DOI: 10.4328/JCAM.6202 Received: 07.02.2019 Accepted: 17.02.2019 Published Online: 18.02.2019 Printed: 01.05.2019 J Clin Anal Med 2019;10(3): 402-7 Corresponding Author: Nurcan Akbaş Güneş, Yeni Family Health Center, Eskişehir, Turkey. GSM: +905054929074 E-Mail: drnurak@hotmail.com ORCID ID: 0000-0001-8688-5839 Abstract Aim: In this study, we aimed to assess the incidence of postpartum depression, factors affecting the development of postpartum depression and to make a detailed analysis of intimate partner violence (IPV) during pregnancy and its effects on postpartum depression. Material and Method: This study enrolled 220 participants who were 2-6 months in puerperiumperiod. The ssociodemographic features of the participants and the levels of physical, economic, sexual, and psychological IPV exposed during pregnancy were rated using Edinburgh Postpartum Depression Scale (EPDS) that determines the risk of postpartum depression. A p-value less than 0.05 was considered statistically significant. Results: The mean age of 220 participants was 30.84±6.032 years. Thirty-five (15.9%) participants scored 13 or higher in the EPDS score; these 35 participants were considered to have postpartum depression (PPD). There was a significant difference between the EPDS scores by the educational levels of the partners (p<0.05). EPDS score was affected significantly by having a delivery under urgent conditions, developing any infantile complication during delivery, physical and psychological IPV had a significant effect on EPDS (p<0.05). Marriage age and educational level had a significant correlation with physical IPV (p<0.05). Discussion: PPD is a highly prevalent disorder that adversely affects the quality of life of a mother, infant, and all family members. Mothers in the postpartum period should be more closely followed and PPD must be questioned in family health centers.
{"title":"The relationship of postpartum depression with sociodemographic factors","authors":"Nurcan Akbaş Güneş","doi":"10.4328/JCAM.6202","DOIUrl":"https://doi.org/10.4328/JCAM.6202","url":null,"abstract":"DOI: 10.4328/JCAM.6202 Received: 07.02.2019 Accepted: 17.02.2019 Published Online: 18.02.2019 Printed: 01.05.2019 J Clin Anal Med 2019;10(3): 402-7 Corresponding Author: Nurcan Akbaş Güneş, Yeni Family Health Center, Eskişehir, Turkey. GSM: +905054929074 E-Mail: drnurak@hotmail.com ORCID ID: 0000-0001-8688-5839 Abstract Aim: In this study, we aimed to assess the incidence of postpartum depression, factors affecting the development of postpartum depression and to make a detailed analysis of intimate partner violence (IPV) during pregnancy and its effects on postpartum depression. Material and Method: This study enrolled 220 participants who were 2-6 months in puerperiumperiod. The ssociodemographic features of the participants and the levels of physical, economic, sexual, and psychological IPV exposed during pregnancy were rated using Edinburgh Postpartum Depression Scale (EPDS) that determines the risk of postpartum depression. A p-value less than 0.05 was considered statistically significant. Results: The mean age of 220 participants was 30.84±6.032 years. Thirty-five (15.9%) participants scored 13 or higher in the EPDS score; these 35 participants were considered to have postpartum depression (PPD). There was a significant difference between the EPDS scores by the educational levels of the partners (p<0.05). EPDS score was affected significantly by having a delivery under urgent conditions, developing any infantile complication during delivery, physical and psychological IPV had a significant effect on