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Massive pseudotumor of unknown etiology in a cemented metal-on-polyethylene total hip arthroplasty: a case report. 病因不明的骨水泥聚乙烯金属全髋关节置换术大面积假瘤:病例报告。
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2022-10-15 eCollection Date: 2022-01-01 DOI: 10.21037/aoj-22-3
Aaron Gazendam, Karim Masrouha, Snezana Popovic, Michelle Ghert, David Wilson

Background: The formation of destructive pseudotumors is a well-documented, albeit rare, complication of total hip arthroplasties. They tend to be progressive and, if left untreated, can result in extensive periprosthetic bony destruction. The current case presents a large benign mass consistent with a pseudotumor on both imaging and intraoperative findings but histologic findings demonstrating chronic hematoma.

Case description: An 86-year-old female with a metal-on-polyethylene total hip presented with a massive pseudotumor accompanied by extensive bony lysis. Due to pain and chronic anemia, a palliative debulking procedure was undertaken as a palliative measure. At one year follow-up, the patient reported significant pain relief and was able to ambulate safely with gait aids. Her hemoglobin stabilized post-operatively and ongoing transfusions were not required. Final pathology was not supportive of particle disease despite this being the leading diagnosis. Microscopic sections showed tissue mostly composed of fibrin and blood with multiple foci of calcification and reactive papillary endothelial hyperplasia which can be seen in chronic hematomas.

Conclusions: This case presents the diagnostic dilemma of a large benign mass consistent with a pseudotumor on both imaging and intraoperative findings but histologic findings consistent with a chronic hematoma. It highlights the importance of close follow-up and early intervention when periprosthetic osteolysis is detected.

背景:破坏性假瘤的形成是全髋关节置换术的一种并发症,尽管罕见,但已得到充分证实。假瘤往往呈进行性发展,如果不及时治疗,可导致假体周围大面积骨质破坏。本病例中的大块良性肿块在影像学和术中发现均与假瘤一致,但组织学结果显示为慢性血肿:一位86岁的女性患者,其髋关节为金属聚乙烯全髋关节,并伴有巨大的假瘤和广泛的骨质溶解。由于疼痛和慢性贫血,患者接受了姑息性剥脱手术。在一年的随访中,患者表示疼痛明显缓解,并能在步态辅助工具的帮助下安全行走。术后她的血红蛋白趋于稳定,无需继续输血。最终病理结果不支持颗粒疾病,尽管这是主要诊断。显微镜切片显示组织主要由纤维蛋白和血液组成,并伴有多个钙化灶和反应性乳头状内皮增生,这在慢性血肿中很常见:本病例的影像学和术中检查结果均符合假瘤,但组织学检查结果却与慢性血肿一致,这是一个巨大良性肿块的诊断难题。它强调了在发现假体周围溶骨时密切随访和早期干预的重要性。
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引用次数: 0
A narrative review of lateral meniscus transplantation with the bridge in slot: technique and outcomes. 使用槽桥进行外侧半月板移植的叙述性综述:技术和结果。
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2022-04-15 eCollection Date: 2022-01-01 DOI: 10.21037/aoj-20-109
Levy I Nathan, Benjamin S Kester, Nolan B Condron, Aghogho Evuarherhe, Brain J Cole

Objective: This narrative review aims to detail the indications, technique, and published outcomes of the bridge in slot technique for lateral meniscus allograft transplantation (LMAT) and to serve as a concise reference for orthopaedists looking to incorporate this method into their practice.

Background: The menisci are crucial to normal knee function but are commonly injured; partial and subtotal meniscectomy are frequently performed to address meniscal pathology. Following these procedures, a substantial number of patients go on to develop degenerative joint changes accompanied by pain and disability. LMAT is an attractive option for young, active, lateral meniscal-deficient patients who seek pain relief and improved function but who are not yet prepared to undergo arthroplasty. In the properly indicated patient, the bridge in slot technique is a reliable and effective method for LMAT.

