a concise reference for orthopaedists looking to incorporate this method into their practice.</p><p><strong>Background: </strong>The menisci are crucial to normal knee function but are commonly injured; partial and subtotal meniscectomy are frequently performed to address meniscal pathology. Following these procedures, a substantial number of patients go on to develop degenerative joint changes accompanied by pain and disability. LMAT is an attractive option for young, active, lateral meniscal-deficient patients who seek pain relief and improved function but who are not yet prepared to undergo arthroplasty. In the properly indicated patient, the bridge in slot technique is a reliable and effective method for LMAT.</p><p><strong>Methods: </strong>Using a narrative style, this review outlines the indications and preoperative assessment for LMAT, the detailed technical steps for the bridge in slot technique, postoperative considerations, and trends in the surgical outcomes literature. The presented technique is consistent with the senior author's clinical experience and with published literature and the discussed outcomes are elicited from a focused review of recent peer-reviewed sources.</p><p><strong>Conclusions: </strong>The bridge in slot technique is a reliable and effective method for LMAT and is supported by the literature. This technique may confidently be used in patients with severe lateral meniscal pathology who are not yet candidates for arthroplasty.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"1 1","pages":"17"},"PeriodicalIF":0.4,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68296930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anterior cruciate ligament injury prevention. 预防前十字韧带损伤。
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2022-01-15 eCollection Date: 2022-01-01 DOI: 10.21037/aoj-2020-01
Hannah Bradsell, Rachel M Frank

Anterior cruciate ligament injuries are a prominent issue in the field of sports medicine, especially for the female athlete. Extensive research has been performed that acknowledges the disparity in anterior cruciate ligament injury rates between male and female athletes and the high prevalence of risk factors specific to females. The underlying causes of anterior cruciate ligament injuries are widespread and are important to consider when approaching injury prevention. For example, prevention techniques aim to correct neuromuscular imbalances and improve biomechanical deficits, which are some of the most significant risk factors leading to these injuries. While there is a lack of opportunity for intervention related to anatomical and hormonal risks, awareness of their influence on injury mechanisms remains an important factor in clinical decision-making. In pursuit of addressing the risks of this injury, several prevention programs have been established that have been shown to successfully reduce anterior cruciate ligament injury rates when properly executed. The most effective programs include early intervention with continuous training and are multicomponent programs including various targeted exercises to modify associated risk factors. Unfortunately, despite the development of these readily available programs, anterior cruciate ligament injury rates remain high due to insufficient implementation of these methods. Recognizing the efficacy and feasibility of utilizing prevention strategies and continuing to develop effective techniques remain of utmost importance to reduce the incidence of this substantial injury among athletes.

前十字韧带损伤是运动医学领域的一个突出问题,尤其是对女运动员而言。大量研究表明,男女运动员的前十字韧带损伤率存在差异,女性特有的风险因素也很普遍。前十字韧带损伤的根本原因十分广泛,在预防损伤时必须加以考虑。例如,预防技术旨在纠正神经肌肉失衡和改善生物力学缺陷,这些都是导致这些损伤的一些最重要的风险因素。虽然缺乏对解剖学和荷尔蒙风险进行干预的机会,但认识到它们对损伤机制的影响仍然是临床决策的一个重要因素。为了应对这种损伤的风险,已经制定了几项预防计划,只要执行得当,这些计划都能成功降低前十字韧带损伤率。最有效的计划包括早期干预和持续训练,并且是多成分计划,包括各种有针对性的练习,以改变相关的风险因素。遗憾的是,尽管制定了这些现成的计划,但由于这些方法实施不足,前十字韧带损伤率仍然居高不下。认识到利用预防策略的有效性和可行性,并继续开发有效的技术,对于降低运动员中这一重大损伤的发生率仍然至关重要。
{"title":"Anterior cruciate ligament injury prevention.","authors":"Hannah Bradsell, Rachel M Frank","doi":"10.21037/aoj-2020-01","DOIUrl":"10.21037/aoj-2020-01","url":null,"abstract":"<p><p>Anterior cruciate ligament injuries are a prominent issue in the field of sports medicine, especially for the female athlete. Extensive research has been performed that acknowledges the disparity in anterior cruciate ligament injury rates between male and female athletes and the high prevalence of risk factors specific to females. The underlying causes of anterior cruciate ligament injuries are widespread and are important to consider when approaching injury prevention. For example, prevention techniques aim to correct neuromuscular imbalances and improve biomechanical deficits, which are some of the most significant risk factors leading to these injuries. While there is a lack of opportunity for intervention related to anatomical and hormonal risks, awareness of their influence on injury mechanisms remains an important factor in clinical decision-making. In pursuit of addressing the risks of this injury, several prevention programs have been established that have been shown to successfully reduce anterior cruciate ligament injury rates when properly executed. The most effective programs include early intervention with continuous training and are multicomponent programs including various targeted exercises to modify associated risk factors. Unfortunately, despite the development of these readily available programs, anterior cruciate ligament injury rates remain high due to insufficient implementation of these methods. Recognizing the efficacy and feasibility of utilizing prevention strategies and continuing to develop effective techniques remain of utmost importance to reduce the incidence of this substantial injury among athletes.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"7 ","pages":"1"},"PeriodicalIF":0.4,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation and management of patellar instability. 髌骨不稳的评估和治疗。
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2022-01-15 eCollection Date: 2022-01-01 DOI: 10.21037/aoj-2020-02
Elizabeth R Dennis, Simone Gruber, William A Marmor, Beth E Shubin Stein