EPDS (p<0.05). Marriage age and educational level had a significant correlation with physical IPV (p<0.05). Discussion: PPD is a highly prevalent disorder that adversely affects the quality of life of a mother, infant, and all family members. Mothers in the postpartum period should be more closely followed and PPD must be questioned in family health centers.","PeriodicalId":44485,"journal":{"name":"Journal of Clinical and Analytical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45141879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmet Yılmaz1, İlyas Yolbas2, Hatice Yılmaz3, Gamze Bucaktepe4, Ünal Uluca5, Fesih Aktar2, Sabahattin Ertugrul2 1Department of Family Medicine, Dicle University Medical Faculty, Diyarbakir, 2Department of Pediatric, Dicle University Medical Faculty, Diyarbakir, 3Gazi Yasargil Educational Research Hospital, Diyarbakir, 4Bingol Public Health And Safety Unit, Bingol, 5Memorial Hospital, Diyarbakir, Turkey Fetomaternal and obstetric outcomes of advanced maternal age Attention for fetomaternal and obstetric outcomes of advanced maternal age: a broad range clinical evaluation
Ahmet Yılmaz1， İlyas Yolbas2, Hatice Yılmaz3, Gamze buaktepe4， Ünal Uluca5, Fesih Aktar2, Sabahattin Ertugrul2 1迪亚尔巴克尔迪克尔大学医学院家庭医学系，2迪亚尔巴克尔迪克尔大学医学院儿科学系，3迪亚尔巴克尔gazi Yasargil教育研究医院，4Bingol Bingol公共卫生与安全部门，5迪亚尔巴克尔纪念医院，高龄产妇的胎母和产科结局关注高龄产妇的胎母和产科结局:广泛的临床评估
{"title":"Attention for fetomaternal and obstetric outcomes of advanced maternal age: a broad range clinical evaluation","authors":"A. Yilmaz","doi":"10.4328/JCAM.5903","DOIUrl":"https://doi.org/10.4328/JCAM.5903","url":null,"abstract":"Ahmet Yılmaz1, İlyas Yolbas2, Hatice Yılmaz3, Gamze Bucaktepe4, Ünal Uluca5, Fesih Aktar2, Sabahattin Ertugrul2 1Department of Family Medicine, Dicle University Medical Faculty, Diyarbakir, 2Department of Pediatric, Dicle University Medical Faculty, Diyarbakir, 3Gazi Yasargil Educational Research Hospital, Diyarbakir, 4Bingol Public Health And Safety Unit, Bingol, 5Memorial Hospital, Diyarbakir, Turkey Fetomaternal and obstetric outcomes of advanced maternal age Attention for fetomaternal and obstetric outcomes of advanced maternal age: a broad range clinical evaluation","PeriodicalId":44485,"journal":{"name":"Journal of Clinical and Analytical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43842845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hurry Up! If not treated, Mucormycosis is lethal","authors":"Selçuk Nazik","doi":"10.4328/JCAM.5904","DOIUrl":"https://doi.org/10.4328/JCAM.5904","url":null,"abstract":"","PeriodicalId":44485,"journal":{"name":"Journal of Clinical and Analytical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47135024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yeliz Mercan1, Seniha Bilge Hapcıoglu2, Halim Issever2 1Department of Health Management School of Health, Kırklareli University, Kırklareli, 2Department of Public Health, Faculty of Medicine, Istanbul University, Istanbul, Turkey Time series analysis of the admission to emergency department Time series analysis of the admission to the emergency department due to respiratory and cardiovascular diseases between 2010 and 2014 in Kırklareli, Turkey