Methods: Using a narrative style, this review outlines the indications and preoperative assessment for LMAT, the detailed technical steps for the bridge in slot technique, postoperative considerations, and trends in the surgical outcomes literature. The presented technique is consistent with the senior author's clinical experience and with published literature and the discussed outcomes are elicited from a focused review of recent peer-reviewed sources.

Conclusions: The bridge in slot technique is a reliable and effective method for LMAT and is supported by the literature. This technique may confidently be used in patients with severe lateral meniscal pathology who are not yet candidates for arthroplasty.

目的:这篇叙述性综述旨在详细介绍外侧半月板同种异体移植(LMAT)的适应症、技术和已发表的结果,并为希望将这种方法纳入其临床实践的骨科医生提供简明参考:背景:半月板对膝关节的正常功能至关重要,但却经常受到损伤;为解决半月板病理问题,经常会进行半月板部分切除术和半月板次全切除术。这些手术后,相当多的患者会出现关节退行性病变,并伴有疼痛和残疾。对于年轻、活跃、有外侧半月板缺损的患者来说,LMAT 是一个很有吸引力的选择,因为他们需要缓解疼痛、改善功能,但还没有准备好接受关节成形术。对于有适当适应症的患者,槽桥技术是一种可靠有效的 LMAT 方法:本综述采用叙述的方式,概述了 LMAT 的适应症和术前评估、槽中桥技术的详细技术步骤、术后注意事项以及手术效果文献的趋势。所介绍的技术与资深作者的临床经验和已发表的文献一致,所讨论的结果是通过对近期同行评议资料的重点回顾得出的:槽中桥技术是一种可靠、有效的 LMAT 方法,并得到了文献的支持。结论:槽中桥技术是一种可靠、有效的LMAT方法,并得到了相关文献的支持。对于患有严重外侧半月板病变但尚未进行关节置换术的患者,可以放心地使用这种技术。
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引用次数: 0
Anterior cruciate ligament injury prevention. 预防前十字韧带损伤。
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2022-01-15 eCollection Date: 2022-01-01 DOI: 10.21037/aoj-2020-01
Hannah Bradsell, Rachel M Frank

Anterior cruciate ligament injuries are a prominent issue in the field of sports medicine, especially for the female athlete. Extensive research has been performed that acknowledges the disparity in anterior cruciate ligament injury rates between male and female athletes and the high prevalence of risk factors specific to females. The underlying causes of anterior cruciate ligament injuries are widespread and are important to consider when approaching injury prevention. For example, prevention techniques aim to correct neuromuscular imbalances and improve biomechanical deficits, which are some of the most significant risk factors leading to these injuries. While there is a lack of opportunity for intervention related to anatomical and hormonal risks, awareness of their influence on injury mechanisms remains an important factor in clinical decision-making. In pursuit of addressing the risks of this injury, several prevention programs have been established that have been shown to successfully reduce anterior cruciate ligament injury rates when properly executed. The most effective programs include early intervention with continuous training and are multicomponent programs including various targeted exercises to modify associated risk factors. Unfortunately, despite the development of these readily available programs, anterior cruciate ligament injury rates remain high due to insufficient implementation of these methods. Recognizing the efficacy and feasibility of utilizing prevention strategies and continuing to develop effective techniques remain of utmost importance to reduce the incidence of this substantial injury among athletes.