Patellar instability is a common clinical problem that primarily affects the adolescent and young adult population. The demographic and anatomic risk factors that predispose patients to patellar instability are multifactorial and include young age, female sex, trochlear dysplasia, elevated tibial tubercle to trochlear groove distance (TT-TG), patella alta, femoral and tibial malalignment, ligamentous laxity, and lack of neuromuscular control. There have been substantial efforts to predict which patients who sustain a first-time dislocation will go on to incur additional dislocations. This is particularly important because with each dislocation event, there is a significant risk of injury to the patellofemoral joint including both medial patellofemoral ligament (MPFL) stretch or rupture and damage to the cartilage which can range from simple fissures to full-thickness cartilage defects and osteochondral fractures. Prediction models have demonstrated that amongst first time dislocators, young patients with trochlear dysplasia are at the highest risk for redislocation. The current standard of care for treatment of first-time dislocators without a loose body or osteochondral fracture is nonoperative management. However, recently there has been a focus on implementing a risk-stratified approach to the surgical indications for a first-time dislocator as the high-risk population might be better treated with early surgical stabilization to prevent or reduce their risk of recurrent dislocation and its associated morbidity. Likewise, for patients with recurrent dislocations, it remains to be determined whether an isolated MPFL reconstruction is sufficient for high-risk patients with several poor prognostic risk factors or if bony realignment procedures should be implemented concurrently.