{"title":"Time series analysis of the admission to the emergency department due to respiratory and cardiovascular diseases between 2010 and 2014 in Kırklareli, Turkey","authors":"Yeliz Mercan","doi":"10.4328/JCAM.6113","DOIUrl":"https://doi.org/10.4328/JCAM.6113","url":null,"abstract":"Yeliz Mercan1, Seniha Bilge Hapcıoglu2, Halim Issever2 1Department of Health Management School of Health, Kırklareli University, Kırklareli, 2Department of Public Health, Faculty of Medicine, Istanbul University, Istanbul, Turkey Time series analysis of the admission to emergency department Time series analysis of the admission to the emergency department due to respiratory and cardiovascular diseases between 2010 and 2014 in Kırklareli, Turkey","PeriodicalId":44485,"journal":{"name":"Journal of Clinical and Analytical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41744216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Onder Ozcan1, Ahmet Korkut Belli1, Selami Ilgaz Kayilioglu1, Cem Donmez1, Ozgur Ilhan Celik2, Mehmet Kaplan3, Murat Kara4, Murat Polat1 1Department of General Surgery, School of Medicine, Muğla Sıtkı Koçman University, Muğla, 2Department of Pathology, Mugla Sitki Kocman University Medical School, Mugla, 3Department of General Surgery, NCR International Hospital, Gaziantep, 4Medical Genetics Specialist, MD, Self-Employment, Mersin, Turkey RUNX genes in breast cancer and fibroadenoma RUNX genes expressions in breast cancer and fibroadenoma
Onder Ozcan1, Ahmet Korkut Belli1, Selami Ilgaz Kayilioglu1, Cem Donmez1, Ozgur Ilhan Celik2, Mehmet Kaplan3, Murat kar4, Murat Polat1 1医学院普通外科，Muğla Sıtkı科帕尔曼大学，Muğla, 2 Mugla Sitki Kocman大学医学院病理学系，Mugla, 3普通外科，NCR国际医院，加济安特普，4医学遗传学专家，医学博士，自创业，Mersin，RUNX基因在乳腺癌和纤维腺瘤中的表达
{"title":"RUNX genes expressions in breast cancer and fibroadenoma","authors":"O. Ozcan","doi":"10.4328/JCAM.6099","DOIUrl":"https://doi.org/10.4328/JCAM.6099","url":null,"abstract":"Onder Ozcan1, Ahmet Korkut Belli1, Selami Ilgaz Kayilioglu1, Cem Donmez1, Ozgur Ilhan Celik2, Mehmet Kaplan3, Murat Kara4, Murat Polat1 1Department of General Surgery, School of Medicine, Muğla Sıtkı Koçman University, Muğla, 2Department of Pathology, Mugla Sitki Kocman University Medical School, Mugla, 3Department of General Surgery, NCR International Hospital, Gaziantep, 4Medical Genetics Specialist, MD, Self-Employment, Mersin, Turkey RUNX genes in breast cancer and fibroadenoma RUNX genes expressions in breast cancer and fibroadenoma","PeriodicalId":44485,"journal":{"name":"Journal of Clinical and Analytical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44234733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
DOI: 10.4328/JCAM.6155 Received: 07.01.2019 Accepted: 14.01.2019 Published Online: 14.01.2019 Printed: 01.05.2019 J Clin Anal Med 2019;10(3): 394-7 Corresponding Author: Ebru Kuyumcu Savan, Faculty of Pharmacy, Analytical Chemistry Division, İnönü University, Malatya, Turkey. T.: +90 4223411216 F.: +90 4223411217 E-Mail: ebru.savan@inonu.edu.tr ORCID ID: 0000-0002-8851-0907 Abstract Aim: In this study, it was aimed to determine the reduced Glutathione (GSH) at the modified sensor with a simple and reliable electroanalytical method. Material and Method: Cyclic voltammetry and differential pulse voltammetry techniques were used for the determination of reduced-GSH. And the modified sensor was fabricated by dropping single-walled carbon nanotube (SWCNT) dispersion onto the surface of the glassy carbon electrode. Results: The determination of reduced-GSH was accomplished at SWCNT modified sensor. The relationship between the current responses of the sensor and the concentrations of the reduced-GSH (1.0 x 10-8 5.0 x 10-8 M) showed excellent linearity and the detection limit was calculated as 75 nM. Discussion: Determination of trace amounts of reduced-GSH in urine samples was successfully applied at the modified sensor. The results showed that modification of the glassy carbon electrode with SWCNT could provide a new strategy for determining the concentration of GSH in physiological solutions.
