首页 > 最新文献

Annals of Joint最新文献

英文 中文
The impact of blood flow restriction therapy on orthopaedic conditions of the upper extremity: a systematic review of randomized controlled trials. 限制血流治疗对上肢骨科疾病的影响:一项随机对照试验的系统综述。
IF 0.9 4区 医学 Q4 ORTHOPEDICS Pub Date : 2026-01-23 eCollection Date: 2026-01-01 DOI: 10.21037/aoj-25-31
Samuel R Johnson, Laura Ndjonko, David Hou, Patrick England, Vehniah K Tjong, Ujash Sheth

Background: Blood flow restriction therapy (BFRT) has gained recognition in recent years as an adjunct to rehabilitation to maximize results for patients with poor strength and endurance. However, literature on the effects of BFRT for conditions afflicting the upper extremity is limited. The purpose of this study was to analyze the available literature regarding the role of BFRT in upper extremity conditions and evaluate its influence on functional and patient reported outcomes.

Methods: PubMed, Embase, and Cochrane Trials were searched in July 2024. Only randomized controlled trials (RCTs) with upper-extremity BFRT were included. Several variables were extracted, including number of patients per study, patient demographics, type of pathology, and functional outcomes. The risk of bias for each eligible RCT was evaluated using the Revised Cochrane Risk-of-Bias Tool for Randomized Trials. Standard descriptive statistics were used to report outcomes for all the included study findings. BFRT protocols were reviewed and presented in a narrative manner.

Results: The systematic literature search yielded 605 articles, of which four RCTs involving 133 patients met the inclusion criteria. The conditions evaluated included distal radius fractures, osteoarthritis of the hand, and lateral elbow tendinopathy. The evidence for all studies was deemed low risk of bias. Overall, patients who received BFRT demonstrated marginally greater strength, improved pain control, and improved patient-reported outcome measures (PROMs) when compared to a non-BFRT counterpart.

Conclusions: A comprehensive review of the literature examining BFRT as an adjunct treatment for upper extremity conditions was conducted. Patients treated with BFRT may experience greater strength, improved pain control, and improved PROMs when compared to a non-BFRT counterpart. Future, large-scale studies are necessary to further define the benefits of BFRT in orthopaedic conditions of the upper extremity.

背景:近年来,血流限制疗法(BFRT)作为一种辅助康复疗法得到了认可,可以最大限度地提高力量和耐力差患者的康复效果。然而,关于BFRT对上肢疾病影响的文献是有限的。本研究的目的是分析关于BFRT在上肢疾病中的作用的现有文献,并评估其对功能和患者报告结果的影响。方法:检索2024年7月的PubMed、Embase和Cochrane试验。仅纳入上肢BFRT的随机对照试验(rct)。提取了几个变量,包括每个研究的患者数量,患者人口统计学,病理类型和功能结果。使用Cochrane随机试验风险偏倚工具对每个符合条件的RCT进行偏倚风险评估。标准描述性统计用于报告所有纳入研究结果的结果。审查并以叙述的方式提出了核聚变试验方案。结果:系统检索到文献605篇,其中4篇rct共133例患者符合纳入标准。评估的条件包括桡骨远端骨折、手骨关节炎和肘关节外侧肌腱病变。所有研究的证据都被认为是低偏倚风险。总的来说,与未接受BFRT治疗的患者相比,接受BFRT治疗的患者表现出更强的力量、更好的疼痛控制和更好的患者报告结果测量(PROMs)。结论:我们对研究BFRT作为上肢疾病辅助治疗的文献进行了全面的回顾。与非BFRT相比,接受BFRT治疗的患者可能会经历更大的力量,更好的疼痛控制和改善的PROMs。未来,需要大规模的研究来进一步确定BFRT在上肢矫形条件下的益处。
{"title":"The impact of blood flow restriction therapy on orthopaedic conditions of the upper extremity: a systematic review of randomized controlled trials.","authors":"Samuel R Johnson, Laura Ndjonko, David Hou, Patrick England, Vehniah K Tjong, Ujash Sheth","doi":"10.21037/aoj-25-31","DOIUrl":"https://doi.org/10.21037/aoj-25-31","url":null,"abstract":"<p><strong>Background: </strong>Blood flow restriction therapy (BFRT) has gained recognition in recent years as an adjunct to rehabilitation to maximize results for patients with poor strength and endurance. However, literature on the effects of BFRT for conditions afflicting the upper extremity is limited. The purpose of this study was to analyze the available literature regarding the role of BFRT in upper extremity conditions and evaluate its influence on functional and patient reported outcomes.</p><p><strong>Methods: </strong>PubMed, Embase, and Cochrane Trials were searched in July 2024. Only randomized controlled trials (RCTs) with upper-extremity BFRT were included. Several variables were extracted, including number of patients per study, patient demographics, type of pathology, and functional outcomes. The risk of bias for each eligible RCT was evaluated using the Revised Cochrane Risk-of-Bias Tool for Randomized Trials. Standard descriptive statistics were used to report outcomes for all the included study findings. BFRT protocols were reviewed and presented in a narrative manner.</p><p><strong>Results: </strong>The systematic literature search yielded 605 articles, of which four RCTs involving 133 patients met the inclusion criteria. The conditions evaluated included distal radius fractures, osteoarthritis of the hand, and lateral elbow tendinopathy. The evidence for all studies was deemed low risk of bias. Overall, patients who received BFRT demonstrated marginally greater strength, improved pain control, and improved patient-reported outcome measures (PROMs) when compared to a non-BFRT counterpart.</p><p><strong>Conclusions: </strong>A comprehensive review of the literature examining BFRT as an adjunct treatment for upper extremity conditions was conducted. Patients treated with BFRT may experience greater strength, improved pain control, and improved PROMs when compared to a non-BFRT counterpart. Future, large-scale studies are necessary to further define the benefits of BFRT in orthopaedic conditions of the upper extremity.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"11 ","pages":"11"},"PeriodicalIF":0.9,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current standards for the objective assessment and management of posterior cruciate ligament tears: a narrative review. 后交叉韧带撕裂客观评估和治疗的现行标准:叙述性回顾。
IF 0.9 4区 医学 Q4 ORTHOPEDICS Pub Date : 2026-01-23 eCollection Date: 2026-01-01 DOI: 10.21037/aoj-25-52
Benjiman J Wilebski, Luke V Tollefson, Dustin R Lee, Matthew T Rasmussen, Robert F LaPrade

Background and objective: The posterior cruciate ligament (PCL) is the primary restraint to posterior tibial translation (PTT) and injury typically occurs during knee flexion when an external force to the tibia causes PTT. PCL injuries are often overlooked and require a comprehensive exam including a thorough history, physical examination, and imaging. This narrative review aims to review the literature on objective assessments and management of PCL tears.