前十字韧带损伤是运动医学领域的一个突出问题,尤其是对女运动员而言。大量研究表明,男女运动员的前十字韧带损伤率存在差异,女性特有的风险因素也很普遍。前十字韧带损伤的根本原因十分广泛,在预防损伤时必须加以考虑。例如,预防技术旨在纠正神经肌肉失衡和改善生物力学缺陷,这些都是导致这些损伤的一些最重要的风险因素。虽然缺乏对解剖学和荷尔蒙风险进行干预的机会,但认识到它们对损伤机制的影响仍然是临床决策的一个重要因素。为了应对这种损伤的风险,已经制定了几项预防计划,只要执行得当,这些计划都能成功降低前十字韧带损伤率。最有效的计划包括早期干预和持续训练,并且是多成分计划,包括各种有针对性的练习,以改变相关的风险因素。遗憾的是,尽管制定了这些现成的计划,但由于这些方法实施不足,前十字韧带损伤率仍然居高不下。认识到利用预防策略的有效性和可行性,并继续开发有效的技术,对于降低运动员中这一重大损伤的发生率仍然至关重要。
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引用次数: 0
The multidisciplinary approach to managing prosthetic joint infection: could this lead to improved outcomes? 假体关节感染的多学科管理方法:能否改善疗效?
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2022-01-15 eCollection Date: 2022-01-01 DOI: 10.21037/aoj-2020-04
Nemandra A Sandiford, Konrad Wronka

Periprosthetic joint infection (PJI) is a devastating complication of the total joint arthroplasty (TJA). It presents a great challenge for the treating clinician. Diagnosis as well as management can prove difficult with significant morbidity for the patients and cost for patients, health care providers and society as a whole. Outcomes of equally challenging pathology such as tumors and polytrauma have been shown to be improved when patients are managed by a team as specialists as opposed to single individuals. The purpose of this study is to review the role of the multi-disciplinary team (MDT) approach in the diagnosis and management of PJI. We examine the influence of this approach on clinical outcomes in patients with PJI. We also discuss the organisational and logistical issues associated with establishment of a MDT as well as several other issues not mentioned in the contemporary orthopaedic literature. All published literature examining the role of multidisciplinary care in the management of PJI and the influence of this approach to the management and outcomes of patients with this diagnosis were included. Studies published in languages other than English were excluded. There is a paucity of data on the influence of multidisciplinary care on outcomes of the management of PJI. Evidence suggests that the MDT has important role in ensuring all factors in the management of this complex group are considered and best possible care is delivered. Multicentre randomised clinical trials are required to assess the influence of MDT'S on outcome as well as important questions around the structuring of these teams.

假体周围关节感染(PJI)是全关节成形术(TJA)的一种破坏性并发症。它给临床医生带来了巨大的挑战。诊断和治疗都很困难,患者的发病率很高,患者、医疗服务提供者和整个社会的成本也很高。事实证明,与单个个体相比,如果由一个专家团队对患者进行管理,同样具有挑战性的病理(如肿瘤和多发性创伤)的治疗效果会得到改善。本研究旨在回顾多学科团队(MDT)方法在 PJI 诊断和管理中的作用。我们研究了这种方法对 PJI 患者临床疗效的影响。我们还讨论了与建立多学科团队相关的组织和后勤问题,以及当代骨科文献中未提及的其他一些问题。我们纳入了所有已发表的文献,这些文献研究了多学科护理在PJI管理中的作用,以及这种方法对该诊断患者的管理和治疗效果的影响。除英语外,其他语言发表的研究均被排除在外。有关多学科治疗对 PJI 治疗效果的影响的数据很少。有证据表明,多学科治疗小组在确保对这一复杂群体进行管理时考虑到所有因素并提供最佳治疗方面发挥着重要作用。需要进行多中心随机临床试验,以评估 MDT 对疗效的影响,以及围绕这些团队结构的重要问题。
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引用次数: 0
The female athlete triad. 女运动员的三要素
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2022-01-15 eCollection Date: 2022-01-01 DOI: 10.21037/aoj-2020-03
Amanda Weiss Kelly, Suzanne Hecht

The female athlete triad represents the 3 interrelated components: of energy availability (EA), menstrual function and bone health. Each component exists on a spectrum ranging from optimal health to dysfunction. Screening for the triad during the annual wellness exam, the preparticipation physical evaluation (PPE) or when the athlete presents with any single component can help identify athletes at risk. A multidisciplinary team is helpful in managing the treatment of the Triad which relies on improving EA. Screening, early recognition and aggressive treatment is important, especially in adolescent athletes to optimize bone health.

