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Message de la présidente. Un Program national de compétences et formation avancées pour la pratique en milieu rural. 来自总统的消息。农村实践的国家高级技能和培训方案。
IF 1.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-04-01 DOI: 10.4103/1203-7796.372318
Sarah Lesperance
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引用次数: 0
Remplacez-moi... S'il vous plaît. Remplacez-moi ...请帮忙。
IF 1.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-04-01 DOI: 10.4103/1203-7796.372316
Peter Hutten-Czapski
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引用次数: 0
Systematic review of the use of metformin compared to insulin for the management of gestational diabetes: Implications for low-resource settings. 二甲双胍与胰岛素在妊娠糖尿病治疗中的系统评价:对低资源环境的影响。
IF 1.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-04-01 DOI: 10.4103/cjrm.cjrm_40_22
Ribal Kattini, Len Kelly, Ruben Hummelen

Introduction: This systematic review examines the effectiveness of metformin treatment compared to insulin treatment for gestational diabetes within the context of a low-resource environment.

Methods: Electronic data searches of Medline, EMBASE, Scopus and Google scholar databases from 1 January, 2005 to 30 June, 2021 were performed using medical subject headings: 'gestational diabetes or pregnancy diabetes mellitus' AND 'Pregnancy or pregnancy outcomes' AND 'Insulin' AND 'Metformin Hydrochloride Drug Combination/or Metformin/or Hypoglycemic Agents' AND 'Glycemic control or blood glucose'. Randomized controlled trials were included if: participants were pregnant women with gestational diabetes mellitus (GDM); the interventions were metformin and/or insulin. Studies among women with pre-gestational diabetes, non-randomised control trials or studies with a limited description of the methodology were excluded. Outcomes included adverse maternal outcomes: weight gain, C-section, pre-eclampsia and glycaemic control and adverse neonatal outcomes: birth weight, macrosomia, pre-term birth and neonatal hypoglycaemia. The revised Cochrane Risk of Bias Assessment for randomised trials was used for the evaluation of bias.

Results: We screened 164 abstracts and 36 full-text articles. Fourteen studies met the inclusion criteria. The studies provide moderate to high-quality evidence demonstrating the effectiveness of metformin as an alternative therapy to insulin. Risk of bias was low; multiple countries and robust sample sizes improved external validity. All studies were from urban centres with no rural data.

Conclusion: These recent high quality studies comparing metformin to insulin for the treatment of GDM generally found either improved or equivalent pregnancy outcome and good glycaemic control for most patients, although many required insulin supplementation. Its ease of use, safety and efficacy suggest metformin may simplify the management of gestational diabetes, particularly in rural and other low-resource environments.