Methods: A narrative review of PubMed and SCOPUS-indexed relevant literature (no date restrictions, English only, up to October 2025). Studies including reference to the PCL, PCL reconstruction, PCL imaging, and current PCL management were included.

Key content and findings: Within the literature there are multiple reported physical examination tests with varying sensitivities and specificities that aid in the diagnosis of PCL tears such as the posterior drawer, posterior sag, and quadriceps activation tests. PCL stress radiography accompanies the physical exam to provide an objective assessment of PTT while magnetic resonance imaging (MRI) is the gold standard for visualizing acute PCL tears. Nonoperative management with dynamic bracing can promote physiologic healing in grade I, isolated partial PCL tears while grade II, complete PCL tears have demonstrated improved outcomes with both non-operative and operative management. Surgical intervention is typically recommended for grade III, combined PCL injuries and the double-bundle PCL reconstruction technique has demonstrated significantly improved objective stability when compared to the single-bundle reconstruction technique.

Conclusions: Both isolated and combined PCL tears may be difficult to diagnose from other ligamentous knee injuries due to overlapping symptoms and similar physical exam findings. This may lead to misdiagnosis and the sequalae of long-term functional disabilities and future osteoarthritis. The diagnosis and determination of proper PCL tear management requires a comprehensive history, multiple physical examination tests with concomitant imaging such as PCL stress radiographs and MRI. Surgical intervention is often recommended when a grade II or higher PCL injury is demonstrated during the physical examination, or ≥8 mm of PTT (grade II) is visualized when evaluating the side-to-side differences through PCL stress radiography.

背景和目的:后交叉韧带(PCL)是胫骨后平移(PTT)的主要约束,当胫骨受到外力导致PTT时,膝关节屈曲通常会造成损伤。PCL损伤经常被忽视,需要全面的检查,包括彻底的病史、体格检查和影像学检查。这篇叙述性的综述旨在回顾关于PCL撕裂的客观评估和管理的文献。方法:对PubMed和scopus检索的相关文献进行叙述性综述(无日期限制,仅限英文,截止到2025年10月)。包括对PCL、PCL重建、PCL成像和当前PCL管理的参考研究。关键内容和发现:在文献中,有多种具有不同敏感性和特异性的体检测试,如后抽屉、后凹陷和股四头肌激活测试,有助于诊断PCL撕裂。PCL应力x线摄影伴随体检提供PTT的客观评估,而磁共振成像(MRI)是观察急性PCL撕裂的金标准。动态支具非手术治疗可促进I级孤立性部分PCL撕裂的生理性愈合,而II级完全PCL撕裂的非手术和手术治疗均可改善预后。III级合并PCL损伤通常推荐手术干预,与单束PCL重建技术相比,双束PCL重建技术已显示出显著提高客观稳定性。结论:由于症状重叠和体检结果相似,孤立性和合并性PCL撕裂可能难以与其他膝关节韧带损伤诊断。这可能导致误诊和长期功能障碍的后遗症和未来的骨关节炎。诊断和确定适当的PCL撕裂管理需要全面的病史,多次体格检查,并伴有影像学检查,如PCL应力x线片和MRI。当体格检查中发现II级或更高级别的PCL损伤,或通过PCL应力摄影评估两侧差异时发现PTT≥8mm (II级)时,通常建议进行手术干预。
{"title":"Current standards for the objective assessment and management of posterior cruciate ligament tears: a narrative review.","authors":"Benjiman J Wilebski, Luke V Tollefson, Dustin R Lee, Matthew T Rasmussen, Robert F LaPrade","doi":"10.21037/aoj-25-52","DOIUrl":"https://doi.org/10.21037/aoj-25-52","url":null,"abstract":"<p><strong>Background and objective: </strong>The posterior cruciate ligament (PCL) is the primary restraint to posterior tibial translation (PTT) and injury typically occurs during knee flexion when an external force to the tibia causes PTT. PCL injuries are often overlooked and require a comprehensive exam including a thorough history, physical examination, and imaging. This narrative review aims to review the literature on objective assessments and management of PCL tears.</p><p><strong>Methods: </strong>A narrative review of PubMed and SCOPUS-indexed relevant literature (no date restrictions, English only, up to October 2025). Studies including reference to the PCL, PCL reconstruction, PCL imaging, and current PCL management were included.</p><p><strong>Key content and findings: </strong>Within the literature there are multiple reported physical examination tests with varying sensitivities and specificities that aid in the diagnosis of PCL tears such as the posterior drawer, posterior sag, and quadriceps activation tests. PCL stress radiography accompanies the physical exam to provide an objective assessment of PTT while magnetic resonance imaging (MRI) is the gold standard for visualizing acute PCL tears. Nonoperative management with dynamic bracing can promote physiologic healing in grade I, isolated partial PCL tears while grade II, complete PCL tears have demonstrated improved outcomes with both non-operative and operative management. Surgical intervention is typically recommended for grade III, combined PCL injuries and the double-bundle PCL reconstruction technique has demonstrated significantly improved objective stability when compared to the single-bundle reconstruction technique.</p><p><strong>Conclusions: </strong>Both isolated and combined PCL tears may be difficult to diagnose from other ligamentous knee injuries due to overlapping symptoms and similar physical exam findings. This may lead to misdiagnosis and the sequalae of long-term functional disabilities and future osteoarthritis. The diagnosis and determination of proper PCL tear management requires a comprehensive history, multiple physical examination tests with concomitant imaging such as PCL stress radiographs and MRI. Surgical intervention is often recommended when a grade II or higher PCL injury is demonstrated during the physical examination, or ≥8 mm of PTT (grade II) is visualized when evaluating the side-to-side differences through PCL stress radiography.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"11 ","pages":"9"},"PeriodicalIF":0.9,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Technical considerations and early results of magnetic compressive intramedullary nailing for tibial and femoral shaft non-unions: a case series. 磁性压缩髓内钉治疗胫骨和股骨干骨不连的技术考虑和早期结果:一个病例系列。
IF 0.9 4区 医学 Q4 ORTHOPEDICS Pub Date : 2026-01-23 eCollection Date: 2026-01-01 DOI: 10.21037/aoj-25-33
Daniel J Cognetti, Jose M Gutierrez-Naranjo, Abdullah Ghali, Eduardo Valero-Moreno, Thomas L Hand, Ravi A Karia

Background: Non-union of femoral and tibial shaft fractures remains a challenging complication following surgical fixation. Magnetic intramedullary nails (mIMNs) allow controlled compression and distraction, offering a potential alternative to traditional exchange nailing or external fixation. However, limited clinical data exist regarding their efficacy and complications in treating long bone non-unions. This case series presents early outcomes and technical considerations of compressive magnetic intramedullary nailing for femoral and tibial shaft non-unions.