DOI:10.4328/JCAM.6155接收日期：2019年1月7日接受日期：2019年底1月14日在线发布日期：2019年初1日印刷日期：2019年月1日《临床分析医学杂志》；10（3）：394-7通讯作者：Ebru Kuyumcu Savan，土耳其马拉蒂亚伊恩努大学分析化学系药学院。电话：+90 4223411216传真：+90 422 3411217电子邮箱：ebru.savan@inonu.edu.trORCID ID:0000-0002-8851-0907摘要目的：本研究旨在用一种简单可靠的电分析方法测定改良传感器中还原的谷胱甘肽（GSH）。材料与方法：采用循环伏安法和微分脉冲伏安法测定还原态谷胱甘肽。通过将单壁碳纳米管（SWCNT）分散体滴加到玻碳电极表面，制备了改进的传感器。结果：在SWCNT修饰的传感器上完成了还原GSH的测定。传感器的电流响应与还原的GSH浓度（1.0 x 10-8 5.0 x 10-8M）之间的关系显示出极好的线性，检测限计算为75nM。讨论：在改进的传感器上成功地应用了尿样品中微量还原GSH的测定。结果表明，SWCNT修饰玻碳电极可以为测定生理溶液中GSH的浓度提供一种新的策略。
{"title":"Electroanalytical determination of reduced-glutathione in biological samples","authors":"E. Savan","doi":"10.4328/JCAM.6155","DOIUrl":"https://doi.org/10.4328/JCAM.6155","url":null,"abstract":"DOI: 10.4328/JCAM.6155 Received: 07.01.2019 Accepted: 14.01.2019 Published Online: 14.01.2019 Printed: 01.05.2019 J Clin Anal Med 2019;10(3): 394-7 Corresponding Author: Ebru Kuyumcu Savan, Faculty of Pharmacy, Analytical Chemistry Division, İnönü University, Malatya, Turkey. T.: +90 4223411216 F.: +90 4223411217 E-Mail: ebru.savan@inonu.edu.tr ORCID ID: 0000-0002-8851-0907 Abstract Aim: In this study, it was aimed to determine the reduced Glutathione (GSH) at the modified sensor with a simple and reliable electroanalytical method. Material and Method: Cyclic voltammetry and differential pulse voltammetry techniques were used for the determination of reduced-GSH. And the modified sensor was fabricated by dropping single-walled carbon nanotube (SWCNT) dispersion onto the surface of the glassy carbon electrode. Results: The determination of reduced-GSH was accomplished at SWCNT modified sensor. The relationship between the current responses of the sensor and the concentrations of the reduced-GSH (1.0 x 10-8 5.0 x 10-8 M) showed excellent linearity and the detection limit was calculated as 75 nM. Discussion: Determination of trace amounts of reduced-GSH in urine samples was successfully applied at the modified sensor. The results showed that modification of the glassy carbon electrode with SWCNT could provide a new strategy for determining the concentration of GSH in physiological solutions.","PeriodicalId":44485,"journal":{"name":"Journal of Clinical and Analytical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49500339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gonul Guvenc1, Ceren Kızmazoglu2, Hasan Emre Aydın3, Ege Coskun2 1Department of Neurosurgery, Katip Celebi University Ataturk Research and Training Hospital, Izmir, 2Department of Neurosurgery, Dokuz Eylül University School of Medicine, Izmir, 3Department of Neurosurgery, Dumlupınar Unıversity Evliya Çelebi Training and Research Hospital, Kütahya, Turkey Somatosensory evoked potentials in chiari malformation Somatosensory evoked potentials and cerebrospinal fluid flow in chiari malformation
Gonul Guvenc1, Ceren Kızmazoglu2, Hasan Emre Aydın3, Ege Coskun2 1 Katip Celebi大学阿塔图尔克研究与培训医院神经外科，伊兹密尔，2 Dokuz eyyl大学医学院，伊兹密尔，3神经外科，Dumlupınar Unıversity Evliya Çelebi土耳其k塔哈亚培训与研究医院，chari畸形的体感诱发电位和脑脊液流量
{"title":"Somatosensory evoked potentials and cerebrospinal fluid flow in chiari malformation","authors":"G. Guvenc","doi":"10.4328/JCAM.5913","DOIUrl":"https://doi.org/10.4328/JCAM.5913","url":null,"abstract":"Gonul Guvenc1, Ceren Kızmazoglu2, Hasan Emre Aydın3, Ege Coskun2 1Department of Neurosurgery, Katip Celebi University Ataturk Research and Training Hospital, Izmir, 2Department of Neurosurgery, Dokuz Eylül University School of Medicine, Izmir, 3Department of Neurosurgery, Dumlupınar Unıversity Evliya Çelebi Training and Research Hospital, Kütahya, Turkey Somatosensory evoked potentials in chiari malformation Somatosensory evoked potentials and cerebrospinal fluid flow in chiari malformation","PeriodicalId":44485,"journal":{"name":"Journal of Clinical and Analytical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48741154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