女运动员三要素代表了三个相互关联的组成部分:能量供应(EA)、月经功能和骨骼健康。每个组成部分都存在于从最佳健康到功能障碍的范围内。在年度健康检查、参赛前体能评估(PPE)或运动员出现任何单项问题时进行三联征筛查,有助于识别高危运动员。多学科团队有助于管理三联症的治疗,这有赖于改善 EA。筛查、早期识别和积极治疗对优化骨骼健康非常重要,尤其是对青少年运动员。
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引用次数: 0
Evaluation and management of patellar instability. 髌骨不稳的评估和治疗。
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2022-01-15 eCollection Date: 2022-01-01 DOI: 10.21037/aoj-2020-02
Elizabeth R Dennis, Simone Gruber, William A Marmor, Beth E Shubin Stein

Patellar instability is a common clinical problem that primarily affects the adolescent and young adult population. The demographic and anatomic risk factors that predispose patients to patellar instability are multifactorial and include young age, female sex, trochlear dysplasia, elevated tibial tubercle to trochlear groove distance (TT-TG), patella alta, femoral and tibial malalignment, ligamentous laxity, and lack of neuromuscular control. There have been substantial efforts to predict which patients who sustain a first-time dislocation will go on to incur additional dislocations. This is particularly important because with each dislocation event, there is a significant risk of injury to the patellofemoral joint including both medial patellofemoral ligament (MPFL) stretch or rupture and damage to the cartilage which can range from simple fissures to full-thickness cartilage defects and osteochondral fractures. Prediction models have demonstrated that amongst first time dislocators, young patients with trochlear dysplasia are at the highest risk for redislocation. The current standard of care for treatment of first-time dislocators without a loose body or osteochondral fracture is nonoperative management. However, recently there has been a focus on implementing a risk-stratified approach to the surgical indications for a first-time dislocator as the high-risk population might be better treated with early surgical stabilization to prevent or reduce their risk of recurrent dislocation and its associated morbidity. Likewise, for patients with recurrent dislocations, it remains to be determined whether an isolated MPFL reconstruction is sufficient for high-risk patients with several poor prognostic risk factors or if bony realignment procedures should be implemented concurrently.

髌骨不稳是一种常见的临床问题,主要影响青少年和年轻成年人。导致患者髌骨不稳的人口和解剖风险因素是多方面的,包括年龄小、女性、蹄铁发育不良、胫骨结节与蹄铁沟距离(TT-TG)增高、髌骨突出、股骨和胫骨错位、韧带松弛以及缺乏神经肌肉控制。人们一直在努力预测哪些首次脱位的患者会继续发生脱位。这一点尤为重要,因为每次脱位都会给髌股关节带来巨大的损伤风险,包括髌股关节内侧韧带(MPFL)拉伸或断裂,以及软骨损伤(从简单的裂缝到全厚软骨缺损和骨软骨骨折)。预测模型显示,在首次脱位的患者中,患有趾骨发育不良的年轻患者再次脱位的风险最高。对于没有松动体或骨软骨骨折的首次脱位患者,目前的治疗标准是采用非手术疗法。然而,最近人们开始关注对初次脱位者的手术适应症实施风险分级的方法,因为高风险人群可能更适合早期手术稳定治疗,以预防或降低其复发性脱位的风险及其相关发病率。同样,对于复发性脱位患者,对于具有多种不良预后风险因素的高危患者,孤立的MPFL重建是否足够,或者是否应同时实施骨性复位手术,仍有待确定。
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引用次数: 0
In memory of Freddie Fu, AOJ’s Honorary Editor-in-Chief and renowned Pitt surgeon 为纪念《美国医学杂志》名誉总编辑、著名皮特外科医生傅福烈
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2021-10-01 DOI: 10.21037/aoj-2021-01
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引用次数: 0
Biofilm formation in periprosthetic joint infections. 假体周围关节感染的生物膜形成。
IF 0.5 4区 医学 Q4 ORTHOPEDICS Pub Date : 2021-10-01 Epub Date: 2021-10-15 DOI: 10.21037/aoj-20-85
Amelia Staats, Daniel Li, Anne C Sullivan, Paul Stoodley