髌骨不稳是一种常见的临床问题,主要影响青少年和年轻成年人。导致患者髌骨不稳的人口和解剖风险因素是多方面的,包括年龄小、女性、蹄铁发育不良、胫骨结节与蹄铁沟距离(TT-TG)增高、髌骨突出、股骨和胫骨错位、韧带松弛以及缺乏神经肌肉控制。人们一直在努力预测哪些首次脱位的患者会继续发生脱位。这一点尤为重要,因为每次脱位都会给髌股关节带来巨大的损伤风险,包括髌股关节内侧韧带(MPFL)拉伸或断裂,以及软骨损伤(从简单的裂缝到全厚软骨缺损和骨软骨骨折)。预测模型显示,在首次脱位的患者中,患有趾骨发育不良的年轻患者再次脱位的风险最高。对于没有松动体或骨软骨骨折的首次脱位患者,目前的治疗标准是采用非手术疗法。然而,最近人们开始关注对初次脱位者的手术适应症实施风险分级的方法,因为高风险人群可能更适合早期手术稳定治疗,以预防或降低其复发性脱位的风险及其相关发病率。同样,对于复发性脱位患者,对于具有多种不良预后风险因素的高危患者,孤立的MPFL重建是否足够,或者是否应同时实施骨性复位手术,仍有待确定。
{"title":"Evaluation and management of patellar instability.","authors":"Elizabeth R Dennis, Simone Gruber, William A Marmor, Beth E Shubin Stein","doi":"10.21037/aoj-2020-02","DOIUrl":"10.21037/aoj-2020-02","url":null,"abstract":"<p><p>Patellar instability is a common clinical problem that primarily affects the adolescent and young adult population. The demographic and anatomic risk factors that predispose patients to patellar instability are multifactorial and include young age, female sex, trochlear dysplasia, elevated tibial tubercle to trochlear groove distance (TT-TG), patella alta, femoral and tibial malalignment, ligamentous laxity, and lack of neuromuscular control. There have been substantial efforts to predict which patients who sustain a first-time dislocation will go on to incur additional dislocations. This is particularly important because with each dislocation event, there is a significant risk of injury to the patellofemoral joint including both medial patellofemoral ligament (MPFL) stretch or rupture and damage to the cartilage which can range from simple fissures to full-thickness cartilage defects and osteochondral fractures. Prediction models have demonstrated that amongst first time dislocators, young patients with trochlear dysplasia are at the highest risk for redislocation. The current standard of care for treatment of first-time dislocators without a loose body or osteochondral fracture is nonoperative management. However, recently there has been a focus on implementing a risk-stratified approach to the surgical indications for a first-time dislocator as the high-risk population might be better treated with early surgical stabilization to prevent or reduce their risk of recurrent dislocation and its associated morbidity. Likewise, for patients with recurrent dislocations, it remains to be determined whether an isolated MPFL reconstruction is sufficient for high-risk patients with several poor prognostic risk factors or if bony realignment procedures should be implemented concurrently.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"7 ","pages":"2"},"PeriodicalIF":0.4,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The female athlete triad. 女运动员的三要素
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2022-01-15 eCollection Date: 2022-01-01 DOI: 10.21037/aoj-2020-03
Amanda Weiss Kelly, Suzanne Hecht

The female athlete triad represents the 3 interrelated components: of energy availability (EA), menstrual function and bone health. Each component exists on a spectrum ranging from optimal health to dysfunction. Screening for the triad during the annual wellness exam, the preparticipation physical evaluation (PPE) or when the athlete presents with any single component can help identify athletes at risk. A multidisciplinary team is helpful in managing the treatment of the Triad which relies on improving EA. Screening, early recognition and aggressive treatment is important, especially in adolescent athletes to optimize bone health.

女运动员三要素代表了三个相互关联的组成部分:能量供应(EA)、月经功能和骨骼健康。每个组成部分都存在于从最佳健康到功能障碍的范围内。在年度健康检查、参赛前体能评估(PPE)或运动员出现任何单项问题时进行三联征筛查,有助于识别高危运动员。多学科团队有助于管理三联症的治疗,这有赖于改善 EA。筛查、早期识别和积极治疗对优化骨骼健康非常重要,尤其是对青少年运动员。
{"title":"The female athlete triad.","authors":"Amanda Weiss Kelly, Suzanne Hecht","doi":"10.21037/aoj-2020-03","DOIUrl":"10.21037/aoj-2020-03","url":null,"abstract":"<p><p>The female athlete triad represents the 3 interrelated components: of energy availability (EA), menstrual function and bone health. Each component exists on a spectrum ranging from optimal health to dysfunction. Screening for the triad during the annual wellness exam, the preparticipation physical evaluation (PPE) or when the athlete presents with any single component can help identify athletes at risk. A multidisciplinary team is helpful in managing the treatment of the Triad which relies on improving EA. Screening, early recognition and aggressive treatment is important, especially in adolescent athletes to optimize bone health.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"7 ","pages":"6"},"PeriodicalIF":0.4,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The multidisciplinary approach to managing prosthetic joint infection: could this lead to improved outcomes? 假体关节感染的多学科管理方法:能否改善疗效?
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2022-01-15 eCollection Date: 2022-01-01 DOI: 10.21037/aoj-2020-04
Nemandra A Sandiford, Konrad Wronka