DOI: 10.4328/JCAM.5898 Received: 04.05.2018 Accepted: 16.05.2018 Publihed Online: 16.05.2018 Printed: 01.05.2019 J Clin Anal Med 2019;10(3): 408-10 Corresponding Author: Recep Bedir, Department of Pathology, Recep Tayyip Erdogan University of Medical Faculty, Rize, Turkey. GSM: +905057331695 T.: +90 4642130491 E-Mail: bedirrecep@gmail.com ORCID ID: 0000-0001-8247-3781 Abstract Mucin is a high molecular weight glycoprotein that is secreted by epithelia. In contrast to the common finding of mucin secretion in non-endocrine epithelial tumors, in endocrine tumors it is a very rare finding. Mucin secretion is very rare among the thyroid tumors. In the studies carried out on classifying the thyroid carcinomas in recent years, it was reported that the mucin might be secreted in thyroid carcinomas. In this paper, we present a rarely-seen follicular variant of papillary carcinoma secreting mucin.
{"title":"Mucin-secreting encapsulated follicular variant of thyroid papillary carcinoma: a case report","authors":"R. Bedir","doi":"10.4328/JCAM.5898","DOIUrl":"https://doi.org/10.4328/JCAM.5898","url":null,"abstract":"DOI: 10.4328/JCAM.5898 Received: 04.05.2018 Accepted: 16.05.2018 Publihed Online: 16.05.2018 Printed: 01.05.2019 J Clin Anal Med 2019;10(3): 408-10 Corresponding Author: Recep Bedir, Department of Pathology, Recep Tayyip Erdogan University of Medical Faculty, Rize, Turkey. GSM: +905057331695 T.: +90 4642130491 E-Mail: bedirrecep@gmail.com ORCID ID: 0000-0001-8247-3781 Abstract Mucin is a high molecular weight glycoprotein that is secreted by epithelia. In contrast to the common finding of mucin secretion in non-endocrine epithelial tumors, in endocrine tumors it is a very rare finding. Mucin secretion is very rare among the thyroid tumors. In the studies carried out on classifying the thyroid carcinomas in recent years, it was reported that the mucin might be secreted in thyroid carcinomas. In this paper, we present a rarely-seen follicular variant of papillary carcinoma secreting mucin.","PeriodicalId":44485,"journal":{"name":"Journal of Clinical and Analytical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43667090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
DOI: 10.4328/JCAM.5937 Received: 17.06.2018 Accepted: 11.07.2018 Published Online: 17.07.2018 Printed: 01.05.2019 J Clin Anal Med 2019;10(3): 376-8 Corresponding Author: Seher Erdoğan, Umraniye Research and Training Hospital, Adem Yavuz Cad. No:1, 34764, Ümraniye, İstanbul, Türkiye. GSM: +905326678370 E-Mail: seher70@gmail.com ORCID ID: 0000-0002-3393-3363 Abstract Aim: Therapeutic plasma exchange (TPE) is an extracorporeal treatment technique that allows the removal of unwanted substances with large molecule weight from the blood. In this study, it was aimed to retrospectively assess patients who underwent therapeutic plasmapheresis. Material and Method: The medical data of patients who underwent TPE in the 10-bed pediatric intensive care unit of Ümraniye TRH between May 2017 and May 2018 were retrospectively assessed. Age, sex, body weight, plasmapheresis indications, plasmapheresis technique, complication and mortality rates were recorded. Results: TPE was performed in a total of 19 patients. The mean age of the study population was 8.8 ± 5.9 years. Ten (52.6%) patients were provided respiratory support with mechanical ventilator; the mean duration of ventilator support for these patients was 10.3 ± 10 days. The most common indication for TPE was autoimmune encephalitis with a rate of 42% (8/19 patients); the other indications were: collagen tissue disorder activation, hepatic failure, mitochondriopathic encephalopathy, Guillain-Barre syndrome, septic shock, and hemophagocytic syndrome. The patients were administered totally 5.94 ± 1.69 sessions of TPE, min 3-max 8). As a replacement fluid, fresh frozen plasma (FFP) was used in 17 patients and albumin in 2 patients. The most common complication was catheter-related complications. None of the patients died during the procedure. One patient was followed up for Hashimoto encephalitis and another patient who was followed up for septic shock died. Discussion: TPE is a treatment method that is invasive but with low-side effect profile; it is used to stop disease progression in lifethreatening autoimmune disorders unresponsive to a medical treatment.