Case description: We conducted a retrospective case series at a level 1 trauma center in adult patients undergoing compressive magnetic intramedullary nailing of their femoral (n=5) or tibia (n=3) non-unions between 2017 and 2022. Eight patients were included with a mean age at surgery of 38±16 years and a mean follow-up of 16.1±8.7 months. All patients had at least one prior surgical procedure before mIMN. Five patients (62.5%) sustained initial open fractures. Six of eight patients (75%) achieved radiographic union at a mean of 6±2.6 months. Two patients did not achieve union for distinct reasons: one patient required an above-knee amputation due to deep infection, while the other, who had a persistent distal docking site non-union following bone transport with a magnetic nail, refused the recommended secondary surgery for bone grafting at the site.

Conclusions: mIMNs are a potential solution for complex tibial and femoral shaft non-unions, providing stable fixation while enabling controlled bone transport without the need for external fixation. Early results demonstrate satisfactory union rates. However, comparative studies are required to clarify optimal indications, timing of compression, and long-term outcomes.

背景:股骨和胫干骨折不愈合仍然是手术固定后的一个具有挑战性的并发症。磁性髓内钉(mIMNs)允许控制压缩和牵引,提供了传统交换钉或外固定的潜在替代方案。然而,关于其治疗长骨不连的疗效和并发症的临床资料有限。本病例系列介绍了压缩磁性髓内钉治疗股骨和胫骨骨不连的早期结果和技术考虑。病例描述:我们在一级创伤中心对2017年至2022年间接受股骨(n=5)或胫骨(n=3)骨不连压缩磁性髓内钉治疗的成人患者进行了回顾性病例系列。8例患者平均手术年龄38±16岁,平均随访16.1±8.7个月。所有患者在行mIMN前至少有过一次外科手术。5例患者(62.5%)持续首发开放性骨折。8例患者中有6例(75%)在平均6±2.6个月的时间内实现了影像学愈合。两例患者由于不同的原因未能愈合:一名患者因深部感染需要进行膝上截肢,而另一名患者在磁钉骨转运后远端对接部位持续不愈合,拒绝在该部位进行二次手术植骨。结论:mimn是复杂胫骨和股骨干骨不连的潜在解决方案,提供稳定的固定,同时无需外固定物即可控制骨运输。早期结果显示令人满意的愈合率。然而,需要比较研究来阐明最佳适应症、加压时间和长期结果。
{"title":"Technical considerations and early results of magnetic compressive intramedullary nailing for tibial and femoral shaft non-unions: a case series.","authors":"Daniel J Cognetti, Jose M Gutierrez-Naranjo, Abdullah Ghali, Eduardo Valero-Moreno, Thomas L Hand, Ravi A Karia","doi":"10.21037/aoj-25-33","DOIUrl":"https://doi.org/10.21037/aoj-25-33","url":null,"abstract":"<p><strong>Background: </strong>Non-union of femoral and tibial shaft fractures remains a challenging complication following surgical fixation. Magnetic intramedullary nails (mIMNs) allow controlled compression and distraction, offering a potential alternative to traditional exchange nailing or external fixation. However, limited clinical data exist regarding their efficacy and complications in treating long bone non-unions. This case series presents early outcomes and technical considerations of compressive magnetic intramedullary nailing for femoral and tibial shaft non-unions.</p><p><strong>Case description: </strong>We conducted a retrospective case series at a level 1 trauma center in adult patients undergoing compressive magnetic intramedullary nailing of their femoral (n=5) or tibia (n=3) non-unions between 2017 and 2022. Eight patients were included with a mean age at surgery of 38±16 years and a mean follow-up of 16.1±8.7 months. All patients had at least one prior surgical procedure before mIMN. Five patients (62.5%) sustained initial open fractures. Six of eight patients (75%) achieved radiographic union at a mean of 6±2.6 months. Two patients did not achieve union for distinct reasons: one patient required an above-knee amputation due to deep infection, while the other, who had a persistent distal docking site non-union following bone transport with a magnetic nail, refused the recommended secondary surgery for bone grafting at the site.</p><p><strong>Conclusions: </strong>mIMNs are a potential solution for complex tibial and femoral shaft non-unions, providing stable fixation while enabling controlled bone transport without the need for external fixation. Early results demonstrate satisfactory union rates. However, comparative studies are required to clarify optimal indications, timing of compression, and long-term outcomes.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"11 ","pages":"8"},"PeriodicalIF":0.9,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary is not a substitute for evidence generation. 评论不能代替证据的产生。
IF 0.9 4区 医学 Q4 ORTHOPEDICS Pub Date : 2026-01-23 eCollection Date: 2026-01-01 DOI: 10.21037/aoj-2025-1-91
Filippo Migliorini, Nicola Maffulli
{"title":"Commentary is not a substitute for evidence generation.","authors":"Filippo Migliorini, Nicola Maffulli","doi":"10.21037/aoj-2025-1-91","DOIUrl":"https://doi.org/10.21037/aoj-2025-1-91","url":null,"abstract":"","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"11 ","pages":"15"},"PeriodicalIF":0.9,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision anterior cruciate ligament (ACL) reconstruction in high-level athletes. 高水平运动员前交叉韧带(ACL)精确重建。
IF 0.9 4区 医学 Q4 ORTHOPEDICS Pub Date : 2026-01-22 eCollection Date: 2026-01-01 DOI: 10.21037/aoj-25-58
Romed P Vieider, Jacob Hartline, Justin Lau, Karina Dias, Anja M Wackerle, Volker Musahl

Anterior cruciate ligament (ACL) tear is a common injury in high-level athletes and has a significant impact on a professional career. Precision management is necessary for successful return to sports (RTS) and return to a competitive level, referred to as return to play (RTP). ACL reconstruction (ACLR) is considered the gold standard and restores anteroposterior and rotatory knee stability to facilitate a successful comeback in the elite athlete's sport. Despite an overall high RTS and RTP rate in elite athletes, performance and career longevity can be significantly impacted. Management of ACL injury in an elite athlete should be individualized to address the demands of the sport and the athlete's expectations. Optimal treatment includes the proper graft choice, detailed sport-specific rehabilitation, and metrics for psychological readiness to RTS and RTP. Hamstring tendon (HT), quadriceps tendon (QT), and bone-patellar tendon-bone (BPTB) autograft for ACLR are the most widely used grafts in athletes. Each graft has a specific profile of characteristics, with BPTB and QT autografts showing the lowest failure rates compared to HT autografts. Graft-specific complications represent anterior knee pain in BPTB, functional weakness of the extensor mechanism of the knee when using QT autografts, and a higher failure rate in HT autografts. Concomitant injuries are common, with meniscus, chondral, and medial collateral ligament lesions being most frequent. Meniscus injuries should be repaired, and early timing plays a crucial role, considering good outcomes after meniscus repair in combined ACLR. Rehabilitation in high-level athletes is recommended to be based on functional criteria rather than purely on a timeline. Successful rehabilitation with the goal of RTP should include prevention of re-injury, progressive muscle strengthening, neuromuscular training, and sport-specific functional exercises.