Periprosthetic joint infection (PJI) is a devastating complication of the total joint arthroplasty (TJA). It presents a great challenge for the treating clinician. Diagnosis as well as management can prove difficult with significant morbidity for the patients and cost for patients, health care providers and society as a whole. Outcomes of equally challenging pathology such as tumors and polytrauma have been shown to be improved when patients are managed by a team as specialists as opposed to single individuals. The purpose of this study is to review the role of the multi-disciplinary team (MDT) approach in the diagnosis and management of PJI. We examine the influence of this approach on clinical outcomes in patients with PJI. We also discuss the organisational and logistical issues associated with establishment of a MDT as well as several other issues not mentioned in the contemporary orthopaedic literature. All published literature examining the role of multidisciplinary care in the management of PJI and the influence of this approach to the management and outcomes of patients with this diagnosis were included. Studies published in languages other than English were excluded. There is a paucity of data on the influence of multidisciplinary care on outcomes of the management of PJI. Evidence suggests that the MDT has important role in ensuring all factors in the management of this complex group are considered and best possible care is delivered. Multicentre randomised clinical trials are required to assess the influence of MDT'S on outcome as well as important questions around the structuring of these teams.

假体周围关节感染(PJI)是全关节成形术(TJA)的一种破坏性并发症。它给临床医生带来了巨大的挑战。诊断和治疗都很困难,患者的发病率很高,患者、医疗服务提供者和整个社会的成本也很高。事实证明,与单个个体相比,如果由一个专家团队对患者进行管理,同样具有挑战性的病理(如肿瘤和多发性创伤)的治疗效果会得到改善。本研究旨在回顾多学科团队(MDT)方法在 PJI 诊断和管理中的作用。我们研究了这种方法对 PJI 患者临床疗效的影响。我们还讨论了与建立多学科团队相关的组织和后勤问题,以及当代骨科文献中未提及的其他一些问题。我们纳入了所有已发表的文献,这些文献研究了多学科护理在PJI管理中的作用,以及这种方法对该诊断患者的管理和治疗效果的影响。除英语外,其他语言发表的研究均被排除在外。有关多学科治疗对 PJI 治疗效果的影响的数据很少。有证据表明,多学科治疗小组在确保对这一复杂群体进行管理时考虑到所有因素并提供最佳治疗方面发挥着重要作用。需要进行多中心随机临床试验,以评估 MDT 对疗效的影响,以及围绕这些团队结构的重要问题。
{"title":"The multidisciplinary approach to managing prosthetic joint infection: could this lead to improved outcomes?","authors":"Nemandra A Sandiford, Konrad Wronka","doi":"10.21037/aoj-2020-04","DOIUrl":"10.21037/aoj-2020-04","url":null,"abstract":"<p><p>Periprosthetic joint infection (PJI) is a devastating complication of the total joint arthroplasty (TJA). It presents a great challenge for the treating clinician. Diagnosis as well as management can prove difficult with significant morbidity for the patients and cost for patients, health care providers and society as a whole. Outcomes of equally challenging pathology such as tumors and polytrauma have been shown to be improved when patients are managed by a team as specialists as opposed to single individuals. The purpose of this study is to review the role of the multi-disciplinary team (MDT) approach in the diagnosis and management of PJI. We examine the influence of this approach on clinical outcomes in patients with PJI. We also discuss the organisational and logistical issues associated with establishment of a MDT as well as several other issues not mentioned in the contemporary orthopaedic literature. All published literature examining the role of multidisciplinary care in the management of PJI and the influence of this approach to the management and outcomes of patients with this diagnosis were included. Studies published in languages other than English were excluded. There is a paucity of data on the influence of multidisciplinary care on outcomes of the management of PJI. Evidence suggests that the MDT has important role in ensuring all factors in the management of this complex group are considered and best possible care is delivered. Multicentre randomised clinical trials are required to assess the influence of MDT'S on outcome as well as important questions around the structuring of these teams.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"7 ","pages":"8"},"PeriodicalIF":0.4,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In memory of Freddie Fu, AOJ’s Honorary Editor-in-Chief and renowned Pitt surgeon 为纪念《美国医学杂志》名誉总编辑、著名皮特外科医生傅福烈
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2021-10-01 DOI: 10.21037/aoj-2021-01
{"title":"In memory of Freddie Fu, AOJ’s Honorary Editor-in-Chief and renowned Pitt surgeon","authors":"","doi":"10.21037/aoj-2021-01","DOIUrl":"https://doi.org/10.21037/aoj-2021-01","url":null,"abstract":"","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46716719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biofilm formation in periprosthetic joint infections. 假体周围关节感染的生物膜形成。
IF 0.5 4区 医学 Q4 ORTHOPEDICS Pub Date : 2021-10-01 Epub Date: 2021-10-15 DOI: 10.21037/aoj-20-85
Amelia Staats, Daniel Li, Anne C Sullivan, Paul Stoodley