DOI: 10.4328 / JCAM.5937收稿日期:17.06.2018收稿日期:11.07.2018出版日期:17.07.2018印刷日期:01.05.2019 J clinical Anal Med 2019;10(3): 376-8通讯作者:Seher Erdoğan, Umraniye Research and Training Hospital, Adem Yavuz Cad。编号:1,34764，Ümraniye， İstanbul, t rkiye。摘要目的:治疗性血浆交换(TPE)是一种体外治疗技术，可以去除血液中不需要的大分子物质。在这项研究中，旨在回顾性评估接受治疗性血浆置换的患者。材料与方法:回顾性分析2017年5月至2018年5月在Ümraniye TRH 10床儿科重症监护室接受TPE的患者的医疗资料。记录年龄、性别、体重、血浆摘取适应症、血浆摘取技术、并发症和死亡率。结果:共19例患者行TPE。研究人群的平均年龄为8.8±5.9岁。10例(52.6%)患者使用机械呼吸机进行呼吸支持;患者呼吸机支持的平均持续时间为10.3±10天。TPE最常见的适应症是自身免疫性脑炎，发生率为42%(8/19例);其他适应症包括:胶原组织紊乱激活、肝功能衰竭、线粒体性脑病、格林-巴利综合征、感染性休克和噬血细胞综合征。患者共接受了5.94±1.69次TPE治疗(最小3-最大8次)，17例患者使用了新鲜冷冻血浆(FFP)作为替代液体，2例患者使用了白蛋白。最常见的并发症是导管相关并发症。没有患者在手术过程中死亡。1例因桥本脑炎随访，1例因感染性休克随访死亡。讨论:TPE是一种有创但副作用低的治疗方法;它用于阻止对药物治疗无反应的危及生命的自身免疫性疾病的疾病进展。
{"title":"Assessment of patients undergoing therapeutic plasmapheresis","authors":"Seher Erdoğan","doi":"10.4328/JCAM.5937","DOIUrl":"https://doi.org/10.4328/JCAM.5937","url":null,"abstract":"DOI: 10.4328/JCAM.5937 Received: 17.06.2018 Accepted: 11.07.2018 Published Online: 17.07.2018 Printed: 01.05.2019 J Clin Anal Med 2019;10(3): 376-8 Corresponding Author: Seher Erdoğan, Umraniye Research and Training Hospital, Adem Yavuz Cad. No:1, 34764, Ümraniye, İstanbul, Türkiye. GSM: +905326678370 E-Mail: seher70@gmail.com ORCID ID: 0000-0002-3393-3363 Abstract Aim: Therapeutic plasma exchange (TPE) is an extracorporeal treatment technique that allows the removal of unwanted substances with large molecule weight from the blood. In this study, it was aimed to retrospectively assess patients who underwent therapeutic plasmapheresis. Material and Method: The medical data of patients who underwent TPE in the 10-bed pediatric intensive care unit of Ümraniye TRH between May 2017 and May 2018 were retrospectively assessed. Age, sex, body weight, plasmapheresis indications, plasmapheresis technique, complication and mortality rates were recorded. Results: TPE was performed in a total of 19 patients. The mean age of the study population was 8.8 ± 5.9 years. Ten (52.6%) patients were provided respiratory support with mechanical ventilator; the mean duration of ventilator support for these patients was 10.3 ± 10 days. The most common indication for TPE was autoimmune encephalitis with a rate of 42% (8/19 patients); the other indications were: collagen tissue disorder activation, hepatic failure, mitochondriopathic encephalopathy, Guillain-Barre syndrome, septic shock, and hemophagocytic syndrome. The patients were administered totally 5.94 ± 1.69 sessions of TPE, min 3-max 8). As a replacement fluid, fresh frozen plasma (FFP) was used in 17 patients and albumin in 2 patients. The most common complication was catheter-related complications. None of the patients died during the procedure. One patient was followed up for