前交叉韧带(ACL)撕裂是高水平运动员常见的损伤,对职业生涯有重大影响。精确的管理是成功回归运动(RTS)和回归竞争水平(即回归游戏(RTP))的必要条件。前交叉韧带重建(ACLR)被认为是黄金标准,可以恢复膝关节前后和旋转的稳定性,以促进精英运动员运动的成功回归。尽管精英运动员的RTS和RTP率总体较高,但表现和职业生涯寿命会受到显著影响。精英运动员前交叉韧带损伤的处理应个性化,以满足运动的要求和运动员的期望。最佳治疗包括适当的移植物选择,详细的运动特异性康复,以及RTS和RTP的心理准备指标。腘绳肌腱(HT)、股四头肌肌腱(QT)和骨-髌骨肌腱-骨(BPTB)自体移植物是运动员ACLR最广泛使用的移植物。每种移植物都具有特定的特征,与HT自体移植物相比,BPTB和QT自体移植物的失败率最低。移植物特异性并发症包括BPTB患者的膝关节前侧疼痛,QT自体移植物患者的膝关节伸肌机制功能无力,以及HT自体移植物患者的失败率较高。伴随性损伤是常见的,以半月板、软骨和内侧副韧带病变最为常见。考虑到联合ACLR半月板修复后的良好预后,半月板损伤应进行修复,早期时机起着至关重要的作用。高水平运动员的康复建议基于功能标准,而不是单纯的时间表。以RTP为目标的成功康复应包括预防再损伤、渐进式肌肉强化、神经肌肉训练和运动特异性功能锻炼。
{"title":"Precision anterior cruciate ligament (ACL) reconstruction in high-level athletes.","authors":"Romed P Vieider, Jacob Hartline, Justin Lau, Karina Dias, Anja M Wackerle, Volker Musahl","doi":"10.21037/aoj-25-58","DOIUrl":"https://doi.org/10.21037/aoj-25-58","url":null,"abstract":"<p><p>Anterior cruciate ligament (ACL) tear is a common injury in high-level athletes and has a significant impact on a professional career. Precision management is necessary for successful return to sports (RTS) and return to a competitive level, referred to as return to play (RTP). ACL reconstruction (ACLR) is considered the gold standard and restores anteroposterior and rotatory knee stability to facilitate a successful comeback in the elite athlete's sport. Despite an overall high RTS and RTP rate in elite athletes, performance and career longevity can be significantly impacted. Management of ACL injury in an elite athlete should be individualized to address the demands of the sport and the athlete's expectations. Optimal treatment includes the proper graft choice, detailed sport-specific rehabilitation, and metrics for psychological readiness to RTS and RTP. Hamstring tendon (HT), quadriceps tendon (QT), and bone-patellar tendon-bone (BPTB) autograft for ACLR are the most widely used grafts in athletes. Each graft has a specific profile of characteristics, with BPTB and QT autografts showing the lowest failure rates compared to HT autografts. Graft-specific complications represent anterior knee pain in BPTB, functional weakness of the extensor mechanism of the knee when using QT autografts, and a higher failure rate in HT autografts. Concomitant injuries are common, with meniscus, chondral, and medial collateral ligament lesions being most frequent. Meniscus injuries should be repaired, and early timing plays a crucial role, considering good outcomes after meniscus repair in combined ACLR. Rehabilitation in high-level athletes is recommended to be based on functional criteria rather than purely on a timeline. Successful rehabilitation with the goal of RTP should include prevention of re-injury, progressive muscle strengthening, neuromuscular training, and sport-specific functional exercises.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"11 ","pages":"10"},"PeriodicalIF":0.9,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence models cannot yet replace experts in providing patient education for shoulder and elbow orthopaedic pathologies: a systematic review and meta-analysis. 人工智能模型还不能取代专家为患者提供肩关节矫形病理教育:一项系统回顾和荟萃分析。
IF 0.9 4区 医学 Q4 ORTHOPEDICS Pub Date : 2026-01-22 eCollection Date: 2026-01-01 DOI: 10.21037/aoj-25-38
Joshua Dworsky-Fried, Matthew Mellon, Preksha Rathod, James Yan, Moin Khan

Background: AI and machine learning (ML) have diverse applications in orthopedic surgery, such as for diagnosis of disease, surgical assistance, and outcome prediction. When used as adjuncts, AI has a potential to reduce clinical workload, improve workflow and aid in clinical decision making. The objective of this systematic review is to evaluate current literature on artificial intelligence (AI) to assess effectiveness in developing responses to inquiries related to orthopaedic upper extremity pathologies.

Methods: Three databases (PubMed, MEDLINE, EMBASE) were searched for studies involving AI and questions in shoulder and elbow orthopedics. Inclusion criteria included papers related to shoulder and elbow, human studies, use of AI models, published in English language and at any level of evidence. Data on response accuracy, reliability and quality, as well as area under the curve (AUC) of the given AI algorithm, were recorded. Meta-analyses were conducted on both the accuracy and AUC of AI algorithms on relevant studies. Risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2).

Results: A total of 16 studies were included in this review. Nine studies used a version of ChatGPT, one study used GoogleBard, and the remaining seven studies used a variety of AI learning models. The overall pooled accuracy of responses developed by AI models was 78%, and the pooled mean AUC of included AI algorithms was 86%. AI algorithms performed inferiorly compared to experts. The overall quality and readability of AI responses were poor.

Conclusions: AI algorithms assessed in our study demonstrated a promising degree of accuracy and performance. However, AI responses were found to be inferior to experts and had poor readability, quality, and value to the patient. In its current state of technology, AI is a powerful tool that can be used in conjunction with experts to augment patient education, however, it should not be utilized independently.