本系统综述探讨了在低资源环境下二甲双胍治疗与胰岛素治疗对妊娠糖尿病的有效性。方法:对2005年1月1日至2021年6月30日的Medline、EMBASE、Scopus和Google scholar数据库进行电子数据检索,检索的医学主题为:“妊娠糖尿病或妊娠糖尿病”、“妊娠或妊娠结局”、“胰岛素”、“盐酸二甲双胍联合用药/或二甲双胍/或降糖药”和“血糖控制或血糖”。纳入随机对照试验的条件包括:受试者为妊娠期糖尿病(GDM)的孕妇;干预措施是二甲双胍和/或胰岛素。排除了对妊娠前糖尿病妇女的研究、非随机对照试验或对方法描述有限的研究。结果包括产妇不良结局:体重增加、剖腹产、先兆子痫和血糖控制;新生儿不良结局:出生体重、巨大儿、早产和新生儿低血糖。采用修订后的Cochrane随机试验偏倚风险评估来评估偏倚。结果:我们筛选了164篇摘要和36篇全文文章。14项研究符合纳入标准。这些研究提供了中等到高质量的证据,证明二甲双胍作为胰岛素替代疗法的有效性。偏倚风险低;多个国家和强大的样本量提高了外部效度。所有的研究都来自城市中心,没有农村数据。结论:这些近期高质量的研究比较了二甲双胍与胰岛素治疗GDM的效果,发现大多数患者的妊娠结局改善或相当,血糖控制良好,尽管许多患者需要补充胰岛素。二甲双胍的易用性、安全性和有效性表明,它可以简化妊娠糖尿病的管理,特别是在农村和其他资源匮乏的环境中。
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引用次数: 0
Social Support for Birthmothers Before and During the COVID-19 Pandemic COVID-19大流行之前和期间为生母提供的社会支持
IF 1.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-04-01 DOI: 10.33844/cjm.2023.6027
Jiyeon Park, Peter A. Johnson, J. Johnson, A. Mardon
Giving birth is not a simple event and requires much attention, care, and support to result in a positive birth experience. However, the process of giving birth changed significantly during the COVID-19 pandemic due to the spread of the virus, the uncertainty of the virus, and the numerous restrictions implemented. These led to isolation, loneliness, a lack of communication, loss of control over the body, and little or no contribution to decision-making for the new birth mother. This, as well as a lack of social support, can harm a mother’s and baby’s mental and physical health. Thus, this article explores the importance of social support and its role before the COVID-19 pandemic, as well as the changes that have occurred in the birth process during the COVID-19 pandemic.
生孩子不是一件简单的事情,需要很多的关注、照顾和支持,才能有一个积极的分娩经历。然而,在2019冠状病毒病大流行期间,由于病毒的传播、病毒的不确定性以及实施的众多限制措施,分娩过程发生了重大变化。这些导致了孤立、孤独、缺乏沟通、失去对身体的控制,以及对新妈妈的决策贡献很少或根本没有。这一点,加上缺乏社会支持,会损害母亲和婴儿的身心健康。因此,本文探讨了COVID-19大流行前社会支持的重要性及其作用,以及COVID-19大流行期间出生过程中发生的变化。
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引用次数: 0
Simulation-Based Software Modeling of CAR T Cell Therapy Efficacy Against Solid Malignant Tumors 基于仿真的CAR - T细胞治疗实体恶性肿瘤疗效软件建模
IF 1.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-04-01 DOI: 10.33844/cjm.2023.6029
Daivat Bhavsar, Y. Li
Genetically engineered T cells with Chimeric Antigen Receptors, CAR T cells, are a revolutionary immunotherapy used to treat advanced blood cancers. The purpose of this experiment was to model the destruction process of tumor cells with CAR T cell therapy using Complexity and Organized Behaviour Within Environmental Bounds (COBWEB), an agent-based simulation software. We designated parameter values for abiotic factors, agents (i.e. tumor cells, T cells) and the general environment in our immunotherapy simulation model to illustrate the interactions between tumor cells and cytotoxic components, which described the binding of innate CD8+ T cells or CAR T cells to tumor antigens. The models were used to observe and comparatively analyze the rate of destruction of a solid tumor by CAR T cells and innate CD8+ T cells. The solid tumor developed in a circular island for 60 ticks, representing days; innate CD8+ or CAR T cells were then able to infiltrate the island and the tumor cell population was monitored over 500 days. The CAR T cells exhibited