Hashimoto encephalitis and another patient who was followed up for septic shock died. Discussion: TPE is a treatment method that is invasive but with low-side effect profile; it is used to stop disease progression in lifethreatening autoimmune disorders unresponsive to a medical treatment.","PeriodicalId":44485,"journal":{"name":"Journal of Clinical and Analytical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41735333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
DOI: 10.4328/JCAM.6132 Received: 18.12.2018 Accepted: 27.12.2018 Published Online: 28.12.2018 Printed: 01.05.2019 J Clin Anal Med 2019;10(3): 307-10 Corresponding Author: Timur Koca, Radyasyon Onkolojisi ABD, Akdeniz Üniversitesi Tıp Fakültesi, Konyaaltı, Antalya, Türkiye. GSM: +905422018722 E-Mail: timurkoca3@gmail.com ORCID ID: 0000-0002-7400-1837 Abstract Aim: The aim of this study was to investigate the antimicrobial effect of essential oils obtained from Mediterranean region plants on microorganisms isolated as secondary skin infections in patients with Grade II and III acute radiation dermatitis. Material and Method: The antimicrobial activity of essential oils, Origanum vulgare (O. vulgare), Lavandula intermedia (L. intermedia) and Thymus vulgaris (T. vulgaris) were evaluated by broth microdilution method on microorganisms isolated from 20 patients with Grade II and III radiation dermatitis. Microdilutions had modified according to The Clinical and Laboratory Standards Institute (CLSI) recommendations and lowest concentration which inhibited growth after incubation was identified as Minimal Inhibitory Concentration (MIC). The severity degree of acute radiation dermatitis was graded according to the Common Terminology Criteria for Adverse Events (CTCAE) version 4.03. Results: Nine pathogenic strains were isolated from 20 samples of the patients. The pathogens isolated from skin swabs of the patients with Grade II and III radiation dermatitis were Methicillin-resistant Staphylococcus aureus (MRSA), methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant coagulasenegative Staphylococcus (MRCNS), methicillin-sensitive coagulase-negative Staphylococcus (MSCNS), Klebsiella pneumoniae (K. pneumoniae) and Candida albicans (C. albicans). Minimal Inhibitory Concentration values of O. vulgare, L. intermedia and T. vulgaris for each isolated microorganisms were found. These essential oils have been found effective on microorganisms isolated from secondary infections of radiation-related dermatitis. Discussion: Antimicrobial activity of O. vulgare, L. intermedia and T. vulgaris essential oils on pathogenic microorganisms isolated from radiation dermatitis were determined. Future use of essential oils in the treatment of acute radiation dermatitis should be considered.