背景:人工智能和机器学习(ML)在骨科手术中有多种应用,如疾病诊断、手术辅助和结果预测。当用作辅助工具时,人工智能有可能减少临床工作量,改善工作流程并帮助临床决策。本系统综述的目的是评估当前关于人工智能(AI)的文献,以评估其在骨科上肢病理相关询问的响应方面的有效性。方法:检索PubMed、MEDLINE、EMBASE三个数据库,检索人工智能在肩关节矫形术中的相关研究和问题。纳入标准包括与肩部和肘部、人体研究、人工智能模型的使用有关的论文,以及以英语和任何证据水平发表的论文。记录给定AI算法的响应精度、可靠性和质量以及曲线下面积(AUC)数据。对相关研究中人工智能算法的准确率和AUC进行meta分析。使用诊断准确性研究质量评估(QUADAS-2)评估偏倚风险。结果:本综述共纳入16项研究。九项研究使用了ChatGPT的一个版本,一项研究使用了GoogleBard,其余七项研究使用了各种人工智能学习模型。人工智能模型开发的响应的总体汇总准确率为78%,所包含的人工智能算法的汇总平均AUC为86%。人工智能算法的表现不如专家。人工智能回答的整体质量和可读性较差。结论:在我们的研究中评估的人工智能算法显示出有希望的准确性和性能。然而,人们发现人工智能的回答不如专家,可读性、质量和对患者的价值都很差。就目前的技术水平而言,人工智能是一个强大的工具,可以与专家一起使用,以加强患者教育,但不应该单独使用。
{"title":"Artificial intelligence models cannot yet replace experts in providing patient education for shoulder and elbow orthopaedic pathologies: a systematic review and meta-analysis.","authors":"Joshua Dworsky-Fried, Matthew Mellon, Preksha Rathod, James Yan, Moin Khan","doi":"10.21037/aoj-25-38","DOIUrl":"https://doi.org/10.21037/aoj-25-38","url":null,"abstract":"<p><strong>Background: </strong>AI and machine learning (ML) have diverse applications in orthopedic surgery, such as for diagnosis of disease, surgical assistance, and outcome prediction. When used as adjuncts, AI has a potential to reduce clinical workload, improve workflow and aid in clinical decision making. The objective of this systematic review is to evaluate current literature on artificial intelligence (AI) to assess effectiveness in developing responses to inquiries related to orthopaedic upper extremity pathologies.</p><p><strong>Methods: </strong>Three databases (PubMed, MEDLINE, EMBASE) were searched for studies involving AI and questions in shoulder and elbow orthopedics. Inclusion criteria included papers related to shoulder and elbow, human studies, use of AI models, published in English language and at any level of evidence. Data on response accuracy, reliability and quality, as well as area under the curve (AUC) of the given AI algorithm, were recorded. Meta-analyses were conducted on both the accuracy and AUC of AI algorithms on relevant studies. Risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2).</p><p><strong>Results: </strong>A total of 16 studies were included in this review. Nine studies used a version of ChatGPT, one study used GoogleBard, and the remaining seven studies used a variety of AI learning models. The overall pooled accuracy of responses developed by AI models was 78%, and the pooled mean AUC of included AI algorithms was 86%. AI algorithms performed inferiorly compared to experts. The overall quality and readability of AI responses were poor.</p><p><strong>Conclusions: </strong>AI algorithms assessed in our study demonstrated a promising degree of accuracy and performance. However, AI responses were found to be inferior to experts and had poor readability, quality, and value to the patient. In its current state of technology, AI is a powerful tool that can be used in conjunction with experts to augment patient education, however, it should not be utilized independently.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"11 ","pages":"6"},"PeriodicalIF":0.9,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Academic, leadership, and demographic characteristics of orthopaedic arthroplasty leadership: a 2022 cross-sectional study. 骨科关节成形术领导的学术、领导和人口统计学特征:2022年横断面研究。
IF 0.9 4区 医学 Q4 ORTHOPEDICS Pub Date : 2026-01-22 eCollection Date: 2026-01-01 DOI: 10.21037/aoj-24-59
Maksym Bartashevskyy, Jonathan Clausen, Ross Clarke, Emily Curry, Peter Boufadel, Daniel Pare, Noorullah Maqsoodi, Xinning Li

Background: Orthopaedic Fellowship Directors (FDs) and Division Chiefs (DCs) have a profound impact on trainee development. The purpose of this study was to identify and evaluate common demographic and academic characteristics among both FDs and DCs within orthopaedic arthroplasty divisions in the United States.

Methods: Adult reconstruction fellowship and residency programs were identified through the AAHKS Fellowship Match Program list and AMA's FREIDA database. Data on FDs and DCs were collected from program websites and verified through AAHKS listings. Demographic, academic, and professional information, including sex, race/ethnicity, education, fellowship training, academic rank, leadership roles, institutional tenure, and patient satisfaction, were obtained from publicly available sources such as online curricula vitae, Doximity, and LinkedIn. Research productivity metrics, including h-index, total publications, and ResearchGate (RG) scores, were extracted from Scopus and RG databases.

Results: One hundred and sixteen FDs and 77 DCs from 137 orthopaedic arthroplasty programs were included. 98.2% of surgeons were males. Racial demographics were comprised of 83.4% Caucasian, 11.2% Asian, 3.6% Hispanic, and 1.8% African Americans. The mean age was 52.7 years, with an average of 18.1 years since fellowship completion, 13.8 years at the current institution, and 9.7 years in respective leadership role. Thirty leaders (17.8%) held additional graduate degrees, and 68 (40.2%) occupied other leadership positions within their departments or hospitals. The average h-index was 16.9. In terms of academic rank, 29.9% of surgeons were Full Professors, while 26.6% and 23.1% were Associate and Assistant professors, respectively. There was a moderate positive correlation between academic rank and h-index (r=0.46). Fellowship programs that graduated the most FDs and DCs were Massachusetts General Hospital [17], Hospital for Special Surgery [17] and Mayo Clinic [13].

Conclusions: The majority of orthopaedic arthroplasty FDs and DCs are male and Caucasian, many hold additional leadership roles, and a small number of fellowship programs produce a disproportionately high number of current leaders. These findings highlight the need for targeted efforts to increase gender diversity and mentorship to strengthen the future of academic arthroplasty and improve training and patient care.