a significantly powerful, efficient immune response against a general solid tumor relative to the innate CD8+ T cells, yet relapse occurred in both models albeit to a lesser extent with CAR T cells. However, further investigations are required to adequately simulate the side effects and realistically-limiting factors of CAR T cell therapy. Similar comparative analyses may help measure and compare the potency of the immune response of CAR T cells compared to standard, or lack of, treatments.
带有嵌合抗原受体的基因工程T细胞,即CAR - T细胞,是一种用于治疗晚期血癌的革命性免疫疗法。本实验的目的是利用基于智能体的模拟软件“环境边界内的复杂性和有组织行为”(COBWEB)来模拟CAR - T细胞治疗对肿瘤细胞的破坏过程。在我们的免疫治疗模拟模型中,我们指定了非生物因素、药物(即肿瘤细胞、T细胞)和一般环境的参数值,以说明肿瘤细胞和细胞毒性成分之间的相互作用,这些成分描述了先天CD8+ T细胞或CAR - T细胞与肿瘤抗原的结合。这些模型被用来观察和比较分析CAR - T细胞和先天CD8+ T细胞对实体瘤的破坏率。实体瘤在一个环形岛中发展了60个蜱,代表天;然后,先天CD8+或CAR - T细胞能够浸润到岛上,并在500天内监测肿瘤细胞群。相对于先天CD8+ T细胞,CAR - T细胞对一般实体瘤表现出显著强大、有效的免疫应答,然而在两种模型中都发生复发,尽管CAR - T细胞的复发程度较低。然而,需要进一步的研究来充分模拟CAR - T细胞治疗的副作用和现实限制因素。类似的比较分析可能有助于测量和比较CAR - T细胞与标准治疗或缺乏治疗相比的免疫反应效力。
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引用次数: 0
Increasing Awareness of Low Incidence Disease as Immigration Rates Increase: A Recent Case of Pott’s Disease in Atlantic Canada 随着移民率的增加,对低发病率疾病的认识不断提高:加拿大大西洋地区最近一例波特病
IF 1.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-04-01 DOI: 10.33844/cjm.2023.6026
Z. Stanton, Moira A Law, I. Shamputa, D. Webster, Kimberley Barker
As Canada experiences and prepares for notable increases in immigration, health care professionals need to be aware of emerging cases of low incidence diseases, particularly when found in higher rates in the foreign-born population. Therefore, we report the case of a 20-year-old male immigrant presenting to a Canadian emergency department with a one year history of worsening back pain. In the emergency department, thoracic radiographs showed pathologic fractures at T10 and T11 with destructive changes from T8 to T12. Further, a computed tomography scan identified a large paravertebral abscess from T6 to L1, with osseous destruction and spinal stenosis. Magnetic resonance imaging showed bony deformity, epidural, pre-and paravertebral, and bilateral psoas abscesses, and a right-sided pleural effusion. Diagnosis was confirmed with direct molecular testing and treatment was initiated in a timely and efficacious manner. This case report highlights the need for health care providers to have a high index of suspicion and consideration of atypical presentations of low incidence diseases, particularly within the burgeoning immigrant population, to ensure quality health care services are delivered.
随着加拿大经历并准备迎接移民的显著增加,保健专业人员需要注意新出现的低发病率疾病病例,特别是在外国出生人口中发病率较高的病例。因此,我们报告一个20岁的男性移民到加拿大急诊科,有一年的背痛恶化史。在急诊科,胸片显示T10和T11病理性骨折,T8至T12发生破坏性改变。此外,计算机断层扫描发现从T6到L1有一个大的椎旁脓肿,伴有骨破坏和椎管狭窄。磁共振成像显示骨畸形,硬膜外,椎前和椎旁,双侧腰肌脓肿,右侧胸腔积液。经直接分子检测确诊,及时有效治疗。本病例报告强调卫生保健提供者需要高度怀疑和考虑低发病率疾病的非典型表现,特别是在迅速增长的移民人口中,以确保提供高质量的卫生保健服务。
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引用次数: 0
Staffing rural emergency departments in Ontario: The who, what and where. 安大略省农村急诊科的人员配置:谁,什么和在哪里。
IF 1.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-04-01 DOI: 10.4103/cjrm.cjrm_51_22
Tyler Randle, Arunim Garg, Vijay Mago, Salimur Choudhury, Robert Ohle, Roger Strasser, Sean W Moore, Aimee Kernick, David W Savage