DOI: 10.4328 / JCAM.6132收稿日期:18.12.2018收稿日期:27.12.2018出版日期:28.12.2018印刷日期:01.05.2019 J clinical Anal Med 2019;10(3): 307-10通讯作者:Timur Koca, Radyasyon Onkolojisi ABD, Akdeniz Üniversitesi Tıp fak ltesi, konyaaltyi, Antalya, t rkiye。摘要目的:本研究旨在探讨地中海地区植物精油对II级和III级急性放射性皮炎患者继发皮肤感染分离微生物的抑菌作用。材料与方法:采用微量肉汤稀释法，对20例II级和III级放射性皮炎患者分离的微生物进行抑菌活性评价，探讨了精油、普通牛头草(O. vulgare)、中间薰衣草(L. intermedia)和寻常胸腺(T. vulgaris)的抑菌活性。根据临床和实验室标准协会(CLSI)的建议，微稀释度进行了修改，孵育后抑制生长的最低浓度被确定为最低抑制浓度(MIC)。急性放射性皮炎的严重程度根据不良事件通用术语标准(CTCAE) 4.03版进行分级。结果:从20例患者标本中分离出9株致病菌。从II级和III级放射性皮炎患者皮肤拭子中分离到的病原体为耐甲氧西林金黄色葡萄球菌(MRSA)、甲氧西林敏感金黄色葡萄球菌(MSSA)、耐甲氧西林凝固阴性葡萄球菌(MRCNS)、甲氧西林敏感凝固酶阴性葡萄球菌(MSCNS)、肺炎克雷伯菌(肺炎克雷伯菌)和白色念珠菌(白色念珠菌)。得到了各分离菌对普通乳杆菌、中间乳杆菌和普通乳杆菌的最小抑菌浓度。这些精油已被发现对从辐射相关性皮炎继发感染中分离出来的微生物有效。讨论:测定了普通油、中间油和普通油对放射性皮炎病原菌的抑菌活性。应考虑将来使用精油治疗急性放射性皮炎。
{"title":"Antimicrobial activities of essential oils on microorganisms isolated from radiation dermatitis","authors":"T. Koca","doi":"10.4328/JCAM.6132","DOIUrl":"https://doi.org/10.4328/JCAM.6132","url":null,"abstract":"DOI: 10.4328/JCAM.6132 Received: 18.12.2018 Accepted: 27.12.2018 Published Online: 28.12.2018 Printed: 01.05.2019 J Clin Anal Med 2019;10(3): 307-10 Corresponding Author: Timur Koca, Radyasyon Onkolojisi ABD, Akdeniz Üniversitesi Tıp Fakültesi, Konyaaltı, Antalya, Türkiye. GSM: +905422018722 E-Mail: timurkoca3@gmail.com ORCID ID: 0000-0002-7400-1837 Abstract Aim: The aim of this study was to investigate the antimicrobial effect of essential oils obtained from Mediterranean region plants on microorganisms isolated as secondary skin infections in patients with Grade II and III acute radiation dermatitis. Material and Method: The antimicrobial activity of essential oils, Origanum vulgare (O. vulgare), Lavandula intermedia (L. intermedia) and Thymus vulgaris (T. vulgaris) were evaluated by broth microdilution method on microorganisms isolated from 20 patients with Grade II and III radiation dermatitis. Microdilutions had modified according to The Clinical and Laboratory Standards Institute (CLSI) recommendations and lowest concentration which inhibited growth after incubation was identified as Minimal Inhibitory Concentration (MIC). The severity degree of acute radiation dermatitis was graded according to the Common Terminology Criteria for Adverse Events (CTCAE) version 4.03. Results: Nine pathogenic strains were isolated from 20 samples of the patients. The pathogens isolated from skin swabs of the patients with Grade II and III radiation dermatitis were Methicillin-resistant Staphylococcus aureus (MRSA), methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant coagulasenegative Staphylococcus (MRCNS), methicillin-sensitive coagulase-negative Staphylococcus (MSCNS), Klebsiella pneumoniae (K. pneumoniae) and Candida albicans (C. albicans). Minimal Inhibitory Concentration values of O. vulgare, L. intermedia and T. vulgaris for each isolated microorganisms were found. These essential oils have been found effective on microorganisms isolated from secondary infections of radiation-related dermatitis. Discussion: Antimicrobial activity of O. vulgare, L. intermedia and T. vulgaris essential oils on pathogenic microorganisms isolated from radiation dermatitis were determined. Future use of essential oils in the treatment of acute radiation dermatitis should be considered.","PeriodicalId":44485,"journal":{"name":"Journal of Clinical and Analytical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41346661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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