背景:骨科奖学金主任(FDs)和部门主任(dc)对实习生的发展有着深远的影响。本研究的目的是确定和评估美国骨科关节成形术部门fd和dc的共同人口统计学和学术特征。方法:通过AAHKS奖学金匹配项目列表和AMA的FREIDA数据库确定成人重建奖学金和住院医师项目。fd和dc的数据从项目网站上收集,并通过AAHKS列表进行验证。人口统计、学术和专业信息,包括性别、种族/民族、教育、奖学金培训、学术等级、领导角色、机构任期和患者满意度,从在线简历、Doximity和LinkedIn等公开来源获得。从Scopus和RG数据库中提取研究生产力指标,包括h指数、总出版物和ResearchGate (RG)分数。结果:纳入137个骨科关节成形术项目的116例fd和77例dc。98.2%的外科医生为男性。种族人口统计包括83.4%的高加索人,11.2%的亚洲人,3.6%的西班牙裔和1.8%的非洲裔美国人。平均年龄为52.7岁,完成奖学金的平均年龄为18.1年,目前所在机构的平均年龄为13.8年,各自担任领导职务的平均年龄为9.7年。30名领导(17.8%)拥有额外的研究生学位,68名(40.2%)在其部门或医院担任其他领导职务。平均h指数为16.9。在学术排名方面,29.9%的外科医生为正教授,26.6%为副教授,23.1%为副教授。学术等级与h指数有中度正相关(r=0.46)。毕业于FDs和dc最多的奖学金项目是马萨诸塞州总医院bbb、特殊外科医院[17]和梅奥诊所[13]。结论:大多数骨科关节置换术fd和dc是男性和高加索人,许多人担任额外的领导角色,少数奖学金项目产生了不成比例的高数量的现任领导者。这些发现强调需要有针对性地努力增加性别多样性和指导,以加强学术关节置换术的未来,改善培训和患者护理。
{"title":"Academic, leadership, and demographic characteristics of orthopaedic arthroplasty leadership: a 2022 cross-sectional study.","authors":"Maksym Bartashevskyy, Jonathan Clausen, Ross Clarke, Emily Curry, Peter Boufadel, Daniel Pare, Noorullah Maqsoodi, Xinning Li","doi":"10.21037/aoj-24-59","DOIUrl":"https://doi.org/10.21037/aoj-24-59","url":null,"abstract":"<p><strong>Background: </strong>Orthopaedic Fellowship Directors (FDs) and Division Chiefs (DCs) have a profound impact on trainee development. The purpose of this study was to identify and evaluate common demographic and academic characteristics among both FDs and DCs within orthopaedic arthroplasty divisions in the United States.</p><p><strong>Methods: </strong>Adult reconstruction fellowship and residency programs were identified through the AAHKS Fellowship Match Program list and AMA's FREIDA database. Data on FDs and DCs were collected from program websites and verified through AAHKS listings. Demographic, academic, and professional information, including sex, race/ethnicity, education, fellowship training, academic rank, leadership roles, institutional tenure, and patient satisfaction, were obtained from publicly available sources such as online curricula vitae, Doximity, and LinkedIn. Research productivity metrics, including h-index, total publications, and ResearchGate (RG) scores, were extracted from Scopus and RG databases.</p><p><strong>Results: </strong>One hundred and sixteen FDs and 77 DCs from 137 orthopaedic arthroplasty programs were included. 98.2% of surgeons were males. Racial demographics were comprised of 83.4% Caucasian, 11.2% Asian, 3.6% Hispanic, and 1.8% African Americans. The mean age was 52.7 years, with an average of 18.1 years since fellowship completion, 13.8 years at the current institution, and 9.7 years in respective leadership role. Thirty leaders (17.8%) held additional graduate degrees, and 68 (40.2%) occupied other leadership positions within their departments or hospitals. The average h-index was 16.9. In terms of academic rank, 29.9% of surgeons were Full Professors, while 26.6% and 23.1% were Associate and Assistant professors, respectively. There was a moderate positive correlation between academic rank and h-index (r=0.46). Fellowship programs that graduated the most FDs and DCs were Massachusetts General Hospital [17], Hospital for Special Surgery [17] and Mayo Clinic [13].</p><p><strong>Conclusions: </strong>The majority of orthopaedic arthroplasty FDs and DCs are male and Caucasian, many hold additional leadership roles, and a small number of fellowship programs produce a disproportionately high number of current leaders. These findings highlight the need for targeted efforts to increase gender diversity and mentorship to strengthen the future of academic arthroplasty and improve training and patient care.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"11 ","pages":"3"},"PeriodicalIF":0.9,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Excision of proximal fibular aggressive and malignant tumors: a new classification for surgical guidance. 腓骨近端侵袭性恶性肿瘤的切除:手术指导的新分类。
IF 0.9 4区 医学 Q4 ORTHOPEDICS Pub Date : 2026-01-22 eCollection Date: 2026-01-01 DOI: 10.21037/aoj-25-47
Yuan Gao, Jing Wang, Jun Zhang, Feng Pan, Guanning Shang

Background: Patients with aggressive and malignant tumors of the proximal fibula may require en bloc resection to reduce the recurrence rate. We aimed to analyze the clinical curative effect of the surgical treatment of proximal fibula tumors, and the relationship between a new classification system and functional evaluation of the knee and ankle joint.

Methods: Between July 2010 and February 2022, 30 patients with proximal fibula tumors were treated, of which 27 had primary tumors and three had recurrent tumors. The histologic diagnoses were aggressive osteoblastoma (three patients), 'active' osteochondroma (five patients), giant cell tumor of the bone (11 patients), chondrosarcoma (four patients), osteosarcoma (six patients), and metastatic carcinoma (one patient). The surgical methods were divided into four types according to two important anatomical structures-the deep peroneal nerve (DPN) and proximal tibiofibular joint (PTFJ). Brief descriptions of the removal methods are as follows. Type I includes intra-articular resection of the PTFJ and preservation of the DPN. Type II includes the resection of the DPN and intra-articular resection of the PTFJ. Type III includes extra-articular PTFJ resection and preservation of the DPN. Type IV includes extra-articular PTFJ resection and resection of the DPN.

Results: The 30 patients with proximal fibula tumor underwent successful operation. Those who underwent type I and type III procedures had normal ankle function because the DPN was preserved; however, in those who underwent type II and type IV procedures with resection of the DPN, ankle foot orthosis was needed to stabilize the ankle joint because of the resulting drop foot. In those who underwent type I and type II procedures with intra-articular PTFJ resection, the preservation of the lateral collateral ligament, biceps tendon, and popliteal tendon partly protected the structure of the knee joint, leading to postoperative knee joint stability. In those who underwent type III and type IV procedures with extra-articular PTFJ resection, gait abnormalities and knee instability occurred.

Conclusions: The peroneal nerve and PTFJ are adjacent to each other, and resection of proximal fibular tumors is challenging for orthopedic surgeons. The DPN and PTFJ classification can lead to better surgical planning and postoperative functional evaluation. It provides useful information for the standardized treatment of proximal peroneal tumors based on regional anatomy.