Formation of microbial biofilms has long been implicated in the occurrence of periprosthetic joint infections (PJIs). Despite the widespread acknowledgment of the severity of these infections, much is still unknown regarding the underlying mechanisms of biofilm establishment and proliferation in the joint space. The presence of these resilient, complex communities poses many clinical challenges with respect to prevention, diagnosis, and treatment practices. Mature biofilms are known to be highly recalcitrant to antibiotic therapeutics as well as host immune system mediated clearance. A comprehensive understanding of biofilms in the unique joint environment at the molecular level will provide clinicians valuable insight into how best to combat them. As each stage in the process of biofilm establishment has the potential for clinical intervention, this review will provide a sequential analysis of the existing literature, following each step in the formation cycle. New insights into bacterial survival mechanisms from antimicrobial challenge and host immune defenses will be discussed. These new observations in the field may shed light on the early protection conferred upon entry into the joint space ultimately leading to the establishment of a mature biofilm. Additionally, standards of clinical diagnosis as well as current measures of prevention and treatment will be briefly discussed.

长期以来,微生物生物膜的形成一直与假体周围关节感染(PJIs)的发生有关。尽管人们普遍认识到这些感染的严重性,但对于生物膜在关节间隙建立和增殖的内在机制仍有许多未知之处。这些富有弹性的复杂群落的存在给预防、诊断和治疗方法带来了许多临床挑战。众所周知,成熟的生物膜对抗生素疗法和宿主免疫系统介导的清除非常不敏感。从分子水平全面了解独特关节环境中的生物膜,将为临床医生提供宝贵的见解,帮助他们了解如何以最佳方式对抗生物膜。由于生物膜形成过程中的每个阶段都有可能进行临床干预,本综述将按照形成周期的每个步骤对现有文献进行顺序分析。将讨论从抗菌挑战和宿主免疫防御机制中了解细菌生存机制的新见解。这些新的观察结果可能会揭示细菌进入关节间隙并最终形成成熟生物膜的早期保护机制。此外,还将简要讨论临床诊断标准以及当前的预防和治疗措施。
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引用次数: 0
Can the Katagiri scoring system predict prognosis for surgically-managed patients with metastatic bone disease? Katagiri评分系统能预测手术治疗的转移性骨病患者的预后吗?
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2021-06-11 DOI: 10.21037/AOJ-20-111
E. Uğur, H. Doshi, S. Wilson, Nicole L. Levine, Janet Tingling, Rachel Y. Yang, B. Hoang, D. Geller, Rui Yang
The Albert Einstein College of Medicine, Bronx, NY, USA; Department of Orthopaedic Surgery, Montefiore Medical Center, Bronx, NY, USA; Hunter College High School, New York, NY, USA Contributions: (I) Concept and design: R Yang, BH Hoang, DS Geller; (II) Administrative support: R Yang, BH Hoang, DS Geller; (III) Provision of study materials or patients: H Doshi, E Ugur, NL Levine; (IV) Collection and assembly of data: H Doshi, E Ugur, NL Levine, S Wilson, J Tingling, RY Yang; (V) Data analysis and interpretation: H Doshi, E Ugur, NL Levine, S Wilson, J Tingling, RY Yang; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Rui Yang, MD. Department of Orthopaedic Surgery, Montefiore Medical Center, 3400 Bainbridge Avenue, 6th floor, Bronx, NY 10467, USA. Email: ryan@montefiore.org.