Introduction: The emergency department (ED) in rural communities is essential for providing care to patients with urgent medical issues and those unable to access primary care. Recent physician staffing shortages have put many EDs at risk of temporary closure. Our goal was to describe the demographics and practices of the rural physicians providing emergency medicine services across Ontario in order to inform health human resource planning.

Methods: The ICES Physician database (IPDB) and Ontario Health Insurance Plan (OHIP) billing database from 2017 were used in this retrospective cohort study. Rural physician data were analysed for demographic, practice region and certification information. Sentinel billing codes (i.e., a billing code unique to a particular clinical service) were used to define 18 unique physician services.

Results: A total of 1192 physicians from the IPDB met inclusion as rural generalist physicians out of a total of 14,443 family physicians in Ontario. From this physician population, a total of 620 physicians practised emergency medicine which accounted for 33% of their days worked on average. The majority of physicians practising emergency medicine were between the ages of 30 and 49 and in their first decade of practice. The most common services in addition to emergency medicine were clinic, hospital medicine, palliative care and mental health.

Conclusion: This study provides insight into the practice patterns of rural physicians and the basis for better targeted physician workforce-forecasting models. A new approach to education and training pathways, recruitment and retention initiatives and rural health service delivery models is needed to ensure better health outcomes for our rural population.

简介:农村社区的急诊科(ED)对于为有紧急医疗问题和无法获得初级保健的患者提供护理至关重要。最近医生人手短缺使许多急诊科面临暂时关闭的危险。我们的目标是描述安大略省各地提供急诊医疗服务的农村医生的人口统计和做法,以便为卫生人力资源规划提供信息。方法:采用2017年ICES医师数据库(IPDB)和安大略省健康保险计划(OHIP)计费数据库进行回顾性队列研究。对农村医生资料进行人口统计、执业地区和认证信息分析。哨兵计费代码(即,特定临床服务的唯一计费代码)用于定义18种唯一的医生服务。结果:安大略省共有14443名家庭医生,IPDB共有1192名医生符合农村全科医生的纳入标准。在这些医生当中,共有620名医生从事急诊医学工作,占他们平均工作日数的33%。大多数从事急诊医学的医生年龄在30至49岁之间,并且在他们的第一个十年执业。除急诊医学外,最常见的服务是诊所、医院医学、姑息治疗和心理健康。结论:本研究为深入了解农村医生的执业模式提供了依据,为建立更有针对性的医生劳动力预测模型提供了依据。需要对教育和培训途径、征聘和留用举措以及农村保健服务提供模式采取新的做法,以确保改善农村人口的保健成果。
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引用次数: 0
Replace me... please? 代替我……好吗?
IF 1.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-04-01 DOI: 10.4103/cjrm.cjrm_3_23
Peter Hutten-Czapski
{"title":"Replace me... please?","authors":"Peter Hutten-Czapski","doi":"10.4103/cjrm.cjrm_3_23","DOIUrl":"https://doi.org/10.4103/cjrm.cjrm_3_23","url":null,"abstract":"","PeriodicalId":44615,"journal":{"name":"Canadian Journal of Rural Medicine","volume":"28 2","pages":"43"},"PeriodicalIF":1.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9233408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
President's Message - A national advanced skills and training program for rural practice. 总统致辞-农村实践的国家先进技能和培训计划。
IF 1.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-04-01 DOI: 10.4103/cjrm.cjrm_4_23
Sarah Lesperance
{"title":"President's Message - A national advanced skills and training program for rural practice.","authors":"Sarah Lesperance","doi":"10.4103/cjrm.cjrm_4_23","DOIUrl":"https://doi.org/10.4103/cjrm.cjrm_4_23","url":null,"abstract":"","PeriodicalId":44615,"journal":{"name":"Canadian Journal of Rural Medicine","volume":"28 2","pages":"45"},"PeriodicalIF":1.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9233409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The occasional bone marrow biopsy. 偶尔的骨髓活检。
IF 1.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-04-01 DOI: 10.4103/cjrm.cjrm_64_22
Peter Hutten-Czapski
{"title":"The occasional bone marrow biopsy.","authors":"Peter Hutten-Czapski","doi":"10.4103/cjrm.cjrm_64_22","DOIUrl":"https://doi.org/10.4103/cjrm.cjrm_64_22","url":null,"abstract":"","PeriodicalId":44615,"journal":{"name":"Canadian Journal of Rural Medicine","volume":"28 2","pages":"82-85"},"PeriodicalIF":1.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9239834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Canadian Journal of Rural Medicine
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