背景:腓骨近端侵袭性恶性肿瘤患者可能需要整体切除以降低复发率。我们旨在分析腓骨近端肿瘤手术治疗的临床疗效,以及新的分类系统与膝关节和踝关节功能评价的关系。方法:2010年7月至2022年2月对30例腓骨近端肿瘤患者进行治疗,其中原发肿瘤27例,复发肿瘤3例。组织学诊断为侵袭性成骨细胞瘤(3例)、活动性骨软骨瘤(5例)、骨巨细胞瘤(11例)、软骨肉瘤(4例)、骨肉瘤(6例)和转移性癌(1例)。根据腓深神经(DPN)和胫腓近端关节(PTFJ)这两个重要解剖结构,将手术方法分为四种。下面简要介绍几种清除方法。I型包括关节内切除PTFJ和保留DPN。II型包括DPN切除术和PTFJ关节内切除术。III型包括关节外PTFJ切除和DPN保留。IV型包括关节外PTFJ切除术和DPN切除术。结果:30例腓骨近端肿瘤手术成功。接受I型和III型手术的患者踝关节功能正常,因为DPN得到了保留;然而,在那些接受II型和IV型手术切除DPN的患者中,由于产生下垂足,需要使用踝足矫形器来稳定踝关节。在那些接受I型和II型手术并关节内PTFJ切除术的患者中,外侧副韧带、二头肌肌腱和腘肌腱的保留部分保护了膝关节的结构,导致术后膝关节稳定。在接受III型和IV型手术并关节外PTFJ切除术的患者中,发生步态异常和膝关节不稳定。结论:腓神经与腓骨近端肿瘤相邻,切除腓骨近端肿瘤对骨科医生来说是一个挑战。DPN和PTFJ的分类有助于更好的手术计划和术后功能评估。为腓近端肿瘤的规范化治疗提供了基于区域解剖的有用信息。
{"title":"Excision of proximal fibular aggressive and malignant tumors: a new classification for surgical guidance.","authors":"Yuan Gao, Jing Wang, Jun Zhang, Feng Pan, Guanning Shang","doi":"10.21037/aoj-25-47","DOIUrl":"https://doi.org/10.21037/aoj-25-47","url":null,"abstract":"<p><strong>Background: </strong>Patients with aggressive and malignant tumors of the proximal fibula may require <i>en bloc</i> resection to reduce the recurrence rate. We aimed to analyze the clinical curative effect of the surgical treatment of proximal fibula tumors, and the relationship between a new classification system and functional evaluation of the knee and ankle joint.</p><p><strong>Methods: </strong>Between July 2010 and February 2022, 30 patients with proximal fibula tumors were treated, of which 27 had primary tumors and three had recurrent tumors. The histologic diagnoses were aggressive osteoblastoma (three patients), 'active' osteochondroma (five patients), giant cell tumor of the bone (11 patients), chondrosarcoma (four patients), osteosarcoma (six patients), and metastatic carcinoma (one patient). The surgical methods were divided into four types according to two important anatomical structures-the deep peroneal nerve (DPN) and proximal tibiofibular joint (PTFJ). Brief descriptions of the removal methods are as follows. Type I includes intra-articular resection of the PTFJ and preservation of the DPN. Type II includes the resection of the DPN and intra-articular resection of the PTFJ. Type III includes extra-articular PTFJ resection and preservation of the DPN. Type IV includes extra-articular PTFJ resection and resection of the DPN.</p><p><strong>Results: </strong>The 30 patients with proximal fibula tumor underwent successful operation. Those who underwent type I and type III procedures had normal ankle function because the DPN was preserved; however, in those who underwent type II and type IV procedures with resection of the DPN, ankle foot orthosis was needed to stabilize the ankle joint because of the resulting drop foot. In those who underwent type I and type II procedures with intra-articular PTFJ resection, the preservation of the lateral collateral ligament, biceps tendon, and popliteal tendon partly protected the structure of the knee joint, leading to postoperative knee joint stability. In those who underwent type III and type IV procedures with extra-articular PTFJ resection, gait abnormalities and knee instability occurred.</p><p><strong>Conclusions: </strong>The peroneal nerve and PTFJ are adjacent to each other, and resection of proximal fibular tumors is challenging for orthopedic surgeons. The DPN and PTFJ classification can lead to better surgical planning and postoperative functional evaluation. It provides useful information for the standardized treatment of proximal peroneal tumors based on regional anatomy.</p>","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"11 ","pages":"7"},"PeriodicalIF":0.9,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The epidemiology of revision total hip arthroplasty: rising demand, younger patients, and the maintaining value. 翻修全髋关节置换术的流行病学:需求上升、患者年轻化和维持价值。
IF 0.9 4区 医学 Q4 ORTHOPEDICS Pub Date : 2026-01-22 eCollection Date: 2026-01-01 DOI: 10.21037/aoj-25-69
Nemandra Amir Sandiford, Mustafa Citak
{"title":"The epidemiology of revision total hip arthroplasty: rising demand, younger patients, and the maintaining value.","authors":"Nemandra Amir Sandiford, Mustafa Citak","doi":"10.21037/aoj-25-69","DOIUrl":"https://doi.org/10.21037/aoj-25-69","url":null,"abstract":"","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"11 ","pages":"1"},"PeriodicalIF":0.9,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracorporeal shock wave therapy alleviates glucocorticoid-induced injury and dysfunction of bone microvascular endothelial cells via the PI3K/AKT/FOXO1 pathway. 体外冲击波治疗通过PI3K/AKT/FOXO1通路缓解糖皮质激素诱导的骨微血管内皮细胞损伤和功能障碍。
IF 0.9 4区 医学 Q4 ORTHOPEDICS Pub Date : 2026-01-21 eCollection Date: 2026-01-01 DOI: 10.21037/aoj-25-36
Yu Zhou, Dehui Song, Haoyang Liu, Hongxu Li, Bailiang Wang, Wei Sun
<p><strong>Background: </strong>Glucocorticoid-induced osteonecrosis of the femoral head (ONFH) is a common orthopedic condition with a high disability rate, and its pathogenesis remains incompletely understood. Increasing evidence suggests that glucocorticoid-induced damage and dysfunction of bone microvascular endothelial cells (BMECs) play a crucial role in the development and progression of ONFH. Glucocorticoids can cause damage and apoptosis of vascular endothelial cells, triggering coagulopathy and sustained inflammation. These pathological alterations contribute to thrombosis and microcirculatory disturbances, eventually leading to ischemic ONFH. As a non-invasive treatment modality, extracorporeal shock wave therapy (ESWT) offers several advantages, including its non-invasive nature, adjustable stimulation intensity, low procedural risk, and minimal complications. ESWT has been shown to relieve pain, improve hip joint function, and delay disease progression in ONFH patients. Moreover, several studies have reported that the therapeutic efficacy of ESWT is superior to that of core decompression or core decompression combined with bone grafting. However, the underlying mechanisms of its effectiveness remain unclear. This study aimed to investigate the effects and potential mechanisms of ESWT in an <i>in vitro</i> model of glucocorticoid-induced BMECs injury.