阿尔伯特·爱因斯坦医学院,美国纽约州布朗克斯;美国纽约布朗克斯蒙蒂菲奥里医疗中心整形外科;Hunter College High School,New York,NY,USA贡献:(I)概念与设计:R Yang,BH Hoang,DS Geller;(II) 行政支持:R Yang,BH Hoang,DS Geller;(III) 提供研究材料或患者:H Doshi、E Ugur、NL Levine;(IV) 数据收集和汇编:H Doshi、E Ugur、NL Levine、S Wilson、J Tingling、RY Yang;(V) 数据分析与解释:H Doshi,E Ugur,NL Levine,S Wilson,J Tingling,RY Yang;(VI) 手稿写作:所有作者;(VII) 手稿的最终批准:所有作者。通讯地址:Rui Yang,医学博士。美国纽约州布朗克斯市班布里奇大道3400号蒙蒂菲奥里医疗中心骨科,邮编:10467。电子邮件:ryan@montefiore.org.
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引用次数: 0
Comparison and modification of survival predicting system for breast cancer patients with bone metastases 乳腺癌骨转移患者生存预测系统的比较与改进
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2021-05-18 DOI: 10.21037/AOJ-20-120
W. Du, Jichuan Wang, Jie Xu, Zhiqing Zhao, Siyao Liu, Liu Yang, Rui Yang, Shu Wang, Weiling Guo
Background: Breast cancer is the most common malignancy in the female. Survival for patients with breast cancer has improved substantially over the past two decades, accompanied by increased patients with skeletal-related events. Since surgery is most commonly needed for complete or pending pathological fractures, an accurate preoperative survival estimation for patients with symptomatic bone metastases is crucial in surgical decision making. Several prognostic models for survival estimation in metastatic cancer patients have been developed in western centers without external validation in Asian patient populations and breast cancer-specific cohorts. Methods: Seven survival prediction models were externally validated by a cohort of metastatic breast cancer patients from an Asian center. The prediction ability and accuracy were valued using receiver operating characteristic analysis and Brier score at different time points. Univariate and multivariate Cox regression was used to identify independent prognostic factors. A multivariable prediction model was further established and validated. Results: In our metastatic breast cancer patients cohort, the PathFx model demonstrated superior accuracy at predicting 3- and 6-month survival while the SSG model showed the highest accuracy at 12-month. None of these models exhibit accurate predictions beyond 12-month. Cox regression further identified five independent prognostic factors. A prognostic scoring system with breast cancer-specific prognostic factors was established. Internal validation showed consistent discrimination and accuracy. Conclusions: Current prognostic models showed inconsistent and limited accuracy in Asian metastatic breast cancer patients, especially for more prolonged estimated survival. A disease-based predicting model with cancer-specific prognostic factors would increase the prediction accuracy and help with surgical decision making.
背景:乳腺癌是女性最常见的恶性肿瘤。在过去的二十年中,乳腺癌患者的生存率大大提高,同时伴有骨骼相关事件的患者也在增加。由于完全性或待决的病理性骨折最常需要手术,因此对有症状的骨转移患者进行准确的术前生存评估对于手术决策至关重要。一些转移性癌症患者生存评估的预后模型已经在西方中心开发出来,但没有在亚洲患者群体和乳腺癌特异性队列中进行外部验证。方法:来自亚洲中心的转移性乳腺癌患者队列对七个生存预测模型进行了外部验证。采用不同时间点的受试者工作特征分析和Brier评分对预测能力和准确性进行评价。采用单因素和多因素Cox回归来确定独立的预后因素。进一步建立并验证了多变量预测模型。结果:在我们的转移性乳腺癌患者队列中,PathFx模型在预测3个月和6个月生存率方面表现出更高的准确性,而SSG模型在预测12个月生存率方面表现出最高的准确性。这些模型都不能准确预测12个月以后的情况。Cox回归进一步确定了5个独立的预后因素。建立了具有乳腺癌特异性预后因素的预后评分系统。内部验证表明鉴别和准确性一致。结论:目前的预后模型在亚洲转移性乳腺癌患者中显示出不一致和有限的准确性,特别是对于更长的估计生存期。结合肿瘤特异性预后因素的基于疾病的预测模型将提高预测的准确性并有助于手术决策。
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引用次数: 0
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