Formation of microbial biofilms has long been implicated in the occurrence of periprosthetic joint infections (PJIs). Despite the widespread acknowledgment of the severity of these infections, much is still unknown regarding the underlying mechanisms of biofilm establishment and proliferation in the joint space. The presence of these resilient, complex communities poses many clinical challenges with respect to prevention, diagnosis, and treatment practices. Mature biofilms are known to be highly recalcitrant to antibiotic therapeutics as well as host immune system mediated clearance. A comprehensive understanding of biofilms in the unique joint environment at the molecular level will provide clinicians valuable insight into how best to combat them. As each stage in the process of biofilm establishment has the potential for clinical intervention, this review will provide a sequential analysis of the existing literature, following each step in the formation cycle. New insights into bacterial survival mechanisms from antimicrobial challenge and host immune defenses will be discussed. These new observations in the field may shed light on the early protection conferred upon entry into the joint space ultimately leading to the establishment of a mature biofilm. Additionally, standards of clinical diagnosis as well as current measures of prevention and treatment will be briefly discussed.

长期以来,微生物生物膜的形成一直与假体周围关节感染(PJIs)的发生有关。尽管人们普遍认识到这些感染的严重性,但对于生物膜在关节间隙建立和增殖的内在机制仍有许多未知之处。这些富有弹性的复杂群落的存在给预防、诊断和治疗方法带来了许多临床挑战。众所周知,成熟的生物膜对抗生素疗法和宿主免疫系统介导的清除非常不敏感。从分子水平全面了解独特关节环境中的生物膜,将为临床医生提供宝贵的见解,帮助他们了解如何以最佳方式对抗生物膜。由于生物膜形成过程中的每个阶段都有可能进行临床干预,本综述将按照形成周期的每个步骤对现有文献进行顺序分析。将讨论从抗菌挑战和宿主免疫防御机制中了解细菌生存机制的新见解。这些新的观察结果可能会揭示细菌进入关节间隙并最终形成成熟生物膜的早期保护机制。此外,还将简要讨论临床诊断标准以及当前的预防和治疗措施。
{"title":"Biofilm formation in periprosthetic joint infections.","authors":"Amelia Staats, Daniel Li, Anne C Sullivan, Paul Stoodley","doi":"10.21037/aoj-20-85","DOIUrl":"10.21037/aoj-20-85","url":null,"abstract":"<p><p>Formation of microbial biofilms has long been implicated in the occurrence of periprosthetic joint infections (PJIs). Despite the widespread acknowledgment of the severity of these infections, much is still unknown regarding the underlying mechanisms of biofilm establishment and proliferation in the joint space. The presence of these resilient, complex communities poses many clinical challenges with respect to prevention, diagnosis, and treatment practices. Mature biofilms are known to be highly recalcitrant to antibiotic therapeutics as well as host immune system mediated clearance. A comprehensive understanding of biofilms in the unique joint environment at the molecular level will provide clinicians valuable insight into how best to combat them. As each stage in the process of biofilm establishment has the potential for clinical intervention, this review will provide a sequential analysis of the existing literature, following each step in the formation cycle. New insights into bacterial survival mechanisms from antimicrobial challenge and host immune defenses will be discussed. These new observations in the field may shed light on the early protection conferred upon entry into the joint space ultimately leading to the establishment of a mature biofilm. Additionally, standards of clinical diagnosis as well as current measures of prevention and treatment will be briefly discussed.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"6 ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f6/4f/nihms-1732890.PMC8635410.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39687762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Annals of Joint
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1