</p><p><strong>Methods: </strong>An <i>in vitro</i> model of glucocorticoid-induced injury in BMECs was established, and various intensities of ESWT were applied to determine the optimal treatment parameters. To assess the therapeutic effects of ESWT on glucocorticoid-induced injury in BMECs, cell viability, proliferation, angiogenic capacity, migration, and apoptosis were evaluated using the Cell Counting Kit-8 (CCK-8) assay, 5-ethynyl-2'-deoxyuridine (EdU) incorporation assay, tube formation assay, wound healing and Transwell assays, and Annexin V-fluorescein isothiocyanate (FITC)/propidium iodide (PI) assay, respectively. In addition, Western blot analysis was conducted to examine the expression levels of PI3K, phospho- (p-)PI3K, AKT, p-AKT, FOXO1, and p-FOXO1. The involvement of the PI3K/AKT/FOXO1 signaling pathway in the protective effect of ESWT was further validated using a specific PI3K inhibitor LY294002.</p><p><strong>Results: </strong>Our study demonstrated that the biological effects of ESWT exhibit a dose-dependent pattern, and 0.06 mJ/mm<sup>2</sup> with 1,000 pulses may represent the optimal parameter for alleviating glucocorticoid-induced injury in BMECs. ESWT effectively mitigated BMEC injury and dysfunction caused by glucocorticoid exposure, as evidenced by enhanced cell viability, proliferation, angiogenic capacity, and migration ability, as well as reduced apoptosis. Western blot analysis further revealed that ESWT treatment significantly increased the phosphorylation levels of PI3K, AKT, and FOXO1, as indicated by elevated p-PI3K/PI3K, p-AKT/AKT, and p-FOXO1/FOXO1 rat
背景:糖皮质激素性股骨头坏死(ONFH)是一种常见的骨科疾病,致残率高,其发病机制尚不完全清楚。越来越多的证据表明,糖皮质激素诱导的骨微血管内皮细胞(BMECs)损伤和功能障碍在ONFH的发生和发展中起着至关重要的作用。糖皮质激素可引起血管内皮细胞损伤和凋亡,引发凝血功能障碍和持续炎症。这些病理改变导致血栓形成和微循环紊乱,最终导致缺血性ONFH。作为一种非侵入性治疗方式,体外冲击波治疗(ESWT)具有非侵入性、刺激强度可调、手术风险低、并发症少等优点。ESWT已被证明可以缓解ONFH患者的疼痛,改善髋关节功能,并延缓疾病进展。此外,有研究报道ESWT的治疗效果优于髓核减压或髓核减压联合植骨。然而,其有效性的潜在机制仍不清楚。本研究旨在探讨ESWT在糖皮质激素诱导bmec损伤的体外模型中的作用及其可能的机制。方法:建立bmec体外糖皮质激素损伤模型,采用不同强度的ESWT,确定最佳治疗参数。为了评估ESWT对糖皮质激素诱导的BMECs损伤的治疗效果,分别采用细胞计数试剂盒-8 (CCK-8)法、5-乙基-2'-脱氧尿苷(EdU)结合法、管形成法、伤口愈合和Transwell法以及膜联蛋白v -异硫氰酸荧光素(FITC)/碘化丙啶(PI)法评估ESWT对BMECs细胞活力、增殖、血管生成能力、迁移和凋亡的影响。Western blot检测PI3K、phospho- (p-)PI3K、AKT、p-AKT、FOXO1、p-FOXO1的表达水平。使用特异性PI3K抑制剂LY294002进一步验证了PI3K/AKT/FOXO1信号通路参与ESWT的保护作用。结果:我们的研究表明,ESWT的生物学效应呈现剂量依赖模式,0.06 mJ/mm2, 1000次脉冲可能是减轻bmec糖皮质激素诱导损伤的最佳参数。ESWT有效减轻糖皮质激素暴露引起的BMEC损伤和功能障碍,增强细胞活力、增殖、血管生成能力和迁移能力,减少细胞凋亡。Western blot分析进一步显示,ESWT处理显著提高了PI3K、AKT和FOXO1的磷酸化水平,p-PI3K/PI3K、p-AKT/AKT和p-FOXO1/FOXO1比值升高。此外,ESWT的这些保护作用被PI3K抑制剂LY294002所消除。结论:我们的研究结果表明,ESWT通过激活PI3K/AKT/FOXO1信号通路,减轻糖皮质激素诱导的bmec损伤和功能障碍。
{"title":"Extracorporeal shock wave therapy alleviates glucocorticoid-induced injury and dysfunction of bone microvascular endothelial cells via the PI3K/AKT/FOXO1 pathway.","authors":"Yu Zhou, Dehui Song, Haoyang Liu, Hongxu Li, Bailiang Wang, Wei Sun","doi":"10.21037/aoj-25-36","DOIUrl":"https://doi.org/10.21037/aoj-25-36","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Glucocorticoid-induced osteonecrosis of the femoral head (ONFH) is a common orthopedic condition with a high disability rate, and its pathogenesis remains incompletely understood. Increasing evidence suggests that glucocorticoid-induced damage and dysfunction of bone microvascular endothelial cells (BMECs) play a crucial role in the development and progression of ONFH. Glucocorticoids can cause damage and apoptosis of vascular endothelial cells, triggering coagulopathy and sustained inflammation. These pathological alterations contribute to thrombosis and microcirculatory disturbances, eventually leading to ischemic ONFH. As a non-invasive treatment modality, extracorporeal shock wave therapy (ESWT) offers several advantages, including its non-invasive nature, adjustable stimulation intensity, low procedural risk, and minimal complications. ESWT has been shown to relieve pain, improve hip joint function, and delay disease progression in ONFH patients. Moreover, several studies have reported that the therapeutic efficacy of ESWT is superior to that of core decompression or core decompression combined with bone grafting. However, the underlying mechanisms of its effectiveness remain unclear. This study aimed to investigate the effects and potential mechanisms of ESWT in an &lt;i&gt;in vitro&lt;/i&gt; model of glucocorticoid-induced BMECs injury.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;An &lt;i&gt;in vitro&lt;/i&gt; model of glucocorticoid-induced injury in BMECs was established, and various intensities of ESWT were applied to determine the optimal treatment parameters. To assess the therapeutic effects of ESWT on glucocorticoid-induced injury in BMECs, cell viability, proliferation, angiogenic capacity, migration, and apoptosis were evaluated using the Cell Counting Kit-8 (CCK-8) assay, 5-ethynyl-2'-deoxyuridine (EdU) incorporation assay, tube formation assay, wound healing and Transwell assays, and Annexin V-fluorescein isothiocyanate (FITC)/propidium iodide (PI) assay, respectively. In addition, Western blot analysis was conducted to examine the expression levels of PI3K, phospho- (p-)PI3K, AKT, p-AKT, FOXO1, and p-FOXO1. The involvement of the PI3K/AKT/FOXO1 signaling pathway in the protective effect of ESWT was further validated using a specific PI3K inhibitor LY294002.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Our study demonstrated that the biological effects of ESWT exhibit a dose-dependent pattern, and 0.06 mJ/mm&lt;sup&gt;2&lt;/sup&gt; with 1,000 pulses may represent the optimal parameter for alleviating glucocorticoid-induced injury in BMECs. ESWT effectively mitigated BMEC injury and dysfunction caused by glucocorticoid exposure, as evidenced by enhanced cell viability, proliferation, angiogenic capacity, and migration ability, as well as reduced apoptosis. Western blot analysis further revealed that ESWT treatment significantly increased the phosphorylation levels of PI3K, AKT, and FOXO1, as indicated by elevated p-PI3K/PI3K, p-AKT/AKT, and p-FOXO1/FOXO1 rat","PeriodicalId":44459,"journal":{"name":"Annals of Joint","volume":"11 ","pages":"5"},"PeriodicalIF":0.9,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Annals